Garden of Life Whole Food Vitamin C Code Raw Capsules 500mg

Vitamin C alleviates cold sores

Based on 3 Researches

Topical treatment of recurrent mucocutaneous herpes with ascorbic acid-containing solution.

Most Relevant Research

We investigated how an ascorbic acid-based solution could help treat recurrent cold sores, also known as mucocutaneous herpes. This study was carefully designed as a randomized, double-blind, placebo-controlled trial, which helps ensure the results are reliable and trustworthy.

Participants used a strong solution of Ascoxal, rich in vitamin C, applied to their cold sores multiple times on the first day of the outbreak. We monitored various symptoms daily, including the severity of scabs, redness, and blisters, comparing the experiences of those using the vitamin C solution to a placebo group.

Our findings were promising: the active treatment resulted in fewer days with scabbing and less severe symptoms overall. Moreover, those using the vitamin C solution showed reduced persistence of scabs compared to the placebo group, along with a lower frequency of detected herpes virus after treatment.

In conclusion, this brief course of vitamin C treatment appears to have significant clinical benefits against cold sores, opening the door for future research on more extensive and frequent treatment regimes.

9.5

Cold sores treatment

Most Useful Review

This product is the best I’ve used. I’ve been taking it regularly when unwell, and my sore throat quickly disappears without resulting in a cold. I also take it as a preventative measure during peak cold seasons. I purchased it for my 81-year-old mother, who is delighted—she hasn’t been sick this autumn, and her cold sores have vanished. Thanks to the producers for helping so many people; I wish you continued success in your work.

Gastritis

Vitamin C lessens oxidative stress

Based on 12 Researches

Protective effect of vitamin C on oxidative stress: a randomized controlled trial.

Most Relevant Research

We aimed to discover how vitamin C supplementation affects oxidative stress in individuals diagnosed with chronic gastritis. In this study, we looked at 244 Japanese patients suffering from atrophic gastritis. They were randomly assigned to receive either 50 mg or 500 mg of vitamin C every day for five years.

After analyzing the results, we found notable differences between the two groups. The high-dose group experienced a significant decrease in reactive oxygen species (ROS), suggesting that vitamin C may help reduce oxidative stress associated with chronic gastritis. In contrast, the low-dose group reported an increase in ROS levels. These findings prompt further interest in how vitamin C can protect against oxidative stress in similar conditions.

Overall, our study supports the idea that higher doses of vitamin C could have a beneficial effect on oxidative stress, particularly in those dealing with gastritis. This insight opens avenues for considering vitamin C as a potential supportive treatment for managing oxidative stress-related issues in digestive health.

9.5

Gentle on stomach

Most Useful Review

Miracle Vitamin. This is the only vitamin C that doesn't irritate my gastrointestinal tract. With my gastritis and pancreatitis, it's challenging to take other vitamins. This one is easily tolerated and well absorbed. I take it twice daily, and it supports my immunity effectively.

Asthma

Pleuran and Vitamin C improve asthma

Beneficial effects of pleuran on asthma control and respiratory tract-infection frequency in children with perennial asthma.

Most Relevant Research

We conducted a thorough investigation to examine how vitamin C, when combined with pleuran (a natural extract from mushrooms), influences asthma control and respiratory health in children with partially controlled perennial asthma. Our study was a double-blind, placebo-controlled clinical trial involving 230 children aged 7 to 17 years, split evenly into an active treatment group and a placebo group.

Over a 24-week period, children in the active group received both pleuran and vitamin C, while the placebo group received vitamin C alone. It was exciting to find that children younger than 12 years who received the combination treatment showed notable improvement in their control of asthma symptoms compared to those on placebo. Additionally, older children in the active group reported fewer respiratory infections, an important benefit for their overall health.

By the end of our 48-week study, we saw a significant improvement in asthma control in a high percentage of children receiving the active treatment. Notably, this combination appeared safe, with no serious side effects reported. Overall, our findings suggest that while vitamin C's isolated effects can't be fully assessed due to its combination with pleuran, the combined treatment offers promising benefits for managing asthma in children.

9.5

Symptom relief

Most Useful Review

Impressive quality and perfect size. This supplement, with its amazing mineral content, really benefited me; my symptoms vanished, and my deficiency was resolved. The taste is quite acceptable. It acts as a natural antihistamine and anti-inflammatory, making it the best for allergies, asthma, and air hunger.

Chronic Cough

Absence of bleeding gums

In my opinion, this is the best vitamin C available. I take it as advised by my doctor and as a supplement. Whole food vitamin C not only contains ascorbic acid but also components for absorption. Since starting it, my chronic cough has improved and my bleeding gums have ceased, which is significant for me.

Constipation

Vitamin C's impact on constipation

Feasibility study for a fully decentralized clinical trial in participants with functional constipation symptoms.

Most Relevant Research

We conducted a fully decentralized clinical trial to explore the effects of vitamin C on constipation symptoms. Participants who experienced functional constipation were randomly assigned to receive either Lactobacillus with vitamin C or vitamin C alone over a two-week treatment period. The study allowed us to gather data remotely, which is quite innovative and accessible.

Looking specifically at the results from the group that received vitamin C, we observed that while there was an increase in the frequency of bowel movements compared to the control group, the isolated effect of vitamin C itself wasn't entirely clear. The combination treatment appeared to improve bowel regularity, but it was difficult to determine how much vitamin C contributed independently to these results.

Additionally, we found that about 67% of participants were diligent in tracking their bowel diary entries, which helped ensure the reliability of our findings to an extent. Yet, a significant portion of the records were not kept as scheduled, highlighting potential hurdles in data collection for decentralized trials.

Overall, our observations suggest that while vitamin C, especially when paired with Lactobacillus, may provide some benefits for those struggling with constipation, we should exercise caution before attributing all improvements solely to vitamin C.

8.8

Helps keep regular

Most Useful Review

I love that this is natural. I've been taking it for 4 days without problems related to constipation. I take it on an empty stomach every morning. If anything, I think it's helped keep me regular. These are vitamins I feel good about taking.

Whooping Cough

Effective against cough

Great! It's easy on the stomach, with noticeable results. It helped relieve a horrible whooping cough that even prescription medications couldn't. I also give it to our 3-year-old dog for her skin issue; after one capsule for a few days, it was resolved. I can sprinkle it on her canned food, and she doesn't notice it's there. Very effective; I'm never without it.

Cold

Effectiveness of Vitamin C on Colds

Vitamin C for the common cold and pneumonia.

Most Relevant Research

We explored the effects of vitamin C on the common cold and pneumonia by examining a range of studies. Interestingly, research on animals suggests that vitamin C may have protective effects against infections. However, when it comes to preventing colds in the general population, taking more than 1 gram of vitamin C per day didn’t show significant benefits.

But there's a twist! Participants engaged in heavy physical activities saw their cold incidence reduced by half with vitamin C supplementation. Additionally, regular intake of 1 gram or more daily was linked to a 15% decrease in cold severity. While some therapeutic trials showed inconsistent results when vitamin C was taken after cold symptoms appeared, two studies did indicate that larger doses (6-8 grams per day) could effectively shorten the duration of colds compared to lower doses.

Our investigation also looked into pneumonia, but the studies were conducted in unique settings, such as a boarding school and military recruits. This makes it hard to generalize the findings to the wider population. Yet, some trials suggested benefits for pneumonia patients. Finally, the role of vitamin C in treating COVID-19 and sepsis remains unclear, with mixed results.

Given that vitamin C seems to alleviate symptoms and shorten the duration of colds, while being safe and affordable, it might be worth considering a dose of 6-8 grams per day to see if it helps at an individual level.

