Nature's Way Zinc Chelate 30 mg

Zinc deficiency impacts brain function

Proteomics analysis in rats reveals convergent mechanisms between major depressive disorder and dietary zinc deficiency.

Most Relevant Research

We aimed to uncover the connection between dietary zinc deficiency and symptoms associated with major depressive disorder (MDD). In our study, we used rats fed either a zinc-adequate diet or one deficient in zinc for four weeks.

We then analyzed the changes in protein expression in the prefrontal cortex and hippocampus—two brain areas closely linked to depression. This approach allowed us to see how zinc deficiency impacts the brain at a molecular level.

Our findings revealed that significant alterations occurred in proteins related to zinc transport and mitochondrial function due to the deficiency. In particular, we saw a notable decline in the activity of complex I of the mitochondrial energy production pathway in the prefrontal cortex.

These results suggest that low zinc levels can disrupt vital brain functions, potentially contributing to the development of depressive symptoms. This highlights the importance of maintaining adequate zinc levels for mental health.

9.5

Improved mental health

Most Useful Review

This vitamin has significantly aided my battle with depression and anxiety over the past year. Taking it consistently has made an enormous difference. I highly recommend it to anyone struggling with their mental health or not feeling their best.

Cold Sores details

Zinc cream alleviates cold sores

Based on 9 Researches

A randomized clinical trial on the treatment of oral herpes with topical zinc oxide/glycine.

Most Relevant Research

We conducted a double-blind, placebo-controlled clinical trial to explore the effectiveness of a zinc oxide/glycine cream in treating cold sores caused by facial and circumoral herpes. By dividing 46 participants into two groups, one receiving the zinc treatment and the other a placebo, we aimed to measure how this formulation affected the duration and severity of cold sore symptoms.

Our results were quite promising! Participants who began using the zinc oxide/glycine cream within the first 24 hours of noticing symptoms experienced cold sore lesions that lasted only an average of 5 days, compared to 6.5 days for those on the placebo. Additionally, we noticed a significant reduction in the overall severity of their symptoms, including blistering, soreness, itching, and tingling.

As for side effects, subjects treated with the zinc cream experienced only minor and reversible issues typical of ionic zinc salt solutions. This indicates that the zinc oxide/glycine cream is not only effective but also safe for treating cold sores, presenting a valuable option for many people seeking relief from this common condition.

9.5

Effective against skin issues

Most Useful Review

Zinc acts as a powerful antioxidant, vital for immunity and skin health. It helps with cold sores and oily skin by reducing inflammation and sebum production. For colds, I combine zinc with vitamin C and have noticed significant benefits over the years; my children rarely miss school due to illness. It seems to enhance overall resistance during seasonal sickness.

Common Cold details

Zinc shortens cold duration variability

Based on 6 Researches

Quantile Treatment Effect of Zinc Lozenges on Common Cold Duration: A Novel Approach to Analyze the Effect of Treatment on Illness Duration.

Most Relevant Research

We explored how zinc lozenges affect the duration of the common cold through a detailed analysis of multiple trials. In particular, we focused on the Mossad (1996) trial involving zinc gluconate lozenges, which revealed an average reduction of cold duration by about 4.0 days. While that sounds promising, our findings through a quantile treatment effect (QTE) analysis tell a more nuanced story.

Interestingly, the QTE analysis showed that for individuals suffering from lengthy colds lasting 15 to 17 days, the zinc lozenges could shorten their illness by as much as 8 days. On the flip side, those with shorter, 2-day colds only experienced a 1-day reduction in sickness. This suggests that while zinc may help, its effectiveness varies significantly depending on the initial duration of the cold, making the overall average effect less informative than we might think.

Our examination extended to three trials that used zinc acetate lozenges, yielding a similar average reduction of around 2.7 days. However, again, those averages concealed varying effects for short and long colds, highlighting the importance of looking beyond simple averages in treatment studies.

Overall, we observed that zinc lozenges can indeed help with cold duration, but the extent of that help is very much dependent on how long a person has been suffering. This approach to understanding treatment effects through QTE analysis could have important implications not just for cold treatment but also for analyzing other health outcomes.

9.5

Easier cold recovery

Most Useful Review

Given my health issues, particularly primary immunodeficiency and dermatitis, I continually take this supplement, especially through winter. The chelated form works well for me, and I noticed that colds are easier and quicker to recover from, improving my skin condition too.

Anxiety details

Zinc may alleviate anxiety symptoms

Based on 8 Researches

A systematic review of the association between zinc and anxiety.

Most Relevant Research

We explored the connection between zinc intake and anxiety in adults through a systematic review of nine original studies. Two of these studies looked at how zinc consumption impacts anxiety, while the other seven focused on the relationship between serum zinc levels and anxiety symptoms. Our analysis included studies published in English within peer-reviewed journals, ensuring a solid foundation for understanding this potential link.

What we discovered was quite illuminating. The data indicated that individuals experiencing anxiety often had lower levels of zinc in their serum compared to those who did not suffer from anxiety. Additionally, we observed an inverse association between zinc intake and anxiety levels. This suggests that higher consumption of zinc may contribute to reduced anxiety symptoms.

In conclusion, the evidence points towards zinc playing a positive role in treating anxiety, although we acknowledge some limitations in the available studies. This means zinc supplementation could be a beneficial strategy for those looking to manage their anxiety, but more research is needed to confirm these findings and understand the underlying mechanisms better.

9.5

Reduced anxiety

Most Useful Review

This vitamin has significantly helped me with my anxiety and depression over the past year. Taking it consistently has made a considerable difference. I highly recommend this vitamin to anyone struggling with mental health or not feeling their best.

Autoimmune Disorder details

Zinc supplementation benefits MS models

Based on 6 Researches

Dietary zinc status is associated with ZnT3 (SLC30A3), IL-6 gene expressions and spinal cord tissue damage in spinal cord tissue in a cuprizone-induced rat Multiple Sclerosis model.

Most Relevant Research

We explored how dietary zinc levels influence spinal cord damage and gene expressions associated with Multiple Sclerosis (MS) using a cuprizone-induced rat model. The study included 46 adult male Wistar rats divided into five groups, with some receiving zinc supplementation while others followed a zinc-deficient diet.

After eight weeks of treatment, we found that the rats with MS symptoms showed elevated markers of tissue damage and inflammation, particularly in the groups that lacked zinc. Notably, those receiving zinc supplementation exhibited significantly reduced levels of harmful substances, bringing them back closer to control levels.

Our findings highlight zinc's protective effects in a model of MS, suggesting that incorporating zinc into treatment plans could help alleviate some symptoms associated with this autoimmune disorder. This is promising for future treatment strategies for those affected by MS.

9.5

Strengthened immunity

Most Useful Review

The best zinc! It is 100% digestible, and I noticed the results immediately after taking the first tablet. My hair and eyelashes are stronger now. Zinc is essential for the nervous system, skin, hair, nails, immunity, and eye health. I recommend it to anyone looking to improve their health.

Influenza details

Zinc may prevent influenza entry

Epipharyngeal Abrasive Therapy Down-regulates the Expression of Cav1.2: A Key Molecule in Influenza Virus Entry.

Most Relevant Research

We investigated how zinc, delivered through epipharyngeal abrasive therapy (EAT), might impact the expression of a key molecule known as Cav1.2, which plays a crucial role in allowing the influenza A virus to enter cells. The study included two groups of patients: one group that received EAT, which involved scratching the epipharyngeal mucosa with a zinc chloride-treated swab, and another group that did not receive this treatment.

By analyzing tissue samples, we observed that the levels of Cav1.2 were significantly lower in the EAT-treated patients compared to those who were not treated. In fact, the expression of Cav1.2 in the patients who underwent EAT was measured to be 4.19 times lower than in the non-treated group. This suggests that the squamous metaplasia induced by EAT might help reduce the entry of the influenza virus by down-regulating this key protein.

Our findings indicate that EAT, through its zinc content, could serve as a simple and effective method to potentially prevent influenza infection by limiting the virus's ability to enter cells.

9.5

Reduced hair loss

Most Useful Review

Zinc is vital, not produced by the body, and I'll monitor my copper levels while taking it. Zinc strengthens the immune system, has antiviral properties, and is crucial in treating infections, including influenza. Many Russians face zinc deficiency, and after three weeks of taking this supplement, my hair stopped falling out, my skin improved, and my nails became stronger.

