Natrol Melatonin Fast Dissolve Tablets

This has been a lifesaver for me! I have chronic pain from osteoarthritis and fibromyalgia, which makes sleeping difficult. With a weak heart, being overtired leaves me feeling unwell. I previously received melatonin from a compounding pharmacist, but it was costly. I’m delighted to find it available here. It works well, allowing me eight hours of restful sleep, hence improving my health. I will try 3mg next and continue ordering melatonin, as it has greatly enhanced my quality of sleep and life.

Flu details

Melatonin mitigates flu-induced lung injury

Based on 3 Researches

Huo C, Tang Y, Li X, Han D, Gu Q, et al. Melatonin alleviates lung injury in H1N1-infected mice by mast cell inactivation and cytokine storm suppression. PLoS Pathog. 2023;19:e1011406. doi:10.1371/journal.ppat.1011406

We explored the potential of melatonin as a treatment for H1N1 flu infection. In our study, we found that melatonin, a powerful antioxidant and anti-inflammatory compound, could significantly protect against the flu in both laboratory tests and in living mice.

Our findings showed that higher local levels of melatonin in the nose and lungs correlated with lower death rates from the virus. In fact, melatonin-deficient mice had much higher mortality rates, which were notably reduced when treated with melatonin.

We discovered that melatonin primarily works by targeting mast cells, which are important players in the body’s immune response. By suppressing the activation of these cells after H1N1 infection, melatonin helps control the release of inflammatory proteins, leading to less damage in lung tissue. This mechanism highlights how melatonin treatment can prevent serious lung injury caused by the virus, opening up new avenues for post-flu recovery strategies.

Easier to sleep

Most Useful Review

3 people found this helpful

I can fall asleep better. I've always struggled with sleep, especially around the middle of the week. After starting melanitone, I sleep within about 15 minutes, and I’m no longer restless during the day. It’s a very good supplement.

We focused on the effects of oral melatonin on anxiety and pain in children during the stressful process of venipuncture. In a double-blind, randomized controlled trial, we found that administering 0.5 mg/kg of melatonin 30 minutes before the procedure significantly reduced both pain and anxiety levels compared to a placebo.

The results showed that only 18.8% of the kids receiving melatonin reported pain, while 78.2% in the placebo group did. Furthermore, anxiety affected 44.6% of the melatonin group compared to 94.1% of those in the control group.

While melatonin appeared to improve experiences during venipuncture, its impact on the success rate was not statistically significant.

Peaceful sleep

Most Useful Review

3 people found this helpful

I enjoyed taking it an hour before bed. It helped me sleep peacefully and comfortably. Occasionally, I took two pills without experiencing anxiety or addiction.

Chronic Fatigue Syndrome details

Melatonin ineffective for CFS symptoms

Questionable

Based on 7 Researches

Williams G, Waterhouse J, Mugarza J, Minors D, Hayden K. Therapy of circadian rhythm disorders in chronic fatigue syndrome: no symptomatic improvement with melatonin or phototherapy. Eur J Clin Invest. 2002;32:831.

We evaluated whether melatonin and bright-light phototherapy could help alleviate symptoms of chronic fatigue syndrome (CFS). In a controlled study with thirty participants, we assessed the effectiveness of these treatments by measuring various symptoms over several weeks.

Unfortunately, we found that neither melatonin nor phototherapy led to significant improvements in the patients’ symptoms or overall health. Our findings suggest that these treatments shouldn't be promoted for CFS unless proven beneficial.

Effective sleep aid

Most Useful Review

5 people found this helpful

Melatonin is a natural adaptogen that has worked wonderfully for me. One 3 mg tablet taken before bed helps me sleep deeply without side effects. I wake up refreshed, ready to take on the day. It's effective for managing chronic fatigue syndrome and I recommend it to everyone.

Cancer details

Safe for cancer recovery

I’ve been taking melatonin for years without fail, especially recommended after my breast cancer 20 years ago. It ensures I have a good night’s sleep and is safe without causing addiction.

Menopause details

Melatonin aids perimenopausal relief

Based on 10 Researches

Zhang J, Jiang B. Influence of Melatonin Treatment on Emotion, Sleep, and Life Quality in Perimenopausal Women: A Clinical Study. J Healthc Eng. 2023;2023:2198804. doi:10.1155/2023/2198804

We evaluated the effects of melatonin treatment on emotion, sleep, and quality of life in 100 healthy perimenopausal women. Participants were divided into two groups: one receiving melatonin and the other a placebo over three cycles.

