NOW Supplements Choline &amp; Inositol

Inositol enhances rapeseed cold tolerance

Based on 6 Researches

Yan L, Zeng L, Raza A, Lv Y, Ding X, et al. Inositol Improves Cold Tolerance Through Inhibiting and Increasing Ca Influx in Rapeseed ( L.). Front Plant Sci. 2022;13:775692. doi:10.3389/fpls.2022.775692

We explored the impact of inositol on cold stress in rapeseed, an essential oilseed crop affected by low temperatures. Notably, we found that inositol plays a significant role in enhancing cold tolerance in these plants by boosting calcium ion (Ca) influx.

Our study involved identifying various genes associated with inositol and analyzing their expression under cold conditions. Interestingly, inositol appeared to inhibit the expression of calcineurin B-like genes, which are involved in regulating calcium flow, suggesting a unique pathway through which inositol aids in cold resilience.

Additionally, when we overexpressed certain genes linked to calcium flux, we noted a stronger response to cold stress, further emphasizing the importance of the inositol-Ca pathway in facilitating cold tolerance in rapeseed. These findings not only deepen our understanding of how rapeseed copes with cold conditions but also present a potential strategy for enhancing crop resilience in the face of climate challenges.

9.5

Restored normal breathing

Most Useful Review

After frequent colds, my sense of smell decreased—it didn't vanish, merely dulled, with one nostril often blocked. However, my nose eventually began to breathe! I could finally perceive all the scents while walking down the street—the aroma of grass and flowers. At home, I even detected the smell of shower gel! What a joy it is to breathe normally! Thank you!!

Liver Disease details

Myo-inositol improves insulin resistance

Aghajani T, Arefhosseini S, Ebrahimi-Mameghani M, Safaralizadeh R. The effect of myo-inositol supplementation on AMPK/PI3K/AKT pathway and insulin resistance in patients with NAFLD. Food Sci Nutr. 2024;12:7177. doi:10.1002/fsn3.4267

We conducted a double-blinded, placebo-controlled clinical trial to explore how myo-inositol (MI) influences insulin resistance (IR) among obese individuals with non-alcoholic fatty liver disease (NAFLD). Our study involved 48 participants who were randomly assigned to receive either 4 grams of MI or a placebo daily for eight weeks.

Throughout this period, we measured various parameters such as weight, serum glucose levels, and insulin sensitivity indices before and after the intervention. Notably, we found that MI supplementation led to significant improvements in the expression levels of key genes related to the AMPK/PI3K/AKT signaling pathway, which plays a crucial role in regulating metabolism.

The results indicated noteworthy enhancements in insulin resistance for those who received MI, measured through multiple indices, reinforcing its potential benefits for liver health management. Thus, we observed that supplementing with myo-inositol not only bolstered the expression of important metabolic genes but also helped improve insulin resistance in our participants with NAFLD.

9.5

Improved liver function

Most Useful Review

This supplement was prescribed to enhance my liver health, addressing discomfort in my right hypochondrium. Although tests were normal, there were some changes indicating liver disease. The product comprises natural ingredients, and I found it easy to take. The pain and heaviness have vanished, and my digestion has improved significantly. My follow-up tests showed stabilised indicators.

Weight Loss details

Questionable

Myo-inositol aids insulin sensitivity

Genazzani AD, Prati A, Santagni S, Ricchieri F, Chierchia E, et al. Differential insulin response to myo-inositol administration in obese polycystic ovary syndrome patients. Gynecol Endocrinol. 2012;28:969. doi:10.3109/09513590.2012.685205

We investigated how myo-inositol affects insulin sensitivity and weight in obese women with polycystic ovary syndrome (PCOS). After 8 weeks of treatment with 2 grams daily, we observed a decrease in body mass index, insulin resistance, and several hormonal levels. Interestingly, women with higher initial insulin levels experienced the most significant improvements, particularly in their fasting insulin levels. This suggests that myo-inositol may be especially beneficial for those struggling with elevated insulin in conjunction with PCOS.

9.5

Effective for anxiety

Most Useful Review

I'm pleased with the effects of this vitamin combination. Choline and Inositol significantly benefit mental health, fostering the production of mood-regulating hormones. They are advisable for those facing obesity, improving metabolism and stimulating weight loss, especially in the waist area. I experienced no side effects with one capsule daily. Highly recommend!

Autoimmune Disorder details

Myo-inositol enhances vitamin D effects

Questionable

Based on 5 Researches

Krysiak R, Kowalcze K, Okopień B. The impact of vitamin D on thyroid autoimmunity and hypothalamic-pituitary-thyroid axis activity in myo-inositol-treated and myo-inositol-naïve women with autoimmune thyroiditis: A pilot study. J Clin Pharm Ther. 2022;47:1759. doi:10.1111/jcpt.13730

Our study aimed to explore the impact of myo-inositol treatment on thyroid autoimmunity in women with autoimmune thyroiditis. We included groups of women who had been on myo-inositol for a while and those who hadn’t. For six months, we observed how vitamin D supplementation interacted with myo-inositol in affecting thyroid health and immune responses.

