NOW Supplements Acetyl-L Carnitine

4 people found this helpful

Carnitine, a natural substance similar to B vitamins, corrects metabolic processes and activates fat metabolism. It has various positive effects, supports energy and fat metabolism at the cellular level, enhances endurance and performance, and helps in muscle mass increase. Additionally, it reduces lactic acid in the muscles, lowers cholesterol, and improves liver function.

Menopause details

Reduced menopause symptoms

12 people found this helpful

Acetyl L-Carnitine had a remarkable impact on my menopause symptoms, alleviating my depression, anxiety, and irritability within two weeks. Since then, I feel calm, as though a fog has lifted from my days.

Sciatica details

This is very effective for sciatica, leading to a quick recovery. I highly recommend it for its positive effects.

Back Pain details

12 people found this helpful

Helps with symptoms related to hyperthyroidism. Acetyl L-Carnitine has alleviated my rapid heartbeat and nervousness associated with hyperthyroidism and provided relief for nerve pain in my lower back.

Cardiovascular Disease details

Supports heart health

6 people found this helpful

Acetyl-L-Carnitine plays an essential role in correcting metabolic processes. This substance, found mainly in animal products, bolsters mitochondrial function, our energy producers. It aids in restoring energy levels and may enhance heart muscle function, contributing significantly to well-being and weight loss. I plan to take 500 mg three times daily for several months, which I believe will help in my recovery after physical exertion.

Cold details

Acetyl-L-carnitine's mixed effectiveness

Based on 2 Researches

Bidzinska B, Petraglia F, Angioni S, Genazzani AD, Criscuolo M, et al. Acetyl-L-carnitine effect on pituitary and plasma beta-endorphin responsiveness to different chronic intermittent stressors. J Neuroendocrinol. 1993;5:151.

We examined how acetyl-L-carnitine affects stress responses in rats exposed to cold swimming. Over ten days, we compared the effects of two stress types and found that cold-swimming significantly increased beta-endorphin levels in both the pituitary and plasma. Notably, acetyl-L-carnitine treatment appeared to offset these changes induced by cold stress. However, it’s essential to highlight that while there were improvements observed with acetyl-L-carnitine, the overall effectiveness for treating cold-related symptoms remains uncertain based on these findings.

Prevents illness

Most Useful Review

This medication should be taken at the first sign of a cold or after contact with a sick person. It helps prevent illness, and I would prefer to take it regularly, but it’s rather costly.

Constipation details

Constipation resolved

I was taking normal L-carnitine and felt constipated. However, after switching to this product, my constipation has disappeared! While I don’t notice it much now, it has made a significant difference.

Migraine details

Acetyl-l-carnitine ineffective for migraines

Questionable

Based on 2 Researches

Hagen K, Brenner E, Linde M, Gravdahl GB, Tronvik EA, et al. Acetyl-l-carnitine versus placebo for migraine prophylaxis: A randomized, triple-blind, crossover study. Cephalalgia. 2015;35:987. doi:10.1177/0333102414566817

We conducted a robust study comparing acetyl-l-carnitine to a placebo for preventing migraines.

In a triple-blind, crossover design, 72 participants aged 18-65 received either the treatment or placebo for 12 weeks.

Unfortunately, our findings showed no significant differences in headache days between the two groups, meaning acetyl-l-carnitine did not prove effective as a preventive measure for migraines.

Migraine relief

Most Useful Review

Excellent product; I'm very pleased with my purchase. These capsules are easy to swallow without tasting them. Previously, I used a brand with large, chalky, and odorous pills. While these capsules do have a slight smell, you can take them before noticing it, and they are far less pungent than the last brand. NAC has numerous health benefits (look up NAC and glycine!), but the most significant for me is its apparent elimination of my near migraine-level headaches. Good packaging.

Parkinson details

ALC shows neuroprotective potential

Based on 9 Researches

Afshin-Majd S, Bashiri K, Kiasalari Z, Baluchnejadmojarad T, Sedaghat R, et al. Acetyl-l-carnitine protects dopaminergic nigrostriatal pathway in 6-hydroxydopamine-induced model of Parkinson's disease in the rat. Biomed Pharmacother. 2017;89:1. doi:10.1016/j.biopha.2017.02.007

The study aimed to assess whether acetyl-l-carnitine (ALC) could protect neurons in a rat model of Parkinson's disease.

