Jarrow Formulas Extra Strength Methyl B-12

This product is excellent. My mother has taken it for a long time. Previously, she experienced dizziness and blurred vision; however, she no longer suffers from these issues.

Vitamin B12 benefits thrombocytopenia

Bruise details

Khan MAN, Ghani U, Surani S, Aftab A. Vitamin B12 Deficiency, a Rare Cause of Isolated Thrombocytopenia in Adults. Cureus. 2023;15:e44162. doi:10.7759/cureus.44162

We examined the case of a 38-year-old male who experienced bruising and fatigue due to isolated thrombocytopenia, a condition marked by a low platelet count. This situation was particularly interesting because the underlying cause turned out to be a significant deficiency in vitamin B12, which is quite rare in adults when it comes to isolated thrombocytopenia. As we explored the case, we found that the patient's vitamin B12 levels were extraordinarily low, prompting treatment with subcutaneous mecobalamin, a form of vitamin B12.

After several doses, not only did the vitamin B12 levels increase, but so did the platelet count, contributing to the resolution of the bruising issue. This highlights the role that vitamin B12 can play in improving hematological health, specifically in cases of thrombocytopenia. Although the lack of hypersegmented neutrophils usually linked to vitamin B12 deficiency was noted, it emphasized the complex nature of diagnosing such conditions and the need for careful evaluation of symptoms and lab results.

Restored ferritin levels

Most Useful Review

My gynecologist prescribed B-12 due to dysbacteriosis and low ferritin, which caused fatigue and bruising under my eyes. This supplement helped raise my ferritin levels and alleviated all related symptoms. I chew the tablets as they take time to dissolve, and I find them quite pleasant to taste.

Updated: Mar 2026

Knee Pain details

I purchased this for my mother to help with her knee neuralgia.

Nausea details

B12 treatment effective for pancytopenia

Choi E, Galicia Garcia G, Kishore Anna K, Albuja Altamirano MF, Yip L, et al. Vitamin B12 Deficiency Manifesting As Pancytopenia, Lymphadenopathy, and Fever: A Clinical Mimic of Hematologic Malignancies. Cureus. 2024;16:e64676. doi:10.7759/cureus.64676

We observed how vitamin B12 deficiency can masquerade as serious conditions like hematologic malignancies, causing symptoms such as dizziness, nausea, and leukopenia. In our evaluation of a 39-year-old male, we found that treating severe B12 deficiency led to significant improvement in his blood counts.

After intensive vitamin B12 injections, his symptoms, including nausea, diminished, demonstrating the importance of assessing nutritional deficiencies before pursuing more invasive diagnoses. This case highlights how addressing vitamin B12 deficiency can effectively resolve challenging medical scenarios.

Effective relief

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69 people found this helpful

For two years, I endured severe esophageal spasms and indigestion daily. Nothing worked until I read about B-12 deficiency causing digestive issues—likely since I'd had my gallbladder removed. After trying this, I felt about 80% better within days, with continued improvement. My doctor scoffs at this, but after two years of torture, it has worked for me.

Updated: Mar 2026

Anxiety details

Vitamin B12 may reduce anxiety

Based on 12 Researches

Nahar M, Rai R, Jat D. Therapeutic intervention of vitamin B12 in mitigating chronic alcoholism induced alterations in adult zebrafish (): a holistic approach. Int J Neurosci. 2024. doi:10.1080/00207454.2024.2398564

We investigated the potential of vitamin B12 to mitigate anxiety in adult zebrafish subjected to chronic alcohol exposure. Our study involved exposing zebrafish to alcohol and then providing them with vitamin B12 to see if it would help reduce anxiety-related behaviors. By using a geotaxis test, we could observe how the fish responded in terms of anxiety in a controlled environment.

The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.

Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.

Improves anxiety response

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16 people found this helpful

With both ADHD and anxiety, I previously relied on meditation and meditation techniques. Upon reading about natural treatments for anxiety, I incorporated Methylcobalamin and Folinic Acid into my routine. The results have been remarkable; I haven't needed Xanax during the day, and my anxiety has significantly decreased. My husband, unaware of the supplements, has also noticed improved handling of daily stresses, which confirms their effectiveness.

Updated: Mar 2026

Autoimmune Disorder details

Pernicious anemia diagnosis and treatment

Based on 15 Researches

Mswelo VE, David MM, Banturaki A, Munyambalu DK, Hassan HA, et al. Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report. J Med Case Rep. 2025;19:60. doi:10.1186/s13256-025-05095-4

We examined a case of a 51-year-old Ugandan man who experienced recurring lower limb weakness linked to pernicious anemia, an autoimmune condition causing vitamin B12 deficiency. After initial treatments, his symptoms reappeared, leading to further testing that confirmed the diagnosis.

