NOW Supplements D-Mannose

Supplement Facts

Serving Size: 3 Veg Capsules

Amount Per Serving

%DV

Calories

Total Carbohydrate

1.5 g

<1%**

Total Sugars

1.5 g

†

D-Mannose

1.5 g (1,500 mg)

†

The product is found useful for the following medical conditions

We explored whether d-mannose can help alleviate psoriasis, an autoimmune condition that causes significant discomfort. Our study demonstrated that both oral and topical applications of d-mannose were effective in reducing psoriasis symptoms in mice.

We discovered that it works by lowering levels of a protein called HIF-1α and the chemokine CCL20 in skin cells. This inhibition interrupts the harmful cycle between keratinocytes and Th17 immune cells. Overall, this suggests d-mannose could be a helpful treatment option for managing psoriasis.

8.8

Effective treatment

Most Useful Review

After trying LifeSeasons, Urinari-X, I opted for D-mannose and Cranberries due to persistent cystitis linked to my autoimmune disorder. I found these alternatives to be cost-effective and lasted longer. By taking one of each tablet twice daily throughout winter, I avoided severe attacks. This treatment truly deserves a high rating.

Pelvic Pain details

Thanks to D-mannose, I have started to forget about cystitis. These small capsules work wonders, relieving my pelvic pain and improving my well-being. Cheers to IHerb!

High Cholesterol details

Truly life-changing! A urologist once told me to take antibiotics regularly for chronic urinary tract infections. Upon learning about D-Mannose, I decided to try it. Since I began taking it, I haven’t had a single bladder infection. I highly recommend it to women suffering from chronic urinary tract infections!

Menopause details

SCIENTIFIC SCORE

Moderately Effective

Based on 3 Researches

D-mannose aids menopausal UTI management

Mainini G, Passaro M, Schiattarella A, Franciscis P, Donna MCD, et al. Prevention and treatment of cystitis during menopause: efficacy of a nutraceutical containing D-mannose, inulin, cranberry, bearberry, and . Prz Menopauzalny. 2020;19:130. doi:10.5114/pm.2020.99567

We evaluated the effectiveness of a nutraceutical compound featuring D-mannose, along with cranberry, bearberry, and inulin, in treating recurrent urinary tract infections (UTIs) among menopausal women. In our cohort study, women took this treatment for ten days each month.

At six months, there was a notable decrease in women experiencing recurrent UTIs compared to their baseline. Additionally, at the twelve-month mark, more participants in the treatment group reported being infection-free and showed significant improvement in UTI-related symptoms.

9.5

Pain relief achieved

Most Useful Review

Perfectly! D-Mannose was my solution during this challenging menopause phase. At 49, I struggled with debilitating cystitis. After six months of antibiotics, I sought alternatives and tried D-Mannose, taking 4 capsules five times a day. Improvement was immediate! Now, a life free from pain and antibiotics feels possible! For anyone suffering similarly, D-Mannose and cranberries are miraculous.

Urinary Tract Infection details

SCIENTIFIC SCORE

Questionable

Based on 17 Researches

D-Mannose shows effective UTI treatment

Salvatore S, Ruffolo AF, Stabile G, Casiraghi A, Zito G, et al. A Randomized Controlled Trial Comparing a New D-Mannose-based Dietary Supplement to Placebo for the Treatment of Uncomplicated Escherichia coli Urinary Tract Infections. Eur Urol Focus. 2023;9:654. doi:10.1016/j.euf.2022.12.013

We evaluated a D-mannose-based dietary supplement, the DAPAD complex, to see if it could effectively treat uncomplicated E. coli urinary tract infections (UTIs).

Conducted as a randomized, double-blind trial in India, our study involved 70 nonmenopausal women.

The results were promising: at day six, the DAPAD group showed much higher clinical resolution (34.3% vs. 0%) and effective bacteriological resolution (85.7% vs. 14.3%).

By day 35, symptoms were completely resolved for all in the DAPAD group, while the placebo group still had patients with moderate or severe symptoms.

9.5

Effective for cystitis

Most Useful Review

D-Mannose is the only product that effectively helped my recurrent urinary tract infection caused by E. coli. Clinical trials show its efficacy for genito-urinary infections with no side effects like antibiotics. It doesn't harm beneficial flora, nor does it lead to dysbiosis or fungal infections. It also doesn’t stress the gastrointestinal tract or cause resistance. If you find this review helpful, please click "YES."

