Natrol Melatonin Fast Dissolve Tablets

Melatonin reduces pediatric anxiety, pain

Based on 7 Researches

Rahafard S, Akbari Jokar Z, Hosseini SA, Alaee E. The impact of oral melatonin on pain and anxiety reduction during venipuncture in pediatric patients: a double-blind randomized clinical trial. Ann Med Surg (Lond). 2024;86:5811. doi:10.1097/MS9.0000000000002163

We focused on the effects of oral melatonin on anxiety and pain in children during the stressful process of venipuncture. In a double-blind, randomized controlled trial, we found that administering 0.5 mg/kg of melatonin 30 minutes before the procedure significantly reduced both pain and anxiety levels compared to a placebo.

The results showed that only 18.8% of the kids receiving melatonin reported pain, while 78.2% in the placebo group did. Furthermore, anxiety affected 44.6% of the melatonin group compared to 94.1% of those in the control group.

While melatonin appeared to improve experiences during venipuncture, its impact on the success rate was not statistically significant.

Deep, restful sleep

Most Useful Review

6 people found this helpful

This drug was my salvation. I always suffered from anxiety, which would keep me awake for 2-3 hours. I often woke up in the middle of the night with a racing heartbeat. Taking one pill before bed works wonders; after about 20-25 minutes, I fall asleep peacefully. The sleep is very deep and enjoyable, with calm and colourful dreams. For the first time, I sleep 7-8 hours without disturbance and wake up feeling rested and ready to start my day. My overall condition has improved without any lethargy or weakness.

Atrial Septal Defect details

This product has genuinely been transformative for my two sons with atrial septal defect and ADHD!

Depression details

Improved sleep quality

Since taking Melatonin 3mg tablets, my sleep has significantly improved. I have struggled with depression and had trouble sleeping for ages. Unlike other products I've tried, there’s no groggy feeling in the morning. I highly recommend them.

High Cholesterol details

Better sleep experience

1 people found this helpful

Natrol Melatonin has significantly improved my sleep. Previously, I struggled with insomnia and often found it difficult to sleep, but since using this product, I've been falling asleep quicker and waking up refreshed. The 3mg dosage suits me perfectly, and I haven't encountered any side effects. If you have challenges sleeping or adjusting your sleep schedule, I highly recommend trying this product!

Cancer details

Confidence in treatment

I believe this is more effective than NOW's melatonin. Recently, I've been drinking nearly 10ml, so I'm taking 3 tablets of this product. I had insomnia, but I am thankful that I can now sleep without overthinking. Melatonin has antioxidant properties and appears suitable for cancer prevention and treatment, which makes me take it with confidence.

Heart Attack details

3 people found this helpful

When I had worries that kept me awake for an hour, I tried this product. About 20 minutes after taking it, I experienced an intense sleep attack. The effect is remarkable. Even on days I missed a dose, I fell asleep better, possibly thanks to the vitamin B included.

Menopause details

Melatonin aids perimenopausal relief

Based on 10 Researches

Zhang J, Jiang B. Influence of Melatonin Treatment on Emotion, Sleep, and Life Quality in Perimenopausal Women: A Clinical Study. J Healthc Eng. 2023;2023:2198804. doi:10.1155/2023/2198804

We evaluated the effects of melatonin treatment on emotion, sleep, and quality of life in 100 healthy perimenopausal women. Participants were divided into two groups: one receiving melatonin and the other a placebo over three cycles.

After analyzing various hormonal levels and using questionnaires to assess perimenopausal symptoms, sleep quality, anxiety, and mood, we found that melatonin significantly alleviated climacteric symptoms.

Participants reported improved sleep, enhanced mood, and a better overall quality of life without serious side effects.

Sleep improvement

Most Useful Review

4 people found this helpful

After ten years of insomnia resulting from menopause, I found melatonin to be the most effective solution compared to GABA and tryptophan. For the first time in ages, I experienced actual sleepiness and could return to sleep if I woke during the night. Initially taking vitamin D prior to melatonin may have helped.

