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Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B6 (as Pyridoxal-5-Phosphate)
1.5 mg
88%
Folate (400 mcg as (6S)-5-MTHF [from (6S)-5-Methyltetrahydrofolate Glucosamine Salt])
680 mcg DFE‡
170%
Vitamin B12 (as Methylcobalamin)
1,000 mcg
41,667%
The product is found useful for the following medical conditions
Anemia
SCIENTIFIC SCORE
Moderately Effective
Based on 32 Researches
8
USERS' SCORE
Good
Based on 53 Reviews
8.8
9.5
Vitamin B6 improves anemia outcomes
Recurrent sideroblastic anemia during pregnancy.
Most Relevant Research
We observed a compelling case involving a 32-year-old pregnant woman who experienced severe anemia during her pregnancy. This specific type of anemia, known as sideroblastic anemia, is quite rare in expectant mothers. The patient had been feeling weak and had heart palpitations for two weeks when she came to the emergency room.
Testing revealed she had an alarming hemoglobin level of just 4.2 g/dl, indicating severe anemia, along with a notably low reticulocyte count. What made this case particularly interesting was her history of recurrent anemia, which occurred exclusively during her pregnancies.
Upon examining her bone marrow, doctors found numerous ring sideroblasts, which confirmed the diagnosis of sideroblastic anemia. Further investigation uncovered extremely low levels of pyridoxine, or vitamin B6, in her system. After administering vitamin B6 replacement therapy, her hemoglobin levels improved significantly without the need for blood transfusions, highlighting the vitamin’s role in managing this type of anemia during pregnancy.
Testing revealed she had an alarming hemoglobin level of just 4.2 g/dl, indicating severe anemia, along with a notably low reticulocyte count. What made this case particularly interesting was her history of recurrent anemia, which occurred exclusively during her pregnancies.
Upon examining her bone marrow, doctors found numerous ring sideroblasts, which confirmed the diagnosis of sideroblastic anemia. Further investigation uncovered extremely low levels of pyridoxine, or vitamin B6, in her system. After administering vitamin B6 replacement therapy, her hemoglobin levels improved significantly without the need for blood transfusions, highlighting the vitamin’s role in managing this type of anemia during pregnancy.
8.8
Supports energy production
Most Useful Review
Excellent composition! I take these vitamins daily, finding them delicious and effective against anaemia. They support energy and biochemical processes. I highly recommend them, especially since they're hard to find elsewhere.
Blood Clot
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.9
USERS' SCORE
Good
Based on 11 Reviews
8.8
9
Folic acid impacts blood clotting
Folic acid targets splenic extramedullary hemopoiesis to attenuate carbon black-induced coagulation-thrombosis potential.
Most Relevant Research
We investigated how folic acid affects blood clotting, particularly when exposed to carbon black (CB), a common industrial substance. In our study with adult C57BL/6 mice, we found that prolonged exposure to CB led to increased blood clotting potential due to changes in the spleen, where extra blood cell production occurs.
Notably, we observed that CB exposure caused an increase in certain cells responsible for blood clotting, while decreasing folic acid levels in the bloodstream. This drop in folic acid seemed to correlate with heightened levels of prostaglandin E2, a compound that can drive inflammation and increase blood clotting.
When we supplemented the mice with folic acid, we noted a reduction in the negative effects of CB on blood clotting. This protective effect appeared to stem from folic acid's ability to inhibit the enzymes involved in the excessive production of prostaglandins by splenic macrophages. Overall, our findings suggest that folic acid supplementation could be a valuable strategy to mitigate the heightened risk of thrombosis associated with carbon black exposure.
Notably, we observed that CB exposure caused an increase in certain cells responsible for blood clotting, while decreasing folic acid levels in the bloodstream. This drop in folic acid seemed to correlate with heightened levels of prostaglandin E2, a compound that can drive inflammation and increase blood clotting.
When we supplemented the mice with folic acid, we noted a reduction in the negative effects of CB on blood clotting. This protective effect appeared to stem from folic acid's ability to inhibit the enzymes involved in the excessive production of prostaglandins by splenic macrophages. Overall, our findings suggest that folic acid supplementation could be a valuable strategy to mitigate the heightened risk of thrombosis associated with carbon black exposure.
