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Supplement Facts
Serving Size:  1 Vegetarian Tablet
Amount Per Serving
%DV
Vitamin C (as ascorbic acid)
1000 mg
1111%
Bio-Quercetin® Proprietary Blend[providing 35% quercetin (5 mg) [from Japanese sophora concentrate (flower bud)],30% galactomannans (4 mg) [from fenugreek (seed)]
15 mg
**

The product is found useful for the following medical conditions

Cold Sores

SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.3
USERS' SCORE
Good
Based on 6 Reviews
8.9
9
Vitamin C alleviates cold sores
Topical treatment of recurrent mucocutaneous herpes with ascorbic acid-containing solution.
Most Relevant Research
We investigated how an ascorbic acid-based solution could help treat recurrent cold sores, also known as mucocutaneous herpes. This study was carefully designed as a randomized, double-blind, placebo-controlled trial, which helps ensure the results are reliable and trustworthy.

Participants used a strong solution of Ascoxal, rich in vitamin C, applied to their cold sores multiple times on the first day of the outbreak. We monitored various symptoms daily, including the severity of scabs, redness, and blisters, comparing the experiences of those using the vitamin C solution to a placebo group.

Our findings were promising: the active treatment resulted in fewer days with scabbing and less severe symptoms overall. Moreover, those using the vitamin C solution showed reduced persistence of scabs compared to the placebo group, along with a lower frequency of detected herpes virus after treatment.

In conclusion, this brief course of vitamin C treatment appears to have significant clinical benefits against cold sores, opening the door for future research on more extensive and frequent treatment regimes.
9.5
Reduces cold sores
Most Useful Review
A fantastic option for vitamin C. I generally purchase various types, particularly those with bioflavonoids. Not all ascorbic acid is effective, but this one with bioquercetin delivers noticeable results. If I'm coming down with a cold, taking a high dose can often prevent illness. My cold sores diminish within a day. The tablets are small and can be easily split.

Common Cold

SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.4
USERS' SCORE
Good
Based on 70 Reviews
8.9
8
Vitamin C reduces cold severity
Vitamin C reduces the severity of common colds: a meta-analysis.
Most Relevant Research
We explored how vitamin C affects the severity of common colds through a comprehensive review of available studies. By including only randomized, placebo-controlled trials where participants received at least 1 gram of vitamin C daily, we aimed to investigate both the overall duration of colds and the intensity of symptoms experienced.

Our analysis found that vitamin C significantly reduced the severity of cold symptoms by about 15%. Interestingly, it appears that the benefits are more pronounced for those experiencing severe symptoms compared to mild ones. In specific comparisons, vitamin C didn’t substantially affect the duration of mild symptoms but had a notable impact on how long severe symptoms lasted.

This insight is crucial, as the common cold often leads to absenteeism at work and school, with more severe symptoms playing a key role in this setback. By highlighting vitamin C's greater effectiveness against intense cold symptoms, we suggest that future research should continue to look into how this vitamin can be utilized in managing cold severity.
9.5
Effective prevention
Most Useful Review
A great option for vitamin C. I prefer those containing bioflavonoids. In this case, with bioquercetin, its effect is noticeably helpful. If I feel a cold coming on, taking this vitamin C can prevent the common cold if taken in a loading dose. My herpes heals within a day. The small tablets are easy to split in half.

Allergies

SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 35 Reviews
8.8
8
Pleuran and Vitamin C aid asthma
Beneficial effects of pleuran on asthma control and respiratory tract-infection frequency in children with perennial asthma.
Most Relevant Research
We conducted a thorough evaluation of how vitamin C, when combined with pleuran, impacts asthma control and respiratory issues in children suffering from perennial asthma. The study was meticulously designed as a double-blind, placebo-controlled trial involving 230 children aged 7 to 17 years. This means that neither the participants nor the researchers knew who was receiving the active treatment or the placebo, ensuring the findings were reliable.

The results were promising, especially for children under 12 years. They showed significant improvements in asthma control compared to those receiving only the placebo treatment. Meanwhile, older children (12 years and above) experienced fewer respiratory infections with the combination treatment. Overall, by the end of the 48 weeks, a majority of children on the pleuran and vitamin C treatment reported better asthma control compared to those on the placebo.

