Last update
5/28/2026
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.2
USERS' SCORE
Medium or Average
Based on 12 Reviews
6.7
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B₁₂ (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
8
We conducted a case-control study to investigate the link between vitamin B12 serum levels and migraine, which affects so many people but lacks a fully understood cause. Our research included 90 individuals experiencing migraines—split into those with chronic migraines and those with episodic migraines—matched against 90 healthy participants.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
Read More
8
We evaluated whether B vitamins, particularly B1, B6, B12, and B9, could help reduce migraine headaches in women. This rigorous double-blind, placebo-controlled study involved 120 participants who took these vitamins or a placebo for 12 weeks.
The results showed notable improvements for those taking the B vitamins, including fewer headache attacks and reduced need for medication. However, while these findings are promising, further research with larger groups and longer follow-ups is necessary to verify the effects.
The results showed notable improvements for those taking the B vitamins, including fewer headache attacks and reduced need for medication. However, while these findings are promising, further research with larger groups and longer follow-ups is necessary to verify the effects.
Read More
7
Cerebral venous thrombosis and treatment
We explored the case of a 25-year-old man who came to the hospital with severe headaches and dizziness. Following a diagnosis of cerebral venous thrombosis, linked to his vitamin B12 deficiency from nitrous oxide use, he received treatment that included vitamin B12 supplements.
After a week of therapy, both his headaches and vision issues notably improved, allowing for discharge. This case suggests vitamin B12 could be a helpful part of treating headaches associated with specific deficiencies.
After a week of therapy, both his headaches and vision issues notably improved, allowing for discharge. This case suggests vitamin B12 could be a helpful part of treating headaches associated with specific deficiencies.
Read More
Most Useful Reviews
7.5
Effective for headaches
7 people found this helpful
Wonderful effect! My spirit is stable, and it has also helped with shoulder stiffness, muscle fatigue, and headaches from eye strain. The effectiveness at this price is truly amazing!
Read More
9
Headaches reduced dramatically
2 people found this helpful
I found this tool very effective, particularly for those who suffer from headaches due to weather changes. After taking it for two weeks, I realised I hadn’t experienced any headaches. It’s convenient to take just one tablet, and it’s economical enough for the whole family.
Read More
9
Relieved headaches
2 people found this helpful
A good vitamin that I took to improve mental clarity—it actually works. My mother suffers from longstanding headaches, and she is thrilled with the results. No doctor has provided anything remotely similar!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.2
- All Researches
9
We investigated a unique case where a 14-year-old girl experienced prolonged headaches and nausea due to cerebral venous thrombosis linked to a rare genetic mutation. Elevated homocysteine levels were discovered during examinations, leading to anticoagulation therapy.
Notably, after receiving additional vitamins like B12, the patient reported no headaches within a month, alongside a significant decrease in intracranial pressure and thrombosis size. Although the treatment context is specialized, this case emphasizes the importance of understanding genetic factors in headache disorders.
Notably, after receiving additional vitamins like B12, the patient reported no headaches within a month, alongside a significant decrease in intracranial pressure and thrombosis size. Although the treatment context is specialized, this case emphasizes the importance of understanding genetic factors in headache disorders.
Read More
8
We evaluated whether B vitamins, particularly B1, B6, B12, and B9, could help reduce migraine headaches in women. This rigorous double-blind, placebo-controlled study involved 120 participants who took these vitamins or a placebo for 12 weeks.
The results showed notable improvements for those taking the B vitamins, including fewer headache attacks and reduced need for medication. However, while these findings are promising, further research with larger groups and longer follow-ups is necessary to verify the effects.
The results showed notable improvements for those taking the B vitamins, including fewer headache attacks and reduced need for medication. However, while these findings are promising, further research with larger groups and longer follow-ups is necessary to verify the effects.
Read More
8
We conducted a case-control study to investigate the link between vitamin B12 serum levels and migraine, which affects so many people but lacks a fully understood cause. Our research included 90 individuals experiencing migraines—split into those with chronic migraines and those with episodic migraines—matched against 90 healthy participants.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
Read More
7
Cerebral venous thrombosis and treatment
We explored the case of a 25-year-old man who came to the hospital with severe headaches and dizziness. Following a diagnosis of cerebral venous thrombosis, linked to his vitamin B12 deficiency from nitrous oxide use, he received treatment that included vitamin B12 supplements.
After a week of therapy, both his headaches and vision issues notably improved, allowing for discharge. This case suggests vitamin B12 could be a helpful part of treating headaches associated with specific deficiencies.
After a week of therapy, both his headaches and vision issues notably improved, allowing for discharge. This case suggests vitamin B12 could be a helpful part of treating headaches associated with specific deficiencies.
