Supplement Facts
Serving Size: 1 Capsule
Serving Per Container: 60
Amount Per Serving
%DV
Coenzyme Q10 (Ubiquinone)
200 mg
†
The product is found useful for the following medical conditions
Migraine details
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.5
USERS' SCORE
Good
Based on 4 Reviews
8.6
9
We conducted a study to see how coenzyme Q10 (CoQ10) supplementation impacts migraine symptoms and inflammation. This randomized double-blind trial involved 45 non-menopausal women with episodic migraines.
Participants took either 400 mg/day of CoQ10 or a placebo for three months, while continuing their usual migraine medications. We observed a significant reduction in migraine frequency, severity, and duration in the CoQ10 group.
Additionally, CoQ10 levels and inflammatory markers showed some changes, specifically a reduction in certain proteins linked to inflammation. However, not all markers responded positively, indicating some limited effectiveness.
Participants took either 400 mg/day of CoQ10 or a placebo for three months, while continuing their usual migraine medications. We observed a significant reduction in migraine frequency, severity, and duration in the CoQ10 group.
Additionally, CoQ10 levels and inflammatory markers showed some changes, specifically a reduction in certain proteins linked to inflammation. However, not all markers responded positively, indicating some limited effectiveness.
10
No pain experienced
Most Useful Review
I took this medication on the recommendation for complex migraines. I've been using it for over a month and have ordered more; I have no pain.
Autoimmune Disorder details
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.6
USERS' SCORE
Good
Based on 2 Reviews
8.5
9.5
We explored the potential benefits of idebenone, a synthetic analog of coenzyme Q10, in treating autoimmune disorders, specifically lupus, in mouse models. By administering idebenone to mice with lupus for eight weeks, we aimed to investigate its impact on disease activity and organ damage.
Our findings showed that idebenone led to a significant reduction in disease severity. Mice that received idebenone exhibited lower mortality rates and improvements in kidney function, indicated by reduced glomerular inflammation and lower levels of certain inflammatory markers. The treatment also minimized the production of proinflammatory cytokines and enhanced mitochondrial metabolism.
Besides benefiting the kidneys, idebenone diminished markers of inflammation throughout the body, which is crucial since lupus often results in systemic damage. Importantly, we noticed that idebenone improved overall metabolism in these mice without causing obvious side effects.
This research supports the idea that modulating mitochondrial function can be a promising therapeutic strategy for managing lupus, opening the door for future studies on its effectiveness in humans.
Our findings showed that idebenone led to a significant reduction in disease severity. Mice that received idebenone exhibited lower mortality rates and improvements in kidney function, indicated by reduced glomerular inflammation and lower levels of certain inflammatory markers. The treatment also minimized the production of proinflammatory cytokines and enhanced mitochondrial metabolism.
Besides benefiting the kidneys, idebenone diminished markers of inflammation throughout the body, which is crucial since lupus often results in systemic damage. Importantly, we noticed that idebenone improved overall metabolism in these mice without causing obvious side effects.
This research supports the idea that modulating mitochondrial function can be a promising therapeutic strategy for managing lupus, opening the door for future studies on its effectiveness in humans.
9
Heart health improvement
Most Useful Review
2 people found this helpful
Effective Kaneka Q10. A generous dose. A really good product with a patented Japanese coenzyme. We rotate between different coenzymes, and this one is exceptional. I will order again. One dose is 200 mg, and I notice a marked improvement in the health of my cardiopathic husband, who constantly takes statins. Cardiopathic patients need this; it's also great for general prevention and beauty, especially amidst the oxidative stress we face.
Cancer details
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.8
USERS' SCORE
Good
Based on 2 Reviews
8.5
9
CoQ10 mitigates chemobrain effects
We explored the potential benefits of Coenzyme Q10 (CoQ10) on cancer patients dealing with a condition commonly referred to as "Chemobrain," which is associated with treatment using the chemotherapy drug cyclophosphamide (CYP). In our study, male rats were given a daily dose of CoQ10 for ten days, while they also received a single dose of CYP to model the effects of chemotherapy on cognition and motor skills.
The findings were promising. CoQ10 not only helped counteract cognitive and motor dysfunctions triggered by CYP but also showed significant neuroprotective effects. Behavioral tests demonstrated improvements, and histopathological analysis confirmed that CoQ10 reduced brain damage linked to oxidative stress caused by CYP. This micronutrient effectively restored levels of the antioxidant enzyme catalase and lowered harmful substances like malondialdehyde.
Furthermore, CoQ10 appeared to inhibit neuronal apoptosis, or cell death, by balancing expressions of key proteins involved in the process. It supported neurogenesis in the hippocampus by increasing important growth factors. Most notably, CoQ10 activated the Wnt/β-catenin signaling pathway, which is crucial for brain health and development.
