' 
Supplement Facts
Serving Size: About 1/4 cup (31 g)
Amount Per Serving
%DV
Calories
180
Total Fat
13 g
17%
Saturated Fat
3 g
15%
Trans Fat
0 g
Cholesterol
0 mg
0%
Sodium
0 mg
0%
Total Carbohydrate
4 g
1%
Dietary Fiber
2 g
7%
Total Sugars
0 g
Includes 0g Added Sugars
0%
Protein
11g
Vit. D
0 mcg
0%
Calcium
8 mg
0%
Iron
4 mg
20%
Potassium
243 mg
6%
The product is found useful for the following medical conditions
Constipation details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8
USERS' SCORE
Good
Based on 5 Reviews
8.8
7
Diabetes management beverage study
Development of a sodium hyaluronate-enriched therapeutic formulation with stevia glycoside and mogroside V for the comprehensive management of diabetes and its complications.
Most Relevant Research
Our exploration into the management of diabetes and its complications led us to develop a unique beverage formulation. This drink combines stevia glycoside, mogroside V, and sodium hyaluronate, known as SMH-B, which offers a sweet taste without affecting blood sugar levels.
In our study, we found SMH-B to be more than just enjoyable; it plays a key role in addressing various health issues related to diabetes. These include improving skin moisture and elasticity, alleviating constipation, and even reducing signs of depression.
Importantly, we observed that SMH-B helped lower blood glucose and lipid levels as well, proving to be a multifaceted approach to diabetes management. Such findings indicate that integrating protein in our beverage formulation could possibly enhance digestive health and symptomatic relief for those struggling with constipation.
In our study, we found SMH-B to be more than just enjoyable; it plays a key role in addressing various health issues related to diabetes. These include improving skin moisture and elasticity, alleviating constipation, and even reducing signs of depression.
Importantly, we observed that SMH-B helped lower blood glucose and lipid levels as well, proving to be a multifaceted approach to diabetes management. Such findings indicate that integrating protein in our beverage formulation could possibly enhance digestive health and symptomatic relief for those struggling with constipation.
9.5
Highly beneficial
Most Useful Review
I first ordered pumpkin seeds and found them excellent in quality. They’re not large but very clean, and the package was impressive in volume. My family enjoys eating them, and I give them a bit each day as they're beneficial for health. They are said to aid in fighting constipation and boosting immunity. Plus, they contain valuable nutrients like zinc and magnesium. The benefits of pumpkin seeds are immense, and I will certainly purchase them again.
Cardiovascular Disease details
SCIENTIFIC SCORE
Likely Very Effective
Based on 2 Researches
9
USERS' SCORE
Good
Based on 4 Reviews
8.7
9
Maresin 1 improves heart recovery
Maresin 1 Attenuates Myocardium Ischemia/Reperfusion Injury via SIRT1/HMGB-1/NLRP-3-Related Mechanisms.
Most Relevant Research
We investigated how Maresin 1, a protein known for its anti-inflammatory and antioxidant properties, impacts heart injury caused by ischemia/reperfusion (IRI). This condition often arises when blood supply returns to the heart after being restricted, leading to damage.
Using a mouse model for cardiac IRI and an in vitro approach with neonatal rat ventricle myocytes, we aimed to uncover the effects of Maresin 1 on pyroptosis, a type of cell death associated with inflammation. Our findings showed that Maresin 1 significantly reduced the size of heart tissue damage in mice while also lowering the levels of harmful cell death and inflammation.
Moreover, we observed that Maresin 1 works through a specific biological pathway involving SIRT1 and other proteins, helping to curb inflammatory responses during heart attacks. In isolated heart cells, it improved cell health and decreased the damage typically seen with ischemia. These results highlight Maresin 1 as a potential therapeutic option for improving heart recovery after ischemic events.
Using a mouse model for cardiac IRI and an in vitro approach with neonatal rat ventricle myocytes, we aimed to uncover the effects of Maresin 1 on pyroptosis, a type of cell death associated with inflammation. Our findings showed that Maresin 1 significantly reduced the size of heart tissue damage in mice while also lowering the levels of harmful cell death and inflammation.
Moreover, we observed that Maresin 1 works through a specific biological pathway involving SIRT1 and other proteins, helping to curb inflammatory responses during heart attacks. In isolated heart cells, it improved cell health and decreased the damage typically seen with ischemia. These results highlight Maresin 1 as a potential therapeutic option for improving heart recovery after ischemic events.
9.5
Strengthens immunity
Most Useful Review
I ordered pumpkin seeds for the first time. They are excellent quality, not too large, but clean and perfect. The whole family enjoys them, and I provide them daily due to their valuable composition. Pumpkin seeds contain essential nutrients that can help fight cancer and boost immunity, making them beneficial for treating cardiovascular disease. Regular consumption aids the gastrointestinal system, lowers blood pressure, and strengthens blood vessels. The numerous benefits are significant, and I will certainly reorder them. Wishing everyone good health!
Heart Disease details
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.6
USERS' SCORE
Good
Based on 10 Reviews
8.7
9
Maresin 1 improves heart injury outcomes
Maresin 1 Attenuates Myocardium Ischemia/Reperfusion Injury via SIRT1/HMGB-1/NLRP-3-Related Mechanisms.
Most Relevant Research
We examined the potential of Maresin 1 (MaR 1), a compound known for its powerful anti-inflammatory and antioxidant properties, to combat heart ischemia/reperfusion injury (IRI). Conducting experiments on both mice and neonatal rat ventricle myocytes, we assessed how MaR 1 influences the cell death process known as pyroptosis, which is linked to IRI.
Our study revealed that administering MaR 1 before inducing IRI significantly reduced heart damage by lowering the size of heart infarcts, curbing cell death, and decreasing inflammation. The treatment led to notable improvements in heart function by acting on a signaling pathway that includes proteins like SIRT1 and HMGB-1.
In laboratory experiments, MaR 1 not only enhanced cell survival but also lessened harmful enzyme activities associated with heart damage. Moreover, when we used a SIRT1 inhibitor, it became clear that the protective effects of MaR 1 were closely tied to this pathway. This suggests that MaR 1 could offer a promising new avenue for treating cardiac IRI by targeting and reducing inflammation and cell death.
Our study revealed that administering MaR 1 before inducing IRI significantly reduced heart damage by lowering the size of heart infarcts, curbing cell death, and decreasing inflammation. The treatment led to notable improvements in heart function by acting on a signaling pathway that includes proteins like SIRT1 and HMGB-1.
In laboratory experiments, MaR 1 not only enhanced cell survival but also lessened harmful enzyme activities associated with heart damage. Moreover, when we used a SIRT1 inhibitor, it became clear that the protective effects of MaR 1 were closely tied to this pathway. This suggests that MaR 1 could offer a promising new avenue for treating cardiac IRI by targeting and reducing inflammation and cell death.
9
Bone and skin health
Most Useful Review
Pumpkin seeds are fantastic! They enhance bone health and assist with heart disease due to their healthy fats and magnesium. I soak them overnight for better consumption.
Anemia details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 7 Reviews
8.6
8
Romiplostim shows promise in AA
[Efficacy and safety of romiplostim in aplastic anemia refractory or intolerant to immunosuppressive therapy with eltrombopag].
Most Relevant Research
In our exploration of how protein treatments can improve anemia, we focused on the impact of romiplostim, a thrombopoietin receptor agonist, on patients suffering from aplastic anemia (AA) who were either refractory to or intolerant of eltrombopag (EPAG). We studied a group of 18 patients, most of whom had severe AA, who transitioned from EPAG to romiplostim for at least three months.
Remarkably, 72% of these patients responded positively to romiplostim, with many showing improvement in their blood cell counts within the first three months. Of these, half demonstrated a trilineage response, meaning their blood counts improved across multiple cell types. However, we noticed that those who initiated romiplostim a significant time after their initial AA diagnosis tended to struggle to respond effectively.
In instances where treatment with romiplostim was interrupted, we observed that some patients relapsed into thrombocytopenia, suggesting that romiplostim plays a critical role in maintaining blood counts. Overall, our findings indicate that romiplostim can be a valuable option for patients who do not benefit from other treatments, bringing renewed hope in the management of this challenging condition.
Remarkably, 72% of these patients responded positively to romiplostim, with many showing improvement in their blood cell counts within the first three months. Of these, half demonstrated a trilineage response, meaning their blood counts improved across multiple cell types. However, we noticed that those who initiated romiplostim a significant time after their initial AA diagnosis tended to struggle to respond effectively.