We found that among participants taking myo-inositol, the addition of vitamin D significantly improved insulin sensitivity and led to better outcomes regarding thyroid antibodies. Specifically, women who were already on myo-inositol showed a greater reduction in thyroid peroxidase and thyroglobulin antibodies when vitamin D was added to their regimen.

Interestingly, the effects of vitamin D were less noticeable in women who weren't on myo-inositol. These individuals did not exhibit the same improvements in thyroid function or antibodies. Overall, the findings suggest that myo-inositol might enhance the benefits of vitamin D, indicating a potential synergistic effect between these two agents in managing autoimmune thyroiditis.

9.5

Significant improvement

Most Useful Review

I really liked this supplement! I ordered it for my mother, who is 59 years old and suffers from frequent headaches and noise in her head due to atherosclerosis. With this supplement, she has experienced a significant improvement; her sleep has improved, and she feels much more cheerful! I wish I had found this product sooner. My mother takes DMAE in the morning and Choline in the evening. I have already ordered a second jar.

Bone Pain details

Liver function improvement

This drug was prescribed to me to support my liver condition. I had pain in the right hypochondrium; despite normal tests, there were some liver changes. I appreciated the natural ingredients in this preparation. The capsules are a good size, neutral in taste, and easy to take. I felt the benefits—my pain has vanished, as has the heaviness and belching after meals. Overall, my liver function and digestion have improved, and my test results have stabilised.

Brain Tumor details

Conduit SE, Ramaswamy V, Remke M, Watkins DN, Wainwright BJ, et al. A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma. Oncogene. 2017;36:5969. doi:10.1038/onc.2017.208

INPP5E's impact on medulloblastoma

We examined how INPP5E influences Sonic Hedgehog (SHH) signaling in medulloblastoma, a common pediatric brain tumor. By using a murine model, we found that deleting INPP5E reduced tumor growth, cell proliferation, and SHH signaling while causing a loss of cilia on tumor cells.

Our findings suggest that INPP5E is crucial for maintaining primary cilia and promoting tumor progression. Interestingly, we observed that lower levels of INPP5E in human samples correlated with better survival outcomes, highlighting its potential as a therapeutic target in combating SHH medulloblastoma.

9.5

Reduced headaches

Most Useful Review

This supplement aids in the correct transmission of nerve impulses in the body. Choline and inositol are essential B vitamins necessary for brain, nervous system health, and fatty acid metabolism. I combine these with True Calm and have found noticeable relaxation, with almost no daily headaches. My mind remains clear until evening, which greatly enhances my concentration and overall performance.

Neuropathy details

Restores nerve damage

This product helps restore nerve damage. It's reversing the neuropathy damage in my feet from diabetes. An excellent product!

Sleep Apnea details

Sleep significantly improved

Excellent! After starting this supplement, I fall asleep quickly, enjoy a good night's rest, and no longer wake during the night. It appears to have positively impacted my hormonal system as well, enhancing my overall health.

Adhd details

I have ADHD and tend to get irritated over trivial matters, so I bought this after reading the reviews. Since I started drinking it, I've noticed that I am less irritated. I feel my ability to concentrate has increased, and it has become something I can't do without.

Autism details

My child has autism, speaks very little, and mostly communicates through gestures. After a month on this supplement, he began to speak a great deal, articulating poems and stories. I can hardly believe that such remarkable progress has stemmed solely from this dietary supplement. Why wasn't this suggested to us sooner?

Chronic Cough details

Eased breathing quickly

I have experienced stress-related coughing and breathing difficulties for some time, which recently worsened. This supplement has made my breathing easier and gradually diminished my cough. The capsules are large but manageable to swallow. I plan to continue taking it for a month to see further improvement.

Diabetes details

Myo-inositol aids gestational diabetes

Based on 10 Researches

Chen H, Xiong J, Li Z, Chen Y, Zhang M, et al. Influence of myo-inositol on metabolic status for gestational diabetes: a meta-analysis of randomized controlled trials. J Matern Fetal Neonatal Med. 2024;37:2228450. doi:10.1080/14767058.2023.2228450

We aimed to evaluate how myo-inositol supplementation affects women with gestational diabetes through a meta-analysis of randomized controlled trials. Our search included multiple databases, leading to the analysis of four studies involving 317 participants. The results showed that myo-inositol significantly reduced the need for insulin and improved insulin sensitivity. However, it did not influence birth weight, cesarean delivery rates, or NICU admissions. These findings suggest myo-inositol could be a helpful addition to managing gestational diabetes, but further research is needed.

8.8

Improved mood, diabetes relief

Most Useful Review

In combination with other supplements, I felt an improvement in my mood and energy. I managed to lose weight while addressing my liver fat, which is crucial for managing diabetes and insulin resistance. Siosis helped me discontinue antidepressants and is beneficial for diabetes.

Hair Loss details

Inositol synthesis and hair loss

Woolley DW. SYNTHESIS OF INOSITOL IN MICE. J Exp Med. 1942;75:277.

We explored whether inositol, when paired with pantothenic acid, impacts hair health in mice. The study revealed that mice can synthesize inositol, but this synthesis relies heavily on the presence of pantothenic acid in their diet. When pantothenic acid was absent, inositol production did not occur.

