Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
25 mg
1,471%
The product is found useful for the following medical conditions
Allergies details
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 7 Reviews
8.7
8
We explored the effects of vitamin B6, specifically its active form called pyridoxal phosphate (PLP), on allergic responses. Our research focused on how this vitamin might influence interleukin-33 (IL-33), a key cytokine involved in type 2 inflammation, typically seen in asthma and other allergic conditions.
We found that healthy individuals had higher levels of PLP in their blood compared to asthma patients. Notably, lower PLP levels correlated with worse lung function and increased inflammation in those with asthma. In tests using mouse models of lung inflammation, we observed that PLP significantly reduced the type 2 immune response, suggesting a protective role against allergic reactions.
Delving deeper, we identified that the conversion of pyridoxal to PLP was critical for regulating IL-33 stability. Moreover, we found that a protein called MDM2 contributed to IL-33's stability by facilitating its degradation. Using PLP helped to decrease IL-33 levels in the lungs and enhance the regulation of this protein, providing a potential new avenue for allergy treatment.
Additionally, inhalation of PLP showed promise in mitigating asthma-related symptoms in mouse models. Overall, our findings indicate that vitamin B6 could serve as a beneficial strategy in managing type 2 inflammation and offer new hope for developing effective treatments for allergy-related diseases.
We found that healthy individuals had higher levels of PLP in their blood compared to asthma patients. Notably, lower PLP levels correlated with worse lung function and increased inflammation in those with asthma. In tests using mouse models of lung inflammation, we observed that PLP significantly reduced the type 2 immune response, suggesting a protective role against allergic reactions.
Delving deeper, we identified that the conversion of pyridoxal to PLP was critical for regulating IL-33 stability. Moreover, we found that a protein called MDM2 contributed to IL-33's stability by facilitating its degradation. Using PLP helped to decrease IL-33 levels in the lungs and enhance the regulation of this protein, providing a potential new avenue for allergy treatment.
Additionally, inhalation of PLP showed promise in mitigating asthma-related symptoms in mouse models. Overall, our findings indicate that vitamin B6 could serve as a beneficial strategy in managing type 2 inflammation and offer new hope for developing effective treatments for allergy-related diseases.
9
Trusted high quality
Most Useful Review
Bestseller! The Solgar brand needs no introduction—it's one of the finest supplements on iHerb. As someone with allergies, I can attest to its quality; I’ve never experienced negative reactions. This vitamin B6, at an optimal 25 mg dosage for adults, is highly effective for prevention. I usually take it separately, as I prefer controlling dosage. It's wise to take it with food, and it's best in the afternoon or at night. I highly recommend it due to its superior quality.
Insomnia details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8
USERS' SCORE
Good
Based on 4 Reviews
8.7
9
We set out to investigate how vitamin B6 contributes to improving sleep quality in individuals experiencing mild to moderate insomnia. Our study involved 40 participants who were given a combination treatment containing melatonin, vitamin B6, and extracts from various medicinal plants.
Over a period of two weeks, participants documented their sleep experiences using a daily electronic diary. We analyzed changes in sleep quality, total sleep duration, and how well our treatment reduced sleep-related daytime impairments. Encouragingly, participants reported a significant improvement in sleep quality, with an average score rise from 5.4 to 7.3 on a 10-point scale.
Although it is difficult to isolate the specific effects of vitamin B6 alone due to its use alongside other ingredients, our findings do suggest that this vitamin, when combined with melatonin and plant extracts, could support better sleep. Importantly, the treatment was well-tolerated, with no serious side effects reported.
Overall, while vitamin B6 on its own wasn’t examined, its inclusion in a combination treatment appears to play a role in enhancing sleep quality for those struggling with insomnia.
Over a period of two weeks, participants documented their sleep experiences using a daily electronic diary. We analyzed changes in sleep quality, total sleep duration, and how well our treatment reduced sleep-related daytime impairments. Encouragingly, participants reported a significant improvement in sleep quality, with an average score rise from 5.4 to 7.3 on a 10-point scale.
