Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.3
USERS' SCORE
Good
Based on 8 Reviews
8.5
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
125 mcg (5,000 IU)
625%

Top Medical Research Studies

5
Vitamin D's role in breast disease
We conducted an observational study to examine the levels of vitamin D in female patients with benign and malignant breast diseases. The research aimed to determine if there is a significant difference in vitamin D levels between those with non-cancerous conditions and those diagnosed with breast cancer.

During the study, we analyzed adult female patients admitted to a surgical department. Importantly, we excluded those who had taken vitamin D supplements recently or who had prior vitamin D deficiencies. By measuring serum vitamin D levels through a specific testing method, we were able to gather meaningful data about their relationship to breast health.

Our findings indicated a notable difference in average vitamin D levels when comparing the two groups. This suggests that inadequate vitamin D could be linked to an increased risk of developing breast cancer. Therefore, we explored the potential benefits of vitamin D supplementation as a preventive measure against breast cancer—though we acknowledge that larger and more controlled studies are essential to draw firm conclusions.

At the same time, we recognize that vitamin D has effects beyond bone health, and it is crucial to consider these broader impacts when discussing its role in cancer risk.
Read More
We explored the potential benefits of a vitamin D analog in treating prostate cancer, which is a major cause of cancer-related deaths among men. Our work focused on understanding how this vitamin D form impacts cancer resistance and the tumor microenvironment. We used the Pten mouse model to observe the therapeutic effects of the vitamin D analog.

One significant finding was that combining this vitamin D analog with the chemotherapy drug docetaxel could overcome resistance seen in some prostate cancer cases. This combination showed promising results in primary cancer spheroids and xenografts from a patient whose cancer had resisted both docetaxel and androgen deprivation therapy.

These insights suggest that vitamin D analogs might offer new and effective strategies for managing advanced prostate cancer, particularly for those patients who have not responded well to standard treatments.
Read More
We explored the potential of vitamin D-based micelles designed to deliver paclitaxel, a key chemotherapy drug, specifically for pancreatic cancer treatment. This study focuses on developing enzyme-responsive micelles that not only carry paclitaxel but also utilize vitamin D as an integral part of the delivery system.

The micelles are made by combining vitamin D with polyethylene glycol, resulting in tiny structures that can release their drug load when interacting with enzymes typically found in pancreatic cancer cells. We observed that these micelles showed promising results in laboratory settings, enhancing the effectiveness of paclitaxel against aggressive pancreatic cancer cells compared to using paclitaxel alone.

Moreover, we noted that the vitamin D in the micelles may play a dual role: serving as both a hydrophobic core for drug delivery and a contributor to synergetic therapeutic effects. Our findings suggest that leveraging vitamin D in this way could increase the efficacy of existing treatment options for pancreatic cancer patients, which is particularly significant given the challenges currently faced in treating this disease.
Read More

Most Useful Reviews

9.5
Cancer cell inhibition
Vitamin D supports cell growth, restores immunity, and inhibits the growth of cancer cells, making it essential for overall health.
Read More
8.8
Cell differentiation
Vitamin D aids in cell differentiation, preventing immature cells from becoming cancerous. It's crucial for inducing apoptosis, allowing damaged cells to die, particularly in relation to breast, colon, and prostate cancer.
Read More
9.5
Mortality connection
Vitamin D is vital for bone health, especially in those not living near the equator. Low levels are linked to increased mortality and certain cancers, emphasising the necessity of supplementation.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.3
  • All Researches
We explored the potential of vitamin D-based micelles designed to deliver paclitaxel, a key chemotherapy drug, specifically for pancreatic cancer treatment. This study focuses on developing enzyme-responsive micelles that not only carry paclitaxel but also utilize vitamin D as an integral part of the delivery system.

The micelles are made by combining vitamin D with polyethylene glycol, resulting in tiny structures that can release their drug load when interacting with enzymes typically found in pancreatic cancer cells. We observed that these micelles showed promising results in laboratory settings, enhancing the effectiveness of paclitaxel against aggressive pancreatic cancer cells compared to using paclitaxel alone.