Back Pain details

My saviour! Cystitis caused me significant distress during a stressful period. Despite antibiotics, the issue persisted until I discovered D-mannose, which provided relief on the first day of use. I now take it at the first sign of cystitis and have forgotten about sleepless nights. A very good natural remedy that I highly recommend.

Cardiovascular Disease details

SCIENTIFIC SCORE

Moderately Effective

Based on 2 Researches

Targeted therapy shows promise

Lee SY, Kim JH, Song JW, Min JS, Kim HJ, et al. Macrophage-mannose-receptor-targeted photoactivatable agent for in vivo imaging and treatment of atherosclerosis. Int J Pharm. 2024;654:123951. doi:10.1016/j.ijpharm.2024.123951

We explored a new targeted agent designed to treat atherosclerosis by focusing on macrophage-mannose receptors. This study tested the effectiveness and safety of a specially formulated nanoagent in a mouse model of atherosclerosis.

The agent showed a notable reduction in inflammation within the arterial plaques while being well-tolerated in terms of toxicity. We found it had good imaging capabilities, allowing for better visualization of macrophages linked to atherosclerosis.

Overall, this promising approach may improve both the diagnosis and treatment of cardiovascular diseases linked to atherosclerosis.

9.5

Reduced exacerbations

Most Useful Review

WON CHRONIC CYSTITIS! I had cystitis since university, and it took a toll on my life. I regret not starting antibiotics sooner. Eventually, a gynecologist prescribed Nolicin, but after some time, E. coli returned. I tried every antibiotic available without long-term relief. Finally, I was tested for hormones and discovered low progesterone levels. Treatment with hormones was effective, leading to fewer exacerbations. I started using D-mannose from NOW Foods about nine months ago, and I haven't had a single exacerbation since! For me, this product is a miracle!

Kidney Stones details

I have suffered from cystitis for 2.5 years and recently developed kidney stones. After trying various natural remedies, I started taking D-mannose. Initially, I saw no improvement, but after increasing the dosage, I noticed significant relief from urinary discomfort. I now take three tablets every four hours, followed by plenty of water. I'm already on my second month of use and highly recommend it for anyone struggling with kidney stones.

Leg Cramps details

Perfectly! For me, D-Mannose was the only way out! At 49 years old, menopause brought unbearable leg cramps linked to cystitis that worsened before and after menstruation. After suffering for 6 months with constant antibiotics, I found improvement with D-Mannose—4 capsules five times a day for 5 days. It was miraculous; pain and the need for antibiotics disappeared! If you suffer from similar issues, I wholeheartedly recommend D-Mannose and cranberries!

Abscess details

Highly effective treatment

Most Useful Review

Cyst Help 5+ is what you need if your problem is E. coli cystitis! It is not an antibiotic, is completely safe for the body, and works exceptionally well against E. coli. I definitely advise you to take it!

Allergies details

Effective herbal combination

Most Useful Review

I have ordered this product multiple times; it’s a fantastic find for chronic cystitis sufferers. I take it alongside bearberry capsules, and the results have been pleasing. I now believe cranberries are a cure-all for urological issues. There are no side effects, and I experience no allergies. I recommend it wholeheartedly—far better than antibiotics and herbal gels with off-putting tastes and odours.

Candidiasis details

Excellent product! I used to experience monthly UTIs, which required antibiotics and resulted in thrush, leading to bladder irritation. Since I started using d-mannose, I have been without a UTI or thrush for the past five months.

Flu details

Daily preventative tool

Most Useful Review

D-Mannose, where have you been all my life!. I tried these for a mild UTI and was pleasantly surprised by the results. I now take them regularly, preferring the powder form for its efficiency over antibiotics. Capsules are handy for out and about, but I've found the dosage tricky. The guidance on powder versus capsules can be confusing. Nonetheless, these ensure I stay totally free of UTIs. I will never be without this product!