9.5
Reduced blood clot
Most Useful Review
I switched to this more affordable complex to lower my homocysteine, which is harmful to blood vessels and can cause blood clots. After taking it, my levels went down from 9.3 to 5.5. I'll continue using it, particularly since it’s essential for girls planning pregnancy.
Heart Attack
SCIENTIFIC SCORE
Questionable
Based on 15 Researches
6.2
USERS' SCORE
Good
Based on 8 Reviews
8.8
9
Vitamin B6 aids heart recovery
Vitamin B6 allosterically activates AMPK to promote postischemic angiogenesis in mice.
Most Relevant Research
We explored the potential of vitamin B6 (VB6) in promoting recovery after heart attacks, specifically its role in angiogenesis, which is the formation of new blood vessels. The study aimed to determine whether VB6 could help prevent cardiac dysfunction following acute myocardial infarction (AMI).
To assess the effects of VB6, we conducted both in vitro experiments, examining endothelial cell behavior, and in vivo tests using mice with heart attacks. We discovered that VB6 significantly enhanced cell migration and tubule formation in human umbilical vein endothelial cells, which are critical for blood vessel formation. This process was linked to increased activity of a protein called AMP-activated protein kinase (AMPK).
Interestingly, our findings showed that these beneficial effects of VB6 were reversed when we introduced AMPK inhibitors. This leads us to conclude that VB6 promotes heart recovery by activating AMPK, which in turn supports angiogenesis following AMI. In practical terms, long-term VB6 supplementation after heart attacks led to improved heart function and increased new blood vessel formation in mice, making this vitamin a promising candidate for heart recovery therapies.
To assess the effects of VB6, we conducted both in vitro experiments, examining endothelial cell behavior, and in vivo tests using mice with heart attacks. We discovered that VB6 significantly enhanced cell migration and tubule formation in human umbilical vein endothelial cells, which are critical for blood vessel formation. This process was linked to increased activity of a protein called AMP-activated protein kinase (AMPK).
Interestingly, our findings showed that these beneficial effects of VB6 were reversed when we introduced AMPK inhibitors. This leads us to conclude that VB6 promotes heart recovery by activating AMPK, which in turn supports angiogenesis following AMI. In practical terms, long-term VB6 supplementation after heart attacks led to improved heart function and increased new blood vessel formation in mice, making this vitamin a promising candidate for heart recovery therapies.
9.5
Homocysteine reduction
Most Useful Review
Does it really work? I took this to lower my homocysteine, which can damage blood vessels and increase the risk of heart attack. My levels dropped from 9.3 to 5.5, which is excellent. It's essential for women planning to conceive, though not all doctors mention it.
Heart Disease
SCIENTIFIC SCORE
Moderately Effective
Based on 25 Researches
8
USERS' SCORE
Good
Based on 16 Reviews
8.8
9
Folic acid reduces CHD risk
Association of maternal folic acid supplementation and offspring MTRR gene polymorphism with congenital heart disease: a hospital-based case-control study in Han population.
Most Relevant Research
We conducted a case-control study to look into how maternal folic acid supplementation affects the risk of congenital heart disease (CHD) in children and whether genetic factors, specifically MTRR gene polymorphisms, play a role in this relationship.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
9.5
Heart health improvements
Most Useful Review
Finding this supplement was a revelation; it combines active folic acid and B12 in a sublingual form, helping absorption and potentially lowering heart disease risks. I noticed a lift in mood and energy shortly after taking it. The slight chemical sweet taste is the only downside for me.
High Cholesterol
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.7
USERS' SCORE
Good
Based on 18 Reviews
8.8
9
Vitamin B6 reduces cholesterol levels
Antihyperlipidemic and Hepatoprotective Properties of Vitamin B6 Supplementation in Rats with High-Fat Diet-Induced Hyperlipidemia.
Most Relevant Research
We aimed to understand how Vitamin B6 influences high cholesterol levels, particularly through its effects on lipid metabolism in rats induced by a high-fat diet. To set the stage for our exploration, we used male Sprague-Dawley rats and placed them on this fat-rich diet for two weeks to establish a hyperlipidemia model.
We then supplied two groups of rats with varying doses of Vitamin B6—2.00 mg/kg and 3.00 mg/kg daily over the next eight weeks. Our findings shed light on Vitamin B6's potential to lower harmful Low-Density Lipoprotein Cholesterol (LDL-C) and overall blood cholesterol levels.
