NOW Supplements L-Carnosine

Supplement Facts

Serving Size: 1 Veg Capsule

Amount Per Serving

%DV

L-Carnosine (B-alanyl-L-histidine)

500 mg

The product is found useful for the following medical conditions

We explored the neuroprotective effects of carnosine in mice exposed to a Parkinson's-like condition using MPTP. By adding varying doses of carnosine to their drinking water over four weeks, we noticed that it effectively reduced damaging oxidative stress and inflammatory responses.

Notably, carnosine preserved essential dopamine levels and improved glutathione activity, indicating its potential to protect against neurodegeneration. Overall, our findings suggest that carnosine may offer a beneficial strategy in mitigating the effects of Parkinson's disease.

8.5

Significant improvement noted

Most Useful Review

46 people found this helpful

Carnosine is truly remarkable. We have given it to our child twice, and there has been a noticeable breakthrough in their speech development, with no other changes made to their diet or medications. For an elderly relative with Parkinson's, the results are similarly impressive. They reported, "the fog in the head is gone, and there are fewer goosebumps," while continuing their standard therapy. I highly recommend trying Carnosine, as it appears quite safe unless one has serious low blood pressure or is scheduled for surgery soon. The Now Foods capsules are easy to take, being large yet manageable. I wish everyone good health!

Allergies details

Reduced allergic reactions

Most Useful Review

1 people found this helpful

Since I began this supplement, I’ve experienced a significant reduction in allergic reactions. My seasonal allergies have become much less severe, enabling me to enjoy the outdoors without the usual discomfort.

Autism details

SCIENTIFIC SCORE

Questionable

Based on 10 Researches

Assessing L-Carnosine's effectiveness for ASD

Abraham DA, Undela K, Narasimhan U, Rajanandh MG. Effect of L-Carnosine in children with autism spectrum disorders: a systematic review and meta-analysis of randomised controlled trials. Amino Acids. 2021;53:575. doi:10.1007/s00726-021-02960-6

We systematically reviewed studies to understand how L-Carnosine might help children with autism spectrum disorders (ASD). Our focus was on randomized controlled trials, which are the gold standard in research, ensuring that results are reliable.

The research included four double-blinded, placebo-controlled trials and one open-label trial, totaling 215 participants. We assessed the effectiveness of L-Carnosine in improving social, communication, and behavioral skills, as well as addressing sleep disorders and gastrointestinal issues. While we hoped to find promising results, the meta-analysis revealed no significant improvements when comparing L-Carnosine to placebo.

Specifically, measures like the Gilliam Autism Rating Scale and the Childhood Autism Rating Scale showed no notable differences between the two groups. Current evidence does not support the use of L-Carnosine as an effective treatment for ASD in children, highlighting the need for further research and a larger array of studies in this area.

Great behaviour control

Most Useful Review

53 people found this helpful

I deemed this supplement worthwhile after some research. I have two sons; one with autism. This supplement has markedly increased my son's therapy reports and improved his control over behaviour and emotions. Additionally, my seven-year-old has now consistently slept through the night for three weeks.

Tinnitus details

Reduced tinnitus symptoms

Most Useful Review

4 people found this helpful

I have tinnitus caused by an autonomic nervous disorder, and I've been taking this supplement. My condition has improved significantly; at times, I only hear a faint ringing in my ears. I plan to continue taking it regularly for the foreseeable future.

Adhd details

l-Carnosine shows potential in ADHD

Ghajar A, Aghajan-Nashtaei F, Afarideh M, Mohammadi MR, Akhondzadeh S. l-Carnosine as Adjunctive Therapy in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. J Child Adolesc Psychopharmacol. 2018;28:331. doi:10.1089/cap.2017.0157

This study looked into how effective l-carnosine can be when added to standard ADHD medication, methylphenidate. Over eight weeks, we monitored 56 children with ADHD, comparing those given l-carnosine to those receiving a placebo. Some positive results appeared in parent-rated attention measures, indicating that l-carnosine might offer some benefit. However, improvements were not seen in teacher assessments, suggesting limited effects overall. While the findings show promise, more research is needed to confirm these results and explore different dosages.