Food Poisoning details

Effective prevention drug

Most Useful Review

The best drug for cystitis! D-mannose is a magic remedy for treating infections caused by E. coli. It works more gently than antibiotics, without harming the liver or increasing bacterial immunity but simply flushes them out. For acute cystitis, it may not alleviate pain immediately if taken in small doses. To learn more, check out Jonathan Wright’s article on D-mannose as an alternative to antibiotics. It’s particularly effective for “newlywed cystitis” if taken pre- and post-intercourse. The recommended dose may seem costly, thus purchasing the powdered version could be more economical.

Thrush details

Excellent product! I suffered from monthly UTIs, relying on antibiotics, which always led to thrush. My bladder felt really irritated. However, since using d-mannose, I haven’t experienced a UTI or thrush in five months.

Adenoiditis details

Alleviates discomfort

Most Useful Review

I purchased these lozenges for myself and find them quite effective. Previously, I took zinc in the picolinate form, but switching to these lozenges has been a great decision (even though the zinc is in a different format here)! They have a pleasant taste and soothe my throat when dissolved. Unlike some pharmaceutical preparations, which can make me nauseous, these lozenges have not caused any issues. If nausea is a problem, I recommend not taking them on an empty stomach. I’ve noticed a significant effect, taking them every 2 hours when I experience a sore throat, and they greatly alleviate discomfort. I highly recommend them!

Benign Tumor details

Highly effective treatment

Most Useful Review

D-Mannose 500 mg proved effective. Last November, I faced severe benign prostatic hyperplasia and cystitis due to stress. After receiving a temporary relief from antibiotics, I sought alternatives. I tried D-Mannose along with cranberry tablets, and by January 7, 2024, over 95% of patients seemed cured. I no longer wake at night, and though I stopped drinking alcohol for stress relief, I find the capsules a bit large, needing to take 9 daily (3 at a time). It’s a bit burdensome, but I manage without issue. Currently, I’m onto my second bottle after purchasing three, contemplating stopping after this last one. While I still have prostate issues, the product is genuinely effective, especially during severe cystitis; results may vary based on individual circumstances.

Cancer details

Reduced UTIs significantly

Most Useful Review

After severe surgical treatment for cancer, I was plagued by UTIs requiring antibiotics monthly for over three years, leaving my gut flora depleted. I tried numerous remedies until discovering D-Mannose. My surgeon approves, stating there's little more he can offer. I've almost completely eliminated UTIs, and taking two 500mg capsules at night has reduced them by at least 95%. This product has been a true blessing for me.

Cold details

Strong combo improvement

Most Useful Review

My go-to for keeping UTIs at bay in colder months! I pair it with cranberry extract for a potent combination. I notice a considerable difference with D-mannose. The capsules are larger but easy to swallow, and the dosage is just right. I'm genuinely happy with this product!

Diabetes details

Now Foods D-Mannose capsules are a fantastic find! I was paying over $32 a bottle locally, so it's a relief to find them at such a low price on iHerb. This product is effective and helps prevent urinary tract infections, which I've experienced frequently since being diagnosed with diabetes in 2006. My order was processed swiftly and shipped the same day, making me a huge fan of iHerb!

Irritable Bowel Syndrome details

This supplement has been a godsend for my mother and me. For years, we struggled with cystitis, relying on antibiotics that provided only temporary relief and came with side effects. Now, this product has allowed us to forgo medication altogether, and I sleep through the night without interruptions. After five years, I have nearly forgotten about cystitis. I take it during spring and autumn for preventive measures, and it has transformed my experience with this condition. It’s truly the best remedy for cystitis I could have hoped for.

Swollen Lymph Nodes details

Perfectly! I’m extremely pleased! I began taking this to lower my leukocytes in my urine analysis. After three months, the urinalysis revealed no signs of inflammatory processes. The imperative urge and swelling of my legs have disappeared.

Yeast Infection details

SCIENTIFIC SCORE

Questionable

Based on 3 Researches

D-Mannose reduces UTI incidence

Quattrone C, Manfredi C, Napolitano L, Ferraro A, Distefano C, et al. D-Mannose Plus to Prevent Urinary Tract Infections and Discomfort after Cystoscopy: A Single-Center Prospective Randomized Pilot Study. Medicina (Kaunas). 2023;59. doi:10.3390/medicina59061165

We explored how D-mannose could help prevent urinary tract infections and discomfort in patients undergoing cystoscopy. In a well-structured study with 32 patients, those receiving D-mannose experienced significantly fewer UTIs and less severe urinary symptoms compared to those who did not receive treatment.