9.5

Quick cold recovery

Most Useful Review

Vitamin C is here to invigorate! I'm not venturing into any debate on real vitamin C versus ascorbic acid (do your own research!) but here’s my observation... First off, I'm sceptical about supplements. This hasn't transformed my life, but I managed to recover from a cold that was circulating in record time. My wife, her sister (a teacher, where these things often begin), and her sister’s boyfriend all caught it first; they were bedridden for nearly two weeks. I only felt a bit tired for one day. Unlike previous experiences with colds where I needed Dayquil and Nyquil for about a week, this time, I had just a hint of tiredness. I felt the onset, but it barely stopped me. I do hope the next cold passes just as swiftly!

Flu

Vitamin C mitigates flu pneumonia

Based on 5 Researches

A new mechanism of vitamin C effects on A/FM/1/47(H1N1) virus-induced pneumonia in restraint-stressed mice.

Most Relevant Research

We examined the effects of vitamin C on pneumonia caused by the influenza virus, specifically the H1N1 strain, in mice under stress. The study found that when exposed to restraint stress, the mice experienced increased mortality and more severe pneumonia symptoms.

However, by giving them oral vitamin C at doses of 125 and 250 mg/kg, we observed a significant reduction in these severe outcomes. Vitamin C seemed to modulate the expression of certain genes related to the immune response, such as MAVS and IRF3, and increased the expression of NF-κB, which plays a key role in the body's antiviral defense.

Our research suggested that vitamin C's protective effects might stem from its ability to inhibit excess cortisol production in the adrenal gland, which is often elevated due to stress. By lowering cortisol levels, vitamin C may help reduce susceptibility to influenza infections, making it a potential ally during the flu season, especially for those experiencing stress.

Through these findings, we highlighted a new mechanism for how vitamin C can be beneficial during influenza infections, particularly for those who are feeling overwhelmed.

9.5

Highly recommended vitamin

Most Useful Review

I absolutely rave about this product. When friends fall ill, I specifically recommend it. I’ve tried several other brands of Vitamin C without success; nothing has worked as well as this one. It's gentle on my stomach, and I haven't caught a cold or flu in over a year, despite not taking it daily. I take it when working with many people who often fall sick.

Allergies

Pleuran and Vitamin C aid asthma

Beneficial effects of pleuran on asthma control and respiratory tract-infection frequency in children with perennial asthma.

Most Relevant Research

We conducted a thorough evaluation of how vitamin C, when combined with pleuran, impacts asthma control and respiratory issues in children suffering from perennial asthma. The study was meticulously designed as a double-blind, placebo-controlled trial involving 230 children aged 7 to 17 years. This means that neither the participants nor the researchers knew who was receiving the active treatment or the placebo, ensuring the findings were reliable.

The results were promising, especially for children under 12 years. They showed significant improvements in asthma control compared to those receiving only the placebo treatment. Meanwhile, older children (12 years and above) experienced fewer respiratory infections with the combination treatment. Overall, by the end of the 48 weeks, a majority of children on the pleuran and vitamin C treatment reported better asthma control compared to those on the placebo.

While the combination of pleuran and vitamin C was indeed beneficial for managing asthma, we must note that the study did not specifically isolate the effect of vitamin C alone on allergies or asthma. Thus, it is hard to draw definitive conclusions about vitamin C's effectiveness independently from pleuran. However, the approach suggested that using these supplements together could offer a helpful boost in managing asthma symptoms.

9.5

Sleep improvement

Most Useful Review

These supplements help my ragweed allergies significantly when I wake up choking at night. Combined with Flonase and Allegra for severe instances, these are easy on an empty stomach and effectively reduce mucus without side effects. Highly recommended!

Anemia

Vitamin C aids anemia treatment

The Forgotten Disease in the 21st Century: Scurvy Outbreak in Hawassa Central Prison, Hawassa, Sidama, Southern Ethiopia, 2023.

Most Relevant Research

We observed a fascinating phenomenon related to vitamin C and anemia during a series of cases in a prison setting in Ethiopia. Specifically, we examined how scurvy, a disease caused by a lack of vitamin C, contributed to anemia among prisoners.

Our study focused on ten patients who were admitted for treatment, all of whom presented with some form of leg swelling or pain. After administering vitamin C in the form of ascorbic acid, we noted a significant increase in hemoglobin levels, rising from an average of 4.6 to 7.1 g/dL. This improvement indicates that vitamin C may play a crucial role in alleviating some anemia symptoms when the underlying cause is related to dietary deficiencies.

Additionally, through an observational study involving 67 other patients in the same prison, we confirmed that leg swelling and pain were common symptoms among those affected. With consistent therapeutic doses of vitamin C, all patients showed considerable improvement in their conditions.

Thus, we can conclude that vitamin C does seem to have a valuable effect on anemia caused by dietary deficiencies, particularly in high-risk environments like prisons. This finding encourages healthcare providers to remain vigilant about such nutritional deficiencies and highlights the importance of vitamin C in treatment.

9.5

Supports iron absorption

Most Useful Review

This is my second time taking it, and I believe it's the best vitamin C available, especially for treating anemia and boosting immunity. If this review was helpful, please give it a like.

Arthritis

Vitamin C's role in arthritis management

The role of vitamins D, B12, C, and K in modulating inflammation and disease management in rheumatoid arthritis: a comprehensive review.

Most Relevant Research

We explored the role of vitamin C in addressing arthritis symptoms, particularly its effect on joint inflammation. Vitamin C is known for its antioxidant properties, and we found that it plays a crucial role in collagen synthesis. This feature is important as collagen forms the structural basis of our joints.

What excited us was the possibility that vitamin C could help reduce inflammation in patients with rheumatoid arthritis. Given that inflammation is a major factor in the discomfort and damage associated with this condition, any reduction could significantly enhance the quality of life for those affected.

However, while vitamin C shows promise due to its supportive functions, we must remember that the evidence concerning its direct effectiveness on arthritis specifically is still evolving. The correlation between vitamin C intake and reduced joint inflammation points to a beneficial role, but more detailed studies are necessary to solidify these findings and determine optimal dosages.

Overall, our review highlights that while vitamin C may indeed support joint health and aid in managing inflammation, further research is essential to fully understand its impact and to evaluate how it can be integrated into arthritis management strategies effectively.

9.5

Arthritis relief

Most Useful Review

Very excellent. I have arthritis, and it significantly relieves my pain when I use it twice daily.

Bone Pain

This is very good; Vitamin C has alleviated my shoulder and neck bone pain and tension.

Chronic Fatigue Syndrome

Vitamin C aids immune function

Based on 5 Researches

The clinical course of interstitial pneumonia alias chronic fatigue syndrome under the control of megadose vitamin C infusion system with dehydroepiandrosterone-cortisol annex.

Most Relevant Research

We examined how a combination of megadose vitamin C infusions and other treatments might help manage chronic fatigue syndrome, particularly in the context of interstitial pneumonia. Our findings were based on nearly a decade of treating patients, allowing us to gather valuable insights.

We observed that the long-term use of this treatment system significantly reduced the risk of pneumonia recurrence. It also appeared to help prevent the emergence of certain cancers in older patients suffering from interstitial pneumonia. Surprisingly, we found a link between interstitial pneumonia and an increased risk of depression, likely driven by prolonged glucocorticoid use.

While some patients showed promise under this treatment, those battling both interstitial pneumonia and depression responded less favorably. We suggested that increasing the amount of dehydroepiandrosterone in the treatment could be beneficial. Throughout our experience, we noted that the characteristics of chronic fatigue syndrome align closely with those of interstitial pneumonia, arguing against the notion that they should be viewed as separate conditions.

Overall, our approach not only alleviated inflammation but did not suppress the fibrotic processes in the long run. We made modifications to the treatment to lower the risks of vascular complications. The main strength of our treatment lies in creating a hormonal environment that helps tackle immune deficiencies using vitamin C, which faces lower resistance in the body compared to steroid treatments.

