NOW Supplements D-Mannose

Mannose shows potential against prostate cancer

Possibly Effective

Based on 7 Researches

Deng YL, Liu R, Cai ZD, Han ZD, Feng YF, et al. Mannose inhibits the growth of prostate cancer through a mitochondrial mechanism. Asian J Androl. 2022;24:540. doi:10.4103/aja2021104

We investigated how mannose, a sugar related to glucose, affects prostate cancer cells. Our study found that mannose inhibits cancer cell growth and encourages their programmed death, or apoptosis, in laboratory settings. It also showed promising anticancer effects in mice, all while maintaining their health.

However, the precise mechanisms involved include increased reactive oxygen species and changes in mitochondria, which could pose serious implications. Despite these findings, the benefit of mannose for prostate cancer treatment still needs further exploration, particularly since a related enzyme's lower expression seemed to correlate with worse outcomes for patients.

7.5

Effective for UTI

Most Useful Review

5 people found this helpful

I highly recommend this product for relieving prostate cancer symptoms. I have an enlarged prostate and frequently experience UTIs, making it difficult to urinate. After starting D-Mannose, my symptoms improved significantly, much like antibiotics. I found the powder more effective than the capsules, but the capsules are convenient for travel.

Updated: Mar 2026

Swollen Lymph Nodes details

Perfectly! I’m extremely pleased! I began taking this to lower my leukocytes in my urine analysis. After three months, the urinalysis revealed no signs of inflammatory processes. The imperative urge and swelling of my legs have disappeared.

D-mannose may mitigate IVDD symptoms

Bone Pain details

Dong ZL, Jiao X, Wang ZG, Yuan K, Yang YQ, et al. D-mannose alleviates intervertebral disc degeneration through glutamine metabolism. Mil Med Res. 2024;11:28. doi:10.1186/s40779-024-00529-4

We explored the impact of D-mannose on intervertebral disc degeneration (IVDD), a condition often accompanied by significant pain. The study utilized various sophisticated methods to demonstrate that D-mannose acts primarily through a gene called TXNIP, which influences glutamine metabolism.

Though our findings suggest that D-mannose has promise in alleviating IVDD’s symptoms, we also acknowledge that it has not shown significant pain-relieving effects compared to traditional treatments. Further research may be needed to fully understand its therapeutic potential for pain management.

Relieves bone pain

Most Useful Review

4 people found this helpful

After a problematic gynaecological exam in Norway, I developed issues including bone pain and was diagnosed with cystitis. I tried antibiotics, but they only helped temporarily. However, after taking D-Mannose for three days, I could finally sleep through the night without needing to urinate, and after a week, all my symptoms, including the bone pain, vanished. If I stop taking D-Mannose, the symptoms do return.

Updated: Mar 2026

Cold details

Stable remission achieved

21 people found this helpful

An excellent remedy for cystitis! I have been plagued by this condition since a young age. Despite numerous antibiotics and tests, it always recurred whenever I caught a cold. This dietary supplement, combined with cranberries, has helped me achieve stable remission. I highly recommend it; every girl should have it in her medicine cabinet. Additionally, the capsules are easy to swallow.

Positive treatment effect

Multiple Sclerosis details

My son has multiple sclerosis along with kidney and urinary issues. For six months, he has been on a treatment regimen of two doses per day. Remarkably, the problems have not recurred, and we are very pleased with the results. We intend to continue this treatment consistently.

Updated: Apr 2025

Sleep Apnea details

Effective treatment observed

I found this product very effective for my genitourinary issues. It helped stop my frequent trips to the toilet and improved my night-time sleep.

Abscess details

Effective nanoparticles for abscess treatment

Likely Very Effective

Zhang S, Zhao L, Chen Z, Zhang L, Li L, et al. Macrophage-targeting bioactive glass nanoparticles for the treatment of intracellular infection and subcutaneous abscess. Biomater Sci. 2022;10:6535. doi:10.1039/d2bm01117d

We explored the effectiveness of mannose-modified bioactive glass nanoparticles (BGNs-Man/Ag) in treating subcutaneous abscesses. This innovative treatment targets macrophages to boost their ability to combat intracellular infections.

The results indicated that these nanoparticles not only enhanced the bactericidal activity by increasing M1 macrophage levels but also improved skin tissue regeneration. Overall, BGNs-Man/Ag shows significant promise as a potent treatment option for abscess-related conditions.

Highly effective treatment

Most Useful Review

Cyst Help 5+ is what you need if your problem is E. coli cystitis! It is not an antibiotic, is completely safe for the body, and works exceptionally well against E. coli. I definitely advise you to take it!