Moreover, we noted that the vitamin D in the micelles may play a dual role: serving as both a hydrophobic core for drug delivery and a contributor to synergetic therapeutic effects. Our findings suggest that leveraging vitamin D in this way could increase the efficacy of existing treatment options for pancreatic cancer patients, which is particularly significant given the challenges currently faced in treating this disease.
Read More
We explored the potential benefits of a vitamin D analog in treating prostate cancer, which is a major cause of cancer-related deaths among men. Our work focused on understanding how this vitamin D form impacts cancer resistance and the tumor microenvironment. We used the Pten mouse model to observe the therapeutic effects of the vitamin D analog.

One significant finding was that combining this vitamin D analog with the chemotherapy drug docetaxel could overcome resistance seen in some prostate cancer cases. This combination showed promising results in primary cancer spheroids and xenografts from a patient whose cancer had resisted both docetaxel and androgen deprivation therapy.

These insights suggest that vitamin D analogs might offer new and effective strategies for managing advanced prostate cancer, particularly for those patients who have not responded well to standard treatments.
Read More
5
Vitamin D's role in breast disease
We conducted an observational study to examine the levels of vitamin D in female patients with benign and malignant breast diseases. The research aimed to determine if there is a significant difference in vitamin D levels between those with non-cancerous conditions and those diagnosed with breast cancer.

During the study, we analyzed adult female patients admitted to a surgical department. Importantly, we excluded those who had taken vitamin D supplements recently or who had prior vitamin D deficiencies. By measuring serum vitamin D levels through a specific testing method, we were able to gather meaningful data about their relationship to breast health.

Our findings indicated a notable difference in average vitamin D levels when comparing the two groups. This suggests that inadequate vitamin D could be linked to an increased risk of developing breast cancer. Therefore, we explored the potential benefits of vitamin D supplementation as a preventive measure against breast cancer—though we acknowledge that larger and more controlled studies are essential to draw firm conclusions.

At the same time, we recognize that vitamin D has effects beyond bone health, and it is crucial to consider these broader impacts when discussing its role in cancer risk.
Read More

User Reviews

USERS' SCORE
Good
Based on 8 Reviews
8.5
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9.5
Cancer cell inhibition
Vitamin D supports cell growth, restores immunity, and inhibits the growth of cancer cells, making it essential for overall health.
Read More
8.8
Cell differentiation
Vitamin D aids in cell differentiation, preventing immature cells from becoming cancerous. It's crucial for inducing apoptosis, allowing damaged cells to die, particularly in relation to breast, colon, and prostate cancer.
Read More
9.5
Mortality connection
Vitamin D is vital for bone health, especially in those not living near the equator. Low levels are linked to increased mortality and certain cancers, emphasising the necessity of supplementation.
Read More
8
Vitamin D3 benefits
People with high levels of vitamin D3 in their blood tend to live longer. The World Health Organisation recommends 400-600 IU, but some suggest 2000 IU for optimal health. Vitamin D3 aids in inhibiting ageing and is more challenging to absorb with age. A deficiency can speed up mental decline. I observed a low level of vitamin D despite taking supplements, indicating I might require a higher dosage.
Read More
8.8
Chronic disease reduction
Vitamin D3 increases levels in the body, strengthens bones, reduces chronic disease risks like diabetes and cancer, boosts immunity, and promotes dental health.
Read More

Frequently Asked Questions

Cancer is a complex group of diseases characterized by uncontrolled growth and spread of abnormal cells in the body. These cells can form tumors, invade nearby tissues, and metastasize to other parts of the body via the bloodstream or lymphatic system. While cancer can affect nearly any part of the body, it is classified into various types, including carcinomas, sarcomas, leukemia, and lymphomas, each originating from different types of cells. Risk factors for developing cancer can include genetic predisposition, lifestyle choices such as smoking and diet, environmental exposures, and certain infections.

