Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
7
Vitamin E (as dl-Alpha tocopheryl acetate)
68 mg
453%
Coenzyme Q10
100 mg
**
The product is found useful for the following medical conditions
Leg Cramps details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.7
10
Fast relief
Most Useful Review
5 people found this helpful
Very easy to swallow. I've taken these CO-Q10 tablets for over 10 years to alleviate the side effects of statins. Recommended by my doctor after starting Lipitor due to severe leg cramps. Within 2-4 hours of taking 200mg of CO-Q10, my leg cramps disappeared, and they've never returned.
Depression details
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.4
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
Q10 alleviates post-stroke depression
We explored the effects of Coenzyme Q10 (Q10) on depression and cognitive deficits following global cerebral ischemia/reperfusion (I/R) injury in rats. In this study, we induced brain injury by blocking blood flow to both carotid arteries for 20 minutes. The rats then received Q10 at a dose of 200 mg/kg for six weeks.
The results illustrated that the I/R injury led to increased anxiety and depressive behaviors in the animals, alongside a noticeable decline in cognitive performance. Moreover, we found that the levels of brain-derived neurotrophic factor (BDNF) and the activity of superoxide dismutase (SOD) were reduced after the stroke.
Upon treating with Q10, we observed significant improvements. The treatment not only decreased brain swelling but also lessened anxiety and depressive-like symptoms. Cognitive impairments improved as well, with increased BDNF levels and SOD activity in the brain tissues of the animals receiving Q10.
Ultimately, this study points to the potential benefits of Q10 supplementation in mitigating symptoms of depression and cognitive issues after a stroke.
The results illustrated that the I/R injury led to increased anxiety and depressive behaviors in the animals, alongside a noticeable decline in cognitive performance. Moreover, we found that the levels of brain-derived neurotrophic factor (BDNF) and the activity of superoxide dismutase (SOD) were reduced after the stroke.
Upon treating with Q10, we observed significant improvements. The treatment not only decreased brain swelling but also lessened anxiety and depressive-like symptoms. Cognitive impairments improved as well, with increased BDNF levels and SOD activity in the brain tissues of the animals receiving Q10.
Ultimately, this study points to the potential benefits of Q10 supplementation in mitigating symptoms of depression and cognitive issues after a stroke.
9
Improved mood
Most Useful Review
9 people found this helpful
Joy to life! I ordered this medication for my grandfather, who had been experiencing depression and lacked the desire to communicate with his family while his appetite diminished. After two weeks of taking one capsule daily in the morning, along with alpha-lipoic acid, his mood significantly improved, and he rediscovered joy in life. He also shared the medication with his wife, who has Alzheimer's disease, and she noticed an improvement too. He expresses nothing but gratitude for these medications! Previously, he had tried various remedies like purification and spirulina, but they were ineffective. I will definitely order more, especially as the price and dosage are very economical. Highly recommend for boosting energy and reducing fatigue!
Bone Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 6 Reviews
8.4
9
Reduced bone pain
Most Useful Review
1 people found this helpful
Works for Gulf War Illness for me! This was recommended along with eliminating glutamate from my diet. By the third day, the constant pain in my body and low-level headache diminished nearly to nothing! I highly recommend it.
Knee Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
USERS' SCORE
Good
Based on 5 Reviews
8.4
9
We explored the impact of Coenzyme Q10 (CoQ10) on knee pain and cartilage health using a rat model of osteoarthritis (OA). Our investigation involved inducing OA in rats through an injection of monosodium iodoacetate into the knee joint. Subsequently, we administered CoQ10 orally starting on the fourth day after the injection.
Pain severity was evaluated by assessing tactile sensitivity, and we also examined the state of cartilage by measuring its thickness and proteoglycan levels. Notably, CoQ10 demonstrated a significant reduction in pain, indicated by increased pain withdrawal thresholds. We observed that the treatment led to a decrease in cartilage degeneration as well.
Moreover, CoQ10 lowered the levels of several inflammatory markers associated with OA, including matrix metalloproteinase-13 and various interleukins. Based on our findings, we conclude that CoQ10 is a promising option for alleviating pain and protecting cartilage in individuals suffering from osteoarthritis.
