Magnesium
9.5
Improved well-being
Most Useful Review
I had been experiencing constant sleepiness, headaches, irritability, and depression before starting magnesium. Using Magnesium Caps has helped me assimilate essential vitamins and minerals, thin my blood, and synthesise the hormone of joy. It effectively alleviated insomnia and my migraines, apathy and depression have vanished. I now feel refreshed after six hours of sleep and my mental clarity has improved significantly. I highly recommend it, especially when taken before bedtime!
8.8
Calming effects
Most Useful Review
I bought this for a girl who was experiencing a mild autumn depression. After a few days of use, she found that she was coping better with stress and felt much calmer overall. Her muscles relaxed, and her immune system seemed to be recovering. Importantly, she did not experience any side effects.
Vitamins
8
Fortified yogurt benefits depression treatment
Effects of a Novel Fortified Dairy Product on the Psychological Status and Sleep Quality of Patients with Polycystic Ovary Syndrome: A Double-Blind Randomized Controlled Trial.
Most Relevant Research
We conducted a double-blind randomized controlled trial to explore how a specially fortified yogurt affects depression and sleep quality in women with polycystic ovary syndrome (PCOS). This study involved two groups of participants: one group consumed yogurt enriched with probiotics, vitamin E, and vitamin D, while the other group received a placebo.
After eight weeks of monitoring, we observed a significant improvement in depression levels among those who enjoyed the fortified yogurt compared to the placebo group. This suggests that the combined intake of probiotics, along with vitamins, may help alleviate depressive symptoms in women suffering from PCOS. However, when it comes to sleep quality, the results didn’t show any noticeable improvement, indicating that while certain nutritional interventions can positively affect mood, they may not necessarily enhance sleep.
Overall, our findings point to the potential benefits of nutritional approaches in managing depression, particularly for individuals who may prefer alternatives to traditional antidepressant medications. However, we should remain cautious, as further research is needed to fully understand the individual effects of each component, especially vitamin D, on mental health.
After eight weeks of monitoring, we observed a significant improvement in depression levels among those who enjoyed the fortified yogurt compared to the placebo group. This suggests that the combined intake of probiotics, along with vitamins, may help alleviate depressive symptoms in women suffering from PCOS. However, when it comes to sleep quality, the results didn’t show any noticeable improvement, indicating that while certain nutritional interventions can positively affect mood, they may not necessarily enhance sleep.
Overall, our findings point to the potential benefits of nutritional approaches in managing depression, particularly for individuals who may prefer alternatives to traditional antidepressant medications. However, we should remain cautious, as further research is needed to fully understand the individual effects of each component, especially vitamin D, on mental health.
9.5
Mood improvement
Most Useful Review
The whole B-complex is contained in one capsule. I have noticed real results: Despite dreary, rainy weather, I feel cheerful. This year, the usual autumn depression has not affected me. I respond calmly to work stress, viewing it as part of life. My skin is managing well through the autumn-winter transition, free from dryness and tightness. My joints are also not causing issues.
Hypericum Perforatum
10
No more anxiety
Most Useful Review
No More Depression or Anxiety attacks! My family has a strong history of depression, and I began to notice signs in myself around age 35. My doctor prescribed various medications, but they didn’t work well and caused severe anxiety attacks. After reading about St. John’s Wort's success in Europe, I decided to try it. I stopped all prescriptions and have been using St. John’s Wort for 15 years now. I am free from depression and anxiety attacks, feeling quite mellow instead. I take 2 in the morning and 1 at noon. I’m very pleased with the quality and price of the Now Foods brand.
8.8
Calmer and brighter
Most Useful Review
I did not expect such an effective result. I feel calmer, and my sleep has improved significantly. The depression has largely disappeared. After two weeks, I forgot to take it regularly, as I had developed interests and energy I had lacked before. Now, I only take it occasionally when my nerves act up.
Probiotics
8
Probiotic yogurt alleviates depression
Effects of a Novel Fortified Dairy Product on the Psychological Status and Sleep Quality of Patients with Polycystic Ovary Syndrome: A Double-Blind Randomized Controlled Trial.
Most Relevant Research
We explored the effects of fortified yogurt on women with polycystic ovary syndrome (PCOS) over an 8-week period. In this randomized, double-blind study, one group enjoyed yogurt enriched with probiotics, vitamin E, and vitamin D, while the other had a standard yogurt placebo.
Participants in the yogurt group showed significant improvement in depression levels compared to the placebo group, though no gains were noted in sleep quality. This suggests that incorporating probiotics in dietary interventions may help manage depression in PCOS patients, serving as an alternative for those hesitant to use traditional antidepressants. However, we recognize the need for further research to solidify these findings.