Diagnosis typically involves medical imaging, biopsies, and a thorough review of personal and family health histories. Treatment options vary widely depending on the type and stage of cancer and may include surgery, chemotherapy, radiation therapy, immunotherapy, and targeted therapies. Early detection is crucial and can significantly improve treatment outcomes, leading to better survival rates. As awareness and research continue to advance, new methods for prevention, detection, and treatment of cancer are consistently being developed, offering hope to those affected by this challenging disease.

Vitamin D is a fat-soluble vitamin that's essential for maintaining healthy bones and teeth, supporting immune system function, and facilitating normal cell growth and development. It plays a crucial role in calcium absorption in the gut, which is vital for bone health. Unlike most vitamins, our bodies can produce Vitamin D when exposed to sunlight, specifically UVB rays, which is why it’s often referred to as the "sunshine vitamin." However, depending on your geographical location, lifestyle, and skin type, getting sufficient Vitamin D from the sun alone can be challenging, particularly during the winter months.

In addition to sunlight, Vitamin D can be obtained from certain foods such as fatty fish (like salmon and mackerel), fish liver oils, and fortified foods like milk and cereals. Some individuals may also consider supplements, especially if they're at risk for deficiency. Insufficient vitamin D levels are linked to various health issues, including rickets in children, osteomalacia in adults, and even an increased risk of chronic diseases. Regularly checking your vitamin D levels and consulting with a healthcare professional can help ensure you're meeting your needs for optimal health.

While there is ongoing research into the role of vitamin D in cancer prevention and treatment, the findings remain inconclusive. Some studies suggest that adequate levels of vitamin D may be associated with a lower risk of certain cancers, such as colorectal cancer and breast cancer, potentially due to its role in regulating cell growth and differentiation. However, definitive evidence proving that vitamin D supplements can prevent or successfully treat cancer is still lacking.

It’s important to approach the idea of using vitamin D as a cancer treatment with caution. Current guidelines recommend obtaining vitamin D primarily through safe sun exposure and diet. If you’re considering vitamin D supplementation, particularly for cancer-related purposes, it’s crucial to consult with a healthcare provider. They can provide personalized advice based on individual health needs and the latest research, ensuring that any approach to cancer management is both safe and effective.

Based on user reviews, the timeline for seeing results from vitamin D supplementation, particularly in the context of cancer support, appears to vary from person to person. While specific timelines for observable effects on cancer are not explicitly discussed in the reviews, users indicate that regular supplementation contributes to improved overall health and potentially reduces long-term cancer risk. For instance, one user emphasized the importance of maintaining adequate vitamin D levels for immune function, which is critical for combating diseases including cancer (Read Review).

Another review highlighted the role of vitamin D in cell health, suggesting that its effects on cancer cell growth might manifest progressively over time. Specifically, a user mentioned the importance of taking higher doses to achieve sufficient blood levels, suggesting that it might take a while to notice significant benefits if dosage is not optimal (Read Review). Overall, while immediate effects may not be evident, users recommend consistent intake and monitoring to assess individual response to vitamin D.

The research surrounding vitamin D and its potential role in cancer treatment is gaining traction, with several studies highlighting its possible benefits. For instance, in a study investigating a vitamin D analog for prostate cancer, researchers found that it could enhance the effects of chemotherapy, particularly when used alongside docetaxel. This combination showed promising results in overcoming treatment resistance seen in advanced prostate cancer cases, suggesting that vitamin D analogs could provide new avenues for managing this disease [1].

Additionally, observational studies on breast cancer indicate a correlation between low vitamin D levels and an increased risk of developing the disease. These findings propose that vitamin D supplementation may serve as a preventive measure against breast cancer, although further controlled studies are necessary to establish causal relationships [2]. Finally, research into vitamin D-infused micelles for delivering chemotherapy in pancreatic cancer shows that this innovative approach may enhance drug efficacy, addressing significant challenges in treating this aggressive cancer type [3]. Overall, while the findings are promising, more extensive clinical trials are essential to fully understand the effects of vitamin D in cancer treatment.

