NOW Supplements Vitamin A 25000 IU

We investigated how retinoic acid (RA), a derivative of vitamin A, could influence cancer treatment, particularly in glioma, a type of brain tumor. Previous attempts to use RA as a therapeutic option were inconclusive, so we aimed to explore its effects alongside extracellular ATP (eATP) to harness their combined potential.

Our experiments examined two human glioma cell lines, M059K and M059J, to see how they responded to RA-based differentiation. Notably, this process led to changes in the expression of a receptor called P2X7 and reduced the activity of enzymes that break down nucleotides. These modifications contributed to a significant decrease in cell proliferation and migration abilities, as well as an increased sensitivity to the effects of eATP.

Specifically, we found that in the presence of eATP, cell viability decreased by up to 40% in RA-treated M059K cells and 20% in M059J cells. Migration capabilities of the cells were reduced by as much as 60% when exposed to a specific concentration of ATP, showing that the P2X7 receptor plays a major role in mediating these effects.

Our observations suggest that combining retinoic acid with eATP can have anti-cancer benefits by influencing purinergic signaling pathways in glioma cells. This points to the need for further exploration of P2X7 receptor variants as potential therapeutic targets for treating glioma.

9.5

Improved gastritis

Most Useful Review

The required amount of Vitamin A varies significantly depending on individual circumstances. Those with dry eye, asthma, gastrointestinal issues, or a family history of cancer may require more. I gradually increased my intake to 100,000 units for a year, which cleared my persistent red sore gastritis, eliminating the need for medication.

Ulcer

The required dosage of vitamin A varies significantly between individuals, particularly for those with dry eyes, asthma, gastrointestinal issues, or a history of cancer. Due to my low protein intake, I've gradually increased my dosage to 100,000 units over a year. Remarkably, my persistent gastritis, unresolved for over ten years, has cleared, eliminating the need for medication.

Acne

SCIENTIFIC SCORE

Moderately Effective

Based on 16 Researches

Vitamin A's effectiveness in acne

The role of vitamins and nutrients in rosacea.

Most Relevant Research

We explored how vitamin A can influence acne treatment, focusing on the effectiveness of its derivatives. According to the findings, oral isotretinoin, a form of vitamin A, showed remarkable efficacy. Patients experienced a significant reduction in lesions—up to 90%—with complete remission in one-quarter of those involved in the study.

Moreover, more than half of the participants reported substantial improvement after treatment. This strong performance suggests that vitamin A plays a key role in managing acne symptoms effectively.

Overall, the evidence we examined indicates that incorporating vitamin A, particularly through isotretinoin, can lead to significant improvements for individuals struggling with acne.

9.5

Improved skin health

Most Useful Review

As a longtime acne sufferer, I've tried everything from Accutane to various skincare products without success. In just a week of using this supplement, I saw tremendous improvement; my skin appears clearer, my pores are smaller, and I'm even comfortable without makeup for the first time. The reduction in acne is phenomenal, with noticeable changes in texture and tone. For better absorption, I take it with a healthy fat like coconut oil, which I highly recommend.

Chronic Cough

Improved chronic cough

Most Useful Review

Respite Vitamin A is essential for mucous membranes, so I purchased it for my husband with severe asthma. I struggled to sleep due to suffocation, but after taking 100,000 IU daily, I noticed a significant improvement within a month. His daytime cough has also decreased dramatically. However, high doses of vitamin A can result in vitamin K deficiency, so I recommend consuming natto alongside it.

Hypothyroidism

SCIENTIFIC SCORE

Possibly Effective

Based on 10 Researches

Vitamin A benefits thyroid function

The effect of vitamin A supplementation on thyroid function in premenopausal women.

Most Relevant Research

We conducted a thorough investigation into how vitamin A supplementation might impact thyroid function, particularly focusing on women who are premenopausal and have varying body weights. Our study was a robust, four-month randomized controlled trial involving 84 healthy women aged 17 to 50. Among them, 56 women were classified as obese, while 28 fell into the nonobese category.

Throughout the study, we administered 25,000 IU of vitamin A or a placebo to the obese participants, while nonobese participants received vitamin A as well. Before and after the supplementation period, we measured key thyroid markers, including thyroid-stimulating hormone (TSH), total thyroxine (T4), total triiodothyronine (T3), and proteins associated with vitamin A transport.

