NOW Supplements, Zinc (Zinc Gluconate) 50 mg

Zinc shortens cold duration variability

Quantile Treatment Effect of Zinc Lozenges on Common Cold Duration: A Novel Approach to Analyze the Effect of Treatment on Illness Duration.

Most Relevant Research

We explored how zinc lozenges affect the duration of the common cold through a detailed analysis of multiple trials. In particular, we focused on the Mossad (1996) trial involving zinc gluconate lozenges, which revealed an average reduction of cold duration by about 4.0 days. While that sounds promising, our findings through a quantile treatment effect (QTE) analysis tell a more nuanced story.

Interestingly, the QTE analysis showed that for individuals suffering from lengthy colds lasting 15 to 17 days, the zinc lozenges could shorten their illness by as much as 8 days. On the flip side, those with shorter, 2-day colds only experienced a 1-day reduction in sickness. This suggests that while zinc may help, its effectiveness varies significantly depending on the initial duration of the cold, making the overall average effect less informative than we might think.

Our examination extended to three trials that used zinc acetate lozenges, yielding a similar average reduction of around 2.7 days. However, again, those averages concealed varying effects for short and long colds, highlighting the importance of looking beyond simple averages in treatment studies.

Overall, we observed that zinc lozenges can indeed help with cold duration, but the extent of that help is very much dependent on how long a person has been suffering. This approach to understanding treatment effects through QTE analysis could have important implications not just for cold treatment but also for analyzing other health outcomes.

9.5

Instant relief

Most Useful Review

This form of zinc works instantly at the first signs of a common cold. I combine one tablet of zinc with 1000mg of vitamin C, and I feel healthy by morning. It’s essential during winter, and I struggled to find this form as it was quickly sold out. I'm grateful for the chance to stay healthy!

Osteoporosis

Zinc intake may protect bones

Based on 10 Researches

The association between dietary zinc intake and osteopenia, osteoporosis in patients with rheumatoid arthritis.

Most Relevant Research

We investigated the connection between dietary zinc intake and the prevalence of osteoporosis and osteopenia in patients with rheumatoid arthritis (RA). Using data from the National Health and Nutrition Examination Survey collected over several years, we applied various statistical methods to analyze how zinc impacts bone health in these patients.

Our findings revealed that higher dietary zinc intake appears to be linked with a lower incidence of osteopenia and osteoporosis among individuals with RA. This suggests that consuming adequate amounts of zinc might support better bone health for those suffering from this chronic condition.

Despite our positive findings, we acknowledge that further research, including longitudinal and randomized trials, is essential for confirming these results and understanding the underlying mechanisms at play. However, the evidence from our analysis encourages a focus on dietary zinc as a possible factor in maintaining bone health for patients with RA.

9.5

Supports osteoporosis treatment

Most Useful Review

A tiny capsule of zinc helps combat various health issues. This small dietary supplement is easy to consume and plays a crucial role in preventing diseases such as osteoporosis. Zinc contributes to skin cell renewal and collagen formation, reducing dryness and helping combat wrinkles and acne. The importance of zinc in overall health cannot be overstated, particularly in maintaining beauty and preventing various health problems.

Influenza

Zinc may prevent influenza entry

Epipharyngeal Abrasive Therapy Down-regulates the Expression of Cav1.2: A Key Molecule in Influenza Virus Entry.

Most Relevant Research

We investigated how zinc, delivered through epipharyngeal abrasive therapy (EAT), might impact the expression of a key molecule known as Cav1.2, which plays a crucial role in allowing the influenza A virus to enter cells. The study included two groups of patients: one group that received EAT, which involved scratching the epipharyngeal mucosa with a zinc chloride-treated swab, and another group that did not receive this treatment.

By analyzing tissue samples, we observed that the levels of Cav1.2 were significantly lower in the EAT-treated patients compared to those who were not treated. In fact, the expression of Cav1.2 in the patients who underwent EAT was measured to be 4.19 times lower than in the non-treated group. This suggests that the squamous metaplasia induced by EAT might help reduce the entry of the influenza virus by down-regulating this key protein.

Our findings indicate that EAT, through its zinc content, could serve as a simple and effective method to potentially prevent influenza infection by limiting the virus's ability to enter cells.

9.5

Strengthens hair

Most Useful Review

Zinc is vital for strengthening my hair as it boosts immunity, aids wound healing, and alleviates influenza symptoms.

Anxiety

Zinc may alleviate anxiety symptoms

Based on 8 Researches

A systematic review of the association between zinc and anxiety.

Most Relevant Research

We explored the connection between zinc intake and anxiety in adults through a systematic review of nine original studies. Two of these studies looked at how zinc consumption impacts anxiety, while the other seven focused on the relationship between serum zinc levels and anxiety symptoms. Our analysis included studies published in English within peer-reviewed journals, ensuring a solid foundation for understanding this potential link.

What we discovered was quite illuminating. The data indicated that individuals experiencing anxiety often had lower levels of zinc in their serum compared to those who did not suffer from anxiety. Additionally, we observed an inverse association between zinc intake and anxiety levels. This suggests that higher consumption of zinc may contribute to reduced anxiety symptoms.

In conclusion, the evidence points towards zinc playing a positive role in treating anxiety, although we acknowledge some limitations in the available studies. This means zinc supplementation could be a beneficial strategy for those looking to manage their anxiety, but more research is needed to confirm these findings and understand the underlying mechanisms better.

Improved anxiety treatment

Most Useful Review

Amazing! I bought this for my wife who suffered from hormonal breakouts. After switching to Now Foods Picolinate Zinc, she noticed a significant improvement in her skin and a reduction in her anxiety. She found the capsules easy to swallow, which was a big relief. It also seemed to help control her appetite and boost her mood. I will definitely purchase this again!

Athlete’s Foot

Zinc aids athlete's foot treatment

Efficacy of undecylenic acid-zinc undecylenate powder in culture positive tinea pedis.

Most Relevant Research

We explored the effectiveness of a powder containing 2% undecylenic acid and 20% zinc undecylenate for treating athlete's foot, also known as tinea pedis. In a double-blind study, 151 participants were assigned to apply either the active powder or a placebo twice daily for four weeks. The results were telling.

From the 85 patients with confirmed fungal infections, a remarkable 88% of those using the active powder had negative cultures after the treatment, compared to only 17% in the placebo group. Additionally, 80% of those on the active treatment were found to be free of fungus in KOH skin scrapings after four weeks, while only 49% of placebo users achieved this. Furthermore, we observed significant improvement in symptoms like itching, burning, erythema, and scaling, with no side effects reported.

Overall, our findings indicate that the combination of undecylenic acid and zinc may offer a robust solution for individuals suffering from athlete's foot, effectively reducing fungal presence and alleviating uncomfortable symptoms. However, it is important to note that while zinc played a role in this combination treatment, we cannot fully assess its isolated effect on its own without further studies.

9.5

Odour elimination

Most Useful Review

ZINC IN CAPSULES! HOORAY! It’s crucial to take supplements, especially minerals, in capsule form. Tablets often contain too many binders. Zinc has greatly improved hygiene for my family by eliminating foot and scalp odours. Just one capsule a day does the job!

Bloating

This zinc is remarkable. It’s easy to digest and does not cause any bloating or eructation. I truly appreciated it.

Cancer

Zinc's role in cancer immunity

cancer cells outcompete macrophages for microenvironmental zinc to drive immunotherapy resistance.

Most Relevant Research

We explored how zinc levels impact cancer cells and immune function, particularly focusing on macrophages, which are crucial for our body’s defense against tumors. Our research revealed that cancer cells often have decreased expression of specific genes tied to immune response, and this links to resistance against therapies designed to unblock immune checkpoints.

By upregulating a zinc importer known as SLC39A9, these cancer cells manage to hoard zinc for themselves, leaving the surrounding tumor microenvironment (TME) depleted of this vital nutrient. This competition for zinc results in macrophages becoming zinc-starved, which diminishes their ability to perform essential tasks like engulfing and destroying cancer cells.

Interestingly, we found that when we replenished zinc levels in the TME—through a dietary intervention—these macrophages could regain their pro-phagocytic function. This change significantly improved the response of certain tumors to immunotherapy treatments. Notably, T cells weren’t required for this transformation, indicating that macrophages alone play a pivotal role.

Our results are clinically relevant, showing that cancer patients with reduced zinc levels in their body tend to experience worse outcomes. Overall, we identified a new mechanism by which cancer cells can disrupt immune function, highlighting zinc’s critical role in both tumor environments and immunotherapy effectiveness.

