NOW Supplements Acetyl-L Carnitine

1 people found this helpful

Liver Disease details

Excellent quality, benefit for the liver, perfect size.

Vital for energy production

Obesity details

10 people found this helpful

L-carnitine is an essential nutrient for fat burning. In its absence, one may experience fatigue, obesity, elevated blood lipids, and aging. Naturally occurring, it carries fatty acids to the mitochondria. Without sufficient levels, fatty acids accumulate as body fat, which can lead to obesity and related fatigue and muscle weakness. As such, L-carnitine is crucial for people today.

This is very effective for sciatica, leading to a quick recovery. I highly recommend it for its positive effects.

Sciatica details

After yoga, my whole body aches, but after taking this, I feel energised and the soreness is relieved the next day.

Cold Sores details

Acetyl-L-carnitine benefits heart function

Heart Attack details

Gasparetto A, Corbucci GG, De Blasi RA, Antonelli M, Bagiella E, et al. Influence of acetyl-L-carnitine infusion on haemodynamic parameters and survival of circulatory-shock patients. Int J Clin Pharmacol Res. 1991;11:83.

We examined the effects of acetyl-L-carnitine infusion on patients experiencing circulatory shock, focusing on those with heart conditions. In a double-blind study involving 115 patients across ten intensive care units, we found that this treatment improved blood oxygenation and reduced heart rate and right atrial pressure in cardiogenic shock patients.

Our results also indicated increases in systolic and mean arterial pressures for patients in septic shock. This suggests that acetyl-L-carnitine could complement standard treatments in managing hypoxic conditions related to heart issues.

7.5

Essential for heart

Most Useful Review

L-carnitine is crucial for allowing fatty acids to penetrate cell membranes. It is advisable to take it while losing weight, especially before cardio, as this aids lipolysis, helping transport fatty acids into the mitochondria for oxidation! I consume 4 capsules 30 minutes prior to cardio sessions. It’s also beneficial to take L-carnitine daily for our main muscle—our heart. 1-2 capsules a day is effective. This supplement truly works; just use it correctly!

Updated: Mar 2026

Parkinson details

ALC shows neuroprotective potential

Based on 9 Researches

Afshin-Majd S, Bashiri K, Kiasalari Z, Baluchnejadmojarad T, Sedaghat R, et al. Acetyl-l-carnitine protects dopaminergic nigrostriatal pathway in 6-hydroxydopamine-induced model of Parkinson's disease in the rat. Biomed Pharmacother. 2017;89:1. doi:10.1016/j.biopha.2017.02.007

The study aimed to assess whether acetyl-l-carnitine (ALC) could protect neurons in a rat model of Parkinson's disease.

We found that ALC at 200mg/kg significantly improved motor functions and reduced indicators of neuroinflammation and oxidative stress.

Additionally, it helped preserve important dopaminergic neurons and reduced cell death markers.

Overall, our results suggest ALC could serve as a supplementary treatment for Parkinson's by combating the illness's damaging processes.

Tremors improved

Most Useful Review

7 people found this helpful

Being a vegetarian, both my mental and physical strength have diminished. However, after eating this product, my physical energy and spirits have noticeably improved, prompting me to consider purchasing it again. Now, the prices are quite reasonable. My father-in-law was recently diagnosed with Parkinson's disease, suffering from constant hand tremors. Previously, he overused his L-rotator muscle, making the symptoms more pronounced. After switching to carnitine, his hand tremors have shown improvement, although he needs to take two pills daily, which he is reluctant to do, fearing it may exacerbate his symptoms.

Updated: Mar 2026

Back Pain details

12 people found this helpful

Helps with symptoms related to hyperthyroidism. Acetyl L-Carnitine has alleviated my rapid heartbeat and nervousness associated with hyperthyroidism and provided relief for nerve pain in my lower back.

Blurred Vision details

Clearer vision achieved

The biggest benefit of using Acetyl-L-Carnitine is that my vision is clearer, and I can focus faster since starting this supplement.

Menopause details

Increased body warmth

1 people found this helpful

Since starting this, I've noticed my body warms up and I sweat more, which helps with calorie burning. Even in menopause, I've felt less sluggish and wish to continue using it.