Treatment with vitamin B12 injections significantly improved his condition. This case emphasizes the need for healthcare providers to recognize the signs of vitamin B12 deficiency early, particularly in resource-limited settings, to ensure timely diagnosis and treatment.

Eliminated involuntary jerking

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22 people found this helpful

As a vegan, I suffered from involuntary finger jerking due to B12 deficiency. After starting these B12 supplements, the symptoms ceased immediately. It appears these tablets effectively address my deficiency since my diet hadn't changed.

Updated: Mar 2026

Diabetes details

Novel system lowers blood sugar

Based on 11 Researches

Zhou J, Ma H, Guan M, Feng J, Dong X, et al. Anti-inflammatory Fucoidan-ConA oral insulin nanosystems for smart blood glucose regulation. Int J Pharm. 2024;659:124250. doi:10.1016/j.ijpharm.2024.124250

We explored a novel oral delivery system using vitamin B12, fucoidan, and concanavalin A to enhance insulin effectiveness for diabetes management. This smart nanosystem targets inflammation while regulating blood glucose levels efficiently. Our findings indicated that when tested on type I diabetic mice, the nanosystem significantly lowered blood sugar and reduced inflammatory markers, such as TNF-α and interleukin-6. Notably, the system ensures safe and effective delivery, presenting a promising alternative to traditional insulin methods.

Supports diabetes management

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1 people found this helpful

I use it alongside diabetes management. I constantly take B12 as a separate supplement because it depletes when using diabetes pills long-term. This product is chewable and pleasant tasting, making it enjoyable to consume. I will surely repurchase.

Updated: Mar 2026

High Cholesterol details

White button mushrooms reduce cholesterol

Based on 10 Researches

Jeong SC, Jeong YT, Yang BK, Islam R, Koyyalamudi SR, et al. White button mushroom (Agaricus bisporus) lowers blood glucose and cholesterol levels in diabetic and hypercholesterolemic rats. Nutr Res. 2010;30:49. doi:10.1016/j.nutres.2009.12.003

We focused on whether white button mushrooms could help lower cholesterol levels and blood sugar in rats. In our study, we found that after three weeks of the mushroom powder, diabetic rats showed significant drops in glucose and triglyceride levels.

Furthermore, in hypercholesterolemic rats, a four-week treatment led to impressive reductions in total cholesterol and LDL cholesterol. Overall, these findings suggest that white button mushrooms may have beneficial effects on cholesterol and blood sugar management, at least in rat models.

Desired levels achieved

Most Useful Review

I purchased this for my parents, and after a month of use, both have reached the desired levels: my father at 670 and my mother exceeding the limit at 1138. I highly recommend this vitamin. The package was well done, offering good value for money. This is my first purchase, and it arrived in Brazil within a few days.

Updated: Apr 2025

Migraine details

Vitamin B12 deficiency and migraines

Based on 11 Researches

Abdelsadek SE, Tahoun SA, Mansour FM, Abdulsalam MF, Ahmed AM. The correlation between vitamin B12 serum levels and migraine: a case-control study. Neurol Res. 2025;47:195. doi:10.1080/01616412.2025.2462735

We examined the connection between vitamin B12 serum levels and migraine, both chronic and episodic. In our study, we compared two groups: 90 individuals suffering from migraines and 90 healthy participants. We measured the serum vitamin B12 levels of all subjects using a method known as enzyme-linked immunosorbent assay (ELISA).

Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.

This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.

Pain relief

Most Useful Review

After knee surgery, I was prescribed various painkillers, yet I still experienced a bad headache and ocular migraine. Upon discovering that some pain medications could elevate homocysteine levels, I took this supplement along with a B12 spray. Within 30 minutes, my headache dissipated.

Updated: Mar 2026

Neuropathy details

B12 treatment improves neuropathy symptoms

Based on 15 Researches

Dekker MJHJ, Heerdink GC, Plattel CHM. Vitamin B12 Deficiency-Induced Neuropathy and Cognitive and Motor Impairment in the Elderly: A Case Study. Food Nutr Bull. 2024;45:S53. doi:10.1177/03795721241226886

We explored the effects of vitamin B12 deficiency on neurological health in elderly patients. In a case study involving two patients, we observed that even with normal B12 levels, symptoms like fatigue and cognitive impairment persisted, especially in those with significant medical histories.

