Supplement Facts
Serving Size: 1 Nugget
Amount Per Serving
%DV
Vitamin B12 (as methylcobalamin)
5,000 mcg
208,333%
The product is found useful for the following medical conditions
Anemia details
SCIENTIFIC SCORE
Moderately Effective
Based on 21 Researches
8.2
USERS' SCORE
Excellent
Based on 8 Reviews
9
9.5
We explored the case of a 23-month-old boy suffering from severe pancytopenia linked to Imerslund-Gräsbeck syndrome, a rare condition caused by an inability to absorb vitamin B12. Upon diagnosis, the boy received vitamin B12 replacement therapy, which effectively addressed his symptoms and improved his health.
This case highlights the significance of early detection and treatment of IGS to avoid potential neurological damage. It's crucial to recognize this condition, even when neurological symptoms are absent, to provide timely care.
This case highlights the significance of early detection and treatment of IGS to avoid potential neurological damage. It's crucial to recognize this condition, even when neurological symptoms are absent, to provide timely care.
10
Life-saving solution
Most Useful Review
152 people found this helpful
This product saved my life due to Pernicious Anemia. I experienced severe symptoms which worsened over time. I self-diagnosed after recalling symptoms of Vitamin B12 deficiency. After starting this product, my symptoms improved significantly, and I truly believe it helped me stay alive.
Updated: Apr 2025
Leg Cramps details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.6
10
Severe cramps prevented
Most Useful Review
1 people found this helpful
This is a lifesaver for preventing my severe leg cramps. Having suffered from them since childhood, I realised I needed more magnesium. This chelated magnesium works without causing loose bowels, and if I miss a dose, cramps return but the magnesium quickly alleviates them.
Updated: Apr 2025
Anxiety details
SCIENTIFIC SCORE
Questionable
Based on 12 Researches
6.4
USERS' SCORE
Good
Based on 4 Reviews
8.5
8
We investigated the potential of vitamin B12 to mitigate anxiety in adult zebrafish subjected to chronic alcohol exposure. Our study involved exposing zebrafish to alcohol and then providing them with vitamin B12 to see if it would help reduce anxiety-related behaviors. By using a geotaxis test, we could observe how the fish responded in terms of anxiety in a controlled environment.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
10
Severe anxiety resolved
Most Useful Review
10 people found this helpful
Great for sleep and mental health! I had a severe B12 deficiency impacting my mental health, including extreme anxiety and insomnia. My symptoms completely vanished after over 16 shots of 1000mg B12. My levels are now ideal, and I feel energised, sleep well, and my anxiety has dissipated. I trust Solgar for maintaining my optimal levels.
Updated: Apr 2025
Blood Clot details
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.9
USERS' SCORE
Good
Based on 8 Reviews
8.5
8
We examined a case involving a 56-year-old male who suffered from severe vitamin B12 deficiency. This deficiency led to dangerously high homocysteine levels, which are associated with blood clot formation. Despite effective treatment with B12, this case illustrates that vitamin deficiency can lead to significant health issues, including thrombosis and embolism.
The patient’s condition improved with B12 injections, but the interplay between low vitamin levels and clotting risks was evident. It’s clear that while vitamin B12 treatment can help, avoiding complications like blood clots remains crucial.
The patient’s condition improved with B12 injections, but the interplay between low vitamin levels and clotting risks was evident. It’s clear that while vitamin B12 treatment can help, avoiding complications like blood clots remains crucial.
9
Rapid B12 increase
Most Useful Review
4 people found this helpful
A very quick method to elevate B12 levels in the blood!
Updated: Mar 2026
Dizziness details
SCIENTIFIC SCORE
Moderately Effective
Based on 17 Researches
8.4
USERS' SCORE
Good
Based on 6 Reviews
8.5
9.5
We examined a unique case involving a 28-year-old male who experienced dizziness related to severe anemia from low vitamin B12 levels.
After treatment with daily vitamin B12 injections, his symptoms and lab values significantly improved, indicating a positive response to the treatment.
Despite the rare nature of his condition—seronegative pernicious anemia—the results suggest that B12 can effectively alleviate dizziness stemming from anemia in similar cases.
After treatment with daily vitamin B12 injections, his symptoms and lab values significantly improved, indicating a positive response to the treatment.
Despite the rare nature of his condition—seronegative pernicious anemia—the results suggest that B12 can effectively alleviate dizziness stemming from anemia in similar cases.
9
Prevents dizziness
Most Useful Review
3 people found this helpful
Great sublingual vitamin B12. I've used this product for over a year, and it has helped tremendously in preventing dizziness due to B12 absorption issues from Crohn's surgery! Sublingual is an excellent method for B12 intake.