Overall, our study highlights how CoQ10 may offer a multi-faceted approach to mitigating the adverse effects of chemotherapy on cognitive function, bolstering both brain protection and regeneration.
The findings were promising. CoQ10 not only helped counteract cognitive and motor dysfunctions triggered by CYP but also showed significant neuroprotective effects. Behavioral tests demonstrated improvements, and histopathological analysis confirmed that CoQ10 reduced brain damage linked to oxidative stress caused by CYP. This micronutrient effectively restored levels of the antioxidant enzyme catalase and lowered harmful substances like malondialdehyde.
Furthermore, CoQ10 appeared to inhibit neuronal apoptosis, or cell death, by balancing expressions of key proteins involved in the process. It supported neurogenesis in the hippocampus by increasing important growth factors. Most notably, CoQ10 activated the Wnt/β-catenin signaling pathway, which is crucial for brain health and development.
Overall, our study highlights how CoQ10 may offer a multi-faceted approach to mitigating the adverse effects of chemotherapy on cognitive function, bolstering both brain protection and regeneration.
9
Detox for patients
Most Useful Review
The most vital antioxidant for the heart and circulatory system, it assists in eliminating toxins and waste, thus cleansing every cell in the body. This is particularly beneficial for cancer patients. It serves as our detox❣️
Cardiovascular Disease details
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.3
USERS' SCORE
Good
Based on 8 Reviews
8.5
9
We explored the effects of coenzyme Q10 (CoQ-10) on heart failure (HF) patients by analyzing past literature. Our systematic review examined studies from MEDLINE and the Cochrane Library, focusing on how CoQ-10 influences outcomes like HF-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).
The results from 16 studies showed some promising findings. CoQ-10 was found to significantly lower HF-related mortality by 40%, which is a notable benefit for patients. Additionally, we observed improvements in exercise capacity for those taking CoQ-10. However, when it came to the impact on LVEF, the results were not statistically significant. While there wasn’t a clear-cut improvement in LVEF, we acknowledge that this aspect needs further exploration to fully understand CoQ-10's potential.
In summary, CoQ-10 appears to be effective in reducing mortality rates and enhancing exercise capacity among heart failure patients. Nonetheless, the effect on LVEF is still uncertain and merits additional investigation.
The results from 16 studies showed some promising findings. CoQ-10 was found to significantly lower HF-related mortality by 40%, which is a notable benefit for patients. Additionally, we observed improvements in exercise capacity for those taking CoQ-10. However, when it came to the impact on LVEF, the results were not statistically significant. While there wasn’t a clear-cut improvement in LVEF, we acknowledge that this aspect needs further exploration to fully understand CoQ-10's potential.
In summary, CoQ-10 appears to be effective in reducing mortality rates and enhancing exercise capacity among heart failure patients. Nonetheless, the effect on LVEF is still uncertain and merits additional investigation.
9
Significantly improved health
Most Useful Review
4 people found this helpful
Highly recommended! I gave my mother over 1,200mg/day of CoQ10 for three years, which greatly improved her health. I currently take two capsules daily. If facing serious health issues, I suggest pairing CoQ10 with B vitamins and proteins.
Bone Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.4
9
Pain relief noted
Most Useful Review
Great! After having covid, I developed a complication affecting the pericardium. However, after a course of coenzyme and lipoic (thiocotic) acid, the pain disappeared, and an ultrasound revealed improvements.
Cold Sores details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.4
9
Sore mouth relief
Most Useful Review
When I feel tired, my mouth becomes dry. I recently purchased Zero Coenzyme Q10, both 100mg and 200mg. Whenever I felt fatigued, I used to experience soreness in my mouth, but after taking Coenzyme Q10, that symptom vanished, so I continue to use it.
High Cholesterol details
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.2
USERS' SCORE
Good
Based on 7 Reviews
8.4
9
We delved into the effects of coenzyme Q10 (CoQ10) supplementation on cholesterol levels in adults to determine how it can influence lipid profiles. Through a thorough meta-analysis of fifty randomized controlled trials involving nearly 2800 participants, we explored its potential benefits for reducing cholesterol levels effectively.
Our findings indicated that CoQ10 supplementation significantly lowered levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), while simultaneously increasing high-density lipoprotein cholesterol (HDL-C). This effect was particularly pronounced at a dosage of 400 to 500 mg per day, which was shown to produce the best results in terms of reducing TC.
