5/23/2025
Last update
5/23/2025
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.3
USERS' SCORE
Good
Based on 36 Reviews
8.3
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Thiamin (Vitamin B-1) (from Thiamin HCl)
50 mg
4167%
Riboflavin (Vitamin B-2)
50 mg
3846%
Niacin (Vitamin B-3) (as Niacinamide)
50 mg
313%
Vitamin B-6 (from Pyridoxine HCl)
50 mg
2941%
Folate
680 mcg DFE (400 mcg folic acid)
170%
Vitamin B-12 (as Cyanocobalamin)
50 mcg
2083%
Biotin
50 mcg
167%
Pantothenic Acid (from Calcium Pantothenate)
50 mg
1000%
Choline (from Choline Bitartrate)
25 mg
5%
PABA (Para-Aminobenzoic Acid)
25 mg
†
Inositol
25 mg
†
Top Medical Research Studies
8
We examined the impact of Niacin on anxiety and memory loss caused by aging in a rat study. Rats were grouped and treated with various doses of Niacin and D-galactose for 14 days, followed by behavioral tests to assess anxiety and memory.
Our results showed that Niacin significantly reduced anxiety-like symptoms and improved memory deficits. Additionally, it mitigated factors like oxidative stress and inflammation, enhancing brain health. Overall, Niacin's antioxidant and neuro-modulatory properties suggest it may be beneficial in addressing aging-related psychiatric issues.
Our results showed that Niacin significantly reduced anxiety-like symptoms and improved memory deficits. Additionally, it mitigated factors like oxidative stress and inflammation, enhancing brain health. Overall, Niacin's antioxidant and neuro-modulatory properties suggest it may be beneficial in addressing aging-related psychiatric issues.
Read More
We explored how vitamin B could help fight anxiety and depression linked to nicotine withdrawal in young male rats.
The study involved giving some rats nicotine before dividing them into different groups, where some were treated with vitamin B and others with bupropion—a common anxiety medication.
The results were promising, with vitamin B showing potential in reducing anxiety symptoms, comparable to bupropion. This opens the door for vitamin B as a possible new treatment option for various anxiety-related issues.
The study involved giving some rats nicotine before dividing them into different groups, where some were treated with vitamin B and others with bupropion—a common anxiety medication.
The results were promising, with vitamin B showing potential in reducing anxiety symptoms, comparable to bupropion. This opens the door for vitamin B as a possible new treatment option for various anxiety-related issues.
Read More
7
We investigated how Vitamin B can affect anxiety and depression in a rat model facing chronic stress. Seventy-two rats were divided into three groups: a control group, a stressed group, and a stressed group receiving Vitamin B injections.
The study measured behavioral changes and key neurotransmitter levels. Results showed that Vitamin B helped restore neurotransmitter levels and improved the rats' behavior. This suggests that Vitamin B could potentially play a role in alleviating anxiety and depressive symptoms by supporting brain health.
The study measured behavioral changes and key neurotransmitter levels. Results showed that Vitamin B helped restore neurotransmitter levels and improved the rats' behavior. This suggests that Vitamin B could potentially play a role in alleviating anxiety and depressive symptoms by supporting brain health.
Read More
Most Useful Reviews
9
Reduced anxiety
23 people found this helpful
Essential nutrients! I purchased two bottles of this after not using it for three years. Since then, my lightheadedness, palpitations, and anxiety have vanished. I've realised that food alone can't provide all the nutrients I need. Thanks to Dr Fujikawa for this health method and to iHerb for selling this wonderful supplement not available in Japan.
Read More
9
Improved well-being
22 people found this helpful
MY FAVOURITE NERVE SOCIAL COMPLEX! During stressful times, B vitamins are crucial as they don't accumulate in the body. This B complex is designed to support the adrenal glands and manage stress. I noticed an improvement by day three—my irritability and anxiety reduced significantly!
