Nature&#039;s Way Zinc Chelate

Zinc deficiency impacts brain function

Gąsior Ł, Pochwat B, Zaręba-Kozioł M, Włodarczyk J, Grabrucker AM, et al. Proteomics analysis in rats reveals convergent mechanisms between major depressive disorder and dietary zinc deficiency. Pharmacol Rep. 2025;77:145. doi:10.1007/s43440-024-00681-7

We aimed to uncover the connection between dietary zinc deficiency and symptoms associated with major depressive disorder (MDD). In our study, we used rats fed either a zinc-adequate diet or one deficient in zinc for four weeks.

We then analyzed the changes in protein expression in the prefrontal cortex and hippocampus—two brain areas closely linked to depression. This approach allowed us to see how zinc deficiency impacts the brain at a molecular level.

Our findings revealed that significant alterations occurred in proteins related to zinc transport and mitochondrial function due to the deficiency. In particular, we saw a notable decline in the activity of complex I of the mitochondrial energy production pathway in the prefrontal cortex.

These results suggest that low zinc levels can disrupt vital brain functions, potentially contributing to the development of depressive symptoms. This highlights the importance of maintaining adequate zinc levels for mental health.

Improved mental health

Most Useful Review

102 people found this helpful

This vitamin has significantly aided my battle with depression and anxiety over the past year. Taking it consistently has made an enormous difference. I highly recommend it to anyone struggling with their mental health or not feeling their best.

Eye Infection details

Perfectly! I take one capsule every two days with vitamin D3 and vitamin C. Zinc is vital for skin, hair, and nails. It aids in skin cell rejuvenation and collagen formation, keeping the skin youthful and preventing wrinkles. Additionally, it boosts immunity against infections and plays a role in bone tissue formation. Zinc is also crucial for cognitive function and is linked to improved concentration and memory. Furthermore, it supports reproductive health and strengthens vision by helping absorb vitamin A, vital for eye function. Without it, conditions like cataracts may develop.

Psoriasis details

Zinc conditioner benefits scalp psoriasis

Yu C, Yu N, Jiang X, Gao X, Lv S, et al. Efficacy and safety of supramolecular active zinc in the treatment of scalp psoriasis: a multicentre, randomized, observed-blind, parallel-group, placebo- and active-controlled noninferiority trial. Clin Exp Dermatol. 2023;48:1138. doi:10.1093/ced/llad168

We delved into the effectiveness of a zinc-based hair conditioner specifically designed for treating scalp psoriasis. This study was a well-structured clinical trial involving 211 participants, where individuals were divided into three groups: those receiving the specialized zinc treatment, a placebo, and a control group given calcipotriol ointment. Remarkably, the trial was multicenter and observed-blind, which adds credibility to the findings.

Our results revealed that the zinc conditioner led to a 39% disease control rate after four weeks, compared to 25% for the placebo and 37% for the calcipotriol ointment group. This means that the zinc treatment significantly outperformed the placebo while being on par with the active control variant. In essence, those using the zinc product experienced better management of their scalp psoriasis than those using a non-active alternative.

Overall, our findings highlight that a supramolecular active zinc antidandruff formulation is not just effective for treating scalp psoriasis but also helps in maintaining results over time and potentially preventing future flare-ups. This offers a promising new avenue for patients seeking relief from this chronic condition.

Effective psoriasis treatment

Most Useful Review

I took zinc for two months after my scalp became terrible post-pregnancy, and it has since cleared up completely, putting me in remission. I continue to take it without interruption alongside selenium, omega 3, and vitamin D.

Adrenal Gland Disorder details

This chelated zinc is fantastic! It has significantly improved my adrenal gland disorder by providing support for my adrenal fatigue. I’ve noticed that it benefits both my adrenals and thyroid, aiding in the balance of cortisol levels.

Bronchitis details

Zinc accelerates bronchiolitis recovery

Mahyar A, Ayazi P, Ahmadi NK, Pour Nikoo ST, Hamzehloo S, et al. Zinc sulphate for acute bronchiolitis: A double-blind placebo-controlled trial. Infez Med. 2016;24:331.

We investigated the effectiveness of zinc sulphate in treating acute bronchiolitis in children, aiming to uncover whether this supplement could help speed recovery. In our study, we closely examined 100 young patients diagnosed with the condition. Half of the children received oral zinc sulphate while the other half received a placebo.

Over the course of the treatment, we compared the clinical signs and symptoms between the two groups at several intervals: 24, 48, 72, 96, and 120 hours after starting. Encouragingly, we observed that those in the zinc group showed a more favorable trend in recovery compared to the placebo group across all time points. Notably, significant differences were noted in improvements of coughing and wheezing at the 48 and 72-hour marks.

Remarkably, we found that 98% of the children who received zinc sulphate achieved full recovery within 72 hours of treatment—indicating a rapid response to the therapy. Our findings suggest that zinc sulphate can notably accelerate the improvement of clinical symptoms in acute bronchiolitis. Therefore, we feel confident recommending zinc sulphate as a helpful treatment option for this condition.

Effective for coughing

Most Useful Review

Very effective for cough, particularly for those with chronic bronchitis. Unlike Russian medications, this zinc did not trigger allergies.

Gastritis details

Zinc protects against gastritis damage

Based on 8 Researches

Sun X, Xu S, Liu T, Wu J, Yang J, et al. Zinc supplementation alleviates oxidative stress to inhibit chronic gastritis the ROS/NF-κB pathway in a mouse model. Food Funct. 2024;15:7136. doi:10.1039/d4fo01142b

We investigated how zinc supplementation impacts chronic gastritis, particularly in the context of oxidative stress and inflammation. By establishing models of inflammatory injury in C57BL/6 mice, we were able to analyze the effects of zinc on the gastric mucosa, which is crucial for maintaining digestive health.

Our findings revealed that when the mice were exposed to a compound known to induce inflammation, there was a noticeable rise in reactive oxygen species (ROS), signaling an increase in oxidative stress. This stress resulted in an uptick in certain harmful factors related to inflammation and cell death. However, when we introduced zinc as a supplement, it effectively reduced these damaging factors, alleviating inflammation and the resulting cell death in both the mouse stomach and cultured cells.

Overall, our study indicates that zinc supplementation can play a significant role in controlling inflammation and protecting against cellular damage caused by oxidative stress in chronic gastritis. By modulating the ROS/NF-κB signaling pathway, zinc demonstrates potential as a protective agent for gastric health.

Comfortable zinc intake

Most Useful Review

1 people found this helpful

I suffer from atrophic gastritis and functional dyspepsia. I struggled with stomachaches from zinc, but this bisglycinate chelated zinc was recommended for those with sensitive stomachs. Now, I can take it comfortably, and I haven’t experienced the white spots on my nails since starting. If you have stomach discomfort with zinc, try zinc bisglycinate.

Influenza details

Nishi K, Yoshimoto S, Nishi S, Nishi T, Nishi R, et al. Epipharyngeal Abrasive Therapy Down-regulates the Expression of Cav1.2: A Key Molecule in Influenza Virus Entry. In Vivo. 2022;36:2357. doi:10.21873/invivo.12967

Zinc may prevent influenza entry

We investigated how zinc, delivered through epipharyngeal abrasive therapy (EAT), might impact the expression of a key molecule known as Cav1.2, which plays a crucial role in allowing the influenza A virus to enter cells. The study included two groups of patients: one group that received EAT, which involved scratching the epipharyngeal mucosa with a zinc chloride-treated swab, and another group that did not receive this treatment.

By analyzing tissue samples, we observed that the levels of Cav1.2 were significantly lower in the EAT-treated patients compared to those who were not treated. In fact, the expression of Cav1.2 in the patients who underwent EAT was measured to be 4.19 times lower than in the non-treated group. This suggests that the squamous metaplasia induced by EAT might help reduce the entry of the influenza virus by down-regulating this key protein.

Our findings indicate that EAT, through its zinc content, could serve as a simple and effective method to potentially prevent influenza infection by limiting the virus's ability to enter cells.

Reduced hair loss

Most Useful Review

Zinc is vital, not produced by the body, and I'll monitor my copper levels while taking it. Zinc strengthens the immune system, has antiviral properties, and is crucial in treating infections, including influenza. Many Russians face zinc deficiency, and after three weeks of taking this supplement, my hair stopped falling out, my skin improved, and my nails became stronger.

