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Supplement Facts
Serving Size: 1 Caplet
Amount Per Serving
%DV
Organic ashwagandha powder (root)(0.2% Withanolides, 0.76 mg)
380 mg
*
Organic ashwagandha extract (root)(0.5% Withanolides, 1.4 mg)
280 mg
*
Organic ashwagandha supercriticalCO2 extract (root) (Withania somnifera) (8% Withanolides, 0.8 mg)
10 mg
*
The product is found useful for the following medical conditions
Anxiety
SCIENTIFIC SCORE
Moderately Effective
Based on 20 Researches
8
USERS' SCORE
Good
Based on 21 Reviews
8.8
8
DHA improves milk and reduces anxiety
DHA Supplementation of Obese Rats throughout Pregnancy and Lactation Modifies Milk Composition and Anxiety Behavior of Offspring.
Most Relevant Research
We explored how supplementing obese mothers with docosahexaenoic acid (DHA) affects milk composition and the anxiety behavior of their offspring. In a study involving female Wistar rats, some were placed on a high-fat diet while others ate regular chow. We supplemented half of the mothers from one month before mating until they weaned their pups with DHA. The goal was to see if this supplementation could improve the quality of their milk and influence the anxiety levels of their babies.
Our findings indicated that the obese mother rats exhibited higher weight and fat levels and their milk contained less beneficial DHA but more corticosterone and leptin. Notably, their offspring showed a higher ratio of omega-6 to omega-3 fatty acids in the milk they consumed, which correlates to increased anxiety levels, especially in female pups. In contrast, those mothers who received DHA supplements had lower body weight and fat and produced milk with higher DHA content. Their offspring not only had a better balance of omega-6 to omega-3 fatty acids but also demonstrated reduced anxiety compared to those from mothers without supplementation.
Overall, this study highlights the significant positive impact of DHA supplementation during pregnancy and lactation in obese rats, as it not only improves the nutritional quality of their milk but also helps decrease anxiety levels in the offspring in a sex-dependent manner.
Our findings indicated that the obese mother rats exhibited higher weight and fat levels and their milk contained less beneficial DHA but more corticosterone and leptin. Notably, their offspring showed a higher ratio of omega-6 to omega-3 fatty acids in the milk they consumed, which correlates to increased anxiety levels, especially in female pups. In contrast, those mothers who received DHA supplements had lower body weight and fat and produced milk with higher DHA content. Their offspring not only had a better balance of omega-6 to omega-3 fatty acids but also demonstrated reduced anxiety compared to those from mothers without supplementation.
Overall, this study highlights the significant positive impact of DHA supplementation during pregnancy and lactation in obese rats, as it not only improves the nutritional quality of their milk but also helps decrease anxiety levels in the offspring in a sex-dependent manner.
9.5
Improved mood
Most Useful Review
Especially at work, where I previously disliked interacting with customers in person, I can personally affirm the effectiveness of this product. Two weeks after adding Ashwagandha to my diet, I've noticed significant enhancements in my mood and energy levels. I battled fatigue from my busy schedule, with long days of work and school, and even caffeine couldn't help. Ashwagandha aids my body in recovering from daily fatigue, keeping me motivated and energised throughout the day, while allowing for relaxation in the evenings. My mood has improved in social settings, which is beneficial since I have social anxiety. I feel uplifted and conversational now; I recommend this product to others in similar situations.
Acne
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.7
USERS' SCORE
Good
Based on 1 Review
8.6
9
Docosahexaenoic acid reduces acne risk
The causal association between polyunsaturated fatty acids and acne: A two-sample Mendelian randomization study.
Most Relevant Research
We investigated the relationship between docosahexaenoic acid (DHA), a type of polyunsaturated fatty acid (PUFA), and the occurrence of acne. Using a method called Mendelian randomization, we looked at how genetic variations associated with DHA might influence acne development in large groups of participants, including over 115,000 individuals from the UK and nearly 364,000 of Finnish ancestry.
