Jarrow Formulas Extra Strength Methyl B-12 1000 mcg

Vitamin B12 ineffective for CFS

N of 1 trials. Managing patients with chronic fatigue syndrome: two case reports.

Most Relevant Research

We explored the effectiveness of high-dose vitamin B12 injections on chronic fatigue syndrome (CFS) through two case reports that utilized N of 1 trials. This approach allowed us to make tailored treatment decisions based on individual responses to the therapy.

In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.

These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.

9.5

Reduced fatigue

Most Useful Review

Good vitamins; as recommended by my doctor for the nervous system and reducing fatigue, they accomplished just that. I highly recommend purchasing them.

Frozen Shoulder

Effective for headaches

Wonderful effect! The product stabilises my spirit and significantly alleviates shoulder stiffness and muscle fatigue. I found it particularly effective for tired eyes and headaches resulting from eye strain. The strength of this effect, especially at this price, is remarkable!

Blood Clot

Vitamin B12's role in clotting

Based on 8 Researches

Nitrous Oxide-Induced Cerebral Venous Thrombosis: A Case Report, Potential Mechanisms, and Literature Review.

Most Relevant Research

We observed a compelling case involving a 19-year-old female diagnosed with cerebral venous thrombosis (CVT) and intracerebral hemorrhage. This unusual situation stemmed from her history of nitrous oxide abuse, which led to a significant deficiency in vitamin B12. Nitrous oxide can interfere with vitamin B12's vital functions, particularly its role in breaking down homocysteine levels in the blood.

Our investigation revealed her serum vitamin B12 level was alarmingly low at less than 100 pg/mL, while her homocysteine levels soared to 100.6 µmol/L, far exceeding the normal range. After she began vitamin B12 supplementation, we were pleased to see her vitamin B12 levels return to normal, along with a drastic reduction in homocysteine.

This case highlights an essential connection: low vitamin B12 levels may contribute to hyperhomocysteinemia, which in turn could play a significant role in the formation of blood clots. While there were no other thrombophilia risk factors found, the evidence suggests that restoring vitamin B12 levels through supplementation can positively impact homocysteine levels and reduce the risk of clotting problems.

Overall, this finding underscores how important vitamin B12 is in maintaining healthy blood clotting mechanisms.

9.5

Reduced homocysteine levels

Most Useful Review

Vitamin B12 effectively reduces homocysteine, vital for cardiovascular health. My husband’s blood tests revealed his homocysteine levels decreased from 12 to 8 μmol/l after using this product, which indicates an impressive improvement. It's especially important for managing blood clot risks as we age. We intend to use it regularly.

Bone Pain

I take Vitamin B12 for red blood cell formation and nerve health due to a deficiency shown in my analysis. This vitamin is necessary as its absence can cause fatigue, bone pain, and memory issues. The methylcobalamin form is effectively absorbed by the body.

Cardiovascular Disease

Vitamin B12 reduces cardiovascular risks

Based on 2 Researches

Association of MTHFR C677T, MTHFRA1298C, and MTRRA66G Gene Polymorphisms with Hyperhomocysteinemia and Its Modulation by the Combined Effect of Vitamin B12 and Folate in Chinese Population with Hypertension.

Most Relevant Research

We explored the connection between vitamin B12, genetic factors, and cardiovascular health in a group of Chinese adults suffering from hypertension. By analyzing the genetic variations of individuals, we aimed to understand how these may influence levels of homocysteine, an amino acid that can impact heart health when present in high amounts.

Our study included 1,304 participants over the age of 18. We measured their serum levels of vitamin B12 and folate, as well as their total homocysteine concentrations. The findings were quite significant: adequate levels of both vitamin B12 and folate were linked to lower homocysteine levels. This suggests that ensuring proper nutrition might be key to managing cardiovascular risks associated with high homocysteine.

We also noticed that the genotypic effects on homocysteine levels could be lessened with sufficient intake of these vitamins. Targeted nutritional interventions, such as increasing vitamin B12 and folate in the diet, could therefore play an essential role in heart health for those at risk. Our results emphasize the importance of nutrition in supporting cardiovascular health and managing hypertension.

9.5

Eased symptoms effectively

Most Useful Review

This product has alleviated my severe folic acid and B12 deficiency symptoms, such as numbness and muscle pain. Unlike injections, these easy-to-take pills have shown remarkable results. I feel energised, and the sweet taste makes it enjoyable. I highly recommend it for overall well-being.

Common Cold

Strengthened immunity

Great supplement! My doctor, a neurologist, prescribed this to support my nervous system, especially as I was experiencing bothersome tinnitus. The tablets are small and have a slightly sweet lemon flavour. I was pleased with its effectiveness; I did not catch a common cold this autumn, and my immunity felt stronger. My joint mobility improved, sleep was better, and it helped stabilise my overall psychological state. Excellent dietary supplement at a budget-friendly price!

Depression

Vitamin B12 shows no benefit for depression

Based on 11 Researches

Assessment of Vitamin B12 Efficacy on Cognitive Memory Function and Depressive Symptoms: A Systematic Review and Meta-Analysis.

Most Relevant Research

We assessed the effect of vitamin B12 supplementation on depressive symptoms by reviewing several randomized controlled trials (RCTs). Our analysis focused on participants who may experience mild cognitive impairment, an area where low vitamin B12 levels could potentially raise the risk of depression.

After a thorough examination of studies, we found that the included trials did not support a significant benefit of vitamin B12 for alleviating depressive symptoms. In our evaluation of three studies focusing specifically on depression, the average difference in symptoms was negligible, indicating no real effect.

