Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B₁₂ (as Methylcobalamin)
1,000 mcg
41,667%
The product is found useful for the following medical conditions
Autoimmune Disorder details
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.6
USERS' SCORE
Good
Based on 23 Reviews
8.7
9
We examined a case of a 51-year-old Ugandan man who experienced recurring lower limb weakness linked to pernicious anemia, an autoimmune condition causing vitamin B12 deficiency. After initial treatments, his symptoms reappeared, leading to further testing that confirmed the diagnosis.
Treatment with vitamin B12 injections significantly improved his condition. This case emphasizes the need for healthcare providers to recognize the signs of vitamin B12 deficiency early, particularly in resource-limited settings, to ensure timely diagnosis and treatment.
Treatment with vitamin B12 injections significantly improved his condition. This case emphasizes the need for healthcare providers to recognize the signs of vitamin B12 deficiency early, particularly in resource-limited settings, to ensure timely diagnosis and treatment.
9
Improved B12 levels
Most Useful Review
108 people found this helpful
The best B12 I have ever tried! I had a severe B12 deficiency for many years, and no prescription medication worked. I shifted to methylcobalamin, achieving stable levels of 700-800 nmol/L. I recommend a good B complex alongside B12 supplementation to avoid masking other deficiencies. Methylcobalamin has helped me significantly, and my bloodwork reflects the improvement.
Common Cold details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.6
9
Strengthened immunity
Most Useful Review
7 people found this helpful
Great supplement! My doctor, a neurologist, prescribed this to support my nervous system, especially as I was experiencing bothersome tinnitus. The tablets are small and have a slightly sweet lemon flavour. I was pleased with its effectiveness; I did not catch a common cold this autumn, and my immunity felt stronger. My joint mobility improved, sleep was better, and it helped stabilise my overall psychological state. Excellent dietary supplement at a budget-friendly price!
Blurred Vision details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.5
10
No more dizziness
Most Useful Review
1 people found this helpful
This product is excellent. My mother has taken it for a long time. Previously, she experienced dizziness and blurred vision; however, she no longer suffers from these issues.
Bruise details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 2 Reviews
8.5
8
We examined the case of a 38-year-old male who experienced bruising and fatigue due to isolated thrombocytopenia, a condition marked by a low platelet count. This situation was particularly interesting because the underlying cause turned out to be a significant deficiency in vitamin B12, which is quite rare in adults when it comes to isolated thrombocytopenia. As we explored the case, we found that the patient's vitamin B12 levels were extraordinarily low, prompting treatment with subcutaneous mecobalamin, a form of vitamin B12.
After several doses, not only did the vitamin B12 levels increase, but so did the platelet count, contributing to the resolution of the bruising issue. This highlights the role that vitamin B12 can play in improving hematological health, specifically in cases of thrombocytopenia. Although the lack of hypersegmented neutrophils usually linked to vitamin B12 deficiency was noted, it emphasized the complex nature of diagnosing such conditions and the need for careful evaluation of symptoms and lab results.
After several doses, not only did the vitamin B12 levels increase, but so did the platelet count, contributing to the resolution of the bruising issue. This highlights the role that vitamin B12 can play in improving hematological health, specifically in cases of thrombocytopenia. Although the lack of hypersegmented neutrophils usually linked to vitamin B12 deficiency was noted, it emphasized the complex nature of diagnosing such conditions and the need for careful evaluation of symptoms and lab results.
9
Restored ferritin levels
Most Useful Review
My gynecologist prescribed B-12 due to dysbacteriosis and low ferritin, which caused fatigue and bruising under my eyes. This supplement helped raise my ferritin levels and alleviated all related symptoms. I chew the tablets as they take time to dissolve, and I find them quite pleasant to taste.
Blood Clot details
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.9
USERS' SCORE
Good
Based on 5 Reviews
8.4
8
We examined a case involving a 56-year-old male who suffered from severe vitamin B12 deficiency. This deficiency led to dangerously high homocysteine levels, which are associated with blood clot formation. Despite effective treatment with B12, this case illustrates that vitamin deficiency can lead to significant health issues, including thrombosis and embolism.
The patient’s condition improved with B12 injections, but the interplay between low vitamin levels and clotting risks was evident. It’s clear that while vitamin B12 treatment can help, avoiding complications like blood clots remains crucial.
The patient’s condition improved with B12 injections, but the interplay between low vitamin levels and clotting risks was evident. It’s clear that while vitamin B12 treatment can help, avoiding complications like blood clots remains crucial.
9
Reduced homocysteine levels
Most Useful Review
72 people found this helpful
Vitamin B12 effectively reduces homocysteine, vital for cardiovascular health. My husband’s blood tests revealed his homocysteine levels decreased from 12 to 8 μmol/l after using this product, which indicates an impressive improvement. It's especially important for managing blood clot risks as we age. We intend to use it regularly.
Diabetes details
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.9
USERS' SCORE
Good
Based on 6 Reviews
8.4
8
We explored a novel oral delivery system using vitamin B12, fucoidan, and concanavalin A to enhance insulin effectiveness for diabetes management. This smart nanosystem targets inflammation while regulating blood glucose levels efficiently. Our findings indicated that when tested on type I diabetic mice, the nanosystem significantly lowered blood sugar and reduced inflammatory markers, such as TNF-α and interleukin-6. Notably, the system ensures safe and effective delivery, presenting a promising alternative to traditional insulin methods.
8
Supports diabetes management
Most Useful Review
1 people found this helpful
I use it alongside diabetes management. I constantly take B12 as a separate supplement because it depletes when using diabetes pills long-term. This product is chewable and pleasant tasting, making it enjoyable to consume. I will surely repurchase.
High Cholesterol details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.5
USERS' SCORE
Good
Based on 6 Reviews
8.4
9
We focused on whether white button mushrooms could help lower cholesterol levels and blood sugar in rats. In our study, we found that after three weeks of the mushroom powder, diabetic rats showed significant drops in glucose and triglyceride levels.
Furthermore, in hypercholesterolemic rats, a four-week treatment led to impressive reductions in total cholesterol and LDL cholesterol. Overall, these findings suggest that white button mushrooms may have beneficial effects on cholesterol and blood sugar management, at least in rat models.