In instances where treatment with romiplostim was interrupted, we observed that some patients relapsed into thrombocytopenia, suggesting that romiplostim plays a critical role in maintaining blood counts. Overall, our findings indicate that romiplostim can be a valuable option for patients who do not benefit from other treatments, bringing renewed hope in the management of this challenging condition.
9.5
Helps iron deficiency
Most Useful Review
Amazing! It’s excellent for those who suffer from anaemia and iron deficiency. I always order it.
Arthritis details
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.4
USERS' SCORE
Good
Based on 3 Reviews
8.6
9
Quercetin reduces arthritis inflammation
Quercetin, a Compound of the Total Flavonoids of Schltr., Ameliorates Rheumatoid Arthritis by Targeting TNF-α.
Most Relevant Research
In our exploration of how certain natural compounds can impact rheumatoid arthritis (RA), we focused on the total flavonoids derived from Schltr., specifically identifying the effects of quercetin. Our research employed various methods, including cellular and animal models, to examine how these compounds inhibit TNF-α, a key player in inflammation and joint deterioration.
We discovered that quercetin stands out among several compounds, demonstrating a strong ability to reduce TNF-α activity. This reduction corresponds with decreased cellular injury and apoptosis in our models, showcasing quercetin's potential as a protective agent against RA symptoms. Through advanced techniques such as molecular docking and thermal profiling, we verified that quercetin binds to TNF-α, eventually diminishing the inflammatory processes related to arthritis.
The findings suggest that quercetin plays a significant role in suppressing the TNF-α/NF-κB signaling pathway, which is crucial in the development of RA. By blocking certain inflammatory responses, quercetin appears to mitigate pain and joint damage, positioning it as a hopeful candidate for RA treatment. Overall, our investigation highlights quercetin's promising properties as a natural anti-inflammatory agent for those suffering from arthritis.
We discovered that quercetin stands out among several compounds, demonstrating a strong ability to reduce TNF-α activity. This reduction corresponds with decreased cellular injury and apoptosis in our models, showcasing quercetin's potential as a protective agent against RA symptoms. Through advanced techniques such as molecular docking and thermal profiling, we verified that quercetin binds to TNF-α, eventually diminishing the inflammatory processes related to arthritis.
The findings suggest that quercetin plays a significant role in suppressing the TNF-α/NF-κB signaling pathway, which is crucial in the development of RA. By blocking certain inflammatory responses, quercetin appears to mitigate pain and joint damage, positioning it as a hopeful candidate for RA treatment. Overall, our investigation highlights quercetin's promising properties as a natural anti-inflammatory agent for those suffering from arthritis.
9.5
Beneficial for arthritis
Most Useful Review
The quality is excellent. I have repurchased pumpkin seeds numerous times due to their anti-inflammatory effects, which benefit my periodontal disease and arthritis. They are natural and healthy, making them a long-time staple in my diet.
Common Cold details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 1 Review
8.6
9
GCL1815 shows cold prevention promise
Induces Two Types of Dendritic Cell Activation and Effectively Suppresses Onset of the Common Cold: A Randomized, Double-Blind, Placebo-Controlled Trial.
Most Relevant Research
We aimed to understand if GCL1815, a specific lactic acid bacterium, could play a role in preventing common colds. In a well-structured study, two hundred participants were split into two groups—one taking GCL1815 capsules and the other a placebo—for eight weeks. It was a double-blind setup, meaning neither the participants nor the researchers knew who was receiving the treatment, helping to eliminate bias.
Our findings were quite promising. Those taking GCL1815 reported a lower incidence of common cold symptoms like feverishness and runny nose compared to the placebo group. Specifically, significant changes were observed in two types of dendritic cells in the GCL1815 group, which are crucial for our immune response. This suggests that GCL1815 not only activates these cells but might also enhance our body’s ability to fight off viruses that cause colds.
Overall, this insight points to the potential of GCL1815 in bolstering immune defenses against common colds, offering a potential preventive measure for those concerned about seasonal sniffles. While more research could clarify the exact mechanisms at play, these results hint at an exciting avenue for common cold prevention through dietary means.
Our findings were quite promising. Those taking GCL1815 reported a lower incidence of common cold symptoms like feverishness and runny nose compared to the placebo group. Specifically, significant changes were observed in two types of dendritic cells in the GCL1815 group, which are crucial for our immune response. This suggests that GCL1815 not only activates these cells but might also enhance our body’s ability to fight off viruses that cause colds.
Overall, this insight points to the potential of GCL1815 in bolstering immune defenses against common colds, offering a potential preventive measure for those concerned about seasonal sniffles. While more research could clarify the exact mechanisms at play, these results hint at an exciting avenue for common cold prevention through dietary means.
9.5
Improved immunity
Most Useful Review
I take this high-quality collagen each morning, one capsule during the common cold season. Additionally, in the evening, I take enzymes and bile salts, which assist in removing toxins from my gastrointestinal tract and aid in absorbing fat-soluble vitamins. I also take niacin to ease bile duct spasms and chromium to curb carbohydrate cravings. Before bed, I consume serrapeptase to eliminate mucus and a probiotic to normalise digestion. I'm pleased with the results; my immunity has improved, I feel energised, and my skin, eyes, and hair have all appeared radiant!
Hypothyroidism details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 1 Review
8.6
7
Neudesin levels in hypothyroidism treatment
Serum Neudesin Levels in Patients with Congenital Hypothyroidism.
Most Relevant Research
We explored the relationship between neudesin, a protein linked to brain health and energy regulation, and congenital hypothyroidism (CH). In a study involving 52 patients—32 with CH and 20 healthy controls—we examined the neudesin levels before and after treatment with l-thyroxine, a common medication for hypothyroidism.
Initially, we found that the neudesin levels in patients with CH were not significantly different from those in the control group, with averages of 6.77 ng/mL compared to 7.93 ng/mL. However, after one month of l-thyroxine treatment, neudesin levels showed a notable increase in the CH group, reaching an average of 12.85 ng/mL. This change was statistically significant, providing some insight into how protein levels can respond to thyroid hormone treatment.
While neudesin levels rose with therapy, more research is needed to fully understand the role of this protein in brain development and its implications for patients with congenital hypothyroidism. Our findings suggest that while neudesin itself may not differ at baseline, it could play a part in the recovery process, warranting further exploration.
Initially, we found that the neudesin levels in patients with CH were not significantly different from those in the control group, with averages of 6.77 ng/mL compared to 7.93 ng/mL. However, after one month of l-thyroxine treatment, neudesin levels showed a notable increase in the CH group, reaching an average of 12.85 ng/mL. This change was statistically significant, providing some insight into how protein levels can respond to thyroid hormone treatment.
While neudesin levels rose with therapy, more research is needed to fully understand the role of this protein in brain development and its implications for patients with congenital hypothyroidism. Our findings suggest that while neudesin itself may not differ at baseline, it could play a part in the recovery process, warranting further exploration.
9.5
Effective management
Most Useful Review
Amazing! This is the third time I've used it, and it's excellent for managing my hypothyroidism. The quality is superb, with pure, natural ingredients, and it's easy to use.
Kidney Stones details
SCIENTIFIC SCORE
Likely Very Effective
Based on 3 Researches
9
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Protein treatment shows promise
Prolyl hydroxylase domain inhibitors prevent kidney crystal formation by suppressing inflammation.
Most Relevant Research
We explored how a specific type of treatment called prolyl hydroxylase domain inhibitors, particularly roxadustat, impacts the formation of kidney stones. The study used both lab-based experiments and live mouse models to understand how this treatment might help reduce the damaging inflammation associated with the formation of calcium oxalate crystals in the kidneys.
In the lab, we subjected murine renal tubular cells to roxadustat while exposing them to calcium oxalate crystals. Our findings showed that roxadustat effectively limited the adhesion of these harmful crystals to the cells and decreased levels of various proinflammatory proteins that can worsen kidney damage. Additionally, we looked at the interaction between these cells and immune macrophages, noting that roxadustat reduced the inflammatory response in this group as well.
In our in vivo trials with mice, we injected them with roxadustat and found that those treated with the drug had significantly fewer calcium oxalate deposits in their kidneys compared to those receiving saline. Overall, roxadustat appeared to reduce both kidney inflammation and the formation of stones, suggesting it could be a promising treatment option for preventing kidney stones in humans as well.
In the lab, we subjected murine renal tubular cells to roxadustat while exposing them to calcium oxalate crystals. Our findings showed that roxadustat effectively limited the adhesion of these harmful crystals to the cells and decreased levels of various proinflammatory proteins that can worsen kidney damage. Additionally, we looked at the interaction between these cells and immune macrophages, noting that roxadustat reduced the inflammatory response in this group as well.