This outcome reflects that while vitamin B12 is essential for various bodily functions, its role in improving mood and reducing depression symptoms may not be as effective as some might hope. Further exploration is still warranted to better understand the contexts in which vitamin B12 could be beneficial.

9.5

Supports emotional stability

Most Useful Review

Methylcobalamin has shown effects for me! As a nerve vitamin, it assists in nerve repair and regeneration. I discovered it helps with my moods, particularly with depression. I believe it can benefit empaths and those sensitive to their surroundings when paired with vitamin C.

Irritable Bowel Syndrome

Dietary guidance aids IBS management

Effects of dietary guidance on the symptoms, quality of life and habitual dietary intake of patients with irritable bowel syndrome.

Most Relevant Research

We examined how dietary guidance affects irritable bowel syndrome (IBS) symptoms and quality of life, particularly focusing on vitamin B12 intake. Our study involved 46 patients diagnosed with IBS based on established criteria, with 17 completing the entire program.

Through three sessions of personalized dietary advice, each lasting about 45 minutes, we found a significant reduction in IBS symptoms after the patients implemented the dietary changes. Their quality of life scores also improved notably. Although we noted an increase in vitamin B12 intake, it's important to emphasize that we did not isolate its effects from those of other dietary changes.

Interestingly, while our guidance helped patients enhance their overall nutrient intake, including vitamins and minerals, the increase in vitamin B12 specifically was the only change that reached statistical significance. However, we found no substantial differences in overall caloric or macronutrient intake among the participants.

In conclusion, while dietary guidance showed promising benefits for managing IBS symptoms and overall life quality, the impact of vitamin B12 alone remains unclear, as other dietary modifications may have played a role. Our findings suggest that individualized dietary counseling is a viable option in IBS management.

9.5

Improved gut health

Most Useful Review

Leaky Gut syndrome led to a deficiency in vitamin B12. While overcoming this condition, my teacher Cairo recommended a lozenge form for better absorption. Since the absorption was poor due to my weak stomach mucosa, I take it twice a day, enjoying its lemon flavour. My sleep improved, and I feel my leaky gut symptoms have almost disappeared after six months. This affordable option has been effective for me.

Anxiety

Vitamin B12 may reduce anxiety

Based on 4 Researches

Therapeutic intervention of vitamin B12 in mitigating chronic alcoholism induced alterations in adult zebrafish (): a holistic approach.

Most Relevant Research

We investigated the potential of vitamin B12 to mitigate anxiety in adult zebrafish subjected to chronic alcohol exposure. Our study involved exposing zebrafish to alcohol and then providing them with vitamin B12 to see if it would help reduce anxiety-related behaviors. By using a geotaxis test, we could observe how the fish responded in terms of anxiety in a controlled environment.

The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.

Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.

8.8

Improved sleep quality

Most Useful Review

After being a raw foodist and vegan for three years, my B12 levels were critically low at 99 units. I started taking a bioavailable B12 supplement, and after a month, my levels rose to nearly 600 units. I noticed a significant improvement in my sleep and a reduction in my anxiety. I highly recommend this.

Back Pain

Vitamin B12 aids low back pain

Based on 16 Researches

Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study.

Most Relevant Research

We conducted a thorough investigation to understand whether intramuscular vitamin B12 treatment could effectively relieve low back pain. This study was designed as a double-blind, placebo-controlled trial involving 60 patients aged 18 to 65 who suffered from mechanical low back pain or sciatic neuritis. Each participant had a history of back pain lasting from six months to five years and reported significant pain intensity according to a standard scale.

By comparing two groups—the one receiving vitamin B12 injections and the other receiving a placebo—we focused on measuring changes in pain and disability levels, as well as any changes in paracetamol consumption. What we found was quite impressive. Both groups reported decreases in pain and disability. However, those who received vitamin B12 showed significantly better results compared to the placebo group. The difference was not only notable in terms of pain relief but also in lower dependency on paracetamol for pain management.

Our findings confirm that vitamin B12 can be a safe and effective option for patients with low back pain, particularly for those who don't have any signs of nutritional deficiency. The data suggest that patients experiencing this common ailment could consider discussing vitamin B12 treatment with their healthcare provider as part of their pain management strategy.

9.5

Reduced foot pain

Most Useful Review

I initially tried B12 for Morton's neuroma, and it worked wonders. I've noticed a significant reduction in foot pain and regained feeling in areas that had been numb for quite some time, highlighting the importance of B12.

Bruise

Vitamin B12 benefits thrombocytopenia

Vitamin B12 Deficiency, a Rare Cause of Isolated Thrombocytopenia in Adults.

Most Relevant Research

We examined the case of a 38-year-old male who experienced bruising and fatigue due to isolated thrombocytopenia, a condition marked by a low platelet count. This situation was particularly interesting because the underlying cause turned out to be a significant deficiency in vitamin B12, which is quite rare in adults when it comes to isolated thrombocytopenia. As we explored the case, we found that the patient's vitamin B12 levels were extraordinarily low, prompting treatment with subcutaneous mecobalamin, a form of vitamin B12.

After several doses, not only did the vitamin B12 levels increase, but so did the platelet count, contributing to the resolution of the bruising issue. This highlights the role that vitamin B12 can play in improving hematological health, specifically in cases of thrombocytopenia. Although the lack of hypersegmented neutrophils usually linked to vitamin B12 deficiency was noted, it emphasized the complex nature of diagnosing such conditions and the need for careful evaluation of symptoms and lab results.

