' 
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B-6 (as Pyridoxine Hydrochloride)
10 mg
588%
Calcium (as Calcium Carbonate)
60 mg
5%
Melatonin
5 mg
*
The product is found useful for the following medical conditions
Allergies
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Excellent
Based on 2 Reviews
9.5
9.5
No allergies noted
Most Useful Review
I followed the dosage closely and found this product to be of excellent quality. The ingredients are carefully selected and did not trigger any allergies. The capsules are medium-sized and have a neutral taste. Delivery was prompt and without damage. I've noticed improvements in my metabolism and intestinal function within a week. My nervous system feels more stable, leading to less anxiety. The product's effectiveness is clear to me.
Fibromyalgia
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Excellent
Based on 2 Reviews
9.2
9.5
Improved sleep quality
Most Useful Review
This has been a lifesaver for me! I have chronic pain from osteoarthritis and fibromyalgia, which makes sleeping difficult. With a weak heart, being overtired leaves me feeling unwell. I previously received melatonin from a compounding pharmacist, but it was costly. I’m delighted to find it available here. It works well, allowing me eight hours of restful sleep, hence improving my health. I will try 3mg next and continue ordering melatonin, as it has greatly enhanced my quality of sleep and life.
Prostate Cancer
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Excellent
Based on 2 Reviews
9.2
9.5
Improved sleep quality
Most Useful Review
This helps me sleep through the night! My enlarged prostate causes frequent awakenings, but this allows me to remain asleep the entire night.
Stroke
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Excellent
Based on 2 Reviews
9.2
9.5
Improved wellbeing
Most Useful Review
After purchasing this for my mother post-stroke, she feels much better. I now sleep soundly and fall asleep quickly, waking up cheerfully!
Breast Cancer
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Excellent
Based on 3 Reviews
9
9.5
Safe for sleep
Most Useful Review
I have taken melatonin every night for years and would never travel without it. Recommended by my doctor after a bout of breast cancer 20 years ago, I find it safe and non-addictive.
Depression
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Very Good
Based on 6 Reviews
8.9
9.5
Menopause relief
Most Useful Review
Melatonin saved me from insomnia caused by menopause. Despite being terrified of potential side effects, I tried it and found it effective. One hour before sleep, I feel drowsy and able to fall asleep easily after struggling for ages. Initially, I used it every two days, but after a month, I could sleep without it. It feels like a memory inside my body.
Gastritis
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Very Good
Based on 1 Reviews
8.8
8.8
Effective for gastritis
Most Useful Review
I used it confidently, even with acute gastritis, and found it safe. It didn't strain me, and when combined with sleeping pills, it proved to be very effective.
Heart Disease
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Very Good
Based on 1 Reviews
8.8
8.8
Improved sleep quality
Most Useful Review
This has been a lifesaver for me! I suffer from chronic pain due to osteoarthritis and fibromyalgia, which often makes sleeping difficult. With heart disease, sleepless nights really impact my ability to function. I previously had melatonin prepared by a pharmacist, which was costly. Finding it here has been a delight. It helps me achieve restful sleep for over eight hours, improving my health significantly. I plan to try 3mg next and will continue ordering melatonin, as it has greatly enhanced my sleep quality and life overall.
Chronic Fatigue Syndrome
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Very Good
Based on 16 Reviews
8.7
9.5
Effective sleep aid
Most Useful Review
Melatonin is a natural adaptogen that has worked wonderfully for me. One 3 mg tablet taken before bed helps me sleep deeply without side effects. I wake up refreshed, ready to take on the day. It's effective for managing chronic fatigue syndrome and I recommend it to everyone.
Insomnia
SCIENTIFIC SCORE
Most Likely Effective
Based on 13 Researches
8.2
USERS' SCORE
Very Good
Based on 92 Reviews
8.6
9
Melatonin delivery enhances sleep
Silk fibroin microneedles loaded with melatonin for circadian rhythm regulation.
Most Relevant Research
We developed a new way to deliver melatonin for those struggling with insomnia by creating microneedles made from silk fibroin. These tiny needles are designed to improve how the body absorbs melatonin, making it easier for people to get to sleep and stay asleep.