We found that ALC at 200mg/kg significantly improved motor functions and reduced indicators of neuroinflammation and oxidative stress.

Additionally, it helped preserve important dopaminergic neurons and reduced cell death markers.

Overall, our results suggest ALC could serve as a supplementary treatment for Parkinson's by combating the illness's damaging processes.

7.5

Tremors improved

Most Useful Review

7 people found this helpful

Being a vegetarian, both my mental and physical strength have diminished. However, after eating this product, my physical energy and spirits have noticeably improved, prompting me to consider purchasing it again. Now, the prices are quite reasonable. My father-in-law was recently diagnosed with Parkinson's disease, suffering from constant hand tremors. Previously, he overused his L-rotator muscle, making the symptoms more pronounced. After switching to carnitine, his hand tremors have shown improvement, although he needs to take two pills daily, which he is reluctant to do, fearing it may exacerbate his symptoms.

Polycystic Ovary Syndrome details

Perfect for Polycystic ovary syndrome! I was diagnosed this year and wanted to come off birth controls. These supplements have been great for naturally regulating my periods and reducing my cravings, alongside some other supplements. Excellent product!

Anemia details

Highly recommend this

Absolutely brilliant! This is a robust and effective supplement. L-carnitine, a natural compound associated with B vitamins, is synthesised in the body and is considered a vitamin-like substance. It exists in striated muscle tissues and the liver, playing an important role in metabolic processes that enhance activity. This is an excellent product, and many users have praised it. I have also purchased from this brand, and I look forward to trying it. The capsules are sizeable but manageable. The company offers many superb formulations, and I take these following my struggles with anaemia. I wholeheartedly recommend this supplement!

Anxiety details

Levine J, Kaplan Z, Pettegrew JW, McClure RJ, Gershon S, et al. Effect of intraperitoneal acetyl-L-carnitine (ALCAR) on anxiety-like behaviours in rats. Int J Neuropsychopharmacol. 2005;8:65.

Based on 8 Researches

ALCAR's mixed effects on anxiety

We investigated the effects of acetyl-L-carnitine (ALCAR) on anxiety-like behaviors in rats, using a systematic approach with control groups. Our findings revealed that chronic doses of 50 and 75 mg/kg significantly reduced anxiety, while doses of 10 and 100 mg/kg showed no effect. In an interesting twist, an acute dose of 100 mg/kg led to increased anxiety. This suggests a complex relationship where ALCAR may work differently depending on the dosage and timing. More research is needed to clarify how ALCAR influences anxiety in these cases.

Reduced social fear

Most Useful Review

8 people found this helpful

Six stars out of five! This is the best supplement I've used so far. It significantly reduces stress and improves mood, making it ideal for anyone facing social anxiety or fear of public speaking.

Autoimmune Disorder details

Gharighnia S, Omidi A, Ragerdi Kashani I, Sepand MR, Pour Beiranvand S. Ameliorative effects of acetyl-L-carnitine on corpus callosum and functional recovery in demyelinated mouse model. Int J Neurosci. 2024;134:409. doi:10.1080/00207454.2022.2107515

Based on 10 Researches

ALC improves motor function in MS

We examined the effects of acetyl L-carnitine (ALC) on motor function in mice with a demyelinating condition, simulating aspects of multiple sclerosis. In this study, some mice were treated with ALC while others were not, allowing us to compare their recovery.

The results were promising; ALC not only enhanced balance and motor coordination but also supported myelin repair by lowering oxidative stress. Key genes associated with myelin were positively regulated, indicating ALC's potential as a therapeutic agent in managing autoimmune disorders like MS.

Increased energy for recovery

Most Useful Review

67 people found this helpful

I ordered carnitine for my 85-year-old mother, who had moderate COVID-19 and experienced heart complications and memory issues thereafter. After taking carnitine, her energy and endurance improved significantly, with stable blood pressure and mental clarity returning. We are very pleased with the results.

Blood Clot details

Memory improvement noted

4 people found this helpful

Excellent brain support! I've seen improvements in memory and concentration along with a boost in energy. Most importantly, my daily headaches have disappeared and my blood pressure has normalised. I take one capsule, alongside other supplements, and find the capsules to be the perfect size. The quality of the ingredients is commendable.