7.5

Improved morning wakefulness

Most Useful Review

8 people found this helpful

It became easier to wake up in the morning after I began taking Ajinomoto's "Every morning histidine," which contains 1650mg of the ingredient. For two years, I've struggled to get up due to my possible ADHD, often oversleeping for more than 15 hours on holidays. Although it's not a complete solution, I’ve noticed significant improvement since starting this.

Alzheimer details

SCIENTIFIC SCORE

Possibly Effective

Based on 16 Researches

Carnosine's potential against Alzheimer's

Joshi P, Perni M, Limbocker R, Mannini B, Casford S, et al. Two human metabolites rescue a C. elegans model of Alzheimer's disease via a cytosolic unfolded protein response. Commun Biol. 2021;4:843. doi:10.1038/s42003-021-02218-7

We discovered interesting insights into how l-carnosine, an endogenous metabolite, impacts Alzheimer's disease. By analyzing data from the Human Metabolome Database, we identified l-carnosine, alongside kynurenic acid, as substances that can inhibit the aggregation of amyloid beta peptide (Aβ), which is commonly associated with Alzheimer’s.

Our findings highlighted that l-carnosine works by triggering a cytosolic unfolded protein response. This involves a transcription factor called HSF-1 and different chaperones, specifically HSP40/J-proteins DNJ-12 and DNJ-19. This mechanism indicates that l-carnosine not only plays a role in reducing protein aggregation but may also suggest potential anti-aging benefits.

The link we established between metabolite homeostasis and protein homeostasis presents promising avenues for preventative measures against neurodegenerative disorders. It's exciting to think about how exploring the roles of metabolites like l-carnosine could offer new strategies in combating diseases that impact so many lives.

Increased energy levels

Most Useful Review

169 people found this helpful

My get-up-and-go had gone, but it's back! I first heard of this on Dr Oz, prompting me to research it further. Many reputable sources noted its claims and results from studies. Although a bit pricey, I decided to try it. I genuinely feel more energised after taking it, 1000mg daily. I even mix it into a tall glass of water. I'm not a doctor, so always consult a professional before relying on online information. My energy and motivation have significantly improved, which has led to better food choices and reduced sugar cravings.

Cardiovascular Disease details

Energy boost during training

Most Useful Review

Effective in cardiovascular disease; this product has been tested through long-term use and also provides energy during training.

High Cholesterol details

Normalised cholesterol

Most Useful Review

2 people found this helpful

I take 1 capsule per day, 500 mg with alpha lipoic acid, 100 mg. Both antioxidants complement one another. After a three-month treatment, my cholesterol normalised from 8.5 to 5 units. I have felt a surge of energy, and my mood has improved. Additionally, I also take Vit. D and L-optiZink in consultation with my doctor.

Hot Flashes details

23 people found this helpful

I am already purchasing a second can. Having been in menopause for six months, I endured frequent hot flashes, particularly at night. Discovering this medication was a revelation for me; the hot flashes have now become infrequent and much milder. I highly recommend giving it a try.

Kidney Stones details

Improved energy levels

Most Useful Review

Excellent, necessary for many food supplements. L-carnosine serves as a building block for protein. After a month of taking it, my metabolism improved. It supports the functioning of the heart, kidneys, and stomach. I've noticed increased energy, an uplifted mood, and enhanced performance. The capsules are medium-sized, odourless, and easy to swallow.

Mild Cognitive Impairment details

Tremor relief experienced

Most Useful Review

4 people found this helpful

The tremor issue has vanished! It is highly effective for elderly individuals with Mild Cognitive Impairment, especially when combined with DHA and Phosphatidylserine. The previous hand tremor problem disappeared. As a potent antioxidant found primarily in meat, it supports brain health, maintains muscle and nervous system function, and prevents the excessive accumulation of beta-amyloid plaques that impair brain cell signalling.

Pelvic Pain details

69 people found this helpful

Amazing supplement! I have been taking this for about two months for my Post-Polio syndrome and arthritis. My pain is gone, my muscles are stronger, and I feel steadier on my feet. It’s truly amazing. I’m almost hesitant to acknowledge how much better I feel for fear of breaking the spell that this L-Carnosine has cast upon me. I am very grateful to have discovered it and take two 500 mg daily.