Treatment with hydroxocobalamin injections led to notable improvements in both patients’ cognitive and motor functions. This highlights the importance of recognizing vitamin B12 deficiency in older adults, even when traditional tests suggest adequate levels.

Reversed neuropathy

Most Useful Review

16 people found this helpful

Jarrow's methylcobalamin actually reversed the early stages of idiopathic peripheral neuropathy that I experienced. I continue to take it as insurance to this day. It is excellent and easy to take (sublingual).

Updated: Mar 2026

Ulcer details

Genetic insights into ulcer healing

Based on 6 Researches

Shah A, Khuba S, Kumar C S, Shanmukhaiah C, George M, et al. Phenotype puzzle: the role of novel LMBRD1 gene variant in Cbl deficiency causing Dyskeratosis Congenita-like clinical manifestations. J Hum Genet. 2025;70:207. doi:10.1038/s10038-025-01320-6

We delved into the complexities surrounding a specific genetic mutation in the LMBRD1 gene, which is linked to a variant form of cobalamin (vitamin B12) deficiency. This study highlighted a 15-year-old male with symptoms typical of Dyskeratosis Congenita, including skin hyperpigmentation and ulcers. After identifying a novel splice site deletion in the gene, we learned that this alteration can heavily impact vitamin B12 metabolism and lead to various clinical manifestations, including ulcers.

Importantly, we observed the effects of administering intravenous hydroxocobalamin therapy. Following treatment, our findings indicated a notable improvement in the patient's skin hyperpigmentation, angular cheilitis, and the painful aphthous ulcers. While the study primarily focused on genetic factors and treatment responses, the results suggested that vitamin B12 therapy plays a valuable role in alleviating ulcer symptoms. We encourage further exploration to expand our understanding of these relationships and optimize treatment approaches.

Effective treatment

Most Useful Review

B12 has been beneficial for my mouth ulcers.

Updated: Mar 2026

Autism details

Examining Vitamin B12 in Autism

Erden S, Akbaş İleri B, Sadıç Çelikkol Ç, Nalbant K, Kılınç İ, et al. Serum B12, homocysteine, and anti-parietal cell antibody levels in children with autism. Int J Psychiatry Clin Pract. 2022;26:8. doi:10.1080/13651501.2021.1906906

We conducted a study that examined the levels of vitamin B12, homocysteine, and anti-parietal cell antibodies in children diagnosed with autism spectrum disorder (ASD) compared to a control group. Our research included 69 children, where 36 had ASD, and 33 were matched controls based on age, sex, and socioeconomic status. The severity of autism was assessed using the Childhood Autism Rating Scale (CARS), while serum levels were measured using a common laboratory technique called enzyme-linked immunosorbent assay.

Our findings revealed that children with ASD had significantly lower levels of vitamin B12 and homocysteine compared to their peers in the control group. However, we found no significant difference in the levels of anti-parietal cell antibodies, which suggests that vitamin B12 deficiency may not be due to absorption issues related to these antibodies. While we observed notable micronutrient deficiencies, it’s important to clarify that the study did not establish a direct benefit of vitamin B12 treatment for autism symptoms.

Importantly, this research hints at the potential role that vitamin B12 deficiencies may play in the clinical features of autism. Nonetheless, we believe that further studies involving larger populations are necessary to better understand how these micronutrient levels might influence the condition and its underlying causes.

7.5

Increased focus

Most Useful Review

13 people found this helpful

For my child with autism, trying methyl-B12 injections and nasal sprays is advised by some online. However, this Jarrow lozenge seemed much easier and at 16.67% of the recommended daily dose for methyl-B12, I found it difficult to ascertain what benefits other methods could provide. I began giving my 10-year-old son about 1-2 lozenges per week, and he appears slightly more focused. I have also introduced some additional B vitamins, including Metafolin and B6, but I don't endorse mega doses; he takes them alternately at most. He also receives vitamin D and omega-3 supplements.

Updated: Mar 2026

Cold details

Vitamin B12 shows cold pain relief

Based on 3 Researches

Tamaddonfard E, Samadi F, Egdami K. The effects of vitamin B12 and diclofenac and their combination on cold and mechanical allodynia in a neuropathic pain model in rats. Vet Res Forum. 2013;4:19.

We explored the potential effects of vitamin B12 on cold sensitivity in a study using rats with induced neuropathic pain. The focus was to see whether vitamin B12, both alone and in combination with the pain reliever diclofenac, could alleviate cold and mechanical allodynia—a condition where non-painful stimuli are perceived as painful.