After analyzing various hormonal levels and using questionnaires to assess perimenopausal symptoms, sleep quality, anxiety, and mood, we found that melatonin significantly alleviated climacteric symptoms.

Participants reported improved sleep, enhanced mood, and a better overall quality of life without serious side effects.

7.5

Effective sleep aid

Most Useful Review

10 people found this helpful

I was taking benzodiazepines for insomnia during menopause, but they didn’t work and left me dazed in the morning. After hearing positive feedback, I tried this and was astonished by its effectiveness. I felt drowsy within 20 minutes and slept through the night. I found it a bit strong, so I plan to cut the dosage next time. The size is small and tasteless, making it easy to take. I believe it offers great value for money.

Reflux details

Melatonin reduces reflux esophagitis damage

Based on 16 Researches

Lahiri S, Singh P, Singh S, Rasheed N, Palit G, et al. Melatonin protects against experimental reflux esophagitis. J Pineal Res. 2009;46:207. doi:10.1111/j.1600-079X.2008.00650.x

We explored how melatonin can protect the esophagus from reflux esophagitis (RE), a condition where stomach contents flow back into the esophagus, often causing painful inflammation. In our research with rats, we found that melatonin pretreatment resulted in significantly fewer bleeding lesions and lower levels of harmful lipid peroxidation typically caused by RE.

Additionally, melatonin helped replenish important antioxidants in the esophagus, suggesting its potential to neutralize free radicals that contribute to tissue damage. As we delved into the immune response, we observed that melatonin decreased the levels of certain pro-inflammatory cytokines, like TNF-alpha and IL-6, while keeping the levels of the anti-inflammatory cytokine IL-10 steady.

Interestingly, when we tested a melatonin receptor blocker, luzindole, we discovered that this approach did not hinder melatonin's protective effects. This indicates that melatonin works its magic in a receptor-independent way as well, not just through its antioxidant properties but also by modulating inflammation. Overall, we found that melatonin could be a beneficial ally for those suffering from reflux esophagitis, providing insights for future treatment strategies.

7.5

Improvement noted

Most Useful Review

I’m a fan of Natrol products and normally take 1 mg of melatonin for sleep. However, I read that 5 mg for 30 days can help with reflux, and I experienced significant improvement. I'd definitely recommend it, but I suggest researching it first.

Autoimmune Disorder details

Melatonin improves MS-related symptoms

Based on 16 Researches

Jallouli S, Jallouli D, Damak M, Sakka S, Ghroubi S, et al. 12-week melatonin intake attenuates cardiac autonomic dysfunction and oxidative stress in multiple sclerosis patients: a randomized controlled trial. Metab Brain Dis. 2024;40:52. doi:10.1007/s11011-024-01428-2

We explored the impact of melatonin on patients with multiple sclerosis (MS), aiming to improve heart function and sleep. In a randomized controlled trial, participants received either melatonin or a placebo for 12 weeks.

We observed significant improvements in heart rate variability and markers of oxidative stress, suggesting that melatonin could enhance heart health and lower stress in MS patients. Additionally, sleep quality and quantity also improved with melatonin use.

This study indicates that melatonin might be a beneficial treatment option for managing cardiac issues and sleep disturbances in MS.

Effective treatment

Most Useful Review

1 people found this helpful

I’m currently in the hospital for a sleep disorder (insomnia). My doctor recommended melatonin, which makes me feel drowsy about an hour after taking it. The effect is remarkable!

Bone Pain details

This product has been a lifesaver for me! Due to chronic pain from osteoarthritis and fibromyalgia, sleeping is a challenge. A night without sleep exacerbates my bone pain. I was thrilled to find melatonin here; it offers me restful sleep for over eight hours, significantly enhancing my health. I plan to try a higher dose next.

Insomnia details

Li X, Chen Y, Shao H, Yan Z, Wang Y, et al. Silk fibroin microneedles loaded with melatonin for circadian rhythm regulation. Int J Biol Macromol. 2025;301:140500. doi:10.1016/j.ijbiomac.2025.140500

Based on 23 Researches

Melatonin delivery enhances sleep

We developed a new way to deliver melatonin for those struggling with insomnia by creating microneedles made from silk fibroin. These tiny needles are designed to improve how the body absorbs melatonin, making it easier for people to get to sleep and stay asleep.

Our research shows that these microneedles can release melatonin steadily over a period of 11 hours. When we tested it on animals, we found that the microneedles maintained stable levels of drug in the bloodstream for up to 8 hours. This is promising news for individuals who may need help with their sleep cycles.