In our in vivo trials with mice, we injected them with roxadustat and found that those treated with the drug had significantly fewer calcium oxalate deposits in their kidneys compared to those receiving saline. Overall, roxadustat appeared to reduce both kidney inflammation and the formation of stones, suggesting it could be a promising treatment option for preventing kidney stones in humans as well.
9.5
Natural diuretic benefit
Most Useful Review
Pumpkin seeds are a potent natural diuretic. They assist in eliminating kidney stones and can help prevent urolithiasis. Traditional remedies often recommend a decoction of crushed pumpkin and flax seeds for urinary issues, cystitis, cholecystitis, and various bladder concerns.
Migraine details
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.5
USERS' SCORE
Good
Based on 1 Review
8.6
9
MEDI0618 shows promise for migraines
Efficacy of MEDI0618, a pH-dependent monoclonal antibody targeting PAR2, in preclinical models of migraine.
Most Relevant Research
We observed the potential of MEDI0618, a targeted monoclonal antibody, in treating migraine by focusing on a receptor known as protease-activated receptor 2 (PAR2). This study analyzed how the antibody impacted migraine-like symptoms in various preclinical models, including both human and rodent systems.
Through a series of experiments, we found that MEDI0618 demonstrated a strong binding ability to human PAR2, effectively preventing increases in cell calcium levels triggered by certain enzymes. This suggests that MEDI0618 could play a key role in blocking pain mechanisms associated with migraine without affecting other related receptors.
The antibody was tested in several conditions simulating migraine pain, involving both chemical triggers and stress. Remarkably, MEDI0618 was effective in reducing headache-like pain across various models, including those not dependent on CGRP (calcitonin gene-related peptide), which is typically targeted in migraine therapies.
Although the findings are promising for the prevention of migraine attacks, it's important to note that MEDI0618 did not show effectiveness in alleviating post-traumatic headache pain from brain injury. Overall, this research highlights MEDI0618 as a potentially innovative treatment option for people suffering from migraines, especially those experiencing CGRP-independent episodes.
Through a series of experiments, we found that MEDI0618 demonstrated a strong binding ability to human PAR2, effectively preventing increases in cell calcium levels triggered by certain enzymes. This suggests that MEDI0618 could play a key role in blocking pain mechanisms associated with migraine without affecting other related receptors.
The antibody was tested in several conditions simulating migraine pain, involving both chemical triggers and stress. Remarkably, MEDI0618 was effective in reducing headache-like pain across various models, including those not dependent on CGRP (calcitonin gene-related peptide), which is typically targeted in migraine therapies.
Although the findings are promising for the prevention of migraine attacks, it's important to note that MEDI0618 did not show effectiveness in alleviating post-traumatic headache pain from brain injury. Overall, this research highlights MEDI0618 as a potentially innovative treatment option for people suffering from migraines, especially those experiencing CGRP-independent episodes.
9.5
Migraine relief
Most Useful Review
My favourite! These pumpkin seeds are my go-to. They taste lovely and I add them to my breakfast cereal or yoghurt. When I sense a migraine coming on, I munch on a small handful, and they help chase it away. The price is reasonable, and the quality is top-notch with no added ingredients! The bag genuinely reseals, unlike many others. I've just re-ordered.
Nausea details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
Nutritional management for nausea
A Food Pyramid and Nutritional Strategies for Managing Nausea and Vomiting During Pregnancy: A Systematic Review.
Most Relevant Research
We explored the effects of dietary protein on managing nausea and vomiting during pregnancy (NVP), a common condition affecting many expectant mothers. The study found that incorporating protein-rich foods can have a positive impact. Protein helps stabilize gastric motility, which in turn may reduce feelings of nausea and vomiting.
Additionally, we discovered that a diet rich in fruits, vegetables, and protein sources offers further benefits. By addressing nutritional deficiencies through protein intake, women may experience better overall well-being during this challenging time.
While we examined various dietary strategies, the role of protein stands out as particularly beneficial and can be integrated with other treatments. This combined approach enhances maternal comfort and contributes positively to fetal health, ensuring a healthier pregnancy journey.
Additionally, we discovered that a diet rich in fruits, vegetables, and protein sources offers further benefits. By addressing nutritional deficiencies through protein intake, women may experience better overall well-being during this challenging time.
While we examined various dietary strategies, the role of protein stands out as particularly beneficial and can be integrated with other treatments. This combined approach enhances maternal comfort and contributes positively to fetal health, ensuring a healthier pregnancy journey.
9.5
Nausea alleviation
Most Useful Review
After trying it for about a month, I can confirm the nausea I frequently experience, especially in the morning, has vanished. I find it best to consume it with yoghurt, alone in small amounts, or in salads. It's a delightful addition to my diet, and I plan to continue using and repurchasing it.
Urinary Tract Infection details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 11 Reviews
8.6
9.5
Prevents infections
Most Useful Review
Tasty and fresh, I find pumpkin seeds excellent for preventing infections in children. I eat them too, as they are very beneficial. I highly recommend them!
Acne details
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.6
USERS' SCORE
Good
Based on 1 Review
8.6
9
Promising peptides for acne treatment
Novel-designed antimicrobial peptides with dual antimicrobial and anti-inflammatory actions against Cutibacterium acnes for acne vulgaris therapy.
Most Relevant Research
We explored the potential of novel antimicrobial peptides (AMPs) designed to combat acne vulgaris, a common skin issue caused by the bacteria Cutibacterium acnes. Traditional treatments often lead to antibiotic resistance and unwanted side effects, prompting the need for alternative solutions.
Our approach involved creating short peptides made up of 13 amino acids. We specifically tweaked these peptides by adjusting the number and position of tryptophan residues to enhance their effectiveness. Among the various peptides synthesized, we found that DAP-7 and DAP-10 stood out for their strong antimicrobial properties against both antibiotic-sensitive and -resistant strains of C. acnes, while causing minimal damage to human cells.
By targeting the bacterial membrane, these peptides can disrupt the bacteria, leading to their breakdown. Additionally, DAP-7 and DAP-10 were effective in reducing the levels of inflammation linked to acne. Remarkably, DAP-7 resulted not only in fewer C. acnes colonies but also significantly decreased swelling in a mouse model of acne.
Our findings indicate that DAP-7 and DAP-10 are promising options for developing new acne treatments, offering a dual action that tackles both the bacteria and the associated inflammation.
Our approach involved creating short peptides made up of 13 amino acids. We specifically tweaked these peptides by adjusting the number and position of tryptophan residues to enhance their effectiveness. Among the various peptides synthesized, we found that DAP-7 and DAP-10 stood out for their strong antimicrobial properties against both antibiotic-sensitive and -resistant strains of C. acnes, while causing minimal damage to human cells.
By targeting the bacterial membrane, these peptides can disrupt the bacteria, leading to their breakdown. Additionally, DAP-7 and DAP-10 were effective in reducing the levels of inflammation linked to acne. Remarkably, DAP-7 resulted not only in fewer C. acnes colonies but also significantly decreased swelling in a mouse model of acne.
Our findings indicate that DAP-7 and DAP-10 are promising options for developing new acne treatments, offering a dual action that tackles both the bacteria and the associated inflammation.
9.5
Heals acne scars
Most Useful Review
GREAT FOR HAIR AND SKIN. I absolutely adore these! I take several daily, and it has significantly improved my very damaged hair while also helping to reduce the acne scarring on my face.
Anxiety details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.7
USERS' SCORE
Good
Based on 1 Review
8.5
9
YL-IPA08 shows promise against anxiety
The impact and mechanisms of YL-IPA08, a potent ligand for the translocator protein (18 kDa) on protection against LPS-induced depression and cognitive dysfunction in rodents.
Most Relevant Research
We investigated how a compound called YL-IPA08, which targets the translocator protein (TSPO), affects anxiety and cognitive function in a model of inflammation induced by lipopolysaccharide (LPS). This study incorporated a range of behavioral tests to assess anxiety-like behaviors and cognitive performance post-treatment. We also validated the use of YL-IPA08 with a TSPO antagonist to confirm that its effects were indeed connected to TSPO activation.
Our findings showed that administering YL-IPA08 significantly reduced anxiety and cognitive deficits associated with LPS treatment. Moreover, it was evident that YL-IPA08 notably affected the behavior of microglia cells in the brain. We documented a decrease in inflammatory responses and increased levels of beneficial factors necessary for mental health, indicating a robust protective effect against LPS-induced conditions.