We noticed that cultures taken from the intestines of mice that naturally recovered from hair loss produced significantly higher levels of inositol. In contrast, similar cultures from hairless mice generated much less inositol. Additionally, we observed that inositol exists in both free and combined forms within various biological materials. Strikingly, we found that a deficit of inositol can arise even if inositol is dietary, provided pantothenic acid is missing.

Overall, though this research provides insights into inositol's synthesis and its connection with hair loss, it does not conclusively demonstrate that inositol alone effectively treats hair loss—particularly in the absence of pantothenic acid.

9.5

Improved hair regrowth

Most Useful Review

I use this to combat thinning hair. Choline, a vitamin-like substance, is vital for maintaining beauty and health. It prevents fatty liver, improves liver function, and crucially, stops hair loss. After three months of use, I noticed significantly less hair loss post-bathing, and fine hair is growing back. I've received compliments on the texture of my hair, indicating this supplement works well for me.

Insomnia details

This effective supplement supports the liver, and since I started taking it, my sleep has greatly improved. Without inositol, I’d struggle to sleep for hours. But with it, I fall asleep quickly and wake up refreshed. I highly recommend this for anyone with insomnia or related issues.

Irritable Bowel Syndrome details

Spagnuolo R, Cosco C, Mancina RM, Ruggiero G, Garieri P, et al. Beta-glucan, inositol and digestive enzymes improve quality of life of patients with inflammatory bowel disease and irritable bowel syndrome. Eur Rev Med Pharmacol Sci. 2017;21:102.

Supplement improves IBS symptoms

We explored how a mixture of beta-glucan, inositol, and digestive enzymes could alleviate gastrointestinal symptoms in patients with inflammatory bowel disease (IBD) and concurrent irritable bowel syndrome (IBS).

The study involved 43 patients who were already in clinical remission and treated only with mesalamine. They were divided into two groups: one received the usual treatment plus the supplement, while the other only received the standard care.

After four weeks, we observed notable improvements in symptoms such as bloating, flatulence, and abdominal pain in the group taking the supplement. Our findings suggest that this combination may significantly enhance the overall well-being of IBD-IBS patients, making their daily lives a bit easier.

9.5

Improved bowel movements

Most Useful Review

I discovered I had mild fatty liver during a work health check. After researching, I purchased this product. Choline aids nerve impulse conduction, liver function, and lecithin formation, helping to eliminate excess fat in the liver. Inositol can enhance gastrointestinal health; since taking it, my bowel movements have become smooth and regular, which has been excellent.

Knee Pain details

Prescribed by my doctor, I had a problem with my knee crackling. After a three-month course, the issue has vanished. I am very satisfied.

Polycystic Ovary Syndrome details

I purchased this for my ovarian cyst issue, and while it is pricier in my city, I found it at a reasonable price online. After two and a half months, my cyst hormones improved significantly. It serves as an effective alternative to Glucophage, minus the unpleasant side effects.

Stroke details

Inositol aids axon recovery

Kauer SD, Fink KL, Li EHF, Evans BP, Golan N, et al. Inositol Polyphosphate-5-Phosphatase K () Enhances Sprouting of Corticospinal Tract Axons after CNS Trauma. J Neurosci. 2022;42:2190. doi:10.1523/JNEUROSCI.0897-21.2022

We sought to understand how inositol polyphosphate-5-phosphatase K influences the recovery of axons in the context of stroke and other central nervous system (CNS) injuries. By studying intact corticospinal neurons from mice that had experienced a pyramidotomy, we found that this protein plays a crucial role in facilitating axon growth.

Our exploration involved various preclinical models and established that overexpressing inositol polyphosphate-5-phosphatase K in these neurons enhanced the sprouting of corticospinal tract terminals after a stroke, demonstrating promising effects not just after immediate injury but also in instances of chronic damage.

We observed that this enhancement occurs partly through the elevation of active cofilin within the growth cones of neurons, which catalyzes critical processes for maintaining healthy axon structures and supports the potential for neurological recovery post-stroke. The results indicate that inositol could be a significant factor in encouraging damaged CNS neurons to regrow axons, a key aspect of functional recovery following injuries like stroke or spinal cord trauma.

Ultimately, our findings reinforce the value of pursuing new strategies to boost axon growth in complex environments where traditional healing has been limited, showcasing the necessity of continued research into factors that promote nerve regeneration.

9.5

Supports recovery

Most Useful Review

It was instrumental in my father’s recovery following a stroke. He recovered satisfactorily from the effects of the stroke and the resulting physical weakness.