9.5

Reduces cancer risk

Most Useful Review

Zinc effectively stimulates the immune system and shortens the duration of colds. It aids vision and reduces the risk of age-related macular degeneration. As an antioxidant, zinc plays a vital role in reducing oxidative stress and therefore lowers cancer risk.

Chronic Cough

I often fall ill, so I decided to try zinc as an immune booster after reading about its benefits. I took it alongside Ester C for 1.5 months. Recently, I was exposed to flu, yet despite the infection in the house, I did not get sick! My son experienced a mild form of the illness, but he began taking zinc and recovered quickly. In contrast, my father-in-law, who refuses to take supplements, suffered significantly from the flu. It seems zinc truly works wonders for immunity!

Cold Sores

Zinc cream alleviates cold sores

Based on 9 Researches

A randomized clinical trial on the treatment of oral herpes with topical zinc oxide/glycine.

Most Relevant Research

We conducted a double-blind, placebo-controlled clinical trial to explore the effectiveness of a zinc oxide/glycine cream in treating cold sores caused by facial and circumoral herpes. By dividing 46 participants into two groups, one receiving the zinc treatment and the other a placebo, we aimed to measure how this formulation affected the duration and severity of cold sore symptoms.

Our results were quite promising! Participants who began using the zinc oxide/glycine cream within the first 24 hours of noticing symptoms experienced cold sore lesions that lasted only an average of 5 days, compared to 6.5 days for those on the placebo. Additionally, we noticed a significant reduction in the overall severity of their symptoms, including blistering, soreness, itching, and tingling.

As for side effects, subjects treated with the zinc cream experienced only minor and reversible issues typical of ionic zinc salt solutions. This indicates that the zinc oxide/glycine cream is not only effective but also safe for treating cold sores, presenting a valuable option for many people seeking relief from this common condition.

9.5

Prevented infections

Most Useful Review

I often fall ill, but since taking Zinc, I have noticed a significant improvement. A recent visit from my mother-in-law brought the flu, yet I remained unaffected! My son also followed my advice and took Zinc along with Kagocel, recovering quickly. I am truly amazed by the effectiveness of Zinc.

Constipation

Zinc may mitigate granisetron constipation

Carbon monoxide contributes to the constipating effects of granisetron in rat colon.

Most Relevant Research

We investigated how zinc might play a role in alleviating the constipation effects caused by granisetron, a medication often used to prevent nausea. In the studies, male rats were treated with varying doses of granisetron, alongside zinc protoporphyrin IX (ZnPPIX), to see how these compounds interacted.

Interestingly, while granisetron was found to increase the time to first defecation in the rats, ZnPPIX alone did not have a notable effect on constipation. However, when combined with granisetron, ZnPPIX successfully reversed the constipation induced by this medication. This suggests that zinc, acting through the heme oxygenase/carbon monoxide (HO/CO) pathway, could potentially mitigate constipation.

Nonetheless, it’s crucial to note that ZnPPIX’s effectiveness was only observed when paired with granisetron; its standalone administration didn’t significantly alter gastrointestinal motility. This highlights a specific interaction rather than a general benefit of zinc in treating constipation.

9.5

Improved digestion

Most Useful Review

The quality of this supplement is excellent. The balanced ingredients have improved my health as they contain natural substances. The capsules are conveniently sized and easy to swallow, with a neutral taste. It has notably helped my digestion and alleviated constipation. I highly recommend purchasing it!

Gastritis

Zinc protects against gastritis damage

Based on 8 Researches

Zinc supplementation alleviates oxidative stress to inhibit chronic gastritis the ROS/NF-κB pathway in a mouse model.

Most Relevant Research

We investigated how zinc supplementation impacts chronic gastritis, particularly in the context of oxidative stress and inflammation. By establishing models of inflammatory injury in C57BL/6 mice, we were able to analyze the effects of zinc on the gastric mucosa, which is crucial for maintaining digestive health.

Our findings revealed that when the mice were exposed to a compound known to induce inflammation, there was a noticeable rise in reactive oxygen species (ROS), signaling an increase in oxidative stress. This stress resulted in an uptick in certain harmful factors related to inflammation and cell death. However, when we introduced zinc as a supplement, it effectively reduced these damaging factors, alleviating inflammation and the resulting cell death in both the mouse stomach and cultured cells.

Overall, our study indicates that zinc supplementation can play a significant role in controlling inflammation and protecting against cellular damage caused by oxidative stress in chronic gastritis. By modulating the ROS/NF-κB signaling pathway, zinc demonstrates potential as a protective agent for gastric health.

9.5

Affordable gastritis option

Most Useful Review

Zinc is essential for restoring the gastrointestinal tract and serves as a co-enzyme. I purchased a convenient course, taking one capsule after dinner. With 120 capsules, it lasts us about a month and a half at an affordable price. Picolinate is the best form for gastritis and ulcers. Pay attention to dosages; this one offers 50mg.

Migraine

Zinc reduces migraine symptoms

Assessing the Effect of Zinc Supplementation on the Frequency of Migraine Attack, Duration, Severity, Lipid Profile and hs-CRP in Adult Women.

Most Relevant Research

This study was designed as a randomized double-blind, placebo-controlled trial to examine how zinc gluconate supplementation might alleviate migraine symptoms in adult women. We followed 60 women, averaging about 35 years old, who either received 15 mg of zinc per day or a placebo for a duration of 12 weeks.

Over the trial, we observed significant improvements in those taking zinc. The frequency of migraine attacks, as well as the duration and severity of the headaches, drastically decreased for participants receiving zinc. We used various assessments, such as a numerical rating scale and the Migraine Disability Assessment test, to evaluate these changes.

Additionally, zinc supplementation showed a notable reduction in levels of low-density lipoprotein (LDL) cholesterol and high-sensitivity C-reactive protein (hs-CRP), both of which are associated with inflammation. However, no significant changes in triglycerides or high-density lipoprotein (HDL) levels were seen. After taking initial values into account, the changes in lipid levels and hs-CRP weren’t significant.

Overall, we found that zinc supplementation can beneficially impact migraine symptoms, reducing their severity and frequency among women. This offers a promising direction for migraine management without the side effects often associated with traditional medications.

9.5

Improved migraine frequency

Most Useful Review

Great! It normalises sleep when I take 2 capsules regularly. It has greatly improved my migraines, which now pass in a couple of hours instead of taking half a day. I have also found that PMS and menstruation are easier to endure with regular magnesium intake. Chronic nasal pain has not worsened either. I suspect the magnesium, along with my other supplements, has been beneficial, but I was pleasantly surprised by the result. No allergies or stomach issues, and the quality is excellent.

Arthritis

Zinc alleviates arthritis symptoms

Therapeutic Dose of Zinc Aspartate and Zinc Citrate Attenuates Disease Activity Indices in Rheumatoid Arthritis.

Most Relevant Research

We explored the effects of zinc supplements—specifically zinc aspartate and zinc citrate—on reducing the symptoms of rheumatoid arthritis. In our study, we induced arthritis in male Wistar rats using a collagen-related method and then treated the rats with these zinc compounds over a four-week period. Our objective was to evaluate how these compounds could impact the disease's severity and markers associated with rheumatoid arthritis.

The results were quite promising. Both zinc aspartate and zinc citrate, administered at a therapeutic dose of 50 mg of elemental zinc per day, showed a significant reduction in the clinical symptoms associated with arthritis. Furthermore, these compounds displayed antibacterial properties against Escherichia coli, which is notable since rheumatoid arthritis patients often suffer from increased sensitivity to bacterial infections.

Importantly, we found no adverse effects on liver or kidney function in the rats that received the zinc treatment. This highlights the potential of zinc compounds not only as anti-inflammatory agents but also as preventive measures against microbial growth that can complicate rheumatoid arthritis.

9.5

Improved sleep

Most Useful Review

I purchased these vitamins to strengthen my immune system and support my joints, as I suffer from arthritis. I have recently started taking them and have noticed no negative effects. My sleep has improved, and there’s new hair growth in bald patches. Overall, I’m pleased with the vitamins and would recommend them for arthritis.

Chest Pain

Zinc treatment for angina pectoris

High-dose zinc to terminate angina pectoris: a review and hypothesis for action by ICAM inhibition.

Most Relevant Research

We delved into an intriguing question: Can high doses of zinc help relieve chest pain caused by angina pectoris? Our research reviewed studies that highlight how zinc may play a role in managing this condition. Angina pectoris often results from arteriosclerosis, where the arteries become narrowed due to cholesterol buildup and other factors.