The Effectiveness of a Dietary Supplement with Honey, Propolis, Extract, and Zinc in Children Affected by Acute Tonsillopharyngitis: An Open, Randomized, and Controlled Trial.

Most Relevant Research

This study took a closer look at the effects of a dietary supplement, PediaFlù, which includes honey, propolis, and zinc, on children suffering from acute tonsillopharyngitis, a common throat infection. We explored how well this supplement worked alongside standard care compared to standard care alone over six days.

The results were quite encouraging! We found that children who received the supplement alongside standard treatment reported lower throat pain and erythema (redness of the throat) by day six. There were also improvements in swallowing and overall throat severity scores by days four and six. Interestingly, only one child in the standard care group needed additional treatment with ibuprofen, suggesting that the supplement may help alleviate symptoms effectively.

However, it's important to note that while zinc was part of this combination treatment, the study focused on the overall effect of all components together. We couldn't isolate zinc's individual impact on tonsillitis specifically. That said, the findings point to the possibility of using this dietary supplement as a helpful adjunct in treating upper respiratory tract infections, which may reduce unnecessary antibiotic use in pediatric care.

9.5

Strengthened immunity

Most Useful Review

I suffer from chronic tonsillitis and rhinitis, so viral infections always complicate matters. Doctors often prescribe antibiotics, but I started boosting my immune system with supplements. Zinc has really helped; I take it with monolaurin, vitamin D, and Gse at the first sign of illness. Since using this combination, I haven't needed antibiotics.

Ulcer details

New treatment reduces digital dermatitis

Based on 10 Researches

Investigation on the effectiveness of a new hoof care product to sustainably reduce and prevent digital dermatitis in dairy cow herds.

Most Relevant Research

We embarked on an investigation to understand whether a new hoof care product featuring iron, zinc, and aluminum can effectively reduce and prevent digital dermatitis (DD) in dairy cows. In a controlled trial involving over 130 dairy cows, we treated one hind foot of each cow twice a week with this product while leaving the other foot untreated for comparison.

The results were revealing! Our analysis indicated that the use of the hoof care product significantly reduced the severity of DD compared to the untreated group. In fact, cows treated with the product had a much lower chance of developing lesions. The outcome showed that in the control group, the odds of having a lesion were four times higher than in the treated group, and the likelihood of experiencing an active lesion versus an inactive one was even more pronounced.

Interestingly, we also observed positive outcomes in heifers, with only one developing an active lesion in the treated group, showcasing the potential for this product to help manage and prevent DD even before these young cows enter the herd. The study indicates that the combination of ingredients in this hoof care product could be a promising alternative to traditional, harsher treatments.

While zinc is included as one of the components in the product, it's essential to note that we can't isolate its effect on ulcers from the other ingredients. Therefore, we can't definitively conclude zinc's sole effectiveness when it comes to DD treatment, but the overall findings are encouraging for improving hoof health in dairy cows.

9.5

Reduction in complications

Most Useful Review

I find that zinc is critical for health. A deficiency can disrupt bodily functions, resulting in issues like skin diseases and ulcers. It's difficult to get adequate zinc from food alone, so I often rely on supplements. Additionally, recent studies indicate that zinc is more effective than vitamin C in combating colds by halting virus progression and softening disease severity. I'm pleased with its effectiveness in managing ulcers and would recommend it wholeheartedly.

Cold details

Based on 3 Researches

Zinc’s effects on colds

Zinc for prevention and treatment of the common cold: Summary of a Cochrane review.

Most Relevant Research

We explored how zinc might help in treating and preventing the common cold. The study focused on zinc's effects, isolating it from other treatments to understand its true impact on cold symptoms. By doing this, the researchers aimed to clarify whether zinc could genuinely shorten the duration of a cold or alleviate its symptoms.

The findings were intriguing but showed that zinc might not yield significant benefits for everyone. While some individuals reported a slight reduction in cold symptoms, the evidence did not strongly support zinc as an effective treatment overall.

This means that, for those seeking relief from a nasty cold, zinc alone might not be the go-to solution we hoped it would be. It’s essential to consider this information when deciding on a cold treatment plan and to approach zinc with realistic expectations.

9.5

Prevents colds effectively

Most Useful Review

I've bought this several times and will continue to do so. Since I started taking these, I haven't had a cold.

Alzheimer details

Zinc compound shows promise in Alzheimer

Carboxylated Zn-phthalocyanine attenuates brain Aβ in AD model mouse.

Most Relevant Research

We explored how a carboxylated zinc compound, known as Zn-phthalocyanine (ZnPc), impacts Alzheimer’s disease by examining its effects on amyloid beta (Aβ) deposition in a specific mouse model. Over a 12-week period, we administered weekly injections of ZnPc to older J20 mice, carefully assessing their cognitive abilities through various behavioral tests. Early findings showed that this zinc-based treatment significantly improved learning and memory in these mice.

We found that ZnPc accumulated in the brain and effectively reduced levels of Aβ both within neurons and in surrounding areas. Notably, neuronal health appeared to improve as more neurons were observed in regions of the brain crucial for memory, like the cortex and hippocampus. The treatment also reduced harmful inflammatory responses, as indicated by fewer activated astrocytes and microglia, which are often involved in neurodegeneration.

Furthermore, improvements were noted in blood vessel integrity and overall brain structure, suggesting that ZnPc not only targets Aβ but also supports broader neurological health. In summary, our results propose that ZnPc may serve as a promising therapeutic agent for Alzheimer’s disease, emphasizing the potential of zinc and its compounds in addressing neurodegenerative issues.

8.8

Supports alzheimer treatment

Most Useful Review

Excellent zinc! This chelated form ensures maximum absorption, which is vital as zinc plays a crucial role in breaking down nutrients and cell renewal. It benefits testosterone production in men and supports women's health, including during pregnancy. Zinc also aids thyroid function, mood regulation, and memory retention. A lack of zinc can lead to various health issues, including alzheimer. To maximise benefits, take zinc after meals.

Bloating details

Wonderful! It doesn't cause stomach pain or bloating and is quickly absorbed.

Bronchitis details

Zinc accelerates bronchiolitis recovery

Zinc sulphate for acute bronchiolitis: A double-blind placebo-controlled trial.

Most Relevant Research

We investigated the effectiveness of zinc sulphate in treating acute bronchiolitis in children, aiming to uncover whether this supplement could help speed recovery. In our study, we closely examined 100 young patients diagnosed with the condition. Half of the children received oral zinc sulphate while the other half received a placebo.

Over the course of the treatment, we compared the clinical signs and symptoms between the two groups at several intervals: 24, 48, 72, 96, and 120 hours after starting. Encouragingly, we observed that those in the zinc group showed a more favorable trend in recovery compared to the placebo group across all time points. Notably, significant differences were noted in improvements of coughing and wheezing at the 48 and 72-hour marks.

Remarkably, we found that 98% of the children who received zinc sulphate achieved full recovery within 72 hours of treatment—indicating a rapid response to the therapy. Our findings suggest that zinc sulphate can notably accelerate the improvement of clinical symptoms in acute bronchiolitis. Therefore, we feel confident recommending zinc sulphate as a helpful treatment option for this condition.

9.5

Effective for coughing

Most Useful Review

Very effective for cough, particularly for those with chronic bronchitis. Unlike Russian medications, this zinc did not trigger allergies.

Cancer details

Zinc's role in cancer immunity

Based on 6 Researches

cancer cells outcompete macrophages for microenvironmental zinc to drive immunotherapy resistance.

Most Relevant Research

We explored how zinc levels impact cancer cells and immune function, particularly focusing on macrophages, which are crucial for our body’s defense against tumors. Our research revealed that cancer cells often have decreased expression of specific genes tied to immune response, and this links to resistance against therapies designed to unblock immune checkpoints.

By upregulating a zinc importer known as SLC39A9, these cancer cells manage to hoard zinc for themselves, leaving the surrounding tumor microenvironment (TME) depleted of this vital nutrient. This competition for zinc results in macrophages becoming zinc-starved, which diminishes their ability to perform essential tasks like engulfing and destroying cancer cells.

Interestingly, we found that when we replenished zinc levels in the TME—through a dietary intervention—these macrophages could regain their pro-phagocytic function. This change significantly improved the response of certain tumors to immunotherapy treatments. Notably, T cells weren’t required for this transformation, indicating that macrophages alone play a pivotal role.