8.8

Improved immunity

Most Useful Review

My life has transformed since I began taking vitamin C daily. Previously, I suffered from chronic fatigue syndrome and frequent colds. Regular vitamin C intake has boosted my immunity significantly, with only occasional mild colds now. I have tried various brands from iHerb, and all have been effective. I'm grateful to those who support my health.

Irritable Bowel Syndrome

Supports IBS treatment

This is an outstanding vitamin C complex product. While it's currently unavailable, I believe it's essential for supporting the immune system and digestive health. It significantly aids in reducing irritable bowel syndrome symptoms and enhances mood. When combined with iron supplements, it boosts iron absorption and helps those with anaemia. It features fantastic antioxidants that combat free radicals and support organ function. Overall, it's exceptional for improving health and wellbeing.

Knee Pain

Vitamin C for knee pain relief

Skeletal manifestations of scurvy: a case report from dubai.

Most Relevant Research

We observed an intriguing case involving a 4.5-year-old boy who developed significant knee pain due to a rare nutritional deficiency, scurvy. This condition stemmed from his exclusive intake of meat over the past two years, resulting in skeletal issues and inflammation in multiple joints, including his knees.

Upon examination, the child exhibited several symptoms, including pain, swelling, and an inability to walk. Standard blood tests primarily indicated anemia, but X-rays revealed alarming conditions related to scurvy, such as delayed bone age and severe osteopenia. This alarming picture led us to the conclusion that vitamin C deficiency was the underlying culprit behind his knee pain and skeletal issues.

After initiating vitamin C therapy, we noted a remarkable reduction in pain and swelling over the next two months. The child’s condition improved significantly, allowing him to walk again, and follow-up X-rays confirmed the positive changes in his bone health. This case clearly illustrates how vitamin C can effectively alleviate knee pain related to scurvy and reinforces the importance of proper nutrition for overall skeletal health.

9.5

Improved knee pain

Most Useful Review

I continually order this for my mother, who is over fifty. She has noticed a reduction in her knee pain.

Leg Cramps

Leg cramps treatment comparison

Calcium and magnesium status in pregnant women. A comparison between treatment with calcium and vitamin C in pregnant women with leg cramps.

Most Relevant Research

We explored the effects of vitamin C on leg cramps in a group of 60 pregnant women through a double-blind trial. Participants received either calcium or vitamin C (1 g twice daily) as treatment. Our observations revealed that there was no significant difference in clinical improvement between the two treatment groups.

Notably, 14 patients experienced complete relief from symptoms, while 27 reported significant improvement regardless of which treatment they received. Unfortunately, 17 participants found their symptoms unchanged, and only two noticed an increase in leg cramps during the treatment period.

Throughout the study, we measured serum levels of total and ionized calcium, total magnesium, and albumin, but these parameters did not show significant changes in either treatment group. We also didn’t identify any biochemical differences when comparing the effectiveness of vitamin C and calcium for alleviating cramps.

Ultimately, our findings suggest that vitamin C may not be an effective solution for leg cramps in pregnant women, as both treatments yielded similar results with minimal biochemical changes.

9.5

Reduced leg cramps

Most Useful Review

The natural and organic C-complex is derived from non-GMO vegetables and fruits and is free from ascorbic acid. After using it, I feel invigorated. I take two capsules each morning before breakfast and have noticed a significant reduction in my leg cramps and joint pain upon waking.

Pneumonia

Effective pneumonia relief

Great! Easy on the stomach and the effects are noticeable. It helped eliminate a dreadful pneumonia cough that not even prescription medications could address. I also give it to our three-year-old dog, who had a skin issue that resolved after just one capsule for a few days. I can sprinkle it on her canned food without her noticing. Very effective. I never want to be without it.

Prostate Cancer

Vitamin C shows promise in cancer treatment

Based on 14 Researches

Pharmacological Vitamin C Treatment Impedes the Growth of Endogenous Glutamine-Dependent Cancers by Targeting Glutamine Synthetase.

Most Relevant Research

We examined how vitamin C (VC) affects prostate cancer cells, particularly those reliant on glutamine for growth. Our study involved both prostate cancer cell lines and mouse models to understand the therapeutic potential of VC in this context.

We discovered that vitamin C has the ability to target an enzyme known as glutamine synthetase (GS), crucial for cancer cell survival. By degrading GS, VC induces oxidative stress, which appears to be detrimental to the cancer cells. We used both traditional lab approaches and more advanced imaging techniques to monitor the treatment's effectiveness, and found a direct correlation between GS levels and the cytotoxic effects of VC.

Not only did our experiments demonstrate that VC boosts the production of reactive oxygen species (ROS), but they also revealed that its effects could be mitigated by antioxidants, highlighting its mechanism of action. Particularly compelling were results from the mouse models, where VC treatment showed more pronounced effects in cancer cells overexpressing GS, suggesting a tailored approach to treatment might be effective.

Overall, these findings point to the potential of vitamin C as a novel treatment option for endogenous glutamine-dependent prostate cancers, emphasizing its role in targeting the metabolic pathways vital for tumor cell growth.

9.5

Immune system boost

Most Useful Review

Vitamin C is a powerful antioxidant that combats free radicals, supporting health and prolonging youth. It plays a crucial role in muscle gain, wound healing, and enhances absorption of iron and calcium. For me, vitamin C is vital for detoxifying the body and regulating adrenal function, thereby helping me manage daily stress. A deficiency leads to gum bleeding, hair loss, and delayed wound healing, among other issues. I find Garden of Life's Vitamin Code effective, especially with its probiotics. While it’s slightly pricey, it offers great benefits, particularly against prostate cancer.

Sinusitis

Vitamin C aids chloride transport

Effect of L-ascorbate on chloride transport in freshly excised sinonasal epithelia.

Most Relevant Research

We explored the effects of L-ascorbate, commonly known as Vitamin C, on chloride transport in sinonasal epithelial tissues. This research is particularly significant as it addresses the common condition of chronic rhinosinusitis (CRS) and its potential link to the function of the cystic fibrosis transmembrane conductance regulator (CFTR) — a key chloride ion channel.

During our investigation, we utilized freshly excised sinonasal tissues from both normal individuals and patients suffering from CRS. The tissues were carefully prepared and tested to understand how L-ascorbate influenced chloride secretion. Our findings revealed that the application of L-ascorbate notably enhanced chloride secretion in these tissues.

This is important because optimal chloride transport is essential for maintaining healthy mucosal surfaces and effective mucociliary clearance. Therefore, since decreased chloride secretion could lead to the worsening of sinus conditions, L-ascorbate presents a promising avenue for therapeutic intervention in improving mucociliary clearance for those affected by chronic sinus issues.

9.5

Improved throat comfort

Most Useful Review

I switched from Quali-C supplements to this vitamin C and noticed a remarkable improvement; my throat no longer hurts, even when I breathe through my mouth due to sinusitis, and I don’t tire as easily. The capsule is a bit large, but it’s manageable once you get used to it.

Ulcer

Vitamin C reduces gastric ulcers

Based on 5 Researches

Vitamin C modulates adrenaline-augmented gastric injury via cardiac troponin/creatine kinase pathway in Wistar rats.

Most Relevant Research

We observed the potential benefits of vitamin C in managing gastric ulcers under conditions of myocardial injury, which was induced using adrenaline in our study. Thirty Wistar rats were carefully divided into five groups, ensuring a control group for comparison.

The rats that received adrenaline alone showed increased gastric secretions and elevated markers related to heart injury. However, those pre-treated with vitamin C experienced a notable reduction in ulcer severity and excessive gastric secretions.

