Last update
5/5/2026
Reviewed By
Infographics
Overview
SCIENTIFIC SCORE
Likely Ineffective
Based on 2 Researches
4
USERS' SCORE
Good
Based on 3 Reviews
8.3
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
25 mg
1,471%
Top Medical Research Studies
1
B6 supplementation exacerbates acne; individualized approach needed
This review examined how B vitamins affect various skin conditions, including acne. Researchers found that while some B vitamins show promise for skin health, B6 (pyridoxine) actually worsened existing acne in patients who took it as a supplement. The findings suggest that simply adding vitamin supplements isn't a one-size-fits-all solution for skin problems.
Interestingly, other B vitamins like B3 (niacinamide) showed benefits for acne and hyperpigmentation, while B12 caused allergic reactions in some patients. The research emphasizes that skin conditions are complex and may require individualized approaches rather than blanket supplementation strategies.
Interestingly, other B vitamins like B3 (niacinamide) showed benefits for acne and hyperpigmentation, while B12 caused allergic reactions in some patients. The research emphasizes that skin conditions are complex and may require individualized approaches rather than blanket supplementation strategies.
Read More
7
We explored the effects of pyridoxine, a form of vitamin B6, on skin health, focusing particularly on its potential benefits for those struggling with acne. Our research indicates that pyridoxine plays a significant role in maintaining the function of the epidermis, the outermost layer of our skin.
Through our examination of normal human epidermal keratinocytes, we observed that pyridoxine enhances the expression of profilaggrin mRNA, a precursor to filaggrin—a key protein involved in skin hydration and barrier function. The results show that treatment with pyridoxine leads to an increased production of filaggrin protein, and this effect is concentration-dependent.
While the study did not isolate findings specifically focused on treating acne alone, the increase in filaggrin production suggests that vitamin B6 might contribute positively to skin conditions related to dryness and irritation, which often accompany acne-prone skin. Our findings suggest that pyridoxine could be a valuable daily care ingredient for those with atopic dermatitis or skin issues associated with low filaggrin levels.
Through our examination of normal human epidermal keratinocytes, we observed that pyridoxine enhances the expression of profilaggrin mRNA, a precursor to filaggrin—a key protein involved in skin hydration and barrier function. The results show that treatment with pyridoxine leads to an increased production of filaggrin protein, and this effect is concentration-dependent.
While the study did not isolate findings specifically focused on treating acne alone, the increase in filaggrin production suggests that vitamin B6 might contribute positively to skin conditions related to dryness and irritation, which often accompany acne-prone skin. Our findings suggest that pyridoxine could be a valuable daily care ingredient for those with atopic dermatitis or skin issues associated with low filaggrin levels.
Read More
Most Useful Reviews
8
Prevents acne
I take it to prevent acne and enhance my metabolism.
Read More
8
Great for skin
I love taking this alongside zinc every morning. Not only does it support immune health, but it’s fantastic for skin health! I have acne, and these two products work excellently together.
Read More
7
Works for acne
It appears to be effective for acne. I purchased it as a beauty product.
Read More
Medical Researches
SCIENTIFIC SCORE
Likely Ineffective
Based on 2 Researches
4
- All Researches
7
We explored the effects of pyridoxine, a form of vitamin B6, on skin health, focusing particularly on its potential benefits for those struggling with acne. Our research indicates that pyridoxine plays a significant role in maintaining the function of the epidermis, the outermost layer of our skin.
Through our examination of normal human epidermal keratinocytes, we observed that pyridoxine enhances the expression of profilaggrin mRNA, a precursor to filaggrin—a key protein involved in skin hydration and barrier function. The results show that treatment with pyridoxine leads to an increased production of filaggrin protein, and this effect is concentration-dependent.
While the study did not isolate findings specifically focused on treating acne alone, the increase in filaggrin production suggests that vitamin B6 might contribute positively to skin conditions related to dryness and irritation, which often accompany acne-prone skin. Our findings suggest that pyridoxine could be a valuable daily care ingredient for those with atopic dermatitis or skin issues associated with low filaggrin levels.
