Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Nattokinase (from fibrinase enzymes)
2,000 FU**

The product is found useful for the following medical conditions

Cold details

SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 25 Reviews
8.7
We conducted a study to explore how a single dose of nattokinase (NK) influences recovery of skin temperature after exposure to cold water. This double-blind, placebo-controlled crossover study involved nine healthy men who took either NK or a placebo before submerging their hands in ice-cold water at 10 °C for one minute.

Our findings showed that participants who took NK experienced a quicker recovery of skin temperature in their middle finger, palm, and back of the hand compared to those who took the placebo. Although cold exposure initially caused a significant drop in skin temperature, the NK appeared to accelerate the warming process afterward.

Interestingly, we did not observe any changes in heart rate, cardiac output, or sympathetic nervous activity as a result of taking NK. This is noteworthy because it suggests that while NK may help with temperature recovery, it does not impact certain cardiovascular responses typically associated with cold exposure.

Overall, our study highlights the potential benefits of nattokinase, especially for individuals who are more sensitive to cold, such as women and the elderly. It could offer a new avenue for managing cold sensitivity and minimizing excessive vasoconstriction during chilly conditions.
10
Circulation improvement
Most Useful Review
48 people found this helpful
I bought this for my husband's cold left foot, which he couldn't feel for years. Within 24 hours of taking it, he regained feeling, and it felt warm again! He had thought he would suffer forever. Now, he’s active and claims he has his life back—his hands are warm too. He takes one capsule in the morning and another before dinner. We ordered multiple bottles to keep this up. We're incredibly grateful for this product!

Brain Tumor details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Clot disappearance
Most Useful Review
12 people found this helpful
I trust this product as it truly works! I had a painful, swollen red lump on my inner thigh and felt a clot inside, which alarmed me due to the risk of it leading to serious conditions like a brain tumour. After discovering this product online, I am pleased to report that the clot vanished within a week, the swelling and pain subsided. I plan to continue using it for preventive health and appreciate the excellent price offered!

Cancer details

SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.8
USERS' SCORE
Good
Based on 14 Reviews
8.6
We assessed the impact of nattokinase crude extract (NCE) on liver cancer, specifically hepatocellular carcinoma (HCC), using mouse models.

Mice receiving NCE exhibited a 31% survival rate improvement and reduced tumor sizes, as indicated by imaging and pathology evaluations.

Additionally, NCE led to decreased levels of several cancer markers.

Overall, these findings suggest that nattokinase may positively influence liver cancer outcomes in this model.
9
Blood thickness improvement
Most Useful Review
608 people found this helpful
It's working! My husband has a rare blood cancer (polycythemia vera) that makes his blood too thick. He was having a pint of blood taken every two weeks. I researched options and started him on several supplements. After six weeks, the doctor hasn't had to draw any blood. We'll continue this treatment.

Angina details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 8 Reviews
8.5
9
No more angina
Most Useful Review
9 people found this helpful
Nattokinase has changed my life. For years, I took daily aspirin but still experienced angina when working. After starting nattokinase for another issue, I could work double the time without any angina the very next day. It has replaced aspirin and has been beneficial for the last four years without any side effects.

Asthma details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.5
9
Prevents asthma attacks.
Most Useful Review
I take it on an empty stomach consistently, along with serrapeptase and quercetin. It significantly helps with asthma, as I have no attacks now.

Menopause details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.5
9
Significant pain reduction
Most Useful Review
Menopause comes with many symptoms, but after taking this nattokinase, my pain has greatly improved. Keep up the good work.

Atrial Fibrillation details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.4
9
Discontinued anticoagulants
Most Useful Review
4 people found this helpful
I have been using nattokinase for about two years now and, as I have Atrial Fibrillation, it has permitted me to stop taking the anticoagulant I was on.

Common Cold details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 10 Reviews
8.4
9
No more cold feet
Most Useful Review
2 people found this helpful
I've struggled with poor circulation and cold feet, even in warm weather. After switching from Norvasc to this product, I no longer have cold feet. It may also be helping my backache.

Dizziness details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 18 Reviews
8.4
9
Dizziness improvement
Most Useful Review
41 people found this helpful
I ordered it for my husband alongside a neuro optimizer. He constantly experienced dizziness and a heavy feeling in the back of his head. After a week of taking these drugs, the dizziness and heaviness disappeared, along with improved clarity and mood. He takes the drug as directed and is very pleased! Thank you, iHerb!