Furthermore, in hypercholesterolemic rats, a four-week treatment led to impressive reductions in total cholesterol and LDL cholesterol. Overall, these findings suggest that white button mushrooms may have beneficial effects on cholesterol and blood sugar management, at least in rat models.
9
Desired levels achieved
Most Useful Review
I purchased this for my parents, and after a month of use, both have reached the desired levels: my father at 670 and my mother exceeding the limit at 1138. I highly recommend this vitamin. The package was well done, offering good value for money. This is my first purchase, and it arrived in Brazil within a few days.
Irritable Bowel Syndrome details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 4 Reviews
8.4
8
We examined how dietary guidance affects irritable bowel syndrome (IBS) symptoms and quality of life, particularly focusing on vitamin B12 intake. Our study involved 46 patients diagnosed with IBS based on established criteria, with 17 completing the entire program.
Through three sessions of personalized dietary advice, each lasting about 45 minutes, we found a significant reduction in IBS symptoms after the patients implemented the dietary changes. Their quality of life scores also improved notably. Although we noted an increase in vitamin B12 intake, it's important to emphasize that we did not isolate its effects from those of other dietary changes.
Interestingly, while our guidance helped patients enhance their overall nutrient intake, including vitamins and minerals, the increase in vitamin B12 specifically was the only change that reached statistical significance. However, we found no substantial differences in overall caloric or macronutrient intake among the participants.
In conclusion, while dietary guidance showed promising benefits for managing IBS symptoms and overall life quality, the impact of vitamin B12 alone remains unclear, as other dietary modifications may have played a role. Our findings suggest that individualized dietary counseling is a viable option in IBS management.
Through three sessions of personalized dietary advice, each lasting about 45 minutes, we found a significant reduction in IBS symptoms after the patients implemented the dietary changes. Their quality of life scores also improved notably. Although we noted an increase in vitamin B12 intake, it's important to emphasize that we did not isolate its effects from those of other dietary changes.
Interestingly, while our guidance helped patients enhance their overall nutrient intake, including vitamins and minerals, the increase in vitamin B12 specifically was the only change that reached statistical significance. However, we found no substantial differences in overall caloric or macronutrient intake among the participants.
In conclusion, while dietary guidance showed promising benefits for managing IBS symptoms and overall life quality, the impact of vitamin B12 alone remains unclear, as other dietary modifications may have played a role. Our findings suggest that individualized dietary counseling is a viable option in IBS management.
9
Improved gut health
Most Useful Review
19 people found this helpful
Leaky Gut syndrome led to a deficiency in vitamin B12. While overcoming this condition, my teacher Cairo recommended a lozenge form for better absorption. Since the absorption was poor due to my weak stomach mucosa, I take it twice a day, enjoying its lemon flavour. My sleep improved, and I feel my leaky gut symptoms have almost disappeared after six months. This affordable option has been effective for me.
Nausea details
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.1
USERS' SCORE
Good
Based on 7 Reviews
8.4
9
We observed how vitamin B12 deficiency can masquerade as serious conditions like hematologic malignancies, causing symptoms such as dizziness, nausea, and leukopenia. In our evaluation of a 39-year-old male, we found that treating severe B12 deficiency led to significant improvement in his blood counts.
After intensive vitamin B12 injections, his symptoms, including nausea, diminished, demonstrating the importance of assessing nutritional deficiencies before pursuing more invasive diagnoses. This case highlights how addressing vitamin B12 deficiency can effectively resolve challenging medical scenarios.
After intensive vitamin B12 injections, his symptoms, including nausea, diminished, demonstrating the importance of assessing nutritional deficiencies before pursuing more invasive diagnoses. This case highlights how addressing vitamin B12 deficiency can effectively resolve challenging medical scenarios.
9
Effective relief
Most Useful Review
69 people found this helpful
For two years, I endured severe esophageal spasms and indigestion daily. Nothing worked until I read about B-12 deficiency causing digestive issues—likely since I'd had my gallbladder removed. After trying this, I felt about 80% better within days, with continued improvement. My doctor scoffs at this, but after two years of torture, it has worked for me.
Shingles details
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.1
USERS' SCORE
Good
Based on 3 Reviews
8.4
8
We conducted a review of randomized controlled trials to determine the effectiveness of vitamin B12 in treating postherpetic neuralgia (PHN), a painful condition following shingles. Our analysis included data from databases such as PubMed and Cochrane Library, focusing specifically on trials that measured pain relief outcomes.
Our findings indicate that vitamin B12 supplementation has a significant positive effect on reducing pain levels in PHN patients. In fact, those who received vitamin B12 experienced a notable decrease in pain compared to those on placebo, with a reduction in the pain score of about four points. This result suggests that vitamin B12 not only helps with pain relief but also enhances overall quality of life for individuals suffering from this distressing condition.
Additionally, we observed a drop in the number of patients relying on analgesics, pointing to a potential alternative treatment avenue with vitamin B12. Although the evidence is moderate in quality, it presents a compelling case for the use of vitamin B12 as a complementary therapy for managing pain associated with shingles.
Our findings indicate that vitamin B12 supplementation has a significant positive effect on reducing pain levels in PHN patients. In fact, those who received vitamin B12 experienced a notable decrease in pain compared to those on placebo, with a reduction in the pain score of about four points. This result suggests that vitamin B12 not only helps with pain relief but also enhances overall quality of life for individuals suffering from this distressing condition.
Additionally, we observed a drop in the number of patients relying on analgesics, pointing to a potential alternative treatment avenue with vitamin B12. Although the evidence is moderate in quality, it presents a compelling case for the use of vitamin B12 as a complementary therapy for managing pain associated with shingles.
9
Pain relief
Most Useful Review
1 people found this helpful
I have been using this product for years, learning that cobalamin is vital for recovery from illness. When I developed shingles, I increased my intake and saw the growth of new shingles stop, with healing occurring without blistering. The pain subsided after taking one tablet daily, so I didn't need to go to the hospital; this product is fantastic!
Ulcer details
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.8
USERS' SCORE
Good
Based on 5 Reviews
8.4
9
We delved into the complexities surrounding a specific genetic mutation in the LMBRD1 gene, which is linked to a variant form of cobalamin (vitamin B12) deficiency. This study highlighted a 15-year-old male with symptoms typical of Dyskeratosis Congenita, including skin hyperpigmentation and ulcers. After identifying a novel splice site deletion in the gene, we learned that this alteration can heavily impact vitamin B12 metabolism and lead to various clinical manifestations, including ulcers.