In our approach, we administered vitamin B12 in varying doses over ten consecutive days following nerve injury. What we discovered was quite telling. Higher doses of vitamin B12 (50, 100, and 200 µg kg(-1)) led to a reduction in cold sensitivity. However, when using a lower, subanalgesic dose (25 µg kg(-1)), vitamin B12 did not significantly impact pain responses when paired with low doses of diclofenac.

As we adjusted the vitamin B12 dosage to a more effective level (100 µg kg(-1)), we noticed an improvement in pain relief compared to diclofenac alone. These findings suggest that vitamin B12 could have a positive effect on alleviating cold-related pain in neuropathic conditions, especially when used at appropriate doses.

Strengthened immunity

Most Useful Review

7 people found this helpful

Great drug! My doctor, a neurologist, prescribed this to maintain my nervous system, which was vital as I found the noise in my ears very disturbing. I had to place the tablets in my mouth for quicker results. The small plates have a slightly sweet lemon flavour. I was pleased with its effectiveness; I didn't catch a cold this autumn, and my immunity was fortified. Joint mobility significantly increased, with no more crunching, and my sleep has improved. This vitamin helped stabilise my overall psychological state, and my nervous system is now fine. An excellent dietary supplement at a budget price!

Updated: Mar 2026

Hair Loss details

19 people found this helpful

One of the best supplements to increase energy and lower homocysteine! This B12, in the form of Methylcobalamin, from a great Jarrow brand, has worked perfectly for me. My blood tests revealed that my B12 levels, previously low, are now over 600 ng/mL. I combine it with Methyl Folate for better absorption. Since starting this protocol, I have noticed a significant reduction in hair loss, with real hair growth and a healthier appearance. My memory and mental clarity have also greatly improved. My doctor recommended I supplement with brewer’s yeast to maintain overall B vitamin levels. If my comment is helpful to you, please give a JOINHA (👍🏻).

Heart Attack details

Vitamin B12 shows no heart attack benefit

Likely Ineffective

Based on 2 Researches

Borowczyk K, Piechocka J, Głowacki R, Dhar I, Midtun Ø, et al. Urinary excretion of homocysteine thiolactone and the risk of acute myocardial infarction in coronary artery disease patients: the WENBIT trial. J Intern Med. 2019;285:232. doi:10.1111/joim.12834

In a recent study, we delved into the role of homocysteine thiolactone, a metabolite linked to heart disease, in predicting the risk of acute myocardial infarction (AMI). Conducted with a sizable group of 2049 patients suspected of having coronary artery disease (CAD), the trial was meticulously designed as a double-blind clinical intervention.

Participants were divided randomly into four distinct groups, receiving a combination of folic acid and other B vitamins or a placebo. Notably, we measured urinary levels of homocysteine thiolactone at different points throughout the study to draw correlations with heart attack incidents.

Our analysis revealed that while the homocysteine thiolactone/creatinine ratio was a significant predictor of AMI risk, there was no observable effect from the vitamin B treatments received by participants. This suggests that vitamin B12, when part of a group of B vitamins, did not independently influence the likelihood of having a heart attack.

Ultimately, we found that higher levels of homocysteine thiolactone correlated with a greater risk of AMI, but the combination of vitamin B treatments did not alter this outcome. This points to the potential of homocysteine thiolactone as an important marker in understanding cardiovascular health.

7.5

Enhances cardiovascular health

Most Useful Review

This supplement is beneficial for the nervous system and supports the brain and spinal cord. It helps the cardiovascular system by preventing thrombus formation, reducing the risk of atherosclerosis, heart attack, and stroke, while also normalising blood pressure.

Updated: Apr 2025

Hypothyroidism details

Vitamin B12 and hypothyroid patients

Likely Ineffective

Based on 4 Researches

Chatterjee T, Gupta R, Choudhary S. A Study on Vitamin B12 Levels in Hypothyroid Patients Presenting to a Tertiary Care Teaching Hospital. J Assoc Physicians India. 2023;71:1.

We explored the connection between vitamin B12 deficiency and hypothyroidism through a focused study involving 100 hypothyroid patients. This research took place over a year and aimed to determine how common vitamin B12 deficiency is among these individuals and how it correlates with thyroid antibodies.

Our findings revealed that a significant 68% of the hypothyroid patients were vitamin B12 deficient. Interestingly, a large majority of these deficient patients were female, specifically 73.5%. Additionally, we noted that a high percentage of patients with elevated Anti TPO and Anti Thyroglobulin antibodies also had low vitamin B12 levels.