Endometriosis details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.4
9
Restored fertility
Most Useful Review
8 people found this helpful
Unblocked My Fallopian Tubes. Both of my tubes were blocked due to endometriosis. After taking this for a month, I had an HSG test and found both tubes unblocked! My period also shortened from 8-10 days to 6-7 days with no more heavy bleeding or adhesions. Definitely worth it!

Hemorrhoids details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 17 Reviews
8.4
9
Disappeared in days
Most Useful Review
51 people found this helpful
Natokinaz is fantastic! My hemorrhoids, which had persisted for many months, vanished in just 10 days. It's a brilliant supplement. Forget about Detraleks, Venarus and the likes. I will be ordering it for my parents to help with blood circulation. For women experiencing abdominal pain and headaches during menstruation, I highly recommend taking this supplement 10 days prior; the results are remarkable.

Migraine details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 14 Reviews
8.4
9
Remarkable recovery
Most Useful Review
47 people found this helpful
Works well. After struggling with clots and a permanent migraine for three months, taking three natto daily for just a few days eliminated my seemingly permanent migraine. I couldn't believe the difference.

Prostate Cancer details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.4
7.5
Weight loss success
Most Useful Review
2 people found this helpful
Kari L. Soderberg Very good product. It's the only place we found Nattokinase in 2000 FUs, and the price was excellent. My husband took this product to lower his PSA count, and so far, so good! With diet, exercise, and daily Nattokinase, he has lost 35 pounds. He is committed to taking supplements, eating sensibly, and exercising to combat prostate cancer before it manifests.

Sinusitis details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 6 Reviews
8.4
10
Effective against sinusitis
Most Useful Review
1 people found this helpful
My brother combined nattokinase with serrapeptase and effectively resolved his sinusitis. It's truly remarkable how well this approach worked for him!

Ulcer details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 7 Reviews
8.4
9
Corrects past issues
Most Useful Review
22 people found this helpful
I am pleased to report that this product has eliminated my chronic stomach issues. I've used it as part of a regimen for 20 years of acid reflux and stomach ulcers. I couldn't be happier with the results; it's a solid brand that truly works for me.

Neuropathy details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.4
8
Enhances circulation
Most Useful Review
14 people found this helpful
I have used Dr's Best Nattokinase for several years. It's one of the few supplements where I can feel a difference from just one capsule. It helps my neuropathy and improves circulation in my cold legs and feet. I'm pleased to find a larger size available.

Acanthosis Nigricans details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.3
7.5
Improved condition
Most Useful Review
3 people found this helpful
Great supplement! I took it on an empty stomach an hour before meals with aitis and serrapeptase. The benefits of systemic enzymes are significant; my thyroid gland reduced in size and many nodules disappeared, resulting in a much improved condition. Additionally, I took tyrosine and selenium.

Allergies details

SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 20 Reviews
8.3
We examined the effects of nattokinase, a protease found in natto, on allergies. Our study involved eight individuals who experienced allergic reactions after consuming natto, specifically the sticky substance surrounding the beans. Some participants tested negative for polygamma glutamic acid (PGA), which was previously identified as a potential allergen.

Throughout our investigation, we employed skin prick tests, immunoblotting, and ELISA to assess the reactivity to nattokinase and other components. Notably, we discovered that a subset of patients, particularly those who were negative for PGA, exhibited an allergic response to nattokinase. This finding suggests that nattokinase may act as a distinct allergen in certain individuals.

In the end, we identified nattokinase as a new allergen linked to natto allergy, particularly in those not sensitized to PGA. While our study highlights the allergenic potential of nattokinase, its broader implications for allergy treatment remain to be fully explored.
7.5
Sinuses opened
Most Useful Review
17 people found this helpful
Shockingly, this is opening my sinuses! I've ordered a second bottle. Spring/Summer allergies here in Las Vegas are challenging, but this product seems to open my sinuses and helps me breathe better.

Arteriosclerosis details

SCIENTIFIC SCORE
Likely Ineffective
Based on 2 Researches
4.5
USERS' SCORE
Good
Based on 8 Reviews
8.3
We conducted a comprehensive study to investigate the effect of nattokinase on the progression of atherosclerosis, a condition that can lead to serious cardiovascular diseases. In this double-blind trial, we involved 265 participants with a median age of 65.3 years, all of whom did not show signs of existing cardiovascular disease. They were randomly assigned to receive either nattokinase or a placebo.