Read More
7
We investigated the prevalence and impact of vitamin B12 deficiency in a diverse group of patients at a tertiary care hospital. With a focus on individuals aged 50 to 65, particularly strict vegetarians, we found that many suffered from significant symptoms, including headache.
Among the 220 cases studied, 95% reported head heaviness or headaches as a psychiatric manifestation, showcasing the importance of recognizing vitamin B12 deficiency. Early detection and treatment can reverse most related disorders, highlighting the need for greater awareness in clinical settings.
Among the 220 cases studied, 95% reported head heaviness or headaches as a psychiatric manifestation, showcasing the importance of recognizing vitamin B12 deficiency. Early detection and treatment can reverse most related disorders, highlighting the need for greater awareness in clinical settings.
Read More
User Reviews
USERS' SCORE
Medium or Average
Based on 12 Reviews
6.7
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Effective for headaches
7 people found this helpful
Wonderful effect! My spirit is stable, and it has also helped with shoulder stiffness, muscle fatigue, and headaches from eye strain. The effectiveness at this price is truly amazing!
Read More
9
Headaches reduced dramatically
2 people found this helpful
I found this tool very effective, particularly for those who suffer from headaches due to weather changes. After taking it for two weeks, I realised I hadn’t experienced any headaches. It’s convenient to take just one tablet, and it’s economical enough for the whole family.
Read More
9
Relieved headaches
2 people found this helpful
A good vitamin that I took to improve mental clarity—it actually works. My mother suffers from longstanding headaches, and she is thrilled with the results. No doctor has provided anything remotely similar!
Read More
9
Headaches gone
2 people found this helpful
I used it alongside magnesium, and it improved my focus and calmness. Tinnitus has decreased, hand numbness is less, and headaches have disappeared. I also experienced a significant reduction in stomach pain. Ongoing treatment is proving beneficial.
Read More
9
Headache elimination
This product tastes great and is reasonably priced. I often struggle with low B12 levels as a vegetarian, but this B12 eliminates my headaches and boosts my energy within days.
Read More
Frequently Asked Questions
9
Headaches reduced dramatically
2 people found this helpful
I found this tool very effective, particularly for those who suffer from headaches due to weather changes. After taking it for two weeks, I realised I hadn’t experienced any headaches. It’s convenient to take just one tablet, and it’s economical enough for the whole family.
0
Worsened headaches
5 people found this helpful
Do not go!!! After a week, she stopped taking it due to frequent headaches that she hadn’t experienced before. Upon discontinuation, the pain did lessen. When I tried to restart, it was the same story. It's a shame.
9
Headache elimination
This product tastes great and is reasonably priced. I often struggle with low B12 levels as a vegetarian, but this B12 eliminates my headaches and boosts my energy within days.
9
Relieved headaches
2 people found this helpful
A good vitamin that I took to improve mental clarity—it actually works. My mother suffers from longstanding headaches, and she is thrilled with the results. No doctor has provided anything remotely similar!
0
Instant headache
It gave me a headache straight away.
7.5
Less headache pain
9 people found this helpful
I really enjoyed these tasty vitamins, taking them along with other B vitamins at different times. I’ve noticed that my headaches have lessened significantly since using them. I used to buy a mixed complex but now choose only the most beneficial ones for my relief.
7.5
Effective for headaches
7 people found this helpful
Wonderful effect! My spirit is stable, and it has also helped with shoulder stiffness, muscle fatigue, and headaches from eye strain. The effectiveness at this price is truly amazing!
0
Severe headache reaction
1 people found this helpful
Do not consume B12 without folic acid! I experienced an awful headache that made me unable to eat, leading me to discard it entirely. The sweet lemon flavour was pleasant, making it easy to consume.
0
Caused headaches
I didn’t like the product at all, as it caused me headaches and dizziness about an hour after taking it. I tried reducing the dose but still experienced the same issue. I won’t be purchasing it again.
7
Cerebral venous thrombosis and treatment
We explored the case of a 25-year-old man who came to the hospital with severe headaches and dizziness. Following a diagnosis of cerebral venous thrombosis, linked to his vitamin B12 deficiency from nitrous oxide use, he received treatment that included vitamin B12 supplements.
After a week of therapy, both his headaches and vision issues notably improved, allowing for discharge. This case suggests vitamin B12 could be a helpful part of treating headaches associated with specific deficiencies.
After a week of therapy, both his headaches and vision issues notably improved, allowing for discharge. This case suggests vitamin B12 could be a helpful part of treating headaches associated with specific deficiencies.
7
We investigated the prevalence and impact of vitamin B12 deficiency in a diverse group of patients at a tertiary care hospital. With a focus on individuals aged 50 to 65, particularly strict vegetarians, we found that many suffered from significant symptoms, including headache.
