Life Extension Optimized Quercetin 250 mg

We explored the effects of quercetin, a natural compound with potential benefits for treating osteoarthritis (OA), specifically focusing on its ability to target damaged chondrocytes, the cartilage cells that play a crucial role in joint health. In our study, we utilized specialized nanoparticles to increase the effectiveness of quercetin, overcoming its usual limitations related to absorption and bioavailability.

Our research involved subjecting human chondrocytes to conditions that mimic OA. Afterward, we treated them with either free quercetin or our quercetin-loaded nanoparticles (Q-NP). We found that the Q-NP not only allowed for better cellular absorption but also selectively induced apoptosis, or programmed cell death, in senescent chondrocytes. This is significant because eliminating these unhealthy cells could pave the way for healthier joint repair and function.

In addition to promoting cell death in the right cells, Q-NP led to an increase in oxidative stress and reduced key markers of cellular aging. We also noted that the treatment halted the cell cycle in cells that needed to be eliminated. Overall, our findings suggest that enhancing quercetin delivery through nanoparticles holds great promise for improving osteoarthritis outcomes by actively removing harmful senescent cells from joint tissues.

9.5

Wonders for shoulders

Most Useful Review

I was sceptical when I first heard about this on talk radio, but it works wonders on my arthritis in my shoulders! I used to take Mobic for that chronic pain.

In-silico exploring pathway and mechanism-based therapeutics for allergic rhinitis: Network pharmacology, molecular docking, ADMET, quantum chemistry and machine learning based QSAR approaches.

Most Relevant Research

We delved into the potential of quercetin as a therapeutic option for treating allergic rhinitis, a common condition affecting roughly 40% of the global population. This study utilized various in-silico approaches, such as network pharmacology and molecular docking, to identify compounds from traditional medicinal plants and assess their effectiveness.

Among the 241 compounds analyzed, quercetin stood out due to its strong binding affinities with important targets linked to inflammatory and immune pathways. Our assessments indicated that quercetin could interact effectively with key cytokines involved in allergic reactions, potentially reducing allergy symptoms.

While the study highlighted promising implications for quercetin, it did not isolate its effects from other examined compounds. Therefore, further experimental testing is needed to affirm its benefits and effectiveness in real-world allergy treatment situations.

8.8

Effective for allergies

Most Useful Review

I recommend quercetin for its benefits in treating allergies and improving blood flow. This natural supplement has anti-inflammatory properties and can alleviate headaches caused by vessel spasms. It has significantly improved my overall well-being.

Common Cold

Prevention recommended

Most Useful Review

For immunity, it is crucial! Following Dr. Murray's advice, I take Quercetin at 250 - 500 mg daily, NAC 600 mg twice a day, and Selenium. This regimen significantly aids in preventing and treating symptoms of colds and viruses. Thank you, Ayherb! Cheers to Dr. Murray!

Asthma

SCIENTIFIC SCORE

Moderately Effective

Based on 10 Researches

Quercetin alleviates asthma symptoms

Quercetin inhibits ferroptosis through the SIRT1/Nrf2/HO-1 signaling pathway and alleviates asthma disease.

Most Relevant Research

We explored how quercetin, a natural compound found in fruits and vegetables, can impact asthma symptoms. Using an ovalbumin-induced mouse model of asthma, we aimed to uncover whether quercetin can help inhibit a process known as ferroptosis, potentially offering a new therapeutic approach for asthma sufferers.

Our findings showed that quercetin effectively reduced inflammation in the asthmatic mice. Specifically, it lowered levels of inflammatory factors such as IL-4, IL-5, and IL-13—substances typically elevated during an asthma attack. Notably, we also observed that quercetin increased the levels of superoxide dismutase, an important antioxidant, while decreasing malondialdehyde and ferric ions that are associated with oxidative stress.

Additionally, quercetin appeared to boost the expression of key proteins involved in defending against oxidative stress, specifically SIRT1, Nrf2, and HO-1. This suggests that quercetin not only helps combat inflammation but may also protect against cellular damage within the lungs. Overall, our study indicates that quercetin holds promise as a beneficial treatment for asthma by addressing both inflammatory and oxidative stress pathways.