Over the course of a median of three years, we closely monitored changes in subclinical atherosclerosis using techniques such as carotid ultrasound. This allowed us to measure vital indicators like carotid artery intima-media thickness (CIMT) and arterial stiffness. We also tracked other health metrics, including blood pressure and various laboratory factors related to metabolism and inflammation.

Ultimately, our findings revealed that nattokinase supplementation did not significantly alter the rate of atherosclerosis progression compared to the placebo group. We also noted no meaningful changes in blood pressure or any other assessed laboratory measures. Thus, it's clear that nattokinase does not provide notable cardiovascular benefits in terms of slowing down the development of atherosclerosis for individuals at low risk of cardiovascular disease.
9
Improves health effectively
Most Useful Review
3 people found this helpful
Doctors Best Nattokinase, 2,000FU is excellent! I discovered that natto supplements are beneficial for improving arteriosclerosis and maintaining good health, particularly since my blood pressure is high. I found iHerb, where I purchased a large quantity of 270 capsules at a reasonable price nearly a year ago. I've consistently bought in bulk, impressed by the quality and affordability. I owe my gratitude to iHerb for enhancing arterial health and sustaining my wellbeing. This supplement is essential for the elderly, and I plan to continue its use, hoping it remains available at a good price. I appreciate their prompt service.

Bacterial Infection details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 10 Reviews
8.3
9
Improves infection
Most Useful Review
11 people found this helpful
A wonderful tool that has helped with a chronic bacterial infection, improving blood supply and offered at a good price.

Chest Pain details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 29 Reviews
8.3
9
Clot dissolution success
Most Useful Review
43 people found this helpful
Nattokinase dissolved my leg clots in just 11 days. Initially sceptical due to my doctor’s warnings about alternative treatments, I experienced a severe allergic reaction to Lovenox shots. Once I started Nattokinase, my clots vanished, and my blood pressure significantly improved. I take it on an empty stomach and truly believe it worked for me.

Flu details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 17 Reviews
8.3
9
Reliable for immune health
Most Useful Review
1 people found this helpful
We have been using this for years. This Nattokinase is reliable, clearly benefiting our immune health and detoxing from the "spicy flu". It truly works.

Indigestion details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.3
9
Immediate improvement
Most Useful Review
13 people found this helpful
My husband has always faced stomach issues, including indigestion and heartburn. He noticed immediate improvement after starting this supplement, which significantly helped his microbiota because, after all, all health begins in the gut.

Leg Cramps details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 53 Reviews
8.3
9
Pain relief
Most Useful Review
142 people found this helpful
I'm currently taking nattokinase. After the coronavirus, my legs became painful and swollen in the evenings, which I hadn't experienced before. Small veins appeared on my legs. Having taken it for over a month, the pain and swelling have disappeared. It's a shame I didn't discover this product earlier. I recommend it for improving blood flow!

Lung Cancer details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 8 Reviews
8.3
9
Cardiovascular improvement
Most Useful Review
47 people found this helpful
Nattokinase has significantly improved my cardiovascular health. After taking it, I felt more energetic and my blood viscosity seems to have decreased, potentially reducing the risk of lung cancer. This natural alternative to aspirin has no side effects, and I appreciate that it’s safe for long-term use.

Pneumonia details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 6 Reviews
8.3
9
Memorable enhancement
Most Useful Review
13 people found this helpful
I began using Doctors Best Nattokinase after a prolonged journey, leading to blood clots. A friend recommended it, and it relieved my pain and discoloration. Eight months later, I had pneumonia and was hospitalised. After a full-body scan, I had no clots! I’ve also noticed my memory has improved significantly.

Swollen Lymph Nodes details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 42 Reviews
8.3
9
Leg pain relief
Most Useful Review
142 people found this helpful
I’m currently taking nattokinase. Following a coronavirus infection, my legs began to hurt and swell in the evenings, despite not having had such issues previously. After more than a month of this product, the pain and swelling in my legs disappeared. I wish I had discovered this product sooner! It’s great for improving circulation!

Uterine Fibroids details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.3
9
Size reduction noted
Most Useful Review
4 people found this helpful
The Nattokinase from this company works effectively. The quality is excellent, and the dosage is adequate to feel the impact. I took it to reduce fibroids along with Serrapeptase. Remarkably, my Uterine Fibroids stopped growing and even decreased over two weeks. This is a fantastic result and also beneficial for blood thinning. Highly recommended!

