Last update
5/3/2026
Reviewed By
Infographics
Overview
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
6.2
USERS' SCORE
Moderately Good
Based on 8 Reviews
7.9
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Thiamin(from Thiamin HCl) (Vitamin B-1)
100 mg
8,333%
Top Medical Research Studies
8
Promising pilot study supports pregnancy-safe acne therapy
Thirteen pregnant women with inflammatory acne received targeted 308-nm excimer light treatment twice weekly for eight weeks during their second trimester. The study found that inflammatory lesions decreased by an average of 48.3%, with five patients achieving significant improvement on standardized acne scales.
Treatment safety appeared reassuring: blood folate levels remained normal throughout the study, and pregnancy outcomes were positive. Patients also reported improved quality of life. These results suggest that lesion-directed excimer light may offer a pregnancy-safe alternative when traditional acne medications raise safety concerns, though larger controlled studies are needed to confirm these findings.
Treatment safety appeared reassuring: blood folate levels remained normal throughout the study, and pregnancy outcomes were positive. Patients also reported improved quality of life. These results suggest that lesion-directed excimer light may offer a pregnancy-safe alternative when traditional acne medications raise safety concerns, though larger controlled studies are needed to confirm these findings.
Read More
2
We explored how different B vitamins affect acne and other skin conditions through an examination of existing research and clinical reports. While niacinamide (B3) shows genuine promise as an effective acne treatment comparable to antibiotics, other B vitamins tell a different story. Cyanocobalamin (B12), pyridoxine (B6), and riboflavin (B2) actually made acne worse for some patients, and B12 injections triggered allergic reactions including acne in others. The takeaway: B vitamins aren't one-size-fits-all solutions. Checking for vitamin deficiencies—particularly B vitamins—should be part of standard skin care evaluation, but supplementation requires careful consideration of individual responses.
Read More
7
Nicotinamide B3 effective but underperforms IPL treatment
A split-face study with 20 acne patients compared intense pulsed light (IPL) treatment on one side against topical nicotinamide 4%—a form of vitamin B3—applied on the other side. Both approaches reduced inflammatory acne lesions over the three-month follow-up period.
However, IPL delivered noticeably better results than the nicotinamide cream, with patients reporting greater satisfaction with the light treatment. While nicotinamide showed promise as an anti-inflammatory option without systemic side effects, it appeared less effective than the device-based approach for this patient group.
However, IPL delivered noticeably better results than the nicotinamide cream, with patients reporting greater satisfaction with the light treatment. While nicotinamide showed promise as an anti-inflammatory option without systemic side effects, it appeared less effective than the device-based approach for this patient group.
Read More
Most Useful Reviews
4
Acne decreased
3 people found this helpful
I enjoy sweets and consume them frequently, so I bought this to aid sugar metabolism. I initially tried pantothenic acid but stopped due to drying effects causing dry acne. This supplement suits me better. There aren't many single nutrient supplements in Japan, so I appreciate this individual vitamin B. Since I began taking it, my acne has lessened.
Read More
8
Acne healed
2 people found this helpful
For skin and intestines I bought it for my facial skin. I frequently endure inflammation. After starting to drink it, even less than a month later, the acne and wounds that had lingered for months have passed and healed. Plus, my constipation issue was resolved.
Read More
8
Improved skin quality
2 people found this helpful
It might not work for everyone, but I've struggled with adult acne for years. I started taking Vitamin A on a whim and noticed an improvement. While it takes time, this really helped enhance my skin quality and reduce my acne. Highly recommend!
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
6.2
- All Researches
8
Promising pilot study supports pregnancy-safe acne therapy
Thirteen pregnant women with inflammatory acne received targeted 308-nm excimer light treatment twice weekly for eight weeks during their second trimester. The study found that inflammatory lesions decreased by an average of 48.3%, with five patients achieving significant improvement on standardized acne scales.
