NOW Supplements Nattokinase

7 people found this helpful

I bought nattokinase for my mother, who previously relied on thromboass. After just a week, she experienced remarkable changes: her blood pressure normalised, and she could now stand on her knees without pain, which she hadn’t been able to do for a long time. She is thrilled with this result, and I’m grateful to iHerb for this incredible product.

Pelvic Pain details

22 people found this helpful

I have a history of very painful periods. Recently, they have been occurring every two weeks along with severe breakouts, which left me quite distressed. After consulting a doctor, I found that I had a cyst on my ovary and "uneven uterine lining," potentially indicating fibroids. Seeking alternatives to taking the pill, I tried nattokinase, serrapeptase, and DIM. Although I experienced some mild cramping, which is common, I have noticed positive changes. It has been a month, and my cycle now arrives at the 27-day mark without any pain, heaviness, or bloating. Furthermore, I feel less exhausted and irritable, with virtually no breakouts. It has been transformative for me so far.

Tinnitus details

Stable blood pressure

11 people found this helpful

Works brilliantly! I purchase this medication for my mother, as advised by our naturopath. My mother has hypertension, high blood pressure, and a history of strokes. This medication effectively thins the blood, preventing blood clot formation. She experienced the benefits quite quickly; dizziness, headaches, and tinnitus diminished. Her blood pressure has stabilised, with no surges or crises for a month now, which is an excellent outcome for her! We will continue with it! I have not experienced any side effects, and my health, wellbeing, and energy are at their peak! If you found my review helpful, please give it a Like 🙏

Arthritis details

Less arthritis symptoms

Excellent supplement with high-quality ingredients. The dosage and administration method are clearly described on the packaging. The taste is neutral, and the size is just right. The benefits are visible very quickly; migraines and headaches disappear, and issues with joints diminish, which has resulted in much less arthritis symptoms. It helps significantly with bone and joint problems. This supplement is excellent, and I plan to purchase more.

Blood Clot details

Nattokinase shows strong clot-busting activity

Based on 18 Researches

Modi A, Raval I, Doshi P, Joshi M, Joshi C, et al. Heterologous expression of recombinant nattokinase in Escherichia coli BL21(DE3) and media optimization for overproduction of nattokinase using RSM. Protein Expr Purif. 2023;203:106198. doi:10.1016/j.pep.2022.106198

We explored the effectiveness of nattokinase, a natural enzyme known for its role in breaking down blood clots, by studying its production and activity in a lab setting. Nattokinase was extracted from Bacillus subtilis, and we introduced this gene into E. coli bacteria to produce the enzyme at high levels.

Through our process, we purified the active recombinant nattokinase and tested its ability to dissolve blood clots. Our results were promising; the enzyme exhibited a fibrinolytic activity of 58FU/mg, which is notably five times more effective than the currently used drug, orokinase.

We optimized the conditions for producing nattokinase, including factors like temperature and nutrient concentrations, resulting in an impressive yield of 1805.50 mg/L. This improved production method paves the way for scaling up nattokinase's use in treating cardiovascular diseases related to blood clots. The findings emphasize nattokinase's potential as an effective thrombolytic agent.

Eliminated headache

Most Useful Review

151 people found this helpful

I highly recommend it! The swelling has gone down, and my blood is flowing well. I began taking it during the pandemic and since then, I've not had a headache, which is remarkable for me.

Chronic Fatigue Syndrome details

Enhanced overall well-being

Excellent! It improves well-being, alleviates fatigue, and positively affects the heart and blood vessels.

Cold details

Nattokinase aids cold recovery

Nara N, Kurosawa Y, Fuse-Hamaoka S, Kuroiwa M, Endo T, et al. A single dose of oral nattokinase accelerates skin temperature recovery after cold water immersion: A double-blind, placebo-controlled crossover study. Heliyon. 2023;9:e17951. doi:10.1016/j.heliyon.2023.e17951

We conducted a study to explore how a single dose of nattokinase (NK) influences recovery of skin temperature after exposure to cold water. This double-blind, placebo-controlled crossover study involved nine healthy men who took either NK or a placebo before submerging their hands in ice-cold water at 10 °C for one minute.