Participants in the yogurt group showed significant improvement in depression levels compared to the placebo group, though no gains were noted in sleep quality. This suggests that incorporating probiotics in dietary interventions may help manage depression in PCOS patients, serving as an alternative for those hesitant to use traditional antidepressants. However, we recognize the need for further research to solidify these findings.
8.8
Effective for depression
Most Useful Review
I am satisfied with these probiotics, which support emotional well-being. They contain strains that help calm feelings, relieve stress, and promote relaxation. I previously took a different brand last winter but found similar strains. This product particularly enhanced my mood, which was crucial given my seasonal depression. I noticed substantial improvement in my feelings, likely due to the probiotic strains used, rather than just an ingredient like Ash, which I consumed separately. Unlike my previous product, this one doesn't compromise mood support. It even contains acacia fibre, beneficial for gut health, and I plan to repurchase.
Vitamin B Complex
9.5
Reduced insomnia
Most Useful Review
This is the best B vitamin complex. It saved me from insomnia and mild depression, providing energy, focus, and improved mood. The can is large enough for two courses, making it economical. However, it's unfortunate that they are no longer available for order to Russia.
9.5
Increased vitality
Most Useful Review
I've been taking this B vitamin complex for two months. Even with a prophylactic dose of one capsule, I've noticed an increase in vitality, endurance against stress, and improved mood. These vitamins are highly effective for me, and I will continue to purchase them.
Melatonin
9.5
Menopause relief
Most Useful Review
Melatonin saved me from insomnia caused by menopause. Despite being terrified of potential side effects, I tried it and found it effective. One hour before sleep, I feel drowsy and able to fall asleep easily after struggling for ages. Initially, I used it every two days, but after a month, I could sleep without it. It feels like a memory inside my body.
9.5
Trauma recovery
Most Useful Review
Following a severe trauma, I struggled with sleep and depression. These melatonin tablets help me relax and fall asleep within half an hour. I highly recommend this product as it has been invaluable in restoring my ability to sleep.
Vitamin Bs
8
Vitamin B6 linked to depression
Associations of Dietary Intake of Vitamin B6 and Plasma Pyridoxal 5'-Phosphate Level With Depression in US Adults: Findings From NHANES 2005-2010.
Most Relevant Research
We explored the connections between dietary vitamin B6 intake and depression risk in adults, using data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2005 and 2010. Our study analyzed information from nearly 25,000 individuals aged 20 and over to see how the levels of a specific form of vitamin B6, known as pyridoxal 5'-phosphate (PLP), relate to depression.
Our findings reveal that adults who consumed higher amounts of vitamin B6 or had elevated plasma PLP levels were less likely to experience symptoms of depression. Specifically, those in the top quartile for vitamin B6 intake had a significantly lower risk of depression compared to those in the lowest quartile. Similarly, higher PLP levels were associated with a reduced risk.
We noticed a clear trend: as both dietary intake of vitamin B6 and plasma PLP levels increased, the risk of depression decreased. However, it's important to note that while we found these associations, we cannot claim causation based on this study alone. This suggests that a balanced diet rich in vitamin B6 might be beneficial for mental health.
To fully understand the role of vitamin B6 in treating depression, we believe future randomized controlled trials should explore the potential effects of vitamin B6 supplementation.
Our findings reveal that adults who consumed higher amounts of vitamin B6 or had elevated plasma PLP levels were less likely to experience symptoms of depression. Specifically, those in the top quartile for vitamin B6 intake had a significantly lower risk of depression compared to those in the lowest quartile. Similarly, higher PLP levels were associated with a reduced risk.
We noticed a clear trend: as both dietary intake of vitamin B6 and plasma PLP levels increased, the risk of depression decreased. However, it's important to note that while we found these associations, we cannot claim causation based on this study alone. This suggests that a balanced diet rich in vitamin B6 might be beneficial for mental health.
To fully understand the role of vitamin B6 in treating depression, we believe future randomized controlled trials should explore the potential effects of vitamin B6 supplementation.
9.5
Potential depression aid
Most Useful Review
Methylfolate, or (6S)-5-MTHF, is the most effective form of folate, easily absorbed and critical for human health. It helps control homocysteine levels, supports cell growth, and reduces risks of developmental defects in infants. Methylfolate also positively influences cognitive functions, making it valuable for depression treatment. Studies show it can lower homocysteine levels, which, when elevated, is linked to cardiovascular diseases. It's crucial to choose methylfolate over standard folic acid, which is poorly absorbed and can hinder essential nutrient absorption from food.
L Carnosine
9.5
Depression relief
Most Useful Review
It works for depression! My depression has significantly reduced since I started taking it. The synergistic effect of combining it with supplements like B vitamins, vitamin C, vitamin E, and niacin has proven beneficial.