Although vitamin B12 deficiency was present in a notable portion of the hypothyroid population, we're careful to point out that the study does not state that vitamin B12 supplementation alone can fully alleviate hypothyroid symptoms. However, it suggests that addressing this deficiency could be a valuable addition to current hypothyroid treatments. By recognizing and treating vitamin B12 deficiency, we may improve the overall management of hypothyroid conditions for some patients.

7.5

Enhanced mood

Most Useful Review

Remarkable for mood and energy, but be cautious of breakouts! I’ve tried numerous supplements and nothing has affected me this positively and quickly. This sublingual B12 has significantly improved my mood swings, energy, and concentration. I’m pleased to have tried it for my anaemia related to hypothyroidism. However, I may need to reduce the dosage due to hairline and back acne reactions caused by high B12 levels.

Updated: Apr 2025

Irritable Bowel Syndrome details

Dietary guidance aids IBS management

Mazzawi T, Hausken T, Gundersen D, El-Salhy M. Effects of dietary guidance on the symptoms, quality of life and habitual dietary intake of patients with irritable bowel syndrome. Mol Med Rep. 2013;8:845. doi:10.3892/mmr.2013.1565

We examined how dietary guidance affects irritable bowel syndrome (IBS) symptoms and quality of life, particularly focusing on vitamin B12 intake. Our study involved 46 patients diagnosed with IBS based on established criteria, with 17 completing the entire program.

Through three sessions of personalized dietary advice, each lasting about 45 minutes, we found a significant reduction in IBS symptoms after the patients implemented the dietary changes. Their quality of life scores also improved notably. Although we noted an increase in vitamin B12 intake, it's important to emphasize that we did not isolate its effects from those of other dietary changes.

Interestingly, while our guidance helped patients enhance their overall nutrient intake, including vitamins and minerals, the increase in vitamin B12 specifically was the only change that reached statistical significance. However, we found no substantial differences in overall caloric or macronutrient intake among the participants.

In conclusion, while dietary guidance showed promising benefits for managing IBS symptoms and overall life quality, the impact of vitamin B12 alone remains unclear, as other dietary modifications may have played a role. Our findings suggest that individualized dietary counseling is a viable option in IBS management.

7.5

Mental stability

Most Useful Review

9 people found this helpful

I find that taking B-12 helps with my symptoms. Although the taste is unusual, I feel mentally stable after ingestion. This supplement is quite effective for my irritable bowel syndrome, as it supports nerve function and repairs peripheral nerve damage.

Updated: Mar 2026

Leg Cramps details

5 people found this helpful

I recently discovered that I have the MTHFR C677T gene defect, leading to inefficient absorption of B12 and folate. I had chronic leg cramps for years, which I thought were hereditary. After adding this supplement, I've noticed significantly less cramping in my legs within a week. I appreciate the pleasant taste and plan to continue using it long-term.

Liver Disease details

Methylcobalamin aids liver health

Based on 10 Researches

Xu W, Wang Y, Cui S, Zheng Q, Lin Y, et al. Methylcobalamin protects against liver failure via engaging gasdermin E. Nat Commun. 2025;16:1233. doi:10.1038/s41467-024-54826-6

We explored how methylcobalamin, a form of vitamin B12, impacts liver disease, particularly in the context of cholestatic liver failure. The study utilized high-throughput screening to identify methylcobalamin as a specific inhibitor of gasdermin E (GSDME), a protein that plays a key role in pyroptotic cell death—a form of inflammatory cell death contributing to liver damage.

Our findings showed that when tested on mouse models with liver failure due to cholestasis, cisplatin, or concanavalin A, methylcobalamin effectively reduced liver damage. It significantly lowered liver transaminase levels, indicating less liver inflammation and cellular injury, and helped alleviate overall liver cell death.

Furthermore, methylcobalamin worked by preventing the cleavage of GSDME, which is essential for uncontrolled inflammatory cell death. By binding to a specific site on the GSDME protein, it blocked the interactions that trigger this damaging process. Overall, our study highlighted the potential of methylcobalamin as a promising therapeutic option for managing cholestatic liver failure and related conditions.

Memory improvement

Most Useful Review

1 people found this helpful

B12 greatly influences memory. After experiencing memory decline at 70, I had a blood test to check my B12 levels. I started chewing one tablet daily, and I’ve noticed significant improvement in my memory. My family also takes it, and it's genuinely helpful for maintaining cognitive function, especially concerning liver disease.