Our findings revealed that vitamin A supplementation significantly reduced TSH concentrations in both the obese and nonobese groups, suggesting it may help mitigate the risk of subclinical hypothyroidism. Interestingly, we also noticed an increase in serum T3 levels among those treated with vitamin A. However, T4 levels decreased across all groups, including those not receiving vitamin A.

Overall, it appears that vitamin A may serve as a beneficial intervention for thyroid function in women, particularly those at risk for hypothyroidism. This research highlights an accessible avenue to better support thyroid health through dietary supplementation.

9.5

Improved vitamin levels

Most Useful Review

Working drug! My doctor said, "Vitamin A is essential for your mucous membranes." My vitamin A levels have significantly increased, which is crucial for someone with hypothyroidism. The capsules are small and easy to take; I also ensure to take them with fats for better absorption.

Allergies

SCIENTIFIC SCORE

Likely Very Effective

Based on 2 Researches

Vitamin A and allergy management

Retinoic Acid (RA): A Critical Immunoregulatory Molecule in Asthma and Allergies.

Most Relevant Research

Our exploration into the effects of vitamin A, particularly its active form known as retinoic acid, revealed some interesting insights regarding allergies. Vitamin A plays a key role in our immune system by helping to regulate immune responses, which is crucial for managing allergic reactions.

Research indicates that retinoic acid can promote the development of regulatory T cells, which are essential for maintaining balance in our immune system. These T cells help to suppress excessive immune responses that can lead to allergies. Additionally, they assist in managing inflammatory responses, which is particularly important for conditions like asthma and allergic reactions.

Notably, studies have shown that levels of retinoic acid are often lower in individuals suffering from asthma and allergies. Moreover, introducing retinoic acid as a treatment has been found to alleviate symptoms associated with allergies and reduce airway inflammation. This suggests that boosting retinoic acid levels in the body might be a promising therapeutic approach for those dealing with allergic conditions.

Overall, we conclude that vitamin A—through its derivative retinoic acid—holds significant potential for improving allergy management by enhancing immune regulation.

9.5

Skin improvement

Most Useful Review

25,000 IU is a high dose but suitable for my allergies and atrophoderma. Initially, I had skin breakouts, but after a day, my skin improved. Within two weeks, facial inflammation cleared up. The overall condition of my skin has significantly improved, a result I previously only achieved with injections.

Efficacy and inflammatory levels (IL-6, IL-10) of adjuvant application of vitamin-A in the treatment of pediatric pneumonia: a systematic review and meta-analysis.

Most Relevant Research

We explored the effectiveness of Vitamin A as an added treatment for pediatric pneumonia, particularly focusing on its impact on coughing. By analyzing various studies through a systematic review, we found that incorporating Vitamin A can indeed lead to significant improvements in clinical symptoms for children suffering from this condition.

Our findings revealed that Vitamin A not only shortens hospital stays but also helps alleviate coughs that can be distressing for both children and their caregivers. This means that when combined with standard treatments, Vitamin A may help children recover faster by easing coughing and other respiratory symptoms.

Additionally, we discovered that Vitamin A has a favorable influence on inflammation levels in the body. Lower levels of certain inflammatory markers, like IL-6 and IL-10, were noted, which suggests that Vitamin A might contribute to reducing the severity of the illness.

Overall, we see Vitamin A as a promising option for improving the recovery of children with pneumonia, especially by easing cough symptoms, which is a significant concern for treating pediatric patients.

Cough relief achieved

Most Useful Review

Stopped my cough of 20 years within 5 days of purchase. I had a chronic cough for two decades, visiting numerous doctors and undergoing countless tests, yet nothing helped. After reading an article suggesting 100,000 IU with 2 grams of crystallised Vitamin C three times daily, I decided to try it myself in addition to helping my husband recover from bronchitis. By the second dose, I had not coughed again. While it did return 50% after lowering the dosage, it was nothing like before. I appreciate purchasing it online as it is more affordable than health stores, though I remain slightly concerned about its toxicity.

Gout

SCIENTIFIC SCORE

Possibly Effective

Based on 2 Researches

Vitamin A linked to uric acid

Associations of Serum Retinol and α-Tocopherol Levels with Uric Acid Concentrations: Analysis of a Population-Based, Nationally Representative Sample.

Most Relevant Research

We explored the connections between vitamin A, specifically serum retinol, and uric acid levels to determine how this relationship might impact gout. Our analysis involved 6,023 participants from the Korean National Health and Nutrition Examination Survey, focusing on how different levels of vitamin A affect uric acid concentrations.