Users have reported various improvements in their symptoms after using vitamin D supplements, particularly concerning overall health and specific chronic conditions. A number of reviewers emphasized that vitamin D supports immune function, which can enhance your body’s ability to fight off diseases and may potentially lower the long-term risk of certain cancers (Read Review). Many users pointed out benefits related to bone health, with one user noting that adequate vitamin D levels significantly contribute to reducing the risks of chronic diseases like diabetes and various cancer forms (Read Review). They mentioned that adequate supplementation is crucial for maintaining overall health and vitality, especially for those living in areas with limited sunlight (Read Review).

Additionally, the potential for improved vitality and longevity was another commonly cited benefit among users taking vitamin D, with some expressing that higher levels of this vitamin in the blood correlate with extended life expectancy (Read Review). Users noted positive effects on muscle tone and joint health, with one reviewer mentioning improved muscle strength and immunity (Read Review). However, it's important to note that individual responses to supplementation can vary, and optimal dosing should be calibrated according to personal health needs and absorption capabilities (Read Review).

Users have reported favorable outcomes when combining vitamin D with other supplements for cancer management. Reviewers highlighted that vitamin D supports cell differentiation, which is crucial for preventing immature cells from becoming cancerous and promoting apoptosis in damaged cells, particularly relating to breast, colon, and prostate cancers (Read Review). Additionally, vitamin D is associated with stronger immune function and overall health, suggesting that it could potentially reduce long-term cancer risks when taken alongside other supplements aimed at boosting immunity and cellular health (Read Review).

Furthermore, users noted the importance of adequate vitamin D levels for various aspects of health, including bone strength and reducing chronic disease risks, which contributes indirectly to cancer management (Read Review). Some individuals mentioned adjusting their vitamin D dosage when they discovered low levels despite supplementation, suggesting a personalized approach may be necessary for optimal results (Read Review). Ultimately, the combination of vitamin D with other health supplements appears to be a strategic approach favored by many users seeking to address cancer-related concerns effectively.

Based on user reviews, there is a notable consensus on the importance of Vitamin D dosage for cancer treatment. Users report that while the World Health Organisation recommends a daily intake of 400-600 IU, higher doses such as 2000 IU may be more effective for optimal health and cancer prevention (Read Review). Many individuals mention that achieving sufficient levels of Vitamin D is particularly challenging, especially as one ages, which can necessitate higher supplementation doses (Read Review).

Users emphasize the critical role of Vitamin D in reinforcing the immune system, inhibiting the growth of cancer cells, and supporting overall health, with some noting the link between low Vitamin D levels and increased mortality and specific cancers (Read Review). Regular supplementation is recommended, as Vitamin D3 not only supports bone health but also aids in cell differentiation and apoptosis, crucial for preventing cancerous growths (Read Review). Taking Vitamin D supplements is a common practice among users, with some opting for daily capsules to ensure they maintain appropriate levels (Read Review).

8.8
Reduced cancer risk
Jarrow Vitamin D3 boosts immune function, contributing to better health and potentially reducing the long-term risk of certain cancers, including infections.
8
Vitamin D3 benefits
People with high levels of vitamin D3 in their blood tend to live longer. The World Health Organisation recommends 400-600 IU, but some suggest 2000 IU for optimal health. Vitamin D3 aids in inhibiting ageing and is more challenging to absorb with age. A deficiency can speed up mental decline. I observed a low level of vitamin D despite taking supplements, indicating I might require a higher dosage.
8.8
Chronic disease reduction
Vitamin D3 increases levels in the body, strengthens bones, reduces chronic disease risks like diabetes and cancer, boosts immunity, and promotes dental health.
9.5
Mortality connection
Vitamin D is vital for bone health, especially in those not living near the equator. Low levels are linked to increased mortality and certain cancers, emphasising the necessity of supplementation.
8
Thyroid function support
The body needs vitamin D3 year-round, especially in winter. It enhances muscle tone, immunity, thyroid functioning, and prevents cancer cell growth. I take one capsule daily after meals.
8.8
Hormonal synthesis
Vitamin D3 is crucial as its deficiency leads to muscle weakness and joint issues, affecting hormone synthesis and cancer cell growth inhibition. Most individuals struggle to absorb it sufficiently.
8.8
Cell differentiation
Vitamin D aids in cell differentiation, preventing immature cells from becoming cancerous. It's crucial for inducing apoptosis, allowing damaged cells to die, particularly in relation to breast, colon, and prostate cancer.
We explored the potential benefits of a vitamin D analog in treating prostate cancer, which is a major cause of cancer-related deaths among men. Our work focused on understanding how this vitamin D form impacts cancer resistance and the tumor microenvironment. We used the Pten mouse model to observe the therapeutic effects of the vitamin D analog.