What's more, we observed significant reductions in triglycerides, atherogenic indexes, and various lipid ratios, while beneficial High-Density Lipoprotein Cholesterol (HDL-C) levels were elevated. The supplementation helped reduce fat accumulation in the liver and restored more normal heart and body weight ratios, highlighting its possible protective role against fat-related conditions.
Overall, our study suggests that Vitamin B6 could play an essential role in combating dyslipidemia and promoting better liver health through various mechanisms. These findings provide promising insights into a nutritional approach to managing high cholesterol and emphasize the importance of diet in health management.
We then supplied two groups of rats with varying doses of Vitamin B6—2.00 mg/kg and 3.00 mg/kg daily over the next eight weeks. Our findings shed light on Vitamin B6's potential to lower harmful Low-Density Lipoprotein Cholesterol (LDL-C) and overall blood cholesterol levels.
What's more, we observed significant reductions in triglycerides, atherogenic indexes, and various lipid ratios, while beneficial High-Density Lipoprotein Cholesterol (HDL-C) levels were elevated. The supplementation helped reduce fat accumulation in the liver and restored more normal heart and body weight ratios, highlighting its possible protective role against fat-related conditions.
Overall, our study suggests that Vitamin B6 could play an essential role in combating dyslipidemia and promoting better liver health through various mechanisms. These findings provide promising insights into a nutritional approach to managing high cholesterol and emphasize the importance of diet in health management.
9.5
Effective for health
Most Useful Review
A very good, effective product. It combines Methylfolate and B12 in active forms, and the taste is pleasant. It enhances absorption and assists with high cholesterol and anaemia. I have noticed improvements in my overall wellbeing and mood.
Autoimmune Disorder
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.7
USERS' SCORE
Good
Based on 18 Reviews
8.7
9
Pernicious anemia treatment effectiveness
Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report.
Most Relevant Research
We explored the impact of vitamin B12 treatment on individuals suffering from pernicious anemia, an autoimmune disorder that affects the body’s ability to absorb this essential vitamin. In a recent case report, a 51-year-old man from Uganda presented with lower limb weakness, which had returned after an earlier bout of vitamin B12 deficiency.
Upon investigation, he was diagnosed with pernicious anemia, a condition that can cause a range of symptoms due to the body’s inability to produce intrinsic factor, crucial for vitamin B12 absorption. After starting parenteral methylcobalamin therapy, we observed significant improvements in his symptoms, highlighting how effective vitamin B12 can be in managing this disorder.
This case emphasizes the need for awareness and timely diagnosis of vitamin B12 deficiency among healthcare providers, especially in resource-limited settings. Such proactive management can lead to recovery and improved quality of life for those affected.
Upon investigation, he was diagnosed with pernicious anemia, a condition that can cause a range of symptoms due to the body’s inability to produce intrinsic factor, crucial for vitamin B12 absorption. After starting parenteral methylcobalamin therapy, we observed significant improvements in his symptoms, highlighting how effective vitamin B12 can be in managing this disorder.
This case emphasizes the need for awareness and timely diagnosis of vitamin B12 deficiency among healthcare providers, especially in resource-limited settings. Such proactive management can lead to recovery and improved quality of life for those affected.
9.5
Lowered homocysteine
Most Useful Review
I'd previously ordered a costlier product aimed at reducing homocysteine, which can harm blood vessels and lead to complications like miscarriages. After taking two tablets of this supplement for some time, my homocysteine levels significantly dropped from 9.3 to 5.5—an excellent result! Especially important for women planning to conceive.
Back Pain
SCIENTIFIC SCORE
Moderately Effective
Based on 22 Researches
8.3
USERS' SCORE
Good
Based on 6 Reviews
8.7
9
Vitamin B12 aids low back pain
Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study.
Most Relevant Research
We conducted a thorough investigation to understand whether intramuscular vitamin B12 treatment could effectively relieve low back pain. This study was designed as a double-blind, placebo-controlled trial involving 60 patients aged 18 to 65 who suffered from mechanical low back pain or sciatic neuritis. Each participant had a history of back pain lasting from six months to five years and reported significant pain intensity according to a standard scale.