9.5

Restored ferritin levels

Most Useful Review

My gynecologist prescribed B-12 due to dysbacteriosis and low ferritin, which caused fatigue and bruising under my eyes. This supplement helped raise my ferritin levels and alleviated all related symptoms. I chew the tablets as they take time to dissolve, and I find them quite pleasant to taste.

Heart Attack

Vitamin B12 shows no heart attack benefit

Likely Ineffective

Based on 2 Researches

Urinary excretion of homocysteine thiolactone and the risk of acute myocardial infarction in coronary artery disease patients: the WENBIT trial.

Most Relevant Research

In a recent study, we delved into the role of homocysteine thiolactone, a metabolite linked to heart disease, in predicting the risk of acute myocardial infarction (AMI). Conducted with a sizable group of 2049 patients suspected of having coronary artery disease (CAD), the trial was meticulously designed as a double-blind clinical intervention.

Participants were divided randomly into four distinct groups, receiving a combination of folic acid and other B vitamins or a placebo. Notably, we measured urinary levels of homocysteine thiolactone at different points throughout the study to draw correlations with heart attack incidents.

Our analysis revealed that while the homocysteine thiolactone/creatinine ratio was a significant predictor of AMI risk, there was no observable effect from the vitamin B treatments received by participants. This suggests that vitamin B12, when part of a group of B vitamins, did not independently influence the likelihood of having a heart attack.

Ultimately, we found that higher levels of homocysteine thiolactone correlated with a greater risk of AMI, but the combination of vitamin B treatments did not alter this outcome. This points to the potential of homocysteine thiolactone as an important marker in understanding cardiovascular health.

8.8

Enhances cardiovascular health

Most Useful Review

This supplement is beneficial for the nervous system and supports the brain and spinal cord. It helps the cardiovascular system by preventing thrombus formation, reducing the risk of atherosclerosis, heart attack, and stroke, while also normalising blood pressure.

Hypothyroidism

Vitamin B12 and hypothyroid patients

Likely Ineffective

Based on 4 Researches

A Study on Vitamin B12 Levels in Hypothyroid Patients Presenting to a Tertiary Care Teaching Hospital.

Most Relevant Research

We explored the connection between vitamin B12 deficiency and hypothyroidism through a focused study involving 100 hypothyroid patients. This research took place over a year and aimed to determine how common vitamin B12 deficiency is among these individuals and how it correlates with thyroid antibodies.

Our findings revealed that a significant 68% of the hypothyroid patients were vitamin B12 deficient. Interestingly, a large majority of these deficient patients were female, specifically 73.5%. Additionally, we noted that a high percentage of patients with elevated Anti TPO and Anti Thyroglobulin antibodies also had low vitamin B12 levels.

Although vitamin B12 deficiency was present in a notable portion of the hypothyroid population, we're careful to point out that the study does not state that vitamin B12 supplementation alone can fully alleviate hypothyroid symptoms. However, it suggests that addressing this deficiency could be a valuable addition to current hypothyroid treatments. By recognizing and treating vitamin B12 deficiency, we may improve the overall management of hypothyroid conditions for some patients.

8.8

Enhanced mood

Most Useful Review

Remarkable for mood and energy, but be cautious of breakouts! I’ve tried numerous supplements and nothing has affected me this positively and quickly. This sublingual B12 has significantly improved my mood swings, energy, and concentration. I’m pleased to have tried it for my anaemia related to hypothyroidism. However, I may need to reduce the dosage due to hairline and back acne reactions caused by high B12 levels.

Leg Cramps

I started taking this after my left leg went numb. After a month, the numbness disappeared, and my blood test showed improved MCV levels, so it seems to be effective.

Menopause

Vitamin B12 may aid menopause relief

Likely Very Effective

Based on 2 Researches

Improvement in menopausal symptoms with a nutritional product containing evening primrose oil, hop extract, saffron, tryptophan, vitamins B6, D3, K2, B12, and B9.

Most Relevant Research

We observed the effects of a nutritional product that combined various ingredients, including vitamin B12, on menopausal symptoms. This study involved 156 menopausal women who took the product daily for 12 weeks and reported their symptoms using a validated scale.

After completing the study, we found significant reductions in various menopause-related issues. This included a substantial 45% decrease in depressive mood and a notable reduction of 48% in hot flashes. It's important to note that while vitamin B12 was included in the treatment, it was part of a broader combination with other beneficial ingredients.

However, we must clarify that the specific impact of vitamin B12 alone cannot be fully determined from this study. The results are promising for the product as a whole, showing effective relief from many menopausal symptoms, but further research is needed to isolate the role of vitamin B12 in managing these symptoms.

9.5

Better sleep

Most Useful Review

Great product. I sleep better after taking it. It helps stabilise my autonomic nervous system during menopause. The quality is very good and the price is reasonable.

Migraine

Vitamin B12 deficiency and migraines

Based on 11 Researches

The correlation between vitamin B12 serum levels and migraine: a case-control study.

Most Relevant Research

We examined the connection between vitamin B12 serum levels and migraine, both chronic and episodic. In our study, we compared two groups: 90 individuals suffering from migraines and 90 healthy participants. We measured the serum vitamin B12 levels of all subjects using a method known as enzyme-linked immunosorbent assay (ELISA).

Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.

This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.

8.8

Effective for migraines

Most Useful Review

It works well! I find this vitamin B12 beneficial for my migraines, especially considering its easy-to-take ramune form. Traditional tablet types are difficult for me to swallow. This supplement helps refresh my mind and eases neck stiffness, which contributes to my tinnitus. I particularly recommend it for anyone suffering from light sensitivity associated with migraines.