Read More
9
Stress management
6 people found this helpful
This B vitamin complex is excellent, with B-1, B-2, B-3, B-6, B-12, Biotin, Choline, Inositol, and Pantothenic Acid. It's specifically for adrenal support and managing stress. After a few days, I noticed my irritability, anxiety, and mood swings improved.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.3
- All Researches
8
We examined the impact of Niacin on anxiety and memory loss caused by aging in a rat study. Rats were grouped and treated with various doses of Niacin and D-galactose for 14 days, followed by behavioral tests to assess anxiety and memory.
Our results showed that Niacin significantly reduced anxiety-like symptoms and improved memory deficits. Additionally, it mitigated factors like oxidative stress and inflammation, enhancing brain health. Overall, Niacin's antioxidant and neuro-modulatory properties suggest it may be beneficial in addressing aging-related psychiatric issues.
Our results showed that Niacin significantly reduced anxiety-like symptoms and improved memory deficits. Additionally, it mitigated factors like oxidative stress and inflammation, enhancing brain health. Overall, Niacin's antioxidant and neuro-modulatory properties suggest it may be beneficial in addressing aging-related psychiatric issues.
Read More
We explored how vitamin B could help fight anxiety and depression linked to nicotine withdrawal in young male rats.
The study involved giving some rats nicotine before dividing them into different groups, where some were treated with vitamin B and others with bupropion—a common anxiety medication.
The results were promising, with vitamin B showing potential in reducing anxiety symptoms, comparable to bupropion. This opens the door for vitamin B as a possible new treatment option for various anxiety-related issues.
The study involved giving some rats nicotine before dividing them into different groups, where some were treated with vitamin B and others with bupropion—a common anxiety medication.
The results were promising, with vitamin B showing potential in reducing anxiety symptoms, comparable to bupropion. This opens the door for vitamin B as a possible new treatment option for various anxiety-related issues.
Read More
7
We investigated how Vitamin B can affect anxiety and depression in a rat model facing chronic stress. Seventy-two rats were divided into three groups: a control group, a stressed group, and a stressed group receiving Vitamin B injections.
The study measured behavioral changes and key neurotransmitter levels. Results showed that Vitamin B helped restore neurotransmitter levels and improved the rats' behavior. This suggests that Vitamin B could potentially play a role in alleviating anxiety and depressive symptoms by supporting brain health.
The study measured behavioral changes and key neurotransmitter levels. Results showed that Vitamin B helped restore neurotransmitter levels and improved the rats' behavior. This suggests that Vitamin B could potentially play a role in alleviating anxiety and depressive symptoms by supporting brain health.
Read More
7
Vitamin B aids anxiety recovery
We explored the effects of vitamin B supplementation on anxiety and cognitive function in male Swiss albino mice following traumatic brain injury (TBI). Our research found that vitamin B appears to improve neurological impairments, enhance memory, and reduce anxiety-like behaviors.
Additionally, we saw a reduction in oxidative stress markers, indicating better neuronal health. This suggests that vitamin B not only helps with anxiety but also plays a role in recovery from cognitive dysfunctions associated with TBI.
Additionally, we saw a reduction in oxidative stress markers, indicating better neuronal health. This suggests that vitamin B not only helps with anxiety but also plays a role in recovery from cognitive dysfunctions associated with TBI.
Read More
We explored the effectiveness of vitamin B complex in treating anxiety among patients with Post-COVID-19 syndrome (PC19S) through the PreVitaCOV trial. This study involved 240 participants who were given either prednisolone, vitamin B1, B6, and B12, a combination of these treatments, or a placebo. While the trial showed high feasibility and safety, it ultimately did not demonstrate significant benefits in symptom change over placebo in anxiety or other evaluated symptoms.
Read More
User Reviews
USERS' SCORE
Good
Based on 36 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduced anxiety
23 people found this helpful
Essential nutrients! I purchased two bottles of this after not using it for three years. Since then, my lightheadedness, palpitations, and anxiety have vanished. I've realised that food alone can't provide all the nutrients I need. Thanks to Dr Fujikawa for this health method and to iHerb for selling this wonderful supplement not available in Japan.
