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Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Magnesium (as Magnesium Oxide)
250 mg
60%
The product is found useful for the following medical conditions
Anxiety
SCIENTIFIC SCORE
Questionable
Based on 12 Researches
6.9
USERS' SCORE
Excellent
Based on 26 Reviews
9
8
Magnesium treats anxiety in MS
Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress.
Most Relevant Research
We aimed to understand the impact of nanoparticulate magnesium hydride (MgH) on anxiety and depression associated with multiple sclerosis (MS). Our exploration involved studying how MgH affects mood disorders in a model we designed, specifically using experimental autoimmune encephalomyelitis (EAE) mice.
We discovered that MgH treatment significantly alleviated anxiety and depression-like behaviors in these mice. Not only did MgH help improve their mood, but it also reduced overall disease severity and inflammatory damage within the central nervous system.
Importantly, our findings suggest that MgH could be working by promoting healthier microglial activity. It appears to encourage the beneficial M2 polarization while inhibiting the harmful M1 polarization, alongside reducing oxidative stress. This mechanism offers a glimpse into how magnesium might truly enhance well-being for those dealing with MS-related psychiatric issues.
In summary, our research indicates that nanoparticulate MgH holds promise as a non-toxic and effective treatment option for anxiety and depression in people suffering from MS, showcasing a potential breakthrough in managing these debilitating conditions.
We discovered that MgH treatment significantly alleviated anxiety and depression-like behaviors in these mice. Not only did MgH help improve their mood, but it also reduced overall disease severity and inflammatory damage within the central nervous system.
Importantly, our findings suggest that MgH could be working by promoting healthier microglial activity. It appears to encourage the beneficial M2 polarization while inhibiting the harmful M1 polarization, alongside reducing oxidative stress. This mechanism offers a glimpse into how magnesium might truly enhance well-being for those dealing with MS-related psychiatric issues.
In summary, our research indicates that nanoparticulate MgH holds promise as a non-toxic and effective treatment option for anxiety and depression in people suffering from MS, showcasing a potential breakthrough in managing these debilitating conditions.
9.5
Mood improvement
Most Useful Review
I periodically purchase this Magnesium. It offers great value and dosage, and I find the quality satisfactory. After taking it for about two months, I've noticed a significant uplift in my mood, especially during premenstrual syndrome. My sleep has normalised, and my anxiety has lessened. I haven’t experienced any muscle cramps in ages and feel more invigorated. The benefits are tangible, and the product works effectively.
Back Pain
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.3
USERS' SCORE
Excellent
Based on 13 Reviews
9
9.5
Magnesium reduces postoperative back pain
Effect of perioperative intravenous magnesium sulfate on postoperative pain after iliac venous stenting.
Most Relevant Research
We explored the effectiveness of magnesium sulfate (MS) in relieving low back pain (LBP) for patients who underwent iliac venous stenting. This study involved 97 patients, divided into two groups: one received MS infusion during their surgery, while the other did not.
Patients who received MS experienced significantly lower pain levels at all follow-up intervals. We found that, at 24 hours after surgery, those in the magnesium group consumed much less tramadol—a common pain medication—compared to the control group. Additionally, the need for extra pain relief was lower among those who received magnesium.
Importantly, the side effects like nausea and vomiting were similar in both groups, indicating that magnesium can be a safe option for pain management after this type of surgery. Overall, the findings suggest that magnesium sulfate not only alleviates pain but also reduces reliance on opioids, making it a valuable treatment for postoperative care.
Patients who received MS experienced significantly lower pain levels at all follow-up intervals. We found that, at 24 hours after surgery, those in the magnesium group consumed much less tramadol—a common pain medication—compared to the control group. Additionally, the need for extra pain relief was lower among those who received magnesium.
Importantly, the side effects like nausea and vomiting were similar in both groups, indicating that magnesium can be a safe option for pain management after this type of surgery. Overall, the findings suggest that magnesium sulfate not only alleviates pain but also reduces reliance on opioids, making it a valuable treatment for postoperative care.
9.5
Significant pain relief
Most Useful Review
Sciatic nerve success. My mother called me a genius after I sent her some of this to alleviate sciatica. She has a disc in her back out of place and claims she hasn't felt this good in 15 years. Initially, she took 2 pills twice daily and is now down to just 2 pills in the evening. In her words, she has forgotten what it feels like to be free of pain since starting this. I hope this natural medicine works for you too!
Leg Cramps
SCIENTIFIC SCORE
Likely Ineffective
Based on 16 Researches
4.7
USERS' SCORE
Excellent
Based on 18 Reviews
9
9
Magnesium oxide treats leg cramps
A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.
Most Relevant Research
We conducted a study to evaluate how effective magnesium oxide monohydrate (MOMH) is in treating nocturnal leg cramps (NLC). This was a randomized, double-blind, placebo-controlled trial involving multiple centers in Ukraine, where participants took either MOMH or a placebo nightly for 60 days.