Pelvic Pain

I was concerned about pain in my right elbow and was informed that methylcobalamin is effective for joint pain and numbness, so I purchased it. After reading reviews about its good absorption when melted under the tongue, I tried it. My elbow pain has since vanished, so I now take it regularly.

Shingles

Vitamin B12 aids shingles pain relief

Vitamin B12 for herpetic neuralgia: A meta-analysis of randomised controlled trials.

Most Relevant Research

We conducted a review of randomized controlled trials to determine the effectiveness of vitamin B12 in treating postherpetic neuralgia (PHN), a painful condition following shingles. Our analysis included data from databases such as PubMed and Cochrane Library, focusing specifically on trials that measured pain relief outcomes.

Our findings indicate that vitamin B12 supplementation has a significant positive effect on reducing pain levels in PHN patients. In fact, those who received vitamin B12 experienced a notable decrease in pain compared to those on placebo, with a reduction in the pain score of about four points. This result suggests that vitamin B12 not only helps with pain relief but also enhances overall quality of life for individuals suffering from this distressing condition.

Additionally, we observed a drop in the number of patients relying on analgesics, pointing to a potential alternative treatment avenue with vitamin B12. Although the evidence is moderate in quality, it presents a compelling case for the use of vitamin B12 as a complementary therapy for managing pain associated with shingles.

9.5

Pain relief

Most Useful Review

I have been using this product for years, learning that cobalamin is vital for recovery from illness. When I developed shingles, I increased my intake and saw the growth of new shingles stop, with healing occurring without blistering. The pain subsided after taking one tablet daily, so I didn't need to go to the hospital; this product is fantastic!

Stroke

Vitamin B12 alleviates stroke effects

Based on 12 Researches

Functional regulation of microglia by vitamin B12 alleviates ischemic stroke-induced neuroinflammation in mice.

Most Relevant Research

We investigated how vitamin B12 impacts neuroinflammation and recovery after an ischemic stroke. Our findings revealed that vitamin B12 plays a crucial role in programming microglial cells—immune cells in the brain—helping them divide and activate effectively, which is vital during the healing process. This treatment appeared to improve the metabolism of these cells as well, promoting better functionality and reduced brain injury after a stroke.

Interestingly, we found that vitamin B12 significantly limited gene alterations associated with strokes in these microglia. Throughout the acute phase of an ischemic stroke, vitamin B12 altered the activities of different microglial subsets, leading to less brain damage and enhanced neurological recovery for the mice in our study. However, when we depleted microglia before administering the stroke, the beneficial effects of vitamin B12 disappeared, highlighting the importance of microglia in this process.

Overall, our research underscores the potential of vitamin B12 in mitigating neuroinflammation and aiding recovery for stroke victims. Through our preclinical studies, we've established that vitamin B12 may indeed offer a promising avenue for improving neurological outcomes post-stroke, meriting further exploration.

8.8

Reduces stroke risk

Most Useful Review

This complex is truly wonderful, containing essential B vitamins (B12, B6, B9) in their active forms. They assist with chronic viral loads and lower homocysteine levels, consequently reducing the risk of cardiovascular diseases, particularly stroke. This complex is vital for the elderly who are at risk.

Cancer

Vitamin B12 and lymphoma association

Based on 6 Researches

Circulating levels of vitamins and risk of lymphoma: insights from a two-sample Mendelian randomization.

Most Relevant Research

We aimed to understand how levels of vitamin B12 might influence the risk of developing lymphoma, a type of cancer that affects the lymphatic system. Using data from comprehensive genome-wide association studies, we assessed the potential genetic links between circulating vitamin levels and lymphoma.

Our analysis particularly focused on vitamin B12 along with other vitamins, utilizing robust methods to ensure reliable results. We discovered that higher levels of vitamin B12 showed a noticeable association with a lower risk of lymphoma, indicating that it might play a beneficial role in cancer prevention. Interestingly, we also found similar results for folic acid, suggesting that these vitamins could have important implications for lymphoma risk overall.

However, it's essential to note that while our findings are promising, the evidence isn't definitive. Further research is needed to explore these relationships in greater depth and to understand the mechanisms behind them. Understanding how vitamins like B12 affect cancer could lead to better preventive strategies in the future.

Helpful for neuropathy

Most Useful Review

Great products that have been very beneficial for neuropathy resulting from cancer treatments.

Gastritis

Vitamin B12 aids autoimmune gastritis

Based on 3 Researches

Autoimmune gastritis as an unexpected cause of diarrhea in a young adult with type I diabetes: a case report.

Most Relevant Research

We observed a case involving a 20-year-old woman with Type 1 diabetes experiencing persistent gastrointestinal issues, including diarrhea and nausea. Her medical journey led her to be diagnosed with autoimmune gastritis, an uncommon but important condition.

In the course of her treatment, we noticed her Vitamin B12 levels were not deficient, which is traditionally expected with autoimmune gastritis. Despite this, she was given parenteral Vitamin B12 therapy due to her neurological symptoms.

This case highlights that even when Vitamin B12 deficiency isn’t present, administration of Vitamin B12 can still provide significant relief from symptoms related to autoimmune gastritis. We learned that prompt treatment can prevent further neurological damage and improve overall quality of life for patients with autoimmune conditions.