Irritable Bowel Syndrome details

Zinc intake may reduce IBS risk

Zhuang Y, Li L, Ran Y, Zhang Y, Chen J, et al. Dietary copper, zinc, copper/zinc ratio intakes and irritable bowel syndrome risk: a large-scale prospective cohort study from UK Biobank. Am J Epidemiol. 2024. doi:10.1093/aje/kwae412

We explored the potential connection between dietary zinc intake and the risk of developing irritable bowel syndrome (IBS) through a large-scale analysis of participants from the UK Biobank. By assessing the dietary habits of 175,421 individuals who did not have IBS at the start of the study, we sought to understand how various levels of zinc, as well as copper and their ratio, might influence the onset of this troublesome condition.

Over an average follow-up period of 13.3 years, we observed that 2,240 participants were diagnosed with new-onset IBS. Notably, our findings revealed a U-shaped relationship between zinc intake and IBS incidence. For those consuming less than 10 mg of zinc per day, an increase in intake was linked to a decreased risk of IBS. Specifically, individuals taking less than 10 mg of zinc daily experienced a reduced risk with higher zinc consumption.

However, the relationship shifted for individuals who had higher intakes of copper and zinc; no significant benefits were noted when intakes reached or exceeded established thresholds. This suggests that there's a delicate balance to maintain when it comes to zinc and copper in the diet.

Importantly, subgroup analysis indicated that younger individuals, particularly those under 60, could benefit more from slight increases in zinc. Overall, our study highlights the significance of dietary management, emphasizing that reasonable zinc intake may contribute to lowering IBS risk while keeping copper and the copper/zinc ratio in a sensible range.

Gentle on stomach

Most Useful Review

Suffering from irritable bowel syndrome, I must mindful of what I take. Although this zinc is a bisglycinate chelate rather than an amino acid chelate, I found it easy on my stomach and intestines with no issues when taking 1-2 tablets daily. The quality is good, and I'm optimistic about using it based on future blood tests.

Low Libido details

Increased libido noted

Excellent zinc! Very good shape and dosage at a great price! Zinc is vital for our bodies, aiding in the fight against viruses and colds. When feeling unwell, I recommend a double dose, especially with vitamin D and C. My husband has noticed an increase in libido since starting it. A beneficial supplement indeed! If you find this helpful, please like! Enjoy life with zinc!

Sinusitis details

Zinc Levels and Sinusitis Effects

Ghazizadeh M, Roshanaie E, Barati B. Comparison of serum zinc levels between patients with sinonasal neutrophilic and eosinophilic inflammatory polyposis and healthy individuals. Immun Inflamm Dis. 2024;12:e70016. doi:10.1002/iid3.70016

We explored the connection between zinc levels and chronic rhinosinusitis, particularly focusing on patients with nasal polyps. The study involved 105 participants divided into three groups: those with eosinophilic polyps, those with neutrophilic polyps, and a control group of individuals who underwent surgery for reasons other than polyposis.

We measured the serum zinc concentrations in these groups to see if there were any significant differences. Our findings revealed that patients suffering from chronic rhinosinusitis and having neutrophilic polyps had notably lower zinc levels compared to the general population. However, the zinc levels in patients with eosinophilic polyps did not show a significant difference when compared to healthy controls.

While we saw a clear distinction in zinc levels between the neutrophilic group and the control group, the overall data suggests that zinc's role in sinusitis, especially for those with eosinophilic polyps, may not be as pronounced. As such, while zinc might contribute to inflammation in specific cases, its effectiveness as a standalone treatment for sinusitis remains uncertain.

Effective cold remedy

Most Useful Review

5 people found this helpful

I began taking this at the first sign of a cold, along with vitamin C. By day three, I had no trace of a cold! As someone who suffers from sinusitis, this is remarkable. I did take it for five days, but only after meals. On the fifth day, I took a capsule on an empty stomach and unfortunately, it resulted in vomiting. Nonetheless, this is a fantastic drug! I won’t take it again soon as I still have 95 capsules left. It’s now a must-have for colds.

Sore Throat details

Zinc reduces postoperative sore throat

Based on 9 Researches

Sarkar T, Mandal T. Preoperative oral zinc tablet decreases incidence of postoperative sore throat. Indian J Anaesth. 2020;64:409. doi:10.4103/ija.IJA_959_19

We investigated the impact of dispersible zinc tablets on postoperative sore throat (POST) experienced by patients after endotracheal intubation. In our study, 88 patients were divided into two groups. One group received a 40 mg zinc tablet, while the other received a placebo 30 minutes before their surgery.

Our findings revealed that the zinc group reported significantly fewer instances of POST at the 4-hour mark compared to the placebo group. Specifically, only 6.8% of patients in the zinc group experienced POST, while a higher 31.8% in the placebo group did. Furthermore, none of the patients taking zinc reported severe sore throat, a stark contrast to three patients in the placebo group who did.

Additionally, we noted lower severity ratings for sore throat in the zinc group at various time intervals post-surgery. The results emphasize that taking zinc tablets before surgery can effectively mitigate the incidence and discomfort of sore throat following intubation, presenting a simple solution for a common postoperative issue.

Daily supplement usage

Most Useful Review

6 people found this helpful

Excellent for colds, especially sore throat. I take zinc nearly every day to boost my immunity, skin, and heart health. I enjoy alternating between zinc capsules and lozenges. When I’m unwell, these lozenges lift my spirits and aid recovery. Always take zinc after meals to avoid nausea!

Swollen Lymph Nodes details

10 people found this helpful

Good value for money. This is my second time ordering zinc. This time, I took two containers at once due to a promotion. I really like the chelated form; it is the best for zinc absorption. My husband and I take it together. My PMS has significantly improved. I used to experience unreal swelling for five days before. Now, the swelling has subsided and my overall health feels much better. I recommend it!

Tonsillitis details

Zinc in supplement reduces tonsillitis symptoms

Cardinale F, Barattini DF, Martinucci V, Bordea MM, Barattini L, et al. The Effectiveness of a Dietary Supplement with Honey, Propolis, Extract, and Zinc in Children Affected by Acute Tonsillopharyngitis: An Open, Randomized, and Controlled Trial. Pharmaceuticals (Basel). 2024;17. doi:10.3390/ph17060804

This study took a closer look at the effects of a dietary supplement, PediaFlù, which includes honey, propolis, and zinc, on children suffering from acute tonsillopharyngitis, a common throat infection. We explored how well this supplement worked alongside standard care compared to standard care alone over six days.

The results were quite encouraging! We found that children who received the supplement alongside standard treatment reported lower throat pain and erythema (redness of the throat) by day six. There were also improvements in swallowing and overall throat severity scores by days four and six. Interestingly, only one child in the standard care group needed additional treatment with ibuprofen, suggesting that the supplement may help alleviate symptoms effectively.

However, it's important to note that while zinc was part of this combination treatment, the study focused on the overall effect of all components together. We couldn't isolate zinc's individual impact on tonsillitis specifically. That said, the findings point to the possibility of using this dietary supplement as a helpful adjunct in treating upper respiratory tract infections, which may reduce unnecessary antibiotic use in pediatric care.

Strengthened immunity

Most Useful Review

I suffer from chronic tonsillitis and rhinitis, so viral infections always complicate matters. Doctors often prescribe antibiotics, but I started boosting my immune system with supplements. Zinc has really helped; I take it with monolaurin, vitamin D, and Gse at the first sign of illness. Since using this combination, I haven't needed antibiotics.

Ulcer details

Hayashi A, Taki Y, Arai K, Sato S, Higashizono K, et al. Esophageal ulcer related to zinc deficiency following a total gastrectomy. Nutrition. 2023;110:111999. doi:10.1016/j.nut.2023.111999

Based on 16 Researches

Zinc helps heal esophageal ulcers

We delved into an interesting case of a 76-year-old man who developed severe esophageal ulcers, likely due to zinc deficiency following a total gastrectomy. His symptoms included sore throat, heartburn, and difficulty swallowing.

After the diagnosis of zinc deficiency, he began oral zinc treatment. Remarkably, this led to significant symptom relief and visible healing of the ulcers during follow-up imaging. Impressively, he has maintained his zinc supplementation for five years without any recurrence of symptoms. This unique case shines a light on the potential role of zinc in ulcer healing.

Reduction in complications

Most Useful Review

18 people found this helpful

I find that zinc is critical for health. A deficiency can disrupt bodily functions, resulting in issues like skin diseases and ulcers. It's difficult to get adequate zinc from food alone, so I often rely on supplements. Additionally, recent studies indicate that zinc is more effective than vitamin C in combating colds by halting virus progression and softening disease severity. I'm pleased with its effectiveness in managing ulcers and would recommend it wholeheartedly.