Atrial Septal Defect details

Improved play behaviour

For a child with ASD, neurons in the brain function like wires transmitting currents and consist of nerve cells wrapped in a sheath called myelin. This sheath prevents neurons from sparking against each other and directs impulses correctly. Myelin is composed of choline inositol, and children with ASD frequently experience impaired myelination due to neuroinflammation. Since incorporating this supplement into our regime, we've noticed immediate results. My child has begun to play appropriately with toys rather than scattering them and has shown a bit more calmness. I believe this supplement has certainly been beneficial, and I am pleased with its quality. The capsules are small and easily manageable; I mix them in a spoon, and the taste is neutral, so my child has no issues consuming it. If you liked this review, please give it a thumbs up—this helps us continue our journey to recovery. 🫶🏼

Cystic Fibrosis details

Ingredients effectiveness

It’s beneficial that choline and inositol can be taken together. Choline is known to improve memory and cognition, maintain heart health, boost fat metabolism, reduce pregnancy complications, and improve symptoms of Cystic Fibrosis. Inositol is believed to relieve anxiety, control blood glucose, and enhance conditions like polycystic ovary syndrome. I believe it's advantageous to combine both ingredients.

Depression details

Myo-inositol: Depression treatment potential

Based on 4 Researches

Derkaczew M, Martyniuk P, Osowski A, Wojtkiewicz J. Cyclitols: From Basic Understanding to Their Association with Neurodegeneration. Nutrients. 2023;15. doi:10.3390/nu15092029

We explored the potential of inositol, particularly Myo-inositol (MI), as a treatment option for depression, especially in individuals dealing with neurodegenerative disorders. The literature suggests that MI and its derivatives are vital in various cellular functions, including signal transmission and osmoregulation.

While our focus was primarily on neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's, the interesting twist is how inositol may also help alleviate depressive symptoms. Research indicates that dietary supplementation with MI can have promising effects on mental health, suggesting a connection between inositol levels and mood enhancement.

However, despite the encouraging findings, much remains to be discovered. The relationship between inositol treatment and its effectiveness in treating depression is still being closely examined. Overall, it appears that while inositol shows potential, more comprehensive studies are needed to fully understand its benefits and mechanisms related specifically to depression.

Healthy metabolism

Most Useful Review

B vitamins support brain health and fatty acid metabolism, reducing cholesterol levels. I've noticed a reduction in hair loss since taking this supplement, which has also proven effective for depression.

Heart Disease details

Inositol boosts heart protective adiponectin

Based on 3 Researches

Fu L, Du J, Furkert D, Shipton ML, Liu X, et al. Depleting inositol pyrophosphate 5-InsP7 protected the heart against ischaemia-reperfusion injury by elevating plasma adiponectin. Cardiovasc Res. 2024;120:954. doi:10.1093/cvr/cvae017

Our research focused on understanding how inositol, specifically a molecule called 5-InsP7, plays a role in heart health by influencing levels of a substance called adiponectin. Adiponectin is important because it helps protect against cardiovascular issues and metabolic disorders.

We discovered that the enzyme inositol hexakisphosphate kinase 1 (IP6K1) produces 5-InsP7, which helps regulate how much adiponectin is available in the bloodstream. This regulation occurs through a process that ensures adiponectin stays stable instead of degrading within the cells.

When we decreased the levels of 5-InsP7—either by knocking out the gene responsible for producing it or through specific drug treatments—we noticed a significant increase in adiponectin levels in the plasma. This increase particularly favored the high molecular weight forms of adiponectin, which are particularly beneficial for heart protection.

The findings suggest that targeting 5-InsP7 could be a promising strategy for enhancing adiponectin levels, potentially offering a new avenue for protecting the heart against damage from conditions like ischemia-reperfusion injury, which occurs when blood flow returns to the heart after a period of blockage.

Overall, this study gives insight into how inositol treatment might help heart disease, emphasizing the importance of adiponectin in cardiovascular health.

8.8

Husband feels better

Most Useful Review

My husband was advised by a doctor to take these supplements due to his stage 2 fatty liver disease. Following a course of treatment, he has reported feeling better, and his test results confirm this progress.

Hypothyroidism details

Choline aids offspring in hypothyroidism

Based on 13 Researches

Sheikhi S, Aghazadeh R, Sayyadi H, Pourheydar B, Saboory E, et al. The effects of choline supplementation in mothers with hypothyroidism on the alteration of cognitive-behavioral, long-term potentiation, morphology, and apoptosis in the hippocampus of pre-pubertal offspring rats. Int J Dev Neurosci. 2024;84:109. doi:10.1002/jdn.10312

We explored the impact of choline supplementation on the cognitive development of offspring from mothers with hypothyroidism. The study involved inducing hypothyroidism in mother rats during pregnancy and early postnatal life by adding a substance to their drinking water. To assess the potential benefits of choline, the mothers received this supplement via gavage from the start of pregnancy until their pups were 21 days old.

After administering the treatments, we tested the offspring’s cognitive abilities using methods like the Morris water maze, which measures spatial learning and memory. We also looked at long-term potentiation (LTP)—a key process related to learning—along with examining brain structures for any morphological changes or signs of cell death.

Our findings revealed that the hypothyroid condition negatively impacted both learning and memory, alongside reducing LTP. However, choline treatment appeared to reverse some of these deficits, enhancing the cognitive functions in the offspring.

While they showed improvements, it’s important to note that choline did not significantly reduce apoptosis in the hypothyroid group. Overall, our results suggest that choline can be beneficial in mitigating some cognitive impairments caused by maternal hypothyroidism, yet it does not address all the cellular challenges faced by the offspring.

