NOW Supplements Vitamin B-50 mg

The effect is remarkable! My hands and feet used to ache in the morning. It was thought that my arthritis and tight muscles were to blame, with a possibility of insufficient B vitamins for nerve impulse conduction. After starting these vitamins, I noticed a difference in just two days! I now wake up without the need to warm up my limbs. There's no tightness, but if I skip a day, the pain returns.

Athlete’s Foot details

1 people found this helpful

It has helped! After my second childbirth, I experienced skin issues on my feet, becoming very dry and crackled, which was quite painful. I discovered this might be due to a deficiency of B vitamins. After a week of taking it, the cracks have healed, and the dryness has lessened significantly. I believe within a month, I will forget about the dryness altogether. I take one capsule with breakfast, and it benefits my skin and hair overall. I combine it with vitamin C.

Candidiasis details

Cost-effective solution

I use it to stimulate the TCA cycle while addressing Candidiasis. This vitamin B is advantageous as it contains nearly the same ingredients as those in my previous molecular nutrition therapy, closely resembling what was prescribed in the hospital, yet it's much more affordable!

Celiac details

Energy levels increased

Vitamin B-50 enhances my energy and provides essential B vitamins, extra crucial as I avoid wheat and gluten. I’ve never encountered issues with this product, thanks to the high-quality ingredients from Now Brand, manufactured in their gluten-free facility. I highly recommend it.

Cold Sores details

8 people found this helpful

B vitamins are water-soluble, and apart from B-12, the body stores them in limited amounts, so I take them daily. The effect I've noticed is that I no longer catch colds and no longer suffer from cold sores!

Constipation details

Excellent remedy for constipation.

Frozen Shoulder details

6 people found this helpful

I had a shoulder tremor, and my doctor advised taking this supplement for the first three days. Thankfully, the tremor disappeared. I continued until the package was finished, and I remained free of any serious issues. It turned out I was suffering from a vitamin B deficiency.

Hot Flashes details

1 people found this helpful

It has established itself well as a vegan preparation; the condition of my skin and nails has improved, the nails have stopped exfoliating, and my hair has ceased to fall out. This excellent product during the postmenopausal period has reduced my Hot Flashes.

Multiple Sclerosis details

Fatigue reduction reported

39 people found this helpful

Living with multiple sclerosis, I fight chronic fatigue daily. This B50 vitamin has significantly aided my focus and alertness throughout the day, which is essential given my low Vitamin D levels. I highly recommend it, particularly for those managing chronic illnesses.

Cardiovascular Disease details

Wang XQ, Yin S, Wang QW, Bai WW, Tan RH, et al. Vitamin B6 allosterically activates AMPK to promote postischemic angiogenesis in mice. Eur J Pharmacol. 2025;993:177413. doi:10.1016/j.ejphar.2025.177413

Vitamin B6 aids heart recovery

We investigated how vitamin B6 supports heart recovery after heart attacks by promoting new blood vessel growth, known as angiogenesis. In laboratory tests, vitamin B6 improved cell migration and tubule formation, vital for forming new blood vessels.

Remarkably, long-term vitamin B6 supplementation showed significant improvements in heart function and reduced inflammation in mice following heart attacks. This suggests that vitamin B6 could be a beneficial aid for heart recovery, harnessing a specific pathway involving a protein called AMPK.

Normalises pressure

Most Useful Review

189 people found this helpful

Taking these B vitamins has significantly improved my health. After a month, leg pain disappeared and my sensory issues in fingers and toes were resolved. I recommend taking it alongside magnesium for better results in managing stress and blood pressure. During pregnancy, it helped keep my blood pressure stable. I’m very pleased and will order more.

Chronic Cough details

Helps with Chronic Fatigue

3 people found this helpful

This has significantly helped me deal with my fatigue due to MS! I battle chronic fatigue every day with this condition. With a low Vitamin D level, I need every bit of assistance I can obtain. I have discovered that some natural vitamins help, and this B50 stands out! I take it in the morning, which aids my focus and energy until mid-afternoon. I would recommend this, particularly for individuals with chronic illness.

Diabetes details

Myo-inositol aids diabetes management

Based on 11 Researches

Long L, Huang Q, Song T, Dai Z. Myo-inositol rescued insulin resistance and dyslipidemia in db/db mice. J Appl Biomed. 2024;22:74. doi:10.32725/jab.2024.009

We explored how Myo-inositol (MI) might help manage diabetes by studying its effects in db/db mice, a common model for type 2 diabetes. Findings showed that MI reduced high blood sugar and insulin levels, and it even improved insulin resistance, much like metformin does.

Additionally, MI lowered high triglyceride and cholesterol levels, which can benefit overall heart health. Interestingly, while it reduced fat cell formation, it didn't help control obesity in these mice. Overall, MI shows promise as a supportive treatment for hyperglycemia and related issues in diabetes patients.

Recommended for diabetics

Most Useful Review

8 people found this helpful

B vitamins need to be replenished daily, which can be challenging with meal regulation. Dietary supplements help, especially taken alongside Alpha lipoic acid, necessary for diabetics. Following my endocrinologist's advice, I take B-50 regularly four times a year. I noticed no side effects. After 2 years of low-carb eating, my sugar levels are stable, hypertension has lessened, and diabetic neuropathy has gradually improved. Highly recommend!

Heart Attack details

Vitamin B6 aids heart recovery

We explored whether vitamin B6 can aid heart recovery after a heart attack. Our study showed that vitamin B6 promotes angiogenesis, the formation of new blood vessels, which plays a key role in heart function recovery.