Pain severity was evaluated by assessing tactile sensitivity, and we also examined the state of cartilage by measuring its thickness and proteoglycan levels. Notably, CoQ10 demonstrated a significant reduction in pain, indicated by increased pain withdrawal thresholds. We observed that the treatment led to a decrease in cartilage degeneration as well.
Moreover, CoQ10 lowered the levels of several inflammatory markers associated with OA, including matrix metalloproteinase-13 and various interleukins. Based on our findings, we conclude that CoQ10 is a promising option for alleviating pain and protecting cartilage in individuals suffering from osteoarthritis.
9
Joint pain relief
Most Useful Review
1 people found this helpful
If you take statins, this is the best choice. These got rid of the joint pain from the statins I take.
Migraine details
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.5
USERS' SCORE
Good
Based on 3 Reviews
8.4
9
We conducted a study to see how coenzyme Q10 (CoQ10) supplementation impacts migraine symptoms and inflammation. This randomized double-blind trial involved 45 non-menopausal women with episodic migraines.
Participants took either 400 mg/day of CoQ10 or a placebo for three months, while continuing their usual migraine medications. We observed a significant reduction in migraine frequency, severity, and duration in the CoQ10 group.
Additionally, CoQ10 levels and inflammatory markers showed some changes, specifically a reduction in certain proteins linked to inflammation. However, not all markers responded positively, indicating some limited effectiveness.
Participants took either 400 mg/day of CoQ10 or a placebo for three months, while continuing their usual migraine medications. We observed a significant reduction in migraine frequency, severity, and duration in the CoQ10 group.
Additionally, CoQ10 levels and inflammatory markers showed some changes, specifically a reduction in certain proteins linked to inflammation. However, not all markers responded positively, indicating some limited effectiveness.
9
Good effects experienced
Most Useful Review
This is by far the best; I have been ordering them for months now, and I am experiencing good effects, particularly for my migraine.
Headache details
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
USERS' SCORE
Good
Based on 2 Reviews
8.3
8
Coenzyme Q10 shows effectiveness against migraines
We investigated the effectiveness of coenzyme Q10 in treating migraines in children, comparing it with the commonly prescribed medication, amitriptyline. Our study involved 72 children, aged 5 to 15, who met the criteria for migraine diagnosis set by the International Headache Society.
Over a three-month period, we observed that coenzyme Q10 had positive therapeutic effects, particularly for those requiring long-term treatment. While amitriptyline provided quicker results, the differences between the two treatments in effectiveness were not significantly noticeable after three months. Both treatments led to improvements in the quality of life for the children involved.
Importantly, we noted that children taking amitriptyline experienced more side effects compared to those receiving coenzyme Q10. This finding positions coenzyme Q10 as a promising option due to its comparable effectiveness and better tolerated adverse effect profile.
Over a three-month period, we observed that coenzyme Q10 had positive therapeutic effects, particularly for those requiring long-term treatment. While amitriptyline provided quicker results, the differences between the two treatments in effectiveness were not significantly noticeable after three months. Both treatments led to improvements in the quality of life for the children involved.
Importantly, we noted that children taking amitriptyline experienced more side effects compared to those receiving coenzyme Q10. This finding positions coenzyme Q10 as a promising option due to its comparable effectiveness and better tolerated adverse effect profile.
7.5
Reduced headache intensity
Most Useful Review
5 people found this helpful
Better absorbency appears to be true according to comparisons. Our family uses Co-Q10 due to chronic migraines. This brand seems to be absorbed better, as noted by relatives who reported their headaches feel less intense after switching from other brands. A relative—a maximum dosage user—sometimes finds his headache completely goes away. However, my husband still experienced no change in the frequency of headaches until we adjusted his dosage timings, which has noticeably reduced the frequency while muting severe pain.
Heart Attack details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
USERS' SCORE
Good
Based on 10 Reviews
8.3
9
We investigated how coenzyme Q10 might help with heart function after a heart attack, particularly focusing on its role in heart remodeling. In a well-structured study involving 55 patients with left ventricular dysfunction following an acute myocardial infarction, we compared the effects of coenzyme Q10 to a placebo over a 24-week period.
Through careful measurements using echocardiography, we observed notable improvements in the walls of the heart and overall heart mass for those taking coenzyme Q10. Specifically, the thickness of the heart walls decreased, and the left ventricular mass was reduced more significantly than in those receiving the placebo.