We discovered that patients with severe atherosclerosis showed promising improvements when treated with high-dose zinc. Specifically, a treatment regimen involved raising serum zinc levels significantly, resulting in symptom relief for many individuals. In one notable case, 12 out of 16 patients experienced measurable benefits, including one patient who also suffered from Raynaud's disease.

Furthermore, our analysis noted that long-term exposure to zinc in the environment correlated with reduced incidence of angina and ischemic events during exercise. Zinc appears to possess antioxidant properties, which may protect against the oxidation of LDL cholesterol, a key player in artery damage. By blocking certain inflammatory factors and promoting better circulation, zinc might enhance heart function and alleviate chest pain.

Based on these findings, we propose that zinc treatment should be considered a fundamental option in both prevention and therapy for atherosclerosis-related chest pain. This could lead to a renewed focus on restoring a healthier cardiac function among those affected by these conditions.

9.5

Life-saving zinc

Most Useful Review

Very excellent; I felt inspired to purchase this a month before I had corona when I was already suffering from chest allergies and was immunocompromised. The doctor assured me that the zinc I took is what saved my life.

Frozen Shoulder

I followed the instructions closely, and initially experienced a surge of energy and mental clarity. My skin, which had been dry with a rash on my shoulders for years, has begun to recover. I am incredibly happy with the results.

Heart Disease

Zinc benefits heart health post-cisplatin

Based on 4 Researches

Role of zinc oxide nanoparticles supplementation on alleviate side effects of cisplatin induced cardiotoxicity in rats.

Most Relevant Research

We explored the potential benefits of zinc oxide nanoparticles (ZnONPs) in preventing heart damage caused by cisplatin, a powerful chemotherapy drug known for its efficacy but also for its side effects, particularly cardiotoxicity.

In our study, rats were divided into several groups, including control groups and those receiving different doses of ZnONPs. We specifically looked at a range of health markers such as lipid levels, antioxidant activity, and inflammation in heart tissues to see how ZnONPs could help soften the impact of cisplatin on heart health.

As we gradually increased the dosage of ZnONPs to 50 mg/kg, we observed significant improvements across the various health parameters examined. Notably, at this optimal dose, the rats' heart health markers showed a remarkable recovery, aligning closely with those in the healthy control group. This suggests that ZnONPs effectively protect heart tissue from oxidative stress and inflammation associated with cisplatin treatment.

Overall, our findings highlight the promising role of zinc oxide nanoparticles in mitigating heart damage linked to cancer treatments, paving the way for further research in this arena.

8.8

Conquer heart disease

Most Useful Review

Excellent form of zinc. I purchased this supplement for its bioavailable zinc picolinate form and high dosage of 50 mg, which is ideal for therapeutic use. It proved effective. Alongside other supplements, I've found that we can overcome heart disease without medication.

High Cholesterol

Zinc improves cholesterol levels

Effect of Zinc Supplementation on Lipid Profile and Body Composition in Patients with Type 2 Diabetes Mellitus: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis.

Most Relevant Research

We explored how zinc supplementation affects cholesterol levels and body composition in patients with type 2 diabetes. By reviewing data from nineteen randomized controlled trials, involving 1,357 participants, we uncovered significant findings regarding lipid profiles.

Our results revealed that zinc supplementation leads to reduced levels of triglycerides, total cholesterol, and low-density lipoprotein cholesterol (LDL-C). Specifically, we noted reductions of 17.41 mg/dL in triglycerides, 19.60 mg/dL in total cholesterol, and 8.80 mg/dL in LDL-C. Furthermore, we observed an increase in high-density lipoprotein cholesterol (HDL-C) by 4.82 mg/dL, which is often termed "good" cholesterol.

While zinc appears to positively influence cholesterol levels, it's interesting to note that it did not have a significant impact on body weight. The body mass index (BMI) did show a slight decrease of 0.53 kg/m², but overall body weight remained unchanged.

In conclusion, our findings suggest that zinc supplementation could be a beneficial strategy for improving cholesterol levels in individuals with type 2 diabetes, thus contributing positively to their overall health and well-being.

9.5

Heart health improves

Most Useful Review

Excellent quality supplement, great dosage ratio. My high cholesterol hasn't increased while taking it, and my heart feels fantastic.

Insomnia

Zinc promotes sleep in mice

Based on 3 Researches

Zinc-containing yeast extract promotes nonrapid eye movement sleep in mice.

Most Relevant Research

We explored the effects of zinc on sleep by looking at how it might help with insomnia. In our study, we gave mice a zinc-containing yeast extract and monitored their behavior and brain activity. The results were quite promising.

We found that administering zinc at doses of 40 and 80 mg/kg led to a significant increase in non-rapid eye movement (NREM) sleep. This means that the mice were not only sleeping longer but also showed less activity, which is a good indicator of effective sleep. Interestingly, we did not observe any changes in rapid eye movement (REM) sleep, a crucial sleep phase for dreaming and deep rest.

Importantly, we didn’t see any negative side effects, such as rebound insomnia, within 24 hours after treating the mice. This suggests that zinc could be a safe option for those struggling with sleep issues, unlike other mineral extracts we tested, such as manganese, iron, and copper, which did not affect locomotor activity at all.

Overall, our findings provide the first evidence that zinc has a direct role in promoting sleep, opening up exciting possibilities for new sleep supplements featuring this essential mineral.

8.8

Reduced anxiety

Most Useful Review

Amazing! I purchased this for my wife, who previously used a more expensive brand. After switching to Now Foods Picolinate Zinc, she noticed significant improvements in her skin regarding hormonal break-outs and found it easier to swallow the capsules. She felt it helped with her anxiety and appetite control, as she is now more aware of when to stop eating. These zinc capsules have worked wonders for her without any side effects. I will definitely buy again!

Lung Cancer

Zinc's role in lung cancer treatment

Based on 4 Researches

The human zinc-binding cysteine proteome.

Most Relevant Research

We explored the role of zinc as an essential micronutrient that influences various physiological processes, particularly in the context of lung cancer. Our study focused on understanding how zinc binds to specific sites on proteins, especially cysteine residues, and how this binding affects cancer cell behavior.

Through a thorough mapping called ZnCPT, we identified a significant number of zinc-binding cysteines—6,173 in total. This mapping allowed us to uncover several protein families that are affected by zinc binding, either on a regular basis or when induced.

Importantly, we discovered that zinc could influence 52 genetic dependencies in cancer, pointing toward some malignancies that might be particularly sensitive to zinc's effects. In our findings, we observed a specific mechanism where zinc regulates the enzyme glutathione reductase (GSR). This regulation appears to drive cell death in certain lung cancers that rely on GSR, suggesting a potential avenue for future treatments.

Overall, while zinc shows promise in affecting lung cancer cells, further investigation will be essential to fully understand its therapeutic potential.

8.8

Effective treatment

Most Useful Review

Excellent! I chose this form of zinc for its effectiveness. After recovering from coronavirus, I took it with D3, B vitamins, and selenium. I quickly regained strength, my hair stopped falling out, and I felt less weak, despite having had 46% lung damage. I highly recommend it.

Obesity

Zinc improves prostate health in obesity

Based on 9 Researches

Zinc Attenuates Prostate Hyperplasia and Inflammatory Injury in Obese Rats by Regulating Zinc Homeostasis and Inhibiting the JAK1/STAT3 Pathway.

Most Relevant Research

We explored how zinc supplementation affects prostate health in obese rats, particularly in terms of prostate inflammation and cell proliferation. The study involved a well-structured experiment with control and treatment groups over eight weeks. Obese rats were given either zinc sulfate or a saline solution, allowing us to compare the effects of zinc directly.

Our findings revealed that obese rats experienced reduced sperm health and increased inflammatory markers in prostate tissue. Upon zinc supplementation, these rats showed improved sperm motility and count, alongside a notable reduction in inflammatory cytokines and insulin growth factors.

We observed significant changes in the expression of zinc transporters, which regulate zinc levels in the body, after supplementation. The results also indicated that zinc negatively affected the JAK1/STAT3 signaling pathway, which is often linked to inflammation and cancer, suggesting a potential mechanism by which zinc supports prostate health.

Overall, our study presents compelling evidence that zinc can be an effective tool in managing obesity-related prostate issues, highlighting its role in promoting healthier reproductive function in males.

8.8

Supports men’s hormones

Most Useful Review

Zinc picolinate is an inexpensive supplement that can help strengthen male hormones and prevent obesity. I recommend it.

Pneumonia

Effective during illness

Most Useful Review

This zinc is excellent for colds. My husband and I took it daily during our illness, and thankfully, we avoided pneumonia. I highly recommend zinc picolinate for effective recovery.