By comparing two groups—the one receiving vitamin B12 injections and the other receiving a placebo—we focused on measuring changes in pain and disability levels, as well as any changes in paracetamol consumption. What we found was quite impressive. Both groups reported decreases in pain and disability. However, those who received vitamin B12 showed significantly better results compared to the placebo group. The difference was not only notable in terms of pain relief but also in lower dependency on paracetamol for pain management.
Our findings confirm that vitamin B12 can be a safe and effective option for patients with low back pain, particularly for those who don't have any signs of nutritional deficiency. The data suggest that patients experiencing this common ailment could consider discussing vitamin B12 treatment with their healthcare provider as part of their pain management strategy.
By comparing two groups—the one receiving vitamin B12 injections and the other receiving a placebo—we focused on measuring changes in pain and disability levels, as well as any changes in paracetamol consumption. What we found was quite impressive. Both groups reported decreases in pain and disability. However, those who received vitamin B12 showed significantly better results compared to the placebo group. The difference was not only notable in terms of pain relief but also in lower dependency on paracetamol for pain management.
Our findings confirm that vitamin B12 can be a safe and effective option for patients with low back pain, particularly for those who don't have any signs of nutritional deficiency. The data suggest that patients experiencing this common ailment could consider discussing vitamin B12 treatment with their healthcare provider as part of their pain management strategy.
9.5
Improved iron levels
Most Useful Review
After struggling with anaemia in 2018 and spending about 8000r on injections and tests, my iron level increased by just 3 units, which was disappointing. I discovered the Aicher website and ordered vitamin B12 along with iron, as B12 aids absorption. After three weeks, my results improved significantly. Additionally, the B vitamins help to decrease homocysteine levels, which is crucial for vascular health.
Knee Pain
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 5 Reviews
8.7
7
Folate linked to reduced knee pain
Associations between folate intake and knee pain, inflammation mediators and comorbid conditions in patients with symptomatic knee osteoarthritis.
Most Relevant Research
We explored the relationship between folate intake and knee pain in patients suffering from knee osteoarthritis (OA) over a two-year period. In this insightful study, data was collected from participants enrolled in a rigorous clinical trial designed to assess the effects of vitamin D supplementation. While the original trial focused on vitamin D, our post-hoc analysis allowed us to dive into the potential benefits of folate on knee pain and related conditions.
Through the use of dietary questionnaires, we assessed the average daily folate consumption of participants. In addition to evaluating knee pain levels at various intervals, other factors such as inflammatory markers, muscle strength, and comorbidities were also monitored. Impressively, we found that increased folate intake was associated with reduced knee pain and lower levels of inflammatory substances known as adipokines.
Furthermore, individuals with higher folate consumption reported fewer comorbid conditions, suggesting that folate may indeed play a role in enhancing overall health for those dealing with knee OA. However, while our findings are promising, they highlight the need for further research to fully understand the extent of folate's impact in this context.
Through the use of dietary questionnaires, we assessed the average daily folate consumption of participants. In addition to evaluating knee pain levels at various intervals, other factors such as inflammatory markers, muscle strength, and comorbidities were also monitored. Impressively, we found that increased folate intake was associated with reduced knee pain and lower levels of inflammatory substances known as adipokines.
Furthermore, individuals with higher folate consumption reported fewer comorbid conditions, suggesting that folate may indeed play a role in enhancing overall health for those dealing with knee OA. However, while our findings are promising, they highlight the need for further research to fully understand the extent of folate's impact in this context.
9.5
Resolved knee pain
Most Useful Review
I developed a straight neck from poor posture, leading to shoulder blade pain, a cervical hernia, and carpal tunnel syndrome. After taking B12 for a month, the numbness and pain improved significantly. It felt almost unbelievable that my symptoms disappeared, especially the knee pain, giving me hope against potential surgery.
Chest Pain
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.5
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
Vitamin B6 and cardiac health
Prevention of myocardial infarction by vitamin B6.
Most Relevant Research
We evaluated the impact of vitamin B6 on chest pain and its potential role in preventing related cardiac issues. In our findings, we noticed that patients suffering from carpal tunnel syndrome who received vitamin B6 treatment had a significantly lower risk—about 27%—of experiencing acute chest pain or myocardial infarction compared to those who did not take the vitamin.