Our results are clinically relevant, showing that cancer patients with reduced zinc levels in their body tend to experience worse outcomes. Overall, we identified a new mechanism by which cancer cells can disrupt immune function, highlighting zinc’s critical role in both tumor environments and immunotherapy effectiveness.

8.8

Supports cancer treatment

Most Useful Review

Good zinc! For those with zinc deficiency, especially men planning to have children, it's crucial. Zinc acts as an antioxidant that neutralises free radicals, preventing cancer, and stimulates blood production while promoting collagen synthesis for wound healing. The quality is excellent, with a high daily content, and the capsules are conveniently sized.

Chronic Fatigue Syndrome details

Zinc supplementation may benefit CFS

Lower serum zinc in Chronic Fatigue Syndrome (CFS): relationships to immune dysfunctions and relevance for the oxidative stress status in CFS.

Most Relevant Research

We explored the relationship between serum zinc levels and chronic fatigue syndrome (CFS) in a study that compared patients with CFS to normal volunteers. By using an atomic absorption method, we measured serum zinc concentrations and found that those suffering from CFS had significantly lower levels of zinc compared to healthy individuals.

Interestingly, we observed a trend indicating that lower zinc levels correlated with greater CFS severity. Patients also reported a negative correlation between their zinc levels and their subjective experiences of infection. This suggests that zinc plays a role in the immune dysfunction commonly seen in CFS.

Furthermore, we noted that lower serum zinc was associated with higher levels of inflammatory markers and certain defects in the early activation of T cells. Since zinc acts as a potent antioxidant, our findings indicate that CFS is linked to increased oxidative stress in these patients. Given this, it may be beneficial for some CFS patients to consider zinc supplements as part of their treatment approach.

8.8

Improved thyroid function

Most Useful Review

I have hypothyroidism and chronic fatigue syndrome due to iron and zinc deficiencies. This affects my health, causing symptoms like hair loss and fatigue. Zinc chelate is crucial for my thyroid function and hormone balance. It has significantly improved my life, and I take it for my family's immunity as well. This brand provides the right dosage, as recommended by my doctor.

Eczema details

Zinc enhances eczema recovery

Transient symptomatic zinc deficiency in an exclusively breastfed infant.

Most Relevant Research

We investigated the relationship between zinc deficiency and eczema in a 3-month-old infant who was exclusively breastfed. The infant presented with symptoms like scaling erythematous dermatitis affecting her face and other areas, alongside irritability and poor weight gain. Her mother had been taking isoniazid for tuberculosis during pregnancy, which possibly contributed to the infant’s zinc deficiency.

After initial treatments for a suspected skin infection didn’t bring any changes, we found that the baby had low serum zinc levels and low zinc concentration in her breast milk. This led us to believe the skin condition was due to zinc deficiency rather than an infection. We started zinc supplementation, and the infant showed remarkable improvement in her skin condition and weight.

By 6 months, the infant had begun eating solid food, and we stopped the zinc supplements, with no signs of eczema returning. This case underscores the importance of monitoring zinc levels in breastfed infants, especially when mothers are on specific medications that might impact nutrient transfer through breast milk.

9.5

Immediate effect

Most Useful Review

It’s very effective! I suffer from eczema and dandruff, and since I started taking zinc, the irritation and itching have disappeared!

Erectile Dysfunction details

Zinc improves erectile dysfunction

Effect of oral zinc therapy on gonadal function in hemodialysis patients. A double-blind study.

Most Relevant Research

We observed the effects of zinc on erectile dysfunction in a carefully designed study that involved a double-blind trial. Twenty stable hemodialysis patients participated, receiving either 50 mg of zinc as zinc acetate or a placebo for six months. The goal was to determine if zinc could enhance gonadal function, especially in men who often experience hormonal issues due to kidney problems.

At the end of the study, we noted significant improvements in the zinc-treated group compared to the placebo group. Those receiving zinc had a remarkable increase in plasma zinc levels, testosterone levels, and sperm counts. Specifically, testosterone levels rose from 2.8 to 5.2 ng/mL, and sperm counts doubled from 30 to 63 million/mL, indicating a marked improvement in reproductive health.

Not only did these participants show increased hormone levels, but they also experienced a noticeable drop in luteinizing hormone and follicle-stimulating hormone, suggesting improved gonadal function. Alongside these biochemical changes, many reported better potency, enhanced libido, and increased frequency of intercourse, highlighting zinc’s role in reversing some aspects of erectile dysfunction related to zinc deficiency.

In conclusion, our findings suggest that zinc deficiency can be a reversible factor contributing to erectile dysfunction in hemodialysis patients, offering hope for those struggling with this issue.

8.8

Vital for health

Most Useful Review

Excellent form of Zinc! It plays a crucial role in combating viral infections, especially helping with erectile dysfunction. It strengthens the immune system, detoxifies the body, and supports male reproductive health. Zinc also promotes healthy hair, nails, and skin, alleviating oily skin and acne in teenagers. A chelated form of Zinc is ideal for bioavailability and rarely causes side effects. Remember to supplement with Copper if taking Zinc long-term!

Gastritis details

Zinc protects against gastritis damage

Based on 8 Researches

Zinc supplementation alleviates oxidative stress to inhibit chronic gastritis the ROS/NF-κB pathway in a mouse model.

Most Relevant Research

We investigated how zinc supplementation impacts chronic gastritis, particularly in the context of oxidative stress and inflammation. By establishing models of inflammatory injury in C57BL/6 mice, we were able to analyze the effects of zinc on the gastric mucosa, which is crucial for maintaining digestive health.

Our findings revealed that when the mice were exposed to a compound known to induce inflammation, there was a noticeable rise in reactive oxygen species (ROS), signaling an increase in oxidative stress. This stress resulted in an uptick in certain harmful factors related to inflammation and cell death. However, when we introduced zinc as a supplement, it effectively reduced these damaging factors, alleviating inflammation and the resulting cell death in both the mouse stomach and cultured cells.

Overall, our study indicates that zinc supplementation can play a significant role in controlling inflammation and protecting against cellular damage caused by oxidative stress in chronic gastritis. By modulating the ROS/NF-κB signaling pathway, zinc demonstrates potential as a protective agent for gastric health.

8.3

Comfortable zinc intake

Most Useful Review

I suffer from atrophic gastritis and functional dyspepsia. I struggled with stomachaches from zinc, but this bisglycinate chelated zinc was recommended for those with sensitive stomachs. Now, I can take it comfortably, and I haven’t experienced the white spots on my nails since starting. If you have stomach discomfort with zinc, try zinc bisglycinate.

Hashimoto details

Zinc's link to Hashimoto's thyroiditis

Association Between Essential Trace Elements and Thyroid Antibodies in the Blood of Women with Newly Diagnosed Hashimoto's Thyroiditis.

Most Relevant Research

We explored the connection between essential trace elements, particularly zinc, and Hashimoto’s thyroiditis (HT) in women who were newly diagnosed. In this study, we looked at a group of 56 women with HT and compared them to 64 matched controls.

The results showed that women with HT had significantly lower levels of selenium, iron, and zinc in their blood compared to the controls. Interestingly, their copper levels were higher. We examined the relationships between these trace elements and thyroid autoantibodies, which can indicate the presence of autoimmune activity affecting the thyroid.

While we noted a significant correlation between lower zinc (and other elements) and higher levels of thyroid antibodies, the study did not specifically focus on zinc treatment. This means that while zinc levels appear to be linked to autoantibody levels in HT, we can't definitively state that zinc treatment will improve the condition without further dedicated research.

Overall, the study indicates that lower zinc levels in conjunction with selenium and iron deficiencies might be involved in the autoimmune response seen in Hashimoto’s thyroiditis. Thus, this provides an avenue for future exploration into zinc's role as a potential supplement for women diagnosed with this condition.

9.5

Supports Hashimoto treatment

Most Useful Review

This zinc supplement is effective. It makes me feel better and aids my Hashimoto's condition. I bought it before and would definitely buy it again.

Hypertension details

Zinc associated with blood pressure

Association Between Serum Essential Metal Elements and Blood Pressure in Children: A Cohort Study.

Most Relevant Research

We investigated how zinc levels in the body might relate to high blood pressure, especially among children. In our cohort study involving nearly 2,000 children aged 6 to 14 years in Chongqing, China, we measured various factors, including essential metal concentrations and blood pressure readings.

