Doctor&#039;s Best Nattokinase

Nattokinase optimizes cancer therapy

Based on 3 Researches

Nattokinase-Mediated Regulation of Tumor Physical Microenvironment to Enhance Chemotherapy, Radiotherapy, and CAR-T Therapy of Solid Tumor.

Most Relevant Research

We looked into the role of nattokinase, a health supplement known for its ability to dissolve blood clots, in improving treatments for solid tumors. The research focused on how nattokinase can modify the tumor's physical environment to boost the effectiveness of various cancer therapies, including chemotherapy, radiotherapy, and CAR-T cell therapy.

Through intratumoral injections of nattokinase, we found that it breaks down fibronectin, a key component of the tumor's dense extracellular matrix. This process reduces the tumor's stiffness, improves blood flow, and helps alleviate hypoxia—essentially allowing more oxygen and therapeutic agents to reach the tumor. As a result, chemotherapy becomes more effective without causing additional side effects.

Furthermore, we saw that when nattokinase was administered before radiotherapy, it increased the oxygen levels within the tumor, enhancing the responsiveness to radiation. In experiments with a human breast cancer model, the use of nattokinase also fostered better infiltration of CAR-T cells, which are designed to target and kill cancer cells.

These findings suggest that nattokinase is not just a passive health supplement but an active player in transforming the tumor environment to make cancer treatments more successful. Overall, our exploration shows great promise for nattokinase in optimizing cancer therapies, showcasing its potential for widespread application in fighting solid tumors.

9.5

Blood thickness improvement

Most Useful Review

It's working! My husband has a rare blood cancer (polycythemia vera) that makes his blood too thick. He was having a pint of blood taken every two weeks. I researched options and started him on several supplements. After six weeks, the doctor hasn't had to draw any blood. We'll continue this treatment.

Nattokinase (Bac s 1), a subtilisin family serine protease, is a novel allergen contained in the traditional Japanese fermented food natto.

Most Relevant Research

We examined the effects of nattokinase, a protease found in natto, on allergies. Our study involved eight individuals who experienced allergic reactions after consuming natto, specifically the sticky substance surrounding the beans. Some participants tested negative for polygamma glutamic acid (PGA), which was previously identified as a potential allergen.

Throughout our investigation, we employed skin prick tests, immunoblotting, and ELISA to assess the reactivity to nattokinase and other components. Notably, we discovered that a subset of patients, particularly those who were negative for PGA, exhibited an allergic response to nattokinase. This finding suggests that nattokinase may act as a distinct allergen in certain individuals.

In the end, we identified nattokinase as a new allergen linked to natto allergy, particularly in those not sensitized to PGA. While our study highlights the allergenic potential of nattokinase, its broader implications for allergy treatment remain to be fully explored.

8.8

Sinuses opened

Most Useful Review

Shockingly, this is opening my sinuses! I've ordered a second bottle. Spring/Summer allergies here in Las Vegas are challenging, but this product seems to open my sinuses and helps me breathe better.

Back Pain

It works wonders! After taking two capsules morning and night for two weeks, the persistent pain on the left side of my neck disappeared. My mum also noticed relief from her varicose veins.

Chest Pain

Clot dissolution success

Nattokinase dissolved my leg clots in just 11 days. Initially sceptical due to my doctor’s warnings about alternative treatments, I experienced a severe allergic reaction to Lovenox shots. Once I started Nattokinase, my clots vanished, and my blood pressure significantly improved. I take it on an empty stomach and truly believe it worked for me.

Chronic Fatigue Syndrome

Nattokinase was incredibly helpful for my chronic fatigue syndrome and hypotension, quickly raising my blood pressure and reducing the noise in my head.

Dizziness

Dizziness improvement

I ordered it for my husband alongside a neuro optimizer. He constantly experienced dizziness and a heavy feeling in the back of his head. After a week of taking these drugs, the dizziness and heaviness disappeared, along with improved clarity and mood. He takes the drug as directed and is very pleased! Thank you, iHerb!

Heart Attack

Nattokinase shows promise for hearts

Exploring the In Vitro Thrombolytic Activity of Nattokinase From a New Strain Pseudomonas aeruginosa CMSS.

Most Relevant Research

We aimed to explore the effectiveness of nattokinase, an enzyme with potent fibrinolytic properties, in treating heart attacks. Through our research, we focused on enhancing the production of nattokinase from a newly identified strain of Pseudomonas aeruginosa, referred to as CMSS, which we isolated from cow milk.

Our comprehensive study involved optimizing different growth conditions such as pH, temperature, and nutrient sources, alongside improving the strain through UV-mutagenesis. We were excited to find that these optimizations led to a significant increase in nattokinase production.

The standout results showed that our modified strain produced nattokinase with a maximum activity of 4263 U mL(-1), which is double that of the original strain. In practical terms, this nattokinase achieved an impressive 94% blood clot lysis within ten minutes, hinting at its potential as a rapid acting treatment for heart-related issues.

Overall, our findings suggest that nattokinase from Pseudomonas aeruginosa CMSS could be a promising candidate for thrombolytic therapy, notably for those at risk of acute myocardial infarction. This unique study represents the first report of nattokinase production from this microorganism, opening the door to further research.