Importantly, we observed the effects of administering intravenous hydroxocobalamin therapy. Following treatment, our findings indicated a notable improvement in the patient's skin hyperpigmentation, angular cheilitis, and the painful aphthous ulcers. While the study primarily focused on genetic factors and treatment responses, the results suggested that vitamin B12 therapy plays a valuable role in alleviating ulcer symptoms. We encourage further exploration to expand our understanding of these relationships and optimize treatment approaches.
Importantly, we observed the effects of administering intravenous hydroxocobalamin therapy. Following treatment, our findings indicated a notable improvement in the patient's skin hyperpigmentation, angular cheilitis, and the painful aphthous ulcers. While the study primarily focused on genetic factors and treatment responses, the results suggested that vitamin B12 therapy plays a valuable role in alleviating ulcer symptoms. We encourage further exploration to expand our understanding of these relationships and optimize treatment approaches.
9
Effective treatment
Most Useful Review
B12 has been beneficial for my mouth ulcers.
Depression details
SCIENTIFIC SCORE
Questionable
Based on 21 Researches
6.9
USERS' SCORE
Good
Based on 16 Reviews
8.3
8
We explored the connection between vitamin B levels and depression in older adults over four years. Our study followed nearly 3,850 participants and found that those with low blood levels of vitamin B were significantly more likely to report depressive symptoms. Specifically, individuals with low vitamin B had a 51% higher chance of developing depression compared to those with adequate levels.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults.
9
Supports emotional stability
Most Useful Review
69 people found this helpful
Methylcobalamin has shown effects for me! As a nerve vitamin, it assists in nerve repair and regeneration. I discovered it helps with my moods, particularly with depression. I believe it can benefit empaths and those sensitive to their surroundings when paired with vitamin C.
Hair Loss details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 6 Reviews
8.3
9
Stopped hair loss
Most Useful Review
19 people found this helpful
One of the best supplements to increase energy and lower homocysteine! This B12, in the form of Methylcobalamin, from a great Jarrow brand, has worked perfectly for me. My blood tests revealed that my B12 levels, previously low, are now over 600 ng/mL. I combine it with Methyl Folate for better absorption. Since starting this protocol, I have noticed a significant reduction in hair loss, with real hair growth and a healthier appearance. My memory and mental clarity have also greatly improved. My doctor recommended I supplement with brewer’s yeast to maintain overall B vitamin levels. If my comment is helpful to you, please give a JOINHA (👍🏻).
Heart Attack details
SCIENTIFIC SCORE
Likely Ineffective
Based on 2 Researches
3
USERS' SCORE
Good
Based on 2 Reviews
8.3
4
Vitamin B12 shows no heart attack benefit
In a recent study, we delved into the role of homocysteine thiolactone, a metabolite linked to heart disease, in predicting the risk of acute myocardial infarction (AMI). Conducted with a sizable group of 2049 patients suspected of having coronary artery disease (CAD), the trial was meticulously designed as a double-blind clinical intervention.
Participants were divided randomly into four distinct groups, receiving a combination of folic acid and other B vitamins or a placebo. Notably, we measured urinary levels of homocysteine thiolactone at different points throughout the study to draw correlations with heart attack incidents.
Our analysis revealed that while the homocysteine thiolactone/creatinine ratio was a significant predictor of AMI risk, there was no observable effect from the vitamin B treatments received by participants. This suggests that vitamin B12, when part of a group of B vitamins, did not independently influence the likelihood of having a heart attack.
Ultimately, we found that higher levels of homocysteine thiolactone correlated with a greater risk of AMI, but the combination of vitamin B treatments did not alter this outcome. This points to the potential of homocysteine thiolactone as an important marker in understanding cardiovascular health.
Participants were divided randomly into four distinct groups, receiving a combination of folic acid and other B vitamins or a placebo. Notably, we measured urinary levels of homocysteine thiolactone at different points throughout the study to draw correlations with heart attack incidents.
Our analysis revealed that while the homocysteine thiolactone/creatinine ratio was a significant predictor of AMI risk, there was no observable effect from the vitamin B treatments received by participants. This suggests that vitamin B12, when part of a group of B vitamins, did not independently influence the likelihood of having a heart attack.
Ultimately, we found that higher levels of homocysteine thiolactone correlated with a greater risk of AMI, but the combination of vitamin B treatments did not alter this outcome. This points to the potential of homocysteine thiolactone as an important marker in understanding cardiovascular health.
7.5
Enhances cardiovascular health
Most Useful Review
This supplement is beneficial for the nervous system and supports the brain and spinal cord. It helps the cardiovascular system by preventing thrombus formation, reducing the risk of atherosclerosis, heart attack, and stroke, while also normalising blood pressure.
Hypothyroidism details
SCIENTIFIC SCORE
Likely Ineffective
Based on 4 Researches
4.8
USERS' SCORE
Good
Based on 2 Reviews
8.3
7
We explored the connection between vitamin B12 deficiency and hypothyroidism through a focused study involving 100 hypothyroid patients. This research took place over a year and aimed to determine how common vitamin B12 deficiency is among these individuals and how it correlates with thyroid antibodies.
Our findings revealed that a significant 68% of the hypothyroid patients were vitamin B12 deficient. Interestingly, a large majority of these deficient patients were female, specifically 73.5%. Additionally, we noted that a high percentage of patients with elevated Anti TPO and Anti Thyroglobulin antibodies also had low vitamin B12 levels.
Although vitamin B12 deficiency was present in a notable portion of the hypothyroid population, we're careful to point out that the study does not state that vitamin B12 supplementation alone can fully alleviate hypothyroid symptoms. However, it suggests that addressing this deficiency could be a valuable addition to current hypothyroid treatments. By recognizing and treating vitamin B12 deficiency, we may improve the overall management of hypothyroid conditions for some patients.
Our findings revealed that a significant 68% of the hypothyroid patients were vitamin B12 deficient. Interestingly, a large majority of these deficient patients were female, specifically 73.5%. Additionally, we noted that a high percentage of patients with elevated Anti TPO and Anti Thyroglobulin antibodies also had low vitamin B12 levels.