While the combination of pleuran and vitamin C was indeed beneficial for managing asthma, we must note that the study did not specifically isolate the effect of vitamin C alone on allergies or asthma. Thus, it is hard to draw definitive conclusions about vitamin C's effectiveness independently from pleuran. However, the approach suggested that using these supplements together could offer a helpful boost in managing asthma symptoms.
9.5
Immunity support
Most Useful Review
A great product of very good quality. The composition is excellent and easily digestible, without causing discomfort. I can finally take vitamin C without my stomach reacting. My family takes it each morning for immunity. Highly recommend, especially in autumn!

Autoimmune Disorder

SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8
USERS' SCORE
Good
Based on 11 Reviews
8.7
9
Vitamin C impacts autoimmune response
Ascorbic acid alleviates rheumatoid arthritis by inhibiting the production of autoantibodies.
Most Relevant Research
We investigated how vitamin C, also known as ascorbic acid, might impact autoimmune disorders like rheumatoid arthritis. Through a study involving a mouse model of collagen-induced arthritis, we administered vitamin C or a placebo solution and observed the effects on the immune response and disease progression.

Notably, the research showed that mice given vitamin C experienced a significant delay in the onset of arthritis and a reduction in disease severity. This suggests that vitamin C can play a critical role in managing autoimmune conditions by minimizing the production of autoantibodies, which are harmful antibodies that mistakenly attack the body's tissues.

Our findings revealed that vitamin C reduced the number of plasma cells and decreased antibody production in response to immunization. This indicates that vitamin C influences the immune system's response at a cellular level, helping to prevent the emergence of autoreactive plasma cells. We also discovered that the mechanism behind this effect involved inhibiting the Stat3 signaling pathway, leading to less activation of autoreactive immune components.

Ultimately, these results highlight the potential of vitamin C not just as a nutrient, but as a strategic tool in managing autoimmune disorders. By simply supplementing with vitamin C, there may be a way to intervene positively in the progression of diseases like rheumatoid arthritis.
9.5
Trustworthy immune support
Most Useful Review
Vitamin C + Quercetin supports immunity! I'm confident in this brand, having used many of their products. The 250-capsule packaging lasts long. This combination, a strong antioxidant, is invaluable and family-friendly. They are easy to swallow, and I’ve noticed significant immunity support during illness. I will keep ordering!

Cardiovascular Disease

SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8
USERS' SCORE
Good
Based on 17 Reviews
8.7
7
Vitamin C enhances NK cell proliferation
Proliferation capability of natural killer cells upon cytokines stimulation correlated negatively with serum lactate dehydrogenase level in coronary artery disease patients.
Most Relevant Research
We explored the effects of vitamin C on natural killer (NK) cell activity in patients with coronary artery disease (CAD). Our research involved isolating NK cells from 29 CAD patients and treating them with various stimulatory factors, including ascorbic acid—better known as vitamin C.

What we found was quite interesting: when NK cells were treated with ascorbic acid, there was a significant increase in their ability to proliferate. This meant that the NK cells were more active and potentially more effective in responding to threats in the body, which is vital for those dealing with heart conditions.

Furthermore, we measured serum lactate dehydrogenase (LDH) levels, discovering a negative correlation between LDH and NK cell activity. Higher LDH levels seemed to indicate lower proliferation capability in NK cells influenced by interleukins.

Overall, our study suggests that vitamin C could play a positive role in enhancing immune function in CAD patients by promoting NK cell proliferation. However, it's important to note that while vitamin C shows promise, further research is needed to fully understand its impact on cardiovascular health and immune regulation.
9.5
Essential for health
Most Useful Review
This vitamin C supplement strengthens the immune system and supports cardiovascular health. It also promotes tissue repair and counteracts flu-like symptoms from deficiency. The dosage of 1000 mg is perfect for maintenance, and it's easy on the stomach, making it essential for my cardiovascular disease management.

Gout

SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 3 Reviews
8.6
8
Dietary Vitamin C and Gout
Association between dietary vitamin C intake and gout among American adults.
Most Relevant Research
We investigated the potential relationship between dietary vitamin C intake and gout among American adults using data from the National Health and Nutrition Examination Survey conducted between 2013 and 2018. This study included participants over the age of 20 and looked at various factors, including the incidence of gout and levels of vitamin C intake.

Our findings revealed that 5% of the 12,589 participants reported experiencing gout. Interestingly, those consuming higher amounts of dietary vitamin C showed a lower likelihood of developing gout. Specifically, individuals in the highest intake group had an odds ratio of 0.77 for having gout, suggesting an inverse relationship between vitamin C intake and gout occurrence.

