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Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
25 mg
1,471%
The product is found useful for the following medical conditions
Nausea
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6
USERS' SCORE
Excellent
Based on 19 Reviews
9
4
Vitamin B6 risks in pregnancy
The potential hazards of high doses of vitamin B6 in treating nausea and vomiting in pregnancy: A systematic review.
Most Relevant Research
We investigated the use of vitamin B6 as a common treatment for nausea and vomiting during pregnancy. There has been an ongoing discussion about how effective high doses of this vitamin actually are, and we wanted to shed light on this issue.
Through a systematic review of literature, we examined various studies, focusing on reports that highlighted the effects of high doses of vitamin B6 on pregnant women experiencing nausea. While we found that many women do turn to vitamin B6 to alleviate their symptoms, particularly during the challenging first trimester, the data also raised serious concerns about potential side effects.
A significant portion of the studies reviewed documented adverse reactions in women taking excessive amounts of vitamin B6. These included neurological symptoms such as burning sensations, tingling, and coordination problems. Alarmingly, we also noted a few cases of miscarriage and intrauterine demise among those studied.
Overall, while vitamin B6 is a widely used treatment for nausea during pregnancy, we must exercise caution. The risks associated with high doses cannot be overlooked, particularly when it comes to the health of both the mother and the developing fetus.
Through a systematic review of literature, we examined various studies, focusing on reports that highlighted the effects of high doses of vitamin B6 on pregnant women experiencing nausea. While we found that many women do turn to vitamin B6 to alleviate their symptoms, particularly during the challenging first trimester, the data also raised serious concerns about potential side effects.
A significant portion of the studies reviewed documented adverse reactions in women taking excessive amounts of vitamin B6. These included neurological symptoms such as burning sensations, tingling, and coordination problems. Alarmingly, we also noted a few cases of miscarriage and intrauterine demise among those studied.
Overall, while vitamin B6 is a widely used treatment for nausea during pregnancy, we must exercise caution. The risks associated with high doses cannot be overlooked, particularly when it comes to the health of both the mother and the developing fetus.
9.5
Significant improvement
Most Useful Review
Worked for me for morning sickness. I took one tablet three times a day through my first trimester with significant improvement in my nausea. I couldn’t take Diclegis due to the sedating effect of doxylamine and found this worked well for me. Definitely worth a try!
Insomnia
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8
USERS' SCORE
Good
Based on 2 Reviews
8.7
9
Vitamin B6 could aid insomnia
A combination of melatonin, vitamin B6 and medicinal plants in the treatment of mild-to-moderate insomnia: A prospective pilot study.
Most Relevant Research
We set out to investigate how vitamin B6 contributes to improving sleep quality in individuals experiencing mild to moderate insomnia. Our study involved 40 participants who were given a combination treatment containing melatonin, vitamin B6, and extracts from various medicinal plants.
Over a period of two weeks, participants documented their sleep experiences using a daily electronic diary. We analyzed changes in sleep quality, total sleep duration, and how well our treatment reduced sleep-related daytime impairments. Encouragingly, participants reported a significant improvement in sleep quality, with an average score rise from 5.4 to 7.3 on a 10-point scale.
Although it is difficult to isolate the specific effects of vitamin B6 alone due to its use alongside other ingredients, our findings do suggest that this vitamin, when combined with melatonin and plant extracts, could support better sleep. Importantly, the treatment was well-tolerated, with no serious side effects reported.
Overall, while vitamin B6 on its own wasn’t examined, its inclusion in a combination treatment appears to play a role in enhancing sleep quality for those struggling with insomnia.
Over a period of two weeks, participants documented their sleep experiences using a daily electronic diary. We analyzed changes in sleep quality, total sleep duration, and how well our treatment reduced sleep-related daytime impairments. Encouragingly, participants reported a significant improvement in sleep quality, with an average score rise from 5.4 to 7.3 on a 10-point scale.
Although it is difficult to isolate the specific effects of vitamin B6 alone due to its use alongside other ingredients, our findings do suggest that this vitamin, when combined with melatonin and plant extracts, could support better sleep. Importantly, the treatment was well-tolerated, with no serious side effects reported.
Overall, while vitamin B6 on its own wasn’t examined, its inclusion in a combination treatment appears to play a role in enhancing sleep quality for those struggling with insomnia.
10
Sleeping pill alternative
Most Useful Review
Excellent sleep aid! I had no idea a low dose of B6 in the evening could improve my sleep so much. After suffering from insomnia for over a decade, I used to manage about four hours a night, even with sleeping pills. Now, I’ve been able to cease taking them altogether, and I average about seven to eight hours of solid sleep!