9.5

No further heart attacks

Most Useful Review

I learned about nattokinase after my father was diagnosed with heart problems, having suffered a heart attack. We consulted his physician and switched to natural treatment with nattokinase. After a year, his blood circulation improved, and he hasn't had any further heart attacks. This truly is essential for heart patients.

Migraine

Works well. After struggling with clots and a permanent migraine for three months, taking three natto daily for just a few days eliminated my seemingly permanent migraine. I couldn't believe the difference.

Angina

Nattokinase has changed my life. For years, I took daily aspirin but still experienced angina when working. After starting nattokinase for another issue, I could work double the time without any angina the very next day. It has replaced aspirin and has been beneficial for the last four years without any side effects.

Bone Pain

I've been using nattokinase for over a month now since my legs started swelling and aching after the coronavirus. Thankfully, the pain and swelling have disappeared. I wish I had known about this sooner; it has significantly improved my leg discomfort and blood circulation. I recommend it for better blood flow!

Common Cold

I've struggled with poor circulation and cold feet, even in warm weather. After switching from Norvasc to this product, I no longer have cold feet. It may also be helping my backache.

Headache

Nattokinase is remarkable. It cured my hemorrhoids in ten days. This supplement surpasses others such as Detralex and Venarus. I recommend it to women suffering from menstrual pain and headaches; they’ll notice the difference when they start taking it 10 days before their period.

Knee Pain

Effective for arthritis

Best supplement for joint pain! I've taken Nattokinase, Serrapeptase, and Bromelain three times daily away from food, and they’ve become essential in managing my rheumatoid arthritis. My knee pain diminished after a couple of weeks of use. Highly recommend!

Stroke

Nattokinase promotes stroke recovery

Nattokinase Promotes Post-stroke Neurogenesis and Cognition Recovery via Increasing Circulating Irisin.

Most Relevant Research

We explored how nattokinase, a serine protease derived from the traditional food natto, can benefit individuals who have experienced strokes, particularly focusing on cognitive recovery. Our study specifically aimed to uncover whether nattokinase can act as an anti-post-stroke cognitive impairment (PSCI) agent by influencing blood factors that are crucial for brain health.

The results were telling. We discovered that nattokinase has protective effects against acute ischemic strokes and plays a significant role in promoting neurogenesis, which is the process of generating new brain cells. Through experiments conducted on rat models, we observed that nattokinase notably increases irisin levels in peripheral blood. Irisin is a protein that has emerged as an interesting player in enhancing cognitive functions.

By linking the increased levels of irisin to improved cognitive abilities, our findings suggest that nattokinase could be a promising therapy for those suffering from PSCI, positioning irisin as a potential target for treatment. Overall, our research highlights the exciting possibilities that nattokinase offers in the realm of stroke recovery and brain health.

9.5

Hydrates blood effectively

Most Useful Review

I use nattokinase instead of aspirin for thick blood, enhancing its fluidity. High blood viscosity poses a risk for strokes, hence I take it in the evening and on an empty stomach in the morning. It helps me forget my blood pressure issues!

Autoimmune Disorder

Blood thinner effective

Great natural blood thinner. My father struggled with thick blood due to cholesterol and an autoimmune disorder. He developed diabetes after Covid, worsening his condition. After trying various blood thinners, I ordered him this well-rated Nattokinase supplement, and it has worked excellently. Within a month, he noticed thinner blood, improved glucose levels, and normalised blood pressure. He is very happy with the results and highly recommends this product.

Brain Tumor

I trust this product as it truly works! I had a painful, swollen red lump on my inner thigh and felt a clot inside, which alarmed me due to the risk of it leading to serious conditions like a brain tumour. After discovering this product online, I am pleased to report that the clot vanished within a week, the swelling and pain subsided. I plan to continue using it for preventive health and appreciate the excellent price offered!

Diabetes

Nattokinase shows promise for DR

Protective effects of nattokinase against microvasculopathy and neuroinflammation in diabetic retinopathy.

Most Relevant Research

We aimed to explore the benefits of nattokinase (NK) in treating diabetic retinopathy (DR), a common and serious complication of diabetes that can lead to vision loss. Using a mouse model, we specifically induced diabetes through streptozotocin and treated the mice with NK via intravitreal injection, allowing us to closely observe its effects.

Our findings revealed some exciting results. NK significantly improved the function of the blood-retinal barrier, which is crucial for maintaining eye health. We also saw that NK helped to prevent the loss of important support cells in the retina known as pericytes.

Furthermore, the treatment reduced signs of neuroinflammation, which can cause further damage in diabetic eyes. This included a decrease in glial activation and a reduction in inflammation-related responses. Additionally, we also tested NK on human retinal cells in high glucose conditions, finding that it helped counteract dysfunction.

Importantly, our study suggests that NK works, at least in part, by affecting a specific inflammatory pathway linked to high mobility group box 1 (HMGB1) signaling in activated microglia. This work points toward NK as a promising potential treatment for early stages of diabetic retinopathy, paving the way for safer, cost-effective solutions in managing diabetes-related eye complications.