Although it is difficult to isolate the specific effects of vitamin B6 alone due to its use alongside other ingredients, our findings do suggest that this vitamin, when combined with melatonin and plant extracts, could support better sleep. Importantly, the treatment was well-tolerated, with no serious side effects reported.
Overall, while vitamin B6 on its own wasn’t examined, its inclusion in a combination treatment appears to play a role in enhancing sleep quality for those struggling with insomnia.
10
Sleeping pill alternative
Most Useful Review
63 people found this helpful
Excellent sleep aid! I had no idea a low dose of B6 in the evening could improve my sleep so much. After suffering from insomnia for over a decade, I used to manage about four hours a night, even with sleeping pills. Now, I’ve been able to cease taking them altogether, and I average about seven to eight hours of solid sleep!
Ear Infection details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.5
9
Nausea relief
Most Useful Review
2 people found this helpful
I took it for morning sickness during early pregnancy. My vomiting and nausea were significantly relieved. It helped me a great deal.
Knee Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 2 Reviews
8.5
8
We conducted an open-label study to assess how a seaweed extract formulation, which includes Vitamin B6, impacts knee osteoarthritis symptoms. Involving 12 participants with confirmed knee osteoarthritis, we divided them into two groups receiving either 100 mg or 1000 mg of the extract daily.
Our primary focus was to measure overall joint health through a score that looked at pain, stiffness, and physical activity challenges over twelve weeks. While we found a general improvement in osteoarthritis symptoms with increased dosage of the extract, it’s important to note that Vitamin B6 was part of a combined treatment with other nutrients. This means we cannot determine the isolated effect of Vitamin B6 on knee pain from our findings alone.
We observed no significant safety concerns during the study, and the treatment was well tolerated. However, further research in a larger, controlled study is needed to fully understand the role of Vitamin B6 within this formulation and its true effectiveness on knee osteoarthritis.
Our primary focus was to measure overall joint health through a score that looked at pain, stiffness, and physical activity challenges over twelve weeks. While we found a general improvement in osteoarthritis symptoms with increased dosage of the extract, it’s important to note that Vitamin B6 was part of a combined treatment with other nutrients. This means we cannot determine the isolated effect of Vitamin B6 on knee pain from our findings alone.
We observed no significant safety concerns during the study, and the treatment was well tolerated. However, further research in a larger, controlled study is needed to fully understand the role of Vitamin B6 within this formulation and its true effectiveness on knee osteoarthritis.
9
Leg pain relief
Most Useful Review
For a long time, I have suffered from knee pain and fatigue. A friend suggested I try vitamin B6. I took it at night, and by morning, I was amazed; my knees no longer hurt, and the heaviness in my legs had vanished.
Migraine details
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.1
USERS' SCORE
Good
Based on 2 Reviews
8.5
7
We delved into the relationship between migraine and vitamins known to lower homocysteine levels, specifically B6, folate, and B12. Our systematic search revealed twelve articles, indicating that while managing acute migraines didn’t yield strong results, B6 supplementation showed significant benefits in preventing migraine with aura when compared to placebo.
Unfortunately, folate alone didn’t perform better than placebo for migraines, and data on migraines without aura was limited. Overall, these vitamins seem to have a safe profile, especially for migraine with aura in adults, although more high-quality trials are needed for broader conclusions.
Unfortunately, folate alone didn’t perform better than placebo for migraines, and data on migraines without aura was limited. Overall, these vitamins seem to have a safe profile, especially for migraine with aura in adults, although more high-quality trials are needed for broader conclusions.
9
Highly effective
Most Useful Review
3 people found this helpful
This product is effective for migraines.
Anxiety details
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.2
USERS' SCORE
Good
Based on 3 Reviews
8.4
9.5
We looked into how pyridoxine, or vitamin B6, could impact anxiety, particularly in those with a deficiency. A case study featuring a 57-year-old man with chronic alcoholism showed that he had developed anxiety and other neurological symptoms despite being on anti-epileptic medications. After discovering he had a pyridoxine deficiency, his symptoms, including anxiety, completely disappeared with vitamin B6 treatment. This highlights the potential importance of checking for pyridoxine levels in patients presenting with neurological issues, especially when anxiety is involved.