Flu
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Reduced nausea effect
Most Useful Review
These were cost-effective standalone B6 supplements that were lifesaving during my first trimester. They significantly reduced my nausea and blood sugar fluctuations. I recommend consulting your doctor before trying them, though!
Indigestion
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Helps with indigestion
Most Useful Review
Solgar Vitamin B6 25 mg Tablets 100 is a quality brand! It helps significantly with indigestion and has calming properties. After taking too much for a few days, I experienced some stomach pain, which I understand can be a side effect. After lowering the dose, everything returned to normal.
Migraine
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.3
USERS' SCORE
Good
Based on 1 Review
8.6
9
Vitamin B6 shows promise for migraines
Pyridoxine, folate and cobalamin for migraine: A systematic review.
Most Relevant Research
We delved into the potential benefits of vitamin B6 (pyridoxine) in treating migraines, particularly in how it relates to other B vitamins like folate and B12. By examining various studies, we focused on the efficacy of B6 alone and in combination with these other vitamins.
The findings were intriguing! While the management of acute migraine attacks using these vitamins didn’t show promising results in one controlled trial, we noted significant benefits when B6 was used as a preventative measure. In several trials, B6 alone or combined with folate, or with both folate and B12, proved to be effective for adults suffering from migraine with aura—outperforming placebo treatments in most cases.
Interestingly, we also found that while folate as a standalone treatment didn’t yield better outcomes than placebo, the overall safety profile of these vitamins was quite good. Most participants reported only mild gastrointestinal side effects. However, we came across limited data regarding the effects of these vitamins on migraine without aura in both children and adults, making it difficult to draw broader conclusions.
In summary, our exploration of the role of vitamin B6 in migraine protection reveals its potential to aid adults with migraine with aura, though more thorough research is needed for other types, especially in younger populations.
The findings were intriguing! While the management of acute migraine attacks using these vitamins didn’t show promising results in one controlled trial, we noted significant benefits when B6 was used as a preventative measure. In several trials, B6 alone or combined with folate, or with both folate and B12, proved to be effective for adults suffering from migraine with aura—outperforming placebo treatments in most cases.
Interestingly, we also found that while folate as a standalone treatment didn’t yield better outcomes than placebo, the overall safety profile of these vitamins was quite good. Most participants reported only mild gastrointestinal side effects. However, we came across limited data regarding the effects of these vitamins on migraine without aura in both children and adults, making it difficult to draw broader conclusions.
In summary, our exploration of the role of vitamin B6 in migraine protection reveals its potential to aid adults with migraine with aura, though more thorough research is needed for other types, especially in younger populations.
9.5
Highly effective
Most Useful Review
This product is effective for migraines.
Blood Clot
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.3
USERS' SCORE
Good
Based on 1 Review
8.5
9.5
High homocysteine management strategy
Treatable high homocysteine alone or in concert with five other thrombophilias in 1014 patients with thrombotic events.
Most Relevant Research
We explored the effects of high serum homocysteine levels on blood clot risks within a group of 1,014 patients who experienced thrombotic events. This group underwent a thorough evaluation for various thrombophilic conditions. Notably, we found that 12% of these patients had treatable high homocysteine levels.
Among those with high homocysteine, we examined a treatment regimen that included vitamin B6, alongside L-methyl folate and vitamin B12. After approximately 18 months of this combined treatment, we observed significant reductions in homocysteine levels, with many patients reaching normal levels.
Importantly, when high homocysteine was the only identified thrombophilia, those who achieved normalization of their homocysteine levels reported a remarkable decrease in new thrombotic events. Thus, while vitamin B6 plays a role in lowering homocysteine, its specific isolated impact on blood clotting remains unclear as part of the combined therapy.
Overall, our findings highlight the relevance of managing high homocysteine through vitamin treatment to potentially lower the risk of blood clots, especially in individuals with no other identified thrombophilia.
Among those with high homocysteine, we examined a treatment regimen that included vitamin B6, alongside L-methyl folate and vitamin B12. After approximately 18 months of this combined treatment, we observed significant reductions in homocysteine levels, with many patients reaching normal levels.
Importantly, when high homocysteine was the only identified thrombophilia, those who achieved normalization of their homocysteine levels reported a remarkable decrease in new thrombotic events. Thus, while vitamin B6 plays a role in lowering homocysteine, its specific isolated impact on blood clotting remains unclear as part of the combined therapy.