Additionally, coenzyme Q10 appeared to maintain heart shape and prevent worsening of heart function compared to the placebo group. Our results also highlighted a significant drop in angiotensin-converting enzyme (ACE) levels in the coenzyme Q10 group, suggesting beneficial effects on heart remodeling and function during recovery from a heart attack.
Through careful measurements using echocardiography, we observed notable improvements in the walls of the heart and overall heart mass for those taking coenzyme Q10. Specifically, the thickness of the heart walls decreased, and the left ventricular mass was reduced more significantly than in those receiving the placebo.
Additionally, coenzyme Q10 appeared to maintain heart shape and prevent worsening of heart function compared to the placebo group. Our results also highlighted a significant drop in angiotensin-converting enzyme (ACE) levels in the coenzyme Q10 group, suggesting beneficial effects on heart remodeling and function during recovery from a heart attack.
10
A-Fib support
Most Useful Review
I have A-Fib, and my cardiologist advised me to take CoQ10. This is the best product I've found.
Pelvic Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.3
8
Joint pain relief
Most Useful Review
1 people found this helpful
If you take statins, this is the best option as it alleviated the joint pain caused by the statins I take.
Brain Tumor details
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.6
USERS' SCORE
Good
Based on 3 Reviews
8.2
9
CoQ10 reduces glioblastoma growth
The study focused on understanding how coenzyme Q10 (CoQ) could help manage glioblastoma, a particularly challenging type of brain tumor. We utilized xenograft models with U251 cells implanted in mice to observe tumor growth, inflammation, and vascular changes, alongside assessing the effects of CoQ on various related behaviors, including cell migration and invasion.
We found that CoQ treatment significantly reduced tumor volume in both xenograft and orthotopic models. Interestingly, while it did not directly hinder tumor cell proliferation, it was effective in creating a less hypoxic and vascularized environment. This indicates that CoQ can influence the tumor’s growth dynamics by targeting the underlying conditions that support tumor survival and expansion.
Additionally, CoQ treatment led to a noticeable downregulation of proteins involved in inflammation and angiogenesis, like HIF-1α and NF-kB. This change in molecular activity caused an entire reshaping of the tumor's protein landscape, ultimately impacting how the tumor interacts with its environment. Notably, we observed a restriction in tumor cell migration and invasion, attributed to changes in the cell's structural components.
Overall, our findings suggest that incorporating CoQ into current treatment protocols could provide a holistic approach to combat glioblastoma by simultaneously addressing multiple pathways that facilitate tumor growth and infiltration.
We found that CoQ treatment significantly reduced tumor volume in both xenograft and orthotopic models. Interestingly, while it did not directly hinder tumor cell proliferation, it was effective in creating a less hypoxic and vascularized environment. This indicates that CoQ can influence the tumor’s growth dynamics by targeting the underlying conditions that support tumor survival and expansion.
Additionally, CoQ treatment led to a noticeable downregulation of proteins involved in inflammation and angiogenesis, like HIF-1α and NF-kB. This change in molecular activity caused an entire reshaping of the tumor's protein landscape, ultimately impacting how the tumor interacts with its environment. Notably, we observed a restriction in tumor cell migration and invasion, attributed to changes in the cell's structural components.
Overall, our findings suggest that incorporating CoQ into current treatment protocols could provide a holistic approach to combat glioblastoma by simultaneously addressing multiple pathways that facilitate tumor growth and infiltration.
9
Good for heart and brain
Most Useful Review
1 people found this helpful
The best I've tried so far. The package arrived in good condition, and the ingredients are top quality. This product is truly effective and complete; you can feel the difference from the first dose. I highly recommend it. It aids the heart, brain, and serves as a good antioxidant. The aroma is very light, nothing bothersome.
High Cholesterol details
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.2
USERS' SCORE
Good
Based on 11 Reviews
8.2
9
We delved into the effects of coenzyme Q10 (CoQ10) supplementation on cholesterol levels in adults to determine how it can influence lipid profiles. Through a thorough meta-analysis of fifty randomized controlled trials involving nearly 2800 participants, we explored its potential benefits for reducing cholesterol levels effectively.
Our findings indicated that CoQ10 supplementation significantly lowered levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), while simultaneously increasing high-density lipoprotein cholesterol (HDL-C). This effect was particularly pronounced at a dosage of 400 to 500 mg per day, which was shown to produce the best results in terms of reducing TC.