Overall, the study provided strong evidence that CoQ10 could be a valuable ally in managing high cholesterol, helping to achieve a healthier lipid profile in adults. This research sheds light on a promising dietary supplement that might assist individuals seeking to improve their cholesterol levels effectively.
Our findings indicated that CoQ10 supplementation significantly lowered levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), while simultaneously increasing high-density lipoprotein cholesterol (HDL-C). This effect was particularly pronounced at a dosage of 400 to 500 mg per day, which was shown to produce the best results in terms of reducing TC.
Overall, the study provided strong evidence that CoQ10 could be a valuable ally in managing high cholesterol, helping to achieve a healthier lipid profile in adults. This research sheds light on a promising dietary supplement that might assist individuals seeking to improve their cholesterol levels effectively.
9
Energy boost
Most Useful Review
2 people found this helpful
I purchase Coenzyme CoQ10 for my mother to support her heart and boost her energy. This essential antioxidant, found in high concentrations in the heart and liver, is crucial for ATP (energy) production in cells. Jarrow Formulas Co-Q10 effectively restores Co-Q10 levels diminished or inhibited by statins.
Allergies details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 2 Reviews
8.3
8
We investigated how coenzyme Q10 (Co-Q10) affects allergies, particularly allergic rhinitis and asthma. In our study, we used animal models to mimic these conditions and treated them with Co-Q10, either alone or alongside other compounds like Omega-3 and magnesium sulfate.
We collected and analyzed samples from the lungs, measuring various inflammatory markers such as cytokines and IgE levels, which play critical roles in allergic reactions. The results indicated that Co-Q10 helps promote the activity of a protective protein called Nrf2, which is crucial in defending against allergic responses and inflammation.
By increasing Nrf2 levels, Co-Q10 showed potential in reducing the symptoms associated with allergic conditions, helping to control allergic mediators and inflammatory factors. Overall, we found that Co-Q10 treatment could enhance the body’s resilience to allergens, potentially offering a powerful tool against allergic rhinitis and asthma.
We collected and analyzed samples from the lungs, measuring various inflammatory markers such as cytokines and IgE levels, which play critical roles in allergic reactions. The results indicated that Co-Q10 helps promote the activity of a protective protein called Nrf2, which is crucial in defending against allergic responses and inflammation.
By increasing Nrf2 levels, Co-Q10 showed potential in reducing the symptoms associated with allergic conditions, helping to control allergic mediators and inflammatory factors. Overall, we found that Co-Q10 treatment could enhance the body’s resilience to allergens, potentially offering a powerful tool against allergic rhinitis and asthma.
9
Great for allergies
Most Useful Review
3 people found this helpful
Effective and excellent for those with soy allergies. This is the only form of Co-Q10 that I've discovered that does not contain soy. I am allergic to soy and would feel lost without this product. Thanks, Jarrow!
Chest Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 6 Reviews
8.3
8
Coenzyme Q10 improves angina symptoms
We assessed the effects of coenzyme Q10 on patients suffering from ischemic heart disease, specifically those experiencing stable class II-III angina. In our study, we added coenzyme Q10 at a dosage of 60 mg per day for eight weeks to the standard treatment regimen these patients were already following.
The results showed that this addition significantly improved the clinical status of the patients. Importantly, we did not observe any clinically significant side effects associated with the use of coenzyme Q10. This suggests that it could be a beneficial adjunct therapy for individuals dealing with chest pain related to cardiac issues, enhancing their treatment experience without additional risk.
The results showed that this addition significantly improved the clinical status of the patients. Importantly, we did not observe any clinically significant side effects associated with the use of coenzyme Q10. This suggests that it could be a beneficial adjunct therapy for individuals dealing with chest pain related to cardiac issues, enhancing their treatment experience without additional risk.
9
Chest pain relief
Most Useful Review
Fantastic! Following Covid, I encountered a complication with the pericardium. However, after a course of coenzyme and lipoic (thioctic) acid, the chest pain vanished, and an ultrasound scan later revealed improvements.
Chronic Cough details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.2
7.5
Increased energy levels
Most Useful Review
Recommended by my rheumatologist, this has significantly increased my energy levels despite my fibromyalgia and chronic fatigue. I originally took 200 mg, but I have recently learned that Ubiquinol may be more effectively utilised by the body than Co-Q10, so I intend to switch to that form.
Headache details
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
USERS' SCORE
Good
Based on 4 Reviews
8.2
8
Coenzyme Q10 shows effectiveness against migraines
We investigated the effectiveness of coenzyme Q10 in treating migraines in children, comparing it with the commonly prescribed medication, amitriptyline. Our study involved 72 children, aged 5 to 15, who met the criteria for migraine diagnosis set by the International Headache Society.