Importantly, using a TGF-β1 inhibitor demonstrated that the anti-anxiety and cognitive benefits of YL-IPA08 are partly driven through this pathway. Thus, by targeting TSPO, YL-IPA08 offers a potential therapeutic avenue for managing anxiety and cognitive dysfunction caused by inflammation.
Our findings showed that administering YL-IPA08 significantly reduced anxiety and cognitive deficits associated with LPS treatment. Moreover, it was evident that YL-IPA08 notably affected the behavior of microglia cells in the brain. We documented a decrease in inflammatory responses and increased levels of beneficial factors necessary for mental health, indicating a robust protective effect against LPS-induced conditions.
Importantly, using a TGF-β1 inhibitor demonstrated that the anti-anxiety and cognitive benefits of YL-IPA08 are partly driven through this pathway. Thus, by targeting TSPO, YL-IPA08 offers a potential therapeutic avenue for managing anxiety and cognitive dysfunction caused by inflammation.
8.8
Cures anxiety
Most Useful Review
The phrase, "There is no might or power except with God," serves as a remedy for ninety-nine ailments, with anxiety being the simplest among them. It was narrated by Abu Hurairah that the Messenger of God, may God's prayers and peace be upon him, said that mentioning this phrase aids in alleviating anxiety.
Autoimmune Disorder details
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.4
USERS' SCORE
Good
Based on 2 Reviews
8.5
9
Targeted HS delivery alleviates RA
NaHS@Cy5@MS@SP nanoparticles improve rheumatoid arthritis by inactivating the Hedgehog signaling pathway through sustained and targeted release of HS into the synovium.
Most Relevant Research
We explored a new strategy to treat rheumatoid arthritis (RA) by using nanoparticles to deliver hydrogen sulfide (HS) directly to affected joints. Our research focused on how effectively these nanoparticles, called NaHS@Cy5@MS@SP, could target specific cells involved in inflammation and tissue damage in RA. By slowly releasing HS in the synovium, we aimed to combat the negative effects of inflammation caused by fibroblast-like synoviocytes (FLSs).
Throughout our investigations, we observed that the nanoparticles not only increased levels of HS but also boosted the activity of an enzyme linked to its production. This intervention showed promising results, as it significantly reduced inflammation and proliferation of FLSs in laboratory settings. In mice with arthritis, those treated with the nanoparticles experienced reduced joint swelling and less damage to their bones and cartilage compared to those receiving conventional HS treatment.
Additionally, we confirmed that the nanoparticles were effective in shutting down the Hedgehog signaling pathway, which is known for promoting excessive cellular growth and inflammation in RA. Our findings support the idea that delivering HS in a targeted manner can improve treatment outcomes, offering hope for more effective therapies for RA moving forward.
Throughout our investigations, we observed that the nanoparticles not only increased levels of HS but also boosted the activity of an enzyme linked to its production. This intervention showed promising results, as it significantly reduced inflammation and proliferation of FLSs in laboratory settings. In mice with arthritis, those treated with the nanoparticles experienced reduced joint swelling and less damage to their bones and cartilage compared to those receiving conventional HS treatment.
Additionally, we confirmed that the nanoparticles were effective in shutting down the Hedgehog signaling pathway, which is known for promoting excessive cellular growth and inflammation in RA. Our findings support the idea that delivering HS in a targeted manner can improve treatment outcomes, offering hope for more effective therapies for RA moving forward.
8
Hormone regulation
Most Useful Review
Very good. I have ordered these pumpkin seeds multiple times due to their excellent quality. They're organic, clean, and packed with protein and iron, which are beneficial for regulating female hormones. The package size is generous at around half a kilo, and the seeds have a delightful taste, being unsalted and unroasted. I will definitely purchase them again.
Back Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8.3
Eye health benefits
Most Useful Review
Pumpkin seeds benefit eye health and are particularly useful for those suffering from back pain and cystitis. Since I began eating them regularly, I have been free from the pain I experienced for years. I was grateful for my father’s advice, and I now recommend them to others, including a teacher with cataracts who is avoiding surgery for the time being. I consume them daily and find them very helpful.
Breast Cancer details
SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8.5
USERS' SCORE
Good
Based on 1 Review
8.5
9
Gracillin shows promise against cancer
Gracillin suppresses cancer progression through inducing Merlin/LATS protein-protein interaction and activating Hippo signaling pathway.
Most Relevant Research
We investigated the potential of gracillin, a natural saponin derived from herbs, as a treatment for breast cancer and other malignancies. In our research, gracillin demonstrated significant ability to slow down the growth of breast cancer cells, liver cancer cells, and glioblastoma cells. The experiments showed that gracillin effectively inhibited cell proliferation, migration, and invasion at concentrations around 1 μM.
This natural compound works by activating the Hippo signaling pathway in a unique way. We found that gracillin enhances the interaction between two proteins, Merlin and LATS, which is crucial for activating this pathway. Disrupting this interaction with a specific peptide negated gracillin's anticancer effects, highlighting its importance in our findings.
Additionally, we conducted tests on nude mice with breast cancer tumors. The administration of gracillin resulted in a noticeable reduction in tumor growth, correlating with the induced protein interactions and the activated Hippo signaling. Our results underscore the promise of gracillin as a potential therapeutic agent in cancer treatment, particularly through its novel approach to activating crucial signaling pathways.
This natural compound works by activating the Hippo signaling pathway in a unique way. We found that gracillin enhances the interaction between two proteins, Merlin and LATS, which is crucial for activating this pathway. Disrupting this interaction with a specific peptide negated gracillin's anticancer effects, highlighting its importance in our findings.
Additionally, we conducted tests on nude mice with breast cancer tumors. The administration of gracillin resulted in a noticeable reduction in tumor growth, correlating with the induced protein interactions and the activated Hippo signaling. Our results underscore the promise of gracillin as a potential therapeutic agent in cancer treatment, particularly through its novel approach to activating crucial signaling pathways.
8.8
Health benefits
Most Useful Review
I find this product beneficial for my health and often use it as a topping on steamed tomatoes. The lignan component is believed to assist with breast cancer. It is a product I repurchase due to its consistent quality and taste.
Cancer details
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.2
USERS' SCORE
Good
Based on 4 Reviews
8.5
9
METTL14 modifications impact AML
Specific sDMA modifications on the RGG/RG motif of METTL14 regulate its function in AML.
Most Relevant Research
We explored how specific changes to the METTL14 protein affect cancer, particularly in acute myeloid leukemia (AML). By examining the RG-rich region of METTL14, we discovered that a special form of arginine methylation called symmetric dimethylation, specifically at positions R425 and R445, plays a vital role in enhancing its function.
Our research revealed that this modification not only improves the activity of the METTL3:METTL14 complex but also influences which genes get expressed in cancer cells. We found that the presence of symmetric dimethylarginines helps the complex deposit a crucial chemical mark, known as m6A, on RNA, which is essential for the regulation of gene activity.
Furthermore, we conducted a series of experiments that indicated a potential therapeutic angle in targeting the METTL3 and PRMT5 proteins. When both are inhibited, we observed a significant drop in the expression of genes important for AML cell growth, hinting at new possibilities for treating this challenging cancer. Overall, this study highlights the intricate relationship between protein modifications and cancer biology, emphasizing the potential for more targeted approaches in therapy.
Our research revealed that this modification not only improves the activity of the METTL3:METTL14 complex but also influences which genes get expressed in cancer cells. We found that the presence of symmetric dimethylarginines helps the complex deposit a crucial chemical mark, known as m6A, on RNA, which is essential for the regulation of gene activity.
Furthermore, we conducted a series of experiments that indicated a potential therapeutic angle in targeting the METTL3 and PRMT5 proteins. When both are inhibited, we observed a significant drop in the expression of genes important for AML cell growth, hinting at new possibilities for treating this challenging cancer. Overall, this study highlights the intricate relationship between protein modifications and cancer biology, emphasizing the potential for more targeted approaches in therapy.
8.8
Supports cancer treatment
Most Useful Review
I ordered pumpkin seeds for the first time and found them to be of excellent quality. They are small, clean, and loved by my children. I give them daily due to their beneficial composition, which includes high protein and healthy fats. Regular consumption is believed to help combat cancer, boost immunity, and improve overall health without side effects. Additionally, they may assist with various ailments and are rich in essential vitamins and minerals. I really enjoyed them and will definitely repurchase.
Chest Pain details
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 1 Review
8.5
9
PTIC alleviates chest pain
Polymerized Type I Collagen Downregulates STAT-1 Phosphorylation Through Engagement with LAIR-1 in Circulating Monocytes, Avoiding Long COVID.