Cold Sores details

After yoga, my whole body aches, but after taking this, I feel energised and the soreness is relieved the next day.

Diarrhea details

Acetyl-L-carnitine from another brand caused me diarrhea, but this version did not.

Fibromyalgia details

Relieved muscle cramps

1 people found this helpful

Excellent! As a fibromyalgia sufferer, this product significantly alleviates my muscle cramps.

Heart Disease details

Acetyl-L-carnitine supports heart health

Questionable

Based on 11 Researches

Alanazi WA, Al-Harbi NO, Imam F, Ansari MA, Alhoshani A, et al. Role of carnitine in regulation of blood pressure (MAP/SBP) and gene expression of cardiac hypertrophy markers (α/β-MHC) during insulin-induced hypoglycaemia: Role of oxidative stress. Clin Exp Pharmacol Physiol. 2021;48:478. doi:10.1111/1440-1681.13455

Our study focused on understanding how acetyl-L-carnitine affects heart disease, particularly in conditions of insulin-induced hypoglycemia. We found that when male rats were given acetyl-L-carnitine, it helped maintain normal blood pressure levels, preventing the spikes that occur with hypoglycemia. The supplement also decreased oxidative stress and inhibited markers of heart muscle thickening that usually arise during low blood sugar episodes. Overall, acetyl-L-carnitine appears to support heart health by providing energy and reducing harmful oxidative effects under stress.

Energy boost noted

Most Useful Review

67 people found this helpful

I ordered carnitine for my 85-year-old mother, who had moderate Covid. Post-Covid, she had slight heart complications, fatigue, and memory issues. After taking carnitine, her energy and endurance increased, her blood pressure stabilised, and her memory fog cleared. We're delighted with the results.

High Cholesterol details

Highly recommended supplement

30 people found this helpful

This supplement effectively bolsters brain function and lowers cholesterol levels. I highly recommend you try it.

Hyperthyroidism details

Blood test improvement

2 people found this helpful

Helps to balance hyperthyroidism. Excellent for individuals with hyperthyroidism; it aids in balancing it when used alongside prescription drugs. I have been using it for a month, and there has been a noticeable change in my blood tests.

Alzheimer details

27 people found this helpful

A great supplement with many benefits. I initially purchased Acetyl-L-Carnitine for my 94-year-old mother, who has dementia, due to its antioxidant properties and enhancement of cognitive abilities, as well as its capacity to increase glutathione essential for brain function. It also improves blood flow, beneficial for people with dementia, Alzheimer's, and Parkinson's. I have also started using it for reducing oxidative stress and increasing energy.

Blurred Vision details

Clearer vision achieved

The biggest benefit of using Acetyl-L-Carnitine is that my vision is clearer, and I can focus faster since starting this supplement.

Chronic Fatigue Syndrome details

Malaguarnera M, Gargante MP, Cristaldi E, Colonna V, Messano M, et al. Acetyl L-carnitine (ALC) treatment in elderly patients with fatigue. Arch Gerontol Geriatr. 2008;46:181.

Based on 4 Researches

ALC reduces fatigue in elderly

We investigated the impacts of acetyl L-carnitine (ALC) on chronic fatigue in elderly patients, examining 96 individuals aged 70 and above. The study utilized fatigue scales to assess changes after treatment.

Results indicated that ALC significantly reduced both physical and mental fatigue while improving cognitive function and overall physical status. Participants reported a notable decrease in muscle pain and sleep disorders, alongside improvements in fatigue severity.

Overall, ALC shows promise as a treatment option for alleviating chronic fatigue in older adults.

Significant improvement.

Most Useful Review

81 people found this helpful

I suspect I have CFS, and this product improved my condition remarkably within a day. I reduced my sleep requirement from 9.5 hours to about 8.5 hours and felt more energetic with fewer headaches. Discovering that I had symptoms of CFS was surprising; I always thought I had depression, but anti-depressants weren't effective. This treatment has been a miracle for me. If you're persistently tired, give it a go—you have nothing to lose but a bit of money.

Common Cold details

Reduces cold sensitivity

Although I'm on a relaxed diet, I felt stagnant until I realised this product was making a difference! I've become less sensitive to the cold compared to before, which was quite pleasant.