9.5

Stopped hair loss

Most Useful Review

Stops with my hypothyroidism-related hair loss. With hypothyroidism, I often faced hair falling out. After six months on choline, inositol, and biotin, my hair has stopped falling out and is growing thickly again.

Menopause details

Cho KA, Kim YH, Woo SY, Ryu KH. Tonsil-Derived Mesenchymal Stem Cell-Derived Small Extracellular Vesicles (sEVs) Restore Myo-Inositol Production in LPS-Treated Skeletal Muscle. Tissue Eng Regen Med. 2025. doi:10.1007/s13770-025-00709-w

Based on 9 Researches

Myo-Inositol Support in Menopause

We investigated whether small extracellular vesicles (sEVs) derived from human palatine tonsil mesenchymal stem cells could boost myo-inositol levels in the context of menopause. This was particularly interesting given that menopausal women are prone to chronic inflammation due to physiological changes and related issues like metabolic syndrome.

To explore this, we treated mice with lipopolysaccharides (LPS) to simulate inflammation and assessed how the inclusion of T-MSC sEVs influenced myo-inositol production. After treatment, we measured levels of proteins involved in inositol synthesis in skeletal muscle and checked the serum for inositol levels.

Our findings are encouraging and suggest that T-MSC sEVs might help mitigate some effects of chronic inflammation linked to menopause. By supporting skeletal muscle mass and maintaining myo-inositol levels, these sEVs could be an effective strategy for improving metabolic health in menopausal women. This study sheds light on a potential new approach to tackle metabolic disturbances during this life stage.

9.5

Irritation reduced

Most Useful Review

I've repurchased this product as it has improved all symptoms of late-stage menopause for me. I even recommended it to my nephew, who experienced insomnia, and he felt better shortly after taking it. I truly appreciate inositol's effects and gladly recommend it for anyone looking to reduce irritability.

Multiple Sclerosis details

Gives vigour and strength! Since I began taking this choline with inositol, I immediately felt a surge of vitality, which I hadn't experienced for a long time due to multiple sclerosis. My mood improved significantly! It's a pity I didn't discover this sooner. Now, I plan to take it regularly in courses. Wishing everyone good health!

Tinnitus details

Very good drug; I order it for the whole family. The composition is beneficial for the nervous system, blood vessels, and hormonal levels. I also take it for my grandmother, as I read that it helps with tinnitus. The noise has become quieter; it hasn’t completely disappeared, but I will continue to take it in hopes of being completely free from it.

Flu details

Choline is crucial for liver health, brain development, muscle movement, and metabolism. I've taken it daily for almost a year as part of my liver cleanse post-fatty liver. The results have been fantastic. Since I can’t consume enough eggs, this supplement is a great find. The addition of inositol is beneficial as it influences insulin action and brain chemical messengers. I appreciate NOW for their high-quality, affordable products.

Leg Cramps details

After taking this, my menstrual cramps were noticeably milder, and I didn't need painkillers this time. I started with it for PMS relief and, along with gamma-linolenic acid, I found it preferable to taking nothing. The capsule size is quite large, but I have adapted as I regularly use other NOW products. It worked so well that I plan to repurchase it once I run out.

Obesity details

Inositol's role in diet-induced obesity

Based on 12 Researches

Stilgenbauer L, Chen Q, Pungi D, James N, Jayarathne H, et al. Microglial ER stress response via IRE1α regulates diet-induced metabolic imbalance and obesity in mice. Mol Metab. 2025;95:102128. doi:10.1016/j.molmet.2025.102128

We examined the impact of a key sensor of endoplasmic reticulum stress, IRE1α, on obesity related to high-fat diets. By removing IRE1α specifically in microglial cells in male mice, we noticed a significant decrease in inflammation and metabolic dysfunction associated with diet-induced obesity. The results revealed that deleting IRE1α helped protect these male mice from weight gain and glucose intolerance. However, similar benefits were not found in female mice, indicating a gender-specific response to IRE1α deletion.

Improves stress resilience

Most Useful Review

Choline and inositol, belonging to the B vitamin group, significantly influence brain and nervous system health. Choline (vitamin B4) supports cognitive function, helps manage stress, and prevents depression. It promotes sleep quality and regulates glucose levels to avert diabetes. Additionally, choline boosts metabolism and liver function, aiding in obesity prevention. Inositol (vitamin B8) enhances brain performance and counters fatigue, helping maintain proper metabolism while benefitting skin health as well.

Pelvic Pain details

Prominent! I felt that the pain from a cyst eased significantly in the first month of usage, God willing, and I hope to resolve it completely in two months.

Alzheimer details

D-Pinitol shows promise in Alzheimer's

Medina-Vera D, López-Gambero AJ, Verheul-Campos J, Navarro JA, Morelli L, et al. Therapeutic Efficacy of the Inositol D-Pinitol as a Multi-Faceted Disease Modifier in the 5×FAD Humanized Mouse Model of Alzheimer's Amyloidosis. Nutrients. 2024;16. doi:10.3390/nu16234186

We explored the potential of D-Pinitol (DPIN), a compound derived from carob pods, as a game-changing treatment for Alzheimer's disease (AD). With AD being a leading cause of dementia and lacking effective long-term solutions, we sought to evaluate how DPIN could alter the course of this debilitating condition.