Although vitamin B12 deficiency was present in a notable portion of the hypothyroid population, we're careful to point out that the study does not state that vitamin B12 supplementation alone can fully alleviate hypothyroid symptoms. However, it suggests that addressing this deficiency could be a valuable addition to current hypothyroid treatments. By recognizing and treating vitamin B12 deficiency, we may improve the overall management of hypothyroid conditions for some patients.
7.5
Enhanced mood
Most Useful Review
Remarkable for mood and energy, but be cautious of breakouts! I’ve tried numerous supplements and nothing has affected me this positively and quickly. This sublingual B12 has significantly improved my mood swings, energy, and concentration. I’m pleased to have tried it for my anaemia related to hypothyroidism. However, I may need to reduce the dosage due to hairline and back acne reactions caused by high B12 levels.
Liver Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.7
USERS' SCORE
Good
Based on 3 Reviews
8.3
9
We explored how methylcobalamin, a form of vitamin B12, impacts liver disease, particularly in the context of cholestatic liver failure. The study utilized high-throughput screening to identify methylcobalamin as a specific inhibitor of gasdermin E (GSDME), a protein that plays a key role in pyroptotic cell death—a form of inflammatory cell death contributing to liver damage.
Our findings showed that when tested on mouse models with liver failure due to cholestasis, cisplatin, or concanavalin A, methylcobalamin effectively reduced liver damage. It significantly lowered liver transaminase levels, indicating less liver inflammation and cellular injury, and helped alleviate overall liver cell death.
Furthermore, methylcobalamin worked by preventing the cleavage of GSDME, which is essential for uncontrolled inflammatory cell death. By binding to a specific site on the GSDME protein, it blocked the interactions that trigger this damaging process. Overall, our study highlighted the potential of methylcobalamin as a promising therapeutic option for managing cholestatic liver failure and related conditions.
Our findings showed that when tested on mouse models with liver failure due to cholestasis, cisplatin, or concanavalin A, methylcobalamin effectively reduced liver damage. It significantly lowered liver transaminase levels, indicating less liver inflammation and cellular injury, and helped alleviate overall liver cell death.
Furthermore, methylcobalamin worked by preventing the cleavage of GSDME, which is essential for uncontrolled inflammatory cell death. By binding to a specific site on the GSDME protein, it blocked the interactions that trigger this damaging process. Overall, our study highlighted the potential of methylcobalamin as a promising therapeutic option for managing cholestatic liver failure and related conditions.
9
Memory improvement
Most Useful Review
1 people found this helpful
B12 greatly influences memory. After experiencing memory decline at 70, I had a blood test to check my B12 levels. I started chewing one tablet daily, and I’ve noticed significant improvement in my memory. My family also takes it, and it's genuinely helpful for maintaining cognitive function, especially concerning liver disease.
Menopause details
SCIENTIFIC SCORE
Likely Very Effective
Based on 2 Researches
9
USERS' SCORE
Good
Based on 5 Reviews
8.3
9
Vitamin B12 may aid menopause relief
We observed the effects of a nutritional product that combined various ingredients, including vitamin B12, on menopausal symptoms. This study involved 156 menopausal women who took the product daily for 12 weeks and reported their symptoms using a validated scale.
After completing the study, we found significant reductions in various menopause-related issues. This included a substantial 45% decrease in depressive mood and a notable reduction of 48% in hot flashes. It's important to note that while vitamin B12 was included in the treatment, it was part of a broader combination with other beneficial ingredients.
However, we must clarify that the specific impact of vitamin B12 alone cannot be fully determined from this study. The results are promising for the product as a whole, showing effective relief from many menopausal symptoms, but further research is needed to isolate the role of vitamin B12 in managing these symptoms.
After completing the study, we found significant reductions in various menopause-related issues. This included a substantial 45% decrease in depressive mood and a notable reduction of 48% in hot flashes. It's important to note that while vitamin B12 was included in the treatment, it was part of a broader combination with other beneficial ingredients.
However, we must clarify that the specific impact of vitamin B12 alone cannot be fully determined from this study. The results are promising for the product as a whole, showing effective relief from many menopausal symptoms, but further research is needed to isolate the role of vitamin B12 in managing these symptoms.
9
Better sleep
Most Useful Review
Great product. I sleep better after taking it. It helps stabilise my autonomic nervous system during menopause. The quality is very good and the price is reasonable.
Neuropathy details
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.5
USERS' SCORE
Good
Based on 15 Reviews
8.3
8
We explored the effects of vitamin B12 deficiency on neurological health in elderly patients. In a case study involving two patients, we observed that even with normal B12 levels, symptoms like fatigue and cognitive impairment persisted, especially in those with significant medical histories.
Treatment with hydroxocobalamin injections led to notable improvements in both patients’ cognitive and motor functions. This highlights the importance of recognizing vitamin B12 deficiency in older adults, even when traditional tests suggest adequate levels.
Treatment with hydroxocobalamin injections led to notable improvements in both patients’ cognitive and motor functions. This highlights the importance of recognizing vitamin B12 deficiency in older adults, even when traditional tests suggest adequate levels.
10
Numbness alleviated
Most Useful Review
7 people found this helpful
B12 improves peripheral neuropathy. After taking the first tablet, the numbness in my right foot, which persisted for over three years, has almost completely disappeared. I was surprised by its immediate effect, and I believe my previous diet influenced my condition.
Reflux details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.3
8
No worsening reflux
Most Useful Review
Nice! It tastes alright and seems strong enough while dissolving well without aggravating my reflux. I took this to help elevate my blood platelets, an issue from chemotherapy. I'm impressed with the quality, especially for the price.
Swollen Lymph Nodes details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.3
9
Swelling reduced quickly
Most Useful Review
This highly digestible form of B12 is superb in taste and acts quickly. The swelling on my tongue, which was a symptom of B12 deficiency, disappeared in just five days. It’s essential for vegetarians like myself.
Alzheimer details
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6
USERS' SCORE
Good
Based on 4 Reviews
8.2
4
We explored the potential role of vitamin B12, alongside folic acid, in slowing the progression of Alzheimer's disease (AD) through a meta-analysis of randomized control trials. Our aim was to determine whether these supplements might improve cognitive function, daily life activities, and influence blood homocysteine levels in individuals diagnosed with AD.