Among the 220 cases studied, 95% reported head heaviness or headaches as a psychiatric manifestation, showcasing the importance of recognizing vitamin B12 deficiency. Early detection and treatment can reverse most related disorders, highlighting the need for greater awareness in clinical settings.
Among the 220 cases studied, 95% reported head heaviness or headaches as a psychiatric manifestation, showcasing the importance of recognizing vitamin B12 deficiency. Early detection and treatment can reverse most related disorders, highlighting the need for greater awareness in clinical settings.
8
We evaluated whether B vitamins, particularly B1, B6, B12, and B9, could help reduce migraine headaches in women. This rigorous double-blind, placebo-controlled study involved 120 participants who took these vitamins or a placebo for 12 weeks.
The results showed notable improvements for those taking the B vitamins, including fewer headache attacks and reduced need for medication. However, while these findings are promising, further research with larger groups and longer follow-ups is necessary to verify the effects.
The results showed notable improvements for those taking the B vitamins, including fewer headache attacks and reduced need for medication. However, while these findings are promising, further research with larger groups and longer follow-ups is necessary to verify the effects.
8
We conducted a case-control study to investigate the link between vitamin B12 serum levels and migraine, which affects so many people but lacks a fully understood cause. Our research included 90 individuals experiencing migraines—split into those with chronic migraines and those with episodic migraines—matched against 90 healthy participants.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
5
We evaluated the connection between vitamin B12 levels and migraines in our case-control study involving 70 migraine patients and 70 healthy individuals.
Our findings revealed that migraine sufferers had notably lower levels of B12 and higher levels of methylmalonic acid (MMA). Interestingly, those with the highest B12 levels had a significantly reduced risk of experiencing migraines, while higher MMA levels corresponded with an increased migraine risk.
However, there was no clear link between these vitamin levels and specific headache characteristics. Overall, while B12 deficiency might be associated with migraines, it doesn't seem to directly affect headache traits.
Our findings revealed that migraine sufferers had notably lower levels of B12 and higher levels of methylmalonic acid (MMA). Interestingly, those with the highest B12 levels had a significantly reduced risk of experiencing migraines, while higher MMA levels corresponded with an increased migraine risk.
However, there was no clear link between these vitamin levels and specific headache characteristics. Overall, while B12 deficiency might be associated with migraines, it doesn't seem to directly affect headache traits.
References
- Zhang M, Shi B, Zhao M. Cerebral venous thrombosis with hyperhomocysteinemia due to loss of heterozygosity at methylenetetrahydrofolate reductase (MTHFR) locus: a case report. BMC Neurol. 2023;23:154. 10.1186/s12883-023-03200-y
- Lin SS, Fan IW, Chen CY, Su YJ. A nitrous oxide abuser presenting with cerebral venous thrombosis: A case report. Med Int (Lond). 2022;2:20. 10.3892/mi.2022.45
- Singh J, Dinkar A, Gupta P, Atam V. Vitamin B12 deficiency in northern India tertiary care: Prevalence, risk factors and clinical characteristics. J Family Med Prim Care. 2022;11:2381. 10.4103/jfmpc.jfmpc_650_21
- Nematgorgani S, Razeghi-Jahromi S, Jafari E, Togha M, Rafiee P, et al. B vitamins and their combination could reduce migraine headaches: A randomized double-blind controlled trial. Curr J Neurol. 2022;21:105. 10.18502/cjn.v21i2.10494
- Arıcan P, Bozkurt O, Cavusoglu D, Gencpınar P, Haspolat S, et al. Various Neurological Symptoms with Vitamin B12 Deficiency and Posttreatment Evaluation. J Pediatr Neurosci. 2020;15:365. 10.4103/jpn.JPN_130_19
- Liampas IN, Siokas V, Aloizou AM, Tsouris Z, Dastamani M, et al. Pyridoxine, folate and cobalamin for migraine: A systematic review. Acta Neurol Scand. 2020;142:108. 10.1111/ane.13251
- Togha M, Razeghi Jahromi S, Ghorbani Z, Martami F, Seifishahpar M. Serum Vitamin B12 and Methylmalonic Acid Status in Migraineurs: A Case-Control Study. Headache. 2019;59:1492. 10.1111/head.13618
- Maruyama S, Yanaka K, Saura M, Takahashi T, Aiyama H, et al. Preventable cerebral venous sinus thrombosis from diet- and alcohol-induced hyperhomocysteinemia: illustrative case. J Neurosurg Case Lessons. 2026;11. 10.3171/CASE25759
- Abdelsadek SE, Tahoun SA, Mansour FM, Abdulsalam MF, Ahmed AM. The correlation between vitamin B12 serum levels and migraine: a case-control study. Neurol Res. 2025;47:195. 10.1080/01616412.2025.2462735