9
Drastic anxiety reduction
Most Useful Review
3 people found this helpful
I have suffered from continuous anxiety for years, and after taking B6, my anxiety has nearly vanished. It occurs less frequently now, a drastic change from before. I take just 1/4 of the tablet and adjust the dosage based on my needs. I believe I was deficient in B6 due to prolonged stress, which can severely impact your mental and physical well-being.
Brain Tumor details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 10 Reviews
8.4
8
We explored the impact of the vitamin B6 pathway on glioblastoma, a challenging and aggressive brain cancer. Specifically, we assessed how different cell cultures—2D monolayers and 3D spheroids—responded to treatments that alter vitamin B6 levels. Through comprehensive metabolomics analysis, we found notable differences in the levels of vitamin B6-related metabolites between these two culture methods.
Our key finding was that when we used hydralazine, a small molecule known to lower vitamin B6 levels, it induced cell death specifically in the 3D spheroid cultures of glioblastoma. This suggests a potential new therapeutic strategy targeting the vitamin B6 pathway could benefit glioblastoma treatment.
Thus, this study highlights a novel approach to tackle this aggressive cancer by focusing on the metabolic alterations within the tumor microenvironment, particularly through vitamin B6 modulation.
Our key finding was that when we used hydralazine, a small molecule known to lower vitamin B6 levels, it induced cell death specifically in the 3D spheroid cultures of glioblastoma. This suggests a potential new therapeutic strategy targeting the vitamin B6 pathway could benefit glioblastoma treatment.
Thus, this study highlights a novel approach to tackle this aggressive cancer by focusing on the metabolic alterations within the tumor microenvironment, particularly through vitamin B6 modulation.
9
Well tolerated supplement
Most Useful Review
5 people found this helpful
I ordered Vitamin B6 alongside Magnesium. The tablets are small and easy to swallow, well tolerated by my body. It effectively enhances brain performance, as well as memory and mood.
Flu details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.4
9
Reduced nausea effect
Most Useful Review
4 people found this helpful
These were cost-effective standalone B6 supplements that were lifesaving during my first trimester. They significantly reduced my nausea and blood sugar fluctuations. I recommend consulting your doctor before trying them, though!
Headache details
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.3
USERS' SCORE
Good
Based on 6 Reviews
8.4
8
We explored how vitamin B6, along with other B vitamins like folate and B12, might help in preventing migraines. Through a thorough review of existing research, we discovered that while vitamin B6 showed some promise in reducing migraines with aura in adults, the results aren’t as clear-cut for individuals suffering from other forms of headaches. In fact, in the context of treating acute migraine attacks, the benefits of these vitamins have not been supported by strong evidence from studies.
We found several trials that looked specifically at vitamin B6 for migraine prevention. The results were generally positive, especially for those experiencing migraines with aura, where vitamin B6 exhibited significant benefits against placebo in multiple studies. However, when it comes to folate, using it alone didn’t show improved outcomes compared to placebo. Limited data on children and those suffering from migraines without aura prevented us from making definitive conclusions about vitamin B6’s effectiveness across different demographics.
Overall, there’s a potential positive effect of vitamin B6 in managing migraines, particularly in adults with aura. While the safety profile appears favorable, we advocate for more high-quality research to clarify its role in treating various types of migraines.
We found several trials that looked specifically at vitamin B6 for migraine prevention. The results were generally positive, especially for those experiencing migraines with aura, where vitamin B6 exhibited significant benefits against placebo in multiple studies. However, when it comes to folate, using it alone didn’t show improved outcomes compared to placebo. Limited data on children and those suffering from migraines without aura prevented us from making definitive conclusions about vitamin B6’s effectiveness across different demographics.