We noted that this relationship exhibited an L-shaped pattern, indicating that increased vitamin C consumption may be linked to reduced gout risk, particularly among different sex groups. However, when we examined vitamin C supplements, no significant association with gout was observed. Overall, our research highlights the potential benefits of dietary vitamin C in preventing gout, while underscoring the need for more focused studies in this area.
8.8
Improved immunity
Most Useful Review
The vitamin C that I have repurchased numerous times has a stronger antioxidant effect than pure VC, and I find it very effective for gout. Regular use seems to enhance my immunity.

High Cholesterol

SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8
USERS' SCORE
Good
Based on 3 Reviews
8.6
9
Vitamin C reduces cholesterol levels
Effect of Using Vitamin C Supplementation on Performance, Blood Parameters, Carcass Characteristics and Meat Quality of Broiler Chickens Under Heat Stress Condition: A Meta-Analysis.
Most Relevant Research
We explored how vitamin C supplementation affects cholesterol levels in broiler chickens, particularly under heat stress conditions. Through a thorough meta-analysis of 35 studies conducted between 1985 and 2023, we assessed various performance metrics, including blood parameters, carcass characteristics, and overall meat quality.

Our findings revealed that vitamin C significantly reduced cholesterol levels in the broiler chickens subjected to heat stress. Specifically, the study reported a notable decrease in cholesterol concentrations, with a standard mean difference of -0.976, indicating a strong beneficial effect of vitamin C in managing high cholesterol.

Additionally, we noticed improvements in body weight and average daily gain among chickens receiving vitamin C when compared to those that did not. While vitamin C did not significantly impact feed intake or breast meat quality, it emerged as a valuable antioxidant that can help lower blood triglycerides and reduce cholesterol, thus promoting better overall health and growth in broilers during stressful conditions.

Ultimately, this meta-analysis supports the use of vitamin C at a recommended dosage of 250 mg/kg as an effective growth promoter and antioxidant in broiler diets under heat stress, directly influencing cholesterol management.
9.5
Supports cholesterol normalisation
Most Useful Review
This vitamin C with quercetin is excellent! Quercetin aids in various conditions, including high cholesterol, insulin regulation, and inflammation. The effects are noticeable from the outset. I use it for allergies, viral infections, and managing diabetes, finding it particularly effective when combined with vitamin C and rutin.

Pelvic Pain

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
Pain relief noted
Most Useful Review
After two weeks on this medication, I felt an increase in energy, my movement improved, and the pelvic pain I experienced vanished. I used to rely on painkillers, but now I've decided to stop them. I'll continue to take it in courses, though it's unfortunate it isn’t always available.

Pneumonia

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
Significant improvement
Most Useful Review
I find this combination of Vitamin C and Quercetin excellent value, particularly during these Covid times. After struggling for months with post-nasal drip following pneumonia, I started taking this supplement regularly. Within just two days, I saw a 90 per cent improvement in my symptoms. I never want to be without it again.

Urinary Tract Infection

SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.1
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Vitamin C shows promise for UTIs
Network analysis, and human and animal studies disclose the anticystitis glandularis effects of vitamin C.
Most Relevant Research
We explored how vitamin C (VC) might help in treating cystitis glandularis (CG), a condition often linked with urinary tract infections (UTIs). Utilizing network pharmacology, we identified potential therapeutic targets of VC and the biological pathways it may influence to alleviate CG symptoms.

Our study involved both bioinformatic analyses and real-world observations, including human and animal studies. Through these methodologies, we pinpointed key biomarkers associated with CG, such as TNF-α, IL6, and c-Jun, which were notably elevated in patient samples.

Encouragingly, when VC was administered to mice with CG, we observed a significant decrease in these inflammatory markers in both blood and bladder samples. This suggests that VC could play a beneficial role in reducing symptoms associated with UTIs by targeting these key molecular pathways.
9.5
Improved symptoms
Most Useful Review
This product helped with my urinary tract infection, as prescribed by my gynaecologist. After a week, I noticed significant improvement, and it also reduced my seasonal allergy discomfort. The tablets have a pleasant citrus flavour and are slightly acidic.

Cold

SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 1 Review
8.6
7
Effectiveness of Vitamin C on Colds
Vitamin C for the common cold and pneumonia.
Most Relevant Research
We explored the effects of vitamin C on the common cold and pneumonia by examining a range of studies. Interestingly, research on animals suggests that vitamin C may have protective effects against infections. However, when it comes to preventing colds in the general population, taking more than 1 gram of vitamin C per day didn’t show significant benefits.