8.8

Heart palpitations alleviated

Most Useful Review

I was suffering from gastritis, which led to a B12 deficiency and heart palpitations. Initially, I took one tablet but saw no improvement, so I increased the dosage to two or three. I’m pleased to say that I’m now feeling fine.

Hashimoto

Vitamin B12 aids Hashimoto's recovery

Based on 3 Researches

Energetic homeostasis achieved through biophoton energy and accompanying medication treatment resulted in sustained levels of Thyroiditis-Hashimoto's, iron, vitamin D & vitamin B12.

Most Relevant Research

We explored the effect of vitamin B12 treatment on a 37-year-old woman suffering from Hashimoto's Thyroiditis. Her journey started with symptoms like fatigue, weakness, and muscle pain, all exacerbated by underlying conditions such as iron deficiency anemia, and deficiencies in vitamin D and B12.

Upon further investigation, we discovered that her low vitamin levels were linked to Celiac disease, which was affecting her overall health. As part of her treatment plan, she began taking daily medications while also being exposed to biophoton energy from a specialized device. This combination aimed not only to replenish her vitamin levels but also to improve her entire body’s functionality.

Notably, her health significantly improved with this dual approach. The biophoton exposure helped stabilize her blood components and enhanced the conditions of her organs and systems. Although we cannot definitively isolate the impact of vitamin B12 alone, it appears that, along with other treatments, it played a vital role in her recovery.

In summary, while vitamin B12 seems to contribute positively to managing Hashimoto's Thyroiditis, its effectiveness cannot be fully measured in isolation due to the combination with other therapies in her treatment plan.

8.8

Improved clarity

Most Useful Review

Great choice! I recommend it to everyone! It's the perfect combination of price and quality. With my hypothyroidism and Hashimoto's, vitamin B12 is essential for me. After taking it for a month, I noticed improvements on the first day: my hands warmed up, my mind felt clearer, and my anxiety reduced. I take one tablet before bed, sometimes in the morning before a demanding day.

Liver Disease

Methylcobalamin aids liver health

Based on 10 Researches

Methylcobalamin protects against liver failure via engaging gasdermin E.

Most Relevant Research

We explored how methylcobalamin, a form of vitamin B12, impacts liver disease, particularly in the context of cholestatic liver failure. The study utilized high-throughput screening to identify methylcobalamin as a specific inhibitor of gasdermin E (GSDME), a protein that plays a key role in pyroptotic cell death—a form of inflammatory cell death contributing to liver damage.

Our findings showed that when tested on mouse models with liver failure due to cholestasis, cisplatin, or concanavalin A, methylcobalamin effectively reduced liver damage. It significantly lowered liver transaminase levels, indicating less liver inflammation and cellular injury, and helped alleviate overall liver cell death.

Furthermore, methylcobalamin worked by preventing the cleavage of GSDME, which is essential for uncontrolled inflammatory cell death. By binding to a specific site on the GSDME protein, it blocked the interactions that trigger this damaging process. Overall, our study highlighted the potential of methylcobalamin as a promising therapeutic option for managing cholestatic liver failure and related conditions.

8.3

Memory improvement

Most Useful Review

B12 greatly influences memory. After experiencing memory decline at 70, I had a blood test to check my B12 levels. I started chewing one tablet daily, and I’ve noticed significant improvement in my memory. My family also takes it, and it's genuinely helpful for maintaining cognitive function, especially concerning liver disease.

Reflux

Nice! It tastes alright and seems strong enough while dissolving well without aggravating my reflux. I took this to help elevate my blood platelets, an issue from chemotherapy. I'm impressed with the quality, especially for the price.

Tendonitis

Vitamin B12 aids tendon healing

Blocking proteinase-activated receptor 2 signaling relieves pain, suppresses nerve sprouting, improves tissue repair, and enhances analgesic effect of B vitamins in rats with Achilles tendon injury.

Most Relevant Research

We explored the effects of the vitamin B complex, particularly focusing on vitamin B12, in treating pain and promoting recovery from Achilles tendon injuries. The study showed that tendon injury leads to significant pain and nerve changes, largely due to the activation of proteinase-activated receptor 2 (PAR2). By blocking this receptor, we observed a noteworthy decrease in pain and nerve sprouting, alongside improved structural healing of the tendon.

Vitamin B complex, which includes B12, played a key role by suppressing PAR2 activation. This suppression resulted in reduced pain and offered a boost to the healing process in the affected tendons. The findings suggest that vitamin B12, when used in combination with other vitamins, could indeed provide relief for tendonitis-related pain and help support tissue repair.

Overall, these insights into vitamin B12 and its beneficial effects signal a promising direction for future treatments of tendon injuries. It highlights the potential of integrating such vitamins into pain management strategies for tendon injuries, which often pose significant challenges.

8.8

Significant improvement

Most Useful Review

After injuring my fingers and experiencing tendonitis in both hands, I saw no improvement for a month. However, once I began drinking it, my condition improved within days. While this could be a coincidence, the cessation of my tendonitis symptoms leads me to believe it has been effective.

Ulcer

Genetic insights into ulcer healing

Based on 5 Researches

Phenotype puzzle: the role of novel LMBRD1 gene variant in Cbl deficiency causing Dyskeratosis Congenita-like clinical manifestations.

Most Relevant Research

We delved into the complexities surrounding a specific genetic mutation in the LMBRD1 gene, which is linked to a variant form of cobalamin (vitamin B12) deficiency. This study highlighted a 15-year-old male with symptoms typical of Dyskeratosis Congenita, including skin hyperpigmentation and ulcers. After identifying a novel splice site deletion in the gene, we learned that this alteration can heavily impact vitamin B12 metabolism and lead to various clinical manifestations, including ulcers.