8.8

Works for allergies

Most Useful Review

A recommendation for allergies and asthma has proven worthwhile. I haven't needed to use my inhaler while continuing with my Singulair. Consistency in taking these is crucial, and I have it on autoship.

Cancer

SCIENTIFIC SCORE

Moderately Effective

Based on 16 Researches

Quercetin's role against colorectal cancer

Structure-activity relationship analysis of mono-methylated quercetins by comprehensive MS/MS analysis and anti-proliferative efficacy in human colorectal cancer cells.

Most Relevant Research

We aimed to understand how quercetin and its derivatives, especially mono-methylated quercetins (MQs), might help in treating colorectal cancer. Using advanced techniques like tandem mass spectrometry, we identified specific structural features of these flavonoids that could enhance their anti-cancer activities.

Our findings showed that methylation at specific positions on the quercetin molecule significantly improved its ability to fight cancer cells. Notably, 3-O-methylquercetin and 4'-O-methylquercetin were particularly effective. These compounds caused cancer cells to stop dividing and triggered programmed cell death, also known as apoptosis.

We observed that these MQs worked through several mechanisms, such as inducing oxidative stress, disrupting mitochondrial function, and inactivating cancer-related signaling pathways—all while being non-toxic to normal human colon cells. This makes them promising candidates for cancer therapy, especially for patients with colorectal cancer.

Ultimately, our research revealed that small modifications in flavonoid structures could lead to significant improvements in their anti-cancer effectiveness, providing a path for developing targeted treatments for colorectal cancer.

8.8

Allergy management

Most Useful Review

I rely on this product for allergy control without the drowsiness caused by medications. I learned about it from a fellow cancer patient, who has also found it beneficial during their recovery.

Tinnitus

Enhanced sense of smell

Most Useful Review

I can now stop and smell the roses! My husband added a new supplement to my vitamins to help my tinnitus, and it's improved my sense of smell remarkably. I never smelt well and used to think roses were a waste of money. Now, after breathing in the lovely smell of trees post-rain, I have a newfound appreciation. I am also less allergic to my dog! However, I’m now surprised by unpleasant smells too. While it may not work for everyone, it’s worth trying, especially if you have sinus issues.

Dizziness

Ascovertin improves dizziness metrics

[Clinical efficacy of a novel hemorheological drug ascovertin in patients with vascular encephalopathy].

Most Relevant Research

Our exploration focused on the effectiveness of a treatment called ascovertin in patients suffering from stages I and II of vascular encephalopathy, often linked to atherosclerosis. This treatment, comprised of flavonoid dihydroquercetin and ascorbic acid, was administered over a period of 21 days to a group of 21 patients.

In contrast, we had a comparison group of 10 patients who did not receive ascovertin. The results were promising, revealing that those who took ascovertin experienced significant relief from headaches, decreased vertigo, and less overall fatigue. Furthermore, cognitive functions showed noticeable improvement.

Alongside these benefits, we noted a reliable reduction in whole blood viscosity, suggesting better blood flow and health of blood cells. Specifically, ascovertin appeared to enhance cellular rheology, which means our study participants demonstrated improved flexibility of red blood cells, reduced clumping, and lower levels of harmful lipid peroxidation in both their red blood cells and blood plasma.

However, it’s important to mention that because quercetin was part of a combination treatment, isolating its specific effect on dizziness is challenging. Thus, while benefits were observed, the distinct role of quercetin is not definitively determined in this context.

3.8

Worsening dizziness

Most Useful Review

The supplement works, but it made me dizzy, and the sensation increased daily. When I stopped taking it, the dizziness vanished. Although it effectively lowered my blood pressure and may help with blood sugar, the dizziness worsened with continued use. I had hoped it would subside as my body adjusted, but I couldn't take it long enough to find out. If you don’t experience common side effects, I’d say give it a try.