 NOW Foods, Glutathione, 500 mg, 60 Veg Capsules | | |
Silibinin reduces depression in miceSilibinin ameliorates depression/anxiety-like behaviors of Parkinson's disease mouse model and is associated with attenuated STING-IRF3-IFN-β pathway activation and neuroinflammation. We investigated the impact of silibinin, a natural compound from Silybum marianum, on depression and anxiety in mice with Parkinson's disease. Through various behavioral tests, we found that silibinin significantly reduced depressive and anxious behaviors caused by MPTP, a chemical used to induce these symptoms.
Additionally, silibinin helped repair neuronal damage in the hippocampus and restored levels of important mood-regulating neurotransmitters. It also reduced markers of neuroinflammation linked to depression, suggesting silibinin may hold promise as a treatment for these conditions in Parkinson's. Essential support Most Useful Review 2 people found this helpful Glutathione, a combination of cysteine, glycine, and glutamine, is effective when taken on an empty stomach, especially after covid or during episodes of spring blues and depression. It really supported me, and by the third day, I felt an extraordinary surge of energy throughout my body! |
 Solgar, Zinc, 50 mg, 100 Tablets | | |
Zinc deficiency impacts brain functionProteomics analysis in rats reveals convergent mechanisms between major depressive disorder and dietary zinc deficiency. We aimed to uncover the connection between dietary zinc deficiency and symptoms associated with major depressive disorder (MDD). In our study, we used rats fed either a zinc-adequate diet or one deficient in zinc for four weeks.
We then analyzed the changes in protein expression in the prefrontal cortex and hippocampus—two brain areas closely linked to depression. This approach allowed us to see how zinc deficiency impacts the brain at a molecular level.
Our findings revealed that significant alterations occurred in proteins related to zinc transport and mitochondrial function due to the deficiency. In particular, we saw a notable decline in the activity of complex I of the mitochondrial energy production pathway in the prefrontal cortex.
These results suggest that low zinc levels can disrupt vital brain functions, potentially contributing to the development of depressive symptoms. This highlights the importance of maintaining adequate zinc levels for mental health. Improved mood Most Useful Review 309 people found this helpful Very effective and easily digestible vitamins. After a month, it became easier to wake up, and the feelings of drowsiness and apathy vanished. My enthusiasm for living and working returned. I recommend this for those often experiencing depression and post-depression recovery. |
 Nature's Way, Zinc Chelate, 30 mg, 100 Capsules | | |
Zinc deficiency impacts brain functionProteomics analysis in rats reveals convergent mechanisms between major depressive disorder and dietary zinc deficiency. We aimed to uncover the connection between dietary zinc deficiency and symptoms associated with major depressive disorder (MDD). In our study, we used rats fed either a zinc-adequate diet or one deficient in zinc for four weeks.
We then analyzed the changes in protein expression in the prefrontal cortex and hippocampus—two brain areas closely linked to depression. This approach allowed us to see how zinc deficiency impacts the brain at a molecular level.
Our findings revealed that significant alterations occurred in proteins related to zinc transport and mitochondrial function due to the deficiency. In particular, we saw a notable decline in the activity of complex I of the mitochondrial energy production pathway in the prefrontal cortex.
These results suggest that low zinc levels can disrupt vital brain functions, potentially contributing to the development of depressive symptoms. This highlights the importance of maintaining adequate zinc levels for mental health. Improved mental health Most Useful Review 102 people found this helpful This vitamin has significantly aided my battle with depression and anxiety over the past year. Taking it consistently has made an enormous difference. I highly recommend it to anyone struggling with their mental health or not feeling their best. |
 Garden of Life, Vitamin Code, RAW Zinc, 60 Vegan Capsules | | |
Zinc deficiency impacts brain functionProteomics analysis in rats reveals convergent mechanisms between major depressive disorder and dietary zinc deficiency. We aimed to uncover the connection between dietary zinc deficiency and symptoms associated with major depressive disorder (MDD). In our study, we used rats fed either a zinc-adequate diet or one deficient in zinc for four weeks.
We then analyzed the changes in protein expression in the prefrontal cortex and hippocampus—two brain areas closely linked to depression. This approach allowed us to see how zinc deficiency impacts the brain at a molecular level.
Our findings revealed that significant alterations occurred in proteins related to zinc transport and mitochondrial function due to the deficiency. In particular, we saw a notable decline in the activity of complex I of the mitochondrial energy production pathway in the prefrontal cortex.