9.5

Saved leg from amputation

Most Useful Review

Saved Leg From Amputation - Along With Phototherapy. Years ago, I ran a therapy clinic focusing on electromagnetic therapies. I treated a patient with severe peripheral vascular disease who faced amputation. He had a dusky, purplish-red skin with severe tissue deprivation and 3+ pitting edema. I employed local phototherapy and liberal oral Nattokinase. Initially, his wife collected urine samples revealing oil-like material, which diminished over time. Nearly three years later, he had healthy, supple lower legs and strong pedal pulses, with no signs of Peripheral Vascular Disease. I have successfully saved four legs from amputation using this approach, including a 580lb diabetic patient whose second leg was saved. The wounds remained closed.

Hypertension

Nattokinase benefits high blood pressure

Possibly Effective

Based on 3 Researches

Nattokinase Supplementation and Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Most Relevant Research

We explored the effectiveness of nattokinase, a fibrinolytic enzyme derived from fermented soybeans, in managing hypertension. This study involved a systematic review of six randomized controlled trials, encompassing 546 participants. Through a robust methodology, including data extraction and risk assessment, we aimed to determine how nattokinase supplementation could support cardiovascular health.

Our findings indicated that nattokinase significantly reduced both systolic and diastolic blood pressure compared to a placebo. Specifically, we noted a decrease in systolic blood pressure by an average of 3.45 mm Hg and in diastolic blood pressure by 2.32 mm Hg. This suggests that nattokinase could be a beneficial adjunctive therapy for individuals struggling with high blood pressure.

However, it's important to highlight that while nattokinase may support blood pressure management, its effects on cholesterol levels were less encouraging. The study showed that lower doses of nattokinase could negatively impact total cholesterol and have no significant influence on triglyceride levels. Thus, while nattokinase appears promising for hypertension, the relationship between dosage and lipid levels warrants further investigation.

Overall, our research contributes to the understanding of nattokinase's role in hypertension treatment, highlighting its potential while pointing to areas that need more clarity regarding dosage and lipid interactions.

9.5

Improved blood pressure

Most Useful Review

I use nattokinase as an alternative to aspirin for thick blood to improve fluidity. High blood viscosity increases the risk of hypertension, myocardial infarction, and stroke. I take it in the evening after dinner and in the morning on an empty stomach with serrapeptase, and I have forgotten about my blood pressure issues!

Osteoporosis

High-quality supplement

Nattokinase, discovered in Japan, is a potent enzyme from natto known for improving blood fluidity and preventing osteoporosis, strokes, and heart diseases. The Japanese greatly value traditional soy products, leading to their longevity. This quality supplement is an excellent alternative to aspirin for maintaining healthy blood density.

Pneumonia

Memorable enhancement

I began using Doctors Best Nattokinase after a prolonged journey, leading to blood clots. A friend recommended it, and it relieved my pain and discoloration. Eight months later, I had pneumonia and was hospitalised. After a full-body scan, I had no clots! I’ve also noticed my memory has improved significantly.

Alzheimer

Alzheimer's assistance

This top cardiovascular supplement aids in blood flow and supports Alzheimer’s management effectively, avoiding the adverse effects of traditional medications like aspirin.

Breast Cancer

Cancer treatment benefits

Dr's Best Nattokinase is effective for clearing harmful proteins like cancer stem cells. It seems to be successfully helping me clear arteries and scar tissue, contributing favourably to my overall health regarding breast cancer.

Irritable Bowel Syndrome

After eating, I have no bowel movement issues, my stomach feels good, and my skin looks beautiful! Prior to the injection, I took two capsules a day without side effects, allowing me to return to work as usual. This is a remarkable product that can be taken without food!

Lung Cancer

Cardiovascular improvement

Nattokinase has significantly improved my cardiovascular health. After taking it, I felt more energetic and my blood viscosity seems to have decreased, potentially reducing the risk of lung cancer. This natural alternative to aspirin has no side effects, and I appreciate that it’s safe for long-term use.

Heartburn

Amazing results! My husband has always struggled with heartburn and other stomach issues. He noticed immediate improvement after taking this product, which has truly helped his gut health.

Indigestion

Immediate improvement

My husband has always faced stomach issues, including indigestion and heartburn. He noticed immediate improvement after starting this supplement, which significantly helped his microbiota because, after all, all health begins in the gut.

Neuropathy

I have used Dr's Best Nattokinase for several years. It's one of the few supplements where I can feel a difference from just one capsule. It helps my neuropathy and improves circulation in my cold legs and feet. I'm pleased to find a larger size available.

Reflux

Eliminated chronic stomach issues. Great product and solid brand. I have tried others successfully. Used it to correct 20 years of reflux and stomach ulcers. Can't be happier.

Ulcer

I am pleased to report that this product has eliminated my chronic stomach issues. I've used it as part of a regimen for 20 years of acid reflux and stomach ulcers. I couldn't be happier with the results; it's a solid brand that truly works for me.

Arteriosclerosis

Likely Ineffective