Our research shows that these microneedles can release melatonin steadily over a period of 11 hours. When we tested it on animals, we found that the microneedles maintained stable levels of drug in the bloodstream for up to 8 hours. This is promising news for individuals who may need help with their sleep cycles.
Additionally, the microneedles not only helped regulate sleep but also made a noticeable difference in anxiety levels in insomnia model rats. By improving the disrupted circadian rhythms, melatonin loaded into these microneedles could lead to significant therapeutic benefits.
We believe this innovative approach could enhance patient compliance and provide effective sleep aid for many in need. It’s an exciting development in the field of transdermal drug delivery for improving sleep quality and overcoming insomnia.
Our research shows that these microneedles can release melatonin steadily over a period of 11 hours. When we tested it on animals, we found that the microneedles maintained stable levels of drug in the bloodstream for up to 8 hours. This is promising news for individuals who may need help with their sleep cycles.
Additionally, the microneedles not only helped regulate sleep but also made a noticeable difference in anxiety levels in insomnia model rats. By improving the disrupted circadian rhythms, melatonin loaded into these microneedles could lead to significant therapeutic benefits.
We believe this innovative approach could enhance patient compliance and provide effective sleep aid for many in need. It’s an exciting development in the field of transdermal drug delivery for improving sleep quality and overcoming insomnia.
9.5
Drug-free sleep aid
Most Useful Review
Melatonin is a fantastic option for those experiencing occasional insomnia. It’s a drug-free sleep aid that aids relaxation and improves sleep quality. It helps restore the body's natural biorhythms for better stress resilience and positive emotions during the day. As a powerful antioxidant with no side effects or addiction risks, it’s an excellent choice for healthy sleep.
Cancer
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Very Good
Based on 8 Reviews
8.5
9.5
Safe for cancer recovery
Most Useful Review
I’ve been taking melatonin for years without fail, especially recommended after my breast cancer 20 years ago. It ensures I have a good night’s sleep and is safe without causing addiction.
Menopause
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Very Good
Based on 12 Reviews
8.5
8.8
Effective sleep aid
Most Useful Review
I was taking benzodiazepines for insomnia during menopause, but they didn’t work and left me dazed in the morning. After hearing positive feedback, I tried this and was astonished by its effectiveness. I felt drowsy within 20 minutes and slept through the night. I found it a bit strong, so I plan to cut the dosage next time. The size is small and tasteless, making it easy to take. I believe it offers great value for money.
Obesity
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Very Good
Based on 2 Reviews
8.5
8.8
Improved obesity management
Most Useful Review
This supplement has been a lifesaver for me. I originally used melatonin to combat jet lag, but now I take it daily for better sleep. Over the past decade, I've noticed various benefits, particularly in managing my obesity and improving my work performance. I believe the antioxidant properties of melatonin contribute to keeping me youthful. It's a supplement I cannot imagine living without, and I highly recommend trying it before resorting to sleep medications.
Anxiety
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
6.7
USERS' SCORE
Very Good
Based on 15 Reviews
8.4
9
Melatonin reduces anxiety from glyphosate
Melatonin attenuates affective disorders and cognitive deficits induced by perinatal exposure to a glyphosate-based herbicide via antioxidant pathway in adult male and female rats.
Most Relevant Research
Our research examined the effects of melatonin on anxiety and memory problems caused by exposure to glyphosate-based herbicides (GBH). We started with pregnant Wistar rats that were subjected to GBH during gestation and lactation. After weaning, the offspring were treated with melatonin to see if it could help mitigate the negative effects they experienced due to their early exposure.
We observed that exposure to GBH led to increased anxiety and depression-like behaviors in the rats. Additionally, it appeared to impair their memory function. In looking at oxidative stress markers in the brain regions associated with emotion and cognition, we found indications of increased stress—especially pronounced in the female offspring.
However, the inclusion of melatonin significantly reduced these anxiety levels and improved cognitive deficits. Interestingly, the benefits were notably greater in female rats compared to males, suggesting a potential sex-dependent response to melatonin treatment.