Sleep Apnea details

Energy levels increased

Most Useful Review

11 people found this helpful

After one month on this drug, I experienced decreased fatigue and increased energy, allowing for quicker recovery after exertion. I didn’t observe significant anti-aging effects but bought it for my mother, who was satisfied as well. The only downside is its cost, particularly for continuous use.

Autoimmune Disorder details

3 people found this helpful

I ordered this at my mother's request and am sharing her experience. After completing the course, her blood pressure normalized, and she was less affected by weather changes. Additionally, her memory improved, and mood swings stabilised, which is wonderful news for her. I highly recommend this as a general strengthener for the elderly.

Diabetes details

SCIENTIFIC SCORE

Questionable

Based on 16 Researches

Carnosine shows no effectiveness

Saadati S, Jansons P, Scott D, de Courten M, Mousa A, et al. The Effect of Carnosine Supplementation on Musculoskeletal Health in Adults with Prediabetes and Type 2 Diabetes: A Secondary Analysis of a Randomized Controlled Trial. Nutrients. 2024;16. doi:10.3390/nu16244328

We investigated the effects of l-carnosine supplementation on musculoskeletal health in adults with prediabetes and type 2 diabetes (T2D). In a well-structured clinical trial, 49 participants, all without pre-existing musculoskeletal issues, were divided into two groups. One group received 2 grams of l-carnosine daily for 14 weeks, while the other was given a placebo.

After completing the study, we found that carnosine supplementation did not lead to any significant improvements. There were no notable changes in muscle strength or body composition between those taking l-carnosine and those on the placebo. Specifically, metrics such as hand grip strength, lean mass, fat percentage, and bone health markers showed no benefits from the supplement.

Our findings suggest that l-carnosine might not be a helpful strategy for enhancing musculoskeletal health in individuals with prediabetes and T2D. While our study was comprehensive, further research with larger participant numbers and longer durations would ultimately be needed to confirm these results.

Controlled diabetes levels

Most Useful Review

52 people found this helpful

Amazing. My nutritionist recommended L-Carnosine when I had a slow-healing wound due to diabetes. Combined with exercise, I experienced full recovery, and my HbA1c level dropped to 5.7. While I can't say my diabetes is reversed, my sugar levels are certainly managed, so I continue taking it alongside Vitamin C for immune support.

Ulcer details

SCIENTIFIC SCORE

Moderately Effective

Based on 13 Researches

Zinc l-carnosine promotes ulcer healing

Ooi TC, Chan KM, Sharif R. Antioxidant, Anti-inflammatory, and Genomic Stability Enhancement Effects of Zinc l-carnosine: A Potential Cancer Chemopreventive Agent?. Nutr Cancer. 2017;69:201. doi:10.1080/01635581.2017.1265132

We investigated how zinc l-carnosine (ZnC) might affect ulcers, focusing on its potential as an effective treatment. The research highlighted ZnC's use in clinical settings, especially in Japan, where it is already employed to tackle gastric ulcers.

Through various studies, we learned that ZnC exhibits strong antioxidant and anti-inflammatory properties, which are key factors in healing ulcers. By working to reduce oxidative stress and inflammation, ZnC appears to create a more favorable environment for ulcer healing.

Moreover, the research points toward ZnC's ability to enhance genomic stability, which might further strengthen its role in preventing complications associated with ulcers. Overall, the findings suggest that ZnC could be a promising option for those suffering from gastric ulcers, enhancing the healing process and potentially improving patient outcomes.

Improved ulcers significantly

Most Useful Review

1 people found this helpful

I've suffered from gastric ulcers for years, but since taking this with traditional Chinese medicine, my symptoms have notably improved.

Depression details

4 people found this helpful

It works for depression! My depression has significantly reduced since I started taking it. The synergistic effect of combining it with supplements like B vitamins, vitamin C, vitamin E, and niacin has proven beneficial.