Overall, there’s a potential positive effect of vitamin B6 in managing migraines, particularly in adults with aura. While the safety profile appears favorable, we advocate for more high-quality research to clarify its role in treating various types of migraines.
9
Improves sleep, relieves headaches
Most Useful Review
Fantastic! I take this B6 with magnesium, which improves my sleep and greatly alleviates headaches. It works wonders for me.
Blood Clot details
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.3
USERS' SCORE
Good
Based on 2 Reviews
8.3
9.5
We explored the effects of high serum homocysteine levels on blood clot risks within a group of 1,014 patients who experienced thrombotic events. This group underwent a thorough evaluation for various thrombophilic conditions. Notably, we found that 12% of these patients had treatable high homocysteine levels.
Among those with high homocysteine, we examined a treatment regimen that included vitamin B6, alongside L-methyl folate and vitamin B12. After approximately 18 months of this combined treatment, we observed significant reductions in homocysteine levels, with many patients reaching normal levels.
Importantly, when high homocysteine was the only identified thrombophilia, those who achieved normalization of their homocysteine levels reported a remarkable decrease in new thrombotic events. Thus, while vitamin B6 plays a role in lowering homocysteine, its specific isolated impact on blood clotting remains unclear as part of the combined therapy.
Overall, our findings highlight the relevance of managing high homocysteine through vitamin treatment to potentially lower the risk of blood clots, especially in individuals with no other identified thrombophilia.
Among those with high homocysteine, we examined a treatment regimen that included vitamin B6, alongside L-methyl folate and vitamin B12. After approximately 18 months of this combined treatment, we observed significant reductions in homocysteine levels, with many patients reaching normal levels.
Importantly, when high homocysteine was the only identified thrombophilia, those who achieved normalization of their homocysteine levels reported a remarkable decrease in new thrombotic events. Thus, while vitamin B6 plays a role in lowering homocysteine, its specific isolated impact on blood clotting remains unclear as part of the combined therapy.
Overall, our findings highlight the relevance of managing high homocysteine through vitamin treatment to potentially lower the risk of blood clots, especially in individuals with no other identified thrombophilia.
7.5
Less clots now
Most Useful Review
44 people found this helpful
I take B6 to increase progesterone. My periods had been beyond heavy, accompanied by large blood clots, common symptoms of low progesterone. After taking Solgar’s B6 twice daily for six weeks, I've noticed improvements. I ovulated, had no spotting, and my period came on time, much lighter with fewer clots. It's still early days, but I feel in control now.
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6
USERS' SCORE
Good
Based on 4 Reviews
8.3
4
Vitamin B6 and CFS relationship
We observed the functional status of vitamin B6, also known as pyridoxine, in patients suffering from chronic fatigue syndrome (CFS). Our study involved comparing 12 untreated CFS patients with 18 healthy individuals, matched for age and sex.
To assess the vitamin B6 status, we measured aspartate aminotransferase (AST) levels, among other key enzymes. Our findings revealed that the basal activity of AST was significantly lower in the CFS patients compared to the healthy controls.
This trend was consistent for other vitamins related to fatigue, like riboflavin and thiamine, where basal activity was also found to be lower in CFS patients. Importantly, even after supplementation in the lab, the overall activation ratios between both groups didn’t differ significantly.
Although our results suggest a reduced functional status of vitamin B6 in CFS patients, the lack of significant changes after vitamin activation indicates that vitamin B6 treatment alone may not be a definitive answer to combatting chronic fatigue syndrome. More research is necessary to understand the full role of B6 and its potential benefits.
To assess the vitamin B6 status, we measured aspartate aminotransferase (AST) levels, among other key enzymes. Our findings revealed that the basal activity of AST was significantly lower in the CFS patients compared to the healthy controls.
This trend was consistent for other vitamins related to fatigue, like riboflavin and thiamine, where basal activity was also found to be lower in CFS patients. Importantly, even after supplementation in the lab, the overall activation ratios between both groups didn’t differ significantly.