Over a three-month period, we observed that coenzyme Q10 had positive therapeutic effects, particularly for those requiring long-term treatment. While amitriptyline provided quicker results, the differences between the two treatments in effectiveness were not significantly noticeable after three months. Both treatments led to improvements in the quality of life for the children involved.
Importantly, we noted that children taking amitriptyline experienced more side effects compared to those receiving coenzyme Q10. This finding positions coenzyme Q10 as a promising option due to its comparable effectiveness and better tolerated adverse effect profile.
Over a three-month period, we observed that coenzyme Q10 had positive therapeutic effects, particularly for those requiring long-term treatment. While amitriptyline provided quicker results, the differences between the two treatments in effectiveness were not significantly noticeable after three months. Both treatments led to improvements in the quality of life for the children involved.
Importantly, we noted that children taking amitriptyline experienced more side effects compared to those receiving coenzyme Q10. This finding positions coenzyme Q10 as a promising option due to its comparable effectiveness and better tolerated adverse effect profile.
9
Effective relief
Most Useful Review
This product is invaluable for my wife's tension headaches. It effectively alleviates her pain if taken immediately at the onset or as a preventative measure when she anticipates a rough day.
Sleep Apnea details
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9.5
USERS' SCORE
Good
Based on 6 Reviews
8.2
9.5
Coenzyme Q10 in sleep apnea study
We explored the impact of various treatments, including coenzyme Q10, on obstructive sleep apnea (OSA) in a patient with adult-onset Leigh disease. This condition often presents with severe neurological symptoms, complicating the patients’ overall health and quality of life.
An overnight sleep study revealed the presence of OSA, which had developed shortly before the neurological symptoms became apparent. Treatment included high doses of thiamine, coenzyme Q, L-carnitine, and vitamins C and E, along with effective management of OSA through continuous positive airway pressure (CPAP).
Following this combined approach, we observed a marked clinical improvement not only in the patient's sleep quality but also in their neurological outcomes. While coenzyme Q10 was part of this combination therapy, its specific contribution to alleviating sleep apnea symptoms cannot be isolated from the other treatments. Overall, the findings suggest that recognizing and treating sleep apnea promptly can enhance patients’ well-being and potentially improve neurological conditions associated with Leigh disease.
An overnight sleep study revealed the presence of OSA, which had developed shortly before the neurological symptoms became apparent. Treatment included high doses of thiamine, coenzyme Q, L-carnitine, and vitamins C and E, along with effective management of OSA through continuous positive airway pressure (CPAP).
Following this combined approach, we observed a marked clinical improvement not only in the patient's sleep quality but also in their neurological outcomes. While coenzyme Q10 was part of this combination therapy, its specific contribution to alleviating sleep apnea symptoms cannot be isolated from the other treatments. Overall, the findings suggest that recognizing and treating sleep apnea promptly can enhance patients’ well-being and potentially improve neurological conditions associated with Leigh disease.
9
Enhanced concentration
Most Useful Review
After taking this vitamin for a month, I feel a surge of energy, and my skin, hair, and nails have improved. Most significantly, I began to sleep better and my concentration has increased. I’m thrilled to have found the perfect solution for my health and well-being. Thanks to the manufacturers for such a high-quality product!
Brain Tumor details
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.6
USERS' SCORE
Good
Based on 6 Reviews
8.1
9
CoQ10 reduces glioblastoma growth
The study focused on understanding how coenzyme Q10 (CoQ) could help manage glioblastoma, a particularly challenging type of brain tumor. We utilized xenograft models with U251 cells implanted in mice to observe tumor growth, inflammation, and vascular changes, alongside assessing the effects of CoQ on various related behaviors, including cell migration and invasion.
We found that CoQ treatment significantly reduced tumor volume in both xenograft and orthotopic models. Interestingly, while it did not directly hinder tumor cell proliferation, it was effective in creating a less hypoxic and vascularized environment. This indicates that CoQ can influence the tumor’s growth dynamics by targeting the underlying conditions that support tumor survival and expansion.
Additionally, CoQ treatment led to a noticeable downregulation of proteins involved in inflammation and angiogenesis, like HIF-1α and NF-kB. This change in molecular activity caused an entire reshaping of the tumor's protein landscape, ultimately impacting how the tumor interacts with its environment. Notably, we observed a restriction in tumor cell migration and invasion, attributed to changes in the cell's structural components.
Overall, our findings suggest that incorporating CoQ into current treatment protocols could provide a holistic approach to combat glioblastoma by simultaneously addressing multiple pathways that facilitate tumor growth and infiltration.