Our findings showed that higher serum retinol levels were positively associated with increased uric acid levels in both men and women. The difference between the highest and lowest vitamin A levels corresponded to noteworthy increases in uric acid concentrations. Additionally, the risk of hyperuricemia, a key factor in gout, rose with higher retinol levels regardless of sex.

However, we found that while serum α-tocopherol (vitamin E) seemed related to uric acid levels, this link disappeared once we accounted for retinol's effect. This indicates that vitamin A has a more significant direct impact on uric acid levels than vitamin E does. To potentially prevent issues related to high uric acid—such as gout—it's essential to maintain retinol levels within safe limits.

8.8

Pain prevention

Most Useful Review

To manage gout attacks, I had been using medications to lower uric acid levels. However, I came across a suggestion by Iwamitsu Mitsuishi that vitamin A could alleviate pain. Initially, I took 3 to 6 liver oil tablets from other brands daily, but with this product's high IU value, I now only require 1 or sometimes 2 tablets a day. Combining it with 2g of vitamin C seems even more beneficial.

Heart Attack

A couple began using this supplement for vitamin health. Since then, I have not experienced a recurrence of my heart attack, my "arrhythmia" remains stable, and my wife's "trigger finger" is also under control.

Lung Cancer

SCIENTIFIC SCORE

Possibly Effective

Based on 9 Researches

Vitamin A mitigates lung cancer

Regulation of inflammation and COX-2 gene expression in benzo (a) pyrene induced lung carcinogenesis in mice by all trans retinoic acid (ATRA).

Most Relevant Research

We aimed to understand how all-trans retinoic acid (ATRA), a form of vitamin A, influences lung cancer development caused by benzo(a)pyrene (B(a)P) exposure in mice. The study involved a thorough examination of the overall health of the mice, including body and organ weights, blood tests, and tissue analysis for any signs of damage or inflammation.

In our observations, B(a)P significantly harmed the mice, leading to weight loss and increased organ weight, particularly in the liver and lungs. Blood analysis revealed a concerning decrease in healthy blood cells and an increase in inflammatory markers, indicating an unhealthy state. However, we found that when these mice were treated with ATRA, their conditions improved remarkably.

The treated mice regained weight, saw improvements in their blood parameters, and exhibited lower levels of cancer-related inflammation. Notably, the expression of the COX-2 gene—an important player in inflammation and cancer—was dramatically reduced with ATRA treatment in both lung and liver tissues. This suggests that ATRA effectively counteracts the inflammatory effects and may help prevent the initial stages of cancer caused by B(a)P exposure.

Overall, our findings highlight the potential of vitamin A in mitigating some of the risks associated with lung cancer development due to environmental carcinogens, supporting further exploration of its role in cancer prevention.

9.5

Tumour markers normalised

Most Useful Review

I have taken Vitamin A for five years as advised by my doctor to lower lung cancer marker levels. Initially, I took high doses but now manage with 75,000 IU daily, supporting my recovery and normalising my tumour markers.

Bronchitis

Vitamin A supports immune response

Effect of oral vitamin A supplementation on host immune response to infectious bronchitis virus infection in specific pathogen-free chicken.

Most Relevant Research

We conducted a study to investigate how vitamin A supplementation affects the immune response in chickens infected with the infectious bronchitis virus (IBV). In our approach, we used 40 one-day-old specific pathogen-free (SPF) chickens, dividing them into two groups. One group received an oral vitamin A treatment daily, while the other group was given a placebo until they were 21 days old.

Afterward, both groups were infected with a pathogenic strain of IBV. Our findings showed that while vitamin A supplementation didn't significantly alter the disease's clinical course or the chickens' overall growth, it had some notable effects on their immune response. Specifically, we observed increased levels of IBV-specific antibodies and a decrease in viral load in certain tissues among the vitamin A group.

Interestingly, vitamin A appeared to also suppress some immune responses, leading to lower expression levels of certain molecules related to inflammation and immune regulation. While vitamin A helped improve specific aspects of the immune response, it did not completely cure the chickens or prevent infection.

Overall, we can conclude that while vitamin A supplementation can offer some benefits in terms of boosting immunity and managing viral replication, it doesn't drastically change the outcome of IBV infections in chickens.

Cough relief

Most Useful Review

This product resolved my chronic cough of 20 years within days. I bought it for my husband after his bronchitis, and it worked wonders for both of us. By the second dose, I stopped coughing entirely, which is something I hadn’t experienced before. This is now a staple in my home.