Our findings showed that participants who took NK experienced a quicker recovery of skin temperature in their middle finger, palm, and back of the hand compared to those who took the placebo. Although cold exposure initially caused a significant drop in skin temperature, the NK appeared to accelerate the warming process afterward.

Interestingly, we did not observe any changes in heart rate, cardiac output, or sympathetic nervous activity as a result of taking NK. This is noteworthy because it suggests that while NK may help with temperature recovery, it does not impact certain cardiovascular responses typically associated with cold exposure.

Overall, our study highlights the potential benefits of nattokinase, especially for individuals who are more sensitive to cold, such as women and the elderly. It could offer a new avenue for managing cold sensitivity and minimizing excessive vasoconstriction during chilly conditions.

Effective immune support

Most Useful Review

Hello everyone! I truly trust this brand's supplements! I've tried various ones, all of excellent quality! Reasonable price, great ingredients, and good formulation. I bought this product as immune support during colds. It fulfils this role perfectly. The packaging is convenient, and the lid closes securely. The capsules are of standard size, making them easy to use.

Constipation details

Helps intestinal function

Good medication! I purchase it for my mother, who takes it to thin her blood. I've witnessed the dosage change from four capsules a day to two. Alongside thinning the blood, the medication also improves intestinal function and helps relieve constipation. There is definitely a noticeable benefit from this drug.

Dizziness details

An excellent product! It genuinely works! Merely two days after starting the treatment, my dizziness disappeared, and the ringing in my ears reduced. I suffered this due to thick blood. I have become less sensitive to changing weather. The price is reasonable, and the number of capsules is ample. I shall continue using them!

Menopause details

A good drug that helps prolong ovarian function and delays menopause without hormones, which is important! The price and quality are pleasantly surprising. I recommend it.

Athlete’s Foot details

This is the first time I purchased a trial. I usually feel numbness in my feet after using the toilet, as if there’s no blood flow. After taking it, that sensation has disappeared. It seems effective at unblocking my blood vessels. Thank you.

Cancer details

Nattokinase may inhibit liver cancer

Based on 4 Researches

Yan Y, Wang Y, Qian J, Wu S, Ji Y, et al. Nattokinase Crude Extract Inhibits Hepatocellular Carcinoma Growth in Mice. J Microbiol Biotechnol. 2019;29:1281. doi:10.4014/jmb.1812.12058

We assessed the impact of nattokinase crude extract (NCE) on liver cancer, specifically hepatocellular carcinoma (HCC), using mouse models.

Mice receiving NCE exhibited a 31% survival rate improvement and reduced tumor sizes, as indicated by imaging and pathology evaluations.

Additionally, NCE led to decreased levels of several cancer markers.

Overall, these findings suggest that nattokinase may positively influence liver cancer outcomes in this model.

7.5

Helps blood cancer

Most Useful Review

12 people found this helpful

Wonderful! We use this instead of aspirin. My husband has a blood cancer that increases the viscosity of his blood, making it thicker, and this is certainly helping.

Candidiasis details

Wonderful! Used in the anti-Candidiasis protocol alongside other methods, it truly helps!

Chest Pain details

My heart pain has ceased, and I feel better blood flow after starting this. Definitely recommending it!

Food Poisoning details

7 people found this helpful

I like this product so far; this is the second time I've purchased it. After a TIA, I experienced significant numbness on the right side of my neck and was informed by a doctor that my blood was thick. Since I have been taking Nattokinase, the numbness in my neck has greatly reduced. I still experience slight numbness in my tongue, but that's improved as well. I plan to continue using this product.

Heart Attack details

Nattokinase shows promise for hearts

Based on 2 Researches

Chandrasekaran SD, Vaithilingam M, Shanker R, Kumar S, Thiyur S, et al. Exploring the In Vitro Thrombolytic Activity of Nattokinase From a New Strain Pseudomonas aeruginosa CMSS. Jundishapur J Microbiol. 2015;8:e23567. doi:10.5812/jjm.23567

We aimed to explore the effectiveness of nattokinase, an enzyme with potent fibrinolytic properties, in treating heart attacks. Through our research, we focused on enhancing the production of nattokinase from a newly identified strain of Pseudomonas aeruginosa, referred to as CMSS, which we isolated from cow milk.