Interestingly, when we administered vitamin C before the adrenaline exposure, we found that it significantly decreased both the volume of gastric juice and total acidity, while also enhancing some protective factors. In essence, our research indicates that vitamin C may play a protective role in gastric health, particularly amid the stressful conditions created by adrenaline.

9.5

Ulcer healing effect

Most Useful Review

The anti-inflammatory effect is excellent. I have found this natural vitamin C supplement to be vital for long-term use. After taking high doses for three days, my mouth ulcer healed completely, and the inflammation subsided. It's challenging to obtain enough vitamin C from food alone, making this supplement the best choice. Its natural ingredients are safe and reliable, ensuring quality and effectiveness.

Rosacea

Rosacea treatment with vitamin C

[Angioprotectors in the treatment of rosacea].

Most Relevant Research

We explored the effectiveness of Rutin Forte, a treatment that includes long-acting vitamin C along with zinc and selenium, in managing rosacea, particularly in its erythematous stage. Our study included 30 patients—20 women and 10 men, aged 25 to 50—who were divided into two groups. One group received standard treatments like antibiotics and topical therapies, while the other group received the same treatments along with Rutin Forte for 2 to 3 months.

Over a 12-month observation period, we observed significant improvements in the group that received Rutin Forte. This group showed a notable reduction in erythema, the redness associated with rosacea, and intriguingly, there were no relapses of the condition. Conversely, the standard treatment group experienced recurrences of rosacea by the third month of follow-up, and their reduction in erythema was less pronounced.

This indicates that Rutin Forte, likely due to the vitamin C it contains, might play a beneficial role in treating and preventing rosacea symptoms, particularly in stubborn cases. Overall, our findings suggest that incorporating vitamin C into rosacea treatment can be quite effective.

9.5

Skin condition improved

Most Useful Review

Best vitamin C for skin and energy! I have rosacea and melasma, and read that vitamin C and E are beneficial. After taking these internally, my skin looks fantastic – much less irritated and luminous. I feel better than ever, with clear thinking and balanced energy. These vitamins have truly helped me, and I'm very grateful!

Anxiety

Vitamin C alleviates anxiety in autism

Vitamin C and Gallic Acid Ameliorate Motor Dysfunction, Cognitive Deficits, and Brain Oxidative Stress in a Valproic Acid-Induced Model of Autism.

Most Relevant Research

We set out to explore how vitamin C influences anxiety-like behaviors in a model of autism caused by valproic acid (VPA). In our study, we used fourteen female rats that underwent specific treatments to induce autism in their offspring. After a period of observation, we treated male pups with daily injections of vitamin C for four weeks. Then, we assessed their behavior to see if there were any changes in anxiety levels.

Our findings suggested that vitamin C significantly reduced anxiety-like behaviors in these rats. This outcome is particularly promising considering that autism often brings associated anxiety. By measuring various brain oxidative stress markers, we also noted improvements in mental functioning and motor skills after vitamin C treatment. Overall, our work underscores the potential benefits of vitamin C as a supportive treatment for anxiety-related issues in autism, indicating a pathway for future research and therapeutic strategies.

8.8

Enhanced mood support

Most Useful Review

A fantastic product with high demand, making it often unavailable. This vitamin C complex significantly benefits my immunity and digestive health, alleviates anxiety, and boosts my mood. It works wonderfully alongside Iron supplements, improving iron absorption and aiding those with anaemia. The antioxidants effectively combat free radicals, further enhancing overall body function. I highly recommend it, though availability is a concern.

Breast Cancer

Vitamin C may reduce breast cancer

Based on 9 Researches

The association between vitamin C and breast cancer, prostate cancer and colorectal cancer: A systematic review and meta-analysis.

Most Relevant Research

We examined the relationship between vitamin C and breast cancer through a systematic review and meta-analysis of various studies. By analyzing data from both cohort and case-control studies, we aimed to ascertain how dietary vitamin C affects breast cancer risk.

Our findings reveal an interesting trend. While we found that dietary vitamin C consumption was inversely related to breast cancer risk in case-control studies, showing a significant reduction in breast cancer incidence, the results from cohort studies presented a pooled relative risk (RR) of 0.99. This indicates no substantial association in those comprehensive, long-term observations.

Moreover, our review highlighted that there was no notable connection between vitamin E and breast cancer, suggesting that more research is needed to understand the complete impact of these nutrients. Overall, while the case-control study results are promising, the cohort studies suggest that more nuanced insights might be necessary before making solid conclusions about vitamin C as a preventive measure against breast cancer.

8.5

Supports breast cancer

Most Useful Review

Vitamin C is an exceptional antioxidant that combats free radicals, enhances health, and provides protection against breast cancer. It aids in protein synthesis, muscle gain, and speeds up wound healing. Vitamin C is crucial for detoxifying the body and regulating adrenal gland function, enhancing hormone production and stress resistance. A deficiency can lead to significant health issues, including bleeding gums and poor wound healing. I found no drawbacks to Garden of Life's Vitamin Code, which is absorbed well and helps during illness. Despite the cost, I highly recommend it.

Cancer

Vitamin C enhances immune response

Likely Very Effective

Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response.

Most Relevant Research

We delved into how vitamin C might influence cancer treatment, focusing on its effects on the immune system. Our findings revealed that vitamin C directly modifies certain proteins, leading to a new type of protein change called vitcylation. This process specifically affects a protein known as STAT1.

By modifying STAT1, vitamin C enhances its ability to signal for immune responses. We found that this modification occurs in both controlled environments and living cells, depending on factors like dosage and acidity. As a result of vitcylation, the action of STAT1 is improved, which activates important immune responses in tumor cells and boosts the expression of molecules that help the immune system recognize and attack cancer cells.

Interestingly, this research sheds light on the potential of vitamin C as a treatment that not only affects cancer directly but also empowers the body’s own defenses. These insights pave the way for new approaches to cancer therapy that leverage the immune system in conjunction with vitamin C.

8.8

Strengthened immune system

Most Useful Review

I am over 70 and my immune system is greatly compromised. Living with someone diagnosed with COVID tested my immune strength. I was fortunate enough to test negative after using vitamins C, D3, and zinc. I've terminal cancer, and I highly recommend this raw vitamin regime for others.

Hashimoto

Vitamin C may lower hypothyroidism risk

Association between total vitamin C intake and hypothyroidism among Hashimoto thyroiditis: National Health and Nutrition Examination Survey, 2007-2012.

Most Relevant Research

This study aimed to explore whether vitamin C intake could have an impact on hypothyroidism in individuals with Hashimoto thyroiditis (HT). We analyzed data from the National Health and Nutrition Examination Survey, focusing on participants from 2007 to 2012.

Our findings revealed an interesting association. We observed that higher total vitamin C intake was linked to a lower likelihood of hypothyroidism in those with HT. Specifically, individuals in the highest quartile of vitamin C intake had about 60% lower odds of experiencing hypothyroidism compared to those in the lowest quartile. This suggests that a greater intake of vitamin C, ranging from 4.57 to 1258.9 mg per day, might be beneficial for those affected by this condition.

Additionally, this association held true across different age groups and genders. Overall, we found that increasing vitamin C consumption might offer protective effects against the onset of hypothyroidism in Hashimoto thyroiditis patients.

8.8

Recommended vitamin C

Most Useful Review

Hashimoto's patients ought to take this vitamin C product, and I feel it’s perfectly fine to combine it with NORD brand!

High Cholesterol

Vitamin C reduces cholesterol levels

Based on 6 Researches

Effect of Using Vitamin C Supplementation on Performance, Blood Parameters, Carcass Characteristics and Meat Quality of Broiler Chickens Under Heat Stress Condition: A Meta-Analysis.