Perfect for Polycystic ovary syndrome! I was diagnosed this year and wanted to come off birth controls. These supplements have been great for naturally regulating my periods and reducing my cravings, alongside some other supplements. Excellent product!

Polycystic Ovary Syndrome details

27 people found this helpful

Alzheimer details

A great supplement with many benefits. I initially purchased Acetyl-L-Carnitine for my 94-year-old mother, who has dementia, due to its antioxidant properties and enhancement of cognitive abilities, as well as its capacity to increase glutathione essential for brain function. It also improves blood flow, beneficial for people with dementia, Alzheimer's, and Parkinson's. I have also started using it for reducing oxidative stress and increasing energy.

Anemia details

Highly recommend this

Absolutely brilliant! This is a robust and effective supplement. L-carnitine, a natural compound associated with B vitamins, is synthesised in the body and is considered a vitamin-like substance. It exists in striated muscle tissues and the liver, playing an important role in metabolic processes that enhance activity. This is an excellent product, and many users have praised it. I have also purchased from this brand, and I look forward to trying it. The capsules are sizeable but manageable. The company offers many superb formulations, and I take these following my struggles with anaemia. I wholeheartedly recommend this supplement!

Anxiety details

ALCAR's mixed effects on anxiety

Based on 8 Researches

Levine J, Kaplan Z, Pettegrew JW, McClure RJ, Gershon S, et al. Effect of intraperitoneal acetyl-L-carnitine (ALCAR) on anxiety-like behaviours in rats. Int J Neuropsychopharmacol. 2005;8:65.

We investigated the effects of acetyl-L-carnitine (ALCAR) on anxiety-like behaviors in rats, using a systematic approach with control groups. Our findings revealed that chronic doses of 50 and 75 mg/kg significantly reduced anxiety, while doses of 10 and 100 mg/kg showed no effect. In an interesting twist, an acute dose of 100 mg/kg led to increased anxiety. This suggests a complex relationship where ALCAR may work differently depending on the dosage and timing. More research is needed to clarify how ALCAR influences anxiety in these cases.

Reduced social fear

Most Useful Review

8 people found this helpful

Six stars out of five! This is the best supplement I've used so far. It significantly reduces stress and improves mood, making it ideal for anyone facing social anxiety or fear of public speaking.

Updated: Mar 2026

Brain Tumor details

Effective recovery aid

94 people found this helpful

It improves brain function. I used it for recovery during long subway rides when I would feel dizzy, resembling a state of recharge. After taking one capsule daily for a month, those symptoms ceased, and my memory and performance improved significantly. Please rate my answer if it was helpful!

Acetyl-L-carnitine from another brand caused me diarrhea, but this version did not.

Diarrhea details

Fibromyalgia details

Relieved muscle cramps

1 people found this helpful

Excellent! As a fibromyalgia sufferer, this product significantly alleviates my muscle cramps.

Heart Disease details

Acetyl-L-carnitine supports heart health

Questionable

Based on 11 Researches

Alanazi WA, Al-Harbi NO, Imam F, Ansari MA, Alhoshani A, et al. Role of carnitine in regulation of blood pressure (MAP/SBP) and gene expression of cardiac hypertrophy markers (α/β-MHC) during insulin-induced hypoglycaemia: Role of oxidative stress. Clin Exp Pharmacol Physiol. 2021;48:478. doi:10.1111/1440-1681.13455

Our study focused on understanding how acetyl-L-carnitine affects heart disease, particularly in conditions of insulin-induced hypoglycemia. We found that when male rats were given acetyl-L-carnitine, it helped maintain normal blood pressure levels, preventing the spikes that occur with hypoglycemia. The supplement also decreased oxidative stress and inhibited markers of heart muscle thickening that usually arise during low blood sugar episodes. Overall, acetyl-L-carnitine appears to support heart health by providing energy and reducing harmful oxidative effects under stress.

Energy boost noted

Most Useful Review

67 people found this helpful

I ordered carnitine for my 85-year-old mother, who had moderate Covid. Post-Covid, she had slight heart complications, fatigue, and memory issues. After taking carnitine, her energy and endurance increased, her blood pressure stabilised, and her memory fog cleared. We're delighted with the results.