Our focus was on measuring the frequency and duration of cramps, the pain they caused, and how they affected sleep quality and overall life satisfaction. We used thorough statistical methods to compare the results between the two groups.
The findings indicated that MOMH is both effective and safe for individuals dealing with NLC. Participants reported improvements in their symptoms, demonstrating that this magnesium supplement can play a helpful role in managing nocturnal leg cramps.
Our focus was on measuring the frequency and duration of cramps, the pain they caused, and how they affected sleep quality and overall life satisfaction. We used thorough statistical methods to compare the results between the two groups.
The findings indicated that MOMH is both effective and safe for individuals dealing with NLC. Participants reported improvements in their symptoms, demonstrating that this magnesium supplement can play a helpful role in managing nocturnal leg cramps.
10
Leg cramps eliminated
Most Useful Review
Cured my leg cramps! I endured nightly leg cramps for years. I began taking calcium magnesium capsules before bed, which helped but didn’t fully eliminate the cramps. I would still awaken with terrible leg cramps at least once each night, needing magnesium spray for relief. However, since starting these tablets before bed, I’ve had NO CRAMPS at all! For the first time in five years, I’m cramp-free! I highly recommend these!
Chronic Fatigue Syndrome
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 18 Reviews
8.9
9.5
Mood enhancement
Most Useful Review
Periodically, I purchase this magnesium. It’s a great price and dosage. The quality is satisfactory – I take it for about two months. It significantly improves my mood, especially during premenstrual syndrome, normalises sleep, and alleviates anxiety. Previously, I often experienced muscle cramps in my feet, but I no longer feel this. I feel more energised, and the benefits are clear.
Heart Disease
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 19 Reviews
8.8
9.5
Improved heart health
Most Useful Review
This medication has benefits for bone density, heart rate management, and preventing heart disease. I found that my sleep returned to normal on the first day, and my irritability vanished. I've noticed increased efficiency, concentration, and a sense of well-being. Overall, I highly recommend it.
Sleep Apnea
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 13 Reviews
8.8
7
Magnesium's role in sleep apnea
Association between magnesium deficiency score and sleep quality in adults: A population-based cross-sectional study.
Most Relevant Research
We aimed to uncover the relationship between magnesium levels and sleep quality, particularly focusing on sleep apnea. Our study analyzed data from a large group of adults aged 20 and older, using a well-structured method to assess magnesium levels and the prevalence of sleep issues.
We found a notable connection between lower magnesium levels, measured as the magnesium depletion score (MDS), and the likelihood of experiencing sleep apnea. Specifically, individuals with higher MDS levels were significantly more likely to report sleep apnea, showing over three times the odds compared to those with adequate magnesium levels.
Interestingly, our research did not link magnesium deficiency to other sleep problems like insomnia or restless legs syndrome, suggesting a more complex relationship with sleep apnea alone. Additionally, we noticed that older adults with depressive symptoms showed a tendency toward excessive sleep rather than insufficient sleep.
While our findings highlight the association between magnesium deficiency and sleep apnea, they also point towards the potential of adequate magnesium intake in reducing this risk. This emphasizes the importance of maintaining proper magnesium levels for better sleep quality, especially in those at higher risk for sleep apnea.
We found a notable connection between lower magnesium levels, measured as the magnesium depletion score (MDS), and the likelihood of experiencing sleep apnea. Specifically, individuals with higher MDS levels were significantly more likely to report sleep apnea, showing over three times the odds compared to those with adequate magnesium levels.
Interestingly, our research did not link magnesium deficiency to other sleep problems like insomnia or restless legs syndrome, suggesting a more complex relationship with sleep apnea alone. Additionally, we noticed that older adults with depressive symptoms showed a tendency toward excessive sleep rather than insufficient sleep.
While our findings highlight the association between magnesium deficiency and sleep apnea, they also point towards the potential of adequate magnesium intake in reducing this risk. This emphasizes the importance of maintaining proper magnesium levels for better sleep quality, especially in those at higher risk for sleep apnea.
9.5
Improved sleep quality
Most Useful Review
This medication addresses my heart issues, including sleep apnea, and alleviates irritability. It maintains bone density and supports my heart rate, which is important as I experience tachycardia. After starting this medication, I fell asleep quickly and enjoyed restful sleep. My concentration improved, enabling me to accomplish more throughout the day. I highly recommend it!
Heart Attack
SCIENTIFIC SCORE
Questionable
Based on 14 Researches
6.7
USERS' SCORE
Good
Based on 6 Reviews
8.7
9
Magnesium implantation improves heart recovery
Magnesium implantation as a continuous hydrogen production generator for the treatment of myocardial infarction in rats.