One significant finding was that combining this vitamin D analog with the chemotherapy drug docetaxel could overcome resistance seen in some prostate cancer cases. This combination showed promising results in primary cancer spheroids and xenografts from a patient whose cancer had resisted both docetaxel and androgen deprivation therapy.

These insights suggest that vitamin D analogs might offer new and effective strategies for managing advanced prostate cancer, particularly for those patients who have not responded well to standard treatments.
5
Vitamin D's role in breast disease
We conducted an observational study to examine the levels of vitamin D in female patients with benign and malignant breast diseases. The research aimed to determine if there is a significant difference in vitamin D levels between those with non-cancerous conditions and those diagnosed with breast cancer.

During the study, we analyzed adult female patients admitted to a surgical department. Importantly, we excluded those who had taken vitamin D supplements recently or who had prior vitamin D deficiencies. By measuring serum vitamin D levels through a specific testing method, we were able to gather meaningful data about their relationship to breast health.

Our findings indicated a notable difference in average vitamin D levels when comparing the two groups. This suggests that inadequate vitamin D could be linked to an increased risk of developing breast cancer. Therefore, we explored the potential benefits of vitamin D supplementation as a preventive measure against breast cancer—though we acknowledge that larger and more controlled studies are essential to draw firm conclusions.

At the same time, we recognize that vitamin D has effects beyond bone health, and it is crucial to consider these broader impacts when discussing its role in cancer risk.
We explored the potential of vitamin D-based micelles designed to deliver paclitaxel, a key chemotherapy drug, specifically for pancreatic cancer treatment. This study focuses on developing enzyme-responsive micelles that not only carry paclitaxel but also utilize vitamin D as an integral part of the delivery system.

The micelles are made by combining vitamin D with polyethylene glycol, resulting in tiny structures that can release their drug load when interacting with enzymes typically found in pancreatic cancer cells. We observed that these micelles showed promising results in laboratory settings, enhancing the effectiveness of paclitaxel against aggressive pancreatic cancer cells compared to using paclitaxel alone.

Moreover, we noted that the vitamin D in the micelles may play a dual role: serving as both a hydrophobic core for drug delivery and a contributor to synergetic therapeutic effects. Our findings suggest that leveraging vitamin D in this way could increase the efficacy of existing treatment options for pancreatic cancer patients, which is particularly significant given the challenges currently faced in treating this disease.

References

  1. Len-Tayon K, Metzger D, Laverny G. [New insights of vitamin D-based therapy for prostate cancer]. Med Sci (Paris). 2025;41:154. doi:10.1051/medsci/2025011
  2. Soni D, Tiwari A, Kushwah PS, Dubey S, Khan S. Levels of Serum 25-Hydroxy Vitamin D in Benign and Malignant Breast Disease Patients: An Observational Study. Cureus. 2025;17:e78283. doi:10.7759/cureus.78283
  3. Peixoto D, Ravasco JM, Blanco-Fernandez B, Veiga F, Concheiro A, et al. Enzyme-responsive vitamin D-based micelles for paclitaxel-controlled delivery and synergistic pancreatic cancer therapy. Mater Today Bio. 2025;31:101555. doi:10.1016/j.mtbio.2025.101555
image