Our findings revealed that higher levels of DHA are actually linked to a lower risk of developing acne. Specifically, we found that a significant increase in DHA levels or its proportion compared to total fatty acids corresponded with a reduced likelihood of acne. In contrast, higher levels of linoleic acid (LA), another type of PUFA, were associated with an increased acne risk.
This suggests that balancing our intake of these fatty acids might be important for skin health. Notably, the results pointed towards a genetic connection involving the FADS1 gene, which appears to play a role in how these fatty acids affect our skin.
In conclusion, increasing DHA could be beneficial in protecting against acne, while excessive linoleic acid might have the opposite effect. Overall, our study highlights the importance of these fatty acids in understanding acne risk better.
Our findings revealed that higher levels of DHA are actually linked to a lower risk of developing acne. Specifically, we found that a significant increase in DHA levels or its proportion compared to total fatty acids corresponded with a reduced likelihood of acne. In contrast, higher levels of linoleic acid (LA), another type of PUFA, were associated with an increased acne risk.
This suggests that balancing our intake of these fatty acids might be important for skin health. Notably, the results pointed towards a genetic connection involving the FADS1 gene, which appears to play a role in how these fatty acids affect our skin.
In conclusion, increasing DHA could be beneficial in protecting against acne, while excessive linoleic acid might have the opposite effect. Overall, our study highlights the importance of these fatty acids in understanding acne risk better.
10
Cystic acne improvement
Most Useful Review
Miracle supplement! I'm truly obsessed with this product. Although it sounds like a paid review, I genuinely love it. Since I began taking Ashwagandha daily, I've noticed significant changes — no more cystic hormonal acne, and my cycle has returned to normal. Two big thumbs up!
Arthritis
SCIENTIFIC SCORE
Possibly Effective
Based on 28 Researches
7.3
USERS' SCORE
Good
Based on 1 Review
8.6
9
DHA benefits osteoarthritis treatment
DHA attenuates cartilage degeneration by mediating apoptosis and autophagy in human chondrocytes and rat models of osteoarthritis.
Most Relevant Research
We set out to investigate how docosahexaenoic acid (DHA), a fatty acid known for its health benefits, can affect osteoarthritis (OA), a common degenerative joint disease, particularly among older adults. Using both human chondrocyte models stimulated by IL-1β and rat models created through surgical methods, we aimed to understand DHA's potential to impact chondrocyte behavior and cartilage health.
Our observations revealed that DHA significantly promotes the growth of chondrocytes while reducing cell death, which is a key concern in OA. Notably, we found an increase in autophagosomes—structures that help break down cellular waste—within cells treated with DHA, suggesting enhanced cell health.
In comparing groups, those treated with DHA exhibited healthier cartilage characterized by thickened tissue and a decrease in degeneration when compared to the untreated OA group. We also noted an increase in collagen production, vital for maintaining joint structure. The biochemical analysis indicated that DHA potentially exerts its effects by inhibiting certain pathways associated with cell growth and stress responses, thus enhancing chondrocyte proliferation and survival.
Overall, our findings contribute valuable insights into how DHA can be leveraged as a therapeutic approach for OA, emphasizing its role in protecting and restoring cartilage health.
Our observations revealed that DHA significantly promotes the growth of chondrocytes while reducing cell death, which is a key concern in OA. Notably, we found an increase in autophagosomes—structures that help break down cellular waste—within cells treated with DHA, suggesting enhanced cell health.
In comparing groups, those treated with DHA exhibited healthier cartilage characterized by thickened tissue and a decrease in degeneration when compared to the untreated OA group. We also noted an increase in collagen production, vital for maintaining joint structure. The biochemical analysis indicated that DHA potentially exerts its effects by inhibiting certain pathways associated with cell growth and stress responses, thus enhancing chondrocyte proliferation and survival.
Overall, our findings contribute valuable insights into how DHA can be leveraged as a therapeutic approach for OA, emphasizing its role in protecting and restoring cartilage health.
9.5
Improved mood drastically
Most Useful Review
Amazing purchase! I'm on my third bottle and have noticed a significant change in my mood and joint pain. Due to lupus, I often struggle with fatigue and achy joints, but this has helped tremendously! I'm generally in a better mood and mostly pain-free. I even bought a bottle for my grandmother, who is 76 and suffers from arthritis. She's thrilled with her results!