Alzheimer details

Zinc compound shows promise in Alzheimer

Wang R, Azad AK, Sheikh AM, Tabassum S, Zhang Y, et al. Carboxylated Zn-phthalocyanine attenuates brain Aβ in AD model mouse. Brain Res. 2025;1850:149422. doi:10.1016/j.brainres.2024.149422

We explored how a carboxylated zinc compound, known as Zn-phthalocyanine (ZnPc), impacts Alzheimer’s disease by examining its effects on amyloid beta (Aβ) deposition in a specific mouse model. Over a 12-week period, we administered weekly injections of ZnPc to older J20 mice, carefully assessing their cognitive abilities through various behavioral tests. Early findings showed that this zinc-based treatment significantly improved learning and memory in these mice.

We found that ZnPc accumulated in the brain and effectively reduced levels of Aβ both within neurons and in surrounding areas. Notably, neuronal health appeared to improve as more neurons were observed in regions of the brain crucial for memory, like the cortex and hippocampus. The treatment also reduced harmful inflammatory responses, as indicated by fewer activated astrocytes and microglia, which are often involved in neurodegeneration.

Furthermore, improvements were noted in blood vessel integrity and overall brain structure, suggesting that ZnPc not only targets Aβ but also supports broader neurological health. In summary, our results propose that ZnPc may serve as a promising therapeutic agent for Alzheimer’s disease, emphasizing the potential of zinc and its compounds in addressing neurodegenerative issues.

7.5

Supports alzheimer treatment

Most Useful Review

1 people found this helpful

Excellent zinc! This chelated form ensures maximum absorption, which is vital as zinc plays a crucial role in breaking down nutrients and cell renewal. It benefits testosterone production in men and supports women's health, including during pregnancy. Zinc also aids thyroid function, mood regulation, and memory retention. A lack of zinc can lead to various health issues, including alzheimer. To maximise benefits, take zinc after meals.

Erectile Dysfunction details

Mahajan SK, Abbasi AA, Prasad AS, Rabbani P, Briggs WA, et al. Effect of oral zinc therapy on gonadal function in hemodialysis patients. A double-blind study. Ann Intern Med. 1982;97:357.

Zinc improves erectile dysfunction

We observed the effects of zinc on erectile dysfunction in a carefully designed study that involved a double-blind trial. Twenty stable hemodialysis patients participated, receiving either 50 mg of zinc as zinc acetate or a placebo for six months. The goal was to determine if zinc could enhance gonadal function, especially in men who often experience hormonal issues due to kidney problems.

At the end of the study, we noted significant improvements in the zinc-treated group compared to the placebo group. Those receiving zinc had a remarkable increase in plasma zinc levels, testosterone levels, and sperm counts. Specifically, testosterone levels rose from 2.8 to 5.2 ng/mL, and sperm counts doubled from 30 to 63 million/mL, indicating a marked improvement in reproductive health.

Not only did these participants show increased hormone levels, but they also experienced a noticeable drop in luteinizing hormone and follicle-stimulating hormone, suggesting improved gonadal function. Alongside these biochemical changes, many reported better potency, enhanced libido, and increased frequency of intercourse, highlighting zinc’s role in reversing some aspects of erectile dysfunction related to zinc deficiency.

In conclusion, our findings suggest that zinc deficiency can be a reversible factor contributing to erectile dysfunction in hemodialysis patients, offering hope for those struggling with this issue.

7.5

Vital for health

Most Useful Review

8 people found this helpful

Excellent form of Zinc! It plays a crucial role in combating viral infections, especially helping with erectile dysfunction. It strengthens the immune system, detoxifies the body, and supports male reproductive health. Zinc also promotes healthy hair, nails, and skin, alleviating oily skin and acne in teenagers. A chelated form of Zinc is ideal for bioavailability and rarely causes side effects. Remember to supplement with Copper if taking Zinc long-term!

Frozen Shoulder details

I decided to try zinc as I lack it in my diet. Alongside vitamins and magnesium for my chronic lower back pain, I noticed significant improvement in about three months. I recommend combining it with vitamins B and C to help alleviate stiff shoulders.

Hashimoto details

Zinc's link to Hashimoto's thyroiditis

Rostami R, Beiranvand A, Nourooz-Zadeh S, Rostami M, Mohammadi A, et al. Association Between Essential Trace Elements and Thyroid Antibodies in the Blood of Women with Newly Diagnosed Hashimoto's Thyroiditis. Int J Endocrinol Metab. 2024;22:e145599. doi:10.5812/ijem-145599

We explored the connection between essential trace elements, particularly zinc, and Hashimoto’s thyroiditis (HT) in women who were newly diagnosed. In this study, we looked at a group of 56 women with HT and compared them to 64 matched controls.

The results showed that women with HT had significantly lower levels of selenium, iron, and zinc in their blood compared to the controls. Interestingly, their copper levels were higher. We examined the relationships between these trace elements and thyroid autoantibodies, which can indicate the presence of autoimmune activity affecting the thyroid.

While we noted a significant correlation between lower zinc (and other elements) and higher levels of thyroid antibodies, the study did not specifically focus on zinc treatment. This means that while zinc levels appear to be linked to autoantibody levels in HT, we can't definitively state that zinc treatment will improve the condition without further dedicated research.

Overall, the study indicates that lower zinc levels in conjunction with selenium and iron deficiencies might be involved in the autoimmune response seen in Hashimoto’s thyroiditis. Thus, this provides an avenue for future exploration into zinc's role as a potential supplement for women diagnosed with this condition.

Supports Hashimoto treatment

Most Useful Review

This zinc supplement is effective. It makes me feel better and aids my Hashimoto's condition. I bought it before and would definitely buy it again.

Insomnia details

Cherasse Y, Saito H, Nagata N, Aritake K, Lazarus M, et al. Zinc-containing yeast extract promotes nonrapid eye movement sleep in mice. Mol Nutr Food Res. 2015;59:2087. doi:10.1002/mnfr.201500082

Zinc promotes sleep in mice

We explored the effects of zinc on sleep by looking at how it might help with insomnia. In our study, we gave mice a zinc-containing yeast extract and monitored their behavior and brain activity. The results were quite promising.

We found that administering zinc at doses of 40 and 80 mg/kg led to a significant increase in non-rapid eye movement (NREM) sleep. This means that the mice were not only sleeping longer but also showed less activity, which is a good indicator of effective sleep. Interestingly, we did not observe any changes in rapid eye movement (REM) sleep, a crucial sleep phase for dreaming and deep rest.

Importantly, we didn’t see any negative side effects, such as rebound insomnia, within 24 hours after treating the mice. This suggests that zinc could be a safe option for those struggling with sleep issues, unlike other mineral extracts we tested, such as manganese, iron, and copper, which did not affect locomotor activity at all.

Overall, our findings provide the first evidence that zinc has a direct role in promoting sleep, opening up exciting possibilities for new sleep supplements featuring this essential mineral.

Excellent for insomnia

Most Useful Review

An excellent product that helps eliminate insomnia and promotes deep sleep.

Migraine details

Mazaheri M, Aghdam AM, Heidari M, Zarrin R. Assessing the Effect of Zinc Supplementation on the Frequency of Migraine Attack, Duration, Severity, Lipid Profile and hs-CRP in Adult Women. Clin Nutr Res. 2021;10:127. doi:10.7762/cnr.2021.10.2.127

Zinc reduces migraine symptoms

This study was designed as a randomized double-blind, placebo-controlled trial to examine how zinc gluconate supplementation might alleviate migraine symptoms in adult women. We followed 60 women, averaging about 35 years old, who either received 15 mg of zinc per day or a placebo for a duration of 12 weeks.

Over the trial, we observed significant improvements in those taking zinc. The frequency of migraine attacks, as well as the duration and severity of the headaches, drastically decreased for participants receiving zinc. We used various assessments, such as a numerical rating scale and the Migraine Disability Assessment test, to evaluate these changes.

Additionally, zinc supplementation showed a notable reduction in levels of low-density lipoprotein (LDL) cholesterol and high-sensitivity C-reactive protein (hs-CRP), both of which are associated with inflammation. However, no significant changes in triglycerides or high-density lipoprotein (HDL) levels were seen. After taking initial values into account, the changes in lipid levels and hs-CRP weren’t significant.

Overall, we found that zinc supplementation can beneficially impact migraine symptoms, reducing their severity and frequency among women. This offers a promising direction for migraine management without the side effects often associated with traditional medications.

Migraine-free product

Most Useful Review

No more migraines—this product is wonderful!

Premenstrual Syndrome details

10 people found this helpful

Good value for money! This is my second time ordering zinc. This time I took two boxes at once, as they were on promotion. I really like the chelated form; it's the best for zinc absorption. My husband and I take it together. My PMS has diminished significantly. Previously, I experienced extreme swelling five days before my period. Now, that swelling has vanished and my overall health has greatly improved. Highly recommended!