After carefully sifting through studies, we found five that met our criteria. These studies assessed the cognitive changes in participants through the Mini-Mental State Examination (MMSE) and the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog). Additionally, they examined the impact on daily functioning as well as blood homocysteine levels.
The results showed that after six months of treatment, participants taking vitamin B12 and folic acid did experience a slight improvement in MMSE scores compared to those on a placebo. However, there was no significant change in the ADAS-Cog scores, which means some cognitive aspects didn’t show marked improvement. Likewise, daily life functioning did not see any benefits from the supplements.
Importantly, we also noted a significant reduction in blood homocysteine levels following the supplementation, suggesting a biochemical effect of the treatment. Overall, while vitamin B12 shows promise in enhancing some cognitive measures, it does not translate directly into broader cognitive or daily functioning improvements in Alzheimer's patients.
After carefully sifting through studies, we found five that met our criteria. These studies assessed the cognitive changes in participants through the Mini-Mental State Examination (MMSE) and the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog). Additionally, they examined the impact on daily functioning as well as blood homocysteine levels.
The results showed that after six months of treatment, participants taking vitamin B12 and folic acid did experience a slight improvement in MMSE scores compared to those on a placebo. However, there was no significant change in the ADAS-Cog scores, which means some cognitive aspects didn’t show marked improvement. Likewise, daily life functioning did not see any benefits from the supplements.
Importantly, we also noted a significant reduction in blood homocysteine levels following the supplementation, suggesting a biochemical effect of the treatment. Overall, while vitamin B12 shows promise in enhancing some cognitive measures, it does not translate directly into broader cognitive or daily functioning improvements in Alzheimer's patients.
7.5
Neuroprotective effects
Most Useful Review
6 people found this helpful
Unlike cyanocobalamin, methylcobalamin is a naturally occurring form of vitamin B12, better absorbed in our bodies. It supports lipid production and nerve regeneration, making it beneficial for Alzheimer's. A starting dose of 1000mcg is safe, as excess amounts are excreted. The small, sweet tablets should be held in the mouth until they dissolve. The price is reasonable.
Bone Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 22 Reviews
8.2
9
Increased energy
Most Useful Review
I take Vitamin B12 for red blood cell formation and nerve health due to a deficiency shown in my analysis. This vitamin is necessary as its absence can cause fatigue, bone pain, and memory issues. The methylcobalamin form is effectively absorbed by the body.
Celiac details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.2
7.5
Life-changing formula
Most Useful Review
Gluten-free methyl-B12 Jarrow's methyl-B12 formulations have completely transformed my life. I would advise against taking cyanocobalamin! These gluten-free formulations are fantastic for individuals with celiac disease.
Cold details
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.3
USERS' SCORE
Good
Based on 8 Reviews
8.2
8
We explored the potential effects of vitamin B12 on cold sensitivity in a study using rats with induced neuropathic pain. The focus was to see whether vitamin B12, both alone and in combination with the pain reliever diclofenac, could alleviate cold and mechanical allodynia—a condition where non-painful stimuli are perceived as painful.
In our approach, we administered vitamin B12 in varying doses over ten consecutive days following nerve injury. What we discovered was quite telling. Higher doses of vitamin B12 (50, 100, and 200 µg kg(-1)) led to a reduction in cold sensitivity. However, when using a lower, subanalgesic dose (25 µg kg(-1)), vitamin B12 did not significantly impact pain responses when paired with low doses of diclofenac.
As we adjusted the vitamin B12 dosage to a more effective level (100 µg kg(-1)), we noticed an improvement in pain relief compared to diclofenac alone. These findings suggest that vitamin B12 could have a positive effect on alleviating cold-related pain in neuropathic conditions, especially when used at appropriate doses.
In our approach, we administered vitamin B12 in varying doses over ten consecutive days following nerve injury. What we discovered was quite telling. Higher doses of vitamin B12 (50, 100, and 200 µg kg(-1)) led to a reduction in cold sensitivity. However, when using a lower, subanalgesic dose (25 µg kg(-1)), vitamin B12 did not significantly impact pain responses when paired with low doses of diclofenac.
As we adjusted the vitamin B12 dosage to a more effective level (100 µg kg(-1)), we noticed an improvement in pain relief compared to diclofenac alone. These findings suggest that vitamin B12 could have a positive effect on alleviating cold-related pain in neuropathic conditions, especially when used at appropriate doses.
9
Strengthened immunity
Most Useful Review
7 people found this helpful
Great drug! My doctor, a neurologist, prescribed this to maintain my nervous system, which was vital as I found the noise in my ears very disturbing. I had to place the tablets in my mouth for quicker results. The small plates have a slightly sweet lemon flavour. I was pleased with its effectiveness; I didn't catch a cold this autumn, and my immunity was fortified. Joint mobility significantly increased, with no more crunching, and my sleep has improved. This vitamin helped stabilise my overall psychological state, and my nervous system is now fine. An excellent dietary supplement at a budget price!
Flu details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 10 Reviews
8.2
10
Sickness prevention
Most Useful Review
1 people found this helpful
I take B12 as part of an immune boost to help prevent shingles, as my mother suffered severely. After researching ways to boost my immune system, I found this combination. Since starting it, I haven't been ill once, not even with colds or the flu. I intend to continue using this immune support regimen to ward off sickness, including shingles.
Frozen Shoulder details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 13 Reviews
8.2
9
Effective for headaches
Most Useful Review
7 people found this helpful
Wonderful effect! The product stabilises my spirit and significantly alleviates shoulder stiffness and muscle fatigue. I found it particularly effective for tired eyes and headaches resulting from eye strain. The strength of this effect, especially at this price, is remarkable!
Migraine details
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.2
USERS' SCORE
Good
Based on 5 Reviews
8.2
7
We examined the connection between vitamin B12 serum levels and migraine, both chronic and episodic. In our study, we compared two groups: 90 individuals suffering from migraines and 90 healthy participants. We measured the serum vitamin B12 levels of all subjects using a method known as enzyme-linked immunosorbent assay (ELISA).