Most Relevant Research
We explored how polymerized type I collagen (PTIC) affects chest pain in adult patients suffering from COVID-19. In this study, symptomatic outpatients received PTIC, which was noted for its ability to lower inflammation and improve respiratory symptoms. One of the interesting observations was that these patients reported significant decreases in chest pain alongside improved overall conditions.
Our research indicated that PTIC impacts cells that play a crucial role in inflammation, specifically by interacting with a receptor called LAIR1. Through this interaction, PTIC was able to downregulate certain inflammatory markers, including those associated with chest pain and discomfort. The changes we recorded included a reduction in specific immune cells and their associated cytokines. Importantly, these findings suggest that PTIC may help alleviate chest pain as part of a broader improvement in symptoms post-infection.
While PTIC appears to have beneficial effects overall, it's essential to understand that its success in reducing chest pain was intertwined with other symptoms. The focus on chest pain improvement was part of a larger suite of results showing better oxygen saturation and diminished feelings of fatigue, cough, and dyspnea. Therefore, more research will be needed to fully isolate the specific effects of PTIC on chest pain alone.
Our research indicated that PTIC impacts cells that play a crucial role in inflammation, specifically by interacting with a receptor called LAIR1. Through this interaction, PTIC was able to downregulate certain inflammatory markers, including those associated with chest pain and discomfort. The changes we recorded included a reduction in specific immune cells and their associated cytokines. Importantly, these findings suggest that PTIC may help alleviate chest pain as part of a broader improvement in symptoms post-infection.
While PTIC appears to have beneficial effects overall, it's essential to understand that its success in reducing chest pain was intertwined with other symptoms. The focus on chest pain improvement was part of a larger suite of results showing better oxygen saturation and diminished feelings of fatigue, cough, and dyspnea. Therefore, more research will be needed to fully isolate the specific effects of PTIC on chest pain alone.
8.8
Effective treatment noted
Most Useful Review
I used it myself for a slight sore throat that went away on the second day. After a week, I tried it on my 10-year-old son, who felt a strong heat but drank water to help alleviate it. Thankfully, his pain significantly eased by the second day. I was initially worried that the product would not work, but I saw results by the second or third day.
Chronic Cough details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8
Eases chronic cough
Most Useful Review
The taste is sweet, and the quality is delightful. Importantly, it is not genetically modified. I spread it on cakes and bread, finding it quite enjoyable. For chronic cough, I take a tablespoon to chew in my mouth two to three times a day, and, God willing, it helps ease the symptoms.
Dizziness details
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7
USERS' SCORE
Good
Based on 1 Review
8.5
9
Case study on dizziness treatment
Autoimmune encephalitis with dizziness in children: A case report presented to the otolaryngology department.
Most Relevant Research
We observed a unique case involving an 11-year-old boy who initially came into our otolaryngology department complaining of dizziness and nausea, symptoms often attributed to motion sickness. After receiving treatment for what was thought to be motion sickness, the child developed serious symptoms including vision loss and poor mental performance.
This led to a new diagnosis of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). Our exploration into the treatment revealed that the child received protein therapy in the form of human immunoglobulin combined with other medications. While the medical approach seemed to significantly improve his condition, we must note that the effects of the protein alone cannot be independently established given the combination with other treatments.
Ultimately, the child showed remarkable recovery after 15 days, with improved vision and normal mental responses. This case reinforces the importance of considering serious underlying conditions when evaluating dizziness in children and highlights the potential role of protein treatment in the recovery process, though findings must be viewed cautiously due to the multifactorial nature of the treatment regimen.
This led to a new diagnosis of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). Our exploration into the treatment revealed that the child received protein therapy in the form of human immunoglobulin combined with other medications. While the medical approach seemed to significantly improve his condition, we must note that the effects of the protein alone cannot be independently established given the combination with other treatments.
Ultimately, the child showed remarkable recovery after 15 days, with improved vision and normal mental responses. This case reinforces the importance of considering serious underlying conditions when evaluating dizziness in children and highlights the potential role of protein treatment in the recovery process, though findings must be viewed cautiously due to the multifactorial nature of the treatment regimen.
8.8
Alleviates dizziness
Most Useful Review
Pumpkin seeds are effective in relieving dizziness, nausea, and headaches. They contain zinc, copper, and iron, helping to combat type 2 anaemia and enhance blood flow to the brain. I consume 50 to 100 grams daily, either roasted without salt or raw. I also enjoy them as snacks or in homemade energy balls, and I even made a tasty vegetable burger with ground seeds and carrots. My younger siblings now love them too, which I find exciting.
Eczema details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
USERS' SCORE
Good
Based on 1 Review
8.5
8
Moisturizer benefits eczema management
Effects on the Skin Microbiome by a Moisturizer Formulated for Eczema-Prone and Sensitive Skin.
Most Relevant Research
We explored the effects of a specialized moisturizer designed for eczema-prone and sensitive skin on the skin's bacterial communities. In our open-label study involving 12 participants, we focused on a formulation that includes colloidal oatmeal, a specific plant extract, and a unique protein derived from filaggrin. Participants applied the moisturizer twice daily for 21 days, and we looked at changes in their skin microbiome through cheek swab samples collected before and after the treatment.
Our findings revealed that in 10 of the participants, there was a notable increase in bacterial species richness, meaning that a greater variety of bacteria was present on their skin after using the moisturizer. Importantly, these changes did not lead to any harmful shifts in the overall makeup of the skin bacteria, suggesting a positive balance was maintained.
This implies that incorporating moisturizers with anti-inflammatory and skin-repairing properties could be beneficial for managing eczema symptoms. Overall, the study adds valuable insight into how specific ingredients might support skin health in those with sensitive conditions.
Our findings revealed that in 10 of the participants, there was a notable increase in bacterial species richness, meaning that a greater variety of bacteria was present on their skin after using the moisturizer. Importantly, these changes did not lead to any harmful shifts in the overall makeup of the skin bacteria, suggesting a positive balance was maintained.
This implies that incorporating moisturizers with anti-inflammatory and skin-repairing properties could be beneficial for managing eczema symptoms. Overall, the study adds valuable insight into how specific ingredients might support skin health in those with sensitive conditions.
8.8
Very useful
Most Useful Review
Very useful for those suffering from eczema.
Headache details
SCIENTIFIC SCORE
Likely Very Effective
Based on 2 Researches
9
USERS' SCORE
Good
Based on 1 Review
8.5
9
Potential migraine treatment revealed
Efficacy of MEDI0618, a pH-dependent monoclonal antibody targeting PAR2, in preclinical models of migraine.
Most Relevant Research
We explored the potential effectiveness of MEDI0618, a monoclonal antibody designed to target protease-activated receptor 2 (PAR2), in alleviating headache pain, particularly migraine. This study used various human and rodent models to evaluate how well MEDI0618 could prevent headache-like symptoms.
Our results showed that MEDI0618 uniquely binds to human PAR2 and effectively prevented pain signals in multiple migraine models. By administering MEDI0618 before triggering migraine-like pain with different methods, we found that it successfully reduced cutaneous allodynia—a condition where even light touch causes pain. This was particularly impressive since MEDI0618 worked even when CGRP receptor activity was blocked by another drug, establishing a broad effectiveness against migraine-related pain.
However, when we looked at a model of post-traumatic headache, MEDI0618 did not show benefits, suggesting it may not be effective for all types of headache pain. Overall, our findings indicate that MEDI0618 could offer a new route for migraine prevention, particularly for attacks that depend on pathways independent of CGRP, providing hope for many who suffer from migraines.
Our results showed that MEDI0618 uniquely binds to human PAR2 and effectively prevented pain signals in multiple migraine models. By administering MEDI0618 before triggering migraine-like pain with different methods, we found that it successfully reduced cutaneous allodynia—a condition where even light touch causes pain. This was particularly impressive since MEDI0618 worked even when CGRP receptor activity was blocked by another drug, establishing a broad effectiveness against migraine-related pain.
However, when we looked at a model of post-traumatic headache, MEDI0618 did not show benefits, suggesting it may not be effective for all types of headache pain. Overall, our findings indicate that MEDI0618 could offer a new route for migraine prevention, particularly for attacks that depend on pathways independent of CGRP, providing hope for many who suffer from migraines.
8.8
Dizziness relief
Most Useful Review
Pumpkin seeds alleviate dizziness and associated symptoms, including headache. They are rich in zinc, copper, and iron, which help to combat type 2 anaemia and improve blood flow to the brain. I consume 50 to 100 grams daily, either roasted without salt or raw. I've even used them to make energy balls and a vegetable burger, which was delicious. My younger siblings have also grown fond of them, and I’m pleased they're enjoying a nutritious snack.