8.8
Mental enhancement
Most Useful Review
I find L-Carnosine to be an excellent dietary supplement and a powerful antioxidant, especially for those over 40. It lowers blood sugar, blood pressure, and enhances cardiovascular health. Furthermore, it boosts brain function and helps those experiencing chronic fatigue and depression. The product’s quality, packaging, and prompt delivery are commendable.
Ginkgo
9.5
Relieved panic attacks
Most Useful Review
I ordered this six months ago and take one capsule each morning. As someone who suffers from depression, I noticed my state stabilised, and panic attacks diminished after about a month and a half. I'm very satisfied and will order again. Thank you!
9.5
Reduced depressive symptoms
Most Useful Review
Ginkgo Biloba is a powerful antioxidant that enhances memory, concentration, and stabilises cardiovascular health. It improves blood circulation, reduces the risk of blood clots and heart issues, and helps alleviate symptoms of depression.
L Lysine
8.8
Mood improvement
Most Useful Review
Lysine is an essential amino acid that must be obtained from food or supplements. It aids athletes in muscle recovery, supports skin and hair health, and helps those prone to depression. It also assists the elderly in preventing osteoporosis and those suffering from herpes in mitigating symptoms.
9.5
Cold sore assistance
Most Useful Review
Lysine improves calcium absorption, restoring the body's normal state. It effectively relieves anxiety syndrome and alleviates depression harmlessly. Additionally, it is helpful for cold sores.
Potassium
9.5
Muscle pain relief
Most Useful Review
I found relief from muscle pain, fatigue, and depression after trying potassium. It helps maintain heart health, reduces the risk of stroke, and supports bones and muscles, amongst other benefits.
8.8
Postpartum relief
Most Useful Review
I recommend all mothers to use this after giving birth. The girls of Chavani often struggle with postpartum depression, and this helps restore their short-term memory, which can be lost due to depression. I advise combining copper, sodium, 10,000 IU vitamin D by Solgar, a vitamin B complex, magnesium, and Omega-rich supplements to alleviate anxiety and depression.
9.5
Essential for children
Most Useful Review
Echinacea is a vital addition to any medicine cabinet, especially for children. Its natural ingredients and sweet orange flavour appeal to kids while effectively strengthening their immune systems. This gentle stimulant is essential during cold seasons and helps them recover more swiftly from illnesses, including cases of depression.
9
Immunity booster
Most Useful Review
Echinacea is a potent natural immunity booster and is effective in treating and preventing respiratory diseases and depression. It aids in alleviating fatigue and supports the body during recovery periods, while also being beneficial in complex therapies for various ailments, including skin pathologies. Echinacea is especially useful for children to strengthen their immune systems, particularly those attending school.
Tumeric
8
Nanocurcumin shows antidepressant potential
Evaluation of Nanocurcumin Effects on Depressive-Like Behaviors in Rats and Determination of Serum BDNF and Serotonin Levels.
Most Relevant Research
We explored how nanocurcumin, a form of curcumin extracted from turmeric, influences depressive-like behaviors in rats subjected to chronic stress. Our research included 30 adult male rats, which were split into six groups to examine the effects of three different doses of nanocurcumin alongside a control group and a fluoxetine treatment group.
Before subjecting these rats to an unexpected chronic mild stress scenario, we measured their initial responses to a sweetened water consumption test to assess their baseline mood. Over the following days, we conducted thorough behavioral assessments using various tests designed to evaluate depressive symptoms, such as the open field test and the forced swimming test.
Ultimately, our findings revealed that nanocurcumin significantly improved moods in stressed rats by enhancing serotonin and brain-derived neurotrophic factor (BDNF) levels in their blood. This suggests that nanocurcumin may serve as an effective and promising alternative treatment option for major depressive disorder.
Before subjecting these rats to an unexpected chronic mild stress scenario, we measured their initial responses to a sweetened water consumption test to assess their baseline mood. Over the following days, we conducted thorough behavioral assessments using various tests designed to evaluate depressive symptoms, such as the open field test and the forced swimming test.
Ultimately, our findings revealed that nanocurcumin significantly improved moods in stressed rats by enhancing serotonin and brain-derived neurotrophic factor (BDNF) levels in their blood. This suggests that nanocurcumin may serve as an effective and promising alternative treatment option for major depressive disorder.
9.5
Fights depression effectively
Most Useful Review
Curcumin demonstrates powerful antioxidant properties that enhance heart health and may aid in preventing cancer. It also helps combat depression by blocking inflammatory signals. It has proven effective compared to some anti-inflammatory drugs in certain studies.
Evening Primrose
9.5
Natural remedy
Most Useful Review
Miracle oil! These capsules are a natural solution for many 'female' issues. They help normalise hormones and alleviate premenstrual syndrome, including abdominal pain and depression. They also enhance skin elasticity and support the immune system. I recommend these capsules to all women!