Obesity details

Vital for energy production

10 people found this helpful

L-carnitine is an essential nutrient for fat burning. In its absence, one may experience fatigue, obesity, elevated blood lipids, and aging. Naturally occurring, it carries fatty acids to the mitochondria. Without sufficient levels, fatty acids accumulate as body fat, which can lead to obesity and related fatigue and muscle weakness. As such, L-carnitine is crucial for people today.

Bone Pain details

15 people found this helpful

Nurse Approved! ✴️ I used to experience nerve pain radiating from my buttocks to my lower back. After taking this daily, I'm now 💯% pain-free! I previously tried gabapentin but disliked the side effects. As a nurse, I spend over 10 hours on my feet 3-4 days a week, and I haven’t felt any pain regardless of my activity levels. A truly life-changing supplement!

Pelvic Pain details

Pain-free transformation

15 people found this helpful

Nurse Approved! ✴️I used to have nerve pain that radiated from my back to my legs. I began taking it daily and now I am 💯% pain free! Having tried gabapentin and disliked the side effects, I can confidently say this is a true life-changing supplement. I work as a nurse, spending over 10 hours on my feet 3-4 days a week, yet I haven't experienced any pain regardless of the demands on my body.

Adenoiditis details

I found this product excellent and am very pleased with my purchase. The capsules are easy to swallow without any taste. Previously, I used a brand with large, chalky pills that smelled terrible. Although these capsules have a slight odour, they're much more bearable and go down quickly. NAC is noted for numerous health benefits (you might like to research NAC and glycine!), but for me, the most significant advantage has been the near elimination of my previously almost migraine-level headaches. The packaging is also quite good.

Heart Attack details

Acetyl-L-carnitine benefits heart function

Gasparetto A, Corbucci GG, De Blasi RA, Antonelli M, Bagiella E, et al. Influence of acetyl-L-carnitine infusion on haemodynamic parameters and survival of circulatory-shock patients. Int J Clin Pharmacol Res. 1991;11:83.

We examined the effects of acetyl-L-carnitine infusion on patients experiencing circulatory shock, focusing on those with heart conditions. In a double-blind study involving 115 patients across ten intensive care units, we found that this treatment improved blood oxygenation and reduced heart rate and right atrial pressure in cardiogenic shock patients.

Our results also indicated increases in systolic and mean arterial pressures for patients in septic shock. This suggests that acetyl-L-carnitine could complement standard treatments in managing hypoxic conditions related to heart issues.

Great for workouts

Most Useful Review

10 people found this helpful

This Acetyl-L-Carnitine is excellent, albeit pricey. I typically take 6 capsules before workouts or 3 in the morning for heart support. It significantly enhances my ability to run and perform intense cardio without fatigue.

Sleep Apnea details

Product efficiency assured

3 people found this helpful

This is a good product; its quality is worth the money. Fat burning during workouts is slightly quicker, and recovery along with excellent sleep is guaranteed. I could provide a more detailed review, but it’s simpler to try it and see the results for yourself. Wishing you good health!

Tinnitus details

Acetyl-L-Carnitine shows potential

Gopal KV, Thomas BP, Mao D, Lu H. Efficacy of carnitine in treatment of tinnitus: evidence from audiological and MRI measures-a case study. J Am Acad Audiol. 2015;26:311. doi:10.3766/jaaa.26.3.10

We aimed to explore if acetyl-L-carnitine (ALCAR) could alleviate tinnitus symptoms and whether improvements would reflect in audiological and MRI assessments.

In a case study involving a 41-year-old woman with hearing loss and tinnitus, we tracked changes before and after 30 days of ALCAR supplementation at 1,000 mg daily.

The results showed promising changes in both objective measures and her personal experience, suggesting ALCAR could be a beneficial treatment option for tinnitus.

7.5

Improved cognitive functions

Most Useful Review

21 people found this helpful

The effect I noted was an improvement in memory and attention. My eyesight became brighter, hearing improved, and tinnitus decreased. This dietary supplement is also used for depression. I felt uplifted, though not consistently. At times, life felt vibrant and colourful, which was an unexpected bonus, affirming the efficacy of this supplement. However, L-carnitine took about 3-4 weeks to work.

Mild Cognitive Impairment details

Neuroprotective Effects

Clinical studies advocate Acetyl-L-Carnitine for treating asthma, vascular dementia, mild cognitive decline, and depressive disorders in the elderly as part of comprehensive therapy.

Heartburn details

No heartburn experienced