We observed that vitamin B6 enhances cell migration and tube formation in laboratory settings, as well as improves heart function in mice after a heart attack. While it shows promise, we must remember that these results are based on animal studies, and more research is needed before drawing conclusions for humans.

No panic attacks

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10 people found this helpful

I take it alongside c-1000 and iron for panic attacks. I'm pleased to report that since starting this regimen, I have not experienced any panic attacks.

Leg Cramps details

Vitamin B complex effective for cramps

Based on 2 Researches

Chan P, Huang TY, Chen YJ, Huang WP, Liu YC. Randomized, double-blind, placebo-controlled study of the safety and efficacy of vitamin B complex in the treatment of nocturnal leg cramps in elderly patients with hypertension. J Clin Pharmacol. 1998;38:1151.

We conducted a randomized, double-blind study to see if vitamin B complex could help older adults with nighttime leg cramps. Over three months, participants reported their cramp frequency and intensity.

The results were encouraging—86% of those taking vitamin B complex saw significant improvement, while the placebo group showed no notable changes. This suggests that vitamin B complex is a promising and safe alternative to traditional treatments like quinine, which can have unpleasant side effects.

Relieves leg cramps

Most Useful Review

189 people found this helpful

All nerves can be restored! This wonderful complex of B vitamins helped eliminate my leg cramps within a month. I experienced restored sensitivity in my fingers and toes. If you take this for therapeutic reasons, ensure to combine it with magnesium for optimal results. It's great for high blood pressure too! I also took it during pregnancy to manage blood pressure, and it worked perfectly.

Rash details

Adie MA, Martes Gomez M, Yom J, Durand M, Wertheimer F, et al. Twin Premature Infants With Riboflavin and Biotin Deficiency Presenting With Refractory Lactic Acidosis, Rash, and Multiorgan Failure During Prolonged Parenteral Nutrition. J Investig Med High Impact Case Rep. 2023;11:23247096231168111. doi:10.1177/23247096231168111

Likely Very Effective

Based on 2 Researches

Vitamin B deficiency leads to rash

We explored the effects of riboflavin and biotin deficiencies in premature twins, who initially presented with skin rashes among other severe symptoms. After being diagnosed, one twin began supplementation with these vitamins.

Remarkably, this led to a quick improvement in clinical condition and laboratory findings within days. Though one twin experienced tragic complications resulting in death, the surviving twin went home in stable condition, highlighting the importance of addressing vitamin deficiencies early.

Improved skin condition

Most Useful Review

205 people found this helpful

There is no drowsiness after taking it, a very mild effect. After about two to three days of taking it, my sleep improved; I stopped waking up during the night. My skin condition has improved – no rashes, and I feel more fresh and radiant. It's the best value for money. I recommend it!

Sciatica details

After eating Zuo for a month, the sciatica pain seems to have lessened.

Sleep Apnea details

Improved sleep quality

269 people found this helpful

After taking this for 2-3 days, my sleep improved, and I stopped waking during the night. My skin condition also improved. I appreciate the inclusion of all B vitamins and Choline, which aids the absorption of uridine. I've been using it for two months, and I'm very pleased!

Stroke details

Zhang N, Wu Z, Bai X, Song Y, Li P, et al. Dosage exploration of combined B-vitamin supplementation in stroke prevention: a meta-analysis and systematic review. Am J Clin Nutr. 2024;119:821. doi:10.1016/j.ajcnut.2023.12.021

Based on 9 Researches

B-vitamins may reduce stroke risk

We investigated the impact of combined B-vitamin supplementation—specifically folic acid, vitamin B12, and vitamin B6—on stroke prevention. Through a thorough analysis of 14 randomized controlled trials, we found that these vitamins significantly reduced stroke risk, especially in areas lacking folic acid fortification.

Dosages below 0.8 mg/day for folic acid and 0.4 mg/day for vitamin B12 appeared to be the most effective. However, no benefits were seen in areas where fortification was already implemented. This suggests that while B vitamins can be beneficial, their effectiveness relies heavily on dietary conditions.

Effective vitamin solution

Most Useful Review

2 people found this helpful

An excellent complex of B vitamins; I purchased it for my mother, who experiences constant cramps in her legs and arms following a stroke. It became clear that these vital vitamins are beneficial for her condition. This complex truly presents an excellent solution to our problem, and the vitamins have positively impacted her.

Tinnitus details

Recommended for tinnitus

I purchased this for my father, who suffers from tinnitus, having been recommended by the doctor.

Anxiety details

Niacin helps alleviate anxiety symptoms

Samad N, Hameed A, Manzoor N, Shoukat S, Irfan A, et al. Antioxidant and neuro-modulatory effects of niacin prevent D-galactose-induced behavioral deficits and memory impairment. Exp Gerontol. 2024;198:112624. doi:10.1016/j.exger.2024.112624

We examined the impact of Niacin on anxiety and memory loss caused by aging in a rat study. Rats were grouped and treated with various doses of Niacin and D-galactose for 14 days, followed by behavioral tests to assess anxiety and memory.

Our results showed that Niacin significantly reduced anxiety-like symptoms and improved memory deficits. Additionally, it mitigated factors like oxidative stress and inflammation, enhancing brain health. Overall, Niacin's antioxidant and neuro-modulatory properties suggest it may be beneficial in addressing aging-related psychiatric issues.