Overall, the study provided strong evidence that CoQ10 could be a valuable ally in managing high cholesterol, helping to achieve a healthier lipid profile in adults. This research sheds light on a promising dietary supplement that might assist individuals seeking to improve their cholesterol levels effectively.
Our findings indicated that CoQ10 supplementation significantly lowered levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), while simultaneously increasing high-density lipoprotein cholesterol (HDL-C). This effect was particularly pronounced at a dosage of 400 to 500 mg per day, which was shown to produce the best results in terms of reducing TC.
Overall, the study provided strong evidence that CoQ10 could be a valuable ally in managing high cholesterol, helping to achieve a healthier lipid profile in adults. This research sheds light on a promising dietary supplement that might assist individuals seeking to improve their cholesterol levels effectively.
7.5
Youthful appearance
Most Useful Review
2 people found this helpful
This is my favourite product that I have used for years. It's helpful for blood pressure and cholesterol. I take one pill twice daily, and people often comment that I look younger than my age, thanks to this supplement. I’m delighted to have found it on iHerb due to their fast shipping and excellent prices!
Cardiovascular Disease details
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.3
USERS' SCORE
Good
Based on 25 Reviews
8.1
9
We explored the effects of coenzyme Q10 (CoQ-10) on heart failure (HF) patients by analyzing past literature. Our systematic review examined studies from MEDLINE and the Cochrane Library, focusing on how CoQ-10 influences outcomes like HF-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).
The results from 16 studies showed some promising findings. CoQ-10 was found to significantly lower HF-related mortality by 40%, which is a notable benefit for patients. Additionally, we observed improvements in exercise capacity for those taking CoQ-10. However, when it came to the impact on LVEF, the results were not statistically significant. While there wasn’t a clear-cut improvement in LVEF, we acknowledge that this aspect needs further exploration to fully understand CoQ-10's potential.
In summary, CoQ-10 appears to be effective in reducing mortality rates and enhancing exercise capacity among heart failure patients. Nonetheless, the effect on LVEF is still uncertain and merits additional investigation.
The results from 16 studies showed some promising findings. CoQ-10 was found to significantly lower HF-related mortality by 40%, which is a notable benefit for patients. Additionally, we observed improvements in exercise capacity for those taking CoQ-10. However, when it came to the impact on LVEF, the results were not statistically significant. While there wasn’t a clear-cut improvement in LVEF, we acknowledge that this aspect needs further exploration to fully understand CoQ-10's potential.
In summary, CoQ-10 appears to be effective in reducing mortality rates and enhancing exercise capacity among heart failure patients. Nonetheless, the effect on LVEF is still uncertain and merits additional investigation.
9
Heart health boost
Most Useful Review
16 people found this helpful
Excellent for cardiovascular disease. My senior parents have long been fans of this CoQ10 brand recommended by their doctor. It supports their heart health, especially after procedures like angioplasty and open-heart surgery. I've tried it myself when feeling stressed, and it provides a boost in energy and heart health that I can’t get from regular vitamins. Our family highly endorses this product, as it is better absorbed than standard CoQ10 forms.
Heart Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
USERS' SCORE
Good
Based on 41 Reviews
8.1
9
We explored the effectiveness of coenzyme Q10, commonly known as CoQ-10, in treating heart failure (HF) by reviewing multiple studies. Our systematic analysis included research from respected databases like MEDLINE and the Cochrane Library, where we focused on three main outcomes: heart failure-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).
From the 16 studies we examined, we observed that CoQ-10 treatment significantly decreased HF-related mortality by an impressive 40%. Additionally, we noted improvements in exercise capacity among patients, indicating that CoQ-10 could help individuals with heart failure engage in more physical activity and improve their quality of life.
However, when it came to LVEF—the measurement of how well the heart pumps blood—CoQ-10 did not show significant changes. Despite this, we believe that its potential impact on LVEF should be investigated further, as the data does suggest there may be benefits that warrant additional research.
In summary, while CoQ-10 proved to be beneficial in enhancing exercise capacity and reducing mortality associated with heart failure, the exact effects on LVEF remain unclear and would benefit from more focused studies in the future.
From the 16 studies we examined, we observed that CoQ-10 treatment significantly decreased HF-related mortality by an impressive 40%. Additionally, we noted improvements in exercise capacity among patients, indicating that CoQ-10 could help individuals with heart failure engage in more physical activity and improve their quality of life.