Read More
9
Improved well-being
22 people found this helpful
MY FAVOURITE NERVE SOCIAL COMPLEX! During stressful times, B vitamins are crucial as they don't accumulate in the body. This B complex is designed to support the adrenal glands and manage stress. I noticed an improvement by day three—my irritability and anxiety reduced significantly!
Read More
9
Stress management
6 people found this helpful
This B vitamin complex is excellent, with B-1, B-2, B-3, B-6, B-12, Biotin, Choline, Inositol, and Pantothenic Acid. It's specifically for adrenal support and managing stress. After a few days, I noticed my irritability, anxiety, and mood swings improved.
Read More
9
Sleep improved
2 people found this helpful
This is the best B vitamin complex! I've felt much better; my insomnia has disappeared, and I can finally sleep. The anxiety that kept me awake has gone. I highly recommend it, especially for those on a keto diet!
Read More
9
Calmed anxiety
1 people found this helpful
A quality supplement, invaluable for neurology issues. Following the instructions, my irritability and anxiety have vanished.
Read More
Frequently Asked Questions
9
Improved well-being
22 people found this helpful
MY FAVOURITE NERVE SOCIAL COMPLEX! During stressful times, B vitamins are crucial as they don't accumulate in the body. This B complex is designed to support the adrenal glands and manage stress. I noticed an improvement by day three—my irritability and anxiety reduced significantly!
9
Stress management
6 people found this helpful
This B vitamin complex is excellent, with B-1, B-2, B-3, B-6, B-12, Biotin, Choline, Inositol, and Pantothenic Acid. It's specifically for adrenal support and managing stress. After a few days, I noticed my irritability, anxiety, and mood swings improved.
9
Emotionally stable
1 people found this helpful
Excellent Vitamins! Within a week, my emotional state improved, anxiety dissipated, and I stopped being irrationally nervous. My sleep quality has greatly improved!
7.5
Mental clarity
10 people found this helpful
I've started drinking these for fertility, fatigue recovery, and beautiful skin. After a month, my anxiety has faded—I've realised the importance of the B50 complex for energy metabolism. I'm excited to see the additional benefits, like preventing hair loss and dermatitis.
7.5
Less anxious
1 people found this helpful
Excellent! I've been taking these vitamins for over six months and the effect is remarkable. My anxiety has significantly reduced, and I feel calmer.
7.5
Anxiety improvement
2 people found this helpful
I've been taking this along with other vitamins for about a year. While I cannot isolate its effect, I've noticed an improvement in my anxiety symptoms since I began this regimen.
6
Convenient B vitamins
1 people found this helpful
As vegetarians, it can be challenging to obtain each B vitamin separately. Having B50 is convenient for us, as each type nourishes the nerves. Lack of B6 can contribute to anxiety, whereas B1 is beneficial for treating various conditions, including menstrual pain and short-term memory issues.
7.5
Boosted energy
4 people found this helpful
I've purchased these vitamins before. They helped reduce my anxiety and improve sleep. My doctor advised increasing my B vitamins to manage cortisol levels. I had noticeable results by day three. I recommend them for keeping the nervous system healthy.
7.5
Calms anxiety
4 people found this helpful
On the second day, my blood pressure dropped (100/60). It seems the dosage was high for me as I weigh only 45 kg. I’ll take it every other day now; it truly calms nerves and diminishes anxiety.
9
Anxiety management
I suffer from anxiety and panic disorder, so I take one tablet twice daily to combat fatigue. This supplement is essential for me, and the capsules are easy to swallow. I plan to repurchase once I run out.
7
We investigated how Vitamin B can affect anxiety and depression in a rat model facing chronic stress. Seventy-two rats were divided into three groups: a control group, a stressed group, and a stressed group receiving Vitamin B injections.
The study measured behavioral changes and key neurotransmitter levels. Results showed that Vitamin B helped restore neurotransmitter levels and improved the rats' behavior. This suggests that Vitamin B could potentially play a role in alleviating anxiety and depressive symptoms by supporting brain health.