Updated: Mar 2026

Hyperthyroidism details

Blood test improvement

2 people found this helpful

Helps to balance hyperthyroidism. Excellent for individuals with hyperthyroidism; it aids in balancing it when used alongside prescription drugs. I have been using it for a month, and there has been a noticeable change in my blood tests.

Migraine details

Acetyl-l-carnitine ineffective for migraines

Questionable

Based on 2 Researches

USERS' SCORE

Good

Based on 2 Reviews

Hagen K, Brenner E, Linde M, Gravdahl GB, Tronvik EA, et al. Acetyl-l-carnitine versus placebo for migraine prophylaxis: A randomized, triple-blind, crossover study. Cephalalgia. 2015;35:987. doi:10.1177/0333102414566817

We conducted a robust study comparing acetyl-l-carnitine to a placebo for preventing migraines.

In a triple-blind, crossover design, 72 participants aged 18-65 received either the treatment or placebo for 12 weeks.

Unfortunately, our findings showed no significant differences in headache days between the two groups, meaning acetyl-l-carnitine did not prove effective as a preventive measure for migraines.

7.5

Notable improvements

Most Useful Review

3 people found this helpful

We frequently host the entire family. Acetyl-L-Carnitine is the best form for absorption. A teenager with disabilities and migraines takes this supplement along with a basic protocol, and the improvements are noticeable over the year.

Updated: Mar 2026

Autoimmune Disorder details

ALC improves motor function in MS

Based on 10 Researches

Gharighnia S, Omidi A, Ragerdi Kashani I, Sepand MR, Pour Beiranvand S. Ameliorative effects of acetyl-L-carnitine on corpus callosum and functional recovery in demyelinated mouse model. Int J Neurosci. 2024;134:409. doi:10.1080/00207454.2022.2107515

We examined the effects of acetyl L-carnitine (ALC) on motor function in mice with a demyelinating condition, simulating aspects of multiple sclerosis. In this study, some mice were treated with ALC while others were not, allowing us to compare their recovery.

The results were promising; ALC not only enhanced balance and motor coordination but also supported myelin repair by lowering oxidative stress. Key genes associated with myelin were positively regulated, indicating ALC's potential as a therapeutic agent in managing autoimmune disorders like MS.

7.5

Improved brain function

Most Useful Review

135 people found this helpful

I have been ordering for several years, 500 ml of 100 pills. This product from Now is perfectly balanced. The capsules are not large and white, and the composition helps my brain function more efficiently; my drowsiness has alleviated and my overall mood has improved. I highly recommend this high-quality product.

Updated: Mar 2026

Chronic Fatigue Syndrome details

ALC reduces fatigue in elderly

Based on 4 Researches

Malaguarnera M, Gargante MP, Cristaldi E, Colonna V, Messano M, et al. Acetyl L-carnitine (ALC) treatment in elderly patients with fatigue. Arch Gerontol Geriatr. 2008;46:181.

We investigated the impacts of acetyl L-carnitine (ALC) on chronic fatigue in elderly patients, examining 96 individuals aged 70 and above. The study utilized fatigue scales to assess changes after treatment.

Results indicated that ALC significantly reduced both physical and mental fatigue while improving cognitive function and overall physical status. Participants reported a notable decrease in muscle pain and sleep disorders, alongside improvements in fatigue severity.

Overall, ALC shows promise as a treatment option for alleviating chronic fatigue in older adults.

Significant improvement.

Most Useful Review

81 people found this helpful

I suspect I have CFS, and this product improved my condition remarkably within a day. I reduced my sleep requirement from 9.5 hours to about 8.5 hours and felt more energetic with fewer headaches. Discovering that I had symptoms of CFS was surprising; I always thought I had depression, but anti-depressants weren't effective. This treatment has been a miracle for me. If you're persistently tired, give it a go—you have nothing to lose but a bit of money.

Updated: Mar 2026

Common Cold details

Reduces cold sensitivity

Although I'm on a relaxed diet, I felt stagnant until I realised this product was making a difference! I've become less sensitive to the cold compared to before, which was quite pleasant.

Updated: Mar 2025

High Cholesterol details

Highly recommended supplement

30 people found this helpful

This supplement effectively bolsters brain function and lowers cholesterol levels. I highly recommend you try it.