Prostate Cancer

Zinc's complex role in prostate cancer

Prostate cancer-selective anticancer action of an oxindole derivative via HO-1-mediated disruption of metabolic reprogramming.

Most Relevant Research

We explored the relationship between zinc levels and prostate cancer treatments, particularly focusing on a novel compound known as 3D. This compound showed a strong potential to target prostate cancer cells, contributing to a decrease in their proliferation rates.

Our analysis revealed that compound 3D selectively impacted key metabolic processes in prostate cancer cells by suppressing factors related to energy production, such as lactate levels. Interestingly, it also reduced the activity of transporters involved in zinc absorption while leaving those responsible for zinc export untouched.

We also found that the effectiveness of 3D could be reversed with zinc treatment, highlighting a complicated interaction between zinc and this therapeutic approach. While the compound successfully lowered zinc levels in cells and inhibited cancer growth, it is essential to note that we did not find significant benefits from zinc treatment by itself in the context of this study.

Overall, our findings suggest that targeting zinc metabolism and enhancing heme oxygenase-1 expression could be a promising strategy in prostate cancer therapy, more so than the direct application of zinc itself. The results illustrate the potential for combining innovative small molecules with an understanding of cancer metabolism in the development of treatment strategies.

8.8

Zinc benefits prostate

Most Useful Review

Zinc is essential for combating viruses like herpes and supports prostate health, playing a crucial role in preventing prostate cancer. It helps in protein synthesis and promotes healing; additionally, my skin and nails improved, and my cravings for sweets diminished. I highly recommend this zinc supplement.

Reflux

Relieved reflux symptoms

Most Useful Review

A nutritionist informed me that zinc can enhance gastric acid secretion. A deficiency in gastric acid may lead to malabsorption of trace elements, proteins, and vitamins, resulting in health issues. I experience reflux and decided to supplement with zinc picolinate, which the nutritionist recommended as the best option. After taking it for some time, my reflux has improved. I plan to continue this supplement to further boost gastric acid production and support my nutrition.

Shingles

Likely Ineffective

Zinc shows limited shingles benefits

Stimulation of specific immune response to varicella antigens in the elderly with varicella vaccine.

Most Relevant Research

In a double-blind study, we aimed to see how zinc treatments could influence the immune response to varicella-zoster virus, particularly in older adults. Thirty volunteers over the age of 70 received either the live varicella vaccine or a placebo after a four-week period where they were pretreated with zinc acetate or a placebo.

We noted that while the elderly participants initially showed a decreased response to varicella-specific antigens, their general skin reactivity to common bacterial antigens remained normal. However, after repeated skin testing, we observed that their varicella-specific responses became significantly stronger, making it difficult to isolate the effects of zinc or the vaccination.

Interestingly, we found no significant changes in the specific antibody levels across the groups, indicating that zinc's role in enhancing the immune response to shingles might be limited. Overall, it seems that the elderly population does retain the capability to respond to immunizations, but the speed at which that response occurs may slow down, which could be linked to the increased incidence of shingles in this age group.

9.5

Effective shingles relief

Most Useful Review

I prefer Zinc picolinate as it is an effective form of Zinc. I experienced a shingles flare-up and used it alongside VitD and K2 for several days, which helped remarkably within three days. I take it intermittently when I feel a cold, flu or similar illness coming on.

Sleep Apnea

Zinc protects heart function in OSA

Zinc Is Indispensable in Exercise-Induced Cardioprotection against Intermittent Hypoxia-Induced Left Ventricular Function Impairment in Rats.

Most Relevant Research

We explored how zinc affects heart function in the context of obstructive sleep apnea (OSA), specifically focusing on cases of intermittent hypoxia (IH). In a detailed study using male rats, researchers set up different groups: a control group and one that underwent 10 weeks of exercise training. Half of the rats in both groups were exposed to IH conditions to simulate the effects of sleep apnea.

The results were eye-opening. Rats that experienced IH showed notable impairment in their heart's left ventricular function, characterized by reduced ejection fraction and increased inflammation. However, when treated with zinc, these negative effects were significantly countered. Notably, those who exercised and received zinc treatment displayed improved heart function and antioxidant capabilities compared to their counterparts that did not receive zinc.

On the flip side, exercise alone did not provide the same protective benefits when zinc was absent. The findings suggest that zinc is essential not only for the heart's protection against the damaging effects of IH but also enhances the benefits of physical exercise. This research indicates the importance of zinc in potentially managing heart health in individuals suffering from sleep apnea.

9.5

Improved mood

Most Useful Review

I’ve been taking 1000 mg each night for over a month and have noticed significant changes. My mood has improved, my energy levels have increased, and I’m sleeping better than ever, which has positively affected my sleep apnea.

Tinnitus

Zinc intake affects tinnitus risk

The Association between Dietary Intakes of Vitamins and Minerals with Tinnitus.

Most Relevant Research

We examined how dietary intakes of vitamins and minerals, particularly zinc, could influence the onset and presence of tinnitus, a condition characterized by phantom sounds in the ears. In a study involving nearly 3,000 participants over the age of 50, we identified cases of tinnitus to determine if their dietary habits played a role in their experience of this condition.

The findings indicated that while there were no significant associations between overall vitamin and mineral intake and existing tinnitus prevalence, zinc intake stood out in relation to developing tinnitus over time. Specifically, we observed that lower zinc consumption was linked to a 44% increased risk of experiencing tinnitus over a ten-year period.

Furthermore, we noted that iron intake also showed a significant correlation, with lower iron levels raising incident tinnitus risk by approximately 35%. These results highlight the potential importance of maintaining adequate zinc and iron levels in our diets to help reduce the risk of developing tinnitus.

9.5

Tinnitus improved

Most Useful Review

Excellent zinc, which helped to raise my blood levels of this element and enhance my well-being! It also alleviated my tinnitus.

Asthma

Dietary zinc may reduce asthma

Association between dietary zinc intake and asthma in overweight or obese children and adolescents: A cross-sectional analysis of NHANES.

Most Relevant Research

We explored the relationship between dietary zinc intake and asthma in overweight or obese children and adolescents. This research utilized data from the National Health and Nutrition Examination Survey, focusing on those aged 20 and younger who had both asthma and dietary zinc consumption.

Our findings indicate that there is an inverse association between zinc intake and the occurrence of asthma. In simpler terms, higher dietary zinc appears to be linked with lower asthma rates in these children. This suggests that zinc could play an important role in respiratory health, especially for kids struggling with their weight.

While our study sheds light on this potential protective effect of zinc, we recognize that the results in existing literature have been mixed. Some research indicates benefits, while other studies don’t show significant effects. Therefore, while we have uncovered a correlation worth noting, further research is required to fully understand zinc’s role in asthma management.

9.5

Strengthened immunity

Most Useful Review

I've been using Now Foods Zinc Picolinate for about a year due to my asthma and frequent illness. Since taking it, I've only been ill once in the past year, as it has bolstered my immune system. I highly recommend this product!

Autoimmune Disorder

Zinc supplementation benefits MS models

Dietary zinc status is associated with ZnT3 (SLC30A3), IL-6 gene expressions and spinal cord tissue damage in spinal cord tissue in a cuprizone-induced rat Multiple Sclerosis model.

Most Relevant Research

We explored how dietary zinc levels influence spinal cord damage and gene expressions associated with Multiple Sclerosis (MS) using a cuprizone-induced rat model. The study included 46 adult male Wistar rats divided into five groups, with some receiving zinc supplementation while others followed a zinc-deficient diet.

After eight weeks of treatment, we found that the rats with MS symptoms showed elevated markers of tissue damage and inflammation, particularly in the groups that lacked zinc. Notably, those receiving zinc supplementation exhibited significantly reduced levels of harmful substances, bringing them back closer to control levels.

Our findings highlight zinc's protective effects in a model of MS, suggesting that incorporating zinc into treatment plans could help alleviate some symptoms associated with this autoimmune disorder. This is promising for future treatment strategies for those affected by MS.

9.5

Aids conception

Most Useful Review

I ordered zinc picolinate to improve my husband's sperm quality when we faced conceiving challenges. After three months of use with other vitamins, he had noticeable improvements. I recommend this supplement for those struggling with male-factor infertility; it worked for us when we wanted to conceive.

Blood Clot

Zinc enhances blood clot formation

Enhanced coagulation cascade activation and styptic effects of Zn@SiO nanocomposite.

Most Relevant Research

We explored how zinc affects blood clotting, particularly through a substance called Zn@SiO nanocomposite. This material shows promise as a hemostatic agent, which means it helps stop bleeding by promoting the formation of stable blood clots.