Our research focused on the 5×FAD mouse model, which closely mimics the Alzheimer-like symptoms in humans. Through chronic oral administration of DPIN at a dosage of 200 mg/kg/day, we observed various promising effects. Notably, DPIN improved cognitive performance in the mice, reduced harmful amyloid beta and tau protein levels, and even enhanced the expression of insulin-degrading enzymes that could help regulate insulin in the system.

Additionally, DPIN seemed to support gut health, countering chronic inflammation and restoring the balance of gut microbiota. This is significant because gut issues are increasingly recognized as a contributing factor to Alzheimer's. The compound not only helped repair intestinal barriers but also reduced inflammation markers associated with a leaky gut.

Overall, these findings suggest that D-Pinitol could serve as a multifaceted approach to modify the progression of Alzheimer's in its early stages, potentially shifting the landscape of how we treat this serious condition.

9.5

Combats memory loss

Most Useful Review

Choline is crucial for human growth, development, and various bodily functions. Highest in dairy and meat, it assists nerve cells in communication. Recent studies suggest choline may combat Alzheimer's disease and improve memory. It also maintains cell structure and liver health, vital for a healthy nervous system and brain development.

Cycle stability achieved

Inositol has been a fantastic supplement for restoring my menstrual cycle and ovulation. My cycle is now stable at 28-30 days, and I’ve noticed significant improvements in my skin as my acne has disappeared. I highly recommend it!

Cardiovascular Disease details

Inositol protects against cardiac damage

L'Abbate S, Nicolini G, Forini F, Lepore E, Marchetti S, et al. Oral supplementation of inositols effectively recovered lithium-induced cardiac dysfunctions in mice. Biomed Pharmacother. 2024;178:117287. doi:10.1016/j.biopha.2024.117287

We investigated how inositol supplementation could counteract heart issues caused by lithium in mice. Our study involved four groups of mice to explore the varying effects of inositol. One group received lithium alone, another received lithium followed by inositol, a third group had both lithium and inositol from the start, and a control group had no treatment at all.

The results were promising. We found that inositol had a protective effect against the heart damage typically associated with lithium. Specifically, it helped improve heart function and reduced susceptibility to arrhythmias—irregular heartbeats. We also noted that inositol seemed to restore healthy levels of certain proteins crucial for heart health, helping to reduce cell enlargement and stress associated with hypertrophy.

Interestingly, the benefits of inositol were evident regardless of whether it was given alongside lithium or afterward as a treatment. These findings suggest that inositol could be a valuable addition to therapy for those facing lithium-induced cardiac issues, offering a potential pathway to better heart health.

9.5

Fatty liver control

Most Useful Review

I've used this product for 10 years after being diagnosed with fatty liver. Despite not changing my lifestyle, regular testing has shown normal liver function. Choline and inositol significantly help reduce fatty deposits, promoting liver health.

High Cholesterol details

Okazaki Y, Katayama T. Dietary inositol hexakisphosphate, but not myo-inositol, clearly improves hypercholesterolemia in rats fed casein-type amino acid mixtures and 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane. Nutr Res. 2008;28:714. doi:10.1016/j.nutres.2008.07.003

Based on 10 Researches

IP6 improves cholesterol levels

We examined the effects of inositol hexakisphosphate (IP6) and myo-inositol on high cholesterol in rats. In our study, we found that dietary IP6 effectively reduced increased cholesterol levels caused by a specific chemical exposure, while myo-inositol did not show significant benefits.

Additionally, IP6 also contributed to body weight gain, regardless of other dietary factors. Overall, while both inositol types helped prevent fatty liver, only IP6 demonstrated a clear advantage in managing hypercholesterolemia.

9.5

Effective cholesterol reduction

Most Useful Review

The supplement helped me lower my cholesterol. I took 2 capsules daily, and within a month and a half, my cholesterol dropped from 230 to 170.

Arteriosclerosis details

Inositol extract curbs atherosclerosis inflammation

Based on 4 Researches

Lee J, Park J, Song KM, Lee YG, Choi HK. Extract Containing -Inositol Suppresses TNF--Induced VCAM-1 Expression and Monocyte Adhesion to Endothelial Cells via Inhibition of the PTEN/Akt/GSK-3 and NF-B Signaling Pathways. J Med Food. 2024;27:419. doi:10.1089/jmf.2023.K.0326

We investigated how inositol, a key component found in an edible fruit extract, affects the early stages of arteriosclerosis—specifically, monocyte adhesion to endothelial cells, which is crucial in the development of cardiovascular diseases. Using human umbilical vein endothelial cells stimulated with tumor necrosis factor (TNF), we discovered that the inositol-rich extract substantially reduced the expression of vascular cell adhesion molecule-1 (VCAM-1). This reduction is important because VCAM-1 is a protein that facilitates monocyte attachment to blood vessel walls.

Our findings revealed that, through complex signaling pathways, the extract upregulated a protein called phosphatase and tensin homolog (PTEN). This process helped inhibit the activation of AKT and glycogen synthase kinase 3 (GSK-3), which are involved in inflammatory responses. Interestingly, we also saw that the extract interfered with the activation of the nuclear factor kappa B (NF-κB) pathway, further decreasing the expression of various pro-inflammatory genes.