Although our results suggest a reduced functional status of vitamin B6 in CFS patients, the lack of significant changes after vitamin activation indicates that vitamin B6 treatment alone may not be a definitive answer to combatting chronic fatigue syndrome. More research is necessary to understand the full role of B6 and its potential benefits.
9
Increased energy
Most Useful Review
Excellent vitamins! Magnesium is my favourite, especially from this manufacturer, which truly deserves praise. After a week, my evening drowsiness and lethargy disappeared. I feel far more cheerful, wake up easily, and accomplish more each day without fatigue—it’s like a propeller! My mood has improved significantly, along with a newfound desire to engage in sports. I find it convenient to take without the need for long breaks.
Heart Attack details
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.2
USERS' SCORE
Good
Based on 4 Reviews
8.3
9
We explored the potential of vitamin B6 (VB6) in promoting recovery after heart attacks, specifically its role in angiogenesis, which is the formation of new blood vessels. The study aimed to determine whether VB6 could help prevent cardiac dysfunction following acute myocardial infarction (AMI).
To assess the effects of VB6, we conducted both in vitro experiments, examining endothelial cell behavior, and in vivo tests using mice with heart attacks. We discovered that VB6 significantly enhanced cell migration and tubule formation in human umbilical vein endothelial cells, which are critical for blood vessel formation. This process was linked to increased activity of a protein called AMP-activated protein kinase (AMPK).
Interestingly, our findings showed that these beneficial effects of VB6 were reversed when we introduced AMPK inhibitors. This leads us to conclude that VB6 promotes heart recovery by activating AMPK, which in turn supports angiogenesis following AMI. In practical terms, long-term VB6 supplementation after heart attacks led to improved heart function and increased new blood vessel formation in mice, making this vitamin a promising candidate for heart recovery therapies.
To assess the effects of VB6, we conducted both in vitro experiments, examining endothelial cell behavior, and in vivo tests using mice with heart attacks. We discovered that VB6 significantly enhanced cell migration and tubule formation in human umbilical vein endothelial cells, which are critical for blood vessel formation. This process was linked to increased activity of a protein called AMP-activated protein kinase (AMPK).
Interestingly, our findings showed that these beneficial effects of VB6 were reversed when we introduced AMPK inhibitors. This leads us to conclude that VB6 promotes heart recovery by activating AMPK, which in turn supports angiogenesis following AMI. In practical terms, long-term VB6 supplementation after heart attacks led to improved heart function and increased new blood vessel formation in mice, making this vitamin a promising candidate for heart recovery therapies.
9
Heartbeat reduction
Most Useful Review
1 people found this helpful
I liked the vitamin; after taking it, my well-being improved significantly, the stabbing in my heart area ceased, and my heartbeat slowed down, leading to a noticeable positive change.
Premenstrual Syndrome details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 8 Reviews
8.3
9
Helps with sleep
Most Useful Review
14 people found this helpful
I took it alongside magnesium, and it worked well. I began to sleep better, the cramps vanished, my nerves calmed, and premenstrual syndrome no longer bothered me. The tablets are small and easy to take.
Anemia details
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.7
USERS' SCORE
Good
Based on 5 Reviews
8.2
9.5
We observed a compelling case involving a 32-year-old pregnant woman who experienced severe anemia during her pregnancy. This specific type of anemia, known as sideroblastic anemia, is quite rare in expectant mothers. The patient had been feeling weak and had heart palpitations for two weeks when she came to the emergency room.
Testing revealed she had an alarming hemoglobin level of just 4.2 g/dl, indicating severe anemia, along with a notably low reticulocyte count. What made this case particularly interesting was her history of recurrent anemia, which occurred exclusively during her pregnancies.
Upon examining her bone marrow, doctors found numerous ring sideroblasts, which confirmed the diagnosis of sideroblastic anemia. Further investigation uncovered extremely low levels of pyridoxine, or vitamin B6, in her system. After administering vitamin B6 replacement therapy, her hemoglobin levels improved significantly without the need for blood transfusions, highlighting the vitamin’s role in managing this type of anemia during pregnancy.