Our comprehensive study involved optimizing different growth conditions such as pH, temperature, and nutrient sources, alongside improving the strain through UV-mutagenesis. We were excited to find that these optimizations led to a significant increase in nattokinase production.

The standout results showed that our modified strain produced nattokinase with a maximum activity of 4263 U mL(-1), which is double that of the original strain. In practical terms, this nattokinase achieved an impressive 94% blood clot lysis within ten minutes, hinting at its potential as a rapid acting treatment for heart-related issues.

Overall, our findings suggest that nattokinase from Pseudomonas aeruginosa CMSS could be a promising candidate for thrombolytic therapy, notably for those at risk of acute myocardial infarction. This unique study represents the first report of nattokinase production from this microorganism, opening the door to further research.

Cardiovascular support

Most Useful Review

12 people found this helpful

Nattokinase is an excellent supplement for preventing heart attacks and strokes. For nine years, I have taken it and highly recommend it, especially after having experienced a heart attack and numerous TIA strokes. It is a reliable choice for supporting cardiovascular health.

Sinusitis details

1 people found this helpful

It reduces sinusitis and lowers pressure. I've been using it recently.

Sleep Apnea details

Significant improvement

I suffer from severe side effects due to a reaction to the antibiotic Levaquin. One of the most distressing issues is electric shocks in my legs, which rob me of sleep and are excruciating. My doctor recommended Nattokinase, and it has indeed helped. Though I still experience the shocks at times, the improvement is considerable, and I am immensely grateful.

Autoimmune Disorder details

6 people found this helpful

We've used nattokinase as a family for three years, preferring this brand over others we've tried. I ordered it to help normalise my blood pressure and to manage my husband's blood clots. After just a few days, I realised my hand numbness had decreased, and my husband has stable blood pressure. We're delighted with these results!

Heart Disease details

Nattokinase shows promise for heart attacks

Shi Y, Liu C, Gui Y, Guo Y, Zhang Y, et al. A Nattokinase-Loaded Nanozyme for Alleviating Acute Myocardial Infarction via Thrombolysis and Antioxidation. Adv Healthc Mater. 2024. doi:10.1002/adhm.202402763

We explored the potential of a novel treatment using nattokinase combined with manganese oxide nanozymes to tackle acute myocardial infarction caused by blood clots. This innovative approach aims to enhance thrombolytic therapy and combat oxidative stress. The study found that injecting this nattokinase-loaded nanozyme significantly restored blood flow and reduced heart damage in mouse models of heart attacks. While the results are promising, suggesting a new avenue for treatment, further research is necessary to establish its effectiveness in humans.

Improves Lyme disease

Most Useful Review

14 people found this helpful

Natto is an excellent blood thinner with no side effects. Nattokinase effectively reduces fibrins and improves blood circulation. My daughter, who has Lyme disease, experienced significant improvements after using it, enhancing the effectiveness of her herbal remedies. Thanks to iHerb for providing this at a fair price!

Irritable Bowel Syndrome details

This supplement is essential for maintaining healthy circulation and can aid digestion, making bowel movements smoother when taken after meals.

Leg Cramps details

15 people found this helpful

I highly recommend Nattokinase! This is my second order, and the quality remains outstanding. It has greatly aided my recovery after Covid by thinning my blood and reducing fibrin levels. With regular use, I've noticed the swelling in my legs has diminished significantly, and I feel much better overall. I experience fewer headaches and my bowel movements have normalised. I take two capsules a day, and it’s made a noticeable difference—I'm genuinely pleased and I hope my review helps others!

Allergies details

Nattokinase identified as allergen

Suzuki K, Nakamura M, Sato N, Futamura K, Matsunaga K, et al. Nattokinase (Bac s 1), a subtilisin family serine protease, is a novel allergen contained in the traditional Japanese fermented food natto. Allergol Int. 2023;72:279. doi:10.1016/j.alit.2022.11.010

We examined the effects of nattokinase, a protease found in natto, on allergies. Our study involved eight individuals who experienced allergic reactions after consuming natto, specifically the sticky substance surrounding the beans. Some participants tested negative for polygamma glutamic acid (PGA), which was previously identified as a potential allergen.