Updated: Mar 2026

Autoimmune Disorder details

d-mannose may alleviate psoriasis

Moderately Effective

Based on 5 Researches

Jiang Q, Wei B, You M, Zhou X. d-mannose blocks the interaction between keratinocytes and Th17 cells to alleviate psoriasis by inhibiting HIF-1α/CCL20 in mice. Int Immunopharmacol. 2023;118:110087. doi:10.1016/j.intimp.2023.110087

We explored whether d-mannose can help alleviate psoriasis, an autoimmune condition that causes significant discomfort. Our study demonstrated that both oral and topical applications of d-mannose were effective in reducing psoriasis symptoms in mice.

We discovered that it works by lowering levels of a protein called HIF-1α and the chemokine CCL20 in skin cells. This inhibition interrupts the harmful cycle between keratinocytes and Th17 immune cells. Overall, this suggests d-mannose could be a helpful treatment option for managing psoriasis.

Immediate relief

Most Useful Review

8 people found this helpful

Following laparoscopy, I frequently experienced cystitis due to my autoimmune disorder. After taking d-mannose, I noticed relief almost immediately; the burning sensations and urgency subsided after the initial dose. I'm now taking it regularly and feeling great. Highly recommend!

Updated: Mar 2026

Cardiovascular Disease details

Targeted therapy shows promise

Moderately Effective

Based on 2 Researches

USERS' SCORE

Good

Based on 13 Reviews

Lee SY, Kim JH, Song JW, Min JS, Kim HJ, et al. Macrophage-mannose-receptor-targeted photoactivatable agent for in vivo imaging and treatment of atherosclerosis. Int J Pharm. 2024;654:123951. doi:10.1016/j.ijpharm.2024.123951

We explored a new targeted agent designed to treat atherosclerosis by focusing on macrophage-mannose receptors. This study tested the effectiveness and safety of a specially formulated nanoagent in a mouse model of atherosclerosis.

The agent showed a notable reduction in inflammation within the arterial plaques while being well-tolerated in terms of toxicity. We found it had good imaging capabilities, allowing for better visualization of macrophages linked to atherosclerosis.

Overall, this promising approach may improve both the diagnosis and treatment of cardiovascular diseases linked to atherosclerosis.

Cures cystitis effectively

Most Useful Review

3 people found this helpful

The quality is good; this drug literally cures cystitis after several uses. Minoza, found in cranberries, should be taken for urinary system issues. The dosage is one capsule, which can be taken multiple times daily during the acute stage. The capsules are easy to swallow, and the packaging is sufficient for several courses of administration.

Updated: Mar 2026

Constipation details

Significant improvements

165 people found this helpful

Finally, this has made a difference! I took it to my mother, who has suffered from chronic cystitis for over 20 years, enduring numerous antibiotic injections. Despite that, cystitis remained. It was distressing to watch her struggle, so I convinced her to try something different. I began giving her D-Mannose alongside probiotics, prebiotics, and choleretics to improve her gut health, as E. coli was the root of her problem. We also introduced zinc and vitamin A to strengthen her urinary tract's mucous membrane. After all these years, she has finally shown improvements: she’s not rushing to the toilet as often, the cystitis is less frequent and less painful, and her gastrointestinal health has improved, with reduced flatulence and constipation. It's a natural remedy and has effectively addressed this delicate issue.

Updated: Apr 2025

Yeast Infection details

D-Mannose reduces UTI incidence

Questionable

Based on 3 Researches

Quattrone C, Manfredi C, Napolitano L, Ferraro A, Distefano C, et al. D-Mannose Plus to Prevent Urinary Tract Infections and Discomfort after Cystoscopy: A Single-Center Prospective Randomized Pilot Study. Medicina (Kaunas). 2023;59. doi:10.3390/medicina59061165

We explored how D-mannose could help prevent urinary tract infections and discomfort in patients undergoing cystoscopy. In a well-structured study with 32 patients, those receiving D-mannose experienced significantly fewer UTIs and less severe urinary symptoms compared to those who did not receive treatment.

While the treatment showed promise by reducing the number of infections and pain, no major difference was found in overall quality of life scores between the groups. This indicates D-mannose could be beneficial for specific discomforts related to the procedure.

Effective for prevention

Most Useful Review

31 people found this helpful

I initially experienced burning with D-Mannose, but this subsided as my body adjusted. Having suffered from recurrent UTIs and yeast infections due to antibiotic use, I was desperate for relief. After taking D-Mannose three times daily for seven months, I have had no UTIs, and my mother has seen similar results. Although she had initial discomfort, she also enjoys significant improvement without further antibiotic treatment. I highly recommend D-Mannose for those struggling with traditional remedies.

Updated: Mar 2026

Candidiasis details

This medication perfectly eliminates Candidiasis! I appreciate that it eradicates all fungi without itching, although I’ve noticed an increase in appetite, which is the only downside.

1 people found this helpful

Knee Pain details

It will not prevent exacerbations, but it relieves pain very well. Its dosage is cheaper than medications available in local pharmacies.

Urinary Tract Infection details