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
7.5
Effective for migraines
Most Useful Review
5 people found this helpful
It works well! I find this vitamin B12 beneficial for my migraines, especially considering its easy-to-take ramune form. Traditional tablet types are difficult for me to swallow. This supplement helps refresh my mind and eases neck stiffness, which contributes to my tinnitus. I particularly recommend it for anyone suffering from light sensitivity associated with migraines.
Premenstrual Syndrome details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.2
9
Good mood achieved
Most Useful Review
The taste is easy! It dissolves slowly, but I have been in a relatively good mood during my premenstrual syndrome. Thank you!!
Stroke details
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.8
USERS' SCORE
Good
Based on 4 Reviews
8.2
8
We explored the role of vitamin B12 in managing neuroinflammation after an ischemic stroke. Through preclinical studies, we observed that vitamin B12 effectively influenced microglial cells, which are key to the brain's immune response. This treatment promoted important cellular processes, leading to reduced brain damage and better neurological outcomes. However, when microglia were depleted before stroke, the positive effects of vitamin B12 disappeared. Overall, while vitamin B12 shows promise in enhancing recovery post-stroke, its impact hinges on these immune cells.
7.5
Reduces stroke risk
Most Useful Review
2 people found this helpful
This complex is truly wonderful, containing essential B vitamins (B12, B6, B9) in their active forms. They assist with chronic viral loads and lower homocysteine levels, consequently reducing the risk of cardiovascular diseases, particularly stroke. This complex is vital for the elderly who are at risk.
Anxiety details
SCIENTIFIC SCORE
Questionable
Based on 12 Researches
6.4
USERS' SCORE
Good
Based on 14 Reviews
8.1
8
We investigated the potential of vitamin B12 to mitigate anxiety in adult zebrafish subjected to chronic alcohol exposure. Our study involved exposing zebrafish to alcohol and then providing them with vitamin B12 to see if it would help reduce anxiety-related behaviors. By using a geotaxis test, we could observe how the fish responded in terms of anxiety in a controlled environment.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
9
Improves anxiety response
Most Useful Review
16 people found this helpful
With both ADHD and anxiety, I previously relied on meditation and meditation techniques. Upon reading about natural treatments for anxiety, I incorporated Methylcobalamin and Folinic Acid into my routine. The results have been remarkable; I haven't needed Xanax during the day, and my anxiety has significantly decreased. My husband, unaware of the supplements, has also noticed improved handling of daily stresses, which confirms their effectiveness.
Ear Infection details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.1
7.5
Effective treatment
Most Useful Review
5 people found this helpful
I bought this for postherpetic neuralgia, hoping it would help with my ear infection symptoms that lingered after three years of illness. I took two tablets a day, morning and evening, and felt improvement. Although I changed to one tablet after losing one, I worried about pain returning. I wish I’d known sooner that I could have found relief.
Knee Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 8 Reviews
8.1
9
Elbow pain relief
Most Useful Review
4 people found this helpful
I was concerned about my right elbow pain and learned methylcobalamin can help with joint pain and numbness. After reading reviews about its effective absorption under the tongue, I decided to buy it. Consequently, my elbow pain has vanished, and I now use it regularly.
Autism details
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.4
USERS' SCORE
Good
Based on 3 Reviews
8
4
We conducted a study that examined the levels of vitamin B12, homocysteine, and anti-parietal cell antibodies in children diagnosed with autism spectrum disorder (ASD) compared to a control group. Our research included 69 children, where 36 had ASD, and 33 were matched controls based on age, sex, and socioeconomic status. The severity of autism was assessed using the Childhood Autism Rating Scale (CARS), while serum levels were measured using a common laboratory technique called enzyme-linked immunosorbent assay.
Our findings revealed that children with ASD had significantly lower levels of vitamin B12 and homocysteine compared to their peers in the control group. However, we found no significant difference in the levels of anti-parietal cell antibodies, which suggests that vitamin B12 deficiency may not be due to absorption issues related to these antibodies. While we observed notable micronutrient deficiencies, it’s important to clarify that the study did not establish a direct benefit of vitamin B12 treatment for autism symptoms.
Importantly, this research hints at the potential role that vitamin B12 deficiencies may play in the clinical features of autism. Nonetheless, we believe that further studies involving larger populations are necessary to better understand how these micronutrient levels might influence the condition and its underlying causes.
Our findings revealed that children with ASD had significantly lower levels of vitamin B12 and homocysteine compared to their peers in the control group. However, we found no significant difference in the levels of anti-parietal cell antibodies, which suggests that vitamin B12 deficiency may not be due to absorption issues related to these antibodies. While we observed notable micronutrient deficiencies, it’s important to clarify that the study did not establish a direct benefit of vitamin B12 treatment for autism symptoms.
Importantly, this research hints at the potential role that vitamin B12 deficiencies may play in the clinical features of autism. Nonetheless, we believe that further studies involving larger populations are necessary to better understand how these micronutrient levels might influence the condition and its underlying causes.
7.5
Increased focus
Most Useful Review
13 people found this helpful
For my child with autism, trying methyl-B12 injections and nasal sprays is advised by some online. However, this Jarrow lozenge seemed much easier and at 16.67% of the recommended daily dose for methyl-B12, I found it difficult to ascertain what benefits other methods could provide. I began giving my 10-year-old son about 1-2 lozenges per week, and he appears slightly more focused. I have also introduced some additional B vitamins, including Metafolin and B6, but I don't endorse mega doses; he takes them alternately at most. He also receives vitamin D and omega-3 supplements.
Cardiovascular Disease details
SCIENTIFIC SCORE
Questionable
Based on 9 Researches
6.7
USERS' SCORE
Good
Based on 15 Reviews
8
8
We examined the role of vitamin B status on mortality rates, focusing on cardiovascular disease. Using data from over 12,000 adults, we found that higher scores on the combined vitamin B status indicator (3cB) were linked to lower risks of dying from cardiovascular issues. Specifically, individuals with lower 3cB scores faced significantly higher risks of mortality. This suggests that maintaining adequate vitamin B levels could potentially play an important part in reducing cardiovascular disease-related deaths.
9
Eased symptoms effectively
Most Useful Review
9 people found this helpful
This product has alleviated my severe folic acid and B12 deficiency symptoms, such as numbness and muscle pain. Unlike injections, these easy-to-take pills have shown remarkable results. I feel energised, and the sweet taste makes it enjoyable. I highly recommend it for overall well-being.