Reduced anxiety

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23 people found this helpful

Essential nutrients! I purchased two bottles of this after not using it for three years. Since then, my lightheadedness, palpitations, and anxiety have vanished. I've realised that food alone can't provide all the nutrients I need. Thanks to Dr Fujikawa for this health method and to iHerb for selling this wonderful supplement not available in Japan.

Bruise details

Improved skin condition

The reality exceeded my expectations! After 2-3 weeks, the skin on my hands improved significantly! Before that, I had been purchasing medicinal creams for two years with little help. My sleep and thermoregulation improved! The condition of my skin throughout my body has enhanced; my legs feel smoother and more elastic. I noticed a decrease in puffiness and bruising under my eyes. I'm extremely pleased!

Depression details

Vitamin B may alleviate depression symptoms

Based on 12 Researches

Chen J, Liu J, Zhang P, Zhang S. [Effects of Vitamin B on Behaviors, Brain Monoamine Neurotransmitters, and Brain-Derived Neurotrophic Factor in Depressive Rats]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2025;56:206. doi:10.12182/20250160608

Our investigation looked into how Vitamin B affects behavior and neurotransmitter levels in rats undergoing stress-induced depression.

We set up three groups: a control group, a stressed group, and a stressed group receiving Vitamin B.

The results showed that Vitamin B improved neurotransmitter levels and reduced anxiety and depression-like behaviors in the rats. This suggests that Vitamin B could be beneficial in improving symptoms of depression driven by stress.

Mood improvement

Most Useful Review

447 people found this helpful

The whole B-complex is contained in one capsule. I have noticed real results: Despite dreary, rainy weather, I feel cheerful. This year, the usual autumn depression has not affected me. I respond calmly to work stress, viewing it as part of life. My skin is managing well through the autumn-winter transition, free from dryness and tightness. My joints are also not causing issues.

High Cholesterol details

Niacin reduces cholesterol and oxidative stress

Based on 10 Researches

Hamoud S, Kaplan M, Meilin E, Hassan A, Torgovicky R, et al. Niacin administration significantly reduces oxidative stress in patients with hypercholesterolemia and low levels of high-density lipoprotein cholesterol. Am J Med Sci. 2013;345:195. doi:10.1097/MAJ.0b013e3182548c28

We examined how niacin (vitamin B3) impacts cholesterol levels and oxidative stress in patients with low HDL cholesterol. In this study, 17 participants with high cholesterol received niacin treatment over 12 weeks, while 8 healthy individuals served as controls.

The results were promising. We discovered a significant boost in HDL cholesterol and a drop in triglycerides among the patients. More importantly, niacin also reduced markers of oxidative stress, suggesting its benefits extend beyond just cholesterol management. However, CRP levels remained unchanged.

Cholesterol normalised

Most Useful Review

3 people found this helpful

I bought this product to reduce high cholesterol and homocysteine levels. Used alongside trimethylglycine, I’m pleased with the results; both levels have fallen to normal after years of struggle. I definitely recommend this product!

Knee Pain details

Niacin intake eases knee osteoarthritis pain

Based on 2 Researches

Zheng Z, Luo H, Xue Q. Association between niacin intake and knee osteoarthritis pain and function: a longitudinal cohort study. Clin Rheumatol. 2024;43:753. doi:10.1007/s10067-023-06860-w

We investigated how niacin intake impacts pain and function in individuals with knee osteoarthritis (OA).

Using data from the Osteoarthritis Initiative, we analyzed niacin consumption alongside pain and functional scores.

Our findings reveal a significant association between higher niacin intake and reduced knee pain, suggesting that boosting niacin levels might improve the quality of life for OA patients.

Notably, specific groups, including middle-aged individuals and women, experienced even greater benefits.

No knee pain

Most Useful Review

4 people found this helpful

The Fujikawa-style megavitamin has had a remarkable effect. Even after cycling 100km, I experience no knee pain, and I am pleasantly surprised by my ability to sleep for 5 to 7 hours. I purchased 100 tablets this time but plan to switch to 250 tablets in the future.

Neuropathy details

Vitamin B12 improves vision recovery

Based on 9 Researches

Lubega G, Lutaakome J, Kibirige M, Opoka D, Atukunda I, et al. Vitamin B12 deficiency presenting as progressive blindness in a 33-year-old HIV-positive female patient on Efavirenz-based regimen: case report. Pan Afr Med J. 2024;47:164. doi:10.11604/pamj.2024.47.164.43048

We explored the effects of vitamin B12 on a 33-year-old woman living with HIV, who faced severe vision loss due to optic neuritis, a rare outcome of vitamin B12 deficiency. Prior to this, she had battled significant peripheral neuropathy treated with vitamin B12 tablets. After starting vitamin B12 injections following her vision loss, she experienced gradual improvement and regained her sight. This case highlights the importance of recognizing vitamin B12 deficiency, particularly since its signs can easily go unnoticed.

Nerve support

Most Useful Review

I am very impressed with B-50. I've noticed significant support for my nervous system, especially an improvement in the neuropathy in my feet. The quality from NOW is exceptional, and I felt the effects of B-50 entering my system quickly.

Psoriasis details

2 people found this helpful

I recommend these vitamins to anyone with health issues, especially those prone to skin diseases like psoriasis. After just one course (one can), my skin cleared up almost completely, and I am now ordering again. Highly recommended!

Blurred Vision details

Improved vision noted

This complex has significantly aided in restoring my nervous system following shingles. I experienced a side effect of enhanced cerebral circulation, clearer vision, and improved sleep.