Treatment safety appeared reassuring: blood folate levels remained normal throughout the study, and pregnancy outcomes were positive. Patients also reported improved quality of life. These results suggest that lesion-directed excimer light may offer a pregnancy-safe alternative when traditional acne medications raise safety concerns, though larger controlled studies are needed to confirm these findings.
Treatment safety appeared reassuring: blood folate levels remained normal throughout the study, and pregnancy outcomes were positive. Patients also reported improved quality of life. These results suggest that lesion-directed excimer light may offer a pregnancy-safe alternative when traditional acne medications raise safety concerns, though larger controlled studies are needed to confirm these findings.
Read More
7
Nicotinamide B3 effective but underperforms IPL treatment
A split-face study with 20 acne patients compared intense pulsed light (IPL) treatment on one side against topical nicotinamide 4%—a form of vitamin B3—applied on the other side. Both approaches reduced inflammatory acne lesions over the three-month follow-up period.
However, IPL delivered noticeably better results than the nicotinamide cream, with patients reporting greater satisfaction with the light treatment. While nicotinamide showed promise as an anti-inflammatory option without systemic side effects, it appeared less effective than the device-based approach for this patient group.
However, IPL delivered noticeably better results than the nicotinamide cream, with patients reporting greater satisfaction with the light treatment. While nicotinamide showed promise as an anti-inflammatory option without systemic side effects, it appeared less effective than the device-based approach for this patient group.
Read More
7
Combination therapy outperforms metformin monotherapy for PCOS
We conducted a six-month randomized controlled trial to determine whether combining myoinositol with metformin offers additional benefits over metformin alone for polycystic ovary syndrome (PCOS). The study included 53 overweight and obese women aged 18–35, with 27 receiving metformin monotherapy and 26 receiving the combination treatment. Both treatments target insulin resistance, a key driver of PCOS symptoms.
The combination therapy proved superior, delivering additional improvements in menstrual cycle regularity and quality of life compared to metformin alone. While acne was among the measured outcomes, the study's primary focus centered on hormonal and metabolic markers rather than skin-specific effects. These findings suggest that combining these insulin-sensitizing agents may offer a more comprehensive approach to managing PCOS.
The combination therapy proved superior, delivering additional improvements in menstrual cycle regularity and quality of life compared to metformin alone. While acne was among the measured outcomes, the study's primary focus centered on hormonal and metabolic markers rather than skin-specific effects. These findings suggest that combining these insulin-sensitizing agents may offer a more comprehensive approach to managing PCOS.
Read More
7
Biotin mitigates isotretinoin's skin-hair side effects
We examined how adding biotin to isotretinoin treatment affects skin and hair in acne patients. Sixty patients received either isotretinoin alone or isotretinoin plus 10 mg daily biotin for four months, with skin and hair changes measured throughout.
Biotin supplementation made a real difference. Patients taking biotin showed improved hair health—more healthy growing hairs and fewer shedding hairs—compared to those on isotretinoin alone. Importantly, biotin prevented the significant skin dryness that occurred in the non-biotin group, maintaining better skin hydration despite the medication's drying effects.
These findings suggest that adding biotin to isotretinoin therapy can meaningfully reduce common side effects like dry skin and hair loss, making the powerful acne medication more tolerable for patients.
Biotin supplementation made a real difference. Patients taking biotin showed improved hair health—more healthy growing hairs and fewer shedding hairs—compared to those on isotretinoin alone. Importantly, biotin prevented the significant skin dryness that occurred in the non-biotin group, maintaining better skin hydration despite the medication's drying effects.
These findings suggest that adding biotin to isotretinoin therapy can meaningfully reduce common side effects like dry skin and hair loss, making the powerful acne medication more tolerable for patients.