Updated: Apr 2025

Menopause details

Vitamin B12 may aid menopause relief

Likely Very Effective

Based on 2 Researches

Palacios S, Mustata C, Rizo JM, Regidor PA. Improvement in menopausal symptoms with a nutritional product containing evening primrose oil, hop extract, saffron, tryptophan, vitamins B6, D3, K2, B12, and B9. Eur Rev Med Pharmacol Sci. 2023;27:8180. doi:10.26355/eurrev_202309_33578

We observed the effects of a nutritional product that combined various ingredients, including vitamin B12, on menopausal symptoms. This study involved 156 menopausal women who took the product daily for 12 weeks and reported their symptoms using a validated scale.

After completing the study, we found significant reductions in various menopause-related issues. This included a substantial 45% decrease in depressive mood and a notable reduction of 48% in hot flashes. It's important to note that while vitamin B12 was included in the treatment, it was part of a broader combination with other beneficial ingredients.

However, we must clarify that the specific impact of vitamin B12 alone cannot be fully determined from this study. The results are promising for the product as a whole, showing effective relief from many menopausal symptoms, but further research is needed to isolate the role of vitamin B12 in managing these symptoms.

Better sleep

Most Useful Review

Great product. I sleep better after taking it. It helps stabilise my autonomic nervous system during menopause. The quality is very good and the price is reasonable.

Updated: Mar 2026

Reflux details

Nice! It tastes alright and seems strong enough while dissolving well without aggravating my reflux. I took this to help elevate my blood platelets, an issue from chemotherapy. I'm impressed with the quality, especially for the price.

Swollen Lymph Nodes details

Swelling reduced quickly

This highly digestible form of B12 is superb in taste and acts quickly. The swelling on my tongue, which was a symptom of B12 deficiency, disappeared in just five days. It’s essential for vegetarians like myself.

Celiac details

Life-changing formula

Gluten-free methyl-B12 Jarrow's methyl-B12 formulations have completely transformed my life. I would advise against taking cyanocobalamin! These gluten-free formulations are fantastic for individuals with celiac disease.

Depression details

Vitamin B affects depression risk

Based on 21 Researches

Laird EJ, O'Halloran AM, Molloy AM, Healy M, Hernandez B, et al. Low vitamin B but not folate is associated with incident depressive symptoms in community-dwelling older adults: a 4-year longitudinal study. Br J Nutr. 2023;130:268. doi:10.1017/S0007114521004748

We explored the connection between vitamin B levels and depression in older adults over four years. Our study followed nearly 3,850 participants and found that those with low blood levels of vitamin B were significantly more likely to report depressive symptoms. Specifically, individuals with low vitamin B had a 51% higher chance of developing depression compared to those with adequate levels.

However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults.

Boosts energy levels

Most Useful Review

4 people found this helpful

Methylcobalamin is exceptional! Within a month, it transformed my daughter's appetite and energy, allowing for normal conversations. I’m surprised at the swift improvement in her mood and behaviour.

Updated: Mar 2026

Flu details

I take B12 as part of an immune boost to help prevent shingles, as my mother suffered severely. After researching ways to boost my immune system, I found this combination. Since starting it, I haven't been ill once, not even with colds or the flu. I intend to continue using this immune support regimen to ward off sickness, including shingles.

The taste is easy! It dissolves slowly, but I have been in a relatively good mood during my premenstrual syndrome. Thank you!!

Premenstrual Syndrome details

Stroke details

Vitamin B12 aids stroke recovery

Based on 16 Researches

Ge Y, Yang C, Zadeh M, Sprague SM, Lin YD, et al. Functional regulation of microglia by vitamin B12 alleviates ischemic stroke-induced neuroinflammation in mice. iScience. 2024;27:109480. doi:10.1016/j.isci.2024.109480

We explored the role of vitamin B12 in managing neuroinflammation after an ischemic stroke. Through preclinical studies, we observed that vitamin B12 effectively influenced microglial cells, which are key to the brain's immune response. This treatment promoted important cellular processes, leading to reduced brain damage and better neurological outcomes. However, when microglia were depleted before stroke, the positive effects of vitamin B12 disappeared. Overall, while vitamin B12 shows promise in enhancing recovery post-stroke, its impact hinges on these immune cells.

7.5

Reduces stroke risk

Most Useful Review

2 people found this helpful

This complex is truly wonderful, containing essential B vitamins (B12, B6, B9) in their active forms. They assist with chronic viral loads and lower homocysteine levels, consequently reducing the risk of cardiovascular diseases, particularly stroke. This complex is vital for the elderly who are at risk.