Most Relevant Research
We explored the potential of magnesium implantation as a new approach to combat heart attacks, specifically myocardial infarction (MI). Our research centered on using magnesium slices implanted under the skin of rats to generate hydrogen gas continuously. This method could ensure a greater and longer-lasting concentration of hydrogen directly reaching the heart, which is crucial for its therapeutic effects.
Through our study, we measured how effectively the magnesium produced hydrogen and evaluated its safety. The results were promising; we observed that magnesium implantation not only improved cardiac function in rats suffering from MI, but also played a role in eliminating harmful free radicals from mitochondrial dysfunction. Furthermore, it helped reduce cell death in heart muscle cells, which is a common consequence of heart attacks.
Compared to traditional hydrogen inhalation, which has limitations in delivering sufficient doses over time, magnesium implantation proved to be a superior method. Overall, our findings pave the way for innovative treatments that could enhance recovery after heart attacks by harnessing the unique properties of magnesium for hydrogen production.
Through our study, we measured how effectively the magnesium produced hydrogen and evaluated its safety. The results were promising; we observed that magnesium implantation not only improved cardiac function in rats suffering from MI, but also played a role in eliminating harmful free radicals from mitochondrial dysfunction. Furthermore, it helped reduce cell death in heart muscle cells, which is a common consequence of heart attacks.
Compared to traditional hydrogen inhalation, which has limitations in delivering sufficient doses over time, magnesium implantation proved to be a superior method. Overall, our findings pave the way for innovative treatments that could enhance recovery after heart attacks by harnessing the unique properties of magnesium for hydrogen production.
9.5
Nervous system support
Most Useful Review
The carefully formulated magnesium complex in this drug meets daily needs, aiding muscle function and protecting against vascular diseases. It effectively supports the nervous system, reducing fatigue and cleansing the body of toxins. I recommend taking one capsule a day with meals. If helpful, please click đź‘Ť; thank you.
Cardiovascular Disease
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.6
USERS' SCORE
Good
Based on 8 Reviews
8.6
8
Magnesium's impact on heart health
The Role of Dietary Magnesium in Cardiovascular Disease.
Most Relevant Research
We examined the connection between dietary magnesium and cardiovascular disease, focusing on how magnesium intake or serum levels relate to heart health. Over the last couple of decades, numerous studies have shown that low magnesium levels are associated with several heart-related issues, including high blood pressure, heart attacks, and even heart failure.
Our insights reveal that even mild or moderate magnesium deficiencies can trigger physiological and metabolic changes that may heighten cardiovascular risks. When magnesium levels are insufficient, we see a rise in inflammation, oxidative stress, and issues with how fats are processed in the body, which can lead to serious heart problems.
Furthermore, we noted that many individuals often consume less magnesium than what is recommended, particularly those who do not regularly eat whole grains, legumes, or green vegetables. This widespread lack of magnesium is concerning, as it could be a significant factor influencing heart disease in the general population.
Our insights reveal that even mild or moderate magnesium deficiencies can trigger physiological and metabolic changes that may heighten cardiovascular risks. When magnesium levels are insufficient, we see a rise in inflammation, oxidative stress, and issues with how fats are processed in the body, which can lead to serious heart problems.
Furthermore, we noted that many individuals often consume less magnesium than what is recommended, particularly those who do not regularly eat whole grains, legumes, or green vegetables. This widespread lack of magnesium is concerning, as it could be a significant factor influencing heart disease in the general population.
8.8
Improved heart health
Most Useful Review
I have heart issues, sleep problems, and constant fatigue. This medication helps maintain bone density, regulates my heartbeat, and prevents cardiovascular disease. After the first dose, I slept soundly and felt refreshed. Irritability vanished instantly, boosting my concentration and productivity. I highly recommend it!
Headache
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8
USERS' SCORE
Good
Based on 14 Reviews
8.6
9
We explored the impact of magnesium on migraine headaches, focusing on its potential benefits based on various studies. Magnesium deficiency is quite common and can arise from different factors, such as not consuming enough through diet or losing more through bodily systems.
A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.
This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.
A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.
This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.
8.8
Relieves headaches
Most Useful Review
Magnesium is essential for various bodily functions, including energy metabolism and nerve impulses. I take one Nature Made Magnesium tablet of 250 mg at night, and it significantly relaxes me and helps with my headaches. There were no gastrointestinal side effects, and it has improved my mood and reduced headaches overall.
Hair Loss
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 1 Review
8.6
9
3D micropattern enhances hair regrowth
3D multicellular micropatterning biomaterials for hair regeneration and vascularization.
Most Relevant Research
We explored a novel approach to tackle hair loss by using a 3D multicellular micropattern that includes magnesium silicate (MS) nanomaterials. This innovative method involved carefully positioning hair follicle-related cells in a structured network along with vascular cells, all created through advanced bioprinting techniques.
