Thiamin improves memory in hypothyroidismAmeliorative effects of thiamin on learning behavior and memory dysfunction in a rat model of hypothyroidism: implication of oxidative stress and acetylcholinesterase.
Most Relevant Research
Our study focused on how thiamin, also known as Vitamin B1, can help with learning and memory issues caused by hypothyroidism. We designed an experiment using 50 rats, which we treated with propylthiouracil to induce hypothyroidism and then supplemented with varying doses of thiamin. Over a period of seven weeks, we assessed the rats’ abilities to remember and learn through standard tests like the Morris water maze and passive avoidance tasks.
We observed that thiamin significantly improved the ability of hypothyroid rats to recall the location of a hidden platform in the water maze. The rats that received higher doses of thiamin spent less time finding the platform and traveled shorter distances compared to those in the hypothyroid group who did not receive the supplement. Similarly, in the passive avoidance test, rats treated with thiamin demonstrated longer delays before entering a dark chamber, indicating improved memory retention.
Additionally, thiamin showed promise in reducing oxidative stress and decreasing acetylcholinesterase activity in the brain. This suggests that thiamin may help to rebalance certain chemicals in the brain, contributing to better memory function. Overall, our findings support the potential benefits of thiamin for addressing learning and memory deficits in cases of hypothyroidism, primarily by improving oxidative status and cholinergic function.
Eliminated fatigue
Most Useful Review
My digestive issues have vanished, and my pancreas is functioning well. I no longer experience drowsiness or constant fatigue. All signs of hypothyroidism have disappeared. I will definitely continue with this supplement.