We found that CoQ treatment significantly reduced tumor volume in both xenograft and orthotopic models. Interestingly, while it did not directly hinder tumor cell proliferation, it was effective in creating a less hypoxic and vascularized environment. This indicates that CoQ can influence the tumor’s growth dynamics by targeting the underlying conditions that support tumor survival and expansion.
Additionally, CoQ treatment led to a noticeable downregulation of proteins involved in inflammation and angiogenesis, like HIF-1α and NF-kB. This change in molecular activity caused an entire reshaping of the tumor's protein landscape, ultimately impacting how the tumor interacts with its environment. Notably, we observed a restriction in tumor cell migration and invasion, attributed to changes in the cell's structural components.
Overall, our findings suggest that incorporating CoQ into current treatment protocols could provide a holistic approach to combat glioblastoma by simultaneously addressing multiple pathways that facilitate tumor growth and infiltration.
7.5
Noticed improvements
Most Useful Review
5 people found this helpful
Only positive feedback from me. I take Coenzyme Q10 as part of a course. It’s a superb antioxidant. With age, energy production slows, so a supplement like this is necessary. It supports the brain, cardiovascular system, and heart function, and I’ve noticed an increase in energy and mood. There are clear benefits.
Hypertension details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 4 Reviews
8.1
7
Citicoline and CoQ10 protection study
We investigated how a combination of citicoline and coenzyme Q10 (CoQ10) might impact retinal cell health in a mouse model of ocular hypertension (OHT). Using four groups of mice, including those receiving the combination treatment and a control group, we aimed to understand if these substances could protect against the loss of retinal ganglion cells, which is a major concern in glaucoma.
The treatment was started 15 days prior to inducing ocular hypertension with a laser and continued until we examined the mice about a week later. Our findings were promising: the combination of citicoline and CoQ10 led to a temporary reduction in eye pressure shortly after treatment. Furthermore, it significantly prevented the death of specific retinal cells that are vital for vision.
While we were encouraged by these results, especially regarding cell protection, it's important to note that there were no significant impacts on neurons in the visual pathway areas we studied, like the dLGN. Overall, our research suggests that this combination might offer neuroprotective benefits in specific aspects of ocular hypertension, paving the way for further exploration into treatments that go beyond only lowering eye pressure.
The treatment was started 15 days prior to inducing ocular hypertension with a laser and continued until we examined the mice about a week later. Our findings were promising: the combination of citicoline and CoQ10 led to a temporary reduction in eye pressure shortly after treatment. Furthermore, it significantly prevented the death of specific retinal cells that are vital for vision.
While we were encouraged by these results, especially regarding cell protection, it's important to note that there were no significant impacts on neurons in the visual pathway areas we studied, like the dLGN. Overall, our research suggests that this combination might offer neuroprotective benefits in specific aspects of ocular hypertension, paving the way for further exploration into treatments that go beyond only lowering eye pressure.
7.5
Supports hypertension treatment
Most Useful Review
1 people found this helpful
Best of the Q10 options. This isn't the first time I've ordered for my mother; she requires it regularly for hypertension and cardiovascular issues. Those with varicose veins may also benefit. The effective dosage is 200 mg, taken in the morning after a breakfast that must include fats. Prior to taking, one should consume l-carnitine for better absorption of Q10. For enhanced results, I alternate between Q10 and the PQQ + Q10 regimen. We follow this in courses. It's essential to consult a healthcare practitioner knowledgeable about supplements before use. This review might be helpful; I like it.
Heart Attack details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
USERS' SCORE
Good
Based on 23 Reviews
8
9
We investigated how coenzyme Q10 might help with heart function after a heart attack, particularly focusing on its role in heart remodeling. In a well-structured study involving 55 patients with left ventricular dysfunction following an acute myocardial infarction, we compared the effects of coenzyme Q10 to a placebo over a 24-week period.
Through careful measurements using echocardiography, we observed notable improvements in the walls of the heart and overall heart mass for those taking coenzyme Q10. Specifically, the thickness of the heart walls decreased, and the left ventricular mass was reduced more significantly than in those receiving the placebo.
Additionally, coenzyme Q10 appeared to maintain heart shape and prevent worsening of heart function compared to the placebo group. Our results also highlighted a significant drop in angiotensin-converting enzyme (ACE) levels in the coenzyme Q10 group, suggesting beneficial effects on heart remodeling and function during recovery from a heart attack.
Through careful measurements using echocardiography, we observed notable improvements in the walls of the heart and overall heart mass for those taking coenzyme Q10. Specifically, the thickness of the heart walls decreased, and the left ventricular mass was reduced more significantly than in those receiving the placebo.