After analyzing the data, we found that there were positive associations between higher serum levels of zinc and blood pressure parameters. However, we noticed these effects appeared more pronounced in children aged 10 and younger, pointing to possible age-related differences. While zinc did show some impact, especially in relation to triglycerides, we did not find any significant relationship between elevated blood pressure and other essential metals, like magnesium and calcium.

Our research highlights the potentially important role that maintaining balanced zinc levels can play in cardiovascular health for children. That said, while there are connections with blood pressure, it appears that more investigation is necessary to determine the precise mechanisms at work and how these findings could lead to effective prevention strategies.

9.5

Controlled hypertension

Most Useful Review

My heart ached severely, so I took zinc alongside antibiotics, leading to a successful recovery. I even discontinued my hypertension medications. A lack of zinc can lead to palpitations and high blood pressure!

Hypothyroidism details

Zinc's uncertain role in hypothyroidism

The Effect of Some Micronutrients Multi-Supplementation on Thyroid Function, Metabolic Features and Quality of Life in Patients Treating With Levothyroxine and Vitamin D: A Double-blind, Randomized Controlled Trial.

Most Relevant Research

We conducted a study to investigate the effects of micronutrient supplementation, including zinc, on thyroid function and overall quality of life in patients with hypothyroidism. Our trial involved 104 participants who were receiving levothyroxine and vitamin D. They were randomly assigned to either a group that received a mix of essential nutrients or a placebo group over eight weeks.

We measured various health markers before and after this period, including thyroid hormone levels, cholesterol, insulin resistance, and blood pressure. Our findings suggested that the group receiving the micronutrient supplement experienced improvements in insulin resistance and overall quality of life. However, it’s important to note that the specific effects of zinc alone are somewhat difficult to isolate, as it was part of a combination of nutrients being tested.

Ultimately, while the study indicates potential benefits of micronutrient supplementation for thyroid function in hypothyroid patients, further trials are necessary to clearly define the role of zinc and other nutrients in this context.

8.8

Improved life quality

Most Useful Review

I have hypothyroidism and a zinc deficiency, resulting in various health issues. I experience hair loss, fatigue, and more. Zinc intake is crucial for thyroid function and hormone regulation. I opt for zinc chelate as its bioavailability is higher. While other medications also contribute to my treatment, zinc has significantly enhanced my quality of life. I also provide it to my family to bolster their immunity.

Insomnia details

Zinc promotes sleep in mice

Based on 3 Researches

Zinc-containing yeast extract promotes nonrapid eye movement sleep in mice.

Most Relevant Research

We explored the effects of zinc on sleep by looking at how it might help with insomnia. In our study, we gave mice a zinc-containing yeast extract and monitored their behavior and brain activity. The results were quite promising.

We found that administering zinc at doses of 40 and 80 mg/kg led to a significant increase in non-rapid eye movement (NREM) sleep. This means that the mice were not only sleeping longer but also showed less activity, which is a good indicator of effective sleep. Interestingly, we did not observe any changes in rapid eye movement (REM) sleep, a crucial sleep phase for dreaming and deep rest.

Importantly, we didn’t see any negative side effects, such as rebound insomnia, within 24 hours after treating the mice. This suggests that zinc could be a safe option for those struggling with sleep issues, unlike other mineral extracts we tested, such as manganese, iron, and copper, which did not affect locomotor activity at all.

Overall, our findings provide the first evidence that zinc has a direct role in promoting sleep, opening up exciting possibilities for new sleep supplements featuring this essential mineral.

9.5

Excellent for insomnia

Most Useful Review

An excellent product that helps eliminate insomnia and promotes deep sleep.

Irritable Bowel Syndrome details

Zinc intake may reduce IBS risk

Dietary copper, zinc, copper/zinc ratio intakes and irritable bowel syndrome risk: a large-scale prospective cohort study from UK Biobank.

Most Relevant Research

We explored the potential connection between dietary zinc intake and the risk of developing irritable bowel syndrome (IBS) through a large-scale analysis of participants from the UK Biobank. By assessing the dietary habits of 175,421 individuals who did not have IBS at the start of the study, we sought to understand how various levels of zinc, as well as copper and their ratio, might influence the onset of this troublesome condition.

Over an average follow-up period of 13.3 years, we observed that 2,240 participants were diagnosed with new-onset IBS. Notably, our findings revealed a U-shaped relationship between zinc intake and IBS incidence. For those consuming less than 10 mg of zinc per day, an increase in intake was linked to a decreased risk of IBS. Specifically, individuals taking less than 10 mg of zinc daily experienced a reduced risk with higher zinc consumption.

However, the relationship shifted for individuals who had higher intakes of copper and zinc; no significant benefits were noted when intakes reached or exceeded established thresholds. This suggests that there's a delicate balance to maintain when it comes to zinc and copper in the diet.

Importantly, subgroup analysis indicated that younger individuals, particularly those under 60, could benefit more from slight increases in zinc. Overall, our study highlights the significance of dietary management, emphasizing that reasonable zinc intake may contribute to lowering IBS risk while keeping copper and the copper/zinc ratio in a sensible range.

9.5

Gentle on stomach

Most Useful Review

Suffering from irritable bowel syndrome, I must mindful of what I take. Although this zinc is a bisglycinate chelate rather than an amino acid chelate, I found it easy on my stomach and intestines with no issues when taking 1-2 tablets daily. The quality is good, and I'm optimistic about using it based on future blood tests.

Menopause details

Zinc enhances vitamin D in menopause

Effectiveness of eight-week zinc supplementation on vitamin D status and leptin levels in a population of postmenopausal women: a double-blind randomized trial.

Most Relevant Research

We set out to understand how zinc supplementation could affect vitamin D status and leptin levels in postmenopausal women. The study involved 51 healthy postmenopausal women aged between 44 and 76 from Granada, Spain. They were divided into two groups: one receiving a zinc supplement of 50 mg daily for eight weeks and the other receiving a placebo.

Our findings revealed that zinc supplementation significantly improved vitamin D status in these women. Particularly, those who had reached menopause at a younger age saw a notable increase in their vitamin D levels after taking zinc.

Additionally, we discovered a connection between zinc and leptin levels, a hormone that regulates energy balance. Both dietary zinc intake and its plasma levels were found to be inversely related to serum leptin levels—meaning as zinc levels increased, leptin levels tended to decrease.

Overall, these results suggest that zinc supplementation may play a beneficial role during menopause by enhancing vitamin D levels and influencing leptin balance among postmenopausal women.

9.5

Family wellness

Most Useful Review

During the pandemic, doctors recommended zinc for its benefits, including supporting skin health and aiding in menopause. It's effective for acne and hair loss, and essential for overall family well-being.

Psoriasis details

Zinc conditioner benefits scalp psoriasis

Efficacy and safety of supramolecular active zinc in the treatment of scalp psoriasis: a multicentre, randomized, observed-blind, parallel-group, placebo- and active-controlled noninferiority trial.

Most Relevant Research

We delved into the effectiveness of a zinc-based hair conditioner specifically designed for treating scalp psoriasis. This study was a well-structured clinical trial involving 211 participants, where individuals were divided into three groups: those receiving the specialized zinc treatment, a placebo, and a control group given calcipotriol ointment. Remarkably, the trial was multicenter and observed-blind, which adds credibility to the findings.

Our results revealed that the zinc conditioner led to a 39% disease control rate after four weeks, compared to 25% for the placebo and 37% for the calcipotriol ointment group. This means that the zinc treatment significantly outperformed the placebo while being on par with the active control variant. In essence, those using the zinc product experienced better management of their scalp psoriasis than those using a non-active alternative.

Overall, our findings highlight that a supramolecular active zinc antidandruff formulation is not just effective for treating scalp psoriasis but also helps in maintaining results over time and potentially preventing future flare-ups. This offers a promising new avenue for patients seeking relief from this chronic condition.

9.5

Effective psoriasis treatment

Most Useful Review

I took zinc for two months after my scalp became terrible post-pregnancy, and it has since cleared up completely, putting me in remission. I continue to take it without interruption alongside selenium, omega 3, and vitamin D.

Sinusitis details

Zinc Levels and Sinusitis Effects

Comparison of serum zinc levels between patients with sinonasal neutrophilic and eosinophilic inflammatory polyposis and healthy individuals.

Most Relevant Research

We explored the connection between zinc levels and chronic rhinosinusitis, particularly focusing on patients with nasal polyps. The study involved 105 participants divided into three groups: those with eosinophilic polyps, those with neutrophilic polyps, and a control group of individuals who underwent surgery for reasons other than polyposis.

