Last update
5/2/2026
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7.2
USERS' SCORE
Good
Based on 2 Reviews
8.3
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
7
Vitamin E (as dl-Alpha tocopheryl acetate)
68 mg
453%
Coenzyme Q10
100 mg
**
Top Medical Research Studies
8
We systematically reviewed randomized controlled trials comparing coenzyme Q10 with placebo for migraine prevention in adults. Our meta-analysis examined study data from major medical databases through December 2019, assessing how CoQ10 affects migraine severity, attack frequency, and headache duration.
The evidence suggests CoQ10 has beneficial effects in reducing both how often migraines occur and how long they last. These findings indicate CoQ10 may be a useful preventive option for migraine sufferers, though further research could help clarify optimal dosing and its effects when combined with other supplements.
The evidence suggests CoQ10 has beneficial effects in reducing both how often migraines occur and how long they last. These findings indicate CoQ10 may be a useful preventive option for migraine sufferers, though further research could help clarify optimal dosing and its effects when combined with other supplements.
Read More
4
Moderate evidence for coenzyme Q10 migraine prevention
Researchers examined the evidence for various nutraceutical approaches to migraine prevention, including coenzyme Q10. The analysis revealed that coenzyme Q10 carries Level C evidence—meaning modest research support—for helping prevent migraines, with the advantage of causing few adverse effects.
This moderate level of evidence suggests coenzyme Q10 may offer some benefit, though stronger research is still needed to confirm its effectiveness compared to other prevention strategies. The low rate of side effects makes it a relatively safe option worth considering for migraine sufferers.
This moderate level of evidence suggests coenzyme Q10 may offer some benefit, though stronger research is still needed to confirm its effectiveness compared to other prevention strategies. The low rate of side effects makes it a relatively safe option worth considering for migraine sufferers.
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0
CoQ10 ineffective; melatonin resolved pediatric stabbing headache
A 7-year-old boy experienced primary stabbing headache—brief, sharp jabs lasting just a few seconds that struck without warning. After a trial of Coenzyme Q10 produced no improvement, we switched to melatonin treatment, which resulted in complete symptom relief without any adverse effects during follow-up.
This case highlights melatonin as a potentially innovative and safe therapeutic option for this rare pediatric headache condition, offering hope where traditional medications like indomethacin often fall short or cause unwanted side effects.
This case highlights melatonin as a potentially innovative and safe therapeutic option for this rare pediatric headache condition, offering hope where traditional medications like indomethacin often fall short or cause unwanted side effects.
Read More
Most Useful Reviews
7.5
Reduced headache intensity
5 people found this helpful
Better absorbency appears to be true according to comparisons. Our family uses Co-Q10 due to chronic migraines. This brand seems to be absorbed better, as noted by relatives who reported their headaches feel less intense after switching from other brands. A relative—a maximum dosage user—sometimes finds his headache completely goes away. However, my husband still experienced no change in the frequency of headaches until we adjusted his dosage timings, which has noticeably reduced the frequency while muting severe pain.
Read More
6
Slight headache relief
I took two pills of 200mg in the morning and another 100mg pill of Coenzyme Q10 in the afternoon. I feel like my headaches are slightly improving, possibly due to my blood pressure.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7.2
- All Researches
9
Double-blind trial shows migraine improvement
We tested whether combining Coenzyme Q10 (30 mg/day) and L-carnitine (500 mg/day) could help migraine sufferers in a rigorous double-blind, placebo-controlled study involving 56 adults aged 20–40. Over 8 weeks, the supplement combination significantly reduced migraine severity, duration, and frequency compared to placebo. The treatment also lowered serum lactate levels, a marker of mitochondrial energy problems linked to migraines. These results suggest that addressing mitochondrial dysfunction through this supplement combination may offer real benefits for migraine management.
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9
We delved into the role of Coenzyme Q10 (CoQ10) in managing headache symptoms, particularly migraines. This exploration stemmed from the understanding that migraines are complex and may be influenced by various factors, including energy deficits in the brain.
CoQ10 is recognized for its function in boosting mitochondrial energy metabolism, which is seen as a potential avenue for alleviating headaches. We learned that certain nutrients, including CoQ10, have shown promise in reducing the frequency and severity of migraine attacks. In fact, studies reported significant reductions in headache occurrences when individuals incorporated CoQ10 into their regimen.
While we found evidence supporting CoQ10's effectiveness, it's important to note that it’s often studied alongside other supplements. This means that while CoQ10 may play a beneficial role, it's challenging to pinpoint its isolated effects definitively. Nevertheless, the insights from the research suggest that adding CoQ10 to our preventive strategies for migraines could be a worthy consideration.
CoQ10 is recognized for its function in boosting mitochondrial energy metabolism, which is seen as a potential avenue for alleviating headaches. We learned that certain nutrients, including CoQ10, have shown promise in reducing the frequency and severity of migraine attacks. In fact, studies reported significant reductions in headache occurrences when individuals incorporated CoQ10 into their regimen.