Throughout our investigation, we employed skin prick tests, immunoblotting, and ELISA to assess the reactivity to nattokinase and other components. Notably, we discovered that a subset of patients, particularly those who were negative for PGA, exhibited an allergic response to nattokinase. This finding suggests that nattokinase may act as a distinct allergen in certain individuals.

In the end, we identified nattokinase as a new allergen linked to natto allergy, particularly in those not sensitized to PGA. While our study highlights the allergenic potential of nattokinase, its broader implications for allergy treatment remain to be fully explored.

Effective, subtle impact

Most Useful Review

Excellent product, no allergies or anything like that. The effects are not immediately noticeable, but I believe it works.

Cardiovascular Disease details

Nattokinase shows no cardiovascular benefit

Possibly Effective

Based on 10 Researches

Hodis HN, Mack WJ, Meiselman HJ, Kalra V, Liebman H, et al. Nattokinase atherothrombotic prevention study: A randomized controlled trial. Clin Hemorheol Microcirc. 2021;78:339. doi:10.3233/CH-211147

We examined how nattokinase affects the progression of atherosclerosis and related biomarkers in a double-blind trial involving 265 participants averaging 65 years old, who had no cardiovascular disease. Participants received either nattokinase or a placebo for three years.

Our findings revealed that nattokinase had no significant effect on subclinical atherosclerosis progression, blood pressure, or other laboratory measures. This indicates that nattokinase may not provide the anticipated cardiovascular benefits in healthy individuals at low risk for heart disease.

Supports heart health

Most Useful Review

30 people found this helpful

Nattokinase, derived from fermented soy, has shown promise in clinical studies for promoting heart and circulatory health. It dissolves excess fibrin in blood vessels, improves circulation, and reduces the risk of severe thrombus formation. Additionally, it lowers bad LDL cholesterol and encourages good HDL cholesterol, reduces blood viscosity, and lowers blood pressure. I’ve been taking it consistently for over four months, and it has helped significantly, especially among those over 55 who often suffer from cardiovascular diseases.

Swollen Lymph Nodes details

Oedema reduced noticeably

My mother had swollen legs for two years without any identifiable cause from various tests. After using nattokinase, her swelling noticeably diminished and has not returned. She takes it in two-week courses and has found it a reliable herbal remedy, even using it as an alternative to Aspirin after her covid recovery.

Bacterial Infection details

Gum bleeding resolved

1 people found this helpful

After having covid, I've found that this supplement works well. Drinking it on an empty stomach helps thin my blood and remove microthrombi. I noticed my gums were bleeding, but taking this supplement managed to resolve that.

Chronic Cough details

Helps reduce coughing

It thins the blood and restores blood vessel function, essential after K. It's particularly advantageous for those with cold hands and feet, frequent headaches, and blood pressure increases with weather changes. It also benefits those with a wet cough by aiding in thinning phlegm and individuals with blood vessel issues, cholesterol plaques, and a tendency for thrombosis. Some studies suggest it may help slightly with migraines.

High Cholesterol details

Nattokinase shows mixed cholesterol benefits

Possibly Effective

Based on 2 Researches

Liu X, Zeng X, Mahe J, Guo K, He P, et al. The Effect of Nattokinase-Monascus Supplements on Dyslipidemia: A Four-Month Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Nutrients. 2023;15. doi:10.3390/nu15194239

This study examined whether nattokinase monascus supplements could effectively lower cholesterol levels in people facing dyslipidemia. In a randomized trial with 113 participants, we noted significant reductions in total cholesterol, LDL cholesterol, and similar lipid markers after 120 days of using the supplements compared to a placebo.

However, we didn't see any notable improvements in triglycerides, HDL cholesterol, or carotid intima-media thickness. Importantly, participants experienced no major side effects from the treatment. Overall, while nattokinase supplements showed promise for some cholesterol levels, they did not deliver significant changes in all examined lipid factors.

Supports heart health

Most Useful Review

30 people found this helpful

Nattokinase is an enzyme derived from fermented soy products and is known to dissolve excess fibrin and improve circulation, reducing clot risks. It also lowers bad LDL cholesterol while raising good HDL cholesterol, improves blood viscosity, and regulates blood pressure. Given the prevalence of cardiovascular diseases after age 55, this supplement is vital. I have been taking it for over four months and it has positively impacted my blood consistency.

Stroke details