The incorporation of magnesium silicate aimed to enhance both hair follicle potential and the formation of new blood vessels—factors crucial for healthy hair growth. Our findings revealed promising results, showing that this 3D micropattern with MS significantly promoted hair regrowth in models of skin tissue regeneration, including both immunodeficient mice and those with androgenetic alopecia.
Essentially, we demonstrated that integrating magnesium with a well-designed cell arrangement could lead to better hair restoration outcomes. This significant insight contributes to the ongoing search for effective treatments for hair loss, bridging biological engineering and dermatology in the process.
The incorporation of magnesium silicate aimed to enhance both hair follicle potential and the formation of new blood vessels—factors crucial for healthy hair growth. Our findings revealed promising results, showing that this 3D micropattern with MS significantly promoted hair regrowth in models of skin tissue regeneration, including both immunodeficient mice and those with androgenetic alopecia.
Essentially, we demonstrated that integrating magnesium with a well-designed cell arrangement could lead to better hair restoration outcomes. This significant insight contributes to the ongoing search for effective treatments for hair loss, bridging biological engineering and dermatology in the process.
9.5
Prevents hair loss
Most Useful Review
Must buy! A cheaper way to help prevent hair loss. It has really helped. My hair has always shed a lot, and following a diet, I lost an extreme amount. Since I started taking it once a day, my hair loss has become very minimal.
Migraine
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.3
USERS' SCORE
Good
Based on 3 Reviews
8.6
9
We explored how magnesium supplementation can help alleviate migraines, a condition that affects countless individuals and can be incredibly disabling. Research has shown a strong link between magnesium deficiency and various factors that contribute to migraines, such as neurological changes and inflammation.
Studies, including randomized controlled trials, indicate that magnesium can reduce the frequency and severity of migraine attacks, both in the short term and as a preventative measure. This effectiveness is thought to stem from magnesium's ability to influence nerve function and reduce stress responses in the body.
We've examined the accumulating evidence from case studies and clinical trials, and it clearly points to magnesium being a valuable option for those suffering from migraines. By addressing magnesium deficiency, we may offer a new avenue for relief and improved management of this challenging condition.
Studies, including randomized controlled trials, indicate that magnesium can reduce the frequency and severity of migraine attacks, both in the short term and as a preventative measure. This effectiveness is thought to stem from magnesium's ability to influence nerve function and reduce stress responses in the body.
We've examined the accumulating evidence from case studies and clinical trials, and it clearly points to magnesium being a valuable option for those suffering from migraines. By addressing magnesium deficiency, we may offer a new avenue for relief and improved management of this challenging condition.
9.5
Immediate relief
Most Useful Review
I purchase these to help with my migraines, and I'm here to confirm that it works! I take two at night, and when a migraine starts, it can either alleviate it or completely get rid of it.
Blood Clot
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.5
9
Lowered blood pressure
Most Useful Review
A good supplement I ordered for my mother. She has high blood pressure and heart issues, and this supplement has helped reduce her blood pressure. The tablets are small, easy to swallow, and taste neutral. Magnesium supports health in various ways, which is vital considering its role in preventing complications like blood clots.
Cancer
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.6
USERS' SCORE
Good
Based on 1 Review
8.5
8
Magnesium alloy inhibits cancer growth
Biodegradable Mg-1%Ca alloy inhibits the growth of cervical cancer.
Most Relevant Research
We explored how magnesium alloy, particularly a variant containing 1% calcium, impacts cervical cancer cells. Our investigation revealed that this alloy has promising antitumor properties which could pave the way for new treatments.
In our experiments, we tested the effects of the Mg-1%Ca alloy both in laboratory settings and in living organisms. This alloy was found to release magnesium ions and hydroxide ions more slowly than expected. We observed that it effectively inhibited the growth of cervical cancer cells, specifically SiHa and HeLa cell lines.
Additionally, the presence of the alloy induced apoptosis, or programmed cell death, in the cancer cells, disrupted their structural integrity, and hindered their ability to migrate and invade other tissues. Importantly, the Mg-1%Ca alloy was seen to influence key molecular pathways, specifically the MAPK/ERK signaling pathway, which plays a role in cancer cell proliferation.
With these results, it's evident that magnesium alloy could serve as a useful adjunct to current cervical cancer therapies, potentially helping to prevent both cancer growth and metastasis.
In our experiments, we tested the effects of the Mg-1%Ca alloy both in laboratory settings and in living organisms. This alloy was found to release magnesium ions and hydroxide ions more slowly than expected. We observed that it effectively inhibited the growth of cervical cancer cells, specifically SiHa and HeLa cell lines.
Additionally, the presence of the alloy induced apoptosis, or programmed cell death, in the cancer cells, disrupted their structural integrity, and hindered their ability to migrate and invade other tissues. Importantly, the Mg-1%Ca alloy was seen to influence key molecular pathways, specifically the MAPK/ERK signaling pathway, which plays a role in cancer cell proliferation.