During our analysis, we examined various aspects of how this nanocomposite interacts with blood. It activates specific factors in the coagulation cascade—the process our bodies use to form clots. With the presence of zinc in the material, we observed enhanced activation of these factors, leading to improved clot formation.

Our research involved synthesizing and characterizing the Zn@SiO nanocomposite using several methods, including XRD, FTIR, and HRTEM. We also tested its effects on red blood cell aggregation, platelet adhesion, and several vital clotting time measures. The results indicate that Zn@SiO has significant hemostatic properties, showing potential for use in surgeries and trauma care.

This study highlights the exciting role of zinc in optimizing hemostasis, making it a candidate worth considering for medical applications related to bleeding management.

8.3

Immunostimulating effects

Most Useful Review

I take zinc as advised by my endocrinologist to support my thyroid alongside iodine and selenium. For the past three years, I have taken zinc for three months and then taken a break for 1.5 months. It is well tolerated, with no negative side effects. Since starting these supplements, herpes occurrences have significantly decreased, and I experience fewer colds. If I feel unwell, I increase my zinc intake for a few days, which helps prevent illness. I recommend this product but advise consulting a doctor or testing for blood clot levels.

Bronchitis

Zinc accelerates bronchiolitis recovery

Zinc sulphate for acute bronchiolitis: A double-blind placebo-controlled trial.

Most Relevant Research

We investigated the effectiveness of zinc sulphate in treating acute bronchiolitis in children, aiming to uncover whether this supplement could help speed recovery. In our study, we closely examined 100 young patients diagnosed with the condition. Half of the children received oral zinc sulphate while the other half received a placebo.

Over the course of the treatment, we compared the clinical signs and symptoms between the two groups at several intervals: 24, 48, 72, 96, and 120 hours after starting. Encouragingly, we observed that those in the zinc group showed a more favorable trend in recovery compared to the placebo group across all time points. Notably, significant differences were noted in improvements of coughing and wheezing at the 48 and 72-hour marks.

Remarkably, we found that 98% of the children who received zinc sulphate achieved full recovery within 72 hours of treatment—indicating a rapid response to the therapy. Our findings suggest that zinc sulphate can notably accelerate the improvement of clinical symptoms in acute bronchiolitis. Therefore, we feel confident recommending zinc sulphate as a helpful treatment option for this condition.

8.8

Improved immunity

Most Useful Review

At the first signs of a cold, I found zinc invaluable. It has been a part of our family’s regimen for years, especially as my eldest son previously suffered from severe illnesses, including bronchitis. Now, our family's health has significantly improved. I do divide the capsule for my children during illness and take it regularly during the cold season for prevention.

Bruise

Improved bruise healing

Most Useful Review

100% effective. It forms the primary component of a man's diet. It significantly enhances immunity, alleviates bruises, and tackles white spots on nails, and dark circles under the eyes.

Depression

Zinc deficiency impacts brain function

Proteomics analysis in rats reveals convergent mechanisms between major depressive disorder and dietary zinc deficiency.

Most Relevant Research

We aimed to uncover the connection between dietary zinc deficiency and symptoms associated with major depressive disorder (MDD). In our study, we used rats fed either a zinc-adequate diet or one deficient in zinc for four weeks.

We then analyzed the changes in protein expression in the prefrontal cortex and hippocampus—two brain areas closely linked to depression. This approach allowed us to see how zinc deficiency impacts the brain at a molecular level.

Our findings revealed that significant alterations occurred in proteins related to zinc transport and mitochondrial function due to the deficiency. In particular, we saw a notable decline in the activity of complex I of the mitochondrial energy production pathway in the prefrontal cortex.

These results suggest that low zinc levels can disrupt vital brain functions, potentially contributing to the development of depressive symptoms. This highlights the importance of maintaining adequate zinc levels for mental health.

9.5

Improves mood

Most Useful Review

I've been taking zinc picolinate for several months as a preventive measure against depression. It has helped me manage my anxiety and irritability due to stress, leaving me feeling calmer, more confident, and productive.

Eczema

Zinc enhances eczema recovery

Transient symptomatic zinc deficiency in an exclusively breastfed infant.

Most Relevant Research

We investigated the relationship between zinc deficiency and eczema in a 3-month-old infant who was exclusively breastfed. The infant presented with symptoms like scaling erythematous dermatitis affecting her face and other areas, alongside irritability and poor weight gain. Her mother had been taking isoniazid for tuberculosis during pregnancy, which possibly contributed to the infant’s zinc deficiency.

After initial treatments for a suspected skin infection didn’t bring any changes, we found that the baby had low serum zinc levels and low zinc concentration in her breast milk. This led us to believe the skin condition was due to zinc deficiency rather than an infection. We started zinc supplementation, and the infant showed remarkable improvement in her skin condition and weight.

By 6 months, the infant had begun eating solid food, and we stopped the zinc supplements, with no signs of eczema returning. This case underscores the importance of monitoring zinc levels in breastfed infants, especially when mothers are on specific medications that might impact nutrient transfer through breast milk.

8.8

Improved eczema health

Most Useful Review

I take it once every few days, as I believe it’s not good to take too much. It’s small and easy to swallow. My scalp eczema, which I’ve suffered for years, has improved, and I want to continue taking it.

Epilepsy

Zinc linked to epilepsy risk

Diet-derived circulating antioxidants and risk of epilepsy: a Mendelian randomization study.

Most Relevant Research

We explored the relationship between zinc and epilepsy by conducting a Mendelian randomization analysis. This study focused on understanding whether dietary zinc could potentially influence the risk of developing epilepsy. Our investigation involved looking into various antioxidants commonly found in the diet, such as selenium and vitamins A, C, and E, alongside zinc. However, we found that zinc was the only antioxidant linked to epilepsy risk.

Our analysis demonstrated that a genetic prediction of increased zinc was positively associated with several types of epilepsy, including general and focal types. Specifically, an increase in zinc levels was correlated with a higher likelihood of experiencing epilepsy. Yet, the other antioxidants we examined didn't show any significant effect on epilepsy risk.

These findings highlight the need for further research into zinc's role in epilepsy management. While zinc appears to have a direct relationship with epilepsy, the implications of using it as a treatment option still require careful consideration, especially since no other dietary antioxidants had a measurable effect.

8.8

Positive effect noticed

Most Useful Review

Absorbs well. This form of zinc is highly absorbent. I have taken it for acne and epilepsy as a supplement (it is recommended). So far, I believe it’s effective.

Erectile Dysfunction

Zinc improves erectile dysfunction

Effect of oral zinc therapy on gonadal function in hemodialysis patients. A double-blind study.

Most Relevant Research

We observed the effects of zinc on erectile dysfunction in a carefully designed study that involved a double-blind trial. Twenty stable hemodialysis patients participated, receiving either 50 mg of zinc as zinc acetate or a placebo for six months. The goal was to determine if zinc could enhance gonadal function, especially in men who often experience hormonal issues due to kidney problems.

At the end of the study, we noted significant improvements in the zinc-treated group compared to the placebo group. Those receiving zinc had a remarkable increase in plasma zinc levels, testosterone levels, and sperm counts. Specifically, testosterone levels rose from 2.8 to 5.2 ng/mL, and sperm counts doubled from 30 to 63 million/mL, indicating a marked improvement in reproductive health.

Not only did these participants show increased hormone levels, but they also experienced a noticeable drop in luteinizing hormone and follicle-stimulating hormone, suggesting improved gonadal function. Alongside these biochemical changes, many reported better potency, enhanced libido, and increased frequency of intercourse, highlighting zinc’s role in reversing some aspects of erectile dysfunction related to zinc deficiency.

In conclusion, our findings suggest that zinc deficiency can be a reversible factor contributing to erectile dysfunction in hemodialysis patients, offering hope for those struggling with this issue.

8.3

Improved erectile dysfunction

Most Useful Review

Taking zinc dietary supplements throughout the year helps to maintain proper levels in the body and addresses issues from skin problems to memory enhancement. It's vital for those over 40, aiding metabolism and preventing erectile dysfunction in men, while also easing transitional menopause in women. Since suffering from COVID-19, my doctor advised me to take zinc, which strengthens the immune system. Zinc in picolinate or citrate form is best absorbed.

Hives

Zinc insulin alleviates hives

Chronic urticaria from isophane insulin therapy; sensitivity associated with noninsulin components in commercial preparations.

Most Relevant Research

We observed a fascinating case of a young woman with diabetes who experienced chronic hives after switching her insulin type. Initially, she moved from a standard isophane insulin to a beef-pork version, which then triggered her hives. Even after she returned to her original insulin, the hives continued to be a problem.