Bacterial Infection
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Erectile dysfunction resolved
Most Useful Review
After years of believing my erectile dysfunction stemmed from chronic bacterial prostatitis due to an infection, I've found relief with this product. My erectile dysfunction issues are gone for two years now. It has been a game-changer, clarifying that stress was the underlying cause. I recommend this to anyone with similar prostatitis-related issues.
Erectile Dysfunction
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
10
Erectile dysfunction gone
Most Useful Review
Chronic bacterial prostatitis was diagnosed years ago, being told my erectile dysfunction stemmed from a confirmed enterococcus faecalis infection in the prostate, leading to inflammation and a weak immune system. However, since using this product, my erectile dysfunction has disappeared for over two years. It turns out my ED was primarily due to stress affecting my prostate. Although I don’t perceive much stress, this remedy has effectively cured my ED. I highly recommend it for anyone suffering prostatitis potentially triggered by stress. I've tried numerous supplements, but this ashwagandha dosage works perfectly for me—taking it daily keeps my ED at bay, and without it, stress events at work cause it to reoccur.
Cancer
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.9
USERS' SCORE
Good
Based on 1 Review
8.5
9
DHA affects colorectal cancer pathways
Dietary polyunsaturated fatty acids affect PPARγ promoter methylation status and regulate the PPARγ/COX2 pathway in some colorectal cancer cell lines.
Most Relevant Research
We set out to explore how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, affects colorectal cancer (CRC) cells. In this study, we treated five different colorectal cancer cell lines with varying concentrations of DHA, along with other fatty acids like eicosapentaenoic acid (EPA) and linoleic acid (LA). This allowed us to see if DHA could impact the methylation patterns of the PPARγ promoter, a key player in cancer regulation, and affect the relationship between PPARγ and COX2, two important molecules involved in cancer growth.
Our findings revealed that DHA significantly altered the methylation status in some cell lines, effectively demethylating specific regions of the PPARγ promoter. We observed that this demethylation was linked to an increase in the expression of PPARγ in cells where it was hemimethylated. Interestingly, DHA not only boosted PPARγ levels but also downregulated COX2 across all CRC cell lines tested. This suggests that DHA might have a role in reducing inflammatory signals linked to cancer progression.
The overall impact seemed to vary depending on the type of cancer cell we were working with, indicating a cell type-dependent effect of DHA. Notably, we found that DHA was more effective than EPA or LA in modulating the PPARγ promoter. This research shows promising potential for DHA in colorectal cancer treatment and highlights its importance in dietary considerations for cancer management.
Our findings revealed that DHA significantly altered the methylation status in some cell lines, effectively demethylating specific regions of the PPARγ promoter. We observed that this demethylation was linked to an increase in the expression of PPARγ in cells where it was hemimethylated. Interestingly, DHA not only boosted PPARγ levels but also downregulated COX2 across all CRC cell lines tested. This suggests that DHA might have a role in reducing inflammatory signals linked to cancer progression.
The overall impact seemed to vary depending on the type of cancer cell we were working with, indicating a cell type-dependent effect of DHA. Notably, we found that DHA was more effective than EPA or LA in modulating the PPARγ promoter. This research shows promising potential for DHA in colorectal cancer treatment and highlights its importance in dietary considerations for cancer management.
8.8
Mood enhancement
Most Useful Review
I purchased this primarily to support my cancer fight, but it has significantly improved my mood and sleep too. I will certainly continue using it!
Chest Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Reduced chest pain
Most Useful Review
Life changing! This product has proven transformative for me! I get chest pains, and while they can't determine the cause, I tried these and they've helped significantly! I’m unsure whether it's related to anxiety or health, but it has made wonders for me!
Cold
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Mood improvement
Most Useful Review
I was feeling low due to the cold weather. This product lifted my mood considerably, alleviating that blue feeling.
Stroke
SCIENTIFIC SCORE
Moderately Effective
Based on 22 Researches
8.5
USERS' SCORE
Good
Based on 1 Review
8.5
9
DHA shows stroke protection potential
Docosahexaenoic acid protects against ischemic stroke in diabetic mice by inhibiting inflammatory responses and apoptosis.