While we found evidence supporting CoQ10's effectiveness, it's important to note that it’s often studied alongside other supplements. This means that while CoQ10 may play a beneficial role, it's challenging to pinpoint its isolated effects definitively. Nevertheless, the insights from the research suggest that adding CoQ10 to our preventive strategies for migraines could be a worthy consideration.
Read More
8
Combination supplement shows preliminary migraine symptom relief
We evaluated how a combination supplement—containing CoQ10, riboflavin, magnesium, and feverfew—affected vestibular migraine symptoms in 82 patients over three months. Participants received lifestyle advice on sleep, hydration, exercise, and nutrition alongside the supplement.
The results were encouraging: symptom severity and frequency both improved by roughly 44%, with about half of patients reporting meaningful improvement. No serious side effects were noted. While these findings suggest nonprescription therapies may help reduce vertigo and dizziness associated with vestibular migraine, the study design has limitations that prevent us from definitively attributing benefits to CoQ10 alone—the supplement contained multiple active ingredients, and there was no control group for comparison.
The results were encouraging: symptom severity and frequency both improved by roughly 44%, with about half of patients reporting meaningful improvement. No serious side effects were noted. While these findings suggest nonprescription therapies may help reduce vertigo and dizziness associated with vestibular migraine, the study design has limitations that prevent us from definitively attributing benefits to CoQ10 alone—the supplement contained multiple active ingredients, and there was no control group for comparison.
Read More
8
We systematically reviewed randomized controlled trials comparing coenzyme Q10 with placebo for migraine prevention in adults. Our meta-analysis examined study data from major medical databases through December 2019, assessing how CoQ10 affects migraine severity, attack frequency, and headache duration.
The evidence suggests CoQ10 has beneficial effects in reducing both how often migraines occur and how long they last. These findings indicate CoQ10 may be a useful preventive option for migraine sufferers, though further research could help clarify optimal dosing and its effects when combined with other supplements.
The evidence suggests CoQ10 has beneficial effects in reducing both how often migraines occur and how long they last. These findings indicate CoQ10 may be a useful preventive option for migraine sufferers, though further research could help clarify optimal dosing and its effects when combined with other supplements.
Read More
8
Multi-compound supplement trial shows promise in pediatric headaches
We examined 92 children and teens (ages 6-17) with primary headaches who received one of three supplement compounds over 12 months. Compound 3, which included magnesium oxide, feverfew, andrographis, coenzyme Q10, and vitamin B2, proved particularly effective.
All three supplement regimens significantly reduced headache frequency and decreased the need for pain medications (p=0.000001). Compound 3 showed mixed results depending on headache type—it outperformed the others for migraines with aura, but was less effective for other headache types compared to compound 2.
Overall, parents and children found the supplements well-tolerated and effective for headache prevention, making them a promising complementary approach to traditional medications.
All three supplement regimens significantly reduced headache frequency and decreased the need for pain medications (p=0.000001). Compound 3 showed mixed results depending on headache type—it outperformed the others for migraines with aura, but was less effective for other headache types compared to compound 2.
Overall, parents and children found the supplements well-tolerated and effective for headache prevention, making them a promising complementary approach to traditional medications.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Reduced headache intensity
5 people found this helpful
Better absorbency appears to be true according to comparisons. Our family uses Co-Q10 due to chronic migraines. This brand seems to be absorbed better, as noted by relatives who reported their headaches feel less intense after switching from other brands. A relative—a maximum dosage user—sometimes finds his headache completely goes away. However, my husband still experienced no change in the frequency of headaches until we adjusted his dosage timings, which has noticeably reduced the frequency while muting severe pain.