We measured the serum zinc concentrations in these groups to see if there were any significant differences. Our findings revealed that patients suffering from chronic rhinosinusitis and having neutrophilic polyps had notably lower zinc levels compared to the general population. However, the zinc levels in patients with eosinophilic polyps did not show a significant difference when compared to healthy controls.

While we saw a clear distinction in zinc levels between the neutrophilic group and the control group, the overall data suggests that zinc's role in sinusitis, especially for those with eosinophilic polyps, may not be as pronounced. As such, while zinc might contribute to inflammation in specific cases, its effectiveness as a standalone treatment for sinusitis remains uncertain.

9.5

Effective cold remedy

Most Useful Review

I began taking this at the first sign of a cold, along with vitamin C. By day three, I had no trace of a cold! As someone who suffers from sinusitis, this is remarkable. I did take it for five days, but only after meals. On the fifth day, I took a capsule on an empty stomach and unfortunately, it resulted in vomiting. Nonetheless, this is a fantastic drug! I won’t take it again soon as I still have 95 capsules left. It’s now a must-have for colds.

Flu details

Zinc treatment impacts flu virus entry

Epipharyngeal Abrasive Therapy Down-regulates the Expression of Cav1.2: A Key Molecule in Influenza Virus Entry.

Most Relevant Research

In our study, we examined how epipharyngeal abrasive therapy (EAT), which includes the use of zinc chloride, affects the expression of a key molecule known as Cav1.2. This molecule is essential for the influenza virus to enter cells, making it a crucial target in flu prevention strategies.

We compared two groups of patients: those who received EAT and those who did not. Our findings revealed that the levels of Cav1.2 were significantly lower in the EAT group, at a striking 4.19 times less than in the non-treated group. This suggests that the squamous metaplasia induced by EAT—which is a process of changing the epithelium—could be a beneficial approach to limiting flu infections.

The results of the study highlight zinc's potential indirect role in flu prevention by remarking on its contribution to lowering the expression of a critical receptor for the virus. Although we didn't isolate the effects of zinc alone, the findings indicate that treatments involving zinc, like EAT, may offer a straightforward way to help limit the impact of influenza.

9.5

Quick cold relief

Most Useful Review

My go-to remedy for sniffles! When I feel a cold or flu coming on, I take zinc with vitamin C and D3, and by the next day I'm well again. It works like a charm.

Arthritis details

Zinc alleviates arthritis symptoms

Therapeutic Dose of Zinc Aspartate and Zinc Citrate Attenuates Disease Activity Indices in Rheumatoid Arthritis.

Most Relevant Research

We explored the effects of zinc supplements—specifically zinc aspartate and zinc citrate—on reducing the symptoms of rheumatoid arthritis. In our study, we induced arthritis in male Wistar rats using a collagen-related method and then treated the rats with these zinc compounds over a four-week period. Our objective was to evaluate how these compounds could impact the disease's severity and markers associated with rheumatoid arthritis.

The results were quite promising. Both zinc aspartate and zinc citrate, administered at a therapeutic dose of 50 mg of elemental zinc per day, showed a significant reduction in the clinical symptoms associated with arthritis. Furthermore, these compounds displayed antibacterial properties against Escherichia coli, which is notable since rheumatoid arthritis patients often suffer from increased sensitivity to bacterial infections.

Importantly, we found no adverse effects on liver or kidney function in the rats that received the zinc treatment. This highlights the potential of zinc compounds not only as anti-inflammatory agents but also as preventive measures against microbial growth that can complicate rheumatoid arthritis.

8.8

Essential zinc supplement

Most Useful Review

As a rheumatoid arthritis patient, I find zinc to be one of the most crucial antioxidants. Zinc levels are often diminished in those with arthritis and other inflammatory conditions. I take 30mg in one capsule to restore my zinc levels adequately.

Asthma details

Dietary zinc may reduce asthma

Association between dietary zinc intake and asthma in overweight or obese children and adolescents: A cross-sectional analysis of NHANES.

Most Relevant Research

We explored the relationship between dietary zinc intake and asthma in overweight or obese children and adolescents. This research utilized data from the National Health and Nutrition Examination Survey, focusing on those aged 20 and younger who had both asthma and dietary zinc consumption.

Our findings indicate that there is an inverse association between zinc intake and the occurrence of asthma. In simpler terms, higher dietary zinc appears to be linked with lower asthma rates in these children. This suggests that zinc could play an important role in respiratory health, especially for kids struggling with their weight.

While our study sheds light on this potential protective effect of zinc, we recognize that the results in existing literature have been mixed. Some research indicates benefits, while other studies don’t show significant effects. Therefore, while we have uncovered a correlation worth noting, further research is required to fully understand zinc’s role in asthma management.

8.8

Improved asthma symptoms

Most Useful Review

After stopping mineral supplements and flaxseed oils, my asthma symptoms worsened. Initially, I thought the environment was to blame, but when I resumed taking Nature's Way zinc chelate 30 mg and magnesium supplements alongside the flaxseed oil, I noticed a significant improvement in my asthma. While other supplements may also contribute, I highly recommend these for asthma management.

Athlete’s Foot details

Zinc aids athlete's foot treatment

Efficacy of undecylenic acid-zinc undecylenate powder in culture positive tinea pedis.

Most Relevant Research

We explored the effectiveness of a powder containing 2% undecylenic acid and 20% zinc undecylenate for treating athlete's foot, also known as tinea pedis. In a double-blind study, 151 participants were assigned to apply either the active powder or a placebo twice daily for four weeks. The results were telling.

From the 85 patients with confirmed fungal infections, a remarkable 88% of those using the active powder had negative cultures after the treatment, compared to only 17% in the placebo group. Additionally, 80% of those on the active treatment were found to be free of fungus in KOH skin scrapings after four weeks, while only 49% of placebo users achieved this. Furthermore, we observed significant improvement in symptoms like itching, burning, erythema, and scaling, with no side effects reported.

Overall, our findings indicate that the combination of undecylenic acid and zinc may offer a robust solution for individuals suffering from athlete's foot, effectively reducing fungal presence and alleviating uncomfortable symptoms. However, it is important to note that while zinc played a role in this combination treatment, we cannot fully assess its isolated effect on its own without further studies.

8.8

Improved skin condition

Most Useful Review

It effectively improved my child's hands and feet, which were prone to skin breaks and white spots. After years of lotion failing, I discovered a vitamin deficiency. I began giving him zinc supplements, and after a few months, he needed to double the dosage due to increased sweating and peeling fingernails. The zinc helps, especially since my son is very active at school, leading to quicker loss of nutrients.

Frozen Shoulder details

I decided to try zinc as I lack it in my diet. Alongside vitamins and magnesium for my chronic lower back pain, I noticed significant improvement in about three months. I recommend combining it with vitamins B and C to help alleviate stiff shoulders.

Headache details

Zinc reduces migraine symptoms

Based on 8 Researches

Assessing the Effect of Zinc Supplementation on the Frequency of Migraine Attack, Duration, Severity, Lipid Profile and hs-CRP in Adult Women.

Most Relevant Research

We conducted a randomized, double-blind, placebo-controlled trial to explore how zinc gluconate affects migraine symptoms in women. Sixty participants, with an average age of 35, were given either 15 mg of zinc per day or a placebo for 12 weeks, allowing us to measure the impact on headache frequency, duration, and intensity.

The results were quite promising; zinc supplementation significantly reduced how often headaches occurred, shortened their duration, and decreased the severity of the migraines reported. Participants in the zinc group experienced notable improvements, as indicated by their responses to the headache severity scale and a disability assessment questionnaire.

Furthermore, we found that zinc also had a positive effect on certain health markers. The serum levels of low-density lipoprotein (LDL), total cholesterol, and high-sensitivity C-reactive protein (hs-CRP) decreased with zinc supplementation. However, we didn’t observe significant changes in triglycerides or high-density lipoprotein (HDL) levels after adjusting for baseline values.

In conclusion, zinc supplementation appears to hold beneficial effects on migraine severity and frequency, offering a potential alternative for those who seek relief from these debilitating headaches.

9.5

Supports headache relief

Most Useful Review

An excellent chelated form of zinc, well absorbed. I take one capsule daily with food during cold season. Caution: taking it on an empty stomach may cause headaches. It supports immunity and helps with acne due to zinc's anti-inflammatory effects. I take Zinc along with vitamins C and D3 to maintain my family's health. I recommend you stay healthy and happy!