With these results, it's evident that magnesium alloy could serve as a useful adjunct to current cervical cancer therapies, potentially helping to prevent both cancer growth and metastasis.
8.8
Improved sleep
Most Useful Review
I purchased this for my husband, who is fighting stage 4 cancer. It has alleviated his anxiety and appears safe for him with no side effects. He seems to be sleeping better as well. Quick dispatch, will buy again.
Diabetes
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.3
USERS' SCORE
Good
Based on 1 Review
8.5
8
Magnesium deficiency affects diabetes control
Hypomagnesemia in adults with type 2 diabetes mellitus in Riyadh, Saudi Arabia: A cross-sectional study.
Most Relevant Research
We looked into how magnesium levels relate to diabetes, specifically focusing on adults with type 2 diabetes mellitus (T2DM) in Riyadh, Saudi Arabia. Conducted as a cross-sectional study, we analyzed data from 294 individuals, including T2DM patients, prediabetics, and nondiabetic controls. Our goal was to uncover the prevalence of magnesium deficiency and its potential effects on various metabolic factors.
The findings revealed a striking difference in magnesium levels across the groups. T2DM patients exhibited notably lower magnesium than those with prediabetes and nondiabetic controls. This deficiency was linked to worse metabolic outcomes, including higher fasting glucose and glycated hemoglobin (HbA1c) levels, as well as increased insulin resistance.
We noted a strong negative correlation between magnesium levels and both glucose and HbA1c, suggesting that as magnesium levels decrease, diabetes control worsens. Interestingly, our analysis indicated that magnesium levels could effectively predict higher HbA1c values, highlighting the need for regular monitoring of magnesium in diabetes management.
While our study emphasizes the significant impact of magnesium deficiency on the metabolic health of T2DM patients, it also opens the door for further exploration regarding the benefits of magnesium supplementation in diabetes care. Overall, these insights push us to consider the broader implications of maintaining proper magnesium levels for better diabetes management.
The findings revealed a striking difference in magnesium levels across the groups. T2DM patients exhibited notably lower magnesium than those with prediabetes and nondiabetic controls. This deficiency was linked to worse metabolic outcomes, including higher fasting glucose and glycated hemoglobin (HbA1c) levels, as well as increased insulin resistance.
We noted a strong negative correlation between magnesium levels and both glucose and HbA1c, suggesting that as magnesium levels decrease, diabetes control worsens. Interestingly, our analysis indicated that magnesium levels could effectively predict higher HbA1c values, highlighting the need for regular monitoring of magnesium in diabetes management.
While our study emphasizes the significant impact of magnesium deficiency on the metabolic health of T2DM patients, it also opens the door for further exploration regarding the benefits of magnesium supplementation in diabetes care. Overall, these insights push us to consider the broader implications of maintaining proper magnesium levels for better diabetes management.
8.8
Cramps relief
Most Useful Review
This product effectively alleviates my leg, feet, and hand cramps caused by type 1 diabetes. I've tried various remedies, but this magnesium works the best. I can take one when cramps start, and relief usually comes within 20 minutes.
Hot Flashes
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 1 Review
8.5
8
Magnesium may ease hot flashes
A pilot phase II trial of magnesium supplements to reduce menopausal hot flashes in breast cancer patients.
Most Relevant Research
We set out to explore whether magnesium could alleviate the uncomfortable hot flashes experienced by breast cancer patients. In our pilot study, we enrolled women who reported having at least 14 hot flashes a week and administered magnesium oxide. The dosage started at 400 mg for four weeks, and we allowed it to escalate to 800 mg if necessary.
Among the 29 women who joined, 25 completed the treatment, with an average age of 53.5 years. We found that the frequency of hot flashes decreased significantly, dropping from an average of 52.2 per week to 27.7, which is a 41.4% reduction. The overall hot flash score, which combines frequency and severity, also showed improvement, reducing by over 50%. More than half of the participants reported that their hot flashes had decreased by more than 50%, and nearly three-quarters experienced at least a 25% reduction.
Side effects were minimal, with only a couple of women discontinuing the treatment due to headache and nausea. Overall, compliance was excellent, and many participants chose to continue taking magnesium even after the study ended. As such, the results suggest that oral magnesium could be a promising option for managing hot flashes, encouraging further research through a randomized placebo-controlled trial.
Among the 29 women who joined, 25 completed the treatment, with an average age of 53.5 years. We found that the frequency of hot flashes decreased significantly, dropping from an average of 52.2 per week to 27.7, which is a 41.4% reduction. The overall hot flash score, which combines frequency and severity, also showed improvement, reducing by over 50%. More than half of the participants reported that their hot flashes had decreased by more than 50%, and nearly three-quarters experienced at least a 25% reduction.
Side effects were minimal, with only a couple of women discontinuing the treatment due to headache and nausea. Overall, compliance was excellent, and many participants chose to continue taking magnesium even after the study ended. As such, the results suggest that oral magnesium could be a promising option for managing hot flashes, encouraging further research through a randomized placebo-controlled trial.