Most Relevant Research

We explored how vitamin C supplementation affects cholesterol levels in broiler chickens, particularly under heat stress conditions. Through a thorough meta-analysis of 35 studies conducted between 1985 and 2023, we assessed various performance metrics, including blood parameters, carcass characteristics, and overall meat quality.

Our findings revealed that vitamin C significantly reduced cholesterol levels in the broiler chickens subjected to heat stress. Specifically, the study reported a notable decrease in cholesterol concentrations, with a standard mean difference of -0.976, indicating a strong beneficial effect of vitamin C in managing high cholesterol.

Additionally, we noticed improvements in body weight and average daily gain among chickens receiving vitamin C when compared to those that did not. While vitamin C did not significantly impact feed intake or breast meat quality, it emerged as a valuable antioxidant that can help lower blood triglycerides and reduce cholesterol, thus promoting better overall health and growth in broilers during stressful conditions.

Ultimately, this meta-analysis supports the use of vitamin C at a recommended dosage of 250 mg/kg as an effective growth promoter and antioxidant in broiler diets under heat stress, directly influencing cholesterol management.

9.5

Effective for cholesterol

Most Useful Review

I have been consuming this for a month, and it has effectively resolved my sinus and skin allergy issues within the first week. This brand uniquely uses real whole foods without fillers, and I highly recommend it for anyone dealing with high cholesterol.

Lung Cancer

Vitamin C reduces lung cancer spread

Vitamin C Inhibited Pulmonary Metastasis through Activating Nrf2/HO-1 Pathway.

Most Relevant Research

We explored the effects of vitamin C on lung cancer, particularly its ability to inhibit pulmonary metastasis—meaning the spread of cancer to the lungs. Using an H22 pulmonary metastasis mouse model, we observed that vitamin C administration, both intraperitoneally and orally, showed promising results.

Through the research, we found that intraperitoneal injections of vitamin C led to an increase in crucial proteins like Nrf2 and HO-1, which are known to help combat cancer. This process resulted in increased cell death in cancer cells through DNA damage and apoptosis, mimicking the effects seen when using pro-oxidant treatments in cells lacking the p53 protein—a critical tumor suppressor.

Furthermore, oral vitamin C not only activated these protective pathways but also spurred the expression of p53 in healthy tumor cells, showcasing its potential as an antimetastatic agent. We noted that vitamin C reduced the proliferation and migration of lung cancer cells while being gentler on normal cells, suggesting a safer therapeutic profile.

Overall, this study highlights vitamin C's dual role in both bolstering the body's defenses against cancer and directly inhibiting the spread of lung cancer, paving the way for its consideration in clinical treatments for pulmonary metastasis.

8.8

Improved lung health

Most Useful Review

Vitamin C is a potent antioxidant that combats free radicals, prolonging youth and aiding in health. It is vital for athletes for muscle gain and assists in wound healing, while enhancing iron and calcium absorption. This vitamin supports toxin elimination and adrenal function, crucial for hormone production and stress management. Deficiency can lead to issues like bleeding gums and hair loss. I've noticed positive effects, especially with lung cancer treatment when taking Garden of Life's vitamin C. Their vitamins are well absorbed and contribute to overall wellness, and part of the sales supports children's food aid.

Osteoporosis

Vitamin C may support bone health

The Positive Association of Plasma Levels of Vitamin C and Inverse Association of VCAM-1 and Total Adiponectin with Bone Mineral Density in Subjects with Diabetes.

Most Relevant Research

We explored the connection between vitamin C levels and bone mineral density (BMD) in individuals with diabetes. By examining a group of 74 diabetic patients alongside 26 age-matched non-diabetic controls, we focused on how vitamin C intake could potentially influence bone health. Our goal was to see if higher vitamin C levels were associated with improved BMD and whether this effect might be related to decreases in certain inflammatory markers like VCAM-1 and adiponectin.

The results were quite promising. We observed a positive link between circulating levels of vitamin C and BMD, suggesting that higher vitamin C might indeed contribute to healthier bones. Notably, we found that this beneficial effect was closely tied to lower levels of inflammatory markers in the blood. This indicates that vitamin C might help not just in improving BMD but also in lowering inflammation, which can be particularly valuable for those living with diabetes.

Overall, our findings highlight the importance of maintaining adequate vitamin C levels as a potential strategy to reduce the risk of osteoporosis in individuals with diabetes. Incorporating vitamin C in the diet could be a simple yet effective way to support bone health while also combatting underlying inflammation.

8.8

Supports osteoporosis treatment

Most Useful Review

Clean vitamin C is a whole food supplement that's easy to take. I use it alongside other supplements to aid my osteoporosis. I highly recommend it.

Colitis

Great product! We purchased this because of its beneficial ingredients. It works well for me, my husband who suffers from colitis, and my daughter with a sensitive stomach. I've noticed significant differences on days when I miss taking it. Undoubtedly, the best product we've tried after experimenting with dozens over the past ten years.

Brain Tumor

Vitamin C impacts glioblastoma progression

Based on 12 Researches

Vitamin C deficient reduces proliferation in a human periventricular tumor stem cell-derived glioblastoma model.

Most Relevant Research

We aimed to understand how a lack of vitamin C influences the growth of glioblastoma, one of the most aggressive types of brain tumors. Using guinea pigs, we tested the effects of a vitamin C-deficient diet on tumor growth caused by two different human glioblastoma cell lines, U87-MG and HSVT-C3.

Through this study, we observed that the absence of vitamin C significantly hindered tumor proliferation in both models. Notably, we found that vitamin C deficiency reduced factors associated with tumor growth, such as vasculature and immune cell infiltration, particularly in the HSVT-C3 cells, which are known for their stem cell-like properties.

Our findings suggest that vitamin C plays a crucial role in supporting tumor growth, and when absent, it can lead to a notable reduction in glioblastoma progression. This emphasizes the potential importance of maintaining adequate vitamin C levels for patient outcomes in brain tumor scenarios.

9.5

Strengthens immunity

Most Useful Review

Raw Vitamin C helps strengthen the immune system through its antioxidant properties. It also aids the body in reducing the risk of tumours by inhibiting the production of carcinogenic substances. I highly recommend it!

Heart Attack

Antioxidants tested for heart attacks

Safety and Pharmacokinetics of a Combined Antioxidant Therapy against Myocardial Reperfusion Injury: A Phase 1 Randomized Clinical Trial in Healthy Humans.

Most Relevant Research

In a recent clinical trial, we examined how a combination of antioxidants, including vitamin C, affects heart attack recovery. This study involved healthy participants who received either a blend of antioxidants or a placebo through an intravenous infusion. We measured the levels of vitamin C and other components in the blood, looking for signs of oxidative stress and monitoring any adverse effects.

Our findings showed that the antioxidant combination significantly increased vitamin concentrations compared to the placebo group. Moreover, we observed that this therapy seemed safe, with only mild, non-serious side effects reported in a small number of participants.

While antioxidants like vitamin C have been linked to health benefits, this study focused primarily on their safety and levels in the blood during a heart-related procedure. Although promising, we cannot definitively say that this approach improves outcomes for heart attack patients just yet. More research will be needed to explore its effectiveness further.

Strengthens blood vessels

Most Useful Review

Vitamin C aids in normalising metabolism, fortifying blood vessel walls, and reducing the formation of harmful nitrosamines. It supports the nervous system and heart, participating in neurotransmitter synthesis. The quality is excellent, the size is appropriate, and my family's health has improved. The ingredients are clearly listed on the packaging, which is practical. I noticed results on my face.

Nausea

Vitamin C ineffective against nausea

Very Likely Ineffective

The Role of hCG and Histamine in Emesis Gravidarum and Use of a Chewing Gum Containing Vitamin C as a Treatment Option: A Double-Blinded, Randomized, Controlled Trial.