Updated: Apr 2025
Neuropathy details
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.5
USERS' SCORE
Good
Based on 3 Reviews
8.5
8
We explored the effects of vitamin B12 deficiency on neurological health in elderly patients. In a case study involving two patients, we observed that even with normal B12 levels, symptoms like fatigue and cognitive impairment persisted, especially in those with significant medical histories.
Treatment with hydroxocobalamin injections led to notable improvements in both patients’ cognitive and motor functions. This highlights the importance of recognizing vitamin B12 deficiency in older adults, even when traditional tests suggest adequate levels.
Treatment with hydroxocobalamin injections led to notable improvements in both patients’ cognitive and motor functions. This highlights the importance of recognizing vitamin B12 deficiency in older adults, even when traditional tests suggest adequate levels.
9
Effective assistance provided
Most Useful Review
4 people found this helpful
This definitely helps with neuropathy! It can be slightly overstimulating, so I recommend taking it before noon. I split the tablets in half, taking one before breakfast and the other before lunch, allowing them to dissolve under my tongue.
Updated: Apr 2025
Athlete’s Foot details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.4
9
Tingling reduction
Most Useful Review
1 people found this helpful
Wonderful. The tingling in my feet and hands has noticeably diminished.
Updated: Apr 2025
Autoimmune Disorder details
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.6
USERS' SCORE
Good
Based on 7 Reviews
8.4
9
We examined a case of a 51-year-old Ugandan man who experienced recurring lower limb weakness linked to pernicious anemia, an autoimmune condition causing vitamin B12 deficiency. After initial treatments, his symptoms reappeared, leading to further testing that confirmed the diagnosis.
Treatment with vitamin B12 injections significantly improved his condition. This case emphasizes the need for healthcare providers to recognize the signs of vitamin B12 deficiency early, particularly in resource-limited settings, to ensure timely diagnosis and treatment.
Treatment with vitamin B12 injections significantly improved his condition. This case emphasizes the need for healthcare providers to recognize the signs of vitamin B12 deficiency early, particularly in resource-limited settings, to ensure timely diagnosis and treatment.
10
Highly effective B12
Most Useful Review
3 people found this helpful
Only thing that actually works. I had really low B12 levels (around 190) and had been taking other 1000mg cyanocobalamin tablets before breakfast daily for months. Despite this, my low levels persisted, so my doctor prescribed me 1000mg cyanocobalamin injections weekly for two months. However, my levels remained unchanged. Desperate, I decided to try these tablets, and they are genuinely the only thing that has worked for me. They keep my B12 levels high and taste great! I highly recommend these to anyone - nothing else works as effectively, even compared to injections!
Updated: Apr 2025
Cardiovascular Disease details
SCIENTIFIC SCORE
Questionable
Based on 9 Researches
6.7
USERS' SCORE
Good
Based on 3 Reviews
8.4
8
We examined the role of vitamin B status on mortality rates, focusing on cardiovascular disease. Using data from over 12,000 adults, we found that higher scores on the combined vitamin B status indicator (3cB) were linked to lower risks of dying from cardiovascular issues. Specifically, individuals with lower 3cB scores faced significantly higher risks of mortality. This suggests that maintaining adequate vitamin B levels could potentially play an important part in reducing cardiovascular disease-related deaths.
9
Higher B12 levels
Most Useful Review
2 people found this helpful
Excellent! These Solgar methylcobalamin pills really work, as confirmed by a blood test! I love them and also gave them to my husband, who has Crohn's Disease. Previously reliant on B12 injections, his blood tests now show he no longer needs them after taking these pills sublingually. This clearly demonstrates their efficacy in increasing B12 levels in the body!
Updated: Apr 2025
Diabetes details
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.9
USERS' SCORE
Good
Based on 3 Reviews
8.4
8
We explored a novel oral delivery system using vitamin B12, fucoidan, and concanavalin A to enhance insulin effectiveness for diabetes management. This smart nanosystem targets inflammation while regulating blood glucose levels efficiently. Our findings indicated that when tested on type I diabetic mice, the nanosystem significantly lowered blood sugar and reduced inflammatory markers, such as TNF-α and interleukin-6. Notably, the system ensures safe and effective delivery, presenting a promising alternative to traditional insulin methods.
7.5
Recommended for diabetes
Most Useful Review
2 people found this helpful
Excellent! This product is truly marvellous for nerve issues. This is the third time I have ordered it for my mother, who sometimes experiences numbness in her fingers, and for my father, who suffers from type 1 diabetes. I highly recommend it.