But there's a twist! Participants engaged in heavy physical activities saw their cold incidence reduced by half with vitamin C supplementation. Additionally, regular intake of 1 gram or more daily was linked to a 15% decrease in cold severity. While some therapeutic trials showed inconsistent results when vitamin C was taken after cold symptoms appeared, two studies did indicate that larger doses (6-8 grams per day) could effectively shorten the duration of colds compared to lower doses.

Our investigation also looked into pneumonia, but the studies were conducted in unique settings, such as a boarding school and military recruits. This makes it hard to generalize the findings to the wider population. Yet, some trials suggested benefits for pneumonia patients. Finally, the role of vitamin C in treating COVID-19 and sepsis remains unclear, with mixed results.

Given that vitamin C seems to alleviate symptoms and shorten the duration of colds, while being safe and affordable, it might be worth considering a dose of 6-8 grams per day to see if it helps at an individual level.
9.5
Quick cold relief
Most Useful Review
Fast Results! I had a cold for 2 or 3 days, took one pill, and the next morning it was 90% better! I’m not certain if it was due to the quercetin or just the Vitamin C, but it was an extraordinary improvement overnight!

Cough

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
10
Strong immunity
Most Useful Review
Highly effective! This product is like putting on armour against coughs, sneezes, and wheezing. My resistance seems to rise exponentially when using it.

Ear Infection

SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.7
USERS' SCORE
Good
Based on 1 Review
8.5
9
Vitamin C aids ear infection recovery
Malignant external otitis and polymorphonuclear leukocyte migration impairment. Improvement with ascorbic acid.
Most Relevant Research
We observed that malignant external otitis (MEO), a severe infection of the outer ear often found in elderly patients with uncontrolled diabetes, can significantly impair the body's defense mechanisms. In a notable case, a 58-year-old man struggling with MEO had faced months of ineffective treatments.

To delve deeper, we tested the function of his immune cells, specifically his polymorphonuclear neutrophil leukocytes (PMNs), which play a crucial role in fighting infections. Our findings revealed that his PMNs had difficulty migrating to the site of infection, a critical step for addressing such health issues.

We discovered that ascorbic acid, commonly known as vitamin C, could improve this migration defect in laboratory tests. In practical terms, after just one month of vitamin C treatment, the patient's chemotaxis results normalized, and remarkably, his ear lesions began to heal.

Even though the exact reasons for the PMN dysfunction remain unclear, possibly due to factors like age and diabetes, this case highlights the importance of assessing PMN function in MEO patients and suggests that immunomodulators like vitamin C might offer a valuable treatment pathway.
8
Supports immune system
Most Useful Review
Great combination tablets. They keep my immune system functioning well, and the added quercetin aids in thinning mucus and alleviating head and ear congestion issues.

Heart Attack

SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 1 Review
8.5
7
Antioxidants tested for heart attacks
Safety and Pharmacokinetics of a Combined Antioxidant Therapy against Myocardial Reperfusion Injury: A Phase 1 Randomized Clinical Trial in Healthy Humans.
Most Relevant Research
In a recent clinical trial, we examined how a combination of antioxidants, including vitamin C, affects heart attack recovery. This study involved healthy participants who received either a blend of antioxidants or a placebo through an intravenous infusion. We measured the levels of vitamin C and other components in the blood, looking for signs of oxidative stress and monitoring any adverse effects.

Our findings showed that the antioxidant combination significantly increased vitamin concentrations compared to the placebo group. Moreover, we observed that this therapy seemed safe, with only mild, non-serious side effects reported in a small number of participants.

While antioxidants like vitamin C have been linked to health benefits, this study focused primarily on their safety and levels in the blood during a heart-related procedure. Although promising, we cannot definitively say that this approach improves outcomes for heart attack patients just yet. More research will be needed to explore its effectiveness further.
8.8
Supports heart recovery
Most Useful Review
During the 2020 pandemic, I chose this Life Extension vitamin C formula as it provides a solid dosage of 1000 mg in ascorbic acid, to be taken with meals. The addition of bio-quercetin from Sophora of Japan aids in recovery and has proven beneficial for treating capillary ailments. After suffering from Covid and experiencing weakness and heart irregularities, this vitamin C helped me. Quercetin enhances the absorption of vitamin C and zinc and reduces chronic vascular disease risks, supporting my heart health.