During her hospital stay, we noted that her hives reappeared daily after insulin injections. This situation changed when we introduced a purer form of insulin called zinc single-peak beef insulin suspension. Surprisingly, the urticaria cleared up quickly after this switch.

Through skin testing, we discovered her sensitivity was primarily to the beef and pork forms of the isophane insulin. However, she showed no sensitivity to the zinc insulin forms. Although she did experience a brief return of the hives after taking antibiotics, this time they did not reappear at the insulin injection sites.

This case provides valuable insight into how certain insulin components can lead to hives, and how switching to a zinc preparation offered the young woman some relief.

8.8

Hives treatment success

Most Useful Review

I always seek ways to enhance my immune system, especially after experiencing Epstein Barr Syndrome, which left me drained. I researched supplements for boosting energy and health and discovered that Zinc Picolinate is beneficial. I take one 50mg gel cap daily, and I've noticed improvement in the rough hive spots that were struggling to heal. Zinc is known for its wound-healing properties. I’m pleased with this high-quality product from iHerb, and I always take it with food to be cautious.

Hypothyroidism

Zinc's uncertain role in hypothyroidism

The Effect of Some Micronutrients Multi-Supplementation on Thyroid Function, Metabolic Features and Quality of Life in Patients Treating With Levothyroxine and Vitamin D: A Double-blind, Randomized Controlled Trial.

Most Relevant Research

We conducted a study to investigate the effects of micronutrient supplementation, including zinc, on thyroid function and overall quality of life in patients with hypothyroidism. Our trial involved 104 participants who were receiving levothyroxine and vitamin D. They were randomly assigned to either a group that received a mix of essential nutrients or a placebo group over eight weeks.

We measured various health markers before and after this period, including thyroid hormone levels, cholesterol, insulin resistance, and blood pressure. Our findings suggested that the group receiving the micronutrient supplement experienced improvements in insulin resistance and overall quality of life. However, it’s important to note that the specific effects of zinc alone are somewhat difficult to isolate, as it was part of a combination of nutrients being tested.

Ultimately, while the study indicates potential benefits of micronutrient supplementation for thyroid function in hypothyroid patients, further trials are necessary to clearly define the role of zinc and other nutrients in this context.

9.5

Replenished zinc levels

Most Useful Review

Excellent zinc in a good form! The results are positive. I have hypothyroidism and require zinc supplementation. It’s also beneficial for hair, skin, nails, and boosts immunity!

Leg Cramps

Zinc Picolinate has been beneficial for my condition, Pyroluria. After switching from "NOW" zinc supplements, I experienced better absorption and have not suffered from leg cramps that I previously endured.

Psoriasis

Zinc conditioner benefits scalp psoriasis

Efficacy and safety of supramolecular active zinc in the treatment of scalp psoriasis: a multicentre, randomized, observed-blind, parallel-group, placebo- and active-controlled noninferiority trial.

Most Relevant Research

We delved into the effectiveness of a zinc-based hair conditioner specifically designed for treating scalp psoriasis. This study was a well-structured clinical trial involving 211 participants, where individuals were divided into three groups: those receiving the specialized zinc treatment, a placebo, and a control group given calcipotriol ointment. Remarkably, the trial was multicenter and observed-blind, which adds credibility to the findings.

Our results revealed that the zinc conditioner led to a 39% disease control rate after four weeks, compared to 25% for the placebo and 37% for the calcipotriol ointment group. This means that the zinc treatment significantly outperformed the placebo while being on par with the active control variant. In essence, those using the zinc product experienced better management of their scalp psoriasis than those using a non-active alternative.

Overall, our findings highlight that a supramolecular active zinc antidandruff formulation is not just effective for treating scalp psoriasis but also helps in maintaining results over time and potentially preventing future flare-ups. This offers a promising new avenue for patients seeking relief from this chronic condition.

9.5

Psoriasis relief

Most Useful Review

I've taken zinc for three years; it's been instrumental for my psoriasis management. During flare-ups, I take a daily tablet, and the itching and redness have drastically reduced, with several spots cleared up completely.

Allergies

Zinc may relieve allergy symptoms

Alleviating effect of intranasal zinc on symptoms of allergic rhinitis.

Most Relevant Research

We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.

Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.

The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.

Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.

9.5

Skin condition improvement

Most Useful Review

I bought these pills for my atopic dermatitis. After struggling with various treatments, I tried zinc picolinate, as it’s better absorbed. Amazingly, the itching has now gone, and my skin is no longer dry. My husband even remarked on how delicate my skin looks!

Diabetes

Zinc alleviates diabetic muscle atrophy

Zinc Alleviates Diabetic Muscle Atrophy via Modulation of the SIRT1/FoxO1 Autophagy Pathway Through GPR39.

Most Relevant Research

Our investigation aimed to understand how zinc affects muscle atrophy in diabetes, a serious complication that leads to muscle loss. Using diabetes-induced mice, we treated them with zinc sulfate for six weeks and observed notable improvements in their muscle condition.

We conducted various analyses to evaluate the impact of zinc on autophagy—the process that helps manage muscle mass. The results were promising; zinc appeared to enhance muscle recovery by regulating specific molecular pathways connected to muscle health.

Additionally, our in vitro studies with diabetic muscle cells revealed similar results, with zinc supplementation proving beneficial in reducing excessive autophagy. Overall, this suggests that incorporating zinc into treatment plans could be a promising approach to counteract muscle deterioration in diabetic patients.

9.5

Supports diabetes management

Most Useful Review

This supplement significantly improved my health regarding diabetes in just a month. I plan to repurchase as it's greatly helped me manage my condition.

Irritable Bowel Syndrome

Likely Ineffective

Zinc intake may reduce IBS risk

Dietary copper, zinc, copper/zinc ratio intakes and irritable bowel syndrome risk: a large-scale prospective cohort study from UK Biobank.

Most Relevant Research

We explored the potential connection between dietary zinc intake and the risk of developing irritable bowel syndrome (IBS) through a large-scale analysis of participants from the UK Biobank. By assessing the dietary habits of 175,421 individuals who did not have IBS at the start of the study, we sought to understand how various levels of zinc, as well as copper and their ratio, might influence the onset of this troublesome condition.

Over an average follow-up period of 13.3 years, we observed that 2,240 participants were diagnosed with new-onset IBS. Notably, our findings revealed a U-shaped relationship between zinc intake and IBS incidence. For those consuming less than 10 mg of zinc per day, an increase in intake was linked to a decreased risk of IBS. Specifically, individuals taking less than 10 mg of zinc daily experienced a reduced risk with higher zinc consumption.

However, the relationship shifted for individuals who had higher intakes of copper and zinc; no significant benefits were noted when intakes reached or exceeded established thresholds. This suggests that there's a delicate balance to maintain when it comes to zinc and copper in the diet.

Importantly, subgroup analysis indicated that younger individuals, particularly those under 60, could benefit more from slight increases in zinc. Overall, our study highlights the significance of dietary management, emphasizing that reasonable zinc intake may contribute to lowering IBS risk while keeping copper and the copper/zinc ratio in a sensible range.

Improved immune system

Most Useful Review

Excellent zinc! I’ve been using it for about a month and noticed positive changes. It has calmed my nerves, and I’ve even lost my craving for sweets. My hair loss has decreased, skin condition improved, and nails strengthened. While I cannot speak on all fronts, I take it after meals to avoid nausea. The capsule is small, easy to take, and I appreciate the quality and reasonable price from iHerb.

The Effectiveness of a Dietary Supplement with Honey, Propolis, Extract, and Zinc in Children Affected by Acute Tonsillopharyngitis: An Open, Randomized, and Controlled Trial.

Most Relevant Research

This study took a closer look at the effects of a dietary supplement, PediaFlù, which includes honey, propolis, and zinc, on children suffering from acute tonsillopharyngitis, a common throat infection. We explored how well this supplement worked alongside standard care compared to standard care alone over six days.

The results were quite encouraging! We found that children who received the supplement alongside standard treatment reported lower throat pain and erythema (redness of the throat) by day six. There were also improvements in swallowing and overall throat severity scores by days four and six. Interestingly, only one child in the standard care group needed additional treatment with ibuprofen, suggesting that the supplement may help alleviate symptoms effectively.

However, it's important to note that while zinc was part of this combination treatment, the study focused on the overall effect of all components together. We couldn't isolate zinc's individual impact on tonsillitis specifically. That said, the findings point to the possibility of using this dietary supplement as a helpful adjunct in treating upper respiratory tract infections, which may reduce unnecessary antibiotic use in pediatric care.