Read More
6
Slight headache relief
I took two pills of 200mg in the morning and another 100mg pill of Coenzyme Q10 in the afternoon. I feel like my headaches are slightly improving, possibly due to my blood pressure.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Takle M, Strelzik J, Langdon R, Turner A, McClintock W, et al. Coenzyme Q10 Supplementation May Be Correlated With Resolution of New Daily Persistent Headache. J Child Neurol. 2025. 10.1177/08830738251366866
- Tepper SJ, Tepper K. Nutraceuticals and Headache 2024: Riboflavin, Coenzyme Q10, Feverfew, Magnesium, Melatonin, and Butterbur. Curr Pain Headache Rep. 2025;29:33. 10.1007/s11916-025-01358-3
- Hannigan IP, Rosengren SM, Di Tanna GL, Watson SRD, Welgampola MS. Effects of nonprescription therapies on vestibular migraine: a questionnaire-based observational study. Intern Med J. 2024;54:916. 10.1111/imj.16314
- Dahri M, Sarafan Sadeghi A, Pahlavani N, Nattagh-Eshtivani E, Hashemilar M, et al. The Effects of Coenzyme Q10 Supplementation on Oxidative Status and Lipid Profile in Migraine Patients: A Randomized Double-Blinded Controlled Clinical Trial. Clin Nutr Res. 2023;12:257. 10.7762/cnr.2023.12.4.257
- Yaghini O, Hoseini N, Ghazavi MR, Mansouri V, Nasiri J, et al. A Comparative Study on the Efficacy of Coenzyme Q10 and Amitriptyline in the Prophylactic Treatment of Migraine Headaches in Children: A Randomized Controlled Trial. Adv Biomed Res. 2022;11:43. 10.4103/abr.abr_235_20
- Kaur K, Hernandez V, Al Hajaj SW, Ebrahim AM, Razack M, et al. The Efficacy of Herbal Supplements and Nutraceuticals for Prevention of Migraine: Can They Help?. Cureus. 2021;13:e14868. 10.7759/cureus.14868
- Sazali S, Badrin S, Norhayati MN, Idris NS. Coenzyme Q10 supplementation for prophylaxis in adult patients with migraine-a meta-analysis. BMJ Open. 2021;11:e039358. 10.1136/bmjopen-2020-039358
- Vikelis M, Dermitzakis EV, Vlachos GS, Soldatos P, Spingos KC, et al. Open Label Prospective Experience of Supplementation with a Fixed Combination of Magnesium, Vitamin B2, Feverfew, Andrographis Paniculata and Coenzyme Q10 for Episodic Migraine Prophylaxis. J Clin Med. 2020;10. 10.3390/jcm10010067
- Onofri A, Necozione S, Tozzi E. Complementary and alternative medicine (CAM) in headache of children and adolescents: open-label Italian study. Clin Ter. 2020;171:e393. 10.7417/CT.2020.2246
- Parohan M, Sarraf P, Javanbakht MH, Foroushani AR, Ranji-Burachaloo S, et al. The synergistic effects of nano-curcumin and coenzyme Q10 supplementation in migraine prophylaxis: a randomized, placebo-controlled, double-blind trial. Nutr Neurosci. 2021;24:317. 10.1080/1028415X.2019.1627770
- Moscano F, Guiducci M, Maltoni L, Striano P, Ledda MG, et al. An observational study of fixed-dose Tanacetum parthenium nutraceutical preparation for prophylaxis of pediatric headache. Ital J Pediatr. 2019;45:36. 10.1186/s13052-019-0624-z
- Hajihashemi P, Askari G, Khorvash F, Reza Maracy M, Nourian M. The effects of concurrent Coenzyme Q10, L-carnitine supplementation in migraine prophylaxis: A randomized, placebo-controlled, double-blind trial. Cephalalgia. 2019;39:648. 10.1177/0333102418821661
- Zeng Z, Li Y, Lu S, Huang W, Di W. Efficacy of CoQ10 as supplementation for migraine: A meta-analysis. Acta Neurol Scand. 2019;139:284. 10.1111/ane.13051
- Bermúdez Salazar M, Rojas Cerón CA, Arana Muñoz RS. Prophylaxis with melatonin for primary stabbing headache in pediatrics: a case report. Colomb Med (Cali). 2018;49:244. 10.25100/cm.v49i2.3857
- Dahri M, Tarighat-Esfanjani A, Asghari-Jafarabadi M, Hashemilar M. Oral coenzyme Q10 supplementation in patients with migraine: Effects on clinical features and inflammatory markers. Nutr Neurosci. 2019;22:607. 10.1080/1028415X.2017.1421039
- Guilbot A, Bangratz M, Ait Abdellah S, Lucas C. A combination of coenzyme Q10, feverfew and magnesium for migraine prophylaxis: a prospective observational study. BMC Complement Altern Med. 2017;17:433. 10.1186/s12906-017-1933-7
- Tavasoli A, Rezazadeh M, Kachuei M. Eyebrow bleeding as a rare migraine symptom: a case report. Ann Med Surg (Lond). 2024;86:7377. 10.1097/MS9.0000000000002655
- Hajhashemy Z, Golpour-Hamedani S, Eshaghian N, Sadeghi O, Khorvash F, et al. Practical supplements for prevention and management of migraine attacks: a narrative review. Front Nutr. 2024;11:1433390. 10.3389/fnut.2024.1433390
- Gaul C, Zaranek L, Goßrau G. [Complementary and supplementary procedures in the treatment of headache]. Schmerz. 2023;37:448. 10.1007/s00482-023-00738-1
- Quintana S, Russo M, Torelli P. Nutraceuticals and migraine: further strategy for the treatment of specific conditions. Neurol Sci. 2022;43:6565. 10.1007/s10072-022-06250-1
- Ariyanfar S, Razeghi Jahromi S, Togha M, Ghorbani Z. Review on Headache Related to Dietary Supplements. Curr Pain Headache Rep. 2022;26:193. 10.1007/s11916-022-01019-9
- Lisicki M, Schoenen J. Metabolic treatments of migraine. Expert Rev Neurother. 2020;20:295. 10.1080/14737175.2020.1729130