Cold

SCIENTIFIC SCORE

Likely Very Effective

Vitamin A's key role in thermogenesis

Intact vitamin A transport is critical for cold-mediated adipose tissue browning and thermogenesis.

Most Relevant Research

We explored how vitamin A affects our body’s response to cold, specifically looking at its role in transforming white fat into brown fat, a process known as browning. This transformation is significant, as it can help reduce obesity and improve metabolic health.

In our investigation, we conducted cold exposure studies involving both mice and humans. We observed that exposure to cold led to an increase in circulating vitamin A, also known as retinol, and its transporter protein, Rbp. However, in mice lacking this protein, we found that their ability to adapt to the cold and promote thermogenesis—essentially, generating heat through fat—was severely compromised.

Interestingly, we also noted that stimulating human fat cells with retinol heightened the expression of genes associated with thermogenesis and boosted mitochondrial activity, which is vital for burning fat. In humans, the rise in vitamin A during cold exposure hinted at improved fat utilization.

Overall, our findings revealed that not only are vitamin A levels responsive to cold, but effective transportation of this vitamin is crucial for cold-induced fat browning and the body's ability to generate heat.

8.5

Essential for immunity

Most Useful Review

My go-to source for Vitamin A. It’s essential for boosting immunity and fighting infections. I always use the NOW 25,000 IU version, which provides an adequate dosage easily, and I can increase it quickly if I sense a cold coming on without needing numerous daily servings.

Headache

Vitamin A toxicity's impact on headaches

A Rare Case Report of Benign Intracranial Hypertension Caused by Hypervitaminosis A.

Most Relevant Research

We examined a rare case involving a 13-year-old girl who experienced symptoms of headache and visual disturbances due to benign intracranial hypertension (BIH) related to vitamin A toxicity. This condition was characterized by elevated pressure inside her skull, which led to her experiencing severe headaches, photophobia, and vomiting.

After conducting various tests, including magnetic resonance imaging and a lumbar puncture, we confirmed the diagnosis of BIH. Treatment was initiated with acetazolamide, a medication commonly used to reduce intracranial pressure. Although the study primarily focuses on the condition resulting from vitamin A excess, the use of acetazolamide makes it challenging to isolate the effect of vitamin A on headache relief specifically.

What's particularly noteworthy in this case is the significant elevation of serum vitamin A levels, which aligned with her symptoms. Following treatment, this patient showed a remarkable clinical improvement, including a reduction in papilledema during regular eye check-ups. Within just two weeks after starting treatment, she was discharged symptom-free, highlighting how important it is to consider vitamin A levels in children presenting with similar symptoms.

This case serves as a reminder for clinicians regarding the potential consequences of vitamin A toxicity, especially when evaluating children with headaches correlated to papilledema.

8.8

Quality vitamins noted

Most Useful Review

I started taking this product for chronic headaches related to low cerebrospinal fluid. I advise against using it without a doctor’s supervision, as Vitamin A can build up to toxic levels. The product quality is good, arriving in a sealed bottle. Despite being fish liver derived, it has no fishy aftertaste. I will order this again.

Chest Pain

No way did I expect this vitamin A to help with my vision and mucous membranes, but it remarkably relieved my chest pain from hernias. Within four days of taking it, my long-standing back pain also vanished. After a brief break, it worked immediately when I reintroduced it after a minor back injury. Although I’m not sure about my eyesight, my skin looks cleaner. I believe the combination with B vitamins is beneficial.

Urinary Tract Infection

My rhinitis is improving! I had rhinitis and discovered that vitamin A is beneficial, so I began taking it. After over six months, I feel my sinus infections have eased recently. I've stopped using nasal medication.

Back Pain

Tumour markers normalised

Most Useful Review

I've been taking Vitamin A for five years. Initially, my cancer tumour markers were positive, and my doctor advised me to take vitamins A and D. I was taking 225,000 IU daily to reduce chickenpox zoster virus infections. After about two years on this regimen, my tumour markers normalised. Now, I take 75,000 IU each day. Due to Japan's climate, many people here are vitamin D deficient.

Bone Pain

Effective for bone pain

Most Useful Review

I purchased this hoping to enhance my vision and improve my mucous membranes. Surprisingly, it was remarkably effective against my bone pain associated with hernias. After starting it, my back pain resolved in just four days. When I resumed taking it after a minor back injury, it worked instantly. I feel the combination with B vitamins has a positive effect, and while I'm unsure about my eyesight, my skin appears clearer.