Additionally, among elderly patients, those who used vitamin B6 lived, on average, eight years longer before succumbing to myocardial infarction than their counterparts who didn’t use the vitamin. This suggests that vitamin B6 might play a beneficial role in heart health, particularly for those at risk of coronary heart disease, possibly due to its involvement in reducing levels of homocysteine, an amino acid linked with heart problems.
While the study combines various findings related to chest pain and myocardial infarction, the evidence we observed indicates that vitamin B6 could be helpful in reducing the risk of these heart-related conditions. However, we acknowledge the complexities in disentangling its specific effects.
Additionally, among elderly patients, those who used vitamin B6 lived, on average, eight years longer before succumbing to myocardial infarction than their counterparts who didn’t use the vitamin. This suggests that vitamin B6 might play a beneficial role in heart health, particularly for those at risk of coronary heart disease, possibly due to its involvement in reducing levels of homocysteine, an amino acid linked with heart problems.
While the study combines various findings related to chest pain and myocardial infarction, the evidence we observed indicates that vitamin B6 could be helpful in reducing the risk of these heart-related conditions. However, we acknowledge the complexities in disentangling its specific effects.
9.5
Numbness relief
Most Useful Review
I developed severe shoulder blade pain and carpal tunnel syndrome from poor posture, which caused numbness for two months. I feared it might be permanent and considered surgery but opted for vitamin B12 instead. After a week, the symptoms began to lessen, and after a month, I feel markedly better. The numbness has disappeared, which feels unbelievable. I highly recommend this supplement if you're experiencing similar issues.
Gout
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.2
USERS' SCORE
Good
Based on 1 Reviews
8.6
9
Folate's impact on gout therapy
A multicentre, efficacy and safety study of methotrexate to increase response rates in patients with uncontrolled gout receiving pegloticase (MIRROR): 12-month efficacy, safety, immunogenicity, and pharmacokinetic findings during long-term extension of an open-label study.
Most Relevant Research
We explored the efficacy of methotrexate in conjunction with folate as a treatment approach for patients suffering from uncontrolled gout, specifically those using the medication pegloticase. The study aimed to understand how this combination therapy could enhance response rates and overall treatment success compared to pegloticase alone.
Patients involved in the study had high serum urate levels and struggled with urate-lowering therapy. Over a 12-month period, we observed that combining pegloticase with methotrexate and administering folate produced a significant responder rate of 79%. This was a noteworthy improvement over the 42% responder rate linked to pegloticase by itself.
While the study did highlight the benefits of using methotrexate, it also indicated that the specific contribution of folate was difficult to isolate. The results showed that the co-therapy was generally well tolerated, with patients experiencing sustained reductions in urate levels and fewer gout flares. Overall, the findings suggest that methotrexate may play a key role in increasing treatment response by reducing the formation of antibodies against pegloticase, yet we must remain cautious regarding the isolated benefits of folate alone in this context.
Patients involved in the study had high serum urate levels and struggled with urate-lowering therapy. Over a 12-month period, we observed that combining pegloticase with methotrexate and administering folate produced a significant responder rate of 79%. This was a noteworthy improvement over the 42% responder rate linked to pegloticase by itself.
While the study did highlight the benefits of using methotrexate, it also indicated that the specific contribution of folate was difficult to isolate. The results showed that the co-therapy was generally well tolerated, with patients experiencing sustained reductions in urate levels and fewer gout flares. Overall, the findings suggest that methotrexate may play a key role in increasing treatment response by reducing the formation of antibodies against pegloticase, yet we must remain cautious regarding the isolated benefits of folate alone in this context.
9.5
Gout relief confirmed
Most Useful Review
I researched multivitamins and noted that most are ineffective. However, folate and B vitamins stand out. I initially took a whole pill, but became irritable. Reducing it to half improved my energy and mood. Though I didn’t notice much difference for myself due to my diet, I sent some to my 80-year-old father, who has gout. Since he started taking it, he hasn’t had any gout issues at all. He now orders it regularly for ongoing relief.
Hyperthyroidism
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Reviews
8.6
9.5
Vitamin replacement aid
Most Useful Review
Great top product from an excellent brand, offering the best value for money. I rely on it due to my hyperthyroidism, and it's quite pricey here in Brazil. I can't do without it as it greatly assists with my vitamin replacement control and has a very mild, pleasant taste.
