Life Extension CoQ10 200 mg

We examined how a selenium-containing drug, known as RuSe, targets cancer cells while sparing normal cells. This innovative approach leverages the unique properties of selenium, specifically its electrophilic center, to create oxidative stress within cancer cells. By shuttling electrons from biological electron donors, the drug activates a sequence of events detrimental to cancer survival.

The results were striking; we found that the rate of electron transfer at the selenium site is significantly higher in cancer cells compared to normal cells—1.81 times greater, to be precise. This selective action leads to a lethal effect, with the drug being 14.98 times more harmful to cancer cells than to their healthy counterparts. We observed that the generation of superoxide anions from this process causes DNA damage and triggers the p53 signaling pathway, which enhances the drug's effectiveness in killing cancer cells.

Our findings offer an exciting new avenue for crafting chemotherapeutic agents that can be both efficient and less toxic. By exploiting the special properties of selenium, we open the door to more intelligent and targeted cancer therapies that could reduce side effects for patients.

8.8

Defence against cancer

Most Useful Review

Selenium is indispensable for maintaining health, based on its role in protecting against cancer through its antioxidant activity. A daily intake has notably increased my immune response and offers protection against harmful metals.

A Self-Sustaining Antioxidant Strategy for Effective Treatment of Myocardial Infarction.

Most Relevant Research

We examined the role of selenium in treating myocardial infarction (MI), a major cause of death worldwide that can lead to serious heart problems. The study focused on how this antioxidant works across different phases of a heart attack, where harmful reactive oxygen species (ROS) play a significant role in worsening the condition.

Our findings highlighted a new approach using selenium-embedded nanoparticles, which are specially designed to act as antioxidants at various stages of MI. This innovative method allows for selective ROS elimination when it's most needed, leading to impressive recovery outcomes for the heart.

Throughout the research, it became clear that these nanoparticles help protect vital functions in heart cells by reducing cell death, inflammation, and scar tissue, while also encouraging new blood vessel growth. Overall, this self-sustaining antioxidant strategy shows great potential, not just for treating heart attacks but also inspiring therapies for other ischemic conditions.

9.5

Improved energy levels

Most Useful Review

The complex is effective! I began taking it on the advice of a nutritionist to restore my thyroid function, addressing fatigue, muscle weakness, and heart issues. Almost immediately, I felt better; my energy increased, hair loss decreased, and my heartbeat was more stable. I recommend this essential vitamin for optimal body performance. Please like if you find this helpful.

Lung Cancer

The king of anti-cancer must be consumed; I've already had three bottles.

Prostate Cancer

SCIENTIFIC SCORE

Possibly Effective

Based on 16 Researches

Selenium nanoparticles show promise

Intracellular Fate of Sub-Toxic Concentration of Functionalized Selenium Nanoparticles in Aggressive Prostate Cancer Cells.

Most Relevant Research

We explored the impact of selenium nanoparticles, known for their potential anti-cancer properties, on aggressive prostate cancer cells, specifically the PC-3 line. The study focused on understanding how sub-toxic levels of selenium functionalized nanoparticles affect cell proliferation and their intracellular behavior.

By utilizing advanced imaging techniques and careful cryopreparation, we aimed to preserve the integrity of the cancer cells while analyzing the distribution of these nanoparticles within them. Our findings revealed that nanoparticles coated with bovine serum albumin (BSA) reduced the migration capability of the cancer cells more effectively than those coated with chitosan.

This difference may be attributed to the BSA coating's ability to prevent harmful interactions with the cell membranes, which in turn limits the generation of reactive oxygen species that can damage cells. Most intriguingly, we observed that these selenium nanoparticles localized in both the mitochondria and lysosome-related organelles within the cells. The presence of nanoparticles in the mitochondria might explain the significant reduction in the PC-3 cells' ability to proliferate.

Overall, our investigation highlights the promising role selenium nanoparticles can play in cancer treatment strategies, providing valuable insights for further research into their cytotoxic mechanisms against prostate cancer.

9.5

Overall health

Most Useful Review

This excellent supplement prevents cancer, boosts immunity, and improves the circulatory system. Selenium protects against free radicals and is essential for thyroid hormone production.