Additionally, coenzyme Q10 appeared to maintain heart shape and prevent worsening of heart function compared to the placebo group. Our results also highlighted a significant drop in angiotensin-converting enzyme (ACE) levels in the coenzyme Q10 group, suggesting beneficial effects on heart remodeling and function during recovery from a heart attack.
9
Palpitations ceased
Most Useful Review
15 people found this helpful
Great product! I purchased this for heart concerns as I was experiencing frequent heart palpitations. After I began taking this product, they disappeared.
Liver Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.6
USERS' SCORE
Good
Based on 3 Reviews
8
We conducted a study to explore the effects of high-dose coenzyme Q10 supplementation on patients suffering from liver disease related to metabolic dysfunction, known as Metabolic-dysfunction Associated Steatotic Liver Disease (MASLD). In a well-structured double-blind, placebo-controlled trial with sixty participants, half received 240 mg of coenzyme Q10 daily, while the other half received a placebo for six months.
Our findings were promising. Patients taking coenzyme Q10 showed significant improvements in various aspects of their health related to liver functions and cardiovascular health. Specifically, we observed a reduction in liver fat content, as assessed by the controlled attenuation parameter, along with better blood vessel function and heart performance. For instance, the flow-mediated dilation of the brachial artery and the coronary flow reserve significantly improved in those receiving the supplement.
Interestingly, while the placebo group did not show any improvements during the six-month period, the coenzyme Q10 group demonstrated a clear correlation between the reduction in liver fat and enhancements in micro- and macrovascular functions. These results suggest that coenzyme Q10 could potentially be a beneficial treatment option for those battling MASLD.
Our findings were promising. Patients taking coenzyme Q10 showed significant improvements in various aspects of their health related to liver functions and cardiovascular health. Specifically, we observed a reduction in liver fat content, as assessed by the controlled attenuation parameter, along with better blood vessel function and heart performance. For instance, the flow-mediated dilation of the brachial artery and the coronary flow reserve significantly improved in those receiving the supplement.
Interestingly, while the placebo group did not show any improvements during the six-month period, the coenzyme Q10 group demonstrated a clear correlation between the reduction in liver fat and enhancements in micro- and macrovascular functions. These results suggest that coenzyme Q10 could potentially be a beneficial treatment option for those battling MASLD.
7.5
Benefits liver
Most Useful Review
1 people found this helpful
I take one capsule with a fatty breakfast, which provides noticeable benefits for my liver and heart.
Heart Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
USERS' SCORE
Moderately Good
Based on 37 Reviews
7.9
9
We explored the effectiveness of coenzyme Q10, commonly known as CoQ-10, in treating heart failure (HF) by reviewing multiple studies. Our systematic analysis included research from respected databases like MEDLINE and the Cochrane Library, where we focused on three main outcomes: heart failure-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).
From the 16 studies we examined, we observed that CoQ-10 treatment significantly decreased HF-related mortality by an impressive 40%. Additionally, we noted improvements in exercise capacity among patients, indicating that CoQ-10 could help individuals with heart failure engage in more physical activity and improve their quality of life.
However, when it came to LVEF—the measurement of how well the heart pumps blood—CoQ-10 did not show significant changes. Despite this, we believe that its potential impact on LVEF should be investigated further, as the data does suggest there may be benefits that warrant additional research.
In summary, while CoQ-10 proved to be beneficial in enhancing exercise capacity and reducing mortality associated with heart failure, the exact effects on LVEF remain unclear and would benefit from more focused studies in the future.
From the 16 studies we examined, we observed that CoQ-10 treatment significantly decreased HF-related mortality by an impressive 40%. Additionally, we noted improvements in exercise capacity among patients, indicating that CoQ-10 could help individuals with heart failure engage in more physical activity and improve their quality of life.
However, when it came to LVEF—the measurement of how well the heart pumps blood—CoQ-10 did not show significant changes. Despite this, we believe that its potential impact on LVEF should be investigated further, as the data does suggest there may be benefits that warrant additional research.
In summary, while CoQ-10 proved to be beneficial in enhancing exercise capacity and reducing mortality associated with heart failure, the exact effects on LVEF remain unclear and would benefit from more focused studies in the future.
9
Cardiovascular improvement
Most Useful Review
20 people found this helpful
Good for the heart. This substance has cardioprotective, antiarrhythmic, and hypotensive effects. A large-scale Italian study involving 2664 patients with heart failure showed that long-term use of coenzyme Q10 reduced cyanosis in 78% and edema in 78.6%. Additionally, 63% experienced fewer arrhythmias, and 73% noticed reduced dizziness, with 54% reporting a decrease in multiple symptoms. A 2014 paper from Moscow State University indicated that coenzyme Q10 helped improve left ventricular ejection fraction, increased exercise tolerance, and normalised blood pressure in heart failure patients.