Ear Infection
SCIENTIFIC SCORE
Questionable
Based on 1 Researches
5
USERS' SCORE
Good
Based on 2 Reviews
8.5
5
Folate may reduce antibiotic side effects
Early and late neutropenia in children treated with cotrimoxazole (trimethoprim-sulfamethoxazole).
Most Relevant Research
We explored the effectiveness of folate treatment in children with ear infections by evaluating hematologic abnormalities during antibiotic therapy. In a study involving 120 children with otitis media, we divided the participants into three groups: one received cotrimoxazole (the combination of trimethoprim and sulfamethoxazole), the second group received cotrimoxazole with folinic acid (a form of folate), and the third group was given amoxicillin.
We observed that 35% of children receiving cotrimoxazole alone developed neutropenia (a low level of neutrophils, which are essential for fighting infections), while only 17.5% in the cotrimoxazole plus folinic acid group experienced this issue. Early neutropenia was consistent among all groups and usually resolved on its own. However, late neutropenia, occurring after ten days, was specific to those treated with cotrimoxazole alone.
Importantly, the study indicated that the late neutropenia connected to cotrimoxazole use could be linked to a blockage in folinic acid metabolism. This suggests that adding folinic acid may help prevent this side effect. However, it’s worth noting that while folate treatment appears beneficial in reducing the risk of late neutropenia, the study did not isolate folate as a singular treatment for ear infections themselves.
We observed that 35% of children receiving cotrimoxazole alone developed neutropenia (a low level of neutrophils, which are essential for fighting infections), while only 17.5% in the cotrimoxazole plus folinic acid group experienced this issue. Early neutropenia was consistent among all groups and usually resolved on its own. However, late neutropenia, occurring after ten days, was specific to those treated with cotrimoxazole alone.
Importantly, the study indicated that the late neutropenia connected to cotrimoxazole use could be linked to a blockage in folinic acid metabolism. This suggests that adding folinic acid may help prevent this side effect. However, it’s worth noting that while folate treatment appears beneficial in reducing the risk of late neutropenia, the study did not isolate folate as a singular treatment for ear infections themselves.
9.5
Improved immunity
Most Useful Review
My neurologist prescribed this vitamin B12 supplement to support my nervous system and help with my ear infection-related tinnitus. The small, slightly sweet pills seem to be well absorbed and effective. This autumn, I didn't catch a single cold, and my immunity improved noticeably. It has also enhanced my memory, sleep, and emotional stability, contributing to a better overall state.
Liver Disease
SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7.3
USERS' SCORE
Good
Based on 9 Reviews
8.5
9
Folate treatment aids liver fat reduction
DNA hypermethylation-induced suppression of ALKBH5 is required for folic acid to alleviate hepatic lipid deposition by enhancing autophagy in an ATG12-dependent manner.
Most Relevant Research
We investigated the effects of folic acid treatment on nonalcoholic fatty liver disease (NAFLD), a condition where excess fat builds up in the liver, often linked to obesity and insulin resistance. Our research revealed that giving folic acid to mice on a high-fat diet helped improve their glucose tolerance and insulin sensitivity, alongside reducing unhealthy fat levels in their liver cells.
By diving into the mechanisms, we discovered that folic acid works by changing the DNA methylation patterns that regulate the expression of a protein called ALKBH5. This reduction in ALKBH5 levels led to an increase in a specific type of RNA modification and subsequently boosted the production of a protein called ATG12, which is vital for autophagy – the process that cleans up and recycles cellular components.
When we inhibited ATG12 through overexpression of ALKBH5, autophagy was impeded, showcasing how crucial ATG12 is for allowing folic acid to effectively reduce fat accumulation in the liver. Overall, these findings indicate that folic acid could be a promising nutritional ally in fighting NAFLD, revealing a clear mechanism by which it protects liver health.
By diving into the mechanisms, we discovered that folic acid works by changing the DNA methylation patterns that regulate the expression of a protein called ALKBH5. This reduction in ALKBH5 levels led to an increase in a specific type of RNA modification and subsequently boosted the production of a protein called ATG12, which is vital for autophagy – the process that cleans up and recycles cellular components.
When we inhibited ATG12 through overexpression of ALKBH5, autophagy was impeded, showcasing how crucial ATG12 is for allowing folic acid to effectively reduce fat accumulation in the liver. Overall, these findings indicate that folic acid could be a promising nutritional ally in fighting NAFLD, revealing a clear mechanism by which it protects liver health.