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.4
USERS' SCORE
Good
Based on 35 Reviews
8
0
Vitamin B12 ineffective for CFS
We explored the effectiveness of high-dose vitamin B12 injections on chronic fatigue syndrome (CFS) through two case reports that utilized N of 1 trials. This approach allowed us to make tailored treatment decisions based on individual responses to the therapy.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
9
Reduced fatigue
Most Useful Review
99 people found this helpful
Good vitamins; as recommended by my doctor for the nervous system and reducing fatigue, they accomplished just that. I highly recommend purchasing them.
Back Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 17 Researches
8.3
USERS' SCORE
Moderately Good
Based on 18 Reviews
7.9
9
We evaluated the effectiveness of intramuscular vitamin B12 in treating low back pain among 60 patients aged 18 to 65 with mechanical pain lasting at least six months.
In this double-blind, placebo-controlled study, both groups showed improvement in pain levels. However, those receiving B12 had a more significant reduction in pain and dependence on pain medication compared to the placebo group.
Overall, B12 appears to be a safe option for alleviating low back pain, helping to reduce discomfort and medication use for those without nutritional deficiencies.
In this double-blind, placebo-controlled study, both groups showed improvement in pain levels. However, those receiving B12 had a more significant reduction in pain and dependence on pain medication compared to the placebo group.
Overall, B12 appears to be a safe option for alleviating low back pain, helping to reduce discomfort and medication use for those without nutritional deficiencies.
9
Reduced foot pain
Most Useful Review
2 people found this helpful
I initially tried B12 for Morton's neuroma, and it worked wonders. I've noticed a significant reduction in foot pain and regained feeling in areas that had been numb for quite some time, highlighting the importance of B12.
Dizziness details
SCIENTIFIC SCORE
Moderately Effective
Based on 17 Researches
8.4
USERS' SCORE
Moderately Good
Based on 21 Reviews
7.9
9.5
We examined a unique case involving a 28-year-old male who experienced dizziness related to severe anemia from low vitamin B12 levels.
After treatment with daily vitamin B12 injections, his symptoms and lab values significantly improved, indicating a positive response to the treatment.
Despite the rare nature of his condition—seronegative pernicious anemia—the results suggest that B12 can effectively alleviate dizziness stemming from anemia in similar cases.
After treatment with daily vitamin B12 injections, his symptoms and lab values significantly improved, indicating a positive response to the treatment.
Despite the rare nature of his condition—seronegative pernicious anemia—the results suggest that B12 can effectively alleviate dizziness stemming from anemia in similar cases.
9
Improved dizziness relief
Most Useful Review
5 people found this helpful
This Vitamin B12 is effective! It helps with dizziness and other ailments like neck pain. The ramune type is easier to take than large tablets, making it enjoyable to continue using. I feel more refreshed, and it alleviates my tinnitus related to neck stiffness. I’d love to see more B vitamins in this form!
Leg Cramps details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 13 Reviews
7.9
7.5
Less cramping
Most Useful Review
5 people found this helpful
I recently discovered that I have the MTHFR C677T gene defect, leading to inefficient absorption of B12 and folate. I had chronic leg cramps for years, which I thought were hereditary. After adding this supplement, I've noticed significantly less cramping in my legs within a week. I appreciate the pleasant taste and plan to continue using it long-term.
Allergies details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.8
8
We investigated the potential of cyanocobalamin, or Vitamin B12, as a treatment for skin inflammation using a cutting-edge transdermal delivery system. The research focused on microneedle patches that effectively deliver this antioxidant form of Vitamin B12 into the skin.
Our findings highlighted reduced inflammation and damage in skin models, indicated by decreased cytokine levels and less oxidative stress. This approach may present a new, cost-effective method to enhance skin care for patients dealing with chronic inflammatory conditions.
However, it's important to note that while the results are promising, further studies are needed for broader applications.
Our findings highlighted reduced inflammation and damage in skin models, indicated by decreased cytokine levels and less oxidative stress. This approach may present a new, cost-effective method to enhance skin care for patients dealing with chronic inflammatory conditions.
However, it's important to note that while the results are promising, further studies are needed for broader applications.
9
Family-friendly
Most Useful Review
I try to take B12 in courses, needing one can per course. It has helped me feel better and has not caused any allergies in my family.
Tinnitus details
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
5.4
USERS' SCORE
Moderately Good
Based on 19 Reviews
7.8
1
We conducted a double-blind clinical trial with 140 patients suffering from idiopathic tinnitus to gauge the effectiveness of vitamin B12. Participants were divided into two groups, one receiving vitamin B12 and the other a placebo over a month.
We evaluated tinnitus severity through questionnaires at multiple intervals. However, our findings revealed that vitamin B12 did not significantly reduce tinnitus severity compared to the placebo.
Ultimately, our study suggests that vitamin B12 may not be a beneficial treatment for tinnitus, as the results showed no noteworthy improvements.
We evaluated tinnitus severity through questionnaires at multiple intervals. However, our findings revealed that vitamin B12 did not significantly reduce tinnitus severity compared to the placebo.
Ultimately, our study suggests that vitamin B12 may not be a beneficial treatment for tinnitus, as the results showed no noteworthy improvements.
7.5
Improved focus
Most Useful Review
5 people found this helpful
It works well! I find this vitamin B12 supplement helps with my tinnitus, neck, and intercostal neuralgia. Other B12 products did not work for me, but this one is exceptional, especially as it's in a ramune type, making it easy to take. The large tablet forms are difficult for me. It refreshes my head, relieving neck stiffness and associated tinnitus. I recommend it for migraine sufferers as well and hope they create more ramune type vitamin B supplements.
Anemia details
SCIENTIFIC SCORE
Moderately Effective
Based on 21 Researches
8.2
USERS' SCORE
Moderately Good
Based on 42 Reviews
7.7
9.5
We explored the case of a 23-month-old boy suffering from severe pancytopenia linked to Imerslund-Gräsbeck syndrome, a rare condition caused by an inability to absorb vitamin B12. Upon diagnosis, the boy received vitamin B12 replacement therapy, which effectively addressed his symptoms and improved his health.
This case highlights the significance of early detection and treatment of IGS to avoid potential neurological damage. It's crucial to recognize this condition, even when neurological symptoms are absent, to provide timely care.