Testing revealed she had an alarming hemoglobin level of just 4.2 g/dl, indicating severe anemia, along with a notably low reticulocyte count. What made this case particularly interesting was her history of recurrent anemia, which occurred exclusively during her pregnancies.
Upon examining her bone marrow, doctors found numerous ring sideroblasts, which confirmed the diagnosis of sideroblastic anemia. Further investigation uncovered extremely low levels of pyridoxine, or vitamin B6, in her system. After administering vitamin B6 replacement therapy, her hemoglobin levels improved significantly without the need for blood transfusions, highlighting the vitamin’s role in managing this type of anemia during pregnancy.
7.5
Increases energy levels
Most Useful Review
3 people found this helpful
After taking vitamin B6, I noticed a significant boost in energy and less weakness. My gums also improved, which I attributed to previously unnoticed anaemia from a B vitamin deficiency. I had struggled with these issues for a long time.
Leg Cramps details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 8 Reviews
8.2
9
Calms cramps
Most Useful Review
14 people found this helpful
Vitamin B6 with magnesium has worked wonders for me. I began to sleep better, leg cramps vanished, and my nerves settled down, leading to a reduction in PMS symptoms. The tablets are small and easy to take, making it a convenient choice.
Menopause details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.2
USERS' SCORE
Good
Based on 4 Reviews
8.2
8
We investigated how dietary factors, particularly vitamin B6, influence the timing of natural menopause in women. Our study focused on women aged 40 to 65 who completed a food frequency questionnaire and recorded their reproductive history.
Over a 4-year follow-up period, we found that a higher intake of vitamin B6 was associated with a delay in the onset of menopause. Specifically, each additional milligram of vitamin B6 consumed each day was linked with a postponement of menopause by 0.6 years. While this suggests that increasing vitamin B6 intake could be beneficial for delaying menopause, it’s important to note that this effect was not isolated from other dietary influences, which may complicate our understanding of its specific role.
We also observed that certain foods like oily fish and fresh legumes were associated with later menopause, while refined pasta and rice were linked to earlier menopause. Our findings underline the potential influence of diet on menopause timing, though we must approach the effects of vitamin B6 with the understanding that it may not act alone.
Over a 4-year follow-up period, we found that a higher intake of vitamin B6 was associated with a delay in the onset of menopause. Specifically, each additional milligram of vitamin B6 consumed each day was linked with a postponement of menopause by 0.6 years. While this suggests that increasing vitamin B6 intake could be beneficial for delaying menopause, it’s important to note that this effect was not isolated from other dietary influences, which may complicate our understanding of its specific role.
We also observed that certain foods like oily fish and fresh legumes were associated with later menopause, while refined pasta and rice were linked to earlier menopause. Our findings underline the potential influence of diet on menopause timing, though we must approach the effects of vitamin B6 with the understanding that it may not act alone.
9
Restores menstrual cycle
Most Useful Review
For over six months, I have been using iHerb products, including vitamin B6 as recommended by my doctor. At 48, I am approaching menopause, and hormonal disruptions have begun. I did not anticipate such rapid results. My menstruation has returned, my body feels rejuvenated, and it is functioning normally again! I am incredibly satisfied with the products and take them as part of a comprehensive approach. Thank you so much!
Irritable Bowel Syndrome details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.2
USERS' SCORE
Good
Based on 7 Reviews
8.1
7
We explored the relationship between vitamin B6 intake and the severity of symptoms in individuals with irritable bowel syndrome (IBS). Through a study involving 17 participants diagnosed with IBS according to the Rome II criteria, we gathered daily symptom reports and food intake logs over a week.
Our findings indicated that the only significant dietary component linked to symptom severity was vitamin B6. Participants generally consumed less than the recommended daily intake of vitamin B6, averaging just 0.9 mg per day, compared to the suggested amounts of 1.6 mg for men and 1.2 mg for women. Notably, a higher symptom score correlated with lower vitamin B6 consumption.