Most Relevant Research
We aimed to find out whether docosahexaenoic acid (DHA) could offer protection against ischemic stroke in diabetic mice and better understand how it works. In our study, we administered DHA to diabetic mice after they experienced an ischemic stroke and evaluated their recovery over 24 hours and again at three days.
The results were promising; DHA treatment significantly reduced the overall size of brain damage, minimized swelling, and improved neurological function. We observed a notable drop in harmful inflammatory responses. For instance, the number of neutrophils, a type of immune cell that can exacerbate inflammation, decreased in the brain tissue.
Additionally, we noticed that DHA seemed to help the balance between proteins related to cell death. Specifically, it lowered levels of Bax, a pro-apoptotic protein, and increased levels of Bcl-2, which protects cells from death. Our analysis of brain tissue genes indicated that DHA helped regulate inflammatory pathways while boosting beneficial neuroprotective pathways.
The changes weren't limited to the brain either; similar positive shifts occurred in the blood cells, showcasing a systemic benefit. Overall, DHA appears to reduce the damage from stroke by lessening inflammation and cell death in diabetic mice, highlighting its potential as a treatment option for strokes in diabetic individuals.
The results were promising; DHA treatment significantly reduced the overall size of brain damage, minimized swelling, and improved neurological function. We observed a notable drop in harmful inflammatory responses. For instance, the number of neutrophils, a type of immune cell that can exacerbate inflammation, decreased in the brain tissue.
Additionally, we noticed that DHA seemed to help the balance between proteins related to cell death. Specifically, it lowered levels of Bax, a pro-apoptotic protein, and increased levels of Bcl-2, which protects cells from death. Our analysis of brain tissue genes indicated that DHA helped regulate inflammatory pathways while boosting beneficial neuroprotective pathways.
The changes weren't limited to the brain either; similar positive shifts occurred in the blood cells, showcasing a systemic benefit. Overall, DHA appears to reduce the damage from stroke by lessening inflammation and cell death in diabetic mice, highlighting its potential as a treatment option for strokes in diabetic individuals.
8
Mood enhancement
Most Useful Review
I take this supplement each morning following a stroke three weeks ago. It has positively influenced my mood and aids my daily walking routine. Initially, I experienced a sleepless night when taken in the evening, but now I take it in the morning without feeling overstimulated.
Insomnia
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7
USERS' SCORE
Good
Based on 33 Reviews
8
7
Docosahexaenoic acid effects on sleep
The association between plasma metabolites and sleep quality in the Southall and Brent Revisited (SABRE) Study: A cross-sectional analysis.
Most Relevant Research
We explored the relationship between plasma metabolites, including docosahexaenoic acid (DHA), and sleep quality using data from a large cohort study. Our investigation focused on participants' experiences with sleep issues such as difficulty falling asleep and snoring.
Through a meticulous analysis, we found that higher levels of DHA, alongside certain cholesterol types, were linked to lower odds of snoring. However, we didn't uncover a direct connection between DHA and improvements in insomnia, specifically when it came to falling asleep or waking up during the night.
This suggests that while DHA may play a role in sleep quality related to snoring, its impact on insomnia isn't clearly established. Our findings indicate that more nuanced studies would be beneficial in determining the precise effects of DHA on sleep disturbances.
Through a meticulous analysis, we found that higher levels of DHA, alongside certain cholesterol types, were linked to lower odds of snoring. However, we didn't uncover a direct connection between DHA and improvements in insomnia, specifically when it came to falling asleep or waking up during the night.
This suggests that while DHA may play a role in sleep quality related to snoring, its impact on insomnia isn't clearly established. Our findings indicate that more nuanced studies would be beneficial in determining the precise effects of DHA on sleep disturbances.
9.5
Calm sleep
Most Useful Review
This is my third box, and it really helps me sleep calmly and relax. Having struggled with insomnia for years, I'm grateful to my friend for introducing this product. The pills are non-addictive and side-effect free.