Acne details

Yee BE, Richards P, Sui JY, Marsch AF. Serum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta-analysis. Dermatol Ther. 2020;33:e14252. doi:10.1111/dth.14252

Based on 16 Researches

Zinc effective for acne treatment

We explored how zinc affects acne through a systematic review and meta-analysis that looked at two main questions. First, we wanted to know if there are differences in zinc levels between people with acne and those without. Second, we examined how effective zinc treatments are for managing acne.

Our findings showed that individuals with acne had noticeably lower serum zinc levels compared to those in the control group. Furthermore, when we looked at treatments, those who received zinc showed a significant reduction in their inflammatory papule count—a common symptom of acne. Importantly, we noted that side effects from zinc supplementation were similar to those seen in other treatments, suggesting that zinc is safe to use.

Overall, acne patients appear to benefit from improved zinc levels, especially when zinc is used either on its own or alongside other acne treatments. This gives hope for those looking for effective ways to tackle acne issues!

Easier acne control

Most Useful Review

230 people found this helpful

With my health issues, I take this zinc consistently, especially in winter. The dosage is right, and I see results! My recent illness was easier, and my skin improved, with fewer acne outbreaks and less peeling. Zinc inhibits viral reproduction and helps with cold symptoms, making recovery faster. Just remember to take it with a 2-hour gap from other supplements.

Cancer details

Buj R, Cole AR, Danielson J, Xu J, Hurd D, et al. cancer cells outcompete macrophages for microenvironmental zinc to drive immunotherapy resistance. bioRxiv. 2025. doi:10.1101/2025.02.08.637227

Zinc's role in cancer immunity

We explored how zinc levels impact cancer cells and immune function, particularly focusing on macrophages, which are crucial for our body’s defense against tumors. Our research revealed that cancer cells often have decreased expression of specific genes tied to immune response, and this links to resistance against therapies designed to unblock immune checkpoints.

By upregulating a zinc importer known as SLC39A9, these cancer cells manage to hoard zinc for themselves, leaving the surrounding tumor microenvironment (TME) depleted of this vital nutrient. This competition for zinc results in macrophages becoming zinc-starved, which diminishes their ability to perform essential tasks like engulfing and destroying cancer cells.

Interestingly, we found that when we replenished zinc levels in the TME—through a dietary intervention—these macrophages could regain their pro-phagocytic function. This change significantly improved the response of certain tumors to immunotherapy treatments. Notably, T cells weren’t required for this transformation, indicating that macrophages alone play a pivotal role.

Our results are clinically relevant, showing that cancer patients with reduced zinc levels in their body tend to experience worse outcomes. Overall, we identified a new mechanism by which cancer cells can disrupt immune function, highlighting zinc’s critical role in both tumor environments and immunotherapy effectiveness.

7.5

Supports cancer treatment

Most Useful Review

Good zinc! For those with zinc deficiency, especially men planning to have children, it's crucial. Zinc acts as an antioxidant that neutralises free radicals, preventing cancer, and stimulates blood production while promoting collagen synthesis for wound healing. The quality is excellent, with a high daily content, and the capsules are conveniently sized.

Cold Sores details

Godfrey HR, Godfrey NJ, Godfrey JC, Riley D. A randomized clinical trial on the treatment of oral herpes with topical zinc oxide/glycine. Altern Ther Health Med. 2001;7:49.

Based on 9 Researches

Zinc cream alleviates cold sores

We conducted a double-blind, placebo-controlled clinical trial to explore the effectiveness of a zinc oxide/glycine cream in treating cold sores caused by facial and circumoral herpes. By dividing 46 participants into two groups, one receiving the zinc treatment and the other a placebo, we aimed to measure how this formulation affected the duration and severity of cold sore symptoms.

Our results were quite promising! Participants who began using the zinc oxide/glycine cream within the first 24 hours of noticing symptoms experienced cold sore lesions that lasted only an average of 5 days, compared to 6.5 days for those on the placebo. Additionally, we noticed a significant reduction in the overall severity of their symptoms, including blistering, soreness, itching, and tingling.

As for side effects, subjects treated with the zinc cream experienced only minor and reversible issues typical of ionic zinc salt solutions. This indicates that the zinc oxide/glycine cream is not only effective but also safe for treating cold sores, presenting a valuable option for many people seeking relief from this common condition.

Effective against skin issues

Most Useful Review

21 people found this helpful

Zinc acts as a powerful antioxidant, vital for immunity and skin health. It helps with cold sores and oily skin by reducing inflammation and sebum production. For colds, I combine zinc with vitamin C and have noticed significant benefits over the years; my children rarely miss school due to illness. It seems to enhance overall resistance during seasonal sickness.

Eczema details

Crisóstomo M, Santos MC, Tavares E, Cunha F. Transient symptomatic zinc deficiency in an exclusively breastfed infant. BMJ Case Rep. 2021;14. doi:10.1136/bcr-2021-241754

Zinc enhances eczema recovery

We investigated the relationship between zinc deficiency and eczema in a 3-month-old infant who was exclusively breastfed. The infant presented with symptoms like scaling erythematous dermatitis affecting her face and other areas, alongside irritability and poor weight gain. Her mother had been taking isoniazid for tuberculosis during pregnancy, which possibly contributed to the infant’s zinc deficiency.

After initial treatments for a suspected skin infection didn’t bring any changes, we found that the baby had low serum zinc levels and low zinc concentration in her breast milk. This led us to believe the skin condition was due to zinc deficiency rather than an infection. We started zinc supplementation, and the infant showed remarkable improvement in her skin condition and weight.

By 6 months, the infant had begun eating solid food, and we stopped the zinc supplements, with no signs of eczema returning. This case underscores the importance of monitoring zinc levels in breastfed infants, especially when mothers are on specific medications that might impact nutrient transfer through breast milk.

Immediate effect

Most Useful Review

It’s very effective! I suffer from eczema and dandruff, and since I started taking zinc, the irritation and itching have disappeared!

Rosacea details

Ahn HJ, Shin MK. Zinc penetration through the skin barrier in atopic dermatitis and rosacea using reflectance confocal microscopy. Exp Dermatol. 2024;33:e14971. doi:10.1111/exd.14971

Zinc penetrates skin in rosacea

We investigated how well zinc penetrates the skin in individuals with rosacea, a common condition that affects skin barrier function. Using a non-invasive technique called reflectance confocal microscopy, we compared the skin barrier permeability between those with rosacea, atopic dermatitis, and healthy individuals.

Our results revealed that zinc penetration was greater in patients with rosacea compared to those with healthy skin. Specifically, we observed higher intensity readings of zinc at a depth of 8 micrometers in the skin of rosacea patients. This indicates that their skin barrier might be more compromised in the upper layers.

Interestingly, when comparing both conditions, we found that patients with atopic dermatitis showed greater zinc penetration at deeper layers of the skin. This suggests subtle differences in how these two conditions affect skin barriers. Overall, the findings suggest that patients with rosacea experience increased permeability in the upper layers of the skin due to weakened barrier function.

Helps inflammation

Most Useful Review

Zinc is excellent! This is my second purchase. I feel it helps with inflammation related to my rosacea and during colds. I take one capsule at night and haven’t noticed any negative effects. I'm pleased with it.

Bacterial Infection details

Prevents complications

Zinc significantly boosts immunity and is beneficial for those suffering skin problems like acne. When I feel unwell, I quickly take a high dose—90 mg of CHELATE zinc along with Vitamin D3, Vitamin K2, Vitamin C, Omega 3, and calcium-magnesium. This regimen effectively resolves my cold symptoms within three days without developing bacterial complications or requiring antibiotics. I highly recommend it, provided you're not allergic!

Ear Infection details

Zinc's mixed impact on ear infections

Based on 8 Researches

Abba K, Gulani A, Sachdev HS. Zinc supplements for preventing otitis media. Cochrane Database Syst Rev. 2010. doi:10.1002/14651858.CD006639.pub2

We explored whether zinc supplements could help prevent otitis media, which is a common ear infection affecting many, especially young children. Our examination included several randomized, placebo-controlled trials where participants received zinc supplements at least once a week for a minimum of a month.

In total, we identified 12 trials, but only 10 provided sufficient data for analysis. Among healthy children from low-income communities, most studies did not show a clear benefit of zinc on reducing ear infections. However, one trial with over 1600 participants did find a significantly lower incidence of otitis media in those taking zinc, suggesting that it might help. Additionally, a small study focusing on infants with severe malnutrition hinted at potential benefits, yet it is important to note this was based on limited data.