Heart Disease details

Zinc benefits heart health post-cisplatin

Based on 4 Researches

Role of zinc oxide nanoparticles supplementation on alleviate side effects of cisplatin induced cardiotoxicity in rats.

Most Relevant Research

We explored the potential benefits of zinc oxide nanoparticles (ZnONPs) in preventing heart damage caused by cisplatin, a powerful chemotherapy drug known for its efficacy but also for its side effects, particularly cardiotoxicity.

In our study, rats were divided into several groups, including control groups and those receiving different doses of ZnONPs. We specifically looked at a range of health markers such as lipid levels, antioxidant activity, and inflammation in heart tissues to see how ZnONPs could help soften the impact of cisplatin on heart health.

As we gradually increased the dosage of ZnONPs to 50 mg/kg, we observed significant improvements across the various health parameters examined. Notably, at this optimal dose, the rats' heart health markers showed a remarkable recovery, aligning closely with those in the healthy control group. This suggests that ZnONPs effectively protect heart tissue from oxidative stress and inflammation associated with cisplatin treatment.

Overall, our findings highlight the promising role of zinc oxide nanoparticles in mitigating heart damage linked to cancer treatments, paving the way for further research in this arena.

Supports heart health

Most Useful Review

Good price! Zinc deficiency can negatively affect immunity and lead to issues like heart disease. This product contains well-absorbed zinc chelate, which doesn't upset the stomach. It positively influences hair and skin health and boosts immunity during autumn and winter. Those with alcoholism should take zinc, as low levels can increase cravings. This formulation includes a 30 mg dosage in easy-to-swallow capsules, making it an affordable choice for a chelated form with this dosage.

High Cholesterol details

Zinc improves cholesterol levels

Effect of Zinc Supplementation on Lipid Profile and Body Composition in Patients with Type 2 Diabetes Mellitus: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis.

Most Relevant Research

We explored how zinc supplementation affects cholesterol levels and body composition in patients with type 2 diabetes. By reviewing data from nineteen randomized controlled trials, involving 1,357 participants, we uncovered significant findings regarding lipid profiles.

Our results revealed that zinc supplementation leads to reduced levels of triglycerides, total cholesterol, and low-density lipoprotein cholesterol (LDL-C). Specifically, we noted reductions of 17.41 mg/dL in triglycerides, 19.60 mg/dL in total cholesterol, and 8.80 mg/dL in LDL-C. Furthermore, we observed an increase in high-density lipoprotein cholesterol (HDL-C) by 4.82 mg/dL, which is often termed "good" cholesterol.

While zinc appears to positively influence cholesterol levels, it's interesting to note that it did not have a significant impact on body weight. The body mass index (BMI) did show a slight decrease of 0.53 kg/m², but overall body weight remained unchanged.

In conclusion, our findings suggest that zinc supplementation could be a beneficial strategy for improving cholesterol levels in individuals with type 2 diabetes, thus contributing positively to their overall health and well-being.

Balanced mood improvement

Most Useful Review

I ordered zinc chelate, 30 mg, due to its benefits for skin, the nervous system, and the immune system. I have combination skin prone to rashes, and zinc effectively reduces this issue. After two weeks, I felt more balanced and less irritable, which I attribute to both zinc and melatonin. I chose this dosage of 30 mg for its potential benefits in sports and health. The chelate formula is better absorbed, especially with vitamin A, and it supports my overall health.

Knee Pain details

This Zinc supplement is effective and does not cause stomach pain, which is a relief for me.

Prostate Cancer details

Zinc's complex role in prostate cancer

Prostate cancer-selective anticancer action of an oxindole derivative via HO-1-mediated disruption of metabolic reprogramming.

Most Relevant Research

We explored the relationship between zinc levels and prostate cancer treatments, particularly focusing on a novel compound known as 3D. This compound showed a strong potential to target prostate cancer cells, contributing to a decrease in their proliferation rates.

Our analysis revealed that compound 3D selectively impacted key metabolic processes in prostate cancer cells by suppressing factors related to energy production, such as lactate levels. Interestingly, it also reduced the activity of transporters involved in zinc absorption while leaving those responsible for zinc export untouched.

We also found that the effectiveness of 3D could be reversed with zinc treatment, highlighting a complicated interaction between zinc and this therapeutic approach. While the compound successfully lowered zinc levels in cells and inhibited cancer growth, it is essential to note that we did not find significant benefits from zinc treatment by itself in the context of this study.

Overall, our findings suggest that targeting zinc metabolism and enhancing heme oxygenase-1 expression could be a promising strategy in prostate cancer therapy, more so than the direct application of zinc itself. The results illustrate the potential for combining innovative small molecules with an understanding of cancer metabolism in the development of treatment strategies.

9.5

Maintains prostate health

Most Useful Review

I take 30 mg of zinc daily for prostate health, recommended by an esteemed doctor in North Carolina. At nearly 67, my PSA level is a low 1.6, which I monitor yearly with my doctor. My research reinforces the importance of zinc in preserving prostate health.

Reflux details

Improving pain relief

Most Useful Review

Upon waking, I experienced pain due to reflux esophagitis. However, after starting this treatment, I am noticing significant improvement.

Rosacea details

Zinc penetrates skin in rosacea

Zinc penetration through the skin barrier in atopic dermatitis and rosacea using reflectance confocal microscopy.

Most Relevant Research

We investigated how well zinc penetrates the skin in individuals with rosacea, a common condition that affects skin barrier function. Using a non-invasive technique called reflectance confocal microscopy, we compared the skin barrier permeability between those with rosacea, atopic dermatitis, and healthy individuals.

Our results revealed that zinc penetration was greater in patients with rosacea compared to those with healthy skin. Specifically, we observed higher intensity readings of zinc at a depth of 8 micrometers in the skin of rosacea patients. This indicates that their skin barrier might be more compromised in the upper layers.

Interestingly, when comparing both conditions, we found that patients with atopic dermatitis showed greater zinc penetration at deeper layers of the skin. This suggests subtle differences in how these two conditions affect skin barriers. Overall, the findings suggest that patients with rosacea experience increased permeability in the upper layers of the skin due to weakened barrier function.

Helps inflammation

Most Useful Review

Zinc is excellent! This is my second purchase. I feel it helps with inflammation related to my rosacea and during colds. I take one capsule at night and haven’t noticed any negative effects. I'm pleased with it.

Tinnitus details

Zinc intake affects tinnitus risk

The Association between Dietary Intakes of Vitamins and Minerals with Tinnitus.

Most Relevant Research

We examined how dietary intakes of vitamins and minerals, particularly zinc, could influence the onset and presence of tinnitus, a condition characterized by phantom sounds in the ears. In a study involving nearly 3,000 participants over the age of 50, we identified cases of tinnitus to determine if their dietary habits played a role in their experience of this condition.

The findings indicated that while there were no significant associations between overall vitamin and mineral intake and existing tinnitus prevalence, zinc intake stood out in relation to developing tinnitus over time. Specifically, we observed that lower zinc consumption was linked to a 44% increased risk of experiencing tinnitus over a ten-year period.

Furthermore, we noted that iron intake also showed a significant correlation, with lower iron levels raising incident tinnitus risk by approximately 35%. These results highlight the potential importance of maintaining adequate zinc and iron levels in our diets to help reduce the risk of developing tinnitus.

8.5

Tinnitus improvement

Most Useful Review

I have noticed an improvement in my immunity and recovery from colds. My acne has also improved, along with potential prevention of prostate cancer and depression. Additionally, my blood sugar control has enhanced, and there’s been a positive effect on my male reproductive ability and taste sensitivity. Most notably, my tinnitus seems to have lessened, which has greatly improved my quality of life.

Hair Loss details

Zinc shows promise for hair loss

Based on 9 Researches

Symptom Profile of Patients With Post-COVID-19 Conditions and Influencing Factors for Recovery.

Most Relevant Research

We explored how zinc acetate hydrate impacts hair loss for patients experiencing symptoms after COVID-19. In our analysis, we looked at 120 symptomatic outpatients over 12 weeks, observing their recovery patterns and any improvements in their symptoms. The focus was on various lingering effects, including fatigue and hair loss, particularly how zinc could potentially alleviate these issues.

Our findings highlighted significant improvements in hair loss for those treated with zinc acetate hydrate at multiple checkpoints (4, 8, and 12 weeks) compared to those who did not receive this treatment. The results were statistically significant and suggested that zinc could be a useful option for those struggling with hair loss post-COVID-19.