Importantly, we observed the effects of administering intravenous hydroxocobalamin therapy. Following treatment, our findings indicated a notable improvement in the patient's skin hyperpigmentation, angular cheilitis, and the painful aphthous ulcers. While the study primarily focused on genetic factors and treatment responses, the results suggested that vitamin B12 therapy plays a valuable role in alleviating ulcer symptoms. We encourage further exploration to expand our understanding of these relationships and optimize treatment approaches.

9.5

Effective treatment

Most Useful Review

B12 has been beneficial for my mouth ulcers.

Yeast Infection

Effective for comfort

This product is excellent! I’ve used it for years and prefer it to a B12 shot I received from the doctor, which didn’t help and led to a yeast infection. This product not only resolves that issue but also tastes so good that I have to limit myself like it’s candy. It calms my nerves and makes me feel significantly better instantly. Highly recommended!!!

Alzheimer

Vitamin B12's limited effect on Alzheimer's

Role of vitamin B12 and folic acid in treatment of Alzheimer's disease: a meta-analysis of randomized control trials.

Most Relevant Research

We explored the potential role of vitamin B12, alongside folic acid, in slowing the progression of Alzheimer's disease (AD) through a meta-analysis of randomized control trials. Our aim was to determine whether these supplements might improve cognitive function, daily life activities, and influence blood homocysteine levels in individuals diagnosed with AD.

After carefully sifting through studies, we found five that met our criteria. These studies assessed the cognitive changes in participants through the Mini-Mental State Examination (MMSE) and the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog). Additionally, they examined the impact on daily functioning as well as blood homocysteine levels.

The results showed that after six months of treatment, participants taking vitamin B12 and folic acid did experience a slight improvement in MMSE scores compared to those on a placebo. However, there was no significant change in the ADAS-Cog scores, which means some cognitive aspects didn’t show marked improvement. Likewise, daily life functioning did not see any benefits from the supplements.

Importantly, we also noted a significant reduction in blood homocysteine levels following the supplementation, suggesting a biochemical effect of the treatment. Overall, while vitamin B12 shows promise in enhancing some cognitive measures, it does not translate directly into broader cognitive or daily functioning improvements in Alzheimer's patients.

8.8

Neuroprotective effects

Most Useful Review

Unlike cyanocobalamin, methylcobalamin is a naturally occurring form of vitamin B12, better absorbed in our bodies. It supports lipid production and nerve regeneration, making it beneficial for Alzheimer's. A starting dose of 1000mcg is safe, as excess amounts are excreted. The small, sweet tablets should be held in the mouth until they dissolve. The price is reasonable.

Anemia

Vitamin B12 effectively treats anemia

Based on 11 Researches

An Unusual Case of Hemolytic Anemia: A Case Report.

Most Relevant Research

We observed a compelling case surrounding the impact of vitamin B12 on anemia, particularly in a 62-year-old man facing severe deficiencies due to factors like drug use, hepatitis C, smoking, and alcoholism. Initially, this patient presented with symptoms such as fatigue, fever, and confusion, raising concerns about more critical conditions like thrombotic thrombocytopenic purpura (TTP). Laboratory tests indicated severe pancytopenia and signs of hemolysis, making the situation quite alarming.

However, further investigation revealed that the root cause was a significant deficiency of vitamin B12 coupled with folate. This discovery shifted our focus toward treatment strategies that addressed the underlying deficiency rather than applying unnecessary and invasive procedures like plasmapheresis. Upon administering vitamin B12 injections, we witnessed a refreshing turnaround as the patient's blood counts began to normalize progressively, along with an alleviation of symptoms.

This case emphasizes the necessity for healthcare providers to consider vitamin B12 deficiency when diagnosing patients presenting with hemolytic anemia and thrombocytopenia. By doing so, unnecessary treatments can be avoided, paving the way for a swift recovery through proper vitamin supplementation.

9.5

Eliminated injections

Most Useful Review

I'm unsure why others find these lozenges slow to dissolve; they are meant to melt gradually. With pernicious anaemia, I can't absorb B12 in my stomach, so I keep the lozenge between my gum and lip for absorption through the mouth. After using one daily, I no longer require injectable B12.

Brain Tumor

Likely Ineffective

Vitamin B12's unclear impact on glioblastoma

Effect of pyridoxine or cobalamin supplementation on apoptosis and cell cycle progression in a human glioblastoma cell line.

Most Relevant Research

We explored the effects of vitamin B12 (cobalamin) supplementation on a human glioblastoma cell line known as U-87 MG. Our main goal was to understand how cobalamin, particularly in combination with pyridoxine (vitamin B6), influences cell viability and the process of cell death, known as apoptosis.

Our approach involved treating the glioblastoma cells with varying concentrations of vitamin B12 over a period of 24 to 72 hours. We assessed the health of the cells and their progression through the cell cycle using methods like spectrophotometry and flow cytometry. We also measured specific proteins associated with cell survival and death through western blot analysis.

We found that while vitamin B6 supplementation led to decreased cell viability and increased signs of apoptosis, the role of vitamin B12 was less clear. It appeared that cobalamin did not significantly enhance or inhibit cell death on its own. However, when combined with pyridoxine, it seemed to reduce the cytotoxic effects of vitamin B6.

In summary, while vitamin B12 in isolation did not show a direct benefit for the glioblastoma cells in our study, its potential to influence the effects of other vitamins highlights a complex interaction deserving of further exploration.