Through our examination of normal human epidermal keratinocytes, we observed that pyridoxine enhances the expression of profilaggrin mRNA, a precursor to filaggrin—a key protein involved in skin hydration and barrier function. The results show that treatment with pyridoxine leads to an increased production of filaggrin protein, and this effect is concentration-dependent.
While the study did not isolate findings specifically focused on treating acne alone, the increase in filaggrin production suggests that vitamin B6 might contribute positively to skin conditions related to dryness and irritation, which often accompany acne-prone skin. Our findings suggest that pyridoxine could be a valuable daily care ingredient for those with atopic dermatitis or skin issues associated with low filaggrin levels.
Read More
1
B6 supplementation exacerbates acne; individualized approach needed
This review examined how B vitamins affect various skin conditions, including acne. Researchers found that while some B vitamins show promise for skin health, B6 (pyridoxine) actually worsened existing acne in patients who took it as a supplement. The findings suggest that simply adding vitamin supplements isn't a one-size-fits-all solution for skin problems.
Interestingly, other B vitamins like B3 (niacinamide) showed benefits for acne and hyperpigmentation, while B12 caused allergic reactions in some patients. The research emphasizes that skin conditions are complex and may require individualized approaches rather than blanket supplementation strategies.
Interestingly, other B vitamins like B3 (niacinamide) showed benefits for acne and hyperpigmentation, while B12 caused allergic reactions in some patients. The research emphasizes that skin conditions are complex and may require individualized approaches rather than blanket supplementation strategies.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
8
Prevents acne
I take it to prevent acne and enhance my metabolism.
Read More
8
Great for skin
I love taking this alongside zinc every morning. Not only does it support immune health, but it’s fantastic for skin health! I have acne, and these two products work excellently together.
Read More
7
Works for acne
It appears to be effective for acne. I purchased it as a beauty product.
Read More
Frequently Asked Questions
8
Great for skin
I love taking this alongside zinc every morning. Not only does it support immune health, but it’s fantastic for skin health! I have acne, and these two products work excellently together.
7
Works for acne
It appears to be effective for acne. I purchased it as a beauty product.
7
We explored the effects of pyridoxine, a form of vitamin B6, on skin health, focusing particularly on its potential benefits for those struggling with acne. Our research indicates that pyridoxine plays a significant role in maintaining the function of the epidermis, the outermost layer of our skin.
Through our examination of normal human epidermal keratinocytes, we observed that pyridoxine enhances the expression of profilaggrin mRNA, a precursor to filaggrin—a key protein involved in skin hydration and barrier function. The results show that treatment with pyridoxine leads to an increased production of filaggrin protein, and this effect is concentration-dependent.
While the study did not isolate findings specifically focused on treating acne alone, the increase in filaggrin production suggests that vitamin B6 might contribute positively to skin conditions related to dryness and irritation, which often accompany acne-prone skin. Our findings suggest that pyridoxine could be a valuable daily care ingredient for those with atopic dermatitis or skin issues associated with low filaggrin levels.
Through our examination of normal human epidermal keratinocytes, we observed that pyridoxine enhances the expression of profilaggrin mRNA, a precursor to filaggrin—a key protein involved in skin hydration and barrier function. The results show that treatment with pyridoxine leads to an increased production of filaggrin protein, and this effect is concentration-dependent.
While the study did not isolate findings specifically focused on treating acne alone, the increase in filaggrin production suggests that vitamin B6 might contribute positively to skin conditions related to dryness and irritation, which often accompany acne-prone skin. Our findings suggest that pyridoxine could be a valuable daily care ingredient for those with atopic dermatitis or skin issues associated with low filaggrin levels.
References
- Elgharably N, Al Abadie M, Al Abadie M, Ball PA, Morrissey H. Vitamin B group levels and supplementations in dermatology. Dermatol Reports. 2023;15:9511. 10.4081/dr.2022.9511
- Fujishiro M, Yahagi S, Takemi S, Nakahara M, Sakai T, et al. Pyridoxine stimulates filaggrin production in human epidermal keratinocytes. Mol Biol Rep. 2021;48:5513. 10.1007/s11033-021-06563-y