Flu details

SCIENTIFIC SCORE

Possibly Effective

Based on 3 Researches

L-Carnosine's role in flu treatment

Babizhayev MA, Deyev AI, Yegorov YE. Non-hydrolyzed in digestive tract and blood natural L-carnosine peptide ("bioactivated Jewish penicillin") as a panacea of tomorrow for various flu ailments: signaling activity attenuating nitric oxide (NO) production, cytostasis, and NO-dependent inhibition of influenza virus replication in macrophages in the human body infected with the virulent swine influenza A (H1N1) virus. J Basic Clin Physiol Pharmacol. 2013;24:1. doi:10.1515/jbcpp-2012-0037

We observed that L-carnosine, a natural peptide, shows promise in addressing influenza A virus infections, particularly the problematic H1N1 strain. This study highlights how L-carnosine can potentially influence the immune response during flu infections, which is crucial given the virus's ability to evade our defenses.

The effects of L-carnosine include the reduction of harmful nitric oxide production and the inhibition of virus replication in infected cells. Essentially, L-carnosine may act as a protective agent against the cellular damage typically caused by the flu virus. By helping to modulate the immune response, it might also aid in reducing symptoms and complications associated with flu infections.

Additionally, the study emphasizes the significance of L-carnosine's non-hydrolyzed forms, which maintain their effectiveness in the digestive tract and bloodstream, making them particularly beneficial for oral supplementation. Products derived from chicken extracts, noted for their high L-carnosine content, could be part of a preventive approach to flu.

Overall, L-carnosine appears to be a strong candidate in flu treatment strategies, especially given its ability to mitigate severe immune responses that can lead to complications in vulnerable populations.

Improves immunity

Most Useful Review

This vitamin is excellent; my immunity is strong, and I no longer have the flu. My doctor recommended this brand, and I am very pleased with it.

Blood Clot details

Improves speech delay

Most Useful Review

46 people found this helpful

I've been using Carnosine, and I'm pleased with the results. A child with speech development delays experienced a breakthrough while on it without any dietary changes or other medications. Carnosine was also beneficial for an elderly person with Parkinson’s disease, who reported cognitive clarity and reduced symptoms. The capsules are large but easy to swallow. I recommend trying Carnosine, as it seems to be safe unless you have severe low blood pressure or are preparing for surgery soon. Wishing everyone good health!

Heart Attack details

Heart health improved

Most Useful Review

3 people found this helpful

After using this, my autonomic imbalance improved, and I feel revitalised. My heart has become healthy, and my body feels refreshed. The supplement's size is comparable to others I've tried.

Brain Tumor details

Mood and memory improved

Most Useful Review

47 people found this helpful

I was introduced to carnosine by my dietician while managing a diet that affected my memory. Within weeks of taking it, my mood improved significantly, and I no longer experienced fatigue or sluggishness. This product remarkably enhanced my cognitive functions and I highly recommend it for maintaining brain health.

Atrial Septal Defect details

Improved sleep quality

Most Useful Review

9 people found this helpful

This medication has been effective for my child with ASD, who previously struggled with sleep. Thanks to this treatment, his sleep patterns have improved significantly. According to studies involving numerous participants, it led to enhancements in communication, socialisation, and behaviour. I have now purchased three cans as I continue to witness notable progress.

Adenoiditis details

Morning movement improved

Most Useful Review

3 people found this helpful

I noticed the effects the very next day. My low blood pressure often hinders my ability to get up in the morning, but after starting this supplement for adenoiditis, it became easier to move around! However, I find the capsules quite large, which makes them difficult to swallow. Hence, I've given it 4 stars.

Blurred Vision details

51 people found this helpful

I can see well and feel less tired! I have suffered from irritable bowel syndrome for about two years and have various physical issues that made me feel low. I thought these problems stemmed from my autonomic nerves, so I sought a supplement to aid them and found L-carnosine. While I didn't notice immediate changes, after three days, I realised I could see better! Although I had LASIK over a decade ago, my eyesight degraded, and driving at night required glasses. Now, I can drive without them, and my field of vision appears brighter. Reading small text is easier without glasses at work. Additionally, I feel less fatigued overall. Despite still having some symptoms like irritable bowel syndrome, my overall well-being has greatly improved, and I intend to continue taking it.