8.5
Reduced night sweats
Most Useful Review
Reduced my night sweats! I’ve been taking magnesium for six months, primarily for heart benefits, but I've also noticed no more leg cramps, regular bowel movements, and reduced night sweats and hot flashes. I take one tablet before bed along with the morning dose.
Neuropathy
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.6
USERS' SCORE
Good
Based on 1 Review
8.5
9
Magnesium's potential in neuropathy treatment
Interaction between magnesium and methylglyoxal in diabetic polyneuropathy and neuronal models.
Most Relevant Research
A recent study explored the connection between magnesium levels and diabetic sensorimotor polyneuropathy. We measured serum magnesium and plasma methylglyoxal levels in recently diagnosed type 2 diabetes patients—some with neuropathy and others without.
Our findings revealed that patients with neuropathy had significantly lower magnesium levels, which were inversely related to higher methylglyoxal levels. This interaction appeared to contribute to nerve dysfunction, making magnesium's role particularly interesting in the context of neuropathy.
We found that magnesium supplementation could protect nerve cells from the neurotoxic effects of methylglyoxal in laboratory models. Importantly, when magnesium was added, we observed improvements in cell health, suggesting that maintaining magnesium levels might be a promising strategy for mitigating diabetic neuropathy.
Overall, our research highlights a compelling link between magnesium deficiency and nerve damage, suggesting that addressing magnesium levels could hold the key to new treatment approaches for diabetic neuropathy and possibly other neurodegenerative conditions.
Our findings revealed that patients with neuropathy had significantly lower magnesium levels, which were inversely related to higher methylglyoxal levels. This interaction appeared to contribute to nerve dysfunction, making magnesium's role particularly interesting in the context of neuropathy.
We found that magnesium supplementation could protect nerve cells from the neurotoxic effects of methylglyoxal in laboratory models. Importantly, when magnesium was added, we observed improvements in cell health, suggesting that maintaining magnesium levels might be a promising strategy for mitigating diabetic neuropathy.
Overall, our research highlights a compelling link between magnesium deficiency and nerve damage, suggesting that addressing magnesium levels could hold the key to new treatment approaches for diabetic neuropathy and possibly other neurodegenerative conditions.
8.8
Relief from cramps
Most Useful Review
Works wonderfully for my leg, feet and hand cramps. I experience body cramps, predominantly in my legs, feet and hands, as a result of neuropathy from type 1 diabetes. I've tried bananas, vinegar, mustard, and all sorts of other remedies. This magnesium appears to help the most; I can take one as soon as the cramping begins, and relief typically comes within 20 minutes.
Tinnitus
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8
USERS' SCORE
Good
Based on 1 Review
8.5
8
Magnesium's role in tinnitus explored
Relationship between serum magnesium level and subjective tinnitus.
Most Relevant Research
We explored the connection between serum magnesium levels and the occurrence of severe bilateral subjective tinnitus. This study involved 76 patients suffering from this distressing condition and compared them to 86 healthy participants.
By measuring and analyzing the magnesium levels in both groups, we observed that those with tinnitus had significantly lower magnesium concentrations—1.8 mg/dL compared to 2.3 mg/dL in the control group. This difference suggests that magnesium may play a role in the body’s response to tinnitus.
Our findings indicate that magnesium could be an important factor in understanding the pathophysiology of subjective tinnitus. While this doesn’t confirm that magnesium treatment will alleviate tinnitus symptoms, it certainly opens up avenues for further research in this area.
By measuring and analyzing the magnesium levels in both groups, we observed that those with tinnitus had significantly lower magnesium concentrations—1.8 mg/dL compared to 2.3 mg/dL in the control group. This difference suggests that magnesium may play a role in the body’s response to tinnitus.
Our findings indicate that magnesium could be an important factor in understanding the pathophysiology of subjective tinnitus. While this doesn’t confirm that magnesium treatment will alleviate tinnitus symptoms, it certainly opens up avenues for further research in this area.
8.8
Great for ear issues
Most Useful Review
This has significantly reduced my tinnitus and I believe it has helped prevent hearing loss commonly associated with Meniere's disease. The price is reasonable, and the product is worth much more. I highly recommend it for any ear problems or conditions. You won't regret it. Buy it now!
High Cholesterol
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.4
9.5
Lowers blood pressure
Most Useful Review
I order this supplement for my mother, who has high blood pressure and heart issues. After taking it, her blood pressure decreases. The product quality is excellent, and the small tablets are easy to swallow. Magnesium supports nervous, muscular, heart, and bone health.
Knee Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.4
8.3
Improved knee pain
Most Useful Review
Magnesium is crucial for our health and involved in numerous processes. A lack of magnesium affects well-being. I took Magnesium from Nature Made to help normalise sleep and noted improvements. My knee pain has lessened since I started taking it, and I'm sleeping soundly.