Cancer details

Helps during treatment

My mother uses this for her therapy and finds it helpful, particularly as she experiences fatigue during chemotherapy and radiotherapy. Cancer patients undergoing these treatments are susceptible to oral ulcers, and I've heard that B vitamins can be beneficial in alleviating some of these issues!

Chronic Fatigue Syndrome details

B12 and folic acid show variability

Regland B, Forsmark S, Halaouate L, Matousek M, Peilot B, et al. Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia. PLoS One. 2015;10:e0124648. doi:10.1371/journal.pone.0124648

We examined the effects of vitamin B12 injections, combined with folic acid, on 38 patients with myalgic encephalomyelitis (ME), also known as chronic fatigue syndrome.

Participants were split into "Good" and "Mild" responders based on their improvement. Good responders reported greater progress with more frequent injections and higher doses of both supplements.

However, for Mild responders, the improvement was limited, suggesting that while there is potential for benefit, the response can vary widely among individuals. Overall, further investigation is needed to explore optimal treatment strategies.

Increased strength

Most Useful Review

247 people found this helpful

I was intrigued by the complex of B vitamins and opted for Now Foods B-50 as it offers excellent value. After just two days, I felt energetic and not fatigued, which is remarkable during the current illness season. I can complete my work and enjoy life again. I'm happy to recommend it.

Premenstrual Syndrome details

Less melancholy pre-period

8 people found this helpful

This vitamin B has alleviated my PMDD symptoms! Previously, I struggled with considerable pain and melancholy before my period, but since taking this, I have fewer episodes of irritability and am much calmer. It has made a noticeable difference, and I certainly plan to repurchase it!

Reflux details

The product contains the necessary B vitamins. I didn't experience any adverse reactions while taking this B complex alongside other supplements such as vitamin C with rose hips, D3, and ashwagandha. There was no acid reflux, and I feel less susceptible to muscle and nerve pains that people my age usually experience.

Adrenal Gland Disorder details

22 people found this helpful

MY FAVOURITE NERVE SOCIAL COMPLEX! PLEASE SUPPLY "YES" 💜 During stressful times, it is essential to increase B vitamin intake, as they are water-soluble and do not store in the body, making it crucial to maintain their optimal levels. This B vitamin complex is specifically designed to support the adrenal glands and manage stress! By the third day of usage, I noticed changes in my emotional state! My irritability decreased, anxiety vanished, and mood swings disappeared! Be healthy!

Anemia details

Di Sario F, Piloni F, Gasparini F, Serpetti E, Bruschi B, et al. Severe pancytopenia at the presentation of Imerslund-Gräsbeck syndrome in a 23-month-old Italian boy. Ital J Pediatr. 2024;50:186. doi:10.1186/s13052-024-01759-x

Based on 11 Researches

Case study: Vitamin B12 efficacy

We explored the case of a 23-month-old boy diagnosed with Imerslund-Gräsbeck syndrome (IGS), a rare disorder causing severe anemia. This child showed significant blood cell reduction and poor growth, which led to investigations identifying two genetic variants linked to his condition.

Remarkably, vitamin B12 replacement therapy resulted in a strong recovery. This case highlights how vital it is to diagnose IGS early in cases of severe anemia, ensuring timely treatment to avoid long-term complications, including potential neurological damage.

Safe dosage

Most Useful Review

16 people found this helpful

An excellent B-vitamin complex! Many supplements contain high dosages, which may be harmful. I suggest taking one capsule daily. B vitamins are vital for the nervous system and help with energy metabolism, reducing stress, and combating anemia. Highly recommend this complex!

Heartburn details

No heartburn observed

The quality of this complex is normal. While it may not be the best, it is acceptable given the price. I found that this complex did not cause any heartburn.

Liver Disease details

Methylcobalamin protects against liver failure

Based on 4 Researches

Xu W, Wang Y, Cui S, Zheng Q, Lin Y, et al. Methylcobalamin protects against liver failure via engaging gasdermin E. Nat Commun. 2025;16:1233. doi:10.1038/s41467-024-54826-6

We investigated how methylcobalamin, a form of vitamin B12, affects liver failure, particularly in cases of cholestasis. Methylcobalamin showed promise as it directly binds to and inhibits Gasdermin E, a protein linked to liver cell death.

In mouse models, this vitamin significantly reduced liver inflammation and damage, lowering mortality rates. These findings suggest that methylcobalamin could be a potential treatment option for preventing severe liver failure and related health issues.

Normal liver function

Most Useful Review

7 people found this helpful

Since my liver function exceeded the limit, I’ve taken this supplement with Milk Thistle for half a year. My liver values have normalised despite daily alcohol consumption, which was alarming but I aim to persist in taking it.

Back Pain details

Vitamin B12 effectively reduces pain

Based on 14 Researches

Mauro GL, Martorana U, Cataldo P, Brancato G, Letizia G. Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study. Eur Rev Med Pharmacol Sci. 2000;4:53.

We sought to understand how intramuscular vitamin B12 could help alleviate low back pain in patients with mechanical lumbago. In a rigorous study involving 60 participants, we compared the effects of vitamin B12 to a placebo.

Our findings indicated that those receiving the vitamin reported significantly less pain and disability, as measured by a visual scale and disability questionnaire. Notably, those on vitamin B12 also used less paracetamol than the placebo group.

Overall, our study confirmed that vitamin B12 can be effective for treating low back pain without nutritional deficiency.