We observed that exposure to GBH led to increased anxiety and depression-like behaviors in the rats. Additionally, it appeared to impair their memory function. In looking at oxidative stress markers in the brain regions associated with emotion and cognition, we found indications of increased stress—especially pronounced in the female offspring.
However, the inclusion of melatonin significantly reduced these anxiety levels and improved cognitive deficits. Interestingly, the benefits were notably greater in female rats compared to males, suggesting a potential sex-dependent response to melatonin treatment.
9.5
Peaceful sleep
Most Useful Review
I enjoyed taking it an hour before bed. It helped me sleep peacefully and comfortably. Occasionally, I took two pills without experiencing anxiety or addiction.
Tinnitus
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Very Good
Based on 2 Reviews
8.4
8.8
Improved sleep quality
Most Useful Review
My husband has always struggled with tinnitus, making it hard for him to relax and sleep. This product has helped him achieve a sweet sleep, and he wakes up in good spirits and mood. No side effects were noted after taking it.
Sleep Apnea
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Very Good
Based on 139 Reviews
8.3
9.5
Improves sleep quality
Most Useful Review
Excellent! It aids in improving sleep and helps me fall asleep faster.
High Cholesterol
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Very Good
Based on 2 Reviews
8.2
9.5
Reduces cholesterol levels
Most Useful Review
Melatonin does more than control sleep; it acts as an antioxidant, reducing oxidative damage while sleeping. It enhances enzyme functions related to active oxygen elimination and lipid metabolism, which is vital for women in their 40s and 50s facing lipid metabolism issues. Additionally, it suppresses insulin secretion, and irregular melatonin secretion in shift workers is linked to high cholesterol and obesity risks.
Autoimmune Disorder
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Very Good
Based on 6 Reviews
7.4
9.5
Effective treatment
Most Useful Review
I’m currently in the hospital for a sleep disorder (insomnia). My doctor recommended melatonin, which makes me feel drowsy about an hour after taking it. The effect is remarkable!
Reflux
SCIENTIFIC SCORE
Most Likely Effective
Based on 16 Researches
7.7
USERS' SCORE
Very Good
Based on 2 Reviews
7.2
9
Melatonin reduces reflux esophagitis damage
Melatonin protects against experimental reflux esophagitis.
Most Relevant Research
We explored how melatonin can protect the esophagus from reflux esophagitis (RE), a condition where stomach contents flow back into the esophagus, often causing painful inflammation. In our research with rats, we found that melatonin pretreatment resulted in significantly fewer bleeding lesions and lower levels of harmful lipid peroxidation typically caused by RE.
Additionally, melatonin helped replenish important antioxidants in the esophagus, suggesting its potential to neutralize free radicals that contribute to tissue damage. As we delved into the immune response, we observed that melatonin decreased the levels of certain pro-inflammatory cytokines, like TNF-alpha and IL-6, while keeping the levels of the anti-inflammatory cytokine IL-10 steady.
Interestingly, when we tested a melatonin receptor blocker, luzindole, we discovered that this approach did not hinder melatonin's protective effects. This indicates that melatonin works its magic in a receptor-independent way as well, not just through its antioxidant properties but also by modulating inflammation. Overall, we found that melatonin could be a beneficial ally for those suffering from reflux esophagitis, providing insights for future treatment strategies.
Additionally, melatonin helped replenish important antioxidants in the esophagus, suggesting its potential to neutralize free radicals that contribute to tissue damage. As we delved into the immune response, we observed that melatonin decreased the levels of certain pro-inflammatory cytokines, like TNF-alpha and IL-6, while keeping the levels of the anti-inflammatory cytokine IL-10 steady.
Interestingly, when we tested a melatonin receptor blocker, luzindole, we discovered that this approach did not hinder melatonin's protective effects. This indicates that melatonin works its magic in a receptor-independent way as well, not just through its antioxidant properties but also by modulating inflammation. Overall, we found that melatonin could be a beneficial ally for those suffering from reflux esophagitis, providing insights for future treatment strategies.
8.8
Improvement noted
Most Useful Review
I’m a fan of Natrol products and normally take 1 mg of melatonin for sleep. However, I read that 5 mg for 30 days can help with reflux, and I experienced significant improvement. I'd definitely recommend it, but I suggest researching it first.
