Last update
4/5/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 20 Reviews
8.3
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Nattokinase (from fibrinase enzymes)
2,000 FU**
†
Top Medical Research Studies
7
We examined the effects of nattokinase, a protease found in natto, on allergies. Our study involved eight individuals who experienced allergic reactions after consuming natto, specifically the sticky substance surrounding the beans. Some participants tested negative for polygamma glutamic acid (PGA), which was previously identified as a potential allergen.
Throughout our investigation, we employed skin prick tests, immunoblotting, and ELISA to assess the reactivity to nattokinase and other components. Notably, we discovered that a subset of patients, particularly those who were negative for PGA, exhibited an allergic response to nattokinase. This finding suggests that nattokinase may act as a distinct allergen in certain individuals.
In the end, we identified nattokinase as a new allergen linked to natto allergy, particularly in those not sensitized to PGA. While our study highlights the allergenic potential of nattokinase, its broader implications for allergy treatment remain to be fully explored.
Throughout our investigation, we employed skin prick tests, immunoblotting, and ELISA to assess the reactivity to nattokinase and other components. Notably, we discovered that a subset of patients, particularly those who were negative for PGA, exhibited an allergic response to nattokinase. This finding suggests that nattokinase may act as a distinct allergen in certain individuals.
In the end, we identified nattokinase as a new allergen linked to natto allergy, particularly in those not sensitized to PGA. While our study highlights the allergenic potential of nattokinase, its broader implications for allergy treatment remain to be fully explored.
Read More
Most Useful Reviews
7.5
Sinuses opened
17 people found this helpful
Shockingly, this is opening my sinuses! I've ordered a second bottle. Spring/Summer allergies here in Las Vegas are challenging, but this product seems to open my sinuses and helps me breathe better.
Read More
9
Better breathing
16 people found this helpful
Very pleased with this in our regime. We take it with Serrapeptase and MK7 on an empty stomach in the morning and evening. While we hope it helps unclog our arteries, it has certainly improved our breathing, eliminating congestion, reducing snoring, and easing seasonal allergies this year. We have taken these three items for four months and are sold on them.
Read More
7.5
Breathing improvement
12 people found this helpful
I bought serrapeptase and nattokinase from this company. After taking one enzyme in the morning and another in the evening, I noticed a significant improvement in my nasal breathing. I have always suffered from allergies, possibly due to food. When I stopped using these enzymes, the effect lasted about a week.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
- All Researches
7
We examined the effects of nattokinase, a protease found in natto, on allergies. Our study involved eight individuals who experienced allergic reactions after consuming natto, specifically the sticky substance surrounding the beans. Some participants tested negative for polygamma glutamic acid (PGA), which was previously identified as a potential allergen.
Throughout our investigation, we employed skin prick tests, immunoblotting, and ELISA to assess the reactivity to nattokinase and other components. Notably, we discovered that a subset of patients, particularly those who were negative for PGA, exhibited an allergic response to nattokinase. This finding suggests that nattokinase may act as a distinct allergen in certain individuals.
In the end, we identified nattokinase as a new allergen linked to natto allergy, particularly in those not sensitized to PGA. While our study highlights the allergenic potential of nattokinase, its broader implications for allergy treatment remain to be fully explored.
Throughout our investigation, we employed skin prick tests, immunoblotting, and ELISA to assess the reactivity to nattokinase and other components. Notably, we discovered that a subset of patients, particularly those who were negative for PGA, exhibited an allergic response to nattokinase. This finding suggests that nattokinase may act as a distinct allergen in certain individuals.
In the end, we identified nattokinase as a new allergen linked to natto allergy, particularly in those not sensitized to PGA. While our study highlights the allergenic potential of nattokinase, its broader implications for allergy treatment remain to be fully explored.
Read More
User Reviews
USERS' SCORE
Good
Based on 20 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Sinuses opened
17 people found this helpful
Shockingly, this is opening my sinuses! I've ordered a second bottle. Spring/Summer allergies here in Las Vegas are challenging, but this product seems to open my sinuses and helps me breathe better.
Read More
9
Better breathing
16 people found this helpful
Very pleased with this in our regime. We take it with Serrapeptase and MK7 on an empty stomach in the morning and evening. While we hope it helps unclog our arteries, it has certainly improved our breathing, eliminating congestion, reducing snoring, and easing seasonal allergies this year. We have taken these three items for four months and are sold on them.
Read More
7.5
Breathing improvement
12 people found this helpful
I bought serrapeptase and nattokinase from this company. After taking one enzyme in the morning and another in the evening, I noticed a significant improvement in my nasal breathing. I have always suffered from allergies, possibly due to food. When I stopped using these enzymes, the effect lasted about a week.
Read More
9
Supports allergy relief
3 people found this helpful
I've been taking Nattokinase for my respiratory allergies, following the advice that it aids sinus issues. Taking it after dinner has improved my digestion and allergies. I appreciate the quality and ingredients. I take it with water to avoid the taste, and it works well for me.
Read More
9
Effective for allergies
2 people found this helpful
I had an allergy of unknown cause, but after trying this product, I found it effective.
Read More
Frequently Asked Questions
7.5
Breathing improvement
12 people found this helpful
I bought serrapeptase and nattokinase from this company. After taking one enzyme in the morning and another in the evening, I noticed a significant improvement in my nasal breathing. I have always suffered from allergies, possibly due to food. When I stopped using these enzymes, the effect lasted about a week.
9
Effective vitamin support
1 people found this helpful
Excellent quality product with well-chosen ingredients. I faced no allergies or negative reactions. After a week, my intestinal function and overall metabolism improved. I experienced better nervous system functioning and found it to be effective.
7.5
Reduced allergies
I take it on an empty stomach every morning, and I’ve found my nasal allergies have significantly improved.
9
Supports allergy relief
3 people found this helpful
I've been taking Nattokinase for my respiratory allergies, following the advice that it aids sinus issues. Taking it after dinner has improved my digestion and allergies. I appreciate the quality and ingredients. I take it with water to avoid the taste, and it works well for me.
7.5
Sinus health benefits
3 people found this helpful
Nattokinase is renowned for its circulation benefits, but it also greatly aids sinus health. It thins mucus and alleviates post-nasal drip, allergies, and coughs, particularly beneficial during allergy season.
9
Seasonal allergy relief
I found this product particularly helpful for seasonal allergies, alongside calcium lactate and quercetin. Very satisfied with the results.
9
Improved overall well-being
1 people found this helpful
This product is excellent. The ingredients are well-selected, and I experienced no allergies or negative reactions. After a week, I noticed improvements in my hair, skin, and bowel function. I highly recommend adjusting the dosage based on age.
7.5
Allergy and pain relief
1 people found this helpful
My doctor recommended this product, as I am sensitive to many medications. It has effectively managed my allergies for a long time, and it also seems to help with arthritis pain.
References
- Suzuki K, Nakamura M, Sato N, Futamura K, Matsunaga K, et al. Nattokinase (Bac s 1), a subtilisin family serine protease, is a novel allergen contained in the traditional Japanese fermented food natto. Allergol Int. 2023;72:279. 10.1016/j.alit.2022.11.010