Adenoiditis details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.2
9
Sore throat relief
Most Useful Review
1 people found this helpful
I've been taking this product for about 15 days and feel excellent. After suffering from a sore throat, that symptom has subsided. I recommend it to others.

Atrial Flutter details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.2
7.5
Significantly improved health
Most Useful Review
235 people found this helpful
A unique enzyme necessary for preventing a significant number of diseases, it contributes greatly to the normal functioning of the heart. It reduces the risk of most cardiovascular diseases by dissolving excess fibrin in blood vessels, improving circulation, dissolving blood clots, and lowering LDL cholesterol while increasing HDL cholesterol. My Covid saviour! Although I struggled to breathe despite good saturation and no wheezing, I began to experience arrhythmia, insomnia, and visible veins. Realising the ineffectiveness of doctors, I started taking nattokinase. I felt the impact of every pill, initially taking three daily and reducing as I improved. I also included serrapeptase and arjuna in my regimen.

Autoimmune Disorder details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 31 Reviews
8.2
9
Blood thinner effective
Most Useful Review
86 people found this helpful
Great natural blood thinner. My father struggled with thick blood due to cholesterol and an autoimmune disorder. He developed diabetes after Covid, worsening his condition. After trying various blood thinners, I ordered him this well-rated Nattokinase supplement, and it has worked excellently. Within a month, he noticed thinner blood, improved glucose levels, and normalised blood pressure. He is very happy with the results and highly recommends this product.

Back Pain details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 40 Reviews
8.2
9
Eliminated back pain
Most Useful Review
27 people found this helpful
It works wonders! After taking two capsules morning and night for two weeks, the persistent pain on the left side of my neck disappeared. My mum also noticed relief from her varicose veins.

Blood Clot details

SCIENTIFIC SCORE
Moderately Effective
Based on 18 Researches
8.4
USERS' SCORE
Good
Based on 281 Reviews
8.2
We explored the effectiveness of nattokinase, a natural enzyme known for its role in breaking down blood clots, by studying its production and activity in a lab setting. Nattokinase was extracted from Bacillus subtilis, and we introduced this gene into E. coli bacteria to produce the enzyme at high levels.

Through our process, we purified the active recombinant nattokinase and tested its ability to dissolve blood clots. Our results were promising; the enzyme exhibited a fibrinolytic activity of 58FU/mg, which is notably five times more effective than the currently used drug, orokinase.

We optimized the conditions for producing nattokinase, including factors like temperature and nutrient concentrations, resulting in an impressive yield of 1805.50 mg/L. This improved production method paves the way for scaling up nattokinase's use in treating cardiovascular diseases related to blood clots. The findings emphasize nattokinase's potential as an effective thrombolytic agent.
9
Improved blood circulation
Most Useful Review
895 people found this helpful
I take nattokinase for blood thinning. Blood tests showed aggregation of erythrocytes and platelets, but after a month of use, there was significant improvement. I experienced heaviness in my head and legs, which gradually subsided. All tests returned to normal.

Blurred Vision details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 14 Reviews
8.2
9
Effective for sciatica
Most Useful Review
7 people found this helpful
After suffering from sciatica, I turned to Nattokinase following acupuncture recommendations. After nearly two weeks of taking two capsules daily, my sciatica and calf pain have improved by about 90%. The effectiveness is remarkable. Most importantly, my blurred vision has cleared up considerably.

Candidiasis details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 14 Reviews
8.2
8
Improved well-being
Most Useful Review
1 people found this helpful
This product is effective and genuinely thins the blood. Both my mother and I noticed improvement; it integrates well with other medications for candidiasis. An excellent remedy that truly works!

Cardiovascular Disease details

SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.1
USERS' SCORE
Good
Based on 205 Reviews
8.2
We examined how nattokinase affects the progression of atherosclerosis and related biomarkers in a double-blind trial involving 265 participants averaging 65 years old, who had no cardiovascular disease. Participants received either nattokinase or a placebo for three years.

Our findings revealed that nattokinase had no significant effect on subclinical atherosclerosis progression, blood pressure, or other laboratory measures. This indicates that nattokinase may not provide the anticipated cardiovascular benefits in healthy individuals at low risk for heart disease.
9
Relieved arrhythmia symptoms
Most Useful Review
235 people found this helpful
Nattokinase is a unique enzyme essential for preventing various diseases, significantly aiding heart function. It improves blood circulation, dissolves blood clots, reduces the risk of cardiovascular disease, and promotes healthy cholesterol levels. After experiencing severe symptoms, I took nattokinase and felt improvements with each pill, eventually reducing my dosage as I felt better.