These results suggest that low zinc levels can disrupt vital brain functions, potentially contributing to the development of depressive symptoms. This highlights the importance of maintaining adequate zinc levels for mental health. Improved mood Most Useful Review 5 people found this helpful Miracle remedy. I got it because the cosmetologist advised me to take zinc for my skin. At 46, I suffer from acne and a dry face. This zinc is just miraculous. The rashes disappeared completely, and my skin became nourished, soft and moisturised. Zinc evens out my complexion. Additionally, my hormonal balance normalised, sleep improved, and depression disappeared. I feel always smooth, calm, and harmonious. I recommend it. I take 2 capsules after a meal and have ordered two more packs. |
 NOW Foods, L-OptiZinc, 30 mg, 100 Veg Capsules | | |
Zinc deficiency impacts brain functionProteomics analysis in rats reveals convergent mechanisms between major depressive disorder and dietary zinc deficiency. We aimed to uncover the connection between dietary zinc deficiency and symptoms associated with major depressive disorder (MDD). In our study, we used rats fed either a zinc-adequate diet or one deficient in zinc for four weeks.
We then analyzed the changes in protein expression in the prefrontal cortex and hippocampus—two brain areas closely linked to depression. This approach allowed us to see how zinc deficiency impacts the brain at a molecular level.
Our findings revealed that significant alterations occurred in proteins related to zinc transport and mitochondrial function due to the deficiency. In particular, we saw a notable decline in the activity of complex I of the mitochondrial energy production pathway in the prefrontal cortex.
These results suggest that low zinc levels can disrupt vital brain functions, potentially contributing to the development of depressive symptoms. This highlights the importance of maintaining adequate zinc levels for mental health. Improved sleep quality Most Useful Review Excellent! The positive effects include better sleep and the alleviation of depression symptoms. While I feel nauseous, I understand that's due to the zinc rather than the brand. What matters is that it's benefitting me, confirming its quality. I liked it. |
 Solgar, Chelated Zinc, 22 mg, 250 Tablets | | |
Zinc deficiency impacts brain functionProteomics analysis in rats reveals convergent mechanisms between major depressive disorder and dietary zinc deficiency. We aimed to uncover the connection between dietary zinc deficiency and symptoms associated with major depressive disorder (MDD). In our study, we used rats fed either a zinc-adequate diet or one deficient in zinc for four weeks.
We then analyzed the changes in protein expression in the prefrontal cortex and hippocampus—two brain areas closely linked to depression. This approach allowed us to see how zinc deficiency impacts the brain at a molecular level.
Our findings revealed that significant alterations occurred in proteins related to zinc transport and mitochondrial function due to the deficiency. In particular, we saw a notable decline in the activity of complex I of the mitochondrial energy production pathway in the prefrontal cortex.
These results suggest that low zinc levels can disrupt vital brain functions, potentially contributing to the development of depressive symptoms. This highlights the importance of maintaining adequate zinc levels for mental health. Recommended for depression Most Useful Review 8 people found this helpful I really like this product! I would definitely recommend purchasing it. The company doesn’t need marketing as it effectively saves me from depression! If my review has been helpful, please give it a thumbs up. I would appreciate it! Also, for a discount of 5-10% on your order, visit my profile for a reusable promotional code! |
 Solgar, Zinc Picolinate, 22 mg, 100 Tablets | | |
Zinc deficiency impacts brain functionProteomics analysis in rats reveals convergent mechanisms between major depressive disorder and dietary zinc deficiency. We aimed to uncover the connection between dietary zinc deficiency and symptoms associated with major depressive disorder (MDD). In our study, we used rats fed either a zinc-adequate diet or one deficient in zinc for four weeks.
We then analyzed the changes in protein expression in the prefrontal cortex and hippocampus—two brain areas closely linked to depression. This approach allowed us to see how zinc deficiency impacts the brain at a molecular level.
Our findings revealed that significant alterations occurred in proteins related to zinc transport and mitochondrial function due to the deficiency. In particular, we saw a notable decline in the activity of complex I of the mitochondrial energy production pathway in the prefrontal cortex.