Quick back relief

Most Useful Review

2 people found this helpful

It works remarkably well! After straining my back, I was gifted this supplement. I expected recovery to take a month, but within days I resumed normal life, with the discomfort nearly gone in a week.

Weight Loss details

Yanni AE, Kokkinos A, Psychogiou G, Binou P, Kartsioti K, et al. Daily consumption of fruit-flavored yoghurt enriched with vitamins B contributes to lower energy intake and body weight reduction, in type 2 diabetic patients: a randomized clinical trial. Food Funct. 2019;10:7435. doi:10.1039/c9fo01796h

Based on 3 Researches

USERS' SCORE

Good

Based on 19 Reviews

Vitamin B yogurt aids weight loss

We investigated whether yogurt enriched with B vitamins could help with weight management in overweight patients with Type 2 Diabetes. Over 12 weeks, participants consumed either vitamin-enriched yogurt or conventional yogurt daily.

Those in the enriched group experienced a significant reduction in body weight and calorie intake compared to those who consumed regular yogurt. While overall improvements in glycemic control were less prominent, vitamin levels in the body did improve.

This suggests that vitamin B-rich yogurt can play a beneficial role in weight management and nutrient status for people with Type 2 Diabetes.

7.5

Effective for dieting

Most Useful Review

57 people found this helpful

I recommend this for dieting and boosting fat burning. Since I started taking B vitamins, my weight loss has resumed, and my body feels less sluggish. My urine has turned yellow, indicating it's working. This supplement is one I intend to keep using.

Adenoiditis details

Effective throat support

1 people found this helpful

I purchased it for myself and have always relied on it. Previously, I used to take it in the form of picolinate, but this time I opted for these lozenges and have not regretted it. They have a pleasant taste and soften the throat upon absorption. I take it every two hours when I notice a sore throat, and it greatly alleviates the discomfort. I highly recommend it!

Bone Pain details

Carnitine aids bone pain relief

Tabei SM, Mazloom M, Shahriari M, Zareifar S, Azimi A, et al. Determining and surveying the role of carnitine and folic acid to decrease fatigue in β-thalassemia minor subjects. Pediatr Hematol Oncol. 2013;30:742. doi:10.3109/08880018.2013.771388

We examined the potential benefits of carnitine and folic acid in reducing bone pain and fatigue in patients with beta-thalassemia minor. Over three months, 73 participants received either carnitine alone, a combination of carnitine and folic acid, or folic acid alone, while a control group went without supplementation.

Our results showed that carnitine significantly improved plasma levels and reduced bone pain and muscle weakness for those affected by this condition. Although folic acid improved red blood cell levels, its impact on bone pain was not directly highlighted. Overall, our findings suggest that carnitine can be beneficial in addressing bone pain in these patients.

Improved sleep quality

Most Useful Review

28 people found this helpful

Excellent for vegetative vascular issues. Since starting, I’ve experienced fewer exacerbations and the headaches have diminished significantly. After a couple of weeks, the constant fatigue has lessened. Now, 7 hours of sleep at night suffices, and I no longer feel the need to nap in the afternoon.

Menopause details

Cho KA, Kim YH, Woo SY, Ryu KH. Tonsil-Derived Mesenchymal Stem Cell-Derived Small Extracellular Vesicles (sEVs) Restore Myo-Inositol Production in LPS-Treated Skeletal Muscle. Tissue Eng Regen Med. 2025. doi:10.1007/s13770-025-00709-w

Based on 8 Researches

Investigating T-MSCs for menopause

We investigated if small extracellular vesicles (sEVs) derived from tonsil stem cells could improve myo-inositol production, which is often disrupted by inflammation in menopausal women.

Over two weeks, mice received treatments mimicking this condition. Our results indicated that those receiving sEVs showed a restoration of myo-inositol levels and healthier muscle profiles compared to those that did not.

This research suggests that sEVs could be a promising option to improve metabolic health during menopause.

Weight management

Most Useful Review

1 people found this helpful

I've been taking this for six months, with one tablet in the morning and one in the afternoon. I believe my weight is stabilising, and my cholesterol levels have normalised at my latest health check. This product may help with menopause symptoms, and it complements other supplements well.

Migraine details

Vitamin B2 significantly reduces migraines

Based on 15 Researches

Chen YS, Lee HF, Tsai CH, Hsu YY, Fang CJ, et al. Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis. Nutr Neurosci. 2022;25:1801. doi:10.1080/1028415X.2021.1904542

In our review and meta-analysis, we sought to understand how Vitamin B2 supplementation influences migraines. By examining nine studies with over 670 participants, we found that taking 400 mg of Vitamin B2 daily for three months significantly reduced the frequency, duration, and pain intensity of migraine attacks.

Our analysis revealed that Vitamin B2 wasn't just a minor help; it truly made a difference in managing migraine symptoms. This suggests a potential alternative to traditional pharmaceuticals, offering hope for migraine sufferers looking for effective prevention options.

Effective migraine remedy

Most Useful Review

3 people found this helpful

STOP THE MIGRAINES. Four of my family members use this vitamin to ward off migraines or stop them at the first sign. Caffeine, cow's milk products, and real chocolate trigger my migraines. Extreme stress exacerbates them. This yeast-based B-50 vitamin builds resistance to symptoms (bright lights, vertigo, head pain, nausea) and taken at the onset will halt a migraine immediately. The prescribed dosage for my family is 2 capsules with each of the 3 meals, adjusting by reducing the evening dose to 1 and the lunch dose as needed while keeping breakfast at 2. Each of us has a slightly different response, but we take 5-6 capsules when a migraine sneaks in. It reduces the prolonged fatigue that can ruin a day.