Additionally, we noted improvements in fatigue among those receiving zinc, although this was not as pronounced at all time intervals. As a whole, our study emphasized zinc's beneficial effects, particularly for hair loss, providing promising insights for anyone dealing with these challenging post-viral symptoms.

8.8

Effective product

Most Useful Review

Great product, really helps with hair loss. I love Nature Way Zinc. I've been using this for three weeks, and it significantly aided my hair loss within a week of use, particularly due to hyperthyroidism.

Allergies details

Zinc may relieve allergy symptoms

Alleviating effect of intranasal zinc on symptoms of allergic rhinitis.

Most Relevant Research

We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.

Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.

The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.

Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.

9.5

Boosts immunity

Most Useful Review

Excellent zinc in an easily chelated form! Unlike pharmacy options, I experienced no side effects or allergies. I used to have issues with zinc-containing medications, but this chelate form suits me. I take one capsule daily, and it supports my immunity, hair, skin, thyroid, and reproductive system. No allergy issues this time! I recommend this to everyone. Remember to take copper too, as they can inhibit each other.

Anemia details

Zinc deficiency linked to anemia

Zinc Deficiency Presenting With Diverse Symptoms in a Young Patient: A Case Report.

Most Relevant Research

We explored the connection between zinc deficiency and anemia through the case of an 18-year-old woman who faced a series of health issues, including urinary tract infections and insulin dysfunction. After a thorough assessment, she was diagnosed with zinc deficiency, shedding light on how this overlooked issue can impact overall health.

What stood out to us was the rapid recovery the patient experienced after beginning oral zinc supplementation. Zinc plays a critical role in numerous bodily functions, including immune support and protein regulation. By addressing her deficiency, we observed significant improvement in her symptoms, including anemia.

The patient’s diet contained high levels of substances that were inhibiting her zinc absorption, which likely contributed to her condition. This case emphasizes the importance of recognizing zinc deficiency as a potential underlying cause for unexplained health issues, particularly anemia. Prompt diagnosis and treatment can lead to a complete turnaround in the patient's health.

By sharing this experience, we hope to raise awareness among clinicians about the vital role of zinc in managing anemia and encourage timely interventions for patients showing diverse symptoms.

8.8

Boosted immunity

Most Useful Review

Excellent! Zinc is crucial for overall health and necessary for DNA synthesis, wound healing and immune system function. I ensure my multivitamin contains zinc as it aids in treating anemia and helps maintain hormonal balance. Zinc deficiency can lead to various health issues, so I've found it beneficial, especially for older individuals, in strengthening immunity and promoting overall well-being.

Back Pain details

Zinc may boost bone density

Treatment for osteoporosis in people with beta-thalassaemia.

Most Relevant Research

We explored how zinc supplementation might help with back pain in individuals with beta-thalassaemia. The research included a randomized controlled trial with 42 participants, where some received zinc while others were given a placebo.

Results showed that zinc supplementation likely increased the bone mineral density (BMD) at the lumbar spine and hip after 12 to 18 months of treatment. This improvement in bone health could suggest potential benefits in pain relief, although the study didn’t directly measure back pain outcomes.

Even though the findings about BMD improvements are promising, we should be cautious. The trial didn't provide direct evidence on whether zinc specifically alleviates back pain. It’s essential to recognize that while we observed positive changes in bone density, interpreting this as a definitive solution for back pain would be premature.

Thus, further research is necessary to connect zinc's effects on bone health to actual pain relief in order to offer clearer guidance on its use as a treatment for back pain.

No side effects

Most Useful Review

I was unable to complete a previous zinc treatment due to severe stomach pain. This time, I chose this zinc based on reviews highlighting the absence of side effects, which has proven true. I've been taking it for a week; while I can't comment on results yet, I’ve noticed my skin is more matte and the back pain has lessened.

Bone Pain details

Skin and joint improvement

Most Useful Review

Excellent! Zinc is great for our cells, supporting prostate function, protein production, wound healing, and maintaining healthy skin. It helps my bone pain and improves the condition of bones and hair.

Chest Pain details

Zinc treatment for angina pectoris

High-dose zinc to terminate angina pectoris: a review and hypothesis for action by ICAM inhibition.

Most Relevant Research

We delved into an intriguing question: Can high doses of zinc help relieve chest pain caused by angina pectoris? Our research reviewed studies that highlight how zinc may play a role in managing this condition. Angina pectoris often results from arteriosclerosis, where the arteries become narrowed due to cholesterol buildup and other factors.

We discovered that patients with severe atherosclerosis showed promising improvements when treated with high-dose zinc. Specifically, a treatment regimen involved raising serum zinc levels significantly, resulting in symptom relief for many individuals. In one notable case, 12 out of 16 patients experienced measurable benefits, including one patient who also suffered from Raynaud's disease.

Furthermore, our analysis noted that long-term exposure to zinc in the environment correlated with reduced incidence of angina and ischemic events during exercise. Zinc appears to possess antioxidant properties, which may protect against the oxidation of LDL cholesterol, a key player in artery damage. By blocking certain inflammatory factors and promoting better circulation, zinc might enhance heart function and alleviate chest pain.

Based on these findings, we propose that zinc treatment should be considered a fundamental option in both prevention and therapy for atherosclerosis-related chest pain. This could lead to a renewed focus on restoring a healthier cardiac function among those affected by these conditions.

9.5

Joint pain relief

Most Useful Review

The quality is excellent. I used it for joint pain, which greatly improved my health. Zinc also boosts immunity and is beneficial during colds and flu. I take one pill daily and recommend it as one package lasts a month.

Liver Disease details

Zinc's Role in Liver Health

Genetic inactivation of zinc transporter SLC39A5 improves liver function and hyperglycemia in obesogenic settings.

Most Relevant Research

We focused on the connection between zinc and liver health, particularly how it may influence conditions like non-alcoholic fatty liver disease (NAFLD) and metabolic issues, including type II diabetes (T2D). Our analysis of data from a large genetics cohort revealed a significant finding: rare genetic variants that reduce the function of the zinc transporter SLC39A5 were linked to better metabolic profiles and lower T2D risk.

To delve deeper into these results, we used both laboratory and animal models. We developed mice that completely lacked SLC39A5 and observed promising outcomes. These mice showcased improved liver function and lower blood sugar levels after being subjected to obesity challenges, whether congenital or diet-induced.

Notably, this improvement seemed to be associated with increased levels of zinc in the liver, which activated key signaling pathways involved in metabolism, such as AMPK and AKT. Furthermore, these mice exhibited less liver inflammation and fibrosis in models of diet-induced non-alcoholic steatohepatitis (NASH).

Together, these findings position SLC39A5 as a potentially valuable target for treating liver-related metabolic disorders, emphasizing zinc's crucial role in managing liver health and blood sugar regulation.

Supports heart health

Most Useful Review

I purchase this zinc for my semba. Zinc supports heart function, lowers the risk of cardiovascular diseases and atherosclerosis, and aids in maintaining the health of the liver, pancreas, and thyroid gland.

Migraine details

Zinc reduces migraine symptoms

Assessing the Effect of Zinc Supplementation on the Frequency of Migraine Attack, Duration, Severity, Lipid Profile and hs-CRP in Adult Women.

Most Relevant Research

This study was designed as a randomized double-blind, placebo-controlled trial to examine how zinc gluconate supplementation might alleviate migraine symptoms in adult women. We followed 60 women, averaging about 35 years old, who either received 15 mg of zinc per day or a placebo for a duration of 12 weeks.

Over the trial, we observed significant improvements in those taking zinc. The frequency of migraine attacks, as well as the duration and severity of the headaches, drastically decreased for participants receiving zinc. We used various assessments, such as a numerical rating scale and the Migraine Disability Assessment test, to evaluate these changes.

Additionally, zinc supplementation showed a notable reduction in levels of low-density lipoprotein (LDL) cholesterol and high-sensitivity C-reactive protein (hs-CRP), both of which are associated with inflammation. However, no significant changes in triglycerides or high-density lipoprotein (HDL) levels were seen. After taking initial values into account, the changes in lipid levels and hs-CRP weren’t significant.

Overall, we found that zinc supplementation can beneficially impact migraine symptoms, reducing their severity and frequency among women. This offers a promising direction for migraine management without the side effects often associated with traditional medications.