7.5

Improved energy levels

Most Useful Review

After maintaining a strict raw and vegan diet for three years, my B12 levels were alarmingly low. However, after a month of taking bioavailable B12 supplements, my levels rose to nearly 600 units, normalising my condition. This not only enhanced my sleep but also reduced my anxiety. I noticed increased calmness and energy, particularly when I began exercising regularly, which is crucial in managing my brain tumour.

Dizziness

Vitamin B12 improves dizziness symptoms

Based on 10 Researches

Acute presentation of dizziness in vitamin B12 deficient old patient of cardiac disease: a case report.

Most Relevant Research

We observed a fascinating case involving an elderly patient who experienced acute dizziness, ataxia, and imbalance shortly after receiving a pacemaker. Upon investigation, we discovered that her symptoms were linked to a significant deficiency in vitamin B12.

The patient's vitamin B12 levels were notably low, accompanied by increased plasma homocysteine and methylmalonic acid levels. Despite her neurological symptoms suggesting peripheral neuropathy, her brain scan returned normal results. What stood out to us was the absence of the typical hematological signs often associated with vitamin B12 deficiency.

Importantly, the patient responded remarkably well to treatment with parenteral vitamin B12, leading to a resolution of her dizziness. This case underscores the importance of considering vitamin B12 deficiency, especially in elderly patients who present with neuropsychiatric symptoms. As we reflected on this, it became clear that proper recognition and treatment of vitamin B12 deficiency can significantly influence patient outcomes.

9.5

Improved dizziness relief

Most Useful Review

This Vitamin B12 is effective! It helps with dizziness and other ailments like neck pain. The ramune type is easier to take than large tablets, making it enjoyable to continue using. I feel more refreshed, and it alleviates my tinnitus related to neck stiffness. I’d love to see more B vitamins in this form!

Heart Disease

Vitamin B12 helps heart recovery

Based on 4 Researches

Vitamin B12 alleviates myocardial ischemia/reperfusion injury via the SIRT3/AMPK signaling pathway.

Most Relevant Research

We explored how vitamin B12 can act as a safeguard against heart damage caused by ischemia/reperfusion (I/R) injury. In our study, we used a mouse model subjected to I/R injury by occluding the left anterior descending coronary artery, followed by 24 hours of reperfusion.

Our aim was to see if high doses of vitamin B12 could improve heart function and reduce damage. Through various evaluations, including echocardiography and biochemical methods, we revealed that vitamin B12 supplementation does indeed help. It mitigates oxidative stress and lowers levels of harmful reactive oxygen species.

Additionally, we found that B12 supplementation reduced cell apoptosis—essentially cell death—in heart tissues. This response was linked to the action of specific signaling pathways, particularly the SIRT3/AMPK pathway. However, we noted that these protective effects diminished when a SIRT3 inhibitor was introduced, indicating the importance of this pathway.

Moreover, RNA sequencing data showed that vitamin B12 also plays a role in reducing inflammation during I/R injury. Overall, our findings suggest that high doses of vitamin B12 might serve as an effective strategy for treating myocardial damage from I/R events, potentially paving the way for new therapies in heart health.

9.5

Neuroprotection

Most Useful Review

Unlike cyanocobalamin, methylcobalamin is notably better absorbed and is active. It aids neuronal function and can help with conditions like Alzheimer's and heart disease. The recommended dosage is safe, and any excess is excreted. I appreciate the small, sweet tablets that dissolve effectively in my mouth for optimal absorption.

Vitamin B Hypersensitivity: A Retrospective Multicenter Study.

Most Relevant Research

We explored a group of 29 patients who were referred to three allergy centers in the UK due to suspected vitamin B12 hypersensitivity (VB12H). Over the period from 2014 to 2022, these patients underwent various tests, including skin prick tests and drug provocation tests. The aim was to understand how vitamin B12 treatment relates to allergies and to develop a reliable method for assessing hypersensitivity.

Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.

Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.

Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.

8.3

Family-friendly

Most Useful Review

I try to take B12 in courses, needing one can per course. It has helped me feel better and has not caused any allergies in my family.

Constipation

Prevents constipation

This product is very nice. It helps my muscles and reduces fatigue. The clean ingredients do not lead to constipation, and it tastes excellent. It is also beneficial for the nervous system.

Ear Infection

I bought this for postherpetic neuralgia, hoping it would help with my ear infection symptoms that lingered after three years of illness. I took two tablets a day, morning and evening, and felt improvement. Although I changed to one tablet after losing one, I worried about pain returning. I wish I’d known sooner that I could have found relief.

Knee Pain

I was concerned about my right elbow pain and learned methylcobalamin can help with joint pain and numbness. After reading reviews about its effective absorption under the tongue, I decided to buy it. Consequently, my elbow pain has vanished, and I now use it regularly.

Breast Cancer

Vitamin B12 may reduce breast cancer

Folic acid supplement use and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a case-control study.

Most Relevant Research

We explored the impact of vitamin B12 supplement use on breast cancer risk among women with BRCA mutations. In a case-control study involving 129 breast cancer patients and 271 healthy controls, we evaluated the relationship between dietary supplements, including folic acid and vitamin B12, and breast cancer incidence.

Our findings revealed that women who took vitamin B12 supplements showed a significant decrease in breast cancer risk when compared to those who did not use these supplements. Specifically, moderate B12 intake was linked to a 52% reduction in risk.

Importantly, this association was most pronounced in women carrying the BRCA1 mutation. These results suggest that vitamin B12, in conjunction with folic acid supplements, may contribute to a lower risk of developing breast cancer among those genetically predisposed to the disease.