Nausea details
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.5
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.8
9.5
We explored the effects of coenzyme Q10 treatment in a 17-year-old boy with mitochondrial encephalomyopathy, characterized by episodes of muscle weakness and related symptoms such as fatigue, nausea, and vomiting. This patient experienced three episodes over several years, during which his serum creatine kinase levels spiked.
During the intervals between these episodes, the boy showed no muscle weakness and maintained normal levels of creatine kinase. However, increased levels of lactic acid and pyruvic acid were found in his blood following exercise, resulting in acidosis. This situation was further examined through an EEG, muscle biopsy, and mitochondrial enzyme activity analysis which revealed a specific deficiency in cytochrome c oxidase.
After administering a large quantity of coenzyme Q10, we observed a significant improvement. The patient no longer experienced episodes of muscle weakness or nausea, and the atypical increases in lactic acid and pyruvic acid after exercise tests vanished. This suggests that coenzyme Q10 may effectively alleviate certain symptoms tied to mitochondrial dysfunction, particularly nausea.
During the intervals between these episodes, the boy showed no muscle weakness and maintained normal levels of creatine kinase. However, increased levels of lactic acid and pyruvic acid were found in his blood following exercise, resulting in acidosis. This situation was further examined through an EEG, muscle biopsy, and mitochondrial enzyme activity analysis which revealed a specific deficiency in cytochrome c oxidase.
After administering a large quantity of coenzyme Q10, we observed a significant improvement. The patient no longer experienced episodes of muscle weakness or nausea, and the atypical increases in lactic acid and pyruvic acid after exercise tests vanished. This suggests that coenzyme Q10 may effectively alleviate certain symptoms tied to mitochondrial dysfunction, particularly nausea.
7.5
Reduced nausea
Most Useful Review
I am very pleased with the fast delivery and high-quality, convenient packaging. Everything arrived undamaged and the dosage is excellent, with a natural herbal composition. The capsules are a bit large, but I find them easy to swallow, and they have a pleasant citrus taste. I take 1 capsule daily with meals, alongside vitamin D3+K2, magnesium, and vitamin B6. After 10 days of use, I've noticed significant benefits; my headaches have ceased, my energy has increased, and my mood is consistently good. I highly recommend this supplement for anyone engaged in sports or following a diet, as omega-3 revitalises and replenishes essential nutrients.
Irritable Bowel Syndrome details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.7
7.5
Improved bowel function
Most Useful Review
1 people found this helpful
An excellent quality product with well-chosen ingredients. I experienced no allergies or negative reactions. The package is large enough for an extended period, and the capsule size is medium with a neutral taste. It arrived quickly and undamaged. This supplement contains only useful natural ingredients and folic acid. I noticed improvement in bowel function and metabolism after just a week of use, and my nervous system functions better now, making me less anxious. I am confident in the product's effectiveness; just ensure the dosage is appropriate for your age.
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.7
USERS' SCORE
Moderately Good
Based on 7 Reviews
7.6
8
We embarked on a study to investigate the impact of ubiquinol-10—an active form of coenzyme Q10—on patients suffering from chronic fatigue syndrome (CFS). Our research comprised two parts: an open-label study involving 20 patients and a randomized, double-blind, placebo-controlled trial with 43 participants.
In the open-label segment, patients took 150 mg of ubiquinol-10 daily for eight weeks, and both the participants and physicians knew who was receiving the supplement. The results were promising, suggesting improvements in various symptoms of CFS.
Following this, in the randomized trial, participants were assigned to either ubiquinol-10 or a placebo for 12 weeks, with neither the patients nor the doctors aware of who received which treatment. Outcomes showed that those taking ubiquinol-10 experienced significant benefits, reinforcing the notion that this supplement can positively influence CFS symptoms.
Overall, this study suggests that adding ubiquinol-10 to a treatment plan could be a helpful strategy for improving the lives of those dealing with chronic fatigue syndrome.
In the open-label segment, patients took 150 mg of ubiquinol-10 daily for eight weeks, and both the participants and physicians knew who was receiving the supplement. The results were promising, suggesting improvements in various symptoms of CFS.
Following this, in the randomized trial, participants were assigned to either ubiquinol-10 or a placebo for 12 weeks, with neither the patients nor the doctors aware of who received which treatment. Outcomes showed that those taking ubiquinol-10 experienced significant benefits, reinforcing the notion that this supplement can positively influence CFS symptoms.
Overall, this study suggests that adding ubiquinol-10 to a treatment plan could be a helpful strategy for improving the lives of those dealing with chronic fatigue syndrome.