Pelvic Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 10 Reviews
8.4
9.5
Stops leg cramps
Most Useful Review
I purchased it for my husband, who constantly experienced leg cramps. After a week of consistent use, he no longer suffers from discomfort.
Irritable Bowel Syndrome
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 7 Reviews
8.3
8
Magnesium boosts colonic activity
Effects of oral magnesium sulphate on colonic motility in patients with the irritable bowel syndrome.
Most Relevant Research
We set out to understand how magnesium sulphate influences the symptoms of irritable bowel syndrome (IBS). In a study involving 20 IBS patients, magnesium sulphate was administered orally, resulting in a quick boost in colonic motor activity. Most participants experienced this increase within just two to six minutes.
Specifically, the percentage of colonic activity rose from 16.2% to 23.7%, signaling a notable change. Those who often felt abdominal pain after eating showed even more pronounced reactions, with their activity jumping from 16.1% to 29.8%. However, it’s important to note that three of these patients still experienced their usual pain after taking magnesium, suggesting that while magnesium can enhance motility, it doesn’t eliminate the pain for everyone.
Ultimately, these findings lend support to the idea that some cases of abdominal pain related to food may stem from heightened intestinal responses to cholecystokinin, a hormone released by the intestine. So while magnesium shows promise for intriguing changes in colonic movement in IBS patients, its effectiveness in alleviating pain remains mixed.
Specifically, the percentage of colonic activity rose from 16.2% to 23.7%, signaling a notable change. Those who often felt abdominal pain after eating showed even more pronounced reactions, with their activity jumping from 16.1% to 29.8%. However, it’s important to note that three of these patients still experienced their usual pain after taking magnesium, suggesting that while magnesium can enhance motility, it doesn’t eliminate the pain for everyone.
Ultimately, these findings lend support to the idea that some cases of abdominal pain related to food may stem from heightened intestinal responses to cholecystokinin, a hormone released by the intestine. So while magnesium shows promise for intriguing changes in colonic movement in IBS patients, its effectiveness in alleviating pain remains mixed.
9.5
Constipation relief
Most Useful Review
My honest review. I chose magnesium oxide for my elderly mother, who suffered from constipation. After two weeks of taking it, her bowel movements improved to daily or even twice a day. The cramps in her legs ceased, and she also noted better calmness and sleep quality. It's budget-friendly and lasts for over three months. I hope my review helps someone else facing the same issues.
Bloating
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.5
USERS' SCORE
Good
Based on 1 Review
8.3
8
Magnesium alleviates menstrual bloating
Magnesium supplementation alleviates premenstrual symptoms of fluid retention.
Most Relevant Research
We explored the impact of magnesium supplementation on bloating as part of a larger study examining premenstrual symptoms. In our randomized, double-blind, placebo-controlled design, we administered a daily dose of 200 mg of magnesium (as MgO) to participants over the course of two menstrual cycles. Each volunteer kept track of their symptoms using a detailed diary with twenty-two items.
Initially, we found no difference in premenstrual symptoms between the magnesium and placebo groups during the first month. However, during the second month, participants taking magnesium experienced a notable decrease in bloating and hydration-related symptoms such as weight gain and breast tenderness. This reduction in symptoms was statistically significant, indicating that magnesium can indeed alleviate certain premenstrual symptoms like bloating.
Our findings suggest that magnesium supplementation, particularly in the context of fluid retention and bloating, could be beneficial for women experiencing these discomforts during their menstrual cycle. Overall, this study opens the door to considering magnesium as an effective remedy for mild premenstrual bloating.
Initially, we found no difference in premenstrual symptoms between the magnesium and placebo groups during the first month. However, during the second month, participants taking magnesium experienced a notable decrease in bloating and hydration-related symptoms such as weight gain and breast tenderness. This reduction in symptoms was statistically significant, indicating that magnesium can indeed alleviate certain premenstrual symptoms like bloating.
Our findings suggest that magnesium supplementation, particularly in the context of fluid retention and bloating, could be beneficial for women experiencing these discomforts during their menstrual cycle. Overall, this study opens the door to considering magnesium as an effective remedy for mild premenstrual bloating.
5.8
Sleep improvement
Most Useful Review
Works great, just take with a meal. After a recent blood test, I was told my magnesium level is slightly low and to consider a supplement. I've been taking this for about a week and I've noticed improved sleep and relaxed leg muscles after activities like bike riding. I find it easier on my stomach when taken with a meal. If I take it on an empty stomach, I experience minor cramps, bloating, and diarrhoea the next day. However, when taken with dinner, there are no issues. I once forgot to take it and woke up with stiff, crampy legs, but since resuming my routine, I've had no problems.