These results suggest that low zinc levels can disrupt vital brain functions, potentially contributing to the development of depressive symptoms. This highlights the importance of maintaining adequate zinc levels for mental health. Positive effects Most Useful Review Only a positive response to this supplement. I use zinc to assist with depression due to low levels in my tests. Solgar vitamins are always of high quality, so I continue to buy them. |
 Nature's Bounty, Zinc, 50 mg, 100 Tablets | | |
Zinc deficiency impacts brain functionProteomics analysis in rats reveals convergent mechanisms between major depressive disorder and dietary zinc deficiency. We aimed to uncover the connection between dietary zinc deficiency and symptoms associated with major depressive disorder (MDD). In our study, we used rats fed either a zinc-adequate diet or one deficient in zinc for four weeks.
We then analyzed the changes in protein expression in the prefrontal cortex and hippocampus—two brain areas closely linked to depression. This approach allowed us to see how zinc deficiency impacts the brain at a molecular level.
Our findings revealed that significant alterations occurred in proteins related to zinc transport and mitochondrial function due to the deficiency. In particular, we saw a notable decline in the activity of complex I of the mitochondrial energy production pathway in the prefrontal cortex.
These results suggest that low zinc levels can disrupt vital brain functions, potentially contributing to the development of depressive symptoms. This highlights the importance of maintaining adequate zinc levels for mental health. Reduces depression effectively Most Useful Review Definitely a necessary addition! I've used this supplement for a long time, three times a year for 30 days with great results. It boosts mood and memory, alleviates depression and anxiety, reduces the formation of fatty plaques, strengthens the immune system, and regulates glucose metabolism. It's an antioxidant that protects cells and aids growth and development during puberty. For men, it governs testosterone formation, improves sperm motility, and supports prostate health, while in women, it is vital for ovulation, menstrual regularity, and breastfeeding. |
 NOW Foods, Zinc Glycinate, 120 Softgels | | |
Zinc deficiency impacts brain functionProteomics analysis in rats reveals convergent mechanisms between major depressive disorder and dietary zinc deficiency. We aimed to uncover the connection between dietary zinc deficiency and symptoms associated with major depressive disorder (MDD). In our study, we used rats fed either a zinc-adequate diet or one deficient in zinc for four weeks.
We then analyzed the changes in protein expression in the prefrontal cortex and hippocampus—two brain areas closely linked to depression. This approach allowed us to see how zinc deficiency impacts the brain at a molecular level.
Our findings revealed that significant alterations occurred in proteins related to zinc transport and mitochondrial function due to the deficiency. In particular, we saw a notable decline in the activity of complex I of the mitochondrial energy production pathway in the prefrontal cortex.
These results suggest that low zinc levels can disrupt vital brain functions, potentially contributing to the development of depressive symptoms. This highlights the importance of maintaining adequate zinc levels for mental health. Improved condition Most Useful Review 4 people found this helpful It initially seemed easy to feel depressed, but after taking zinc regularly, my condition improved significantly. While I had some emotional instability before my period, taking zinc daily has helped alleviate my pre-menstrual mental symptoms greatly. I appreciate that these supplements are smaller and easier to take than many overseas products. |
 NOW Foods, Zinc Picolinate, 50 mg, 120 Veg Capsules | | |
Zinc deficiency impacts brain functionProteomics analysis in rats reveals convergent mechanisms between major depressive disorder and dietary zinc deficiency. We aimed to uncover the connection between dietary zinc deficiency and symptoms associated with major depressive disorder (MDD). In our study, we used rats fed either a zinc-adequate diet or one deficient in zinc for four weeks.
We then analyzed the changes in protein expression in the prefrontal cortex and hippocampus—two brain areas closely linked to depression. This approach allowed us to see how zinc deficiency impacts the brain at a molecular level.
Our findings revealed that significant alterations occurred in proteins related to zinc transport and mitochondrial function due to the deficiency. In particular, we saw a notable decline in the activity of complex I of the mitochondrial energy production pathway in the prefrontal cortex.
These results suggest that low zinc levels can disrupt vital brain functions, potentially contributing to the development of depressive symptoms. This highlights the importance of maintaining adequate zinc levels for mental health. Improves mood Most Useful Review 2 people found this helpful I've been taking zinc picolinate for several months as a preventive measure against depression. It has helped me manage my anxiety and irritability due to stress, leaving me feeling calmer, more confident, and productive. |
 Life Extension, Zinc Caps, High Potency, 50 mg, 90 Vegetarian Capsules | | |
Zinc deficiency impacts brain functionProteomics analysis in rats reveals convergent mechanisms between major depressive disorder and dietary zinc deficiency. We aimed to uncover the connection between dietary zinc deficiency and symptoms associated with major depressive disorder (MDD). In our study, we used rats fed either a zinc-adequate diet or one deficient in zinc for four weeks.