9
Post-COVID recovery
Most Useful Review
1 people found this helpful
If you’re experiencing extreme fatigue after COVID, I highly recommend this CoQ10 supplement. Jarrow provides a high-quality product featuring Kaneka Q10, known for its good bioavailability, which could greatly assist in recovery.
Hypothyroidism details
SCIENTIFIC SCORE
Questionable
Based on 4 Researches
5.5
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.6
4
We evaluated the levels of Coenzyme Q10 (CoQ10) in patients with hypothyroidism and hyperthyroidism to understand its role in thyroid health. The study included participants from both groups, as well as a control group without thyroid issues, ensuring that no subjects had other cardiovascular or metabolic diseases that could interfere with the results.
Our findings showed that hypothyroid patients had a higher average level of CoQ10 in their blood compared to those with hyperthyroidism. Specifically, hypothyroid patients showed levels of 0.97 mcg/ml, while hyperthyroid patients had only 0.51 mcg/ml, with the control group at 0.73 mcg/ml. This suggests that patients with hypothyroidism may have a greater prevalence of higher CoQ10 levels.
However, we found that the differences were not enough to clearly separate those with normal thyroid function from those with either hypothyroidism or hyperthyroidism. While there is a noted inverse relationship between CoQ10 levels and certain thyroid hormones, this indicates that CoQ10 alone may not provide significant benefits for those specifically dealing with hypothyroidism. More research—especially longitudinal studies—is needed to see how treatment and therapy could potentially affect CoQ10 levels and overall thyroid health in these patients.
Our findings showed that hypothyroid patients had a higher average level of CoQ10 in their blood compared to those with hyperthyroidism. Specifically, hypothyroid patients showed levels of 0.97 mcg/ml, while hyperthyroid patients had only 0.51 mcg/ml, with the control group at 0.73 mcg/ml. This suggests that patients with hypothyroidism may have a greater prevalence of higher CoQ10 levels.
However, we found that the differences were not enough to clearly separate those with normal thyroid function from those with either hypothyroidism or hyperthyroidism. While there is a noted inverse relationship between CoQ10 levels and certain thyroid hormones, this indicates that CoQ10 alone may not provide significant benefits for those specifically dealing with hypothyroidism. More research—especially longitudinal studies—is needed to see how treatment and therapy could potentially affect CoQ10 levels and overall thyroid health in these patients.
7.5
Very beneficial supplement
Most Useful Review
2 people found this helpful
This product is excellent and the dosage is convenient. After just a few days of taking it, I began to feel stronger. It has proven to be very helpful alongside my hypothyroidism.
Blood Clot details
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.4
USERS' SCORE
Moderately Good
Based on 8 Reviews
7.5
9
We explored how coenzyme Q10 (CoQ10), a natural compound found in various foods, impacts blood clotting functions. Through a well-structured study, we utilized a randomized, double-blind, placebo-controlled trial with dyslipidemic patients, alongside in vitro tests on human platelets.
Our findings demonstrated that CoQ10 effectively reduces platelet aggregation, granule secretion, platelet spreading, and clot retraction. This means that CoQ10 can help prevent excessive blood clot formation, which is crucial for cardiovascular health.
We observed that CoQ10 works mainly by enhancing a signaling pathway involving cyclic AMP (cAMP) which ultimately diminishes the signaling of integrin αIIbβ3, a key player in platelet function. In addition, the treatment showed promising results in reducing thrombus growth in an animal model, suggesting significant in vivo benefits as well.
This study highlights the potential of CoQ10 supplementation as a protective measure for individuals at risk of cardiovascular diseases by regulating platelet-related processes involved in clotting.
Our findings demonstrated that CoQ10 effectively reduces platelet aggregation, granule secretion, platelet spreading, and clot retraction. This means that CoQ10 can help prevent excessive blood clot formation, which is crucial for cardiovascular health.
We observed that CoQ10 works mainly by enhancing a signaling pathway involving cyclic AMP (cAMP) which ultimately diminishes the signaling of integrin αIIbβ3, a key player in platelet function. In addition, the treatment showed promising results in reducing thrombus growth in an animal model, suggesting significant in vivo benefits as well.
This study highlights the potential of CoQ10 supplementation as a protective measure for individuals at risk of cardiovascular diseases by regulating platelet-related processes involved in clotting.
7.5
Long-term use
Most Useful Review
2 people found this helpful
I've purchased CO-Q10 for the second time and have been taking it for nine years! It has evidently improved my cardiovascular health and mood. I strongly recommend everyone take Q10 for maintaining cardiac blood vessel health and alleviating melancholy.