Updated: Apr 2025
Food Poisoning details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 3 Reviews
8.4
7
We explored how vitamin B12 might serve as a protective agent against food poisoning, particularly from pyrrolizidine alkaloids found in tansy ragwort. The study assessed various dietary supplements alongside vitamin B12, including butylated hydroxyanisole and cysteine, on rats exposed to these toxic compounds. While the combination of these agents did enhance the survival time of the rats significantly, the added vitamin B12 did not show any notable improvement in outcomes when used alone.
In examining our findings, it became clear that B12's contribution in isolation lacked evidence of effectiveness against PA poisoning. The results indicated that while certain combinations could be beneficial, vitamin B12 alone did not alter the susceptibility to the toxic effects observed from the chronic consumption of tansy ragwort. This highlights the need for further investigation into the role of B12 and how it interacts with other treatments.
In examining our findings, it became clear that B12's contribution in isolation lacked evidence of effectiveness against PA poisoning. The results indicated that while certain combinations could be beneficial, vitamin B12 alone did not alter the susceptibility to the toxic effects observed from the chronic consumption of tansy ragwort. This highlights the need for further investigation into the role of B12 and how it interacts with other treatments.
9
Symptoms disappeared
Most Useful Review
1 people found this helpful
Best B12 for vegans and raw foodists! After switching to a vegan diet, I had a strong shortage of B12. Remarkably, after taking just one pill, the deficiency symptoms disappeared. My B12 levels are now back to normal, and I take 5000 units once a week under the tongue. I highly recommend this to everyone.
Updated: Apr 2025
High Cholesterol details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.5
USERS' SCORE
Good
Based on 4 Reviews
8.4
9
We focused on whether white button mushrooms could help lower cholesterol levels and blood sugar in rats. In our study, we found that after three weeks of the mushroom powder, diabetic rats showed significant drops in glucose and triglyceride levels.
Furthermore, in hypercholesterolemic rats, a four-week treatment led to impressive reductions in total cholesterol and LDL cholesterol. Overall, these findings suggest that white button mushrooms may have beneficial effects on cholesterol and blood sugar management, at least in rat models.
Furthermore, in hypercholesterolemic rats, a four-week treatment led to impressive reductions in total cholesterol and LDL cholesterol. Overall, these findings suggest that white button mushrooms may have beneficial effects on cholesterol and blood sugar management, at least in rat models.
9
Highly effective B12
Most Useful Review
8 people found this helpful
Excellent digestible B12! I highly recommend it! My B12 rose from 170 to 470 in just one month, alongside methylfolate 400mcg.
Updated: Apr 2025
Back Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 17 Researches
8.3
USERS' SCORE
Good
Based on 2 Reviews
8.3
9
We evaluated the effectiveness of intramuscular vitamin B12 in treating low back pain among 60 patients aged 18 to 65 with mechanical pain lasting at least six months.
In this double-blind, placebo-controlled study, both groups showed improvement in pain levels. However, those receiving B12 had a more significant reduction in pain and dependence on pain medication compared to the placebo group.
Overall, B12 appears to be a safe option for alleviating low back pain, helping to reduce discomfort and medication use for those without nutritional deficiencies.
In this double-blind, placebo-controlled study, both groups showed improvement in pain levels. However, those receiving B12 had a more significant reduction in pain and dependence on pain medication compared to the placebo group.
Overall, B12 appears to be a safe option for alleviating low back pain, helping to reduce discomfort and medication use for those without nutritional deficiencies.
7.5
Increased clarity
Most Useful Review
66 people found this helpful
Sublingual Gold! Wow! There is a significant difference from my previous B12 supplement, Cyanocobalamin. I've experienced numerous benefits in a short period, notably less fatigue, more restful sleep, considerably reduced back and joint pain, and clearer thinking. Given these positive effects, it seems my B12 levels had been almost nonexistent due to years of PPIs, and Cyanocobalamin just wasn't sufficient.
Updated: Mar 2026
Brain Tumor details
SCIENTIFIC SCORE
Likely Ineffective
Based on 1 Research
4
USERS' SCORE
Good
Based on 7 Reviews
8.3
4
Vitamin B12's unclear impact on glioblastoma
We explored the effects of vitamin B12 (cobalamin) supplementation on a human glioblastoma cell line known as U-87 MG. Our main goal was to understand how cobalamin, particularly in combination with pyridoxine (vitamin B6), influences cell viability and the process of cell death, known as apoptosis.
Our approach involved treating the glioblastoma cells with varying concentrations of vitamin B12 over a period of 24 to 72 hours. We assessed the health of the cells and their progression through the cell cycle using methods like spectrophotometry and flow cytometry. We also measured specific proteins associated with cell survival and death through western blot analysis.