Most Relevant Research

We explored the effects of vitamin C as a treatment for nausea and vomiting in pregnancy, also known as emesis gravidarum. Our study involved 111 participants, who were given either vitamin C-containing chewing gum, a placebo, or no treatment at all. We monitored them over two follow-up visits in early pregnancy to assess their symptoms.

While we measured various factors that could influence nausea—including hormone levels like hCG and DAO—our findings showed that the chewing gum did not effectively reduce nausea symptoms compared to the placebo or no treatment. Specifically, the vitamin C gum was not associated with any significant alleviation of nausea or vomiting.

Interestingly, we found that elevated levels of hCG were linked to increased nausea severity. In contrast, higher levels of DAO appeared to have a protective effect against symptoms. Additionally, elevated thyroxine and pyridoxine levels correlated with worsened nausea.

Overall, while vitamin C is often highlighted for its health benefits, our results suggest it does not play a significant role in treating nausea during pregnancy. This study highlights the complexities behind nausea in pregnancy, indicating that further research is necessary to uncover effective treatment options.

9.5

No nausea experienced

Most Useful Review

Trusted brand with clean, non-toxic ingredients earns this product 5 stars. I have reordered this vitamin and others from Garden of Life. The organic and raw components aid absorption without causing nausea. I prefer capsules to tablets; they seem a better delivery method and digest well.

Sleep Apnea

Vitamin C improves sleep apnea endothelial function

Antioxidant vitamin C improves endothelial function in obstructive sleep apnea.

Most Relevant Research

We evaluated how vitamin C might improve endothelial function in patients with obstructive sleep apnea (OSA). In our study, we compared 10 individuals with untreated OSA to 10 matched control subjects without sleep issues. We measured how well blood vessels reacted to increased blood flow, known as flow-mediated dilation (FMD), using ultrasound before and after administering vitamin C.

Our findings revealed a significant difference: baseline FMD was lower in OSA patients compared to the control group. However, after an intravenous injection of vitamin C, the FMD in OSA patients improved dramatically, reaching levels similar to those seen in the healthy controls. Interestingly, vasoreactivity in the control subjects remained unchanged.

These results suggest that oxidative stress might be a key factor contributing to the endothelial dysfunction experienced by individuals with OSA. The positive response to vitamin C opens up exciting possibilities for exploring antioxidant treatments in managing cardiovascular issues related to OSA.

7.5

Improved mood

Most Useful Review

I noticed no smell and found it easy to sleep with less stress, which has enhanced my mood. The size is good, and it's straightforward to use. The quality is commendable, the packaging is nice, and knowing it contains clean ingredients adds to my comfort. Importantly, this has helped me manage my sleep apnea effectively without any unpleasant taste.

Autoimmune Disorder

Vitamin C impacts autoimmune response

Ascorbic acid alleviates rheumatoid arthritis by inhibiting the production of autoantibodies.

Most Relevant Research

We investigated how vitamin C, also known as ascorbic acid, might impact autoimmune disorders like rheumatoid arthritis. Through a study involving a mouse model of collagen-induced arthritis, we administered vitamin C or a placebo solution and observed the effects on the immune response and disease progression.

Notably, the research showed that mice given vitamin C experienced a significant delay in the onset of arthritis and a reduction in disease severity. This suggests that vitamin C can play a critical role in managing autoimmune conditions by minimizing the production of autoantibodies, which are harmful antibodies that mistakenly attack the body's tissues.

Our findings revealed that vitamin C reduced the number of plasma cells and decreased antibody production in response to immunization. This indicates that vitamin C influences the immune system's response at a cellular level, helping to prevent the emergence of autoreactive plasma cells. We also discovered that the mechanism behind this effect involved inhibiting the Stat3 signaling pathway, leading to less activation of autoreactive immune components.

Ultimately, these results highlight the potential of vitamin C not just as a nutrient, but as a strategic tool in managing autoimmune disorders. By simply supplementing with vitamin C, there may be a way to intervene positively in the progression of diseases like rheumatoid arthritis.

9.5

Acute respiratory relief

Most Useful Review

Vitamin C has helped me considerably throughout winter and spring. At the first sign of a cold, I increased my dose and felt the symptoms disappear by morning. Given my tendency for acute respiratory infections, this vitamin has proven exceptional, and I've had fewer illnesses these past two seasons. I'm definitely ordering more.

Bruise

Vitamin C improves bruising symptoms

Based on 9 Researches

Scurvy in the Modern World: Extinct or Not?

Most Relevant Research

We explored how vitamin C can impact bruising, particularly in individuals experiencing a deficiency. The research highlighted a case involving an elderly woman who faced challenges such as weakness, easy bruising, and fatigue due to a lack of this vital nutrient.

After beginning treatment with vitamin C supplements, we observed significant improvements in her symptoms, emphasizing the importance of this vitamin in healthier skin and tissue repair. It showcased that scurvy, a condition rooted in vitamin C deficiency, can still occur today, especially in certain at-risk populations.

This case reminds us that while scurvy might seem like a relic of the past, it can still affect modern individuals. Skin issues like easy bruising can sometimes signal deeper dietary concerns that need addressing, especially in older adults.

9.5

Effective treatment

Most Useful Review

I am now on my second jar as advised by a nutritionist. The bruises and bleeding gums have disappeared. I take it with food and feel no discomfort. I can definitely recommend it; there is a noticeable effect.

Influenza

Vitamin C's unclear influenza impact

Based on 6 Researches

The Role of Some Vitamins in Respiratory-related Viral Infections: A Narrative Review.

Most Relevant Research

We explored the relationship between vitamin C and influenza, delving into various studies conducted from 2000 to June 2021. In our analysis of the research, we found eleven studies that specifically examined the effects of vitamin C on influenza.

While some of these studies reported positive outcomes, we should note that the isolated benefits of vitamin C can be hard to determine. This is primarily because some studies included additional treatments, making it difficult to draw definitive conclusions about vitamin C alone.

Overall, we observed that while there is some interest and preliminary evidence regarding the efficacy of vitamin C in preventing or treating influenza, its stand-alone effectiveness remains somewhat unclear.

Continued research should help clarify how much vitamin C can truly contribute to combating influenza.

8.8

Strengthens immunity

Most Useful Review

Vitamin C is fantastic, especially for influenza symptoms and boosting immunity.

Reflux

Vitamin C aids omeprazole therapy

Antioxidant pre-treatment prevents omeprazole-induced toxicity in an in vitro model of infectious gastritis.

Most Relevant Research

We aimed to understand how Vitamin C could help with the toxicity caused by omeprazole, a common treatment for conditions like gastroesophageal reflux disease (GERD) and gastritis. During our study, we examined gastric cells from rabbits to see how Vitamin C, alongside other antioxidants, could protect these cells from damage caused by omeprazole.

We found that both omeprazole and another thiol-oxidant, monochloramine, significantly reduced cell viability. Interestingly, the toxicity from omeprazole occurred independently from monochloramine. However, we observed that using Vitamin C effectively protected the gastric cells from this injury, maintaining their function without interfering with omeprazole's intended effects.

This suggests that incorporating Vitamin C into treatment plans for people using proton pump inhibitors (PPIs) like omeprazole could be beneficial. Ultimately, our research highlights the potential of using antioxidants to mitigate the adverse effects often associated with medication for reflux and related conditions.

9.5

No reflux issues

Most Useful Review

I found this vitamin C to be the only one my husband can tolerate. He suffers from severe gastritis, and with other brands, he suddenly experiences reflux. This vitamin C does not cause that reaction.

Cardiovascular Disease

Vitamin C enhances NK cell proliferation

Based on 4 Researches

Proliferation capability of natural killer cells upon cytokines stimulation correlated negatively with serum lactate dehydrogenase level in coronary artery disease patients.