Overall, our findings highlight the relevance of managing high homocysteine through vitamin treatment to potentially lower the risk of blood clots, especially in individuals with no other identified thrombophilia.
8.8
Less clots now
Most Useful Review
I take B6 to increase progesterone. My periods had been beyond heavy, accompanied by large blood clots, common symptoms of low progesterone. After taking Solgar’s B6 twice daily for six weeks, I've noticed improvements. I ovulated, had no spotting, and my period came on time, much lighter with fewer clots. It's still early days, but I feel in control now.
Cold
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Supports hormonal balance
Most Useful Review
I believe it is working. This product has helped support my progesterone during the luteal phase, which seems to have extended my cycle and raised my basal temperature. I no longer feel cold to the bones all the time, and my period has become manageable. I will continue taking this alongside B12.
Menopause
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.2
USERS' SCORE
Good
Based on 2 Reviews
8.5
8
Vitamin B6 may delay menopause
Dietary intake and age at natural menopause: results from the UK Women's Cohort Study.
Most Relevant Research
We investigated how dietary factors, particularly vitamin B6, influence the timing of natural menopause in women. Our study focused on women aged 40 to 65 who completed a food frequency questionnaire and recorded their reproductive history.
Over a 4-year follow-up period, we found that a higher intake of vitamin B6 was associated with a delay in the onset of menopause. Specifically, each additional milligram of vitamin B6 consumed each day was linked with a postponement of menopause by 0.6 years. While this suggests that increasing vitamin B6 intake could be beneficial for delaying menopause, it’s important to note that this effect was not isolated from other dietary influences, which may complicate our understanding of its specific role.
We also observed that certain foods like oily fish and fresh legumes were associated with later menopause, while refined pasta and rice were linked to earlier menopause. Our findings underline the potential influence of diet on menopause timing, though we must approach the effects of vitamin B6 with the understanding that it may not act alone.
Over a 4-year follow-up period, we found that a higher intake of vitamin B6 was associated with a delay in the onset of menopause. Specifically, each additional milligram of vitamin B6 consumed each day was linked with a postponement of menopause by 0.6 years. While this suggests that increasing vitamin B6 intake could be beneficial for delaying menopause, it’s important to note that this effect was not isolated from other dietary influences, which may complicate our understanding of its specific role.
We also observed that certain foods like oily fish and fresh legumes were associated with later menopause, while refined pasta and rice were linked to earlier menopause. Our findings underline the potential influence of diet on menopause timing, though we must approach the effects of vitamin B6 with the understanding that it may not act alone.
8
Helped mood swings
Most Useful Review
Helped with mood swings. This product genuinely helped alleviate some mood swings I was experiencing during perimenopause.
Cancer
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.8
USERS' SCORE
Good
Based on 1 Review
8.3
9
Vitamin B6 pathway affects cancer survival
Vitamin B6 Pathway Maintains Glioblastoma Cell Survival in 3D Spheroid Cultures.
Most Relevant Research
We explored the role of the vitamin B6 pathway in glioblastoma, a particularly aggressive form of brain cancer. Through a detailed analysis involving various cell cultures, we noted significant changes in vitamin B6-related metabolites when comparing 3D spheroid cultures to traditional 2D monolayers.
This discovery led us to investigate further the implications of these findings for cancer cell survival. We found that using hydralazine, a compound that effectively reduces vitamin B6 levels, triggered cell death in 3D GBM spheroid cultures.
Our results suggest that targeting the vitamin B6 pathway could offer a new avenue for developing treatments for this challenging cancer. This innovative approach highlights the necessity of understanding metabolic processes within tumor environments for creating effective therapies.
This discovery led us to investigate further the implications of these findings for cancer cell survival. We found that using hydralazine, a compound that effectively reduces vitamin B6 levels, triggered cell death in 3D GBM spheroid cultures.
Our results suggest that targeting the vitamin B6 pathway could offer a new avenue for developing treatments for this challenging cancer. This innovative approach highlights the necessity of understanding metabolic processes within tumor environments for creating effective therapies.
6.8
Medical backing
Most Useful Review
B-6 25 mg is highly convenient. My grandfather, a GP, believed quality balanced vitamins could prevent certain cancers, a view later supported by medical evidence. I personally require additional B-6 and find Solgar the sole manufacturer offering 25 mg strength. However, one must be cautious not to exceed recommended daily intakes due to potential risks to the nervous system and liver. I advise thorough research before purchasing vitamin B(s).