Cholecystitis details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.2
9
Restored Wellbeing
Most Useful Review
I order Nattokinase for my mother to aid blood thinning, and her health has improved significantly. After four months of use, her tests are good, and she feels energetic at 69. We use only dietary supplements instead of pharmacy drugs.

Cold Sores details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 13 Reviews
8.2
9
Restored feeling back
Most Useful Review
48 people found this helpful
I bought this for my husband's cold and nearly numb left foot. Within 24 hours, he felt improvement; within 48 hours, his foot felt normal again. His feet, always cold even in summer, are now warm. He is no longer stumbling around and genuinely feels he’s regained his life. He takes one capsule in the morning and another before dinner.

Diabetes details

SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.5
USERS' SCORE
Good
Based on 12 Reviews
8.2
We aimed to explore the benefits of nattokinase (NK) in treating diabetic retinopathy (DR), a common and serious complication of diabetes that can lead to vision loss. Using a mouse model, we specifically induced diabetes through streptozotocin and treated the mice with NK via intravitreal injection, allowing us to closely observe its effects.

Our findings revealed some exciting results. NK significantly improved the function of the blood-retinal barrier, which is crucial for maintaining eye health. We also saw that NK helped to prevent the loss of important support cells in the retina known as pericytes.

Furthermore, the treatment reduced signs of neuroinflammation, which can cause further damage in diabetic eyes. This included a decrease in glial activation and a reduction in inflammation-related responses. Additionally, we also tested NK on human retinal cells in high glucose conditions, finding that it helped counteract dysfunction.

Importantly, our study suggests that NK works, at least in part, by affecting a specific inflammatory pathway linked to high mobility group box 1 (HMGB1) signaling in activated microglia. This work points toward NK as a promising potential treatment for early stages of diabetic retinopathy, paving the way for safer, cost-effective solutions in managing diabetes-related eye complications.
9
Saved leg from amputation
Most Useful Review
290 people found this helpful
Saved Leg From Amputation - Along With Phototherapy. Years ago, I ran a therapy clinic focusing on electromagnetic therapies. I treated a patient with severe peripheral vascular disease who faced amputation. He had a dusky, purplish-red skin with severe tissue deprivation and 3+ pitting edema. I employed local phototherapy and liberal oral Nattokinase. Initially, his wife collected urine samples revealing oil-like material, which diminished over time. Nearly three years later, he had healthy, supple lower legs and strong pedal pulses, with no signs of Peripheral Vascular Disease. I have successfully saved four legs from amputation using this approach, including a 580lb diabetic patient whose second leg was saved. The wounds remained closed.

Heart Disease details

SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 216 Reviews
8.2
We explored the potential of a novel treatment using nattokinase combined with manganese oxide nanozymes to tackle acute myocardial infarction caused by blood clots. This innovative approach aims to enhance thrombolytic therapy and combat oxidative stress. The study found that injecting this nattokinase-loaded nanozyme significantly restored blood flow and reduced heart damage in mouse models of heart attacks. While the results are promising, suggesting a new avenue for treatment, further research is necessary to establish its effectiveness in humans.
9
Prevented heart problems
Most Useful Review
293 people found this helpful
I learned about nattokinase after my father's heart attack. Since switching him to this natural supplement, he has not faced any further issues. His blood circulation has improved significantly, making this an essential supplement for those with heart disease.

Knee Pain details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 22 Reviews
8.2
9
Effective for arthritis
Most Useful Review
34 people found this helpful
Best supplement for joint pain! I've taken Nattokinase, Serrapeptase, and Bromelain three times daily away from food, and they’ve become essential in managing my rheumatoid arthritis. My knee pain diminished after a couple of weeks of use. Highly recommend!

Rheumatoid Arthritis details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 7 Reviews
8.2
9
Pain relief
Most Useful Review
34 people found this helpful
I’m taking nattokinase along with serrapeptase and bromelain three times a day away from food, and they have become my best allies in managing rheumatoid arthritis. The quality, size, and dosage of these products are excellent. After a few weeks of use, my pain vanished. I wholeheartedly recommend them; you will soon notice the benefits and reclaim your normal life.