This suggests that individuals with IBS may benefit from increasing their vitamin B6 intake. Although this study has limitations—being small in scale and cross-sectional—it highlights a potential dietary factor that may impact the management of IBS symptoms.
Our findings indicated that the only significant dietary component linked to symptom severity was vitamin B6. Participants generally consumed less than the recommended daily intake of vitamin B6, averaging just 0.9 mg per day, compared to the suggested amounts of 1.6 mg for men and 1.2 mg for women. Notably, a higher symptom score correlated with lower vitamin B6 consumption.
This suggests that individuals with IBS may benefit from increasing their vitamin B6 intake. Although this study has limitations—being small in scale and cross-sectional—it highlights a potential dietary factor that may impact the management of IBS symptoms.
10
Less stress
Most Useful Review
Despite my initial dislike of Solgar, these vitamins are brilliant! They are 100% effective. I've become calmer, less irritable, and the stress has passed, allowing me to stop worrying about trivial matters.
Nausea details
SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.5
USERS' SCORE
Good
Based on 27 Reviews
8.1
9
We evaluated the effects of various treatments for nausea during early pregnancy, focusing on pyridoxine, or vitamin B6. Analyzing 28 trials, we found that pyridoxine showed promise in reducing nausea severity for those with milder symptoms. While anti-emetic medications overall helped reduce nausea significantly, we noted that more information is needed on their side effects and impact on fetal outcomes. Nevertheless, pyridoxine stands out as a useful option, with no evidence linking it to adverse fetal effects.
9
Significant improvement
Most Useful Review
57 people found this helpful
Worked for me for morning sickness. I took one tablet three times a day through my first trimester with significant improvement in my nausea. I couldn’t take Diclegis due to the sedating effect of doxylamine and found this worked well for me. Definitely worth a try!
Sleep Apnea details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 17 Reviews
8.1
9
Preventive measure
Most Useful Review
6 people found this helpful
I have been taking Solgar’s vitamin B6 for years in various doses and find the quality excellent. This dosage (25 mg) is preventive, while higher amounts are for deficiencies. I took it with magnesium to promote restful sleep, reduce anxiety, and alleviate PMS. I hope my feedback helps others!
Autoimmune Disorder details
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.2
USERS' SCORE
Good
Based on 3 Reviews
8
8
Vitamin B6 improves cognitive function
We conducted an intriguing study that looked into how vitamin B6 affects cognitive function in patients with Neuromyelitis Optica Spectrum Disorder (NMOSD). This autoimmune disorder often brings along cognitive challenges, so understanding potential dietary influences could be beneficial.
By surveying 24 NMOSD patients at Sina Hospital in Tehran, we gathered detailed dietary habits through a comprehensive food frequency questionnaire. The cognitive abilities of participants were assessed using the Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS) battery, which allowed us to evaluate their mental performance thoroughly.
Our findings were particularly interesting: we observed a positive correlation between the amount of dietary vitamin B6 consumed and cognitive function. Specifically, higher intake was linked to better performance in verbal and learning memory, as well as working memory and processing speed. This suggests that boosting vitamin B6 intake might help enhance cognitive functioning in NMOSD patients, which is encouraging given the prevalence of cognitive issues in this group.
Overall, our study opens up promising pathways for dietary intervention in managing cognitive impairment related to autoimmune disorders like NMOSD.
By surveying 24 NMOSD patients at Sina Hospital in Tehran, we gathered detailed dietary habits through a comprehensive food frequency questionnaire. The cognitive abilities of participants were assessed using the Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS) battery, which allowed us to evaluate their mental performance thoroughly.
Our findings were particularly interesting: we observed a positive correlation between the amount of dietary vitamin B6 consumed and cognitive function. Specifically, higher intake was linked to better performance in verbal and learning memory, as well as working memory and processing speed. This suggests that boosting vitamin B6 intake might help enhance cognitive functioning in NMOSD patients, which is encouraging given the prevalence of cognitive issues in this group.