This case highlights the significance of early detection and treatment of IGS to avoid potential neurological damage. It's crucial to recognize this condition, even when neurological symptoms are absent, to provide timely care.
9
Eliminated injections
Most Useful Review
35 people found this helpful
I'm unsure why others find these lozenges slow to dissolve; they are meant to melt gradually. With pernicious anaemia, I can't absorb B12 in my stomach, so I keep the lozenge between my gum and lip for absorption through the mouth. After using one daily, I no longer require injectable B12.
Constipation details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.7
7.5
Prevents constipation
Most Useful Review
This product is very nice. It helps my muscles and reduces fatigue. The clean ingredients do not lead to constipation, and it tastes excellent. It is also beneficial for the nervous system.
Heart Disease details
SCIENTIFIC SCORE
Questionable
Based on 10 Researches
6.2
USERS' SCORE
Moderately Good
Based on 12 Reviews
7.7
8
We explored the potential of high doses of vitamin B12 to protect against heart damage caused by ischemia/reperfusion injury. By researching mice subjected to heart injury, we found that vitamin B12 showed promising effects in reducing oxidative stress and improving heart function.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
9
Neuroprotection
Most Useful Review
6 people found this helpful
Unlike cyanocobalamin, methylcobalamin is notably better absorbed and is active. It aids neuronal function and can help with conditions like Alzheimer's and heart disease. The recommended dosage is safe, and any excess is excreted. I appreciate the small, sweet tablets that dissolve effectively in my mouth for optimal absorption.
Insomnia details
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.7
USERS' SCORE
Moderately Good
Based on 22 Reviews
7.7
8
Vitamin B12 promotes sleep in rats
We sought to determine the impact of vitamin B12 (VB12) on sleep patterns in rats, particularly considering its potential benefits for those struggling with insomnia. By giving rats a daily intravenous dose of VB12, we monitored their sleep using polysomnographic recordings over a four-day period.
During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.
Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.
During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.
Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.
9
Improved sleep quality
Most Useful Review
4 people found this helpful
I confirm the results on myself! After giving birth, I experienced constant fatigue and insomnia. Initially, I didn't see any effects from the tablets, but I persevered. Gradually, I realised these vitamins are highly effective for me: I now fall asleep quicker, return to sleep effortlessly after waking during the night, and feel more refreshed in the morning. I strongly recommend this for anyone struggling with insomnia, especially fellow mothers!
Mild Cognitive Impairment details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.7
9
Supports neurological health
Most Useful Review
Methyl B12 is crucial for various body functions, particularly for nerve health and DNA methylation, which is essential for gene function. It maintains normal homocysteine levels, helping to prevent cardiovascular disease and supports cognitive function. Sufficient B12 intake can help prevent Mild Cognitive Impairment, and its deficiency is linked to cognitive decline. Methyl B12 is especially vital for those with absorption issues of other B12 forms.
Sleep Apnea details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 25 Reviews
7.7
7.5
Improved sleep quality
Most Useful Review
4 people found this helpful
I confirm the result! I suffer from insomnia, feeling constantly fatigued after sleep since having my child. Initially, I saw no improvement from the tablets, but persevered. Once I persisted, I found these vitamins incredibly effective: I now fall asleep faster and remain more cheerful after waking. For anyone struggling with sleep issues, particularly fellow mothers, I wholeheartedly recommend this.
Chronic Cough details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 3 Reviews
7
0
Uncertain effectiveness
Most Useful Review
I’m unsure of its effectiveness; when I lick it, my throat becomes itchy and I start to cough, possibly a chronic cough.
Headache details
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.3
USERS' SCORE
Medium or Average
Based on 13 Reviews
6.8
8
We conducted a case-control study to investigate the link between vitamin B12 serum levels and migraine, which affects so many people but lacks a fully understood cause. Our research included 90 individuals experiencing migraines—split into those with chronic migraines and those with episodic migraines—matched against 90 healthy participants.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
9
Effective for headaches
Most Useful Review
7 people found this helpful
Wonderful effect! Firstly, the remedy is stable and has alleviated my shoulder stiffness and muscle fatigue. My tired eyes felt a relief, and it effectively treated my headaches caused by eye strain. The efficacy at this price is astounding!
Acne details
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.9
USERS' SCORE
Medium or Average
Based on 4 Reviews
6.3
9.5
We observed five notable cases of acneiform eruptions linked to vitamin B12 in women aged 21 to 62. These eruptions manifested between one week and five months after starting vitamin B12 therapy.
The primary symptoms consisted of papules and pustules appearing mainly on the face. In three of the patients, these skin issues also extended to areas like the neck, shoulders, chest, and upper back, but interestingly, there were no signs of comedones or cysts.
Out of the five women, two had particularly high levels of vitamin B12 in their blood. A closer look at one patient's skin under a microscope revealed eosinophilic folliculitis, a type of inflammation in hair follicles. Fortunately, all patients experienced spontaneous and complete recovery within three to six weeks after stopping vitamin B12 treatment.
Overall, while vitamin B12 did not provide a benefit for acne treatment, it highlighted an unusual side effect of acne-like symptoms in these cases.
The primary symptoms consisted of papules and pustules appearing mainly on the face. In three of the patients, these skin issues also extended to areas like the neck, shoulders, chest, and upper back, but interestingly, there were no signs of comedones or cysts.
Out of the five women, two had particularly high levels of vitamin B12 in their blood. A closer look at one patient's skin under a microscope revealed eosinophilic folliculitis, a type of inflammation in hair follicles. Fortunately, all patients experienced spontaneous and complete recovery within three to six weeks after stopping vitamin B12 treatment.
Overall, while vitamin B12 did not provide a benefit for acne treatment, it highlighted an unusual side effect of acne-like symptoms in these cases.
2
Severe breakouts experienced
Most Useful Review
8 people found this helpful
I experienced skin breakouts after taking this. Having previously taken B vitamins, I knew the nausea and aftertaste could be an issue, particularly since I’m pescatarian. I tried this lozenge chewable at my husband’s suggestion; it tasted good with no aftertaste. However, after a few weeks, I developed severe breakouts on my face, something I hadn’t encountered in years. Since I hadn’t changed my diet, I discovered that B12 can cause acne. My skin became sensitive and blemished, forcing me to stop taking it.