While the treatment showed promise by reducing the number of infections and pain, no major difference was found in overall quality of life scores between the groups. This indicates D-mannose could be beneficial for specific discomforts related to the procedure.

9.5

Life-changing results

Most Useful Review

After suffering from recurrent yeast infections for 3.5 years, I finally found relief. Despite normal test results and various treatments, including antibiotics and traditional remedies, nothing worked until I tried this medication. It has truly given me my life back. I highly recommend it for anyone with chronic yeast infections!

Athlete’s Foot details

Super! I ordered this on the advice of a nutritionist while suffering from frequent cystitis. I hardly felt any discomfort, as I could tell when cystitis was beginning. After taking six capsules at once in the afternoon, I woke up the next morning feeling great. Now, if my feet feel cold, I take three capsules just to be safe.

Celiac details

Supports urinary health

Most Useful Review

The D-Mannose, 500 mg supplement is of excellent quality and a valuable part of my wellness routine. It’s made from premium ingredients, and I appreciate that it's non-GMO and free from common allergens, including gluten, soy, and dairy. The most significant benefit of this supplement is its support for urinary tract health. I've struggled with recurring UTIs previously, and since including this supplement in my routine, I've noticed a considerable reduction in both symptoms and occurrences.

Cold Sores details

Cystitis troubled me this year. I tried various remedies, including antibiotics and cranberries, but struggled until I found this supplement on iHerb. Skeptical at first, I began with three capsules twice daily. After three days, symptoms improved drastically! I’m elated to finally be free from the constant discomfort of cold sores.

Nausea details

Unlike antibiotics, mannose is a natural product. It does not promote the growth of fungal infections by harming the body’s microflora and does not induce nausea, diarrhoea, or dizziness. Mannose carries no addiction risk, making it a great aid for those who have suffered from cystitis. I know its unpleasantness firsthand and highly recommend it!

Anxiety details

Helped with anxiety pee

Most Useful Review

I took this for about two weeks but experienced nausea. However, it immensely helped with my frequent urination issues and offers relief from my anxiety pee. For the first time in five years, I have some normalcy regarding my bladder.

Bacterial Infection details

Improved UTI symptoms

Most Useful Review

It worked; I can't think of a better headline! I previously had no issues with UTIs until 18 months ago. After multiple ineffective antibiotic treatments, I tried D-Mannose when I felt pain again following a previous incident. I took about twelve pills in quick succession, which alleviated the pain within hours, leading to no further UTI symptoms. This method has been effective for me, particularly against E. coli-induced infections.

Headache details

This product is a lifesaver! When I had a bladder infection, it started with a headache that wouldn’t diminish. I always keep this on hand, but when I experienced worsening headaches, I realised I needed it urgently. I took some immediately, and the next morning ordered more for overnight delivery. This remedy saved my life! I highly recommend both the product and the company—I won't run out again!

Heart Disease details

Wonderful! I bought this for a friend’s father who has urination issues. The capsule size is convenient, and the quality is excellent. My friend's dad reports improvements in his condition—no more urination problems.

Constipation details

Significant improvements

Most Useful Review

Finally, this has made a difference! I took it to my mother, who has suffered from chronic cystitis for over 20 years, enduring numerous antibiotic injections. Despite that, cystitis remained. It was distressing to watch her struggle, so I convinced her to try something different. I began giving her D-Mannose alongside probiotics, prebiotics, and choleretics to improve her gut health, as E. coli was the root of her problem. We also introduced zinc and vitamin A to strengthen her urinary tract's mucous membrane. After all these years, she has finally shown improvements: she’s not rushing to the toilet as often, the cystitis is less frequent and less painful, and her gastrointestinal health has improved, with reduced flatulence and constipation. It's a natural remedy and has effectively addressed this delicate issue.