In animal studies, the oral administration of this extract notably decreased VCAM-1 expression and monocyte infiltration in mouse models of arteriosclerosis. These compelling results point to the potential of using inositol as a nutraceutical aimed at preventing the onset of arteriosclerosis by addressing its initial inflammatory processes.

6.8

Weight loss aid

Most Useful Review

As expected, my cholesterol levels had risen, and I was diagnosed with hyperlipidaemia for several years. However, my doctor was serious about preventing arteriosclerosis, and after four months, I lost 10kg. I realised that I also needed supplements, so I searched for anti-bite options and found one that looked good. After taking it, I felt it was beneficial for me. At night, it calmed my spirit and allowed me to sleep peacefully. I usually don’t cope well with stress. The autonomic nerve feels broken, and alongside taking DHA, I believe choline and inositol will be my saviours. The product is remarkably effective and balances my mental and physical state. I even prepare it as a refreshing drink like lemon water.

Blood Clot details

SCI offers safe anticoagulant potential

Likely Very Effective

Al-Horani RA, Abdelfadiel EI, Afosah DK, Morla S, Sistla JC, et al. A synthetic heparin mimetic that allosterically inhibits factor XIa and reduces thrombosis in vivo without enhanced risk of bleeding. J Thromb Haemost. 2019;17:2110. doi:10.1111/jth.14606

We explored the effects of a synthetic heparin mimetic known as sulfated chiro-inositol (SCI) on blood clotting mechanisms. This innovative treatment aims to inhibit human factor XIa (FXIa), a key player in the clotting process, while minimizing bleeding risks typically associated with anticoagulants.

In our study, we synthesized SCI to engage FXIa specifically by targeting its heparin-binding sites. Through various blood coagulation assays and in vivo models, we observed that SCI effectively inhibited FXIa, leading to reduced clot formation without significant safety concerns. In particular, SCI demonstrated potent anticoagulant properties, matching the performance of existing treatments like enoxaparin but at a much lower dosage.

Importantly, our investigations revealed that SCI's effects could be reversed by common antidotes, which adds an important layer of safety. While we noted no major bleeding risks or toxicity in the studies, further research is needed to ensure SCI's efficacy across broader clinical scenarios. Overall, our findings highlight SCI as a promising candidate for safer anticoagulation therapies.

9.5

Liver function support

Most Useful Review

I've used this product for ten years following a scan revealing fatty layers in my liver, an early indication of severe liver disease. After extensive research, I discovered that choline bitartrate and inositol both help diminish fatty liver deposits. I continued taking them while maintaining my regular lifestyle, and subsequent tests have shown excellent liver health.

Constipation details

BZYQD enhances motility and reduces inflammation

Ju WJ, Zhao ZK, Chen SL, Zhou DD, Yang WN, et al. Buzhongyiqi Decoction Protects Against Loperamide-Induced Constipation by Regulating the Arachidonic Acid Pathway in Rats. Front Pharmacol. 2020;11:423. doi:10.3389/fphar.2020.00423

We aimed to understand the effects of Buzhongyiqi decoction (BZYQD) on constipation, particularly how it influences various metabolic pathways. In our exploration, we conducted experiments on rats experiencing loperamide-induced constipation. Following treatment with BZYQD, we observed a notable increase in the small intestinal transit rate, suggesting improved digestive movement.

Our findings also revealed that BZYQD helped to reduce pathological damage in the colon. Interestingly, one of the key factors we looked at was inositol, a metabolite whose levels were significantly affected by the treatment. We discovered that BZYQD not only increased serum levels of inositol but also enhanced the levels of motilin and gastrin, hormones that play important roles in regulating gastrointestinal motility.

Additionally, our analysis showed that BZYQD impacted inflammatory pathways by reducing the production of pro-inflammatory mediators and down-regulating markers like cyclooxygenase-2. These effects suggest a comprehensive approach to managing constipation might involve multiple metabolic pathways, with inositol being a notable component. Overall, our study suggests that BZYQD can protect against constipation, with inositol contributing to this beneficial effect, though further studies are needed to isolate its specific impact.

8.8

Bowels regulated

Most Useful Review

I tested it on myself and my mother. This is not my first time using it. I noticed that it helps to establish bowel movements and eliminates constipation. However, it's challenging to isolate the rest of the effects since we take various supplements. Gradually, I’ve noticed my weight decreasing.

Heart Attack details

ITPP enhances heart attack recovery

Likely Very Effective

Oknińska M, El-Hafny-Rahbi B, Paterek A, Mackiewicz U, Crola-Da Silva C, et al. Treatment of hypoxia-dependent cardiovascular diseases by myo-inositol trispyrophosphate (ITPP)-enhancement of oxygen delivery by red blood cells. J Cell Mol Med. 2020;24:2272. doi:10.1111/jcmm.14909

We explored the potential of myo-inositol trispyrophosphate (ITPP) as a treatment for heart attacks and its effect on heart tissue injured by low oxygen levels. This research indicates ITPP modifies hemoglobin in red blood cells, enhancing the delivery of oxygen throughout the body.