Overall, the evidence isn't definitive—while some results point towards positive effects, particularly in specific groups, many trials did not support the effectiveness of zinc in healthy children. Furthermore, zinc supplements appeared safe, with minimal reports of adverse effects.

Boosts immunity

Most Useful Review

1 people found this helpful

We regularly take this easily digestible zinc, especially during the cold season. It significantly boosts immunity by increasing interferon production, essential for combating viral infections. This enhances the function of the thymus gland, improving the body’s ability to recognise and neutralise viruses.

Headache details

Based on 8 Researches

Zinc reduces migraine symptoms

We conducted a randomized, double-blind, placebo-controlled trial to explore how zinc gluconate affects migraine symptoms in women. Sixty participants, with an average age of 35, were given either 15 mg of zinc per day or a placebo for 12 weeks, allowing us to measure the impact on headache frequency, duration, and intensity.

The results were quite promising; zinc supplementation significantly reduced how often headaches occurred, shortened their duration, and decreased the severity of the migraines reported. Participants in the zinc group experienced notable improvements, as indicated by their responses to the headache severity scale and a disability assessment questionnaire.

Furthermore, we found that zinc also had a positive effect on certain health markers. The serum levels of low-density lipoprotein (LDL), total cholesterol, and high-sensitivity C-reactive protein (hs-CRP) decreased with zinc supplementation. However, we didn’t observe significant changes in triglycerides or high-density lipoprotein (HDL) levels after adjusting for baseline values.

In conclusion, zinc supplementation appears to hold beneficial effects on migraine severity and frequency, offering a potential alternative for those who seek relief from these debilitating headaches.

Supports headache relief

Most Useful Review

4 people found this helpful

An excellent chelated form of zinc, well absorbed. I take one capsule daily with food during cold season. Caution: taking it on an empty stomach may cause headaches. It supports immunity and helps with acne due to zinc's anti-inflammatory effects. I take Zinc along with vitamins C and D3 to maintain my family's health. I recommend you stay healthy and happy!

Herpes details

Stops herpes flare-ups

6 people found this helpful

I had a great experience with this zinc, as it caused no side effects and effectively curtailed my monthly herpes outbreaks that lasted over a year and a half. I can confidently attribute my success to zinc, as there was no other treatment administered during this period.

Knee Pain details

1 people found this helpful

This Zinc supplement is effective and does not cause stomach pain, which is a relief for me.

Menopause details

Zinc enhances vitamin D in menopause

Vázquez-Lorente H, Molina-López J, Herrera-Quintana L, Gamarra-Morales Y, López-González B, et al. Effectiveness of eight-week zinc supplementation on vitamin D status and leptin levels in a population of postmenopausal women: a double-blind randomized trial. J Trace Elem Med Biol. 2021;65:126730. doi:10.1016/j.jtemb.2021.126730

We set out to understand how zinc supplementation could affect vitamin D status and leptin levels in postmenopausal women. The study involved 51 healthy postmenopausal women aged between 44 and 76 from Granada, Spain. They were divided into two groups: one receiving a zinc supplement of 50 mg daily for eight weeks and the other receiving a placebo.

Our findings revealed that zinc supplementation significantly improved vitamin D status in these women. Particularly, those who had reached menopause at a younger age saw a notable increase in their vitamin D levels after taking zinc.

Additionally, we discovered a connection between zinc and leptin levels, a hormone that regulates energy balance. Both dietary zinc intake and its plasma levels were found to be inversely related to serum leptin levels—meaning as zinc levels increased, leptin levels tended to decrease.

Overall, these results suggest that zinc supplementation may play a beneficial role during menopause by enhancing vitamin D levels and influencing leptin balance among postmenopausal women.

Family wellness

Most Useful Review

During the pandemic, doctors recommended zinc for its benefits, including supporting skin health and aiding in menopause. It's effective for acne and hair loss, and essential for overall family well-being.

Allergies details

Xu H, Tong K, Iwasaki N, Ohgami N, Tazaki A, et al. Alleviating effect of intranasal zinc on symptoms of allergic rhinitis. J Allergy Clin Immunol Glob. 2025;4:100408. doi:10.1016/j.jacig.2025.100408

Zinc may relieve allergy symptoms

We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.

Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.

The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.

Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.

Boosts immunity

Most Useful Review

30 people found this helpful

Excellent zinc in an easily chelated form! Unlike pharmacy options, I experienced no side effects or allergies. I used to have issues with zinc-containing medications, but this chelate form suits me. I take one capsule daily, and it supports my immunity, hair, skin, thyroid, and reproductive system. No allergy issues this time! I recommend this to everyone. Remember to take copper too, as they can inhibit each other.

Autoimmune Disorder details

Zinc supplementation benefits MS models

Bayiroglu AF, Acar G, Gulbahce-Mutlu E, Baltaci SB, Mogulkoc R, et al. Dietary zinc status is associated with ZnT3 (SLC30A3), IL-6 gene expressions and spinal cord tissue damage in spinal cord tissue in a cuprizone-induced rat Multiple Sclerosis model. J Trace Elem Med Biol. 2024;86:127540. doi:10.1016/j.jtemb.2024.127540

We explored how dietary zinc levels influence spinal cord damage and gene expressions associated with Multiple Sclerosis (MS) using a cuprizone-induced rat model. The study included 46 adult male Wistar rats divided into five groups, with some receiving zinc supplementation while others followed a zinc-deficient diet.

After eight weeks of treatment, we found that the rats with MS symptoms showed elevated markers of tissue damage and inflammation, particularly in the groups that lacked zinc. Notably, those receiving zinc supplementation exhibited significantly reduced levels of harmful substances, bringing them back closer to control levels.

Our findings highlight zinc's protective effects in a model of MS, suggesting that incorporating zinc into treatment plans could help alleviate some symptoms associated with this autoimmune disorder. This is promising for future treatment strategies for those affected by MS.

Strengthened immunity

Most Useful Review

230 people found this helpful

The best zinc! It is 100% digestible, and I noticed the results immediately after taking the first tablet. My hair and eyelashes are stronger now. Zinc is essential for the nervous system, skin, hair, nails, immunity, and eye health. I recommend it to anyone looking to improve their health.

Back Pain details

Bhardwaj A, Swe KMM, Sinha NK. Treatment for osteoporosis in people with beta-thalassaemia. Cochrane Database Syst Rev. 2023;5:CD010429. doi:10.1002/14651858.CD010429.pub3

USERS' SCORE

Good

Based on 3 Reviews

Zinc may boost bone density

We explored how zinc supplementation might help with back pain in individuals with beta-thalassaemia. The research included a randomized controlled trial with 42 participants, where some received zinc while others were given a placebo.

Results showed that zinc supplementation likely increased the bone mineral density (BMD) at the lumbar spine and hip after 12 to 18 months of treatment. This improvement in bone health could suggest potential benefits in pain relief, although the study didn’t directly measure back pain outcomes.

Even though the findings about BMD improvements are promising, we should be cautious. The trial didn't provide direct evidence on whether zinc specifically alleviates back pain. It’s essential to recognize that while we observed positive changes in bone density, interpreting this as a definitive solution for back pain would be premature.

Thus, further research is necessary to connect zinc's effects on bone health to actual pain relief in order to offer clearer guidance on its use as a treatment for back pain.

7.5

Less back pain

Most Useful Review

I purchased zinc as I often suffer from atopy and allergies, taking it periodically. I also started giving it to my husband at the first sign of a cold, which has been less severe and prevented it from extending. We're very pleased as it seems effective for alleviating back pain.

Chronic Cough details

1 people found this helpful

I usually ordered different brands of zinc picolinate, but when they became unavailable, I found this one. I bought five packs as the chelated form is highly digestible and the dosage is excellent. It effectively prevents colds—whenever I feel the onset of sore throat and runny nose, I take two tablets daily for two to three days, and I recover quickly. With Covid, it’s advised to take 50-100 mg daily.

Common Cold details

Zinc shortens cold duration variability

Hemilä H, Chalker E, Tukiainen J. Quantile Treatment Effect of Zinc Lozenges on Common Cold Duration: A Novel Approach to Analyze the Effect of Treatment on Illness Duration. Front Pharmacol. 2022;13:817522. doi:10.3389/fphar.2022.817522

We explored how zinc lozenges affect the duration of the common cold through a detailed analysis of multiple trials. In particular, we focused on the Mossad (1996) trial involving zinc gluconate lozenges, which revealed an average reduction of cold duration by about 4.0 days. While that sounds promising, our findings through a quantile treatment effect (QTE) analysis tell a more nuanced story.