Weight Loss details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.2
7.5
Supports weight loss
Most Useful Review
94 people found this helpful
Nattokinase is a crucial enzyme that enhances healthy blood flow. Its multifaceted properties include normalising blood circulation. Studies have shown its high fibrinolytic activity, heart and vessel health benefits, bone strengthening, vision protection, detoxification support, oxygen transport to peripheral areas, cholesterol accumulation reduction, and metabolic activation, which aids in weight loss. It effectively addresses varicose veins by dissolving blood clots and manages elevated cholesterol, inhibiting atherosclerosis development. This enzyme also promotes tissue oxygen saturation and alleviates vascular spasms. I trust it for my health.

Breast Cancer details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.1
9
Cancer treatment benefits
Most Useful Review
1 people found this helpful
Dr's Best Nattokinase is effective for clearing harmful proteins like cancer stem cells. It seems to be successfully helping me clear arteries and scar tissue, contributing favourably to my overall health regarding breast cancer.

Chronic Cough details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.1
7.5
Reduced coughing
Most Useful Review
After my diagnosis, I sometimes had a scratchy throat and chronic cough. Since taking nattokinase, my symptoms have improved significantly.

Chronic Fatigue Syndrome details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 26 Reviews
8.1
9
Fast pressure relief
Most Useful Review
27 people found this helpful
Nattokinase was incredibly helpful for my chronic fatigue syndrome and hypotension, quickly raising my blood pressure and reducing the noise in my head.

Ear Infection details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 9 Reviews
8.1
7.5
Reduced ear discomfort
Most Useful Review
4 people found this helpful
Initially, I faced issues with blood vessels, including pain in my left foot and convulsions. After trying Nattokinase, I'm pleased with the outcome; the pain has subsided, and my heart rate normalised. This previously caused me to struggle sleeping as I heard my pulse pounding in my ear. Seizures have become less frequent. I'm eager to order more.

Heart Attack details

SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.8
USERS' SCORE
Good
Based on 88 Reviews
8.1
We aimed to explore the effectiveness of nattokinase, an enzyme with potent fibrinolytic properties, in treating heart attacks. Through our research, we focused on enhancing the production of nattokinase from a newly identified strain of Pseudomonas aeruginosa, referred to as CMSS, which we isolated from cow milk.

Our comprehensive study involved optimizing different growth conditions such as pH, temperature, and nutrient sources, alongside improving the strain through UV-mutagenesis. We were excited to find that these optimizations led to a significant increase in nattokinase production.

The standout results showed that our modified strain produced nattokinase with a maximum activity of 4263 U mL(-1), which is double that of the original strain. In practical terms, this nattokinase achieved an impressive 94% blood clot lysis within ten minutes, hinting at its potential as a rapid acting treatment for heart-related issues.

Overall, our findings suggest that nattokinase from Pseudomonas aeruginosa CMSS could be a promising candidate for thrombolytic therapy, notably for those at risk of acute myocardial infarction. This unique study represents the first report of nattokinase production from this microorganism, opening the door to further research.
9
No further heart attacks
Most Useful Review
293 people found this helpful
I learned about nattokinase after my father was diagnosed with heart problems, having suffered a heart attack. We consulted his physician and switched to natural treatment with nattokinase. After a year, his blood circulation improved, and he hasn't had any further heart attacks. This truly is essential for heart patients.

High Cholesterol details

SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 159 Reviews
8.1
This study examined whether nattokinase monascus supplements could effectively lower cholesterol levels in people facing dyslipidemia. In a randomized trial with 113 participants, we noted significant reductions in total cholesterol, LDL cholesterol, and similar lipid markers after 120 days of using the supplements compared to a placebo.

However, we didn't see any notable improvements in triglycerides, HDL cholesterol, or carotid intima-media thickness. Importantly, participants experienced no major side effects from the treatment. Overall, while nattokinase supplements showed promise for some cholesterol levels, they did not deliver significant changes in all examined lipid factors.
9
Thinned blood
Most Useful Review
394 people found this helpful
My father has had thick blood due to high cholesterol and blood clots for years. After developing diabetes post-Covid, he faced more challenges. I ordered this highly rated Nattokinase supplement for him, and within a month, he noticed his blood becoming much thinner. His blood pressure is also normalising after a long struggle with it. He is extremely pleased with the results and highly recommends this product.