We found that while vitamin B6 supplementation led to decreased cell viability and increased signs of apoptosis, the role of vitamin B12 was less clear. It appeared that cobalamin did not significantly enhance or inhibit cell death on its own. However, when combined with pyridoxine, it seemed to reduce the cytotoxic effects of vitamin B6.
In summary, while vitamin B12 in isolation did not show a direct benefit for the glioblastoma cells in our study, its potential to influence the effects of other vitamins highlights a complex interaction deserving of further exploration.
Our approach involved treating the glioblastoma cells with varying concentrations of vitamin B12 over a period of 24 to 72 hours. We assessed the health of the cells and their progression through the cell cycle using methods like spectrophotometry and flow cytometry. We also measured specific proteins associated with cell survival and death through western blot analysis.
We found that while vitamin B6 supplementation led to decreased cell viability and increased signs of apoptosis, the role of vitamin B12 was less clear. It appeared that cobalamin did not significantly enhance or inhibit cell death on its own. However, when combined with pyridoxine, it seemed to reduce the cytotoxic effects of vitamin B6.
In summary, while vitamin B12 in isolation did not show a direct benefit for the glioblastoma cells in our study, its potential to influence the effects of other vitamins highlights a complex interaction deserving of further exploration.
9
Clarity and energy
Most Useful Review
Excellent. The best brand I have tried. This is the most effective brand thus far. I have tried numerous brands that simply do not work. This and Jarrow work exceptionally well, but this one truly stands out. It provides clarity and instant energy for my mind. Remarkable for overcoming physical and mental fatigue as well as brain fog. Although I am not keen on the inclusion of mannitol, I can overlook that.
Updated: Apr 2025
Mild Cognitive Impairment details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.3
9
Energised mother
Most Useful Review
Excellent product. My mother suffers from Mild Cognitive Impairment; however, this product has had a positive effect on her. She has become more energised, and the quality of the vitamin B12 seems very good.
Updated: Apr 2025
Pelvic Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 6 Reviews
8.3
9
Helps with pain
Most Useful Review
4 people found this helpful
Great for Trigeminal Neuralgia! I take this product, and it definitely helps to keep the pain at bay.
Updated: Apr 2025
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.4
USERS' SCORE
Good
Based on 7 Reviews
8.2
0
Vitamin B12 ineffective for CFS
We explored the effectiveness of high-dose vitamin B12 injections on chronic fatigue syndrome (CFS) through two case reports that utilized N of 1 trials. This approach allowed us to make tailored treatment decisions based on individual responses to the therapy.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
9
Changed my life
Most Useful Review
1 people found this helpful
This product is fantastic. After trying various chewable Methylcobalamin, I chose this one, and I'm glad I did. It tastes lovely and energises me. I no longer feel fatigued or prone to illness. It has genuinely changed my life, and I highly recommend it!
Updated: Apr 2025
Insomnia details
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.7
USERS' SCORE
Good
Based on 3 Reviews
8.2
8
Vitamin B12 promotes sleep in rats
We sought to determine the impact of vitamin B12 (VB12) on sleep patterns in rats, particularly considering its potential benefits for those struggling with insomnia. By giving rats a daily intravenous dose of VB12, we monitored their sleep using polysomnographic recordings over a four-day period.
During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.
Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.
During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.
Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.
9
Improved mental health
Most Useful Review
10 people found this helpful
Great for sleep and mental health. I had a severe B12 deficiency that significantly impacted my mental health. No doctor ruled it out until my mother suggested I check my blood serum level. My severe insomnia, extreme anxiety, and OCD completely disappeared after more than 16 shots of B12 1000mg methylcobalamin. My levels are now ideal at over 500 for good mental and nerve health. I feel energised, sleep well, and my anxiety has vanished. I take Solgar B12 three times a week to maintain this essential vitamin level. Solgar is a trustworthy brand; their supplement has worked well for me as I regularly monitor my blood levels.
Updated: Apr 2025
Sleep Apnea details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.9
9
Consistent improvement
Most Useful Review
Excellent product and outstanding service. I have purchased this for many years, and it most certainly improves my sleep. I take it primarily for neuropathy.
Updated: Apr 2025
Depression details
SCIENTIFIC SCORE
Questionable
Based on 21 Researches
6.9
USERS' SCORE
Moderately Good
Based on 5 Reviews
7.7
8
We explored the connection between vitamin B levels and depression in older adults over four years. Our study followed nearly 3,850 participants and found that those with low blood levels of vitamin B were significantly more likely to report depressive symptoms. Specifically, individuals with low vitamin B had a 51% higher chance of developing depression compared to those with adequate levels.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults.
9
Improved mood noted
Most Useful Review
The lesson is excellent, presented very well. God willing, it will improve nerves and mood and eliminate depression.
Updated: Apr 2025
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