Interestingly, the QTE analysis showed that for individuals suffering from lengthy colds lasting 15 to 17 days, the zinc lozenges could shorten their illness by as much as 8 days. On the flip side, those with shorter, 2-day colds only experienced a 1-day reduction in sickness. This suggests that while zinc may help, its effectiveness varies significantly depending on the initial duration of the cold, making the overall average effect less informative than we might think.

Our examination extended to three trials that used zinc acetate lozenges, yielding a similar average reduction of around 2.7 days. However, again, those averages concealed varying effects for short and long colds, highlighting the importance of looking beyond simple averages in treatment studies.

Overall, we observed that zinc lozenges can indeed help with cold duration, but the extent of that help is very much dependent on how long a person has been suffering. This approach to understanding treatment effects through QTE analysis could have important implications not just for cold treatment but also for analyzing other health outcomes.

Easier cold recovery

Most Useful Review

230 people found this helpful

Given my health issues, particularly primary immunodeficiency and dermatitis, I continually take this supplement, especially through winter. The chelated form works well for me, and I noticed that colds are easier and quicker to recover from, improving my skin condition too.

Constipation details

Zinc may mitigate granisetron constipation

Nacci C, Fanelli M, Potenza MA, Leo V, Montagnani M, et al. Carbon monoxide contributes to the constipating effects of granisetron in rat colon. World J Gastroenterol. 2016;22:9333.

We investigated how zinc might play a role in alleviating the constipation effects caused by granisetron, a medication often used to prevent nausea. In the studies, male rats were treated with varying doses of granisetron, alongside zinc protoporphyrin IX (ZnPPIX), to see how these compounds interacted.

Interestingly, while granisetron was found to increase the time to first defecation in the rats, ZnPPIX alone did not have a notable effect on constipation. However, when combined with granisetron, ZnPPIX successfully reversed the constipation induced by this medication. This suggests that zinc, acting through the heme oxygenase/carbon monoxide (HO/CO) pathway, could potentially mitigate constipation.

Nonetheless, it’s crucial to note that ZnPPIX’s effectiveness was only observed when paired with granisetron; its standalone administration didn’t significantly alter gastrointestinal motility. This highlights a specific interaction rather than a general benefit of zinc in treating constipation.

No constipation noted

Most Useful Review

Great supplement that doesn't cause constipation.

Hypothyroidism details

Zinc's uncertain role in hypothyroidism

Nikkhah M, Vafa M, Abiri B, Golgiri F, Sarbakhsh P, et al. The Effect of Some Micronutrients Multi-Supplementation on Thyroid Function, Metabolic Features and Quality of Life in Patients Treating With Levothyroxine and Vitamin D: A Double-blind, Randomized Controlled Trial. Med J Islam Repub Iran. 2024;38:133. doi:10.47176/mjiri.38.133

We conducted a study to investigate the effects of micronutrient supplementation, including zinc, on thyroid function and overall quality of life in patients with hypothyroidism. Our trial involved 104 participants who were receiving levothyroxine and vitamin D. They were randomly assigned to either a group that received a mix of essential nutrients or a placebo group over eight weeks.

We measured various health markers before and after this period, including thyroid hormone levels, cholesterol, insulin resistance, and blood pressure. Our findings suggested that the group receiving the micronutrient supplement experienced improvements in insulin resistance and overall quality of life. However, it’s important to note that the specific effects of zinc alone are somewhat difficult to isolate, as it was part of a combination of nutrients being tested.

Ultimately, while the study indicates potential benefits of micronutrient supplementation for thyroid function in hypothyroid patients, further trials are necessary to clearly define the role of zinc and other nutrients in this context.

7.5

Improved life quality

Most Useful Review

210 people found this helpful

I have hypothyroidism and a zinc deficiency, resulting in various health issues. I experience hair loss, fatigue, and more. Zinc intake is crucial for thyroid function and hormone regulation. I opt for zinc chelate as its bioavailability is higher. While other medications also contribute to my treatment, zinc has significantly enhanced my quality of life. I also provide it to my family to bolster their immunity.

Prostate Cancer details

Zinc's complex role in prostate cancer

Ghimire K, Awasthi BP, Yadav K, Lee J, Kim H, et al. Prostate cancer-selective anticancer action of an oxindole derivative via HO-1-mediated disruption of metabolic reprogramming. Chem Biol Interact. 2025;408:111393. doi:10.1016/j.cbi.2025.111393

We explored the relationship between zinc levels and prostate cancer treatments, particularly focusing on a novel compound known as 3D. This compound showed a strong potential to target prostate cancer cells, contributing to a decrease in their proliferation rates.

Our analysis revealed that compound 3D selectively impacted key metabolic processes in prostate cancer cells by suppressing factors related to energy production, such as lactate levels. Interestingly, it also reduced the activity of transporters involved in zinc absorption while leaving those responsible for zinc export untouched.

We also found that the effectiveness of 3D could be reversed with zinc treatment, highlighting a complicated interaction between zinc and this therapeutic approach. While the compound successfully lowered zinc levels in cells and inhibited cancer growth, it is essential to note that we did not find significant benefits from zinc treatment by itself in the context of this study.

Overall, our findings suggest that targeting zinc metabolism and enhancing heme oxygenase-1 expression could be a promising strategy in prostate cancer therapy, more so than the direct application of zinc itself. The results illustrate the potential for combining innovative small molecules with an understanding of cancer metabolism in the development of treatment strategies.

Maintains prostate health

Most Useful Review

2 people found this helpful

I take 30 mg of zinc daily for prostate health, recommended by an esteemed doctor in North Carolina. At nearly 67, my PSA level is a low 1.6, which I monitor yearly with my doctor. My research reinforces the importance of zinc in preserving prostate health.

Adhd details

Zinc shows potential for ADHD support

Based on 13 Researches

Talebi S, Miraghajani M, Ghavami A, Mohammadi H. The effect of zinc supplementation in children with attention deficit hyperactivity disorder: A systematic review and dose-response meta‑analysis of randomized clinical trials. Crit Rev Food Sci Nutr. 2022;62:9093. doi:10.1080/10408398.2021.1940833

We explored the impact of zinc supplementation on ADHD symptoms in children through a systematic review and meta-analysis of six randomized clinical trials involving 489 school-aged participants.

While our analysis indicated a notable improvement in overall ADHD symptoms, there were no significant changes in specific areas like hyperactivity and inattention.

The evidence is rated as moderate to very low, highlighting the need for further, more comprehensive research to truly understand zinc's role in managing ADHD symptoms.

7.5

Stabilises mood

Most Useful Review

1 people found this helpful

It enhances resistance and stabilises mood. I take one tablet daily, and my child with ADHD exhibits more stable moods.

Anemia details

Inoue M. Zinc Deficiency Presenting With Diverse Symptoms in a Young Patient: A Case Report. Cureus. 2024;16:e66034. doi:10.7759/cureus.66034

Zinc deficiency linked to anemia

We explored the connection between zinc deficiency and anemia through the case of an 18-year-old woman who faced a series of health issues, including urinary tract infections and insulin dysfunction. After a thorough assessment, she was diagnosed with zinc deficiency, shedding light on how this overlooked issue can impact overall health.

What stood out to us was the rapid recovery the patient experienced after beginning oral zinc supplementation. Zinc plays a critical role in numerous bodily functions, including immune support and protein regulation. By addressing her deficiency, we observed significant improvement in her symptoms, including anemia.

The patient’s diet contained high levels of substances that were inhibiting her zinc absorption, which likely contributed to her condition. This case emphasizes the importance of recognizing zinc deficiency as a potential underlying cause for unexplained health issues, particularly anemia. Prompt diagnosis and treatment can lead to a complete turnaround in the patient's health.

By sharing this experience, we hope to raise awareness among clinicians about the vital role of zinc in managing anemia and encourage timely interventions for patients showing diverse symptoms.

7.5

Boosted immunity

Most Useful Review

47 people found this helpful

Excellent! Zinc is crucial for overall health and necessary for DNA synthesis, wound healing and immune system function. I ensure my multivitamin contains zinc as it aids in treating anemia and helps maintain hormonal balance. Zinc deficiency can lead to various health issues, so I've found it beneficial, especially for older individuals, in strengthening immunity and promoting overall well-being.

Chronic Fatigue Syndrome details

Zinc supplementation may benefit CFS

Maes M, Mihaylova I, De Ruyter M. Lower serum zinc in Chronic Fatigue Syndrome (CFS): relationships to immune dysfunctions and relevance for the oxidative stress status in CFS. J Affect Disord. 2006;90:141.

We explored the relationship between serum zinc levels and chronic fatigue syndrome (CFS) in a study that compared patients with CFS to normal volunteers. By using an atomic absorption method, we measured serum zinc concentrations and found that those suffering from CFS had significantly lower levels of zinc compared to healthy individuals.