9.5

Stronger nails

Most Useful Review

I didn't expect much, mainly wanting to reduce the frequency of tonsillitis episodes. However, my hair has stopped falling out, now shining beautifully. My nails, which often broke, have become stronger and are growing quickly.

Cardiovascular Disease

Zinc counters heart cell injury

Zn protects H9C2 cardiomyocytes by alleviating MAMs-associated apoptosis and calcium signaling dysregulation.

Most Relevant Research

We set out to investigate how zinc might help protect heart cells from damage caused by a lack of blood flow, known as myocardial ischemia-reperfusion injury (MIRI). Using H9C2 cells, which are derived from rat heart tissue, we simulated this injury by depriving these cells of oxygen and then reintroducing it while treating them with zinc.

Through this process, we found that zinc treatment significantly increased cell viability compared to those that did not receive zinc. Cells exposed to ischemia showed typical signs of trauma, like heightened levels of apoptosis—or programmed cell death—and calcium overload, which can further damage cells.

Interestingly, zinc seemed to tackle these issues by lowering the levels of certain proteins related to cell death. It also played a role in regulating calcium levels by interacting with various cellular pathways. In fact, when we silenced specific proteins involved in these pathways, the protective benefits of zinc were even more pronounced.

Our findings suggest that zinc can relieve the harmful effects of ischemia by mitigating cell death and regulating calcium overload, which offers hope for future treatments for heart-related conditions impacted by blood flow interruptions.

Energy and vitality

Most Useful Review

Customers frequently commend the NOW CoQ10 supplement for its quality, effective ingredients, and positive effects on energy levels. Many users report notable increases in energy, helping them manage busy days better. It's also recognised for its benefits in relation to cardiovascular disease.

Chronic Fatigue Syndrome

Zinc supplementation may benefit CFS

Lower serum zinc in Chronic Fatigue Syndrome (CFS): relationships to immune dysfunctions and relevance for the oxidative stress status in CFS.

Most Relevant Research

We explored the relationship between serum zinc levels and chronic fatigue syndrome (CFS) in a study that compared patients with CFS to normal volunteers. By using an atomic absorption method, we measured serum zinc concentrations and found that those suffering from CFS had significantly lower levels of zinc compared to healthy individuals.

Interestingly, we observed a trend indicating that lower zinc levels correlated with greater CFS severity. Patients also reported a negative correlation between their zinc levels and their subjective experiences of infection. This suggests that zinc plays a role in the immune dysfunction commonly seen in CFS.

Furthermore, we noted that lower serum zinc was associated with higher levels of inflammatory markers and certain defects in the early activation of T cells. Since zinc acts as a potent antioxidant, our findings indicate that CFS is linked to increased oxidative stress in these patients. Given this, it may be beneficial for some CFS patients to consider zinc supplements as part of their treatment approach.

9.5

Zinc improves wellbeing

Most Useful Review

This zinc is fantastic! After a month of use, I've experienced positive changes, especially regarding my chronic fatigue syndrome. My anxiety has lessened, cravings decreased, and my skin and nails have improved significantly. I feel healthier overall!

Ulcer

New treatment reduces digital dermatitis

Based on 10 Researches

Investigation on the effectiveness of a new hoof care product to sustainably reduce and prevent digital dermatitis in dairy cow herds.

Most Relevant Research

We embarked on an investigation to understand whether a new hoof care product featuring iron, zinc, and aluminum can effectively reduce and prevent digital dermatitis (DD) in dairy cows. In a controlled trial involving over 130 dairy cows, we treated one hind foot of each cow twice a week with this product while leaving the other foot untreated for comparison.

The results were revealing! Our analysis indicated that the use of the hoof care product significantly reduced the severity of DD compared to the untreated group. In fact, cows treated with the product had a much lower chance of developing lesions. The outcome showed that in the control group, the odds of having a lesion were four times higher than in the treated group, and the likelihood of experiencing an active lesion versus an inactive one was even more pronounced.

Interestingly, we also observed positive outcomes in heifers, with only one developing an active lesion in the treated group, showcasing the potential for this product to help manage and prevent DD even before these young cows enter the herd. The study indicates that the combination of ingredients in this hoof care product could be a promising alternative to traditional, harsher treatments.

While zinc is included as one of the components in the product, it's essential to note that we can't isolate its effect on ulcers from the other ingredients. Therefore, we can't definitively conclude zinc's sole effectiveness when it comes to DD treatment, but the overall findings are encouraging for improving hoof health in dairy cows.

9.5

Ulcer improvement noted

Most Useful Review

After starting this product due to my zinc deficiency and mouth ulcers, I noticed my ulcers subsided within a week. I'm thrilled with the results!

Hashimoto

Zinc's link to Hashimoto's thyroiditis

Association Between Essential Trace Elements and Thyroid Antibodies in the Blood of Women with Newly Diagnosed Hashimoto's Thyroiditis.

Most Relevant Research

We explored the connection between essential trace elements, particularly zinc, and Hashimoto’s thyroiditis (HT) in women who were newly diagnosed. In this study, we looked at a group of 56 women with HT and compared them to 64 matched controls.

The results showed that women with HT had significantly lower levels of selenium, iron, and zinc in their blood compared to the controls. Interestingly, their copper levels were higher. We examined the relationships between these trace elements and thyroid autoantibodies, which can indicate the presence of autoimmune activity affecting the thyroid.

While we noted a significant correlation between lower zinc (and other elements) and higher levels of thyroid antibodies, the study did not specifically focus on zinc treatment. This means that while zinc levels appear to be linked to autoantibody levels in HT, we can't definitively state that zinc treatment will improve the condition without further dedicated research.

Overall, the study indicates that lower zinc levels in conjunction with selenium and iron deficiencies might be involved in the autoimmune response seen in Hashimoto’s thyroiditis. Thus, this provides an avenue for future exploration into zinc's role as a potential supplement for women diagnosed with this condition.

9.5

Improves cold tolerance

Most Useful Review

This excellent drug is well absorbed. When I catch a cold, I find I endure it easily. I have Hashimoto's, hypothyroidism, and I require zinc continually.

Menopause

Zinc enhances vitamin D in menopause

Effectiveness of eight-week zinc supplementation on vitamin D status and leptin levels in a population of postmenopausal women: a double-blind randomized trial.

Most Relevant Research

We set out to understand how zinc supplementation could affect vitamin D status and leptin levels in postmenopausal women. The study involved 51 healthy postmenopausal women aged between 44 and 76 from Granada, Spain. They were divided into two groups: one receiving a zinc supplement of 50 mg daily for eight weeks and the other receiving a placebo.

Our findings revealed that zinc supplementation significantly improved vitamin D status in these women. Particularly, those who had reached menopause at a younger age saw a notable increase in their vitamin D levels after taking zinc.

Additionally, we discovered a connection between zinc and leptin levels, a hormone that regulates energy balance. Both dietary zinc intake and its plasma levels were found to be inversely related to serum leptin levels—meaning as zinc levels increased, leptin levels tended to decrease.

Overall, these results suggest that zinc supplementation may play a beneficial role during menopause by enhancing vitamin D levels and influencing leptin balance among postmenopausal women.

8.8

Energy boost

Most Useful Review

As a 63-year-old male, I began taking this due to a decline in energy and male function, which I attribute to menopause. The capsules are easy to swallow, and I noticed immediate effects. I have been using them daily since their arrival, and the packaging is compact.

Bone Pain

It appears tongue pain occurs when zinc is deficient, but it works quickly for my occasional tongue pain. I take it before bed, and the pain subsides by morning.

Heartburn

Zinc's role in heartburn relief

Esophageal ulcer related to zinc deficiency following a total gastrectomy.

Most Relevant Research

We investigated how zinc affects heartburn through the case of a 76-year-old Japanese man who experienced significant discomfort after undergoing a total gastrectomy. For two weeks, he suffered from a sore throat, heartburn, and difficulty swallowing. Endoscopy revealed deep, craterlike ulcers in his esophagus, but tests for viral infections were negative.

After initial treatment, his symptoms returned, prompting further investigation. Eventually, we found that his serum zinc level was low at 38 µg/dL, which led to a diagnosis of zinc deficiency. Following oral zinc supplementation, the patient reported relief from his symptoms and a noticeable improvement in the esophageal ulcers observed during a follow-up endoscopy.

Over the five years since his treatment, the patient has continued to take zinc supplements and has not faced similar issues again. This case suggests that zinc can play a crucial role in treating heartburn issues related to ulcers, especially in those with a deficiency.