Updated: Mar 2026

Attention Deficit Hyperactivity Disorder details

Significant symptom relief

Vitamin B12 (methylcobalamin) offers neuroprotective and immunomodulatory benefits. It's chewable, dissolving quickly when chewed. I’ve noticed considerable improvement in symptoms like shortness of breath, tremors, fatigue, anxiety, and sadness. If you find my comment useful, I’d be delighted. Health to all!

Chronic Fatigue Syndrome details

Vitamin B12 ineffective for CFS

Wiebe E. N of 1 trials. Managing patients with chronic fatigue syndrome: two case reports. Can Fam Physician. 1996;42:2214.

We explored the effectiveness of high-dose vitamin B12 injections on chronic fatigue syndrome (CFS) through two case reports that utilized N of 1 trials. This approach allowed us to make tailored treatment decisions based on individual responses to the therapy.

In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.

These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.

Reduced fatigue

Most Useful Review

99 people found this helpful

Good vitamins; as recommended by my doctor for the nervous system and reducing fatigue, they accomplished just that. I highly recommend purchasing them.

Updated: Mar 2026

Dizziness details

B12 treatment improved dizziness symptoms

Based on 17 Researches

Cittolin-Santos GF, Khalil S, Bakos JK, Baker K. Chronic Atrophic Gastritis with Negative Intrinsic Factor and Parietal Cell Antibody Presenting as a Severe Hemolytic Anemia. Case Rep Hematol. 2020;2020:8697493. doi:10.1155/2020/8697493

We examined a unique case involving a 28-year-old male who experienced dizziness related to severe anemia from low vitamin B12 levels.

After treatment with daily vitamin B12 injections, his symptoms and lab values significantly improved, indicating a positive response to the treatment.

Despite the rare nature of his condition—seronegative pernicious anemia—the results suggest that B12 can effectively alleviate dizziness stemming from anemia in similar cases.

High-quality supplement

Most Useful Review

I’ve previously reviewed another Jarrow Formulas product, which was excellent. This individual formula is equally effective for improving my B12 levels and alleviating dizziness. The bioavailable form of B12 works wonders.

Updated: Mar 2026

Frozen Shoulder details

Eased shoulder stiffness

4 people found this helpful

I bought it in April 2021 and noticed a significant improvement in my stiff shoulders after taking one tablet before bed. I’ve found that when I pay attention to my posture, my shoulders feel more relaxed. The tablet is lemon-flavoured and quite pleasant, making it easy to recommend.

Back Pain details

B12 alleviates low back pain

Based on 17 Researches

Mauro GL, Martorana U, Cataldo P, Brancato G, Letizia G. Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study. Eur Rev Med Pharmacol Sci. 2000;4:53.

We evaluated the effectiveness of intramuscular vitamin B12 in treating low back pain among 60 patients aged 18 to 65 with mechanical pain lasting at least six months.

In this double-blind, placebo-controlled study, both groups showed improvement in pain levels. However, those receiving B12 had a more significant reduction in pain and dependence on pain medication compared to the placebo group.

Overall, B12 appears to be a safe option for alleviating low back pain, helping to reduce discomfort and medication use for those without nutritional deficiencies.

Reduced foot pain

Most Useful Review

2 people found this helpful

I initially tried B12 for Morton's neuroma, and it worked wonders. I've noticed a significant reduction in foot pain and regained feeling in areas that had been numb for quite some time, highlighting the importance of B12.

Updated: Apr 2025

Insomnia details

Vitamin B12 promotes sleep in rats

Chang HY, Sei H, Morita Y. Effects of intravenously administered vitamin B12 on sleep in the rat. Physiol Behav. 1995;57:1019.

We sought to determine the impact of vitamin B12 (VB12) on sleep patterns in rats, particularly considering its potential benefits for those struggling with insomnia. By giving rats a daily intravenous dose of VB12, we monitored their sleep using polysomnographic recordings over a four-day period.

During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.

Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.

Helplessness lifted

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2 people found this helpful

I struggled daily with insomnia until I found this product. Now, I feel sleepy, and my eyes appear brighter and less tired each morning.

Updated: Mar 2026

Shingles details

Meta-analysis confirms B12 reduces shingles nerve pain

Based on 8 Researches

Wang JY, Wu YH, Liu SJ, Lin YS, Lu PH. Vitamin B12 for herpetic neuralgia: A meta-analysis of randomised controlled trials. Complement Ther Med. 2018;41:277. doi:10.1016/j.ctim.2018.10.014

Researchers analyzed four randomized controlled trials involving 383 participants to determine whether vitamin B12 could help relieve postherpetic neuralgia (PHN)—the painful nerve condition that sometimes follows shingles. The results were encouraging: patients receiving B12 experienced significantly greater pain reduction compared to those taking placebo, with improvements also seen in quality of life and reduced need for pain medications.