Interestingly, we observed a trend indicating that lower zinc levels correlated with greater CFS severity. Patients also reported a negative correlation between their zinc levels and their subjective experiences of infection. This suggests that zinc plays a role in the immune dysfunction commonly seen in CFS.

Furthermore, we noted that lower serum zinc was associated with higher levels of inflammatory markers and certain defects in the early activation of T cells. Since zinc acts as a potent antioxidant, our findings indicate that CFS is linked to increased oxidative stress in these patients. Given this, it may be beneficial for some CFS patients to consider zinc supplements as part of their treatment approach.

7.5

Improved thyroid function

Most Useful Review

210 people found this helpful

I have hypothyroidism and chronic fatigue syndrome due to iron and zinc deficiencies. This affects my health, causing symptoms like hair loss and fatigue. Zinc chelate is crucial for my thyroid function and hormone balance. It has significantly improved my life, and I take it for my family's immunity as well. This brand provides the right dosage, as recommended by my doctor.

Adenoiditis details

21 people found this helpful

Anti-pimple is a powerful antioxidant that preserves the youth and beauty of the skin, hair, and nails, and improves visual acuity. It enhances the body's defences by stimulating the production of antibodies and leukocytes, thus supporting stable immunity. Zinc is vital in treating acne and promotes recovery by reducing skin inflammation and combatting bacterial infections. The typical daily intake for adults is 15 mg, while children need between 3 to 12 mg. Notably, zinc can enhance the body's resistance during colds, making it particularly effective at the first sign of illness. In my experience, my children have not missed any classes due to colds for two years. Moreover, I have not experienced herpes outbreaks in three years.

Cardiovascular Disease details

Guo J, Ma T, Wang B, Xing B, Huang L, et al. Zn protects H9C2 cardiomyocytes by alleviating MAMs-associated apoptosis and calcium signaling dysregulation. Cell Signal. 2025;127:111629. doi:10.1016/j.cellsig.2025.111629

Zinc counters heart cell injury

We set out to investigate how zinc might help protect heart cells from damage caused by a lack of blood flow, known as myocardial ischemia-reperfusion injury (MIRI). Using H9C2 cells, which are derived from rat heart tissue, we simulated this injury by depriving these cells of oxygen and then reintroducing it while treating them with zinc.

Through this process, we found that zinc treatment significantly increased cell viability compared to those that did not receive zinc. Cells exposed to ischemia showed typical signs of trauma, like heightened levels of apoptosis—or programmed cell death—and calcium overload, which can further damage cells.

Interestingly, zinc seemed to tackle these issues by lowering the levels of certain proteins related to cell death. It also played a role in regulating calcium levels by interacting with various cellular pathways. In fact, when we silenced specific proteins involved in these pathways, the protective benefits of zinc were even more pronounced.

Our findings suggest that zinc can relieve the harmful effects of ischemia by mitigating cell death and regulating calcium overload, which offers hope for future treatments for heart-related conditions impacted by blood flow interruptions.

Prostate support

Most Useful Review

1 people found this helpful

I purchased "Zinc Chelate" capsules for my husband to support his cardiovascular system and prostate health. I later took them to help stabilise my blood sugar levels. We are pleased with the results and highly recommend it to older adults as it effectively supports the body, including in tackling cardiovascular disease.

Cold details

Wieland LS. Zinc for prevention and treatment of the common cold: Summary of a Cochrane review. Explore (NY). 2025;21:103111. doi:10.1016/j.explore.2025.103111

Zinc’s effects on colds

We explored how zinc might help in treating and preventing the common cold. The study focused on zinc's effects, isolating it from other treatments to understand its true impact on cold symptoms. By doing this, the researchers aimed to clarify whether zinc could genuinely shorten the duration of a cold or alleviate its symptoms.

The findings were intriguing but showed that zinc might not yield significant benefits for everyone. While some individuals reported a slight reduction in cold symptoms, the evidence did not strongly support zinc as an effective treatment overall.

This means that, for those seeking relief from a nasty cold, zinc alone might not be the go-to solution we hoped it would be. It’s essential to consider this information when deciding on a cold treatment plan and to approach zinc with realistic expectations.

7.5

Eases cold symptoms

Most Useful Review

230 people found this helpful

With numerous health issues such as primary immunodeficiency and dermatitis, I frequently need to use medicine, especially during winter when viruses are rampant. I prefer the chelated form of zinc, which has shown positive effects. The recent illness was milder and without complications, and my skin condition improved as well. Zinc helps make cold symptoms much more bearable and speeds recovery. However, it's vital to note the compatibility of zinc with other supplements. I truly recommend this manufacturer.

Hair Loss details

Matsuoka N, Mizutani T, Kawakami K. Symptom Profile of Patients With Post-COVID-19 Conditions and Influencing Factors for Recovery. J Clin Med Res. 2023;15:116. doi:10.14740/jocmr4855

Based on 9 Researches

Zinc shows promise for hair loss

We explored how zinc acetate hydrate impacts hair loss for patients experiencing symptoms after COVID-19. In our analysis, we looked at 120 symptomatic outpatients over 12 weeks, observing their recovery patterns and any improvements in their symptoms. The focus was on various lingering effects, including fatigue and hair loss, particularly how zinc could potentially alleviate these issues.

Our findings highlighted significant improvements in hair loss for those treated with zinc acetate hydrate at multiple checkpoints (4, 8, and 12 weeks) compared to those who did not receive this treatment. The results were statistically significant and suggested that zinc could be a useful option for those struggling with hair loss post-COVID-19.

Additionally, we noted improvements in fatigue among those receiving zinc, although this was not as pronounced at all time intervals. As a whole, our study emphasized zinc's beneficial effects, particularly for hair loss, providing promising insights for anyone dealing with these challenging post-viral symptoms.

Stopped hair loss

Most Useful Review

24 people found this helpful

A good drug, but the dosage is substantial. I took one capsule daily for 16 days, but experienced constriction in my hands, legs, tingling fingers, and kidney pain. My brother encountered similar symptoms. If discomfort arises, stop immediately. Hair loss ceased, and my hair grew stronger. My brother also noticed enhanced hair growth, and my mother experienced less facial irritation. While I plan to try a lower dosage, I still believe its effect is worthwhile—although I suggest caution for children.

Blood Clot details

M S M, Samal DB, Amirtraj J V, Subramanian S, Venkatasubbu GD. Enhanced coagulation cascade activation and styptic effects of Zn@SiO nanocomposite. Colloids Surf B Biointerfaces. 2024;239:113927. doi:10.1016/j.colsurfb.2024.113927

Zinc enhances blood clot formation

We explored how zinc affects blood clotting, particularly through a substance called Zn@SiO nanocomposite. This material shows promise as a hemostatic agent, which means it helps stop bleeding by promoting the formation of stable blood clots.

During our analysis, we examined various aspects of how this nanocomposite interacts with blood. It activates specific factors in the coagulation cascade—the process our bodies use to form clots. With the presence of zinc in the material, we observed enhanced activation of these factors, leading to improved clot formation.

Our research involved synthesizing and characterizing the Zn@SiO nanocomposite using several methods, including XRD, FTIR, and HRTEM. We also tested its effects on red blood cell aggregation, platelet adhesion, and several vital clotting time measures. The results indicate that Zn@SiO has significant hemostatic properties, showing potential for use in surgeries and trauma care.

This study highlights the exciting role of zinc in optimizing hemostasis, making it a candidate worth considering for medical applications related to bleeding management.

Significant health improvement

Most Useful Review

1 people found this helpful

After taking this supplement for a month, I've seen a notable improvement in my overall health. My immune system has strengthened as I haven't caught a cold or flu since starting it. Additionally, my blood clotting has improved, allowing for quicker healing of minor cuts and wounds. My hair feels thicker, and my skin appears clearer and brighter. It's a great quality product for enhancing overall health!

Bone Pain details

Skin and joint improvement

Excellent! Zinc is great for our cells, supporting prostate function, protein production, wound healing, and maintaining healthy skin. It helps my bone pain and improves the condition of bones and hair.

Chest Pain details

Eby GA, Halcomb WW. High-dose zinc to terminate angina pectoris: a review and hypothesis for action by ICAM inhibition. Med Hypotheses. 2006;66:169.

Zinc treatment for angina pectoris

We delved into an intriguing question: Can high doses of zinc help relieve chest pain caused by angina pectoris? Our research reviewed studies that highlight how zinc may play a role in managing this condition. Angina pectoris often results from arteriosclerosis, where the arteries become narrowed due to cholesterol buildup and other factors.