Dizziness details

Gabapentin and B vitamins reduce dizziness

Mimenza Alvarado A, Aguilar Navarro S. Clinical Trial Assessing the Efficacy of Gabapentin Plus B Complex (B1/B12) versus Pregabalin for Treating Painful Diabetic Neuropathy. J Diabetes Res. 2016;2016:4078695. doi:10.1155/2016/4078695

We evaluated the effects of gabapentin combined with B vitamins (B1 and B12) against pregabalin for painful diabetic neuropathy. In this multicenter, randomized, and blind study, 270 patients participated over 12 weeks.

Both treatments reduced pain without a significant statistical difference. However, our findings indicated that the gabapentin plus B vitamin group experienced fewer cases of dizziness, highlighting a potential advantage in managing side effects compared to pregabalin. This could lead to a more comfortable treatment experience for patients.

7.5

Pressure improvement

Most Useful Review

169 people found this helpful

A comprehensive B vitamin complex. Don't worry about the high daily dosage; these vitamins are water-soluble and flush out excess quickly. I've struggled with pressure drops causing dizziness. After a couple of weeks of taking this supplement, I've noticed improvements, and my blood pressure has returned to normal.

Hair Loss details

Cicaria shows promise against hair loss

Jo H, Kim SY, Kang BH, Baek C, Kwon JE, et al. Cicaria, a Novel Strain Derived from the Human Microbiome, and Its Efficacy as a Treatment for Hair Loss. Molecules. 2022;27. doi:10.3390/molecules27165136

We examined a new strain derived from the human microbiome, Cicaria, to see how it helps with hair loss. Through testing on individuals with hair loss and comparing them to a control group with normal scalps, we found that Cicaria produced key compounds like adenosine and biotin. Notably, hair follicles treated with these elements displayed longer lengths and maintained healthier root diameters. Furthermore, these treatments appeared to support the phases of hair growth, slowing the transition to hair loss. Thus, Cicaria shows potential as a treatment for hair loss.

7.5

Reduced hair loss

Most Useful Review

8 people found this helpful

As a 36-year-old male, I've noticed that my vertically open pores have shrunk and my skin tone has improved. Less hair is falling out; there’s notably less hair loss on my pillow each morning. Most importantly, my fatigue doesn’t persist into the next day. Vitamin B has become essential for me.

Hypertension details

Protects against hypertension

Vitamin B plays a crucial role in our lives; it helps protect the body against hypertension, insomnia, and cardiovascular diseases. The B-50 from Now is of high quality, and I recommend it.

Insomnia details

Ohta T, Ando K, Iwata T, Ozaki N, Kayukawa Y, et al. Treatment of persistent sleep-wake schedule disorders in adolescents with methylcobalamin (vitamin B12). Sleep. 1991;14:414.

Vitamin B12 aids sleep disorders

We observed two adolescents struggling with severe sleep-wake schedule disorders respond positively to high doses of vitamin B12, specifically methylcobalamin. The 15-year-old girl with delayed sleep phase syndrome and the 17-year-old boy with hypernychthemeral syndrome showed immediate improvements after receiving 3,000 micrograms per day.

Notably, there was no evidence of vitamin B12 deficiency in either case, as their levels remained in the normal range. The girl's sleep duration reduced from 10 hours to 7 hours, while the onset of her sleep moved from 2 a.m. to midnight. The boy's sleep-wake cycle also adjusted slightly, indicating potential benefits of methylcobalamin for these disorders.

Improvements noted

Most Useful Review

4 people found this helpful

B vitamins are vital for the body. Their deficiency can lead to insomnia and other issues. Since taking this supplement, I've noticed improvements in my nervous system's functioning, helping reduce my insomnia. The quality and dosage are good, though high doses should be monitored.

Ulcer details

Benfotiamine improves ulcer healing

Shokati Sayyad M, Khanjani MH, Amirbeik M, Seyedabadi M, Talebpour Amiri F, et al. The protective effect of benfotiamine on gastric ulcers in male rats: an experimental study. J Mol Histol. 2024;55:863. doi:10.1007/s10735-024-10237-x

We investigated how benfotiamine might impact stomach ulcers in male rats. The study involved dividing 30 rats into groups receiving different treatments, including benfotiamine at varying doses, following the induction of ulcers using indomethacin.

Our results showed that benfotiamine notably decreased gastric damage and lowered inflammation markers. Specifically, doses of 100 and 200 mg/kg appeared to enhance antioxidant levels and reduce tissue damage.

However, while these findings are promising, more research is needed to fully understand the mechanisms at play and assess benfotiamine's potential for human treatment.

Eliminated mouth ulcers

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7 people found this helpful

I can effectively absorb B vitamins now. I used to take several B vitamins daily, which was inconvenient, but switching to Vitamin B-50 has been a game-changer. I take one tablet in the morning and evening, and since then, I've stopped getting mouth ulcers. I love taking it in the morning for an energy boost, and despite its size, it’s not an issue. The excellent cost performance means I will continue buying it.

Acne details

Panthenol mask improves skin barrier

Likely Very Effective

Zhang X, Tao H, Deng Y, He X, Zhang Z, et al. Efficacy and safety of a panthenol-enriched mask for individuals with distinct impaired skin barrier subtypes. J Cosmet Dermatol. 2024;23:2109. doi:10.1111/jocd.16231

We aimed to evaluate how a panthenol-enriched mask, specifically La Roche-Posay Mask Pro, performs in improving skin barriers for different types, such as dry sensitive, oily sensitive, and oily acne-prone skin.