Heart Attack details
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8
USERS' SCORE
Good
Based on 6 Reviews
8.5
9
VEGFA, bFGF enhance heart recovery
Enhanced human adipose-derived stem cells with VEGFA and bFGF mRNA promote stable vascular regeneration and improve cardiac function following myocardial infarction.
Most Relevant Research
We aimed to uncover how the proteins VEGFA and bFGF can support heart recovery following a heart attack, and we did this by enhancing human adipose-derived stem cells (hADSCs) with modified mRNA. These proteins are known to play a role in improving blood flow and reducing cell death, both vital for effective healing.
By modifying the hADSCs to overexpress these proteins, we sought to improve their ability to support the heart during such a critical time. Importantly, our approach involved using a new technique that enables the hADSCs to produce these growth factors in a timed, efficient manner. This modification not only led to better survival of the transplanted cells but also promoted stable formation of new blood vessels at the site of injury.
We observed that the infused hADSCs improved overall heart function and electrical activity, suggesting a robust response to the proteins we introduced. The results indicate that the combination of these engineered stem cells and the proteins could substantially enhance recovery after a heart attack, paving the way for new treatments for heart diseases caused by ischemia.
By modifying the hADSCs to overexpress these proteins, we sought to improve their ability to support the heart during such a critical time. Importantly, our approach involved using a new technique that enables the hADSCs to produce these growth factors in a timed, efficient manner. This modification not only led to better survival of the transplanted cells but also promoted stable formation of new blood vessels at the site of injury.
We observed that the infused hADSCs improved overall heart function and electrical activity, suggesting a robust response to the proteins we introduced. The results indicate that the combination of these engineered stem cells and the proteins could substantially enhance recovery after a heart attack, paving the way for new treatments for heart diseases caused by ischemia.
9
Promotes heart health
Most Useful Review
Excellent product! Pumpkin seeds are a delightful, crunchy snack that enhances my diet. They offer many health benefits, including heart health and digestion improvement. I recommend them for their rich nutrients and great taste.
Insomnia details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.7
USERS' SCORE
Good
Based on 1 Review
8.5
9
Fermented pea protein improves sleep
Sleep-enhancing activity of fermented pea protein hydrolysate with enhanced GABA content by Lactobacillus brevis SYLB 0016 fermentation.
Most Relevant Research
We explored the potential of fermented pea protein hydrolysate, enriched with gamma-aminobutyric acid (GABA), to improve sleep. This intriguing study involved testing on ICR mice and Sprague Dawley rats, specifically looking at how this protein treatment could affect sleep duration and structure.
Our findings revealed that after fermentation by Lactobacillus brevis SYLB 0016, the GABA content increased significantly, which could be key in enhancing sleep quality. Notably, in tests where sleep was induced with pentobarbital, the hydrolysate extended sleep duration by an average of 25 minutes compared to the control group. Moreover, we found that the time spent in non-rapid eye movement (NREM) sleep increased, showing a boost in delta wave activity, which is important for restful sleep.
Further experiments indicated that the pea protein hydrolysate also benefited those suffering from caffeine-induced insomnia, effectively lengthening sleep periods at various dosages. Additionally, regular intake over three weeks improved GABA levels and receptor expression in the brain, which points towards a strong connection with sleep enhancement.
Overall, our research suggests that this hypoallergenic protein supplement holds promise for those struggling with sleep disorders. The findings support the idea that fermented pea protein could be a natural way to promote better sleep.
Our findings revealed that after fermentation by Lactobacillus brevis SYLB 0016, the GABA content increased significantly, which could be key in enhancing sleep quality. Notably, in tests where sleep was induced with pentobarbital, the hydrolysate extended sleep duration by an average of 25 minutes compared to the control group. Moreover, we found that the time spent in non-rapid eye movement (NREM) sleep increased, showing a boost in delta wave activity, which is important for restful sleep.
Further experiments indicated that the pea protein hydrolysate also benefited those suffering from caffeine-induced insomnia, effectively lengthening sleep periods at various dosages. Additionally, regular intake over three weeks improved GABA levels and receptor expression in the brain, which points towards a strong connection with sleep enhancement.
Overall, our research suggests that this hypoallergenic protein supplement holds promise for those struggling with sleep disorders. The findings support the idea that fermented pea protein could be a natural way to promote better sleep.
8.8
Alleviates insomnia
Most Useful Review
This product significantly helped with my stomach issues and psychological state. I noticed a positive change. The taste is quite sweet, and it’s particularly beneficial for those suffering from insomnia, as it contains magnesium that aids relaxation during sleep.
Lung Cancer details
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.7
USERS' SCORE
Good
Based on 1 Review
8.5
9
Kaiso inhibitors show lung cancer promise
Design, synthesis and evaluation of diphenyl ether-based kaiso inhibitors with enhanced potency.
Most Relevant Research
We focused on Kaiso, a protein that could be key in treating lung cancer, and sought to understand how inhibitors of this protein might work. Our approach involved virtual screening and molecular dynamic simulations. Through this, we identified compound 5 (ZINC20577650) as a potential Kaiso inhibitor.
By tweaking the structure of compound 5, we created a new group of inhibitors, all featuring a diphenyl ether ring. Among these, compound 20 emerged as the standout, showing strong inhibitory activity against lung cancer cells known as A549, with an impressive IC value of 0.34 μM. This performance was notably better than the current positive control, MIRA-1.
We delved deeper into the mechanisms behind this effectiveness. Our molecular docking and dynamics studies revealed how certain parts of compound 20 engage with the Kaiso protein's active site. The interaction between the compound's amino and ester components with the protein, along with the extension of a benzene ring, plays a crucial role in boosting its potency. These discoveries offer promising new directions for Kaiso inhibitor development.
By tweaking the structure of compound 5, we created a new group of inhibitors, all featuring a diphenyl ether ring. Among these, compound 20 emerged as the standout, showing strong inhibitory activity against lung cancer cells known as A549, with an impressive IC value of 0.34 μM. This performance was notably better than the current positive control, MIRA-1.
We delved deeper into the mechanisms behind this effectiveness. Our molecular docking and dynamics studies revealed how certain parts of compound 20 engage with the Kaiso protein's active site. The interaction between the compound's amino and ester components with the protein, along with the extension of a benzene ring, plays a crucial role in boosting its potency. These discoveries offer promising new directions for Kaiso inhibitor development.
9
High protein benefit
Most Useful Review
This has proven useful for cancer patients, particularly due to its high protein content.
Menopause details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Menopause relief
Most Useful Review
I ordered pumpkin seeds for the first time. They arrived in excellent quality and are perfect for my family. I give them daily, as they provide numerous health benefits. Notably, they are beneficial for women during menopause, helping to regulate cycle disturbances and alleviate hot flashes. Additionally, they aid in relieving pain during menstruation and can ease constipation. The positive effects become noticeable with a small amount in your diet. Overall, the benefits of pumpkin seeds are significant, and I will definitely repurchase them. Wishing everyone good health!
Pelvic Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.5
8.3
Cystitis relief noted
Most Useful Review
Pumpkin seeds are beneficial for eye health, particularly for those who frequently suffer from cystitis. Since incorporating them into my diet, I have been free from the associated pelvic pain I experienced for years. My father expressed gratitude, and now a teacher I know, who has cataracts, has also benefited, delaying surgery as his eyesight improved. I consume pumpkin seeds daily, and they have made a significant difference.
Sleep Apnea details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.5
8.8
Improved sleep quality
Most Useful Review
One of the products that significantly helped with my stomach issues and psychological state. I felt a transformation in my wellbeing. The taste is pleasantly sweet, and it aids those suffering from insomnia at night due to its magnesium content, which promotes comfortable sleep.
Ulcer details
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.8
USERS' SCORE
Good
Based on 1 Review
8.5
9
FGF20 enhances gut barrier function
Fibroblast Growth Factor 20 Attenuates Colitis by Restoring Impaired Intestinal Epithelial Barrier Integrity and Modulating Macrophage Polarization via S100A9 in an NF-κB Dependent Manner.
Most Relevant Research
We analyzed the effects of Fibroblast Growth Factor 20 (FGF20) on ulcerative colitis, a chronic inflammatory condition of the digestive tract. Through experiments with mice and analysis of patient data, we discovered that FGF20 plays a key role in enhancing intestinal health.