9.5
Hormonal balance
Most Useful Review
A wonderful natural remedy for various 'female' concerns! Evening primrose oil helps stabilise hormones and alleviates PMS symptoms like abdominal pain and depression. It also enhances skin elasticity and supports the immune response. I highly recommend these capsules!
Zinc
9
Zinc complex offers depression relief
Exploring Zn(II)-Acetyl l-carnitine complex for simultaneous management of depression, chronic pain, and neuroprotection.
Most Relevant Research
We investigated the potential benefits of a novel zinc complex, specifically Zn(ALC)Cl(HO), for its effectiveness in treating depression. This innovative compound combines zinc with acetyl-l-carnitine, which is known for its role in energy metabolism and protecting brain cells.
Our findings revealed that this zinc complex displays a remarkable 54% improvement in antidepressant activity compared to standard acetyl-l-carnitine. We also observed its ability to reduce pain in tests involving chronic conditions, showing promise in enhancing overall mental and physical health.
Additionally, this compound demonstrated capability to cross the blood-brain barrier, protecting against cell damage from excessive glutamate. We think these results indicate that Zn(ALC)Cl(HO) could be a significant step forward in managing not just depression but also neurodegenerative challenges.
Our findings revealed that this zinc complex displays a remarkable 54% improvement in antidepressant activity compared to standard acetyl-l-carnitine. We also observed its ability to reduce pain in tests involving chronic conditions, showing promise in enhancing overall mental and physical health.
Additionally, this compound demonstrated capability to cross the blood-brain barrier, protecting against cell damage from excessive glutamate. We think these results indicate that Zn(ALC)Cl(HO) could be a significant step forward in managing not just depression but also neurodegenerative challenges.
9.5
Improved mood
Most Useful Review
Very effective and easily digestible vitamins. After a month, it became easier to wake up, and the feelings of drowsiness and apathy vanished. My enthusiasm for living and working returned. I recommend this for those often experiencing depression and post-depression recovery.
Polygonum Cuspidatum Complex
7.5
Improves brain activity
Most Useful Review
I purchased this for my sister following her illness. Since using it, she has felt a surge of energy and cheerfulness. Resveratrol slows cellular aging, protects against depression, enhances cerebral blood flow, and improves memory.
9.5
Helps brain injury
Most Useful Review
I appreciate that this brand crosses the blood-brain barrier. Resveratrol benefits my brain injury, anxiety, depression, and energy levels significantly.
Coenzyme Q10
9
Q10 enhances mood in Alzheimer’s
Low-intensity pulsed ultrasound enhances delivery of 30 nm Q10 for improving mental and memory disorder in APP/PS1 mice.
Most Relevant Research
We explored the potential of coenzyme Q10 (Q10) in tackling mental and memory issues often faced by patients with Alzheimer's disease (AD). The study took a closer look at whether low-intensity pulsed ultrasound (LIPUS) could help in delivering a specially prepared 30 nm form of Q10 across the blood-brain barrier more effectively.
Through this research, we administered 30 nm Q10 to both wild-type mice and genetically modified APP/PS1 mice that model familial AD. We examined the effects of Q10 alone and in combination with LIPUS at two different intensities (50 and 100 mW/cm). What we discovered was intriguing: combining the higher intensity of LIPUS with 30 nm Q10 not only improved mood and reduced anxiety and depressive behaviors but also led to an increase in essential brain chemicals like serotonin and dopamine, while lowering harmful substances like formaldehyde.
However, it's important to note that even with these promising results, LIPUS alone did not completely eliminate symptoms of anxiety, depression, or memory deficits. While the combination therapy showed effectiveness in enhancing Q10 delivery and boosting some mood-related markers, further research is needed to refine these treatments for better overall outcomes in Alzheimer’s.
Through this research, we administered 30 nm Q10 to both wild-type mice and genetically modified APP/PS1 mice that model familial AD. We examined the effects of Q10 alone and in combination with LIPUS at two different intensities (50 and 100 mW/cm). What we discovered was intriguing: combining the higher intensity of LIPUS with 30 nm Q10 not only improved mood and reduced anxiety and depressive behaviors but also led to an increase in essential brain chemicals like serotonin and dopamine, while lowering harmful substances like formaldehyde.
However, it's important to note that even with these promising results, LIPUS alone did not completely eliminate symptoms of anxiety, depression, or memory deficits. While the combination therapy showed effectiveness in enhancing Q10 delivery and boosting some mood-related markers, further research is needed to refine these treatments for better overall outcomes in Alzheimer’s.
9
Supports depression relief
Most Useful Review
Coenzyme Q10 is vital for energy production and has notably improved my well-being. After noticing its benefits, including reduced fatigue and enhanced mood, I’ve encouraged others to try it. My mother, who leads an unhealthy lifestyle, experienced a significant uplift in her energy levels and mood after taking it. It's an essential support for heart health and an effective remedy for depression.