Supports wound healing

Most Useful Review

A must for wound healing. After extensive research, I chose picolinate and have no regrets. It alleviates heartburn and is essential for those with a compromised immune system, alongside vitamin C like sodium ascorbate powder.

Nausea

Zinc treatment reduces nausea risk

Based on 4 Researches

Randomized, multicenter, active-controlled open-label study of NPC-25, zinc histidine hydrate, (non-inferiority to NOBELZIN™, zinc acetate dihydrate) for patients with hypozincemia.

Most Relevant Research

We conducted a study to evaluate how effective NPC-25, a new form of zinc, is compared to a well-known treatment, NOBELZIN™, for patients with low zinc levels. Participants in this trial had their zinc levels checked and were grouped to receive either NPC-25 or NOBELZIN™.

For a period of up to 24 weeks, we aimed to maintain their zinc levels within a specific target range while closely monitoring for side effects. One of our main goals was to see if NPC-25 could maintain these target zinc levels similarly to NOBELZIN™.

Our findings revealed that NPC-25 was indeed non-inferior to NOBELZIN™, meaning it worked just as well. Importantly, we also observed that those taking NPC-25 reported fewer digestive issues, like nausea and vomiting. This suggests that while both treatments were effective, NPC-25 might be the gentler option.

9.5

No nausea experienced

Most Useful Review

This zinc is exceptional and far better than the expensive duds sold in pharmacies. I experienced no nausea or stomach pain with this product, unlike others. I recommend taking it during meals, and I've noticed positive effects on my skin and hair. Just avoid taking it with calcium for best results.

Anemia

Zinc deficiency linked to anemia

Zinc Deficiency Presenting With Diverse Symptoms in a Young Patient: A Case Report.

Most Relevant Research

We explored the connection between zinc deficiency and anemia through the case of an 18-year-old woman who faced a series of health issues, including urinary tract infections and insulin dysfunction. After a thorough assessment, she was diagnosed with zinc deficiency, shedding light on how this overlooked issue can impact overall health.

What stood out to us was the rapid recovery the patient experienced after beginning oral zinc supplementation. Zinc plays a critical role in numerous bodily functions, including immune support and protein regulation. By addressing her deficiency, we observed significant improvement in her symptoms, including anemia.

The patient’s diet contained high levels of substances that were inhibiting her zinc absorption, which likely contributed to her condition. This case emphasizes the importance of recognizing zinc deficiency as a potential underlying cause for unexplained health issues, particularly anemia. Prompt diagnosis and treatment can lead to a complete turnaround in the patient's health.

By sharing this experience, we hope to raise awareness among clinicians about the vital role of zinc in managing anemia and encourage timely interventions for patients showing diverse symptoms.

8.8

Improved immunity

Most Useful Review

One of the best forms of zinc. The capsule size is average and easy to swallow. I noticed significant improvements; my hair grows faster, my skin looks healthier, and my sebum production has decreased. Additionally, my immunity has enhanced, and I no longer catch colds from my sick child. However, it's essential not to overdo it, as too much zinc can lead to copper deficiency and subsequent anaemia.

Dizziness

Zinc's limited effect on dizziness

Prevention of Recurrent Benign Paroxysmal Positional Vertigo: The Role of Combined Supplementation with Vitamin D and Antioxidants.

Most Relevant Research

This study examined the effectiveness of a nutritional supplement containing zinc, among other ingredients, in preventing the recurrence of benign paroxysmal positional vertigo (BPPV), a condition that can cause intense dizziness. We followed a diverse group of 128 patients with a history of frequent BPPV episodes. They were divided into three groups based on their vitamin D levels and received different treatment plans.

In one group, those with low vitamin D received a daily supplement containing zinc, along with other antioxidants and vitamin D3. We noticed a remarkable decrease in BPPV relapses in this group after six months compared to where they started. However, for the groups that had sufficient vitamin D and particularly those receiving zinc without vitamin D, we did not find significant benefits in reducing dizziness recurrence.

While zinc was part of a combined treatment approach, it didn’t demonstrate a standalone positive impact on dizziness. Our findings suggest that while zinc might play a role alongside other supplements, it shouldn't be solely relied upon for preventing BPPV relapses in patients with sufficient vitamin D levels.

9.5

No dizziness

Most Useful Review

This zinc works excellently! Despite many colleagues having a cold, I remain healthy. Importantly, my husband did not experience nausea or dizziness, which is unusual for him. Zinc is vital for men, boosting testosterone levels and overall health—essential for maintaining immunity. He’ll continue to take this one. I highly recommend it!

Urinary Tract Infection

Zinc-Infused Catheters Reduce Infections

Antimicrobial and Antibiofilm Activities of Urinary Catheter Incorporated with ZnO-Carbon Nanotube.

Most Relevant Research

We investigated the potential of a new type of urinary catheter to tackle catheter-associated urinary tract infections (CAUTIs). By incorporating zinc oxide-carbon nanotubes (ZnO-CNT) into a silicone catheter, we explored how this innovative design could inhibit infection-causing bacteria effectively.

Utilizing a combination of laboratory techniques like scanning electron microscopy and dynamic light scattering, we analyzed the structure of our ZnO-CNT catheter, which showed promising antibacterial properties. Notably, we found that the ZnO-CNT infusion significantly reduced biofilm formation—one of the main challenges in urinary catheters—demonstrating up to 56% inhibition in bacterial growth compared to standard silicone catheters.

The study revealed that ZnO-CNT not only holds antimicrobial potential but may also provide a more comfortable alternative to existing metal-coated options, like those using silver or gold. With our findings, we hope to present a viable strategy for reducing the discomfort and risks associated with traditional catheters while addressing a prevalent healthcare concern.

Severe side effects

Most Useful Review

I experienced a dangerous dosage after taking one capsule daily for two weeks, leading to severe urinary tract infection and diarrhoea. This supplement contains almost five times the recommended daily intake of zinc for an adult woman (8 mg). Please exercise caution!

Back Pain

Zinc may boost bone density

Treatment for osteoporosis in people with beta-thalassaemia.

Most Relevant Research

We explored how zinc supplementation might help with back pain in individuals with beta-thalassaemia. The research included a randomized controlled trial with 42 participants, where some received zinc while others were given a placebo.

Results showed that zinc supplementation likely increased the bone mineral density (BMD) at the lumbar spine and hip after 12 to 18 months of treatment. This improvement in bone health could suggest potential benefits in pain relief, although the study didn’t directly measure back pain outcomes.

Even though the findings about BMD improvements are promising, we should be cautious. The trial didn't provide direct evidence on whether zinc specifically alleviates back pain. It’s essential to recognize that while we observed positive changes in bone density, interpreting this as a definitive solution for back pain would be premature.

Thus, further research is necessary to connect zinc's effects on bone health to actual pain relief in order to offer clearer guidance on its use as a treatment for back pain.

Great improvement

Most Useful Review

I took this vitamin alongside others for my father, who experienced a significant improvement, particularly regarding back pain, stress, and fatigue. After researching, I found the ingredients to be of high quality. May everyone enjoy good health.

Liver Disease

Zinc's Role in Liver Health

Genetic inactivation of zinc transporter SLC39A5 improves liver function and hyperglycemia in obesogenic settings.

Most Relevant Research

We focused on the connection between zinc and liver health, particularly how it may influence conditions like non-alcoholic fatty liver disease (NAFLD) and metabolic issues, including type II diabetes (T2D). Our analysis of data from a large genetics cohort revealed a significant finding: rare genetic variants that reduce the function of the zinc transporter SLC39A5 were linked to better metabolic profiles and lower T2D risk.

To delve deeper into these results, we used both laboratory and animal models. We developed mice that completely lacked SLC39A5 and observed promising outcomes. These mice showcased improved liver function and lower blood sugar levels after being subjected to obesity challenges, whether congenital or diet-induced.

Notably, this improvement seemed to be associated with increased levels of zinc in the liver, which activated key signaling pathways involved in metabolism, such as AMPK and AKT. Furthermore, these mice exhibited less liver inflammation and fibrosis in models of diet-induced non-alcoholic steatohepatitis (NASH).

Together, these findings position SLC39A5 as a potentially valuable target for treating liver-related metabolic disorders, emphasizing zinc's crucial role in managing liver health and blood sugar regulation.

9.5

Effective during illness

Most Useful Review

For a year, I’ve taken this zinc as advised by a trichologist, and I’m pleased with the results, particularly during the coronavirus period. My relatives now take it too. When unwell, it helps me recover from illness rapidly, including concerns related to liver disease.

Food Poisoning