Rash details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.1
7.5
Reduced rashes
Most Useful Review
1 people found this helpful
I purchased nattokinase and serrapeptase from Dr Best to use together for heart health. I take a high dose of 4 capsules of each (serrapeptase 120,000 SPU per capsule). After 2 weeks, I have noticed fewer rashes, better circulation (my very pale skin looks improved), and some leg injuries are healing.

Stroke details

SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.5
USERS' SCORE
Good
Based on 54 Reviews
8.1
We explored how nattokinase, a serine protease derived from the traditional food natto, can benefit individuals who have experienced strokes, particularly focusing on cognitive recovery. Our study specifically aimed to uncover whether nattokinase can act as an anti-post-stroke cognitive impairment (PSCI) agent by influencing blood factors that are crucial for brain health.

The results were telling. We discovered that nattokinase has protective effects against acute ischemic strokes and plays a significant role in promoting neurogenesis, which is the process of generating new brain cells. Through experiments conducted on rat models, we observed that nattokinase notably increases irisin levels in peripheral blood. Irisin is a protein that has emerged as an interesting player in enhancing cognitive functions.

By linking the increased levels of irisin to improved cognitive abilities, our findings suggest that nattokinase could be a promising therapy for those suffering from PSCI, positioning irisin as a potential target for treatment. Overall, our research highlights the exciting possibilities that nattokinase offers in the realm of stroke recovery and brain health.
9
Hydrates blood effectively
Most Useful Review
188 people found this helpful
I use nattokinase instead of aspirin for thick blood, enhancing its fluidity. High blood viscosity poses a risk for strokes, hence I take it in the evening and on an empty stomach in the morning. It helps me forget my blood pressure issues!

Cough details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8
9
No cough annoyance
Most Useful Review
I take a couple of these in the morning on an empty stomach, alongside serrapeptase. The effects are noticeable; no headaches even with weather changes in autumn, my skin is clearer, and the cough does not bother me at all. No side effects. Highly recommend 👍👍👍

Headache details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 68 Reviews
8
9
Healed headaches
Most Useful Review
51 people found this helpful
Nattokinase is remarkable. It cured my hemorrhoids in ten days. This supplement surpasses others such as Detralex and Venarus. I recommend it to women suffering from menstrual pain and headaches; they’ll notice the difference when they start taking it 10 days before their period.

Hypertension details

SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.8
USERS' SCORE
Good
Based on 36 Reviews
8
We evaluated how nattokinase affects blood pressure in people living with pre-hypertension or stage 1 hypertension. In this randomized, double-blind, placebo-controlled trial involving 86 participants, we found that those taking nattokinase showed a significant drop in both systolic and diastolic blood pressure after 8 weeks. Specifically, systolic blood pressure decreased by an average of 5.55 mmHg, while diastolic blood pressure fell by 2.84 mmHg. Our results suggest that nattokinase could be a beneficial option in managing hypertension.
9
Improved blood pressure
Most Useful Review
188 people found this helpful
I use nattokinase as an alternative to aspirin for thick blood to improve fluidity. High blood viscosity increases the risk of hypertension, myocardial infarction, and stroke. I take it in the evening after dinner and in the morning on an empty stomach with serrapeptase, and I have forgotten about my blood pressure issues!

Liver Disease details

SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.8
USERS' SCORE
Good
Based on 43 Reviews
8
We assessed the effects of nattokinase crude extract (NCE) on hepatocellular carcinoma (HCC) growth in mouse models. Our findings revealed that NCE significantly improved survival rates among treated mice and resulted in decreased tumor size. The extract lowered levels of specific proteins associated with cancer progression, further indicating its potential as a treatment option. Overall, we found that NCE leads to both enhanced survival and reduced tumor growth in HCC-bearing mice.
9
No more pain
Most Useful Review
138 people found this helpful
Welcomed Relief! I'm a very active 62-year-old male in good health and physical condition. However, I recently suffered severe "burning" pain in the calf muscles of both legs. My doctor informed me that I had developed P.A.D.s (peripheral vascular disease). Though I always walked 3-5 miles daily, the condition made it extremely painful. The doctor advised me to keep walking, hoping the pain would subside. A relative suggested I try Doctors Best, Best Nattokinase. After taking one capsule in the morning and another in the evening, I went for a 4-mile walk the next day and experienced "No more burning pain"! I continue to take two capsules daily.