However, when it came to LVEF—the measurement of how well the heart pumps blood—CoQ-10 did not show significant changes. Despite this, we believe that its potential impact on LVEF should be investigated further, as the data does suggest there may be benefits that warrant additional research.
In summary, while CoQ-10 proved to be beneficial in enhancing exercise capacity and reducing mortality associated with heart failure, the exact effects on LVEF remain unclear and would benefit from more focused studies in the future.
9
Supports heart health
Most Useful Review
16 people found this helpful
Excellent for heart health. My elderly parents adore this CoQ10 brand, valuable for their heart disease, high cholesterol, and blood pressure management. I too have benefited when feeling fatigued; it provides a boost I can't get from multivitamins. Our family wholeheartedly recommends this product, as it is well-absorbed compared to regular CoQ10 forms.
Sleep Apnea details
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9.5
USERS' SCORE
Good
Based on 2 Reviews
8.1
9.5
Coenzyme Q10 in sleep apnea study
We explored the impact of various treatments, including coenzyme Q10, on obstructive sleep apnea (OSA) in a patient with adult-onset Leigh disease. This condition often presents with severe neurological symptoms, complicating the patients’ overall health and quality of life.
An overnight sleep study revealed the presence of OSA, which had developed shortly before the neurological symptoms became apparent. Treatment included high doses of thiamine, coenzyme Q, L-carnitine, and vitamins C and E, along with effective management of OSA through continuous positive airway pressure (CPAP).
Following this combined approach, we observed a marked clinical improvement not only in the patient's sleep quality but also in their neurological outcomes. While coenzyme Q10 was part of this combination therapy, its specific contribution to alleviating sleep apnea symptoms cannot be isolated from the other treatments. Overall, the findings suggest that recognizing and treating sleep apnea promptly can enhance patients’ well-being and potentially improve neurological conditions associated with Leigh disease.
An overnight sleep study revealed the presence of OSA, which had developed shortly before the neurological symptoms became apparent. Treatment included high doses of thiamine, coenzyme Q, L-carnitine, and vitamins C and E, along with effective management of OSA through continuous positive airway pressure (CPAP).
Following this combined approach, we observed a marked clinical improvement not only in the patient's sleep quality but also in their neurological outcomes. While coenzyme Q10 was part of this combination therapy, its specific contribution to alleviating sleep apnea symptoms cannot be isolated from the other treatments. Overall, the findings suggest that recognizing and treating sleep apnea promptly can enhance patients’ well-being and potentially improve neurological conditions associated with Leigh disease.
6
Increased energy levels
Most Useful Review
I feel much less tired after taking this, even with minimal sleep; I feel energised.
Dizziness details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.7
7
We explored the potential benefits of coenzyme Q10 (CoQ10) in addressing dizziness associated with Meniere-like syndrome. CoQ10 is known to play a crucial role in energy production within cells, particularly those in the heart, and it has been observed to have various health benefits.
In our review of the available research, we noted that CoQ10 may help improve immune function, which can indirectly assist individuals experiencing symptoms like vertigo or dizziness. While there is recognition of CoQ10's positive effects on heart health, the specific impact on dizziness remains somewhat uncertain.
We found that although trials suggested improvements in various cardiovascular conditions, the isolated effectiveness of CoQ10 for treating dizziness specifically wasn't definitively established in the studies reviewed. Thus, we remain cautiously optimistic about its potential while emphasizing the need for further research.
In our review of the available research, we noted that CoQ10 may help improve immune function, which can indirectly assist individuals experiencing symptoms like vertigo or dizziness. While there is recognition of CoQ10's positive effects on heart health, the specific impact on dizziness remains somewhat uncertain.
We found that although trials suggested improvements in various cardiovascular conditions, the isolated effectiveness of CoQ10 for treating dizziness specifically wasn't definitively established in the studies reviewed. Thus, we remain cautiously optimistic about its potential while emphasizing the need for further research.
2
No change felt
Most Useful Review
CoQ10 consists of 100 very good quality long red gel capsules, which I take once a day. However, I still haven't noticed any difference. I continue to feel dizzy but am contemplating increasing my intake to two tablets daily. It’s thought to help boost energy utilization for the heart, brain, and heart muscle. There is no taste.