Heart Disease

SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.8
USERS' SCORE
Good
Based on 8 Reviews
8.5
7
Vitamin C's uncertain heart benefits
Role of Vitamins in Cardiovascular Health: Know Your Facts - Part 1.
Most Relevant Research
We aimed to understand the role of vitamin C in heart disease and its potential cardioprotective effects. Vitamin C is renowned for its antioxidant properties, which means it fights off harmful substances in our body, potentially reducing the risk of heart issues.

Our analysis revealed that vitamin C could play a meaningful role in supporting cardiovascular health. While the evidence is promising, it is important to be cautious, as clinical studies have shown mixed results regarding its effectiveness.

So, while vitamin C might contribute positively to heart health, more solid evidence is required to fully confirm these effects. Overall, we learned that while there are positive indicators, we should be careful about over-relying on vitamin C as a sole preventive measure for heart disease.
9.5
Highly effective
Most Useful Review
I've used this vitamin C for a long time and am extremely satisfied. At the first sign of illness, I increase the dosage, and it works exceptionally well alongside curcumin.

Chronic Cough

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.4
8.8
Effective treatment
Most Useful Review
My mother suffered from a chronic cough due to chronic bronchitis. After two weeks of various medications and inhalations without improvement, we added quercetin with zinc, selenium, omega 3, and vitamins D3/K2 to her regimen. The results have been encouraging, especially after including milk thistle for liver support.

Blood Clot

SCIENTIFIC SCORE
Questionable
Based on 6 Researches
6.7
USERS' SCORE
Good
Based on 7 Reviews
8.3
9
Vitamin C enhances blood clotting
Ascorbic acid improves thrombotic function of platelets during living donor liver transplantation by modulating the function of the E3 ubiquitin ligases c-Cbl and Cbl-b.
Most Relevant Research
We sought to understand how ascorbic acid, commonly known as vitamin C, impacts blood clotting during living donor liver transplantation (LDLT). In our study, we analyzed blood samples from 21 recipients before and after their surgeries.

We employed a well-structured approach, using rotational thromboelastography (TEG) and western blot analysis to scrutinize fibrinolysis and the functionality of specific proteins involved in clotting. Blood samples were tested in three distinct groups, one receiving vitamin C, to see its effects on clot rigidity and fibrinolysis.

Our findings revealed that ascorbic acid notably reduced fibrinolysis, which refers to the breakdown of blood clots, and improved the rigidity of the clots formed. Additionally, we observed that levels of a protein called Cbl-b were higher in those receiving vitamin C, while another protein, c-Cbl, showed reduced phosphorylation. These functional changes might explain how vitamin C supports better clotting during surgeries.

This study indicates that vitamin C could be a beneficial treatment to consider during LDLT to manage hyperfibrinolysis, thus promoting better outcomes for patients undergoing these complex procedures.
9.5
Enhanced blood flow
Most Useful Review
An excellent supplement for immunity in COVID-19, quercetin can effectively prevent blood clots, reduces inflammation, and stops viruses from entering cells. I take it daily with iron, and if I feel weak or have a headache, I increase my dosage to two tablets, after which I feel much better.

Liver Disease

SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.9
USERS' SCORE
Good
Based on 1 Review
8
9
Vitamin C reduces liver injury
The Effect of Ascorbic Acid on Hepatic Ischaemia-Reperfusion Injury in Wistar Rats: An Experimental Study.
Most Relevant Research
We evaluated how vitamin C, also known as ascorbic acid, can help protect the liver during procedures that temporarily cut off blood flow—a process known as ischaemia followed by reperfusion. In this study, we used thirty-six male Wistar rats, split into control groups and experimental ones. Each group received the same total dose of vitamin C, administered at different times: either before the ischaemia, before the reperfusion, or both.

Our findings showed that the animals given vitamin C before both the ischaemia and reperfusion had improved outcomes. They had lower levels of liver enzymes, indicating less liver damage, and showed reduced inflammation. Additionally, their portal blood flow was better when compared to the other groups. Overall, our results suggest that administering vitamin C at specific times can significantly reduce liver injury associated with ischaemia-reperfusion.

This study highlights the potential of vitamin C as a protective agent in situations where liver damage is a concern during surgeries or treatments involving blood flow disruption.
3.5
Reduced liver strain
Most Useful Review
I honestly don’t know what to say. I took this to boost immunity for me and my family, but I've realised it is crucial to avoid excess, particularly due to preservatives that may impact the liver, especially for those like me with liver disease. I decided to reduce supplements and opt for alternatives like tripe and baobab, which I adore. I didn’t use this product daily and instead provided it to my children for their vitamin C needs. If my review has helped you, please give me a thumbs up.
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