Vitamin D3
9.5
Cholecalciferol eases depression symptoms
Effects of cholecalciferol supplementation on depressive symptoms, C-peptide, serotonin, and neurotrophin-3 in type 2 diabetes mellitus: A double-blind, randomized, placebo-controlled trial.
Most Relevant Research
We conducted a thorough exploration of how vitamin D3, or cholecalciferol, affects depressive symptoms in patients with type 2 diabetes mellitus (T2DM). This double-blind, randomized, placebo-controlled trial involved 70 participants who experienced both T2DM and depression. For 12 weeks, one group received a daily dose of 4000 IU of cholecalciferol, while the other group received a placebo.
By assessing depression levels using the Beck Depression Inventory-II before and after the study, we observed notable results. Not only did the cholecalciferol group report a significant reduction in depression scores, but we found a marked increase in C-peptide levels as well, which may be linked to improvements in mood.
However, we did not find significant changes in serotonin and neurotrophin-3 levels between the two groups, leaving us with some unanswered questions about these mechanisms. Overall, our findings suggest that supplementing with cholecalciferol could potentially relieve mild to moderate depressive symptoms for people managing T2DM, especially through enhanced C-peptide levels.
By assessing depression levels using the Beck Depression Inventory-II before and after the study, we observed notable results. Not only did the cholecalciferol group report a significant reduction in depression scores, but we found a marked increase in C-peptide levels as well, which may be linked to improvements in mood.
However, we did not find significant changes in serotonin and neurotrophin-3 levels between the two groups, leaving us with some unanswered questions about these mechanisms. Overall, our findings suggest that supplementing with cholecalciferol could potentially relieve mild to moderate depressive symptoms for people managing T2DM, especially through enhanced C-peptide levels.
9.5
Boosted immunity
Most Useful Review
Good afternoon! These Vitamin D3 capsules are fantastic for boosting immunity in a digestible liquid form. Living in Siberia, we suffer from vitamin D deficiency. We've noticed a positive effect during the ARVI season, as we fell ill less frequently and more mildly. The whole family takes it, and I’ve been on this dosage for over a year. It helps alleviate depression due to the lack of sun, increases vitality, and without it in the morning, I don't feel like myself.
Eicosapentaenoic Acid
4
EPA shows potential in depression
Exploration of the optimized portrait of omega-3 polyunsaturated fatty acids in treating depression: A meta-analysis of randomized-controlled trials.
Most Relevant Research
We examined the effectiveness of eicosapentaenoic acid (EPA), a type of omega-3 polyunsaturated fatty acid, in treating depression. After analyzing 36 well-structured studies, we found some positive outcomes and also observed notable variability in the results. The overall findings suggested that EPA could offer benefits for depression, yielding a small but statistically significant improvement in symptoms.
It's particularly interesting to note that for Asian patients experiencing mild to moderate depression, the best results seemed to emerge with a daily dosage of 1000 to 1500 mg of omega-3s over eight weeks. This intake should ideally have a specific balance of EPA to another omega-3, docosahexaenoic acid (DHA), set at between 1:1 and 2:1 ratios. However, despite these encouraging indications, our analysis also revealed that EPA isn’t better than a placebo for achieving response or remission rates or for adverse events.
Overall, while omega-3 PUFAs like EPA may hold promise for managing depressive symptoms, we must approach the findings with caution. Further research is warranted to deepen our understanding of how to harness the potential benefits of these fatty acids in treating depression.
It's particularly interesting to note that for Asian patients experiencing mild to moderate depression, the best results seemed to emerge with a daily dosage of 1000 to 1500 mg of omega-3s over eight weeks. This intake should ideally have a specific balance of EPA to another omega-3, docosahexaenoic acid (DHA), set at between 1:1 and 2:1 ratios. However, despite these encouraging indications, our analysis also revealed that EPA isn’t better than a placebo for achieving response or remission rates or for adverse events.
Overall, while omega-3 PUFAs like EPA may hold promise for managing depressive symptoms, we must approach the findings with caution. Further research is warranted to deepen our understanding of how to harness the potential benefits of these fatty acids in treating depression.
9.5
Mood improvement
Most Useful Review
I have tried numerous omega brands and this one is by far my favourite. If you take 2 capsules daily, it lasts two months, which is quite economical. I experience a light citrus burp instead of fishy, which is a plus. It has improved my hair and nails and helped my post-Covid depression significantly. The packaging is excellent and the capsules, though large and straw-yellow, are easy to swallow. Drinking omega is advisable for everyone, as it truly enhances health and mood.
L Theanine
8
Inositol's role in depression unclear
Comparative Efficacy of Omega-3 Fatty Acid with Other Interventions for Depression in Children and Adolescents: A Systematic Review and Network Meta-Analysis.