Overall, our study opens up promising pathways for dietary intervention in managing cognitive impairment related to autoimmune disorders like NMOSD.
9
Apathy relief
Most Useful Review
2 people found this helpful
I had no postpartum depression after my third birth thanks to vitamin B6, which I discovered on a friend's recommendation. It significantly helped me recover and combat apathy and depression.
Depression details
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.9
USERS' SCORE
Good
Based on 6 Reviews
8
9
We explored the potential of vitamin B6 in treating depression, particularly how it compares to commonly used antidepressants. In our experiment, male mice were given a single dose of Bacillus-Calmette-Guerin (BCG) to induce depressive-like behaviors. Following this, we administered vitamin B6 alongside popular antidepressants such as fluoxetine, imipramine, and venlafaxine, to see how effectively each treatment mitigated symptoms over 14 days.
Our findings highlighted that vitamin B6 was effective in alleviating depression in the mice, just like the other antidepressant medications. The animals displayed significant improvements in both despair and anhedonia—key indicators of depression. Specifically, we noticed a decrease in immobility time during a forced swim test, indicating reduced despair. Plus, the latency to feed and food consumption improved significantly, showing that vitamin B6 helped counteract the depressive behaviors caused by BCG.
Overall, our research suggests that vitamin B6 can be a powerful ally in preventing depression, similar in effectiveness to some existing antidepressant drugs. We believe this opens the door for further clinical research on vitamin B6 as a potential treatment, especially for those at high risk for depression.
Our findings highlighted that vitamin B6 was effective in alleviating depression in the mice, just like the other antidepressant medications. The animals displayed significant improvements in both despair and anhedonia—key indicators of depression. Specifically, we noticed a decrease in immobility time during a forced swim test, indicating reduced despair. Plus, the latency to feed and food consumption improved significantly, showing that vitamin B6 helped counteract the depressive behaviors caused by BCG.
Overall, our research suggests that vitamin B6 can be a powerful ally in preventing depression, similar in effectiveness to some existing antidepressant drugs. We believe this opens the door for further clinical research on vitamin B6 as a potential treatment, especially for those at high risk for depression.
7.5
Less depression noted
Most Useful Review
1 people found this helpful
I heard that vitamin B6 is helpful for PMS, so I commenced taking it about a week to ten days before my period. I no longer experience headaches, and my depression has also decreased. I will continue this supplement from before my period until it ends.
Acne details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.5
7
We explored the effects of pyridoxine, a form of vitamin B6, on skin health, focusing particularly on its potential benefits for those struggling with acne. Our research indicates that pyridoxine plays a significant role in maintaining the function of the epidermis, the outermost layer of our skin.
Through our examination of normal human epidermal keratinocytes, we observed that pyridoxine enhances the expression of profilaggrin mRNA, a precursor to filaggrin—a key protein involved in skin hydration and barrier function. The results show that treatment with pyridoxine leads to an increased production of filaggrin protein, and this effect is concentration-dependent.
While the study did not isolate findings specifically focused on treating acne alone, the increase in filaggrin production suggests that vitamin B6 might contribute positively to skin conditions related to dryness and irritation, which often accompany acne-prone skin. Our findings suggest that pyridoxine could be a valuable daily care ingredient for those with atopic dermatitis or skin issues associated with low filaggrin levels.
Through our examination of normal human epidermal keratinocytes, we observed that pyridoxine enhances the expression of profilaggrin mRNA, a precursor to filaggrin—a key protein involved in skin hydration and barrier function. The results show that treatment with pyridoxine leads to an increased production of filaggrin protein, and this effect is concentration-dependent.
While the study did not isolate findings specifically focused on treating acne alone, the increase in filaggrin production suggests that vitamin B6 might contribute positively to skin conditions related to dryness and irritation, which often accompany acne-prone skin. Our findings suggest that pyridoxine could be a valuable daily care ingredient for those with atopic dermatitis or skin issues associated with low filaggrin levels.
7.5
Prevents acne
Most Useful Review
I take it to prevent acne and enhance my metabolism.