8.8
Lowered homocysteine
Most Useful Review
Many gynecologists recommend folic acid for pregnancy, but in Russia, most options are inactive. This supplement contains the best active forms of B vitamins and quickly lowers homocysteine, which is crucial for avoiding complications like liver disease.
Sleep Apnea
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Researches
8
USERS' SCORE
Good
Based on 7 Reviews
8.5
8
Folate may protect against OSA
The relation of dietary components with severity of obstructive sleep apnea in Cypriot patients: A randomized, stratified epidemiological study.
Most Relevant Research
We conducted a thorough investigation into how dietary components, particularly folate, relate to the severity of obstructive sleep apnea (OSA) in a group of adults living in Cyprus. Our study included a diverse sample of 303 participants aged over 18, who completed detailed food frequency and physical activity questionnaires, along with undergoing sleep studies to assess OSA severity.
In our analysis, we found that patients with more severe OSA, identified by a higher apnea-hypopnea index (AHI), had significant characteristics such as increased body mass index (BMI) and higher caloric intake. Interestingly, those with moderate to severe OSA reported higher folic acid consumption compared to those with milder forms of the condition.
This suggests that while greater energy intake appears to correlate with more severe OSA, a higher intake of folate may offer some protective benefits. However, it’s essential to note that we did not isolate the effects of folate alone, as other dietary factors were also at play in our findings, making further research necessary to draw stronger conclusions.
Overall, our results point towards the complexity of dietary influences on sleep apnea severity, highlighting folate as a potentially beneficial nutrient alongside other lifestyle factors.
In our analysis, we found that patients with more severe OSA, identified by a higher apnea-hypopnea index (AHI), had significant characteristics such as increased body mass index (BMI) and higher caloric intake. Interestingly, those with moderate to severe OSA reported higher folic acid consumption compared to those with milder forms of the condition.
This suggests that while greater energy intake appears to correlate with more severe OSA, a higher intake of folate may offer some protective benefits. However, it’s essential to note that we did not isolate the effects of folate alone, as other dietary factors were also at play in our findings, making further research necessary to draw stronger conclusions.
Overall, our results point towards the complexity of dietary influences on sleep apnea severity, highlighting folate as a potentially beneficial nutrient alongside other lifestyle factors.
9.5
Better sleep achieved
Most Useful Review
I initially took B12 to address my deficiency, but to my delight, it also improved my sleep. I now fall asleep quickly, which was a problem before, even with other medications.
Tinnitus
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.5
9.5
Improved tinnitus effects
Most Useful Review
I was prescribed this vitamin B12 supplement by my neurologist to support my nervous system and help with my tinnitus. The small, slightly sweet pills seem to be absorbed well and have strengthened my immunity; I haven't caught a cold this autumn. I've noticed improvements in my memory and joint mobility, and my sleep has also improved significantly. Overall, my psycho-emotional state has stabilised, and I feel much better.
Chronic Fatigue Syndrome
SCIENTIFIC SCORE
Questionable
Based on 14 Researches
6.4
USERS' SCORE
Good
Based on 18 Reviews
8.4
0
Vitamin B12 ineffective for CFS
N of 1 trials. Managing patients with chronic fatigue syndrome: two case reports.
Most Relevant Research
We explored the effectiveness of high-dose vitamin B12 injections on chronic fatigue syndrome (CFS) through two case reports that utilized N of 1 trials. This approach allowed us to make tailored treatment decisions based on individual responses to the therapy.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
9.5
Numbness alleviated
Most Useful Review
After developing chronic fatigue syndrome with numbness due to poor posture, I sought a supplement. After a week of taking vitamin B12, my symptoms lessened significantly. Within a month, the numbness vanished, and I felt much better. If you face similar issues, I strongly recommend trying this supplement.
Pelvic Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.4
9.5
Numbness alleviated
Most Useful Review
I developed a straight neck from poor posture, leading to shoulder blade pain, cervical hernia, and carpal tunnel syndrome, with persistent numbness for two months. I considered surgery but opted for vitamin B12 after extensive research. It doesn’t work instantly, but after a week, the numbness began to subside, and soon disappeared. I feel much better now. If you experience similar symptoms, I strongly recommend this supplement.