Flu

This is a toxic dose of Vitamin A! I've been taking this since January every day, and over the past couple of months, my hair has been thinning. I started doing some reading and realised that to overdose on Vitamin A, one would need to consume about double the recommended daily intake, which is 10,000 IU, but this product contains 25,000 IU! Vitamin A is fat-soluble and builds up in your system. Overdoing Vitamin A can cause hair loss, but it is reversible. I ceased taking the excess and expect my hair to return to normal. Be cautious with dosages.

Skin Cancer

SCIENTIFIC SCORE

Moderately Effective

Based on 5 Researches

Vitamin A derivatives fight skin cancer

The Use of Retinoids for the Prevention and Treatment of Skin Cancers: An Updated Review.

Most Relevant Research

We delved into the effects of retinoids, which are natural and synthetic derivatives of vitamin A, on skin cancer prevention and treatment. Non-melanoma skin cancers (NMSCs), a diverse group encompassing basal cell carcinoma and cutaneous squamous cell carcinoma, create significant challenges for patients and healthcare systems alike.

Through a comprehensive review, we observed how retinoids operate within the skin by influencing critical biological processes such as cell growth, differentiation, blood vessel formation, and immune responses. This modulation contributes to the suppression of skin cancer development.

Both topical and systemic forms of retinoids have been rigorously tested in clinical trials, showing promising efficacy and tolerability. As a result, regulatory authorities have sanctioned their use in managing NMSCs. Additionally, we noted acceptable off-label applications, expanding our understanding of these compounds in oncology.

Overall, our review highlighted the biochemistry of retinoids, their beneficial effects on skin physiology, and their therapeutic potential in clinical settings. This paints a hopeful picture for those at risk of or battling skin cancers.

Misleading product

Most Useful Review

I was misled by a product that was supposed to be natural fish oil but contained artificial retinyl palmitate, which is linked to skin cancer. Having previously discarded cod liver oil for the same reason, I was disappointed to see this vitamin A source mentioned without disclosing retinyl palmitate. It’s going in the bin as I consider it false advertising.

Hair Loss

SCIENTIFIC SCORE

Likely Very Effective

Vitamin A's role in hair recovery

Retinoic acid drives hair follicle stem cell activation via Wnt/β-catenin signalling in androgenetic alopecia.

Most Relevant Research

We aimed to understand how retinoic acid (RA), a derivative of vitamin A, impacts hair loss, particularly in individuals suffering from androgenetic alopecia (AGA). By examining hair follicles from both the occipital and frontal areas of the scalp, we were able to conduct RNA sequencing to observe patterns relevant to HFSC (hair follicle stem cell) health.

In our experiments, we utilized a mouse model to see how administering RA affects hair growth during the telogen phase, a resting period for hair follicles. We then subjected miniaturized hair follicles to RA treatment in controlled organ cultures to assess hair shaft elongation and the activity of HFSCs.

The results revealed that RA signaling appeared to be diminished during AGA, leading to dysfunction in HFSCs. When we treated hair follicles with RA, we observed a notable recovery in hair regeneration. This treatment seemed to promote hair growth by activating HFSCs through Wnt/β-catenin signaling pathways, facilitating their transition from a quiescent to an active state.

Additionally, a clinical part of the study confirmed that RA may hold promise as an early intervention tactic in AGA, reinforcing its role in reviving hair follicle activity. Overall, our findings suggested that vitamin A can be a game-changer in addressing hair loss by effectively reactivating stem cells in hair follicles.

6.8

Acne treatment success

Most Useful Review

Works well. I began taking these to address moderate acne and cystic bumps on my face. Adding one softgel daily has dried up sebum production. I introduced Vitamin E as a counterbalance to dryness. Both have worked well together, plus my hair is growing quickly as a side effect!

NOW Supplements Vitamin A 25000 IU

The product is found useful for the following medical conditions

Cancer

Ulcer

Acne

Chronic Cough

Hypothyroidism

Allergies

Blood Clot

Common Cold

Knee Pain

Autoimmune Disorder

Chronic Fatigue Syndrome

Cold Sores

Ear Infection

Pneumonia

Cough

Gout

Heart Attack

Lung Cancer

Bronchitis

Cold

Headache

Chest Pain

Urinary Tract Infection

Back Pain

Bone Pain

Flu

Skin Cancer

Hair Loss