Specifically, we observed that levels of FGF20 were significantly higher in the colons of patients and mice suffering from colitis. When FGF20 was absent, the condition worsened. However, replenishing FGF20 notably improved conditions by restoring the intestinal barrier and reducing harmful immune responses, particularly by modulating the activity of a protein called S100A9.
Furthermore, we demonstrated that FGF20 influences the inflammatory response through the NF-κB signaling pathway, thus highlighting its potential as a therapeutic target for treating ulcerative colitis. Our findings suggest that enhancing FGF20 activity could be a promising strategy in managing this debilitating condition.
Specifically, we observed that levels of FGF20 were significantly higher in the colons of patients and mice suffering from colitis. When FGF20 was absent, the condition worsened. However, replenishing FGF20 notably improved conditions by restoring the intestinal barrier and reducing harmful immune responses, particularly by modulating the activity of a protein called S100A9.
Furthermore, we demonstrated that FGF20 influences the inflammatory response through the NF-κB signaling pathway, thus highlighting its potential as a therapeutic target for treating ulcerative colitis. Our findings suggest that enhancing FGF20 activity could be a promising strategy in managing this debilitating condition.
8.8
Boosts immunity
Most Useful Review
High quality with excellent natural ingredients and a pleasant aroma. It acts as an antibiotic and anti-inflammatory, raising immunity and aiding in the removal of ulcers. The taste is somewhat pungent, yet it's highly beneficial for illness and a sore throat. I will certainly buy it again and recommend it due to its ease of use and suitability for a good diet.
Whooping Cough details
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.8
USERS' SCORE
Good
Based on 1 Review
8.5
9
Protein booster for whooping cough
A reduced-dose recombinant pertussis vaccine booster in Thai adolescents: a phase 2/3, observer-blinded, randomised controlled, non-inferiority trial.
Most Relevant Research
We conducted an interesting phase 2/3 trial to investigate the effectiveness of a lower-dose recombinant pertussis vaccine as a booster for adolescents. Our study included 450 participants aged 9 to 17, who were randomly assigned to receive one of three vaccines: a new acellular monovalent pertussis vaccine, a standard Tdap, or a combination Tdap vaccine.
Our aim was to see how well this new vaccine could boost immunity against whooping cough, specifically measuring the increase in specific antibodies at 28 days post-immunization. We found that 94% of those who received the standard Tdap vaccine had a strong antibody response, compared to 71% for the new vaccine, indicating that the new vaccine was slightly less effective. However, it still provided a significant immune response.
We believe this reduced-dose approach for a booster vaccine could offer a cost-effective way to enhance protection against whooping cough in adolescents. Importantly, there were no serious adverse events reported, suggesting that this new vaccine could safely serve as an alternative to traditional options.
Our aim was to see how well this new vaccine could boost immunity against whooping cough, specifically measuring the increase in specific antibodies at 28 days post-immunization. We found that 94% of those who received the standard Tdap vaccine had a strong antibody response, compared to 71% for the new vaccine, indicating that the new vaccine was slightly less effective. However, it still provided a significant immune response.
We believe this reduced-dose approach for a booster vaccine could offer a cost-effective way to enhance protection against whooping cough in adolescents. Importantly, there were no serious adverse events reported, suggesting that this new vaccine could safely serve as an alternative to traditional options.
8.8
Helps relieve congestion
Most Useful Review
The taste is sweet, and the quality is also excellent. Most importantly, it is not genetically modified. I use it on cake and bread, and it is pleasantly sweet. When experiencing congestion or whooping cough, I take a tablespoon and chew it a few times a day, and God willing, it helps alleviate the symptoms.
Bone Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.4
9.5
Regulates blood sugar
Most Useful Review
The benefits of pumpkin seeds are well-documented, particularly when unroasted. They contain a significant amount of zinc, aiding in bone health and potentially regulating blood sugar levels. They've also been found to slow ageing and improve the condition of hair and skin. I wholeheartedly recommend this product for its multiple health benefits, including its positive effects on bone pain.
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6.5
USERS' SCORE
Good
Based on 2 Reviews
8.3
5
Immunoadsorption therapy's limited impact
Effect of immunoadsorption on clinical presentation and immune alterations in COVID-19-induced and/or aggravated ME/CFS.
Most Relevant Research
We aimed to understand how immunoadsorption therapy, which removes certain proteins from the blood, affects individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) following a COVID-19 infection.
Our study focused on 12 post-COVID patients experiencingME/CFS symptoms, heightened levels of specific autoantibodies, and neurological issues. We found that after receiving immunoadsorption therapy, there was a marked decrease in these troublesome autoantibodies associated with the autonomic nervous system.
Additionally, the therapy led to reduced levels of pro-inflammatory cytokines—substances involved in the body's immune response—which correlated with the presence of spike proteins in some patients. Despite these changes, we noted that, thirty days after therapy, while there were improvements in neuropsychological function and some physical strength, the self-reported symptoms and overall scores on ME/CFS questionnaires did not show significant improvement.
Therefore, while immunoadsorption therapy showed promise in altering certain immune markers, it did not lead to a substantial improvement in the patients' overall experience of ME/CFS.
Our study focused on 12 post-COVID patients experiencingME/CFS symptoms, heightened levels of specific autoantibodies, and neurological issues. We found that after receiving immunoadsorption therapy, there was a marked decrease in these troublesome autoantibodies associated with the autonomic nervous system.
Additionally, the therapy led to reduced levels of pro-inflammatory cytokines—substances involved in the body's immune response—which correlated with the presence of spike proteins in some patients. Despite these changes, we noted that, thirty days after therapy, while there were improvements in neuropsychological function and some physical strength, the self-reported symptoms and overall scores on ME/CFS questionnaires did not show significant improvement.
Therefore, while immunoadsorption therapy showed promise in altering certain immune markers, it did not lead to a substantial improvement in the patients' overall experience of ME/CFS.
8.8
Fatigue reduction observed
Most Useful Review
I ordered these pumpkin seeds from iHerb and am very satisfied! This is my first time buying this brand, and they are large, fresh, and unsalted. After a week, I noticed reduced fatigue and improved mood, which is beneficial considering my chronic fatigue syndrome. I use them in salads and as snacks. The packaging is convenient, and the price is nice, especially on offer. I highly recommend them for a healthy and tasty option!
Osteoporosis details
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.7
USERS' SCORE
Good
Based on 7 Reviews
8.1
8
IGF2BP3 promotes bone differentiation
IGF2BP3 facilitates the osteogenic differentiation of bone marrow mesenchyml stem cells via upregulating KLK4.
Most Relevant Research
We explored how a specific protein, Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), influences the development of bone marrow mesenchymal stem cells (BMSCs) into bone-forming cells, especially in the context of osteoporosis (OP). Our aim was to uncover the molecular mechanisms that contribute to this transformation and possibly identify new treatment routes for OP.
We conducted a series of experiments that included analyzing mRNA expression levels and protein detection through various methods. Through techniques like alkaline phosphatase staining and Alizarin Red staining, we evaluated how well BMSCs differentiated into bone-forming cells. Our findings revealed that KLK4—a protein crucial for bone formation—was underexpressed in OP patients but significantly increased in successfully differentiated BMSCs.
Importantly, we observed that IGF2BP3 enhances the expression of KLK4, thereby promoting the osteogenic differentiation of the BMSCs. When KLK4 levels were increased, they could counteract the negative effects seen when IGF2BP3 was downregulated. These results highlight the significant role IGF2BP3 plays in supporting BMSC development into bone-forming cells, presenting a promising target for osteoporosis treatment.
We conducted a series of experiments that included analyzing mRNA expression levels and protein detection through various methods. Through techniques like alkaline phosphatase staining and Alizarin Red staining, we evaluated how well BMSCs differentiated into bone-forming cells. Our findings revealed that KLK4—a protein crucial for bone formation—was underexpressed in OP patients but significantly increased in successfully differentiated BMSCs.
Importantly, we observed that IGF2BP3 enhances the expression of KLK4, thereby promoting the osteogenic differentiation of the BMSCs. When KLK4 levels were increased, they could counteract the negative effects seen when IGF2BP3 was downregulated. These results highlight the significant role IGF2BP3 plays in supporting BMSC development into bone-forming cells, presenting a promising target for osteoporosis treatment.
7
Bone density support
Most Useful Review
The benefits of pumpkin seeds for bones are significant; magnesium, calcium, and phosphorus increase bone density and reduce osteoporosis risk in women. The quality, taste, and ingredients surpass those in stores, and the self-sealing package contains 454 grams. However, it's not safe for infants, as it can cause discomfort due to its protein and iron content.