Over 177 participants used the mask under guidance, and we measured factors like hydration, sebum content, and redness at multiple intervals.

The results showed significant improvements across all skin types, particularly for oily acne skin, which saw reductions in sebum and redness. Importantly, there were no adverse effects reported, indicating that this mask can be a trusty companion for those with various skin concerns.

Improved complexion

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44 people found this helpful

I discovered I had a vitamin deficiency. I usually prefer meat and rice and neglect vegetables. In my 40s, this neglect showed on my face. To combat it, I began taking vitamins B and C in the morning and evening, as well as A and E at night. My complexion improved, with no acne and smaller pores. I felt rejuvenated. It’s clear that internal changes are essential for real improvement.

Bacterial Infection details

The B50 Complex boosts immunity, energy, and nervous system function, which is beneficial for sinusitis and other infections. It aids recovery by speeding up healing and reducing inflammation, especially when paired with vitamin C and magnesium.

Common Cold details

Zinc reduces diarrhea, colds in infants

Likely Very Effective

McDonald CM, Manji KP, Kisenge R, Aboud S, Spiegelman D, et al. Daily Zinc but Not Multivitamin Supplementation Reduces Diarrhea and Upper Respiratory Infections in Tanzanian Infants: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. J Nutr. 2015;145:2153. doi:10.3945/jn.115.212308

We investigated the impact of daily multivitamin and zinc supplementation on the health of Tanzanian infants. In our randomized, double-blind study involving 2,400 infants, we compared the effects of these supplements against a placebo over 18 months.

Our findings revealed that while zinc significantly reduced occurrences of diarrhea and acute respiratory infections, multivitamins did not provide additional benefits. Ultimately, zinc supplementation starting at 6 weeks may be beneficial for reducing some common illnesses in infants, but multivitamins did not show any significant positive impact.

No more colds

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8 people found this helpful

B vitamins are water-soluble, so I take them daily to ensure I’m replenished. Since I started, I no longer catch the common cold or get canker sores!

Heart Disease details

Herpes symptoms eliminated

VB6 helps heart recovery post-AMI

We explored how vitamin B6 (VB6) supports heart recovery post-heart attack. In our study, we found that VB6 encourages angiogenesis, which is crucial for healing. Through experiments, we noticed that VB6 helps in cell migration and blood vessel formation by activating a specific protein that plays a key role in these processes. Additionally, long-term use of VB6 improved heart function in mice. While these findings are promising, it’s important to note that further research is necessary to fully understand VB6's effects in humans.

7.5

Normalised blood pressure

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189 people found this helpful

This is a wonderful complex of B vitamins. After a month, my leg pains disappeared and the sensitivity in my fingers and toes was restored. I recommend taking it with magnesium for therapeutic purposes; it really helps with heart disease and stress-related issues. I even used it during pregnancy for high blood pressure, and it worked perfectly.

Herpes details

I took it consistently and found it to be an excellent remedy. Although I experienced daily herpes outbreaks for a month, it completely disappeared and has not returned for six months. I believe this product has helped eliminate the herpes from my system.

Swollen Lymph Nodes details

Proven manufacturer! I take these vitamins on my doctor's recommendation, and the results are evident. After a severe bruise to my coccyx, I experienced intense pain; however, the swelling was alleviated, though the aching pain occasionally returned. With my sedentary job causing issues with my back, elbow, and shoulder, I can now confidently say that following the vitamin regimen led me to forget about the pain altogether. After suffering for four years, the intermittent and acute pains have disappeared for good! 😊😊😊

Headache details

Pediatric migraine treatment with riboflavin

Based on 15 Researches

Das R, Qubty W. Retrospective Observational Study on Riboflavin Prophylaxis in Child and Adolescent Migraine. Pediatr Neurol. 2021;114:5. doi:10.1016/j.pediatrneurol.2020.09.009

Our examination focused on the effectiveness of riboflavin, a form of Vitamin B2, in treating migraines in children and adolescents aged six to 18. We conducted a retrospective observational study involving 42 patients, where we measured the frequency, intensity, and duration of their headaches.

Remarkably, we found significant reductions in headache days per month, with intensity and duration also decreasing. Most importantly, riboflavin helped decrease the reliance on acute medication and fewer missed school days. We suggest this affordable treatment as a safe option for pediatric migraines.

Clearer thoughts

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212 people found this helpful

I have been taking 1 capsule each morning for a month, and my brain and body have become more active. I now experience easy awakenings and increased cheerfulness throughout the day, along with improved clarity of thoughts and memory. Headaches have disappeared, leaving me with a desire for creative activities. My stamina during gym sessions has also increased. I definitely recommend it!

Kidney Stones details

Kidney disease prevention

The B-50 I took after eating resulted in yellow-green urine, indicating an excess dose being excreted. Vitamin B6 (pyridoxine) is vital for preventing kidney stones and improving the absorption of proteins and fats. Overall, these vitamins have been beneficial in providing various health advantages, including bolstering my immunity and improving my well-being.

Irritable Bowel Syndrome details

Good vitamins. The coronavirus greatly affected my nervous system, but thanks to these vitamins, I've become less irritable and sleep better. My hair problems and hair loss have decreased. 🤓👍

Chest Pain details

Vitamin B complex's minor impact on health

Martí-Carvajal AJ, Solà I, Lathyris D, Dayer M. Homocysteine-lowering interventions for preventing cardiovascular events. Cochrane Database Syst Rev. 2017;8:CD006612. doi:10.1002/14651858.CD006612.pub5

We evaluated the effects of vitamin B complex supplements on chest pain and heart health by reviewing 15 studies involving over 71,000 participants.