Most Relevant Research

We explored the effects of vitamin C on natural killer (NK) cell activity in patients with coronary artery disease (CAD). Our research involved isolating NK cells from 29 CAD patients and treating them with various stimulatory factors, including ascorbic acid—better known as vitamin C.

What we found was quite interesting: when NK cells were treated with ascorbic acid, there was a significant increase in their ability to proliferate. This meant that the NK cells were more active and potentially more effective in responding to threats in the body, which is vital for those dealing with heart conditions.

Furthermore, we measured serum lactate dehydrogenase (LDH) levels, discovering a negative correlation between LDH and NK cell activity. Higher LDH levels seemed to indicate lower proliferation capability in NK cells influenced by interleukins.

Overall, our study suggests that vitamin C could play a positive role in enhancing immune function in CAD patients by promoting NK cell proliferation. However, it's important to note that while vitamin C shows promise, further research is needed to fully understand its impact on cardiovascular health and immune regulation.

5.5

Gut health benefits

Most Useful Review

Vitamin C isn't just for colds; it greatly benefits cardiovascular disease. It maintains a healthy balance of gut bacteria and enhances gut barrier function, which helps absorb nutrients. I learned that food sources like oranges and peppers are excellent ways to get the recommended daily intake. It's essential, especially since my body can't produce it naturally. Although high doses can cause digestive issues, the positive effects on gut health and its role in mitigating cardiovascular disease are clear.

Diarrhea

Vitamin C improves diarrheic calf health

Does vitamin C supplementation in milk improve growth and health of diarrheic calves?

Most Relevant Research

We investigated how adding vitamin C to milk influences the growth and health of young calves, particularly those experiencing diarrhea. The study involved 48 Holstein calves, which were sorted into two groups based on their health status: healthy calves and those with diarrhea. Each calf was fed the same amount of pasteurized milk and monitored until they reached 74 days of age.

Calves that received vitamin C showed an impressive increase in weight by weaning—74.3 kg compared to 72.2 kg for those without vitamin C. Additionally, calves treated with vitamin C demonstrated improved blood antioxidant levels, suggesting better overall health. Notably, calves suffering from diarrhea benefitted significantly from the vitamin C, needing fewer days of medication for treatment compared to those who did not receive the supplement.

The research highlights that vitamin C can play a critical role in supporting the health of calves during episodes of diarrhea. This is especially relevant for those that faced even mild cases early in life, as they seemed to gain the most benefits from the supplementation. Overall, it appears that vitamin C can positively impact both growth and health in calves suffering from diarrhea.

9.5

No stomach issues

Most Useful Review

I usually struggle with vitamin C products, as they often give me diarrhoea within a few hours due to my digestive issues. However, this product does not cause that problem and has effectively helped me strengthen my immune system. I'm very pleased to have found it.

Acne

Vitamin C shows effectiveness for acne

Based on 16 Researches

Sodium L-ascorbyl-2-phosphate 5% lotion for the treatment of acne vulgaris: a randomized, double-blind, controlled trial.

Most Relevant Research

In our recent study, we set out to explore the effectiveness of a 5% sodium L-ascorbyl-2-phosphate lotion, a stable form of vitamin C, for treating acne. We conducted a double-blind, controlled trial with 50 participants over 12 weeks, where half used the vitamin C lotion and the other half received a placebo.

Our findings revealed significant improvements in acne symptoms for those using the vitamin C lotion compared to the placebo group. We measured outcomes through various assessments, including a global evaluation by investigators and self-reported assessments by the subjects, along with lesion counts.

The results showed that the vitamin C lotion was not only effective but also well-tolerated, with side effects similar to those seen with the placebo. This adds a promising tool to the options available for acne treatment, suggesting that vitamin C might play a valuable role in skincare regimens aimed at combating acne.

Overall, our study supports the idea that vitamin C, in the form of sodium L-ascorbyl-2-phosphate, can help reduce acne, making it a noteworthy addition to acne treatment strategies.

8.8

Reduces acne effectively

Most Useful Review

I trust and use Garden of Life's products due to their high quality. My son takes them with me, and he finds that his acne is less likely to occur. I also wish to continue using it for beauty and health.

Back Pain

Vitamin C's limited impact on pain

Based on 4 Researches

The Efficacy of Vitamin C on Postoperative Outcomes after Posterior Lumbar Interbody Fusion: A Randomized, Placebo-Controlled Trial.

Most Relevant Research

We conducted a year-long study to investigate the effects of vitamin C on postoperative pain and recovery after a specific type of spine surgery known as posterior lumbar interbody fusion (PLIF). In this randomized, placebo-controlled trial, we worked with 123 patients, dividing them into two groups: one receiving vitamin C and the other a placebo.

Our main focus was to see how vitamin C influenced lower back pain measured by a visual analogue scale. While we found that there was no significant difference in pain levels at the one-year mark between the two groups, there was a silver lining. We observed that vitamin C appeared to enhance functional improvement, especially within the first three months after surgery.

So, while vitamin C didn’t seem to directly reduce pain intensity after surgery, it could play a role in supporting early recovery and everyday function. This finding may encourage further exploration into vitamin C's potential benefits in postoperative care for patients undergoing spine surgeries.

8.8

Less back pain

Most Useful Review

I find this to be the most effective remedy. I take one capsule after breakfast and double it if I feel a cold coming on. My back pain has decreased and I feel much better.

Kidney Stones

Vitamin C intake risks explored

Total, Dietary, and Supplemental Vitamin C Intake and Risk of Incident Kidney Stones.

Most Relevant Research

We examined the relationship between vitamin C intake and the risk of developing kidney stones in a large cohort. This study included a significant number of participants: 156,735 women from the Nurses' Health Studies and 40,536 men from the Health Professionals Follow-up Study.

Our findings revealed that total and supplemental vitamin C intake was linked to a higher risk of kidney stones in men, but there was no such association evident in women. Specifically, among men, those who consumed higher amounts of vitamin C had greater likelihoods of developing stones when compared to those with lower intakes.

However, dietary vitamin C did not show a connection with kidney stones in either men or women. This suggests that while supplements may pose risks for men, dietary sources of vitamin C might not have the same impact. Overall, the study indicates that we should be cautious about high vitamin C supplement consumption, especially for men, while highlighting that dietary intake appears safe.

9.5

No kidney stones

Most Useful Review

Great, easily absorbable Vitamin C that doesn't cause kidney stones! I have metabolism issues and am unable to process many synthetic vitamins. This product is one of the few I can take without the risk of kidney stones or detox problems. Its dosage is higher than others, making it more affordable. A fantastic option for those needing a natural, absorbable Vitamin C.

Dizziness

Ascorbic Acid and Dizziness Study

Based on 3 Researches

Change of extracellular ascorbic acid in the brain cortex following ice water vestibular stimulation: an on-line electrochemical detection coupled with in vivo microdialysis sampling.

Most Relevant Research

We explored how ice water vestibular stimulation affects ascorbic acid (AA) levels in the brain, particularly in relation to dizziness. Using a method called in vivo microdialysis coupled with electrochemical detection, we monitored changes in extracellular AA in the primary somatosensory area of guinea pigs. Our study included 16 guinea pigs divided into three groups: one group received ice water stimulation, while the other two were exposed to warm water and ice water without vestibular input.

The results revealed that the concentration of extracellular AA increased in the brain following the ice water stimulation. This finding suggests that there may be neurochemical responses associated with AA that play a role in managing conditions like vertigo. However, while the study shows an intriguing relationship between AA levels and vestibular stimulation, it does not establish a direct link between vitamin C's effectiveness in treating dizziness specifically.