Using an animal model for myocardial infarction, we observed that ITPP administration provided significant protection against heart failure and aided in recovery from left ventricular remodeling following the heart attack.

In our laboratory studies, heart muscle cells exposed to low oxygen levels reacted quickly to ITPP treatment, showing increased activity of a protein known as HIF-1. Interestingly, this overactivity was countered by ITPP when it was in the red blood cells, which suggests a strong connection between shear stress from blood flow and oxygen release facilitated by the modified hemoglobin.

Overall, the findings indicate that ITPP could be a game-changer in treating injuries to heart tissues related to low oxygen or ischemia. This approach may open new avenues for effectively managing damage caused by heart attacks.

9.5

Calm heart rate

Most Useful Review

Cospa is fantastic. I found that the frustrating hurdles were diminishing year by year, prompting me to try it. I was astonished at its effectiveness for such a low-cost supplement; it made my heart markedly calmer. Initially, I thought I was entering menopause due to my age, but this was more effective than any other products I'd tried.

Swollen Lymph Nodes details

An excellent medication; after taking it, I felt a surge of energy and vitality, and I lost a bit of weight as well as my swelling. The tablets are small and easy to swallow. Overall, I urge everyone to leave a like if they don’t mind.

Acne details

Myo-inositol improves acne symptoms

Based on 8 Researches

Zacchè MM, Caputo L, Filippis S, Zacchè G, Dindelli M, et al. Efficacy of myo-inositol in the treatment of cutaneous disorders in young women with polycystic ovary syndrome. Gynecol Endocrinol. 2009;25:508. doi:10.1080/09513590903015544

We explored the effects of myo-inositol (MYO) on acne among young women diagnosed with polycystic ovary syndrome (PCOS). The study included 50 participants who underwent treatment with MYO for six months, focusing on its potential to improve the often frustrating skin issues linked to PCOS.

At the beginning and after the treatment period, we measured various factors including levels of hormones and insulin, as well as the severity of acne.

Remarkably, after three months of MYO therapy, we observed significant reductions in hormone levels associated with PCOS, particularly testosterone and insulin. After six months, both hirsutism and acne symptoms showed notable improvement among the participants.

This research highlights MYO as a promising, safe treatment option for alleviating acne symptoms in individuals with PCOS. Its ability to improve metabolic conditions while managing acne is a fascinating development for women seeking effective solutions for their skin concerns.

9.5

Period regularity

Most Useful Review

For those suffering from polycystic ovaries, I highly recommend this treatment. After two months, my periods returned, chronic pain disappeared, and my acne has improved significantly. Using a higher dosage is more effective; I take two to three tablets daily.

Adenoiditis details

Effective throat relief

I purchased these lozenges for myself and have found them effective. Previously, I used picolinate, but chose lozenges this time and I'm pleased with that decision. They have a pleasant taste and soothe the throat while dissolving. Unlike some pharmaceutical preparations that made me feel nauseous after taking zinc, I experienced none of that with these lozenges. If you're concerned about nausea, try taking it with food. I’ve noticed a positive effect, particularly when starting to feel a sore throat, as I take it every 2 hours as instructed, significantly alleviating discomfort. I recommend them!

Parkinson details

VCE-006.1 shows promise in Parkinson's

Burgaz S, García C, Gonzalo-Consuegra C, Gómez-Almería M, Ruiz-Pino F, et al. Preclinical Investigation in Neuroprotective Effects of the GPR55 Ligand VCE-006.1 in Experimental Models of Parkinson's Disease and Amyotrophic Lateral Sclerosis. Molecules. 2021;26. doi:10.3390/molecules26247643

We examined the neuroprotective effects of VCE-006.1, a compound targeting the GPR55 receptor, using murine models of Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS).

Our results showed that VCE-006.1 successfully reversed motor impairments and some neurodegeneration caused by toxins in PD models. However, there were no significant benefits observed in ALS models regarding neurological decline.

Overall, while VCE-006.1 demonstrated potential neuroprotection in Parkinson’s, it was ineffective in ALS, indicating the need for tailored cannabinoid therapies for different neurodegenerative diseases.

9.5

Preserves memory

Most Useful Review

Choline enhances nerve impulse transmission, making it effective for treating nervous system disorders like Parkinson's. It boosts brain activity and supports clear memory into old age.

Migraine details

Reduced migraine frequency

The neurologist prescribed medication for increased intracranial pressure for my adult son. In our pharmacy, tablets for 28 days cost 1400 rubles. I later found an analogue on iHerb, obtaining pills for three months for 500 rubles. I'm delighted! This excellent medication significantly reduces the frequency of my migraine attacks and seems particularly effective for those suffering from increased intracranial pressure.

Nausea details

Good. The second jar has shown results. The nausea and burning in my left side have gone, and I'm very satisfied.

Rash details

Due to postpartum obesity, I started using healthy ketone on August 15. Shortly after, I developed keto rash symptoms, but after two weeks, the rash on my chest began to fade significantly. The ingredients, including choline and inositol, also boost brain health and aid in hair and nail growth.

Cancer details