Dizziness details

For several years, I struggled with cystitis, often hospitalized and repeatedly treated with antibiotics that shocked my stomach, leading to erosive gastritis. Taking control of my health, I completed a course of D-mannose in spring, consuming the entire jar, and as autumn arrived, the cystitis symptoms vanished, with clean urine cultures. My health has improved vastly. I now take a prophylactic dose of one tablet at night, alternating months. I highly recommend trying it over heavy antibiotic use. I also suggest a prebiotic with cranberries for women, available on iHerb. Wishing everyone good health!

Heart Attack details

I trust this brand for its top-notch quality. I took three capsules a day for cystitis, which brought quick relief from attacks without harming my body. It was effective for my chronic condition and is also used in Covid treatment, according to my doctor's advice. I recommend it for preventive measures during colds too.

Sleep Apnea details

Improved sleep quality

Most Useful Review

Having IC has significantly improved my life; I no longer wake up excessively at night and my overall wellbeing has markedly improved. My symptoms no longer control me. I'm grateful I discovered I Herb and this product – it's been a life changer. The quality is fantastic; the size is a bit large but manageable. The dosage is easy, and the benefits have been remarkable. I hardly notice any taste. If you suffer from IC, definitely give this a go.

Multiple Sclerosis details

Positive treatment effect

Most Useful Review

My son has multiple sclerosis along with kidney and urinary issues. For six months, he has been on a treatment regimen of two doses per day. Remarkably, the problems have not recurred, and we are very pleased with the results. We intend to continue this treatment consistently.

Prostate Cancer details

SCIENTIFIC SCORE

Possibly Effective

Based on 7 Researches

Mannose shows potential against prostate cancer

Deng YL, Liu R, Cai ZD, Han ZD, Feng YF, et al. Mannose inhibits the growth of prostate cancer through a mitochondrial mechanism. Asian J Androl. 2022;24:540. doi:10.4103/aja2021104

We investigated how mannose, a sugar related to glucose, affects prostate cancer cells. Our study found that mannose inhibits cancer cell growth and encourages their programmed death, or apoptosis, in laboratory settings. It also showed promising anticancer effects in mice, all while maintaining their health.

However, the precise mechanisms involved include increased reactive oxygen species and changes in mitochondria, which could pose serious implications. Despite these findings, the benefit of mannose for prostate cancer treatment still needs further exploration, particularly since a related enzyme's lower expression seemed to correlate with worse outcomes for patients.

9.5

Nearly eliminated UTIs

Most Useful Review

This product has been a lifesaver after facing severe complications from prostate cancer surgery, leading to recurring UTIs. Despite trying various remedies, D-Mannose has almost eradicated my UTIs, and my surgeon fully supports its use. I take two 500mg capsules nightly and have reduced UTI occurrences by about 95%.

Knee Pain details

Pain relief experienced

Most Useful Review

Helped to relieve pain! Initially, I was sceptical about the miraculous claims, but it truly works! At the first signs of cystitis with pain when urinating, I took 3 capsules, then followed the instructions. I consume three capsules three times a day with plenty of water. The pain disappeared on the first day. By the third day, I felt completely normal again. The only downside is the large size of the capsules, which tend to stick in my throat.

Common Cold details

During the entire cold season, I have not experienced any cystitis. I am grateful for this medication.

Bone Pain details

D-mannose may mitigate IVDD symptoms

Dong ZL, Jiao X, Wang ZG, Yuan K, Yang YQ, et al. D-mannose alleviates intervertebral disc degeneration through glutamine metabolism. Mil Med Res. 2024;11:28. doi:10.1186/s40779-024-00529-4

We explored the impact of D-mannose on intervertebral disc degeneration (IVDD), a condition often accompanied by significant pain. The study utilized various sophisticated methods to demonstrate that D-mannose acts primarily through a gene called TXNIP, which influences glutamine metabolism.

Though our findings suggest that D-mannose has promise in alleviating IVDD’s symptoms, we also acknowledge that it has not shown significant pain-relieving effects compared to traditional treatments. Further research may be needed to fully understand its therapeutic potential for pain management.

9.5

Relieves bone pain

Most Useful Review

After a problematic gynaecological exam in Norway, I developed issues including bone pain and was diagnosed with cystitis. I tried antibiotics, but they only helped temporarily. However, after taking D-Mannose for three days, I could finally sleep through the night without needing to urinate, and after a week, all my symptoms, including the bone pain, vanished. If I stop taking D-Mannose, the symptoms do return.