Sleep Apnea details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 6 Reviews
8
9
Resolved nasal issues
Most Useful Review
1 people found this helpful
Since switching to nattokinase for my severe nasal congestion caused by sleep apnea, I’ve noticed a remarkable improvement in my ability to breathe freely during the night.

Bone Pain details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 55 Reviews
7.9
9
Leg pain reduction
Most Useful Review
142 people found this helpful
I've been using nattokinase for over a month now since my legs started swelling and aching after the coronavirus. Thankfully, the pain and swelling have disappeared. I wish I had known about this sooner; it has significantly improved my leg discomfort and blood circulation. I recommend it for better blood flow!

Irritable Bowel Syndrome details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 17 Reviews
7.9
9
Healthy digestion
Most Useful Review
7 people found this helpful
After eating, I have no bowel movement issues, my stomach feels good, and my skin looks beautiful! Prior to the injection, I took two capsules a day without side effects, allowing me to return to work as usual. This is a remarkable product that can be taken without food!

Osteoporosis details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 20 Reviews
7.9
9
High-quality supplement
Most Useful Review
1 people found this helpful
Nattokinase, discovered in Japan, is a potent enzyme from natto known for improving blood fluidity and preventing osteoporosis, strokes, and heart diseases. The Japanese greatly value traditional soy products, leading to their longevity. This quality supplement is an excellent alternative to aspirin for maintaining healthy blood density.

Abscess details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.8
7.5
Improves circulation
Most Useful Review
2 people found this helpful
I take nattokinase and serrapeptase on an empty stomach. These enzymes help reduce unwanted protein, cysts, and mucus. Nattokinase specifically targets blood clots, enhances circulation, and helps remove cholesterol. It also stimulates oxygen delivery to cells, potentially benefiting overall health.

Alzheimer details

SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8
USERS' SCORE
Moderately Good
Based on 13 Reviews
7.8
We explored how chronic Nattokinase (NK) treatment influences neuropsychiatric complications tied to Alzheimer's disease in mice. By administering NK to mice injected with β-amyloid peptide, we observed reduced signs of depression, anxiety, and memory impairments—key indicators of Alzheimer’s progression. NK treatment led to improvements in cognitive performance and normalized chemical changes in the brain, similar to the effects of donepezil, a known Alzheimer’s medication. This suggests that Nattokinase could be a promising avenue for addressing behavioral and cognitive challenges in Alzheimer’s.
9
Alzheimer's assistance
Most Useful Review
This top cardiovascular supplement aids in blood flow and supports Alzheimer’s management effectively, avoiding the adverse effects of traditional medications like aspirin.

Gastritis details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.8
7.5
Suitable option
Most Useful Review
2 people found this helpful
I regularly purchase nattokinase, recognising the importance of thinning my blood at my age. It suits me perfectly as it does not negatively impact my chronic gastritis.

Constipation details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 5 Reviews
7.7
9
Improved toilet frequency
Most Useful Review
It aids in alleviating constipation and activates my sluggish stomach. I find myself rushing to the loo daily, which reflects its effectiveness. Drinking plenty of water is essential. The quality is high, and the pills are an average size, convenient to swallow.

Arthritis details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 10 Reviews
7.6
9
Pain reduction achieved
Most Useful Review
34 people found this helpful
I'm taking nattokinase alongside Serrapeptase and Bromelain three times a day away from food; these have become my best allies in battling rheumatoid arthritis. The quality, size, and dosage of these products are excellent. After a few weeks, my pain subsided, and I wholeheartedly recommend them. You'll soon notice the benefits and return to a normal life.

Mild Cognitive Impairment details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.2
9
Prevents heart attacks
Most Useful Review
6 people found this helpful
Nattokinase is a natural fermented blood thinner that helps prevent blood clots, thus reducing the risk of heart attacks and strokes. It is much safer and more effective than aspirin and is noted for aiding conditions such as varicose veins. Additionally, it alleviates muscle and leg pains, swelling, and numbness. It is recommended for older individuals, as many Japanese patients with senile dementia link their condition to cerebral thrombosis.

Tinnitus details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Medium or Average
Based on 3 Reviews
6.9
7.5
Improved blood supply
Most Useful Review
After Covid, I experienced issues with my blood vessels and began taking Nattokinase daily on an empty stomach. Within 10 days, I noticed visual improvements in my veins. Three weeks in, the blood supply to my limbs improved, and their chilliness reduced. Furthermore, my tinnitus has significantly decreased.
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