Pelvic Pain details

Pain-free transformation

15 people found this helpful

Nurse Approved! ✴️I used to have nerve pain that radiated from my back to my legs. I began taking it daily and now I am 💯% pain free! Having tried gabapentin and disliked the side effects, I can confidently say this is a true life-changing supplement. I work as a nurse, spending over 10 hours on my feet 3-4 days a week, yet I haven't experienced any pain regardless of the demands on my body.

I found this product excellent and am very pleased with my purchase. The capsules are easy to swallow without any taste. Previously, I used a brand with large, chalky pills that smelled terrible. Although these capsules have a slight odour, they're much more bearable and go down quickly. NAC is noted for numerous health benefits (you might like to research NAC and glycine!), but for me, the most significant advantage has been the near elimination of my previously almost migraine-level headaches. The packaging is also quite good.

Adenoiditis details

Reflux details

Caused heartburn issues

The pills are quite large and tend to induce heartburn, possibly because I have acid reflux. I haven't noticed any alterations in my weight or overall health since taking them.

Product efficiency assured

Sleep Apnea details

3 people found this helpful

This is a good product; its quality is worth the money. Fat burning during workouts is slightly quicker, and recovery along with excellent sleep is guaranteed. I could provide a more detailed review, but it’s simpler to try it and see the results for yourself. Wishing you good health!

Acetyl-L-Carnitine shows potential

Tinnitus details

Gopal KV, Thomas BP, Mao D, Lu H. Efficacy of carnitine in treatment of tinnitus: evidence from audiological and MRI measures-a case study. J Am Acad Audiol. 2015;26:311. doi:10.3766/jaaa.26.3.10

We aimed to explore if acetyl-L-carnitine (ALCAR) could alleviate tinnitus symptoms and whether improvements would reflect in audiological and MRI assessments.

In a case study involving a 41-year-old woman with hearing loss and tinnitus, we tracked changes before and after 30 days of ALCAR supplementation at 1,000 mg daily.

The results showed promising changes in both objective measures and her personal experience, suggesting ALCAR could be a beneficial treatment option for tinnitus.

Great nerve repair

Most Useful Review

2 people found this helpful

This product is excellent for nerve repair. My tinnitus noticeably improved after taking it.

Updated: Mar 2026

Mild Cognitive Impairment details

Neuroprotective Effects

Clinical studies advocate Acetyl-L-Carnitine for treating asthma, vascular dementia, mild cognitive decline, and depressive disorders in the elderly as part of comprehensive therapy.

Heartburn details

No heartburn experienced

Really amazing! More than wonderful for enhancing training efficiency, increasing male hormones, and aiding weight loss. It does not cause heartburn or acidity.

Acetyl-L-Carnitine affects hypothyroidism

Hypothyroidism details

Gadaleta MN, Petruzzella V, Fracasso F, Fernandez-Silva P, Cantatore P. Acetyl-L-carnitine increases cytochrome oxidase subunit I mRNA content in hypothyroid rat liver. FEBS Lett. 1990;277:191.

We examined how acetyl-L-carnitine influences hypothyroidism, particularly focusing on its impact on liver mitochondria. In our study, we measured the amount of messenger RNA for cytochrome oxidase subunit I in the livers of hypothyroid rats.

After treating the rats with acetyl-L-carnitine, we observed a significant increase in the mRNA levels just three hours post-treatment. This improvement in gene expression suggests that acetyl-L-carnitine may promote mitochondrial function even in altered metabolic states.

Interestingly, even rats that were pre-treated with T3, a thyroid hormone, showed similar positive effects when administered acetyl-L-carnitine. These findings lend further support to the idea that acetyl-L-carnitine can stimulate important processes in mitochondria, especially under conditions like hypothyroidism.

Feeling better

Most Useful Review

I started taking this on my endocrinologist's advice for hypothyroidism, and I feel significantly better now.

Updated: Apr 2025

Dizziness details

10 people found this helpful

Excellent! It improves brain function. I took it for recovery during long subway trips; I began to feel dizzy and light-headed. After a month of taking one capsule each morning and evening, the symptoms ceased completely. My memory and capacity for work have improved noticeably. If this was helpful, please rate my response; I would be delighted to have assisted!

Cold details