Most Relevant Research
We explored the role of inositol in alleviating depression among children and adolescents. This systematic review gathered data from nine studies involving 561 participants, focusing on the effectiveness of omega-3 fatty acids alongside inositol in combating depressive symptoms.
Our analysis found that while inositol is often included with omega-3 in combination therapies, its isolated effect on depression could not be clearly established. The results indicated that when omega-3 is combined with inositol, it showed promising efficacy, acting as a potential support for traditional therapies.
However, we noted that there was no significant improvement in depression symptoms compared to placebo treatments when evaluating these interventions individually. Ultimately, omega-3 paired with psychoeducational psychotherapy emerged as the most effective approach, but the impact of inositol on its own remains inconclusive.
These findings suggest a need for future studies to assess inositol individually, helping us better understand its potential in managing depression.
Our analysis found that while inositol is often included with omega-3 in combination therapies, its isolated effect on depression could not be clearly established. The results indicated that when omega-3 is combined with inositol, it showed promising efficacy, acting as a potential support for traditional therapies.
However, we noted that there was no significant improvement in depression symptoms compared to placebo treatments when evaluating these interventions individually. Ultimately, omega-3 paired with psychoeducational psychotherapy emerged as the most effective approach, but the impact of inositol on its own remains inconclusive.
These findings suggest a need for future studies to assess inositol individually, helping us better understand its potential in managing depression.
10
Alleviated anxiety
Most Useful Review
I developed anxiety and depression, leading to unclear thoughts and emotional eating. This supplement transformed my well-being. I now feel like my old self, with reduced anxiety and improved focus, enabling me to manage stress calmly. It has significantly improved my sleep and overall mood.
Iron
7
Exploration of Nutrient Effects
Four-way decomposition of the effects of nutrient supplement and physical exercise on depression among older Chinese: a nationwide cross-sectional analysis.
Most Relevant Research
We studied how nutrient supplements, particularly iron, and physical exercise influence depression among older adults in China. Our analysis included 8,427 participants, and we used established tools to measure depression and collect information about their supplement and exercise habits.
Interestingly, we found that 26.2% of the older adults reported suffering from depression. Among the various nutrients studied, we discovered that receiving nutrient supplements, like calcium and multivitamins, was linked to lower depression scores and reduced risk of depression. However, the effects of iron alone could not be isolated due to the combination with other nutrients in the supplements.
Our analysis revealed that physical exercise played a role in mediating the relationship between certain nutrients and depression. This means that for some participants, staying active could enhance the positive effects of nutrient supplementation on their mood. Nevertheless, it is essential to note that there wasn't enough evidence to conclusively state that iron specifically improves depression despite being part of the nutrient mix explored.
Interestingly, we found that 26.2% of the older adults reported suffering from depression. Among the various nutrients studied, we discovered that receiving nutrient supplements, like calcium and multivitamins, was linked to lower depression scores and reduced risk of depression. However, the effects of iron alone could not be isolated due to the combination with other nutrients in the supplements.
Our analysis revealed that physical exercise played a role in mediating the relationship between certain nutrients and depression. This means that for some participants, staying active could enhance the positive effects of nutrient supplementation on their mood. Nevertheless, it is essential to note that there wasn't enough evidence to conclusively state that iron specifically improves depression despite being part of the nutrient mix explored.
8.8
Improved mood
Most Useful Review
I've been using this vitamin for a few months and my overall well-being has noticeably improved. My mood has enhanced, making it an excellent supplement for those who struggle with depression, as it offers varied health benefits, providing good value for money.
Docosahexaenoic Acid
5
Investigating DHA’s depression treatment
Exploration of the optimized portrait of omega-3 polyunsaturated fatty acids in treating depression: A meta-analysis of randomized-controlled trials.
Most Relevant Research
We explored the effectiveness of omega-3 polyunsaturated fatty acids (PUFAs), particularly docosahexaenoic acid (DHA), in treating depression through a meta-analysis of randomized controlled trials. Our investigation included extensive data from 36 studies, offering a comprehensive look at how these fatty acids might influence mental health.
While we found some significant evidence suggesting that omega-3 PUFAs, in general, could be beneficial for people suffering from depression, the specific impact of DHA alone was not isolated. It turned out that there's no stronger effect from omega-3 PUFAs compared to a placebo in terms of response rates, remission, or adverse events. Interestingly, we noted that patients from Asia who experienced mild to moderate depression and took DHA over a period of eight weeks might fare the best if their daily dosage ranged from 1000 to 1500 mg, maintaining a specific ratio of eicosapentaenoic acid (EPA) to DHA.
Overall, we observed that while omega-3s may provide some benefits in treating depression, they do not show superior results compared to a placebo group. This highlights the importance of understanding not just the broader category of omega-3s, but the nuanced roles of individual components like DHA.