8.8

Migraine-free product

Most Useful Review

No more migraines—this product is wonderful!

Diabetes details

Zinc alleviates diabetic muscle atrophy

Zinc Alleviates Diabetic Muscle Atrophy via Modulation of the SIRT1/FoxO1 Autophagy Pathway Through GPR39.

Most Relevant Research

Our investigation aimed to understand how zinc affects muscle atrophy in diabetes, a serious complication that leads to muscle loss. Using diabetes-induced mice, we treated them with zinc sulfate for six weeks and observed notable improvements in their muscle condition.

We conducted various analyses to evaluate the impact of zinc on autophagy—the process that helps manage muscle mass. The results were promising; zinc appeared to enhance muscle recovery by regulating specific molecular pathways connected to muscle health.

Additionally, our in vitro studies with diabetic muscle cells revealed similar results, with zinc supplementation proving beneficial in reducing excessive autophagy. Overall, this suggests that incorporating zinc into treatment plans could be a promising approach to counteract muscle deterioration in diabetic patients.

8.8

Immune system support

Most Useful Review

Zinc is essential for DNA synthesis, wound healing, and hormonal balance. It's crucial for proper immune function and can help prevent colds and other infections. Zinc deficiency can lead to frequent illnesses and has been linked to diabetes. Older adults often suffer from insufficient zinc, which can impact healing and immunity. It’s vital for overall health and well-being.

Cardiovascular Disease details

Zinc counters heart cell injury

Zn protects H9C2 cardiomyocytes by alleviating MAMs-associated apoptosis and calcium signaling dysregulation.

Most Relevant Research

We set out to investigate how zinc might help protect heart cells from damage caused by a lack of blood flow, known as myocardial ischemia-reperfusion injury (MIRI). Using H9C2 cells, which are derived from rat heart tissue, we simulated this injury by depriving these cells of oxygen and then reintroducing it while treating them with zinc.

Through this process, we found that zinc treatment significantly increased cell viability compared to those that did not receive zinc. Cells exposed to ischemia showed typical signs of trauma, like heightened levels of apoptosis—or programmed cell death—and calcium overload, which can further damage cells.

Interestingly, zinc seemed to tackle these issues by lowering the levels of certain proteins related to cell death. It also played a role in regulating calcium levels by interacting with various cellular pathways. In fact, when we silenced specific proteins involved in these pathways, the protective benefits of zinc were even more pronounced.

Our findings suggest that zinc can relieve the harmful effects of ischemia by mitigating cell death and regulating calcium overload, which offers hope for future treatments for heart-related conditions impacted by blood flow interruptions.

9.5

Prostate support

Most Useful Review

I purchased "Zinc Chelate" capsules for my husband to support his cardiovascular system and prostate health. I later took them to help stabilise my blood sugar levels. We are pleased with the results and highly recommend it to older adults as it effectively supports the body, including in tackling cardiovascular disease.

Chronic Cough details

I usually ordered different brands of zinc picolinate, but when they became unavailable, I found this one. I bought five packs as the chelated form is highly digestible and the dosage is excellent. It effectively prevents colds—whenever I feel the onset of sore throat and runny nose, I take two tablets daily for two to three days, and I recover quickly. With Covid, it’s advised to take 50-100 mg daily.

Constipation details

Zinc may mitigate granisetron constipation

Carbon monoxide contributes to the constipating effects of granisetron in rat colon.

Most Relevant Research

We investigated how zinc might play a role in alleviating the constipation effects caused by granisetron, a medication often used to prevent nausea. In the studies, male rats were treated with varying doses of granisetron, alongside zinc protoporphyrin IX (ZnPPIX), to see how these compounds interacted.

Interestingly, while granisetron was found to increase the time to first defecation in the rats, ZnPPIX alone did not have a notable effect on constipation. However, when combined with granisetron, ZnPPIX successfully reversed the constipation induced by this medication. This suggests that zinc, acting through the heme oxygenase/carbon monoxide (HO/CO) pathway, could potentially mitigate constipation.

Nonetheless, it’s crucial to note that ZnPPIX’s effectiveness was only observed when paired with granisetron; its standalone administration didn’t significantly alter gastrointestinal motility. This highlights a specific interaction rather than a general benefit of zinc in treating constipation.

9.5

No constipation noted

Most Useful Review

Great supplement that doesn't cause constipation.

Heartburn details

Zinc's role in heartburn relief

Esophageal ulcer related to zinc deficiency following a total gastrectomy.

Most Relevant Research

We investigated how zinc affects heartburn through the case of a 76-year-old Japanese man who experienced significant discomfort after undergoing a total gastrectomy. For two weeks, he suffered from a sore throat, heartburn, and difficulty swallowing. Endoscopy revealed deep, craterlike ulcers in his esophagus, but tests for viral infections were negative.

After initial treatment, his symptoms returned, prompting further investigation. Eventually, we found that his serum zinc level was low at 38 µg/dL, which led to a diagnosis of zinc deficiency. Following oral zinc supplementation, the patient reported relief from his symptoms and a noticeable improvement in the esophageal ulcers observed during a follow-up endoscopy.

Over the five years since his treatment, the patient has continued to take zinc supplements and has not faced similar issues again. This case suggests that zinc can play a crucial role in treating heartburn issues related to ulcers, especially in those with a deficiency.

9.5

No heartburn experienced

Most Useful Review

This is not my first time ordering this zinc. I appreciate the value for money and its chelated form, which the body absorbs well. It helps with my initial ailments. I had no heartburn when taking it, unlike with another brand. The capsules are a suitable size and easy to swallow. I will continue to order this zinc in future.

Nausea details

Zinc treatment reduces nausea risk

Based on 4 Researches

Randomized, multicenter, active-controlled open-label study of NPC-25, zinc histidine hydrate, (non-inferiority to NOBELZIN™, zinc acetate dihydrate) for patients with hypozincemia.

Most Relevant Research

We conducted a study to evaluate how effective NPC-25, a new form of zinc, is compared to a well-known treatment, NOBELZIN™, for patients with low zinc levels. Participants in this trial had their zinc levels checked and were grouped to receive either NPC-25 or NOBELZIN™.

For a period of up to 24 weeks, we aimed to maintain their zinc levels within a specific target range while closely monitoring for side effects. One of our main goals was to see if NPC-25 could maintain these target zinc levels similarly to NOBELZIN™.

Our findings revealed that NPC-25 was indeed non-inferior to NOBELZIN™, meaning it worked just as well. Importantly, we also observed that those taking NPC-25 reported fewer digestive issues, like nausea and vomiting. This suggests that while both treatments were effective, NPC-25 might be the gentler option.

9.5

Nausea prevention advice

Most Useful Review

This zinc only contains the chelated form, which avoids nausea that often occurs with other types. I always take it post-meal to prevent nausea or stomach pain, which can happen on an empty stomach. I have had no adverse effects with this product.

Food Poisoning details

Zinc oxide combats foodborne pathogens

Based on 3 Researches

Active Packaging of Immobilized Zinc Oxide Nanoparticles Controls Campylobacter jejuni in Raw Chicken Meat.

Most Relevant Research

We set out to explore how zinc oxide nanoparticles (ZnO NPs) could help control the bacteria responsible for food poisoning in raw chicken meat. Our approach involved integrating these nanoparticles into packaging materials to see if they could effectively inactivate Campylobacter jejuni, a common and concerning pathogen in poultry.

Through our experiments, we discovered that immobilizing ZnO NPs in functional pads placed under raw chicken could dramatically reduce bacterial counts. In fact, we saw a reduction from about 4 log CFU to an undetectable level within just three days when storing chicken at 4°C. Notably, we monitored zinc levels in the chicken meat, confirming a safe release of zinc without any migration of nanoparticles onto the food. This means that we can help keep raw chicken safe and fresh without compromising its integrity or quality.

Not only did we find that these functional pads inactivated the harmful bacteria, but we also noted a related increase in lactic acid production, which plays a role in further protecting the meat. Our findings open up new avenues for using zinc in food packaging, offering a way to enhance food safety without directly adding chemicals to the food itself. Overall, this study highlights the potential for nanotechnology to play a significant role in managing foodborne pathogens like Campylobacter in poultry products.

3.5

Mild nausea noted

Most Useful Review

Unfortunately, this zinc did not suit me. I experienced mild nausea after ingestion. I previously used Zinc Glycinate from Now Foods, and this seemed even worse for me.

Diarrhea details