Rash details

Improved sleep quality

7 people found this helpful

The product truly works. I bought it knowing its benefits, not really focusing on any downsides, as I haven’t encountered any. With this product, I enjoy a deep sleep and notice my rash is improved by morning. I wake up early, around 5 am, and aim to stay awake until 10 pm. I engage in morning workouts from 7 am before heading to work. Melatonin enables me to get sufficient rest and wake up refreshed. Just ensure that after taking a pill before bed, you switch off all lights and the TV. The hormone functions best in complete darkness. I highly recommend trying it; you won’t regret it.

Autoimmune Disorder details

Melatonin improves MS-related symptoms

Based on 16 Researches

Jallouli S, Jallouli D, Damak M, Sakka S, Ghroubi S, et al. 12-week melatonin intake attenuates cardiac autonomic dysfunction and oxidative stress in multiple sclerosis patients: a randomized controlled trial. Metab Brain Dis. 2024;40:52. doi:10.1007/s11011-024-01428-2

We explored the impact of melatonin on patients with multiple sclerosis (MS), aiming to improve heart function and sleep. In a randomized controlled trial, participants received either melatonin or a placebo for 12 weeks.

We observed significant improvements in heart rate variability and markers of oxidative stress, suggesting that melatonin could enhance heart health and lower stress in MS patients. Additionally, sleep quality and quantity also improved with melatonin use.

This study indicates that melatonin might be a beneficial treatment option for managing cardiac issues and sleep disturbances in MS.

Effective treatment

Most Useful Review

2 people found this helpful

Really helps to establish a sleep routine and is non-addictive! I had a terrible schedule for years, only sleeping in the morning and working late at night. My body was exhausted, leading to hair loss and nodular alopecia, worsened by breastfeeding. After taking melatonin, I fell asleep quickly and adjusted my routine. My bald patches healed, and my hair stopped falling out. Occasionally, I stray from routine, but melatonin helps me return to normal.

Chronic Fatigue Syndrome details

Melatonin ineffective for CFS symptoms

Questionable

Based on 7 Researches

Williams G, Waterhouse J, Mugarza J, Minors D, Hayden K. Therapy of circadian rhythm disorders in chronic fatigue syndrome: no symptomatic improvement with melatonin or phototherapy. Eur J Clin Invest. 2002;32:831.

We evaluated whether melatonin and bright-light phototherapy could help alleviate symptoms of chronic fatigue syndrome (CFS). In a controlled study with thirty participants, we assessed the effectiveness of these treatments by measuring various symptoms over several weeks.

Unfortunately, we found that neither melatonin nor phototherapy led to significant improvements in the patients’ symptoms or overall health. Our findings suggest that these treatments shouldn't be promoted for CFS unless proven beneficial.

Combatting fatigue effectively

Most Useful Review

An effective product for insomnia, it works quickly and has a lasting impact. It doesn't lead to headaches upon waking, and I can stop using it easily without becoming dependent.

Nausea details

Melatonin linked to nausea management

Based on 2 Researches

Söderquist F, Janson ET, Rasmusson AJ, Ali A, Stridsberg M, et al. Melatonin Immunoreactivity in Malignant Small Intestinal Neuroendocrine Tumours. PLoS One. 2016;11:e0164354. doi:10.1371/journal.pone.0164354

We explored how melatonin could affect nausea in patients with small intestinal neuroendocrine tumors (SI-NETs). Our research involved studying tumor tissue from 26 patients, examining their primary tumors alongside metastases for the presence of melatonin and its receptors.

Interestingly, we found that higher melatonin levels in the body were linked to reported experiences of nausea. Specifically, patients with higher plasma melatonin levels at both time points indicated more frequent nausea occurrences. This underscores the potential role of melatonin in influencing nausea symptoms.

However, it's notable that in those cases where the disease was stable or improving, plasma levels of melatonin dropped after treatment, suggesting a complicated relationship between melatonin levels and treatment responses. These findings provide some valuable insights into the endocrine roles of melatonin in SI-NETs and signal a need for future studies to further dissect these relationships.

No nausea reported

Most Useful Review

The quality of this company is excellent, and the quantity in the box is appropriate. I recommend trying it for its effectiveness while ensuring you read the description. Importantly, it does not cause nausea.