The study measured behavioral changes and key neurotransmitter levels. Results showed that Vitamin B helped restore neurotransmitter levels and improved the rats' behavior. This suggests that Vitamin B could potentially play a role in alleviating anxiety and depressive symptoms by supporting brain health.
8
We examined the impact of Niacin on anxiety and memory loss caused by aging in a rat study. Rats were grouped and treated with various doses of Niacin and D-galactose for 14 days, followed by behavioral tests to assess anxiety and memory.
Our results showed that Niacin significantly reduced anxiety-like symptoms and improved memory deficits. Additionally, it mitigated factors like oxidative stress and inflammation, enhancing brain health. Overall, Niacin's antioxidant and neuro-modulatory properties suggest it may be beneficial in addressing aging-related psychiatric issues.
Our results showed that Niacin significantly reduced anxiety-like symptoms and improved memory deficits. Additionally, it mitigated factors like oxidative stress and inflammation, enhancing brain health. Overall, Niacin's antioxidant and neuro-modulatory properties suggest it may be beneficial in addressing aging-related psychiatric issues.
We explored the effectiveness of vitamin B complex in treating anxiety among patients with Post-COVID-19 syndrome (PC19S) through the PreVitaCOV trial. This study involved 240 participants who were given either prednisolone, vitamin B1, B6, and B12, a combination of these treatments, or a placebo. While the trial showed high feasibility and safety, it ultimately did not demonstrate significant benefits in symptom change over placebo in anxiety or other evaluated symptoms.
References
- Chen J, Liu J, Zhang P, Zhang S. [Effects of Vitamin B on Behaviors, Brain Monoamine Neurotransmitters, and Brain-Derived Neurotrophic Factor in Depressive Rats]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2025;56:206. 10.12182/20250160608
- Samad N, Hameed A, Manzoor N, Shoukat S, Irfan A, et al. Antioxidant and neuro-modulatory effects of niacin prevent D-galactose-induced behavioral deficits and memory impairment. Exp Gerontol. 2024;198:112624. 10.1016/j.exger.2024.112624
- Yadav P, Nasir F, Sivanandam TM. Neuroprotective effect of vitamin B supplementation on cognitive functions and neuronal morphology at different time intervals after traumatic brain injury in male Swiss albino mice. Neurochem Int. 2024;180:105869. 10.1016/j.neuint.2024.105869
- Tengelmann C, Joos S, Kaußner Y, Malzahn U, Lunden L, et al. Feasibility, safety and effectiveness of prednisolone and vitamin B1, B6, and B12 in patients with post-COVID-19-syndrome (PreVitaCOV) - protocol of a randomised, double-blind, placebo-controlled multicentre trial in primary care (phase IIIb). BMC Infect Dis. 2024;24:56. 10.1186/s12879-023-08925-2
- Pahlavani H, Masoudi M, Khoshroo N, Kakhki S, Mahdi Rezavanimehr M, et al. Vitamin B reversed anxiety and depression induced by adolescent nicotine withdrawal through alteration the inflammatory, oxidative and serotoninergic profiles in male rats. Biochem Pharmacol. 2023;217:115832. 10.1016/j.bcp.2023.115832
- Kakhki S, Goodarzi M, Abbaszade-Cheragheali A, Rajabi M, Masoumipour AH, et al. Folic acid supplementation improved cognitive deficits associated with lithium administration during pregnancy in rat offspring. Int J Dev Neurosci. 2023;83:615. 10.1002/jdn.10289
- Shemirani F, Titcomb TJ, Saxby SM, Eyck PT, Rubenstein LM, et al. Association of serum homocysteine, folate, and vitamin B and mood following the Swank and Wahls elimination dietary interventions in relapsing-remitting multiple sclerosis: Secondary analysis of the WAVES trial. Mult Scler Relat Disord. 2023;75:104743. 10.1016/j.msard.2023.104743