While these findings suggest B12 could serve as a valuable complementary treatment for PHN, the researchers emphasized that more research is needed before making definitive clinical recommendations.

Nerve repair

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8 people found this helpful

Methyl cobalamin is essential to take for at least a week when shingles occur. It's the only substance that repairs nerve coverings, and I keep some on hand. It works as effectively as a B12 injection, at a mere ten pence per dose.

Updated: Apr 2026

Tinnitus details

No significant benefit from B12

Dadgarnia M, Mandegari M, Zand V, Vaziribozorg S, Zare-Zardini H, et al. The effect of vitamin B12 on idiopathic tinnitus. Am J Otolaryngol. 2024;45:104028. doi:10.1016/j.amjoto.2023.104028

We conducted a double-blind clinical trial with 140 patients suffering from idiopathic tinnitus to gauge the effectiveness of vitamin B12. Participants were divided into two groups, one receiving vitamin B12 and the other a placebo over a month.

We evaluated tinnitus severity through questionnaires at multiple intervals. However, our findings revealed that vitamin B12 did not significantly reduce tinnitus severity compared to the placebo.

Ultimately, our study suggests that vitamin B12 may not be a beneficial treatment for tinnitus, as the results showed no noteworthy improvements.

7.5

Improved focus

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5 people found this helpful

It works well! I find this vitamin B12 supplement helps with my tinnitus, neck, and intercostal neuralgia. Other B12 products did not work for me, but this one is exceptional, especially as it's in a ramune type, making it easy to take. The large tablet forms are difficult for me. It refreshes my head, relieving neck stiffness and associated tinnitus. I recommend it for migraine sufferers as well and hope they create more ramune type vitamin B supplements.

Updated: Mar 2026

Sleep Apnea details

Improved sleep quality

4 people found this helpful

I confirm the result! I suffer from insomnia, feeling constantly fatigued after sleep since having my child. Initially, I saw no improvement from the tablets, but persevered. Once I persisted, I found these vitamins incredibly effective: I now fall asleep faster and remain more cheerful after waking. For anyone struggling with sleep issues, particularly fellow mothers, I wholeheartedly recommend this.

Anemia details

Effectiveness of B12 in IGS

Based on 21 Researches

Di Sario F, Piloni F, Gasparini F, Serpetti E, Bruschi B, et al. Severe pancytopenia at the presentation of Imerslund-Gräsbeck syndrome in a 23-month-old Italian boy. Ital J Pediatr. 2024;50:186. doi:10.1186/s13052-024-01759-x

We explored the case of a 23-month-old boy suffering from severe pancytopenia linked to Imerslund-Gräsbeck syndrome, a rare condition caused by an inability to absorb vitamin B12. Upon diagnosis, the boy received vitamin B12 replacement therapy, which effectively addressed his symptoms and improved his health.

This case highlights the significance of early detection and treatment of IGS to avoid potential neurological damage. It's crucial to recognize this condition, even when neurological symptoms are absent, to provide timely care.

No more anaemia

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14 people found this helpful

This vitamin is excellent and easily digested. Since I started taking it, I no longer have anaemia, as confirmed by my tests.

Updated: Mar 2026

Constipation details

Prevents constipation

This product is very nice. It helps my muscles and reduces fatigue. The clean ingredients do not lead to constipation, and it tastes excellent. It is also beneficial for the nervous system.

Essential for vegetarians

Mild Cognitive Impairment details

Methyl vitamin B12 is excellent for reducing homocysteine levels, helping prevent atherosclerosis and Mild Cognitive Impairment. It's particularly crucial for vegetarians, who may struggle to obtain sufficient B12 from their diet. I highly recommend it due to its affordability and effectiveness.

Headache details

Vitamin B12 deficiency linked to migraines

Based on 9 Researches

We conducted a case-control study to investigate the link between vitamin B12 serum levels and migraine, which affects so many people but lacks a fully understood cause. Our research included 90 individuals experiencing migraines—split into those with chronic migraines and those with episodic migraines—matched against 90 healthy participants.

We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.

Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.

7.5

Effective for headaches

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7 people found this helpful

Wonderful effect! My spirit is stable, and it has also helped with shoulder stiffness, muscle fatigue, and headaches from eye strain. The effectiveness at this price is truly amazing!

Updated: Apr 2026

Acne details