Migraine
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
6.6
USERS' SCORE
Very Good
Based on 4 Reviews
7.1
5
Melatonin's mixed effects on migraine
Melatonin for Acute Treatment of Migraine in Children and Adolescents: A Pilot Randomized Trial.
Most Relevant Research
We explored the potential of melatonin as an acute treatment for migraines in children and adolescents aged 4 to 17 years. Our study involved a randomized trial where participants were given either a high or a low dose of melatonin to see which worked better to relieve migraine pain.
The results revealed that both dosages led to some level of pain reduction, though the difference wasn't significant. The high-dose group saw an average pain reduction of 2.7 cm on a scale, while the low-dose group reported a 2.3 cm reduction, a difference that wasn't statistically meaningful.
We also observed a fairly high dropout rate from the study, which could impact our findings on effectiveness. Interestingly, we found that taking a higher dose of melatonin and napping afterward seemed to correlate with better migraine relief. Overall, while melatonin shows promise as a treatment, we must continue our investigation to establish clearer benefits.
The results revealed that both dosages led to some level of pain reduction, though the difference wasn't significant. The high-dose group saw an average pain reduction of 2.7 cm on a scale, while the low-dose group reported a 2.3 cm reduction, a difference that wasn't statistically meaningful.
We also observed a fairly high dropout rate from the study, which could impact our findings on effectiveness. Interestingly, we found that taking a higher dose of melatonin and napping afterward seemed to correlate with better migraine relief. Overall, while melatonin shows promise as a treatment, we must continue our investigation to establish clearer benefits.
9.5
Effective treatment
Most Useful Review
This product is great; it significantly helps with my migraines and fibromyalgia.
Bone Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Medium or Average
Based on 4 Reviews
6.5
9.5
Relief from pain
Most Useful Review
This product has been a lifesaver for me! Due to chronic pain from osteoarthritis and fibromyalgia, sleeping is a challenge. A night without sleep exacerbates my bone pain. I was thrilled to find melatonin here; it offers me restful sleep for over eight hours, significantly enhancing my health. I plan to try a higher dose next.
Dizziness
SCIENTIFIC SCORE
Most Likely Effective
Based on 1 Researches
7
USERS' SCORE
Medium or Average
Based on 19 Reviews
6
7
Melatonin's impact on dizziness
Addressing Sleep Disorders in Psychiatry: Comparing the Use of Melatonin, Trazodone, and Doxepin.
Most Relevant Research
We assessed how melatonin affects dizziness in patients dealing with sleep disturbances tied to psychiatric conditions. In a study with 175 participants, we found that melatonin was slightly less effective than trazodone and doxepin in improving overall sleep quality. However, it stood out for having a low incidence of adverse effects. Specifically, the rates of dizziness associated with melatonin use were measured, showing a relatively low occurrence.
While it did not provide the most substantial improvement in sleep quality, melatonin showed promise in enhancing tolerability among users. Only 10% of participants reported dizziness, which indicates that melatonin might be a safer option for those worried about side effects from more potent medications. By choosing melatonin, patients can potentially find a balance between managing sleep disturbances while minimizing unwanted symptoms like dizziness.
Overall, we observed that for individuals focused on avoiding adverse effects, melatonin serves as a viable alternative within this treatment landscape. Its effectiveness in curbing dizziness contributes to discussions on how best to treat sleep disorders in psychiatric patients without compromising their comfort.
While it did not provide the most substantial improvement in sleep quality, melatonin showed promise in enhancing tolerability among users. Only 10% of participants reported dizziness, which indicates that melatonin might be a safer option for those worried about side effects from more potent medications. By choosing melatonin, patients can potentially find a balance between managing sleep disturbances while minimizing unwanted symptoms like dizziness.
Overall, we observed that for individuals focused on avoiding adverse effects, melatonin serves as a viable alternative within this treatment landscape. Its effectiveness in curbing dizziness contributes to discussions on how best to treat sleep disorders in psychiatric patients without compromising their comfort.
8.8
Helps with dizziness
Most Useful Review
I can sleep! Initially, I was sceptical, but it certainly helps me sleep better. If I take a higher dosage, I feel dizzy.