While we found some significant evidence suggesting that omega-3 PUFAs, in general, could be beneficial for people suffering from depression, the specific impact of DHA alone was not isolated. It turned out that there's no stronger effect from omega-3 PUFAs compared to a placebo in terms of response rates, remission, or adverse events. Interestingly, we noted that patients from Asia who experienced mild to moderate depression and took DHA over a period of eight weeks might fare the best if their daily dosage ranged from 1000 to 1500 mg, maintaining a specific ratio of eicosapentaenoic acid (EPA) to DHA.
Overall, we observed that while omega-3s may provide some benefits in treating depression, they do not show superior results compared to a placebo group. This highlights the importance of understanding not just the broader category of omega-3s, but the nuanced roles of individual components like DHA.
9.5
Alleviates depression
Most Useful Review
I began taking this vegan DHA during my pregnancy, and I’ve continued as it significantly alleviates my depression. I've tried other brands, but none have worked as effectively as Deva.
Fish Oil
4
EPA shows potential in depression
Exploration of the optimized portrait of omega-3 polyunsaturated fatty acids in treating depression: A meta-analysis of randomized-controlled trials.
Most Relevant Research
We examined the effectiveness of eicosapentaenoic acid (EPA), a type of omega-3 polyunsaturated fatty acid, in treating depression. After analyzing 36 well-structured studies, we found some positive outcomes and also observed notable variability in the results. The overall findings suggested that EPA could offer benefits for depression, yielding a small but statistically significant improvement in symptoms.
It's particularly interesting to note that for Asian patients experiencing mild to moderate depression, the best results seemed to emerge with a daily dosage of 1000 to 1500 mg of omega-3s over eight weeks. This intake should ideally have a specific balance of EPA to another omega-3, docosahexaenoic acid (DHA), set at between 1:1 and 2:1 ratios. However, despite these encouraging indications, our analysis also revealed that EPA isn’t better than a placebo for achieving response or remission rates or for adverse events.
Overall, while omega-3 PUFAs like EPA may hold promise for managing depressive symptoms, we must approach the findings with caution. Further research is warranted to deepen our understanding of how to harness the potential benefits of these fatty acids in treating depression.
It's particularly interesting to note that for Asian patients experiencing mild to moderate depression, the best results seemed to emerge with a daily dosage of 1000 to 1500 mg of omega-3s over eight weeks. This intake should ideally have a specific balance of EPA to another omega-3, docosahexaenoic acid (DHA), set at between 1:1 and 2:1 ratios. However, despite these encouraging indications, our analysis also revealed that EPA isn’t better than a placebo for achieving response or remission rates or for adverse events.
Overall, while omega-3 PUFAs like EPA may hold promise for managing depressive symptoms, we must approach the findings with caution. Further research is warranted to deepen our understanding of how to harness the potential benefits of these fatty acids in treating depression.
9.5
Improved skin condition
Most Useful Review
Omega-3 fatty acids are essential and must be obtained from food or supplements, as the body cannot produce them. They help manage depression and improve skin health. Many individuals with conditions like eczema find their skin improves with Omega-3 intake. I noticed better sleep and increased energy levels after taking Omega from NOW FOODS. It offers a great price-to-quality ratio with 200 capsules lasting for three months.
Vitamin B12
7
Valeriana jatamansi and depression study
Valeriana jatamansi jones improves depressive behavior in CUMS mice by modulating vitamin B12-related ileal homeostasis.
Most Relevant Research
We investigated how Valeriana jatamansi, a traditional herbal remedy, might aid in alleviating symptoms of depression by affecting vitamin B12 levels in the body. Using a mouse model subjected to chronic unpredictable mild stress, we observed how V. jatamansi extracts impacted behavior related to depression.
Over five weeks, we induced depressive-like behaviors in the mice and subsequently treated them with V. jatamansi for three weeks. Upon evaluation through various behavioral tests, we found that the extracts appeared to improve their mood. More importantly, we noted that these benefits were associated with positive changes in the mice's ileal health and functionality related to vitamin B12 absorption.
Our findings suggest that V. jatamansi may help repair damage in the intestines that can accompany depression. This could enhance the body's ability to absorb vitamin B12, ultimately reducing levels of homocysteine—a compound that can negatively affect the brain. By addressing these elements, we can see how vitamin B12 might play a supportive role in treating depression, even if it forms part of a larger treatment approach involving herbal remedies like V. jatamansi.
Over five weeks, we induced depressive-like behaviors in the mice and subsequently treated them with V. jatamansi for three weeks. Upon evaluation through various behavioral tests, we found that the extracts appeared to improve their mood. More importantly, we noted that these benefits were associated with positive changes in the mice's ileal health and functionality related to vitamin B12 absorption.
