Doctor's Best Benfotiamine + Alpha-Lipoic Acid

We investigated the potential benefits of alpha-lipoic acid (ALA) for patients with type 2 diabetes mellitus (T2DM) suffering from neuropathy. Over six months, we treated 54 patients with a daily dose of 600 mg of ALA while keeping their current oral medications unchanged. We also included a control group of 24 matched individuals who did not experience neuropathy.

Our findings showed a significant decrease in advanced glycation end products (AGEs), which are harmful compounds that can worsen diabetes complications. The levels of AGEs dropped from 11.89 to 10.95 AU/μg, reflecting the positive impact ALA treatment can have. Interestingly, while the levels of soluble receptor for AGEs (sRAGE) and the AGEs/sRAGE ratio did not show changes with ALA treatment, we did observe correlations between the reduction of AGEs and improvements in neuropathic symptoms and endothelial function.

Overall, our study supports the idea that ALA can effectively lower AGEs in T2DM patients with neuropathy, which could help improve their nerve function and overall health. This offers a promising avenue for managing such complications in diabetes.

9.5

Relief from symptoms

Most Useful Review

This is the best mixture for neuropathy (both diabetic and otherwise). I eventually increased to two a day, which made my urine smell, but it relieved 90% of my neuropathy symptoms in my feet. Be consistent and use sensible care practices to regain your feet. It’s the best and least expensive gift I’ve ever given myself.

Bone Pain details

Working quickly in the warehouse used to leave my feet hurting by the end of the day. However, since I started taking this, I am amazed that the bone pain in my feet has completely vanished. There is, however, a concern about a sweat-like smell compared to other vitamin B supplements.

Diabetes details

SCIENTIFIC SCORE

Possibly Effective

Based on 3 Researches

Alpha-lipoic acid enhances wound healing

Lipoic acid improves wound healing through its immunomodulatory and anti-inflammatory effects in a diabetic mouse model.

Most Relevant Research

We aimed to understand how alpha-lipoic acid (LA) affects wound healing in diabetic conditions. The study involved five groups of mice: healthy controls, wounded healthy mice, wounded diabetic mice, and two groups of wounded diabetic mice treated with different doses of LA for 14 days.

Our findings indicated that LA plays a significant role in improving the healing process. It works by balancing the levels of anti-inflammatory and pro-inflammatory factors that are essential for wound recovery. Specifically, we saw effects on various immune cell types that are vital for healing, indicating that LA may help to enhance recovery in diabetic wounds.

This study highlights the potential of LA as a supportive treatment option for wound healing in diabetic patients, ultimately aiming to reduce the risk of infections and improve overall recovery from injuries.

9.5

Improved memory function

Most Useful Review

As I aged, I noticed my memory declining. Checking my thiamine levels showed they were low, especially on strict diets. Since taking Benfotiamine, I’ve experienced improvements in memory, sleep, and reduced irritability, making it easier to manage my diabetes. I suggest taking this complex as it also protects skin health.

α-Lipoic Acid Ameliorates Arsenic-Induced Lipid Disorders by Promoting Peroxisomal β-Oxidation and Reducing Lipophagy in Chicken Hepatocyte.

Most Relevant Research

We explored the protective effects of alpha-lipoic acid (LA) against liver damage caused by arsenic, a well-known environmental toxin. In our examination, we uncovered the mechanisms through which arsenic harms the liver, including its ability to induce autophagy, apoptosis, and oxidative stress, as well as disrupt lipid metabolism.

Our findings revealed that arsenic negatively impacts liver function primarily by reducing the expression of SIRT1, damaging mitochondria, and impairing a process called peroxisomal β-oxidation. This disruption leads to an increase in lipid accumulation and enhances lipophagy, which is the body's way of breaking down fats. However, when we administered LA, we observed a marked improvement. LA appeared to counteract the damage inflicted by arsenic by boosting SIRT1 levels, improving mitochondrial function, and encouraging peroxisomal β-oxidation.

This study clearly illustrates the potential of alpha-lipoic acid as a protective agent against liver injury due to arsenic exposure. By promoting better lipid metabolism and reducing harmful fat buildup, LA could serve as a valuable option for those affected by liver diseases induced by environmental toxins.

9.5

Cleanses liver effectively

Most Useful Review

This is an incredibly useful and high-quality drug for the entire body. It is the most powerful antioxidant that cleanses and removes metals from the body, which is essential for my family as we reside in a rather polluted city. It cleanses and rejuvenates the liver.