Diarrhea
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.6
USERS' SCORE
Good
Based on 4 Reviews
8.3
9.5
Magnesium shows potential for diarrhea
Mg2+ supplementation treats secretory diarrhea in mice by activating calcium-sensing receptor in intestinal epithelial cells.
Most Relevant Research
We explored the impact of magnesium on secretory diarrhea, particularly in the context of cholera, a significant global health issue. The focus was on understanding how magnesium, often overlooked, could serve as an effective treatment option. In our study, we found that increasing levels of magnesium can significantly inhibit chloride secretion in intestinal cells, which is crucial during episodes of diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
6.8
Diarrhea when taken incorrectly
Most Useful Review
Works well, but remember to take it with a meal. After a blood test showed low magnesium, I started taking this supplement. It improved my sleep and muscle relaxation, though taking it on an empty stomach caused me cramps and diarrhoea. By taking it with dinner, I’ve had no issues since.
Constipation
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.6
USERS' SCORE
Moderately Good
Based on 32 Reviews
7.8
4
Effectiveness of magnesium on constipation
Effect of reduced daily magnesium oxide doses on laxative effect: a single-center retrospective study.
Most Relevant Research
We explored how changing the frequency of magnesium oxide (MgO) doses influences its effectiveness in relieving constipation. In this study, we looked at 11 patients who had been regularly using MgO to manage their bowel movements and decided to reduce their daily dose frequency over two weeks.
Initially, patients were taking magnesium three times a day, but we reduced this to either two or one dose per day while keeping the total amount the same. We found that the average number of bowel movements dropped from 7.6 to 6.6 in this period. However, this change wasn't statistically significant, indicating that it may not be clinically meaningful.
Additionally, we measured stool consistency using the Bristol Stool Form Scale and noted no significant difference before and after the dosage adjustment. Our findings suggest that reducing the number of doses does not impact the laxative effect of magnesium oxide. This implies that patients can comfortably manage their magnesium intake without sacrificing effectiveness.
Initially, patients were taking magnesium three times a day, but we reduced this to either two or one dose per day while keeping the total amount the same. We found that the average number of bowel movements dropped from 7.6 to 6.6 in this period. However, this change wasn't statistically significant, indicating that it may not be clinically meaningful.
Additionally, we measured stool consistency using the Bristol Stool Form Scale and noted no significant difference before and after the dosage adjustment. Our findings suggest that reducing the number of doses does not impact the laxative effect of magnesium oxide. This implies that patients can comfortably manage their magnesium intake without sacrificing effectiveness.
9
Keeps me regular
Most Useful Review
Fantastic for maintaining regularity. As an herbalist, I primarily use this to avoid addictive medications for irregularities or constipation. It’s a much healthier option and doesn’t cause diarrhoea. This magnesium performs better than others I've used, so I repeatedly buy it.
Chest Pain
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.1
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.5
8
Magnesium supplementation aids chest pain
The prevalence of hypomagnesaemia in pediatric patients with mitral valve prolapse syndrome and the effect of mg therapy.
Most Relevant Research
We explored the effects of magnesium treatment on chest pain in pediatric patients suffering from mitral valve prolapse syndrome. In our study involving 230 young participants, we defined hypomagnesaemia as having a serum magnesium level below 1.5 mg/dl.
After identifying 19 patients with insufficient magnesium levels—representing about 8.2% of the group—we treated them with an oral magnesium chloride supplement for five weeks. We were eager to see whether this would help alleviate symptoms, particularly chest pain.
After the treatment period, we observed that magnesium therapy provided statistically significant relief of chest pain for these patients. However, we did not find substantial improvements in other symptoms like palpitations, fatigue, and dyspnea. This finding is vital, as it indicates that while magnesium may play a role in easing chest pain, its overall benefit to other symptoms remains uncertain.
Overall, our study highlights the relatively low prevalence of magnesium deficiency in pediatric patients with mitral valve prolapse compared to adults. Nevertheless, we concluded that magnesium supplementation could be a beneficial approach to address specific symptoms like chest pain in this population.
After identifying 19 patients with insufficient magnesium levels—representing about 8.2% of the group—we treated them with an oral magnesium chloride supplement for five weeks. We were eager to see whether this would help alleviate symptoms, particularly chest pain.
After the treatment period, we observed that magnesium therapy provided statistically significant relief of chest pain for these patients. However, we did not find substantial improvements in other symptoms like palpitations, fatigue, and dyspnea. This finding is vital, as it indicates that while magnesium may play a role in easing chest pain, its overall benefit to other symptoms remains uncertain.
Overall, our study highlights the relatively low prevalence of magnesium deficiency in pediatric patients with mitral valve prolapse compared to adults. Nevertheless, we concluded that magnesium supplementation could be a beneficial approach to address specific symptoms like chest pain in this population.
9
Calms tension
Most Useful Review
Excellent magnesium; it calms my central nervous system and alleviates pain and swelling. However, when I stopped taking it, I experienced convulsions.