Our investigation revealed that while there were no significant differences in rates of heart attacks, overall deaths, or serious side effects between those receiving vitamin B complex and placebo, there was a slight reduction in stroke incidence.

However, the benefits were minimal and outcomes varied with dosages, indicating that more research is needed to draw firm conclusions about the effectiveness of these vitamin interventions on cardiovascular events.

Chest pain relief

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1 people found this helpful

I highly recommend the Vitamin B-50 supplement! It’s superb and has boosted my energy significantly. I no longer experience chest pain when anxious—a major concern for me.

Cold details

8 people found this helpful

B vitamins are water-soluble, and except for B-12, the amount stored in the body is limited, so I’ve learned to replenish them daily! What I’ve noticed is effective; I no longer catch a cold or suffer from canker sores.

Gastritis details

Boosts work performance

I’m uncertain how it works, but these vitamins certainly provide me with energy. I don’t take them regularly, only during busy periods—like December’s year-end rush—when they help considerably with my work capacity. I always take them in the morning with meals, as taking them after dinner makes it difficult for me to sleep. However, with prolonged use, my gastrointestinal tract tends to react, and I experience pain akin to gastritis. Additionally, my urine turns a bright colour! Overall, during high mental workload periods, these vitamins are my lifesaver.

Allergies details

Pinitol may reduce allergy symptoms

You X, Sun X, Kong J, Tian J, Shi Y, et al. D-Pinitol Attenuated Ovalbumin-induced Allergic Rhinitis in Experimental Mice via Balancing Th1/Th2 Response. Iran J Allergy Asthma Immunol. 2021;20:672. doi:10.18502/ijaai.v20i6.8017

We evaluated how D-Pinitol affects allergic rhinitis (AR) in a controlled study using mice.

By sensitizing BALB/c mice with ovalbumin (OVA), we created an AR model. After giving treatment groups various doses of pinitol or montelukast, we found that higher doses of pinitol significantly reduced symptoms like sneezing and nasal discharge.

Notably, it also balanced specific immune responses typically seen in allergies. However, montelukast showed clearer results in some areas, indicating that while pinitol is promising, more research is necessary.

Improved atopic dermatitis

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1 people found this helpful

I began taking this B complex daily, and after a month, my atopic dermatitis, itching, and dry skin have improved significantly. Although I take additional vitamins too, I believe this B complex is the most effective.

Blood Clot details

Tu YR, Tu KH, Lee CC, Fan PC, Yen CL, et al. Supplementation with Folic Acid and Cardiovascular Outcomes in End-Stage Kidney Disease: A Multi-Institution Cohort Study. Nutrients. 2022;14. doi:10.3390/nu14194162

Based on 6 Researches

Folic acid reduces clot events

We examined the effects of folic acid supplementation on blood clot events in patients with end-stage kidney disease (ESKD). Analyzing data from over 2,000 patients, we divided them into daily and weekly supplementation groups for a mean follow-up of 5.8 years.

Our findings indicated that patients receiving daily folic acid had a lower rate of arteriovenous access thrombosis compared to those on a weekly regimen. However, we found no significant differences between the groups concerning major cardiovascular events or overall mortality.

More research is needed to fully understand the potential of folate in preventing thrombosis in this population.

7.5

Cardiovascular protection

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33 people found this helpful

Works well and aids in combating homocysteine. I've taken the second can of this complex with no side effects, and the positive effects are clear. B12 and folic acid are vital for lowering homocysteine, which can lead to blood clots. It serves as a good preventative measure for cardiovascular diseases when combined with Omega-3.

Autoimmune Disorder details

Mswelo VE, David MM, Banturaki A, Munyambalu DK, Hassan HA, et al. Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report. J Med Case Rep. 2025;19:60. doi:10.1186/s13256-025-05095-4

Pernicious anemia case in Uganda

We focused on a case of pernicious anemia in a 51-year-old Ugandan man who presented with recurring lower limb weakness. After initial treatment for vitamin B12 deficiency years ago and further testing, we confirmed his diagnosis of pernicious anemia marked by low cobalamin levels. Thanks to timely parenteral methylcobalamin therapy, he showed improvement. This case underscores the importance of recognizing vitamin B12 deficiency, especially in rural and resource-limited settings, to address neurological symptoms quickly.

Stable remission achieved

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20 people found this helpful

Excellent! I constantly order this drug. After my diagnosis of autoimmune disorder in 2011, I struggled with my quality of life. I realised that normalising my metabolic processes and reducing infections were key. I take B-50 in short courses and at the first sign of respiratory illnesses, which has proven effective. Unlike other brands, B-50 from Now Foods has become my main choice due to its significant benefits.

Diarrhea details

This product is easy to absorb and doesn’t cause adverse reactions. Previously, the oral liquid iron supplements I tried, including one from Germany, led to diarrhoea, but this one does not. It is highly effective!

Flu details

Physical condition improved

4 people found this helpful

I take this supplement twice a day, and it’s quite easy to drink. The smell doesn’t bother me. I combine it with protein and other supplements, and I'm feeling very well! I managed to purchase it at a lower price than other sites. It contains folic acid, which is beneficial for women. No niacin flush experienced, even with additional niacin in the evening. We will keep prioritising our health!

Nausea details