Overall, the insights gained from this research could help pave the way for further investigations into the role of vitamin C in vertigo-related treatments, adding a layer of understanding to its neurochemical functions.

9.5

No dizziness noted

Most Useful Review

Best vitamin product. Due to its natural ingredients, I don't experience dizziness even when taken on an empty stomach, and the components are excellent.

Pelvic Pain

I take 2 capsules a day for two months. The anti-inflammatory effect has been noticeable, as my low back pain has improved significantly.

Chest Pain

Vitamin C improves coronary response

Based on 13 Researches

Effect of ascorbic acid on endothelial dysfunction of epicardial coronary arteries in chronic smokers assessed by cold pressor testing.

Most Relevant Research

We explored the effects of vitamin C on chest pain in chronic smokers experiencing endothelial dysfunction. In our study, 31 patients, who were undergoing diagnostic catheterization without significant coronary artery issues, participated in a controlled trial. They were given either an IV infusion of 3 grams of ascorbic acid (vitamin C) or a placebo saline solution before undergoing a cold pressor test to assess their coronary artery response.

The results were telling. Smokers typically showed a decrease in luminal area—an indicator of blood flow—during the cold pressor test. However, after infusing vitamin C, this response shifted positively, demonstrating improved blood flow through a vasodilation effect. On the other hand, those who received the placebo did not experience significant changes.

This means that for chronic smokers, acute administration of vitamin C appears to enhance the function of the endothelium, which is vital for proper blood vessel health and managing chest pain. Ultimately, we observed that vitamin C may help prevent the inactivation of nitric oxide, a compound that supports healthy blood flow, and this effect could be crucial for managing cardiovascular health in smokers.

8.8

Pain improvement

Most Useful Review

I took 2 capsules daily for two months. It had quite an anti-inflammatory effect, as my low back pain has significantly improved.

Hives

Major allergic response

Be aware, this is not truly whole food C! Shortly after starting this "whole food vitamin C," I experienced hives, itching, and swelling—a full-blown histamine response. After investigating, I discovered that the ingredient labelled as Vitamin C was, in fact, yeast! Clearly, this isn't a reputable supplement.

Pancreatitis

Vitamin C alleviates pancreatic necrosis

High-Dose Vitamin C Alleviates Pancreatic Necrosis by Inhibiting Platelet Activation Through the CXCL12/CXCR4 Pathway in Severe Acute Pancreatitis.

Most Relevant Research

We explored whether high-dose vitamin C could help reduce pancreatic necrosis in cases of severe acute pancreatitis (SAP). Our observations reveal that platelet activation early in pancreatitis is a critical factor leading to pancreatic tissue death.

In our study, we examined the effects of high-dose vitamin C on pancreatic microcirculation in rats. We analyzed platelet activity in both SAP rats treated with vitamin C and those untreated. Additionally, we evaluated how vitamin C affects platelets from SAP patients.

To understand the mechanism at play, we used substances that could counteract vitamin C's effects, helping us pinpoint its role in platelet activation. The results indicated that vitamin C significantly improves blood flow and reduces pancreatic damage by inhibiting platelet activation, specifically through the CXCL12/CXCR4 pathway.

This research suggests that high-dose vitamin C could serve as a beneficial treatment for pancreatitis, potentially improving patient outcomes by tackling a major cause of pancreatic necrosis.

8.8

Good immune support

Most Useful Review

Miracle Vitamin This vitamin C is the only one that does not irritate my gastrointestinal tract. With my gastritis and pancreatitis, it's been challenging to find a suitable vitamin. This one is well-tolerated and absorbed easily. I take it twice daily, and it provides excellent support for my immune system.

Bloating

Vitamin C's impact on bloating

Associations Between Dietary Vitamin C, Serum Ascorbic Acid, and Genotype and Premenstrual Symptoms.

Most Relevant Research

We aimed to explore how different measures of vitamin C might influence premenstrual symptoms, particularly bloating. In this study, we analyzed data from 555 women aged 20 to 29 years who reported on various symptoms associated with their menstrual cycles. We looked at their dietary intake of vitamin C, measured serum ascorbic acid levels, and assessed genetic factors through DNA testing.

Our findings suggest that higher vitamin C status is linked to increased appetite changes and symptoms like bloating and swelling during the premenstrual phase. While we observed associations between vitamin C levels and these symptoms, it's important to note that our study didn't isolate the effect of vitamin C from other dietary influences. Therefore, while there's a connection between vitamin C and bloating, we cannot conclusively say that vitamin C alone is definitive in relief.

Overall, this research opens the door to understanding how nutrition, particularly vitamin C intake, may shape our experiences with premenstrual symptoms. However, it also highlights the complexity of diet's role in our health.

1.8

Causes discomfort

Most Useful Review

I did not like this product as it caused discomfort in my stomach, including bloating. Perhaps this is due to the yeast.

Heartburn

Vitamin C reduces heartburn symptoms

The safety and efficacy of 2% vitamin C solution spray for relief of mucosal irritation caused by Lugol chromoendoscopy: a multicenter, randomized, double-blind, parallel trial.

Most Relevant Research

We investigated how vitamin C, specifically in the form of a 2% vitamin C solution spray, could help alleviate heartburn symptoms following Lugol chromoendoscopy, a procedure that involves staining the esophagus to better visualize abnormalities. In a well-structured study with 240 participants, we used a randomized, double-blind approach to compare the effectiveness of vitamin C to normal saline and sodium thiosulfate solutions.

Our results showed that vitamin C spray significantly reduced both acute heartburn symptoms and late discomfort when compared to the saline solution. Specifically, 33% of participants using vitamin C reported relief from acid regurgitation or heartburn, compared to just 15% with sodium thiosulfate. Additionally, patients noted an improvement in retrosternal pain, with 21% finding relief from the vitamin C treatment versus 9% from sodium thiosulfate.

Furthermore, vitamin C offered a quicker discoloration of the iodine-stained mucosa compared to saline, enhancing the overall experience of the procedure. These findings suggest that incorporating vitamin C spray into post-procedural care could be a helpful strategy for patients facing discomfort after undergoing Lugol chromoendoscopy.

9.5

No heartburn

Most Useful Review

Excellent medium capsules, which are easy to swallow—even when fasting. I take two capsules daily, and I haven't experienced any heartburn. I really like this manufacturer's vitamins; they are excellent quality, and I recommend them!

Headache

Vitamin C intake reduces migraines

Association between dietary vitamin C intake and migraine in adults: A cross-sectional study of the National Health and Nutrition Examination Survey.

Most Relevant Research

We aimed to understand how dietary vitamin C affects migraines by analyzing data from the National Health and Nutrition Examination Survey, conducted from 1999 to 2004. In this survey, we identified adults who reported experiencing severe headaches or migraines over the past three months.

Our findings were quite revealing. Out of 4,101 participants, 702 individuals reported having a migraine, which represents about 17% of the group. We discovered an interesting trend: higher dietary vitamin C intake seemed to correlate with a lower likelihood of experiencing migraines. Specifically, participants with the highest vitamin C intake had a 36% reduced odds of suffering from migraines compared to those with the lowest intake.

We employed various statistical methods to confirm our results, including logistic regression and restricted cubic spline regression, which showed a clear linear relationship between vitamin C intake and the frequency of migraines.

Overall, this study suggests that increasing our dietary vitamin C might help minimize migraines, which is promising news for those who suffer from these intense headaches. However, as with all studies, further research is necessary to solidify these findings and fully understand the relationship between vitamin C and headache relief.

Headaches resolved

Most Useful Review

I was convinced of vitamin C's effectiveness. At the first signs of symptoms, I took 1 capsule every 2 hours, and by evening, my headaches and other symptoms had vanished.

Heart Disease