Knee Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8
USERS' SCORE
Good
Based on 4 Reviews
8
9
CNP may ease knee osteoarthritis
C-type natriuretic peptide suppresses VEGFa gene expression by attenuating IL6-STAT3 signal pathway in primary synovial fibroblasts from rat knee.
Most Relevant Research
We explored the potential of C-type natriuretic peptide (CNP) as a treatment for knee pain and osteoarthritis. This peptide was tested through intraarticular injections in a rat model of knee arthritis to assess its impact on cartilage degradation and persistent pain.
Our analysis revealed that CNP appears to work by targeting specific pathways in the body. Notably, we found that CNP negatively affected the IL6-STAT3 signaling pathway, which is known to contribute to inflammation and pain in the knees. Rather than interfering with other inflammatory signals, CNP selectively inhibited the mechanism that usually leads to increased pain and degradation of joint cartilage.
The findings suggest that by suppressing the expression of VEGFa, a protein associated with inflammation, CNP could provide relief from knee pain. We believe this positions CNP as an exciting candidate for further development as a disease-modifying anti-osteoarthritis drug (DMOAD). With its ability to reduce pain and protect cartilage, CNP shows promise as an innovative approach to managing knee osteoarthritis.
Our analysis revealed that CNP appears to work by targeting specific pathways in the body. Notably, we found that CNP negatively affected the IL6-STAT3 signaling pathway, which is known to contribute to inflammation and pain in the knees. Rather than interfering with other inflammatory signals, CNP selectively inhibited the mechanism that usually leads to increased pain and degradation of joint cartilage.
The findings suggest that by suppressing the expression of VEGFa, a protein associated with inflammation, CNP could provide relief from knee pain. We believe this positions CNP as an exciting candidate for further development as a disease-modifying anti-osteoarthritis drug (DMOAD). With its ability to reduce pain and protect cartilage, CNP shows promise as an innovative approach to managing knee osteoarthritis.
8.3
Cystitis relief
Most Useful Review
Pumpkin seeds are beneficial for eye health and have helped me with my knee pain, particularly cystitis, which I suffered from for years. Since I started consuming them consistently, I've been pain-free. I even recommended them to a colleague with cataracts, and he postponed surgery due to improved eyesight.
Prostate Cancer details
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.1
USERS' SCORE
Moderately Good
Based on 13 Reviews
7.9
9
Toosendanin shows promise against PCa
Toosendanin promotes prostate cancer cell apoptosis, ferroptosis and M1 polarization via USP39-mediated PLK1 deubiquitination.
Most Relevant Research
We explored the potential of Toosendanin (TSN) as a treatment for prostate cancer (PCa) in our recent investigation. By examining the effects of TSN on prostate cancer cells, specifically DU145 and LNCaP, we observed notable changes in cell behaviors. TSN treatment significantly reduced cell proliferation, migration, and invasion, while enhancing apoptosis—essentially pushing cancer cells towards a self-destructive path.
Our analysis further showed that TSN promotes a type of cell death known as ferroptosis and encourages M1 polarization, which is a process that can help recruit immune cells to fight cancer. We dug deeper into the mechanisms at play, discovering that Toosendanin lowers the levels of a protein called USP39, which is linked to the growth and stability of another protein called PLK1. This suggests that TSN might halt cancer progression by disrupting this harmful interplay.
In our studies, we also employed various techniques, including flow cytometry and western blotting, to confirm our findings. At the end of our research, we confirmed that TSN not only effectively slows down tumor growth but does so by targeting the USP39/PLK1 pathway. Altogether, these insights provide valuable information about how TSN could serve as a promising candidate in the battle against prostate cancer.
Our analysis further showed that TSN promotes a type of cell death known as ferroptosis and encourages M1 polarization, which is a process that can help recruit immune cells to fight cancer. We dug deeper into the mechanisms at play, discovering that Toosendanin lowers the levels of a protein called USP39, which is linked to the growth and stability of another protein called PLK1. This suggests that TSN might halt cancer progression by disrupting this harmful interplay.
In our studies, we also employed various techniques, including flow cytometry and western blotting, to confirm our findings. At the end of our research, we confirmed that TSN not only effectively slows down tumor growth but does so by targeting the USP39/PLK1 pathway. Altogether, these insights provide valuable information about how TSN could serve as a promising candidate in the battle against prostate cancer.
8.3
Prostate cancer protection
Most Useful Review
Rich in iron and protein, I consume a handful of pumpkin seeds between meals. They also contain zinc, selenium, kelp, and copper, which I believe help protect my prostate cancer.
Allergies details
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.4
8
Recombinant proteins for allergy diagnosis
Pattern of sensitization to yellow jacket venom and expression of recombinant antigen 5 (Ves v 5) from yellow jacket venom.
Most Relevant Research
We explored the potential of recombinant phospholipase A5, also known as Ves v 5, to improve the diagnosis of yellow jacket venom allergies. Our study involved seven individuals, including those who had allergic reactions and those who did not. By isolating serum samples from these participants, we assessed their reactions to both bee venom and the recombinant allergens.
The production of Ves v 5 was successfully carried out in Escherichia coli, leading to the creation of soluble proteins that we then purified. We performed various tests to evaluate these proteins' functionality. This included assessing their biochemical characteristics and how well they interacted with the immune system.
Our findings highlighted the significant role of Ves v 5 in allergic reactions to hymenoptera venoms. The results suggest that recombinant proteins can be a promising alternative for diagnosing these allergies, moving away from traditional methods that rely on whole venom extracts. Ultimately, allergen-specific therapies could provide more effective and tailored treatment options for those prone to these allergies.
The production of Ves v 5 was successfully carried out in Escherichia coli, leading to the creation of soluble proteins that we then purified. We performed various tests to evaluate these proteins' functionality. This included assessing their biochemical characteristics and how well they interacted with the immune system.
Our findings highlighted the significant role of Ves v 5 in allergic reactions to hymenoptera venoms. The results suggest that recombinant proteins can be a promising alternative for diagnosing these allergies, moving away from traditional methods that rely on whole venom extracts. Ultimately, allergen-specific therapies could provide more effective and tailored treatment options for those prone to these allergies.
9.5
Effective for allergies
Most Useful Review
Mumtaz The quality is excellent, and the ingredients do not cause any allergies; its taste is very pleasant. I use it daily, and the size is excellent. The package lasts for two months and is beneficial for increasing iron. I find it useful for those on a diet or exercising, and I use it twice with a protein recipe and refreshing mix. Thank you.
Diarrhea details
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.3
USERS' SCORE
Moderately Good
Based on 4 Reviews
7
9
P23-specific IgY reduces diarrhea
P23-Specific IgY Significantly Reduces Diarrhea and Oocyst Shedding in Calves Experimentally Infected with .
Most Relevant Research
We explored the impact of p23-specific IgY antibodies on diarrhea caused by a zoonotic enteroparasite in newborn calves. This research aimed to see if these antibodies could effectively reduce the duration and severity of diarrhea, which is a significant issue in dairy and beef farming.
In our study, we used eight newborn calves and divided them into two groups. Four calves received a treatment containing specific IgY from immunized hens, while the other four had regular milk. After orally infecting all calves with a significant number of oocysts, we carefully monitored their health for 21 days.
Our findings revealed that calves treated with the p23-specific IgY had a remarkable reduction in the duration of diarrhea—from 7.5 days to just 3.5 days. They also showed a significant decrease in the duration of oocyst shedding. Although we observed some delays in the onset and severity of diarrhea, these changes were not statistically significant.
Overall, this study indicates that p23-specific IgY antibodies present a promising option for managing neonatal diarrhea in calves. This treatment could offer a non-invasive method to improve calf health and reduce economic losses for farmers.
In our study, we used eight newborn calves and divided them into two groups. Four calves received a treatment containing specific IgY from immunized hens, while the other four had regular milk. After orally infecting all calves with a significant number of oocysts, we carefully monitored their health for 21 days.
Our findings revealed that calves treated with the p23-specific IgY had a remarkable reduction in the duration of diarrhea—from 7.5 days to just 3.5 days. They also showed a significant decrease in the duration of oocyst shedding. Although we observed some delays in the onset and severity of diarrhea, these changes were not statistically significant.
Overall, this study indicates that p23-specific IgY antibodies present a promising option for managing neonatal diarrhea in calves. This treatment could offer a non-invasive method to improve calf health and reduce economic losses for farmers.
2.5
Unsafe for infants
Most Useful Review
Pumpkin seeds are beneficial for bone health due to their magnesium and calcium content. The taste and quality are superb, better than in shops. However, they are not safe for infants, as they can lead to pain, vomiting, and diarrhoea.