Read More
2
We explored how different B vitamins affect acne and other skin conditions through an examination of existing research and clinical reports. While niacinamide (B3) shows genuine promise as an effective acne treatment comparable to antibiotics, other B vitamins tell a different story. Cyanocobalamin (B12), pyridoxine (B6), and riboflavin (B2) actually made acne worse for some patients, and B12 injections triggered allergic reactions including acne in others. The takeaway: B vitamins aren't one-size-fits-all solutions. Checking for vitamin deficiencies—particularly B vitamins—should be part of standard skin care evaluation, but supplementation requires careful consideration of individual responses.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 8 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
4
Acne decreased
3 people found this helpful
I enjoy sweets and consume them frequently, so I bought this to aid sugar metabolism. I initially tried pantothenic acid but stopped due to drying effects causing dry acne. This supplement suits me better. There aren't many single nutrient supplements in Japan, so I appreciate this individual vitamin B. Since I began taking it, my acne has lessened.
Read More
8
Acne healed
2 people found this helpful
For skin and intestines I bought it for my facial skin. I frequently endure inflammation. After starting to drink it, even less than a month later, the acne and wounds that had lingered for months have passed and healed. Plus, my constipation issue was resolved.
Read More
8
Improved skin quality
2 people found this helpful
It might not work for everyone, but I've struggled with adult acne for years. I started taking Vitamin A on a whim and noticed an improvement. While it takes time, this really helped enhance my skin quality and reduce my acne. Highly recommend!
Read More
9
Prevents acne
Very good! It helps prevent acne.
Read More
8
Improved skin condition
Sweet stuff! I used to be prone to acne, but since taking a lot of vitamins B1, B6, and vitamin C, even when I do have acne, it improves quickly. I've been using this product for a long time; it's cost-effective and has a lot of capacity.
Read More
Frequently Asked Questions
8
Acne improvement
My skin has improved the appearance of my acne within the first month of taking it.
8
Improved skin quality
2 people found this helpful
It might not work for everyone, but I've struggled with adult acne for years. I started taking Vitamin A on a whim and noticed an improvement. While it takes time, this really helped enhance my skin quality and reduce my acne. Highly recommend!
8
Improved skin condition
Sweet stuff! I used to be prone to acne, but since taking a lot of vitamins B1, B6, and vitamin C, even when I do have acne, it improves quickly. I've been using this product for a long time; it's cost-effective and has a lot of capacity.
4
Acne decreased
3 people found this helpful
I enjoy sweets and consume them frequently, so I bought this to aid sugar metabolism. I initially tried pantothenic acid but stopped due to drying effects causing dry acne. This supplement suits me better. There aren't many single nutrient supplements in Japan, so I appreciate this individual vitamin B. Since I began taking it, my acne has lessened.
References
- Rageh MA, Ammar AM, Mohy SM, Mohsen M, Rageh K, et al. 308-nm Excimer Light for Inflammatory Acne in Pregnancy: A Prospective Pilot Study. Photodermatol Photoimmunol Photomed. 2026;42:e70072. 10.1111/phpp.70072
- Al-Sharnoby HA, Al-Bakary RH, Nassar SO, Mesbah RAM. The Efficacy of Intense Pulsed Light Versus Topical Nicotinamide 4% in Treatment of Acne Vulgaris. Photodermatol Photoimmunol Photomed. 2025;41:e70025. 10.1111/phpp.70025
- Nazirudeen R, Sridhar S, Priyanka R, Sumathi B, Natarajan V, et al. A randomized controlled trial comparing myoinositol with metformin versus metformin monotherapy in polycystic ovary syndrome. Clin Endocrinol (Oxf). 2023;99:198. 10.1111/cen.14931
- Elgharably N, Al Abadie M, Al Abadie M, Ball PA, Morrissey H. Vitamin B group levels and supplementations in dermatology. Dermatol Reports. 2023;15:9511. 10.4081/dr.2022.9511
- Aksac SE, Bilgili SG, Yavuz GO, Yavuz IH, Aksac M, et al. Evaluation of biophysical skin parameters and hair changes in patients with acne vulgaris treated with isotretinoin, and the effect of biotin use on these parameters. Int J Dermatol. 2021;60:980. 10.1111/ijd.15485