Our findings suggest that V. jatamansi may help repair damage in the intestines that can accompany depression. This could enhance the body's ability to absorb vitamin B12, ultimately reducing levels of homocysteine—a compound that can negatively affect the brain. By addressing these elements, we can see how vitamin B12 might play a supportive role in treating depression, even if it forms part of a larger treatment approach involving herbal remedies like V. jatamansi.
9.5
Improved mood
Most Useful Review
Amazing B12! This supplement has made a massive difference to my energy levels and mood swings. After taking it alongside a B-complex for just three days, I felt fantastic. I've struggled with severe depression for years, but these two supplements truly work for me. I take them with a fruit smoothie in the morning, and I can’t recommend them enough; simply awesome!
Omega 3
4
EPA shows potential in depression
Exploration of the optimized portrait of omega-3 polyunsaturated fatty acids in treating depression: A meta-analysis of randomized-controlled trials.
Most Relevant Research
We examined the effectiveness of eicosapentaenoic acid (EPA), a type of omega-3 polyunsaturated fatty acid, in treating depression. After analyzing 36 well-structured studies, we found some positive outcomes and also observed notable variability in the results. The overall findings suggested that EPA could offer benefits for depression, yielding a small but statistically significant improvement in symptoms.
It's particularly interesting to note that for Asian patients experiencing mild to moderate depression, the best results seemed to emerge with a daily dosage of 1000 to 1500 mg of omega-3s over eight weeks. This intake should ideally have a specific balance of EPA to another omega-3, docosahexaenoic acid (DHA), set at between 1:1 and 2:1 ratios. However, despite these encouraging indications, our analysis also revealed that EPA isn’t better than a placebo for achieving response or remission rates or for adverse events.
Overall, while omega-3 PUFAs like EPA may hold promise for managing depressive symptoms, we must approach the findings with caution. Further research is warranted to deepen our understanding of how to harness the potential benefits of these fatty acids in treating depression.
It's particularly interesting to note that for Asian patients experiencing mild to moderate depression, the best results seemed to emerge with a daily dosage of 1000 to 1500 mg of omega-3s over eight weeks. This intake should ideally have a specific balance of EPA to another omega-3, docosahexaenoic acid (DHA), set at between 1:1 and 2:1 ratios. However, despite these encouraging indications, our analysis also revealed that EPA isn’t better than a placebo for achieving response or remission rates or for adverse events.
Overall, while omega-3 PUFAs like EPA may hold promise for managing depressive symptoms, we must approach the findings with caution. Further research is warranted to deepen our understanding of how to harness the potential benefits of these fatty acids in treating depression.
9.5
Depression relief
Most Useful Review
This brand of fish oil has helped lift my permanent depression. There's no unpleasant fish taste or odour, and it works well compared to other Omega-3 brands I've tried.
Calcium
7
Calcium's role in depression explored
Assessment of the Correlation Between Unipolar and Bipolar Depression, Calcium Levels, Thyroid Function, and Inflammatory Markers: A Pilot Cross-Sectional Study.
Most Relevant Research
We aimed to investigate the connection between calcium levels and depression, specifically comparing unipolar and bipolar disorders. In the course of our pilot study, we enrolled 36 patients admitted to the University of Insubria Psychiatric Unit, who completed various psychological assessments to gauge their mental health.
Our findings revealed a noteworthy association between calcium levels and bipolar depression. We observed significant correlations not only between calcium and depressive symptoms, but also with inflammation markers like CRP (C-reactive protein). This indicates a possible relationship where lower calcium levels may relate to more severe symptoms in individuals with bipolar disorder.
While these associations are intriguing, it's important to note that we did not isolate the effects of calcium treatment itself on depressive symptoms. Therefore, while our results push the conversation forward regarding the role of calcium in mental health, they do not establish that calcium treatment is definitively beneficial for those struggling with depression.
Further research is essential to deepen our understanding of how inflammatory markers like calcium may contribute to different forms of depression. Our study highlights a pathway for future exploration into targeted therapeutic strategies that could help in treating these complex mood disorders more effectively.
Our findings revealed a noteworthy association between calcium levels and bipolar depression. We observed significant correlations not only between calcium and depressive symptoms, but also with inflammation markers like CRP (C-reactive protein). This indicates a possible relationship where lower calcium levels may relate to more severe symptoms in individuals with bipolar disorder.
While these associations are intriguing, it's important to note that we did not isolate the effects of calcium treatment itself on depressive symptoms. Therefore, while our results push the conversation forward regarding the role of calcium in mental health, they do not establish that calcium treatment is definitively beneficial for those struggling with depression.
Further research is essential to deepen our understanding of how inflammatory markers like calcium may contribute to different forms of depression. Our study highlights a pathway for future exploration into targeted therapeutic strategies that could help in treating these complex mood disorders more effectively.
9.5
Calmness achieved
Most Useful Review
Calm improved! I began to feel much calmer, with no signs of depression. My husband is surprised by my reduced yelling. I highly recommend it.