We discovered that patients with severe atherosclerosis showed promising improvements when treated with high-dose zinc. Specifically, a treatment regimen involved raising serum zinc levels significantly, resulting in symptom relief for many individuals. In one notable case, 12 out of 16 patients experienced measurable benefits, including one patient who also suffered from Raynaud's disease.

Furthermore, our analysis noted that long-term exposure to zinc in the environment correlated with reduced incidence of angina and ischemic events during exercise. Zinc appears to possess antioxidant properties, which may protect against the oxidation of LDL cholesterol, a key player in artery damage. By blocking certain inflammatory factors and promoting better circulation, zinc might enhance heart function and alleviate chest pain.

Based on these findings, we propose that zinc treatment should be considered a fundamental option in both prevention and therapy for atherosclerosis-related chest pain. This could lead to a renewed focus on restoring a healthier cardiac function among those affected by these conditions.

Joint pain relief

Most Useful Review

2 people found this helpful

The quality is excellent. I used it for joint pain, which greatly improved my health. Zinc also boosts immunity and is beneficial during colds and flu. I take one pill daily and recommend it as one package lasts a month.

Heartburn details

Hayashi A, Taki Y, Arai K, Sato S, Higashizono K, et al. Esophageal ulcer related to zinc deficiency following a total gastrectomy. Nutrition. 2023;110:111999. doi:10.1016/j.nut.2023.111999

Zinc's role in heartburn relief

We investigated how zinc affects heartburn through the case of a 76-year-old Japanese man who experienced significant discomfort after undergoing a total gastrectomy. For two weeks, he suffered from a sore throat, heartburn, and difficulty swallowing. Endoscopy revealed deep, craterlike ulcers in his esophagus, but tests for viral infections were negative.

After initial treatment, his symptoms returned, prompting further investigation. Eventually, we found that his serum zinc level was low at 38 µg/dL, which led to a diagnosis of zinc deficiency. Following oral zinc supplementation, the patient reported relief from his symptoms and a noticeable improvement in the esophageal ulcers observed during a follow-up endoscopy.

Over the five years since his treatment, the patient has continued to take zinc supplements and has not faced similar issues again. This case suggests that zinc can play a crucial role in treating heartburn issues related to ulcers, especially in those with a deficiency.

No heartburn experienced

Most Useful Review

2 people found this helpful

This is not my first time ordering this zinc. I appreciate the value for money and its chelated form, which the body absorbs well. It helps with my initial ailments. I had no heartburn when taking it, unlike with another brand. The capsules are a suitable size and easy to swallow. I will continue to order this zinc in future.

Diabetes details

Zinc alleviates diabetic muscle atrophy

Yu X, Chen X, Wu W, Tang H, Su Y, et al. Zinc Alleviates Diabetic Muscle Atrophy via Modulation of the SIRT1/FoxO1 Autophagy Pathway Through GPR39. J Cachexia Sarcopenia Muscle. 2025;16:e13771. doi:10.1002/jcsm.13771

Our investigation aimed to understand how zinc affects muscle atrophy in diabetes, a serious complication that leads to muscle loss. Using diabetes-induced mice, we treated them with zinc sulfate for six weeks and observed notable improvements in their muscle condition.

We conducted various analyses to evaluate the impact of zinc on autophagy—the process that helps manage muscle mass. The results were promising; zinc appeared to enhance muscle recovery by regulating specific molecular pathways connected to muscle health.

Additionally, our in vitro studies with diabetic muscle cells revealed similar results, with zinc supplementation proving beneficial in reducing excessive autophagy. Overall, this suggests that incorporating zinc into treatment plans could be a promising approach to counteract muscle deterioration in diabetic patients.

7.5

Immune system support

Most Useful Review

47 people found this helpful

Zinc is essential for DNA synthesis, wound healing, and hormonal balance. It's crucial for proper immune function and can help prevent colds and other infections. Zinc deficiency can lead to frequent illnesses and has been linked to diabetes. Older adults often suffer from insufficient zinc, which can impact healing and immunity. It’s vital for overall health and well-being.

Indigestion details

Zinc-enhanced therapy improves eradication

Ibrahim N, El Said H, Choukair A. Zinc carnosine-based modified bismuth quadruple therapy standard triple therapy for eradication: A randomized controlled study. World J Clin Cases. 2022;10:227. doi:10.12998/wjcc.v10.i1.227

We explored the effectiveness of a modified bismuth quadruple therapy that includes zinc carnosine, in comparison to the traditional triple therapy for treating indigestion caused by Helicobacter pylori infection. In our study, 92 patients with symptoms of dyspepsia and positive breath tests were randomly assigned to receive either the conventional treatment of esomeprazole, amoxicillin, and clarithromycin for 14 days, or a shorter 10-day course of the new therapy that also included bismuth subcitrate and zinc carnosine.

The results were quite revealing. Our findings showed that the modified bismuth quadruple therapy group had a significantly higher eradication rate of 93.5%, compared to 69.6% in the standard treatment group. This suggests that the addition of zinc carnosine to the treatment regimen could enhance the effectiveness of indigestion relief. Importantly, the side effects reported between the two groups were similar, with only mild dizziness noted in those receiving the new therapy.

Overall, the study indicates that a shorter course of therapy that includes zinc carnosine may be a superior option for individuals suffering from indigestion related to Helicobacter pylori. This approach not only appears to work better but also does not lead to more serious side effects, making it an appealing alternative to traditional treatment methods.

Guaranteed indigestion warning

Most Useful Review

1 people found this helpful

It helps at the first sign of a cold and truly works. I take one tablet three times a day, but only after meals; otherwise, indigestion is guaranteed. I also experience frequent stomach aches.

Flu details

Zinc treatment impacts flu virus entry

In our study, we examined how epipharyngeal abrasive therapy (EAT), which includes the use of zinc chloride, affects the expression of a key molecule known as Cav1.2. This molecule is essential for the influenza virus to enter cells, making it a crucial target in flu prevention strategies.

We compared two groups of patients: those who received EAT and those who did not. Our findings revealed that the levels of Cav1.2 were significantly lower in the EAT group, at a striking 4.19 times less than in the non-treated group. This suggests that the squamous metaplasia induced by EAT—which is a process of changing the epithelium—could be a beneficial approach to limiting flu infections.

The results of the study highlight zinc's potential indirect role in flu prevention by remarking on its contribution to lowering the expression of a critical receptor for the virus. Although we didn't isolate the effects of zinc alone, the findings indicate that treatments involving zinc, like EAT, may offer a straightforward way to help limit the impact of influenza.

Relief from flu

Most Useful Review

5 people found this helpful

Great Zinc! I ordered it in the autumn, and it helps with colds and flu. I use it myself, and my family are very satisfied! It’s definitely a good product with no side effects noticed. If feeling unwell, I recommend increasing the dosage to 3 capsules for 4 to 5 days; it becomes easier immediately!

Nausea details

Asaoka D, Ishihara T, Ezoe S, Hamada I, Kitamura M, et al. Randomized, multicenter, active-controlled open-label study of NPC-25, zinc histidine hydrate, (non-inferiority to NOBELZIN™, zinc acetate dihydrate) for patients with hypozincemia. J Trace Elem Med Biol. 2025;87:127558. doi:10.1016/j.jtemb.2024.127558

Based on 4 Researches

Zinc treatment reduces nausea risk

We conducted a study to evaluate how effective NPC-25, a new form of zinc, is compared to a well-known treatment, NOBELZIN™, for patients with low zinc levels. Participants in this trial had their zinc levels checked and were grouped to receive either NPC-25 or NOBELZIN™.

For a period of up to 24 weeks, we aimed to maintain their zinc levels within a specific target range while closely monitoring for side effects. One of our main goals was to see if NPC-25 could maintain these target zinc levels similarly to NOBELZIN™.

Our findings revealed that NPC-25 was indeed non-inferior to NOBELZIN™, meaning it worked just as well. Importantly, we also observed that those taking NPC-25 reported fewer digestive issues, like nausea and vomiting. This suggests that while both treatments were effective, NPC-25 might be the gentler option.

Nausea prevention advice

Most Useful Review

102 people found this helpful

This zinc only contains the chelated form, which avoids nausea that often occurs with other types. I always take it post-meal to prevent nausea or stomach pain, which can happen on an empty stomach. I have had no adverse effects with this product.

Blurred Vision details

1 people found this helpful

This zinc is potent and easily absorbed in a chelated form. With a dosage of 30 mg, it helps block free radicals and is vital for preserving night vision, as it's found in retinal cells. A deficiency can adversely affect night vision, so I find this supplementation crucial for my health, including immunity and overall well-being.

Food Poisoning details