Chronic Fatigue Syndrome details

L-carnosine shows limited benefits

Baraniuk JN, El-Amin S, Corey R, Rayhan R, Timbol C. Carnosine treatment for gulf war illness: a randomized controlled trial. Glob J Health Sci. 2013;5:69. doi:10.5539/gjhs.v5n3p69

We conducted a randomized controlled trial to explore whether L-carnosine could significantly improve symptoms associated with Gulf War illness (GWI), a condition characterized by disabling fatigue, pain, and cognitive dysfunction.

In this 12-week study, 25 individuals suffering from GWI were given L-carnosine in increasing doses of 500 mg, 1000 mg, and finally 1500 mg, administered at four-week intervals. We utilized a double-blind and placebo-controlled design, which is a strong method for assessing treatment efficacy.

Our observations revealed that while L-carnosine seemed to have a positive effect on cognitive function, as indicated by improved scores on the WAIS-R test, it did not show significant improvements in fatigue, pain, or overall activity levels. Interestingly, there was a reduction in diarrhea linked to irritable bowel syndrome, which is a positive note for gastrointestinal health.

Overall, while L-carnosine may offer some cognitive benefits, it appears that other major symptoms of chronic fatigue associated with GWI remain resistant to this treatment.

Pain relief

Most Useful Review

11 people found this helpful

I’m glad I bought this. Nearing 60, I’ve experienced chronic fatigue syndrome, muscle fatigue, and pain. After taking it with ADAM and Omega 3, my pain and numbness disappeared. It genuinely works, and I slept well.

Liver Disease details

2 people found this helpful

I took this supplement to enhance liver function as Carnosine is known to assist in removing heavy metals and reducing glycation. I experienced no side effects, and the capsules are easy to consume.

Cataract details

SCIENTIFIC SCORE

Moderately Effective

Based on 16 Researches

N-Acetyl Carnosine enhances cataract treatment

Wang L, Liu W, Huang X. An approach to revolutionize cataract treatment by enhancing drug probing through intraocular cell line. Libyan J Med. 2018;13:1500347. doi:10.1080/19932820.2018.1500347

Our exploration focused on the potential of N-Acetyl Carnosine (NAC) in treating cataract, a condition that occurs when proteins in the eye become insoluble and form large masses. Traditional cataract surgeries often require expensive equipment and skilled mediators, so we sought a less invasive solution through the use of solid lipid nanoparticles (SLN).

We prepared SLN-NAC using a unique method known as Mill's method, resulting in particles measuring around 75 nanometers—the ideal size for effective eye penetration. The formulation demonstrated a sustained release of the active ingredient over 24 hours, following a rapid initial release after just one hour.

Our studies also indicated that SLN-NAC penetrated the cornea more effectively than standard NAC eye drops, while corneal hydration tests showed no damage to corneal cells. This suggests that SLN-NAC may offer a promising breakthrough in cataract treatment by enhancing drug delivery and minimizing toxicity.

Overall, the compelling results lead us to believe that SLN-NAC could significantly improve the way cataracts are treated, offering a practical alternative to surgical interventions.

7.5

Seems effective

Most Useful Review

17 people found this helpful

This product seems to be helping with my cataract. Although it’s still a bit early to fully celebrate, it does appear to be making a difference.

NOW Supplements L-Carnosine

The product is found useful for the following medical conditions

Cold Sores details

Chronic Cough details

Adrenal Gland Disorder details

Back Pain details

Knee Pain details

Leg Cramps details

Menopause details

Parkinson details

Allergies details

Autism details

Tinnitus details

Adhd details

Alzheimer details

Cardiovascular Disease details

High Cholesterol details

Hot Flashes details

Kidney Stones details

Mild Cognitive Impairment details

Pelvic Pain details

Sleep Apnea details

Autoimmune Disorder details

Diabetes details

Ulcer details

Depression details

Flu details

Blood Clot details

Heart Attack details

Brain Tumor details

Atrial Septal Defect details

Adenoiditis details

Blurred Vision details

Chronic Fatigue Syndrome details

Liver Disease details

Cataract details