Insomnia details

Li X, Chen Y, Shao H, Yan Z, Wang Y, et al. Silk fibroin microneedles loaded with melatonin for circadian rhythm regulation. Int J Biol Macromol. 2025;301:140500. doi:10.1016/j.ijbiomac.2025.140500

Based on 23 Researches

Melatonin delivery enhances sleep

We developed a new way to deliver melatonin for those struggling with insomnia by creating microneedles made from silk fibroin. These tiny needles are designed to improve how the body absorbs melatonin, making it easier for people to get to sleep and stay asleep.

Our research shows that these microneedles can release melatonin steadily over a period of 11 hours. When we tested it on animals, we found that the microneedles maintained stable levels of drug in the bloodstream for up to 8 hours. This is promising news for individuals who may need help with their sleep cycles.

Additionally, the microneedles not only helped regulate sleep but also made a noticeable difference in anxiety levels in insomnia model rats. By improving the disrupted circadian rhythms, melatonin loaded into these microneedles could lead to significant therapeutic benefits.

We believe this innovative approach could enhance patient compliance and provide effective sleep aid for many in need. It’s an exciting development in the field of transdermal drug delivery for improving sleep quality and overcoming insomnia.

Improved sleep quality

Most Useful Review

40 people found this helpful

Working well. This supplement truly aids my sleep. After struggling with insomnia, I now wake up feeling refreshed and cheerful. Before taking melatonin, I had difficulty sleeping and waking up. I no longer need an alarm clock. I recommend GABA for anyone facing similar insomnia issues.

Dizziness details

Melatonin's impact on dizziness

Mamoon B, Nawaz A, Khattak MI, Amir F, Akbar A, et al. Addressing Sleep Disorders in Psychiatry: Comparing the Use of Melatonin, Trazodone, and Doxepin. Cureus. 2024;16:e76507. doi:10.7759/cureus.76507

We assessed how melatonin affects dizziness in patients dealing with sleep disturbances tied to psychiatric conditions. In a study with 175 participants, we found that melatonin was slightly less effective than trazodone and doxepin in improving overall sleep quality. However, it stood out for having a low incidence of adverse effects. Specifically, the rates of dizziness associated with melatonin use were measured, showing a relatively low occurrence.

While it did not provide the most substantial improvement in sleep quality, melatonin showed promise in enhancing tolerability among users. Only 10% of participants reported dizziness, which indicates that melatonin might be a safer option for those worried about side effects from more potent medications. By choosing melatonin, patients can potentially find a balance between managing sleep disturbances while minimizing unwanted symptoms like dizziness.

Overall, we observed that for individuals focused on avoiding adverse effects, melatonin serves as a viable alternative within this treatment landscape. Its effectiveness in curbing dizziness contributes to discussions on how best to treat sleep disorders in psychiatric patients without compromising their comfort.

Improved sleep quality

Most Useful Review

2 people found this helpful

This has proven effective. Since taking magnesium and Sleep Deep, my sleep quality has significantly improved. I can now attain deep sleep and feel much better during the day, with no dizziness or discomfort, which is a relief.

Headache details

Agomelatine relieves hypnic headaches

Based on 15 Researches

Xu SY, Li L, Sun WX, Shen JY, Li CX. Case report: Hypnic headache responds to agomelatine-a potential prophylactic treatment option. Front Neurol. 2023;14:1179391. doi:10.3389/fneur.2023.1179391

We explored how melatonin-based treatments, particularly agomelatine, can affect headaches, focusing on hypnic headaches (HH). This form of headache typically occurs during sleep, disrupting the rest of those affected. A fascinating case of a 58-year-old woman who experienced these nocturnal headaches for three years demonstrated the potential benefits of agomelatine.

After being prescribed 25 mg of agomelatine at bedtime, she reported an impressive 80% reduction in headache frequency and severity within a month. Remarkably, her headaches completely resolved after three months, allowing her to discontinue the medication.

This case highlights the importance of exploring prophylactic treatments aimed at reducing nighttime awakenings caused by HH. Given the significant impact these headaches can have on sleep quality in older populations, treatments that target melatonin receptors could offer a promising avenue for relieving this condition.

Good for headaches

Most Useful Review

1 people found this helpful

My neurologist advised taking 3 mg nightly to alleviate symptoms of trigeminal autonomic cephalalgia. This is more effective and less taxing than other medications, which caused debilitating side effects.

Sleep Apnea details