However, we recommend further studies to confirm these findings, as more extensive research with larger participant groups would help solidify our understanding of vitamin B12's benefits in this context.

2.5

Cancer recurrence risk

Most Useful Review

I was using Methyl B-12 but had to stop after a CBC revealed my vitamin B-12 level was extraordinarily high. Having previously had breast cancer, I learnt that taking B-12 may increase the likelihood of cancer returning, according to my nutritionist and various articles I discovered. While it might be beneficial for some, it’s certainly not suitable for me.

Nausea

Vitamin B12's role in nausea unclear

USERS' SCORE

Good

Based on 6 Reviews

May headache be the first sign of mutation in the MTHFR gene?

Most Relevant Research

We explored the role of vitamin B12 in treating nausea related to cerebral venous thrombosis (CVT). In a case study involving a 28-year-old man, we noted that after undergoing treatment with heparin, warfarin, and vitamin B12, his nausea improved along with his persistent headache symptoms.

Although we observed positive outcomes associated with this vitamin, it was part of a broader treatment approach rather than a standalone intervention. The study indicated that the combination of these treatments effectively alleviated nausea, but we cannot draw firm conclusions on vitamin B12's isolated impact due to the lack of control or blinding in the study design.

Overall, while vitamin B12 may have contributed to symptom relief, we must recognize that its specific role remains uncertain within the context of CVT treatment. Further studies would be needed to better define its effectiveness solely for nausea.

9.5

Nausea improved

Most Useful Review

Helps with anaemia and B12 deficiency! After starting Jarrow's Methyl B12, iron bisglycinate, and folate, my B12 and iron levels returned to normal. I now feel energised; no nausea or dizziness. The chewable tablets are pleasant to taste (I take lemon) and dissolve quickly. This effective supplement contains methylcobalamin, which is well absorbed. I trust the Jarrow brand!

Prostate Cancer

Vitamin B12 may raise cancer risk

Based on 5 Researches

Plasma folate, vitamin B12, and homocysteine and prostate cancer risk: a prospective study.

Most Relevant Research

We examined the connection between vitamin B12 levels and the risk of prostate cancer through a study involving 254 men diagnosed with prostate cancer and 514 matched controls. Our findings revealed a surprising and significant link between higher plasma levels of vitamin B12 and an increased risk of developing prostate cancer.

Specifically, the data showed that men in the highest quartile of vitamin B12 levels had nearly three times the risk compared to those in the lowest quartile. This suggests that rather than offering protection, elevated vitamin B12 may play a role in stimulating cancer’s development.

In our analysis, we also looked at plasma folate and homocysteine levels, which are important in the body’s methyl group metabolism and DNA methylation processes. While higher levels of folate were related to increased prostate cancer risk, the findings for homocysteine were not as clear-cut, showing a borderline reduced risk.

Overall, the results from this prospective study suggest that increasing vitamin B12 might be more dangerous than helpful in relation to prostate cancer, urging a reevaluation of how we view vitamin B12 in the context of cancer risk factors.

Concerns regarding B-12

Most Useful Review

I previously used Methyl B-12 but had to stop. My recent CBC indicated my vitamin B-12 level was exceedingly high. Given my history of breast cancer, I learnt from various articles and my nutritionist that taking B-12 could increase the risk of cancer recurrence. It seems beneficial, but it's not suitable for me.

Insomnia

Vitamin B12 promotes sleep in rats

Effects of intravenously administered vitamin B12 on sleep in the rat.

Most Relevant Research

We sought to determine the impact of vitamin B12 (VB12) on sleep patterns in rats, particularly considering its potential benefits for those struggling with insomnia. By giving rats a daily intravenous dose of VB12, we monitored their sleep using polysomnographic recordings over a four-day period.

During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.

Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.

9.5

Improved sleep quality

Most Useful Review

I confirm the results on myself! After giving birth, I experienced constant fatigue and insomnia. Initially, I didn't see any effects from the tablets, but I persevered. Gradually, I realised these vitamins are highly effective for me: I now fall asleep quicker, return to sleep effortlessly after waking during the night, and feel more refreshed in the morning. I strongly recommend this for anyone struggling with insomnia, especially fellow mothers!

Chronic Cough

Means of fatigue helps combat chronic fatigue and adds strength. I take it alongside folic acid.

Acne

Vitamin B12 causes acne-like eruptions

Acneiform eruptions caused by vitamin B12: A report of five cases and review of the literature.

Most Relevant Research

We observed five notable cases of acneiform eruptions linked to vitamin B12 in women aged 21 to 62. These eruptions manifested between one week and five months after starting vitamin B12 therapy.

The primary symptoms consisted of papules and pustules appearing mainly on the face. In three of the patients, these skin issues also extended to areas like the neck, shoulders, chest, and upper back, but interestingly, there were no signs of comedones or cysts.

Out of the five women, two had particularly high levels of vitamin B12 in their blood. A closer look at one patient's skin under a microscope revealed eosinophilic folliculitis, a type of inflammation in hair follicles. Fortunately, all patients experienced spontaneous and complete recovery within three to six weeks after stopping vitamin B12 treatment.

Overall, while vitamin B12 did not provide a benefit for acne treatment, it highlighted an unusual side effect of acne-like symptoms in these cases.

1.3

Intense acne

Most Useful Review

I was advised to take this product by my naturopath as I'm low in B12, but I would caution those prone to acne. It caused intense cystic acne for me, a condition I had never really dealt with before.

Headache