Additionally, the microneedles not only helped regulate sleep but also made a noticeable difference in anxiety levels in insomnia model rats. By improving the disrupted circadian rhythms, melatonin loaded into these microneedles could lead to significant therapeutic benefits.

We believe this innovative approach could enhance patient compliance and provide effective sleep aid for many in need. It’s an exciting development in the field of transdermal drug delivery for improving sleep quality and overcoming insomnia.

Drug-free sleep aid

Most Useful Review

211 people found this helpful

Melatonin is a fantastic option for those experiencing occasional insomnia. It’s a drug-free sleep aid that aids relaxation and improves sleep quality. It helps restore the body's natural biorhythms for better stress resilience and positive emotions during the day. As a powerful antioxidant with no side effects or addiction risks, it’s an excellent choice for healthy sleep.

Migraine details

Melatonin may reduce migraine frequency

Questionable

Based on 20 Researches

Tseng PT, Yang CP, Su KP, Chen TY, Wu YC, et al. The association between melatonin and episodic migraine: A pilot network meta-analysis of randomized controlled trials to compare the prophylactic effects with exogenous melatonin supplementation and pharmacotherapy. J Pineal Res. 2020;69:e12663. doi:10.1111/jpi.12663

We explored whether melatonin can effectively prevent migraines by analyzing data from 25 randomized controlled trials, involving nearly 4,500 participants.

The findings suggested that taking 3 mg of oral melatonin at bedtime could reduce the frequency of migraine days and had a favorable response rate compared to a placebo.

Notably, melatonin was regarded as one of the better options when considering overall effectiveness and tolerability. These results highlight melatonin's potential as a helpful preventive treatment for those struggling with episodic migraines.

Effective treatment

Most Useful Review

This product is great; it significantly helps with my migraines and fibromyalgia.

Sleep Apnea details

Melatonin improves sleep apnea outcomes

Based on 4 Researches

Motlaq TM, Rahimi B, Amini S. Effect of melatonin on insomnia and daytime sleepiness, in patients with obstructive sleep apnea and insomnia (COMISA): A randomized double-blinded placebo-controlled trial. J Pharm Health Care Sci. 2024;10:25. doi:10.1186/s40780-024-00347-9

We investigated how melatonin affects patients with obstructive sleep apnea and insomnia. In a double-blind trial, thirty patients received either 10 mg of melatonin or a placebo for a month.

The results were striking; those taking melatonin reported better sleep quality, less daytime sleepiness, and greater adherence to their PAP devices. Improvements were noted across several assessments: the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Epworth Sleepiness Scale, and Functional Outcomes of Sleep Questionnaire showed significant gains for the melatonin group.

Thus, melatonin appears to be a promising option to enhance sleep quality and treatment compliance in this challenging patient group.

Improves sleep quality

Most Useful Review

30 people found this helpful

Excellent! It aids in improving sleep and helps me fall asleep faster.

Chest Pain details

Since starting this melatonin, my sleep quality has improved greatly. I used to wake up frequently during the night, which aggravated my chest pain in the mornings. Now, I sleep soundly until morning and the pain has eased considerably, allowing me to move with ease in the mornings. I'm thrilled with this development, and I plan to continue using it.

Leg Cramps details

Helps me relax and alleviates my restless leg syndrome without leaving me drowsy, unlike prescribed medication. I highly recommend it.

Knee Pain details

Improved sleep quality

I regularly purchase this melatonin as it has notably enhanced my sleep quality. While it hasn't fully alleviated my knee pain upon waking, my overall sleep has improved, making waking up in the morning slightly easier. I've been using this since my teenage years, especially for issues related to my orthostatic disorder. I'm relieved that it helps me sleep better and facilitates easier waking, which I truly appreciate.

Heart Attack details

Improved sleep quality

Improved sleep and life quality. It's been a lifesaver! I struggle with chronic pain due to osteoarthritis and fibromyalgia, making sleep difficult. With a weak heart, being overtired affects my health severely. Previously, I had melatonin made by a pharmacist, which was costly. Finding it here has been delightful; it gives me over 8 hours of restful sleep and enhances my well-being. I plan to try 3mg soon. Melatonin significantly improved my sleep and, consequently, my life quality.

Back Pain details

Quality sleep improvement

I regularly buy this for my son, who has orthostatic disorder. He struggles to sleep at night and has difficulty waking in the morning, often feeling ill. A pediatrician recommended this to him when he was 15, and while waking up hasn't improved, it has helped his sleep quality. He still uses it as he can now fall asleep more easily. I hope other children with similar conditions find relief too.

Nausea details