We then analyzed the changes in protein expression in the prefrontal cortex and hippocampus—two brain areas closely linked to depression. This approach allowed us to see how zinc deficiency impacts the brain at a molecular level.
Our findings revealed that significant alterations occurred in proteins related to zinc transport and mitochondrial function due to the deficiency. In particular, we saw a notable decline in the activity of complex I of the mitochondrial energy production pathway in the prefrontal cortex.
These results suggest that low zinc levels can disrupt vital brain functions, potentially contributing to the development of depressive symptoms. This highlights the importance of maintaining adequate zinc levels for mental health. Reduced fatigue Most Useful Review 14 people found this helpful This supplement has been effective for everyday fatigue, depression, and lack of energy from withdrawal symptoms of sleeping pills. My family suffers from insomnia due to such symptoms, and I found that adding zinc improved my overall condition, including decreasing irritability. |
 NOW Foods, Zinc, 50 mg, 250 Tablets | | |
Zinc deficiency impacts brain functionProteomics analysis in rats reveals convergent mechanisms between major depressive disorder and dietary zinc deficiency. We aimed to uncover the connection between dietary zinc deficiency and symptoms associated with major depressive disorder (MDD). In our study, we used rats fed either a zinc-adequate diet or one deficient in zinc for four weeks.
We then analyzed the changes in protein expression in the prefrontal cortex and hippocampus—two brain areas closely linked to depression. This approach allowed us to see how zinc deficiency impacts the brain at a molecular level.
Our findings revealed that significant alterations occurred in proteins related to zinc transport and mitochondrial function due to the deficiency. In particular, we saw a notable decline in the activity of complex I of the mitochondrial energy production pathway in the prefrontal cortex.
These results suggest that low zinc levels can disrupt vital brain functions, potentially contributing to the development of depressive symptoms. This highlights the importance of maintaining adequate zinc levels for mental health. Combats winter depression Most Useful Review To combat winter depression, I started taking it with Vitamin D, and I'm pleasantly surprised by the results. It has significantly improved my mood and energy levels during these colder months, making daily life much more manageable. |
 NOW Foods, Sustained Release B-100, 100 Tablets | | |
Vitamin B may alleviate depression symptoms[Effects of Vitamin B on Behaviors, Brain Monoamine Neurotransmitters, and Brain-Derived Neurotrophic Factor in Depressive Rats]. Our investigation looked into how Vitamin B affects behavior and neurotransmitter levels in rats undergoing stress-induced depression.
We set up three groups: a control group, a stressed group, and a stressed group receiving Vitamin B.
The results showed that Vitamin B improved neurotransmitter levels and reduced anxiety and depression-like behaviors in the rats. This suggests that Vitamin B could be beneficial in improving symptoms of depression driven by stress. Struggles with depression Most Useful Review 1 people found this helpful The battle against chronic and seasonal depression can be overwhelming, especially when faced with these yellow supplements. |
 21st Century, B-100 Complex, Prolonged Release, 60 Tablets | | |
Vitamin B may alleviate depression symptoms[Effects of Vitamin B on Behaviors, Brain Monoamine Neurotransmitters, and Brain-Derived Neurotrophic Factor in Depressive Rats]. Our investigation looked into how Vitamin B affects behavior and neurotransmitter levels in rats undergoing stress-induced depression.
We set up three groups: a control group, a stressed group, and a stressed group receiving Vitamin B.
The results showed that Vitamin B improved neurotransmitter levels and reduced anxiety and depression-like behaviors in the rats. This suggests that Vitamin B could be beneficial in improving symptoms of depression driven by stress. Alleviated symptoms Most Useful Review 31 people found this helpful I use it to relieve depression. I was feeling quite unwell when I discovered the impact of B vitamins online, prompting me to start taking them. As they are water-soluble, I noticed their effect relatively quickly. I believe the symptom has improved. If this is beneficial for you, I hope you appreciate it. Thank you. |
 NOW Foods, B-50, 100 Veg Capsules | | |
Vitamin B may alleviate depression symptoms[Effects of Vitamin B on Behaviors, Brain Monoamine Neurotransmitters, and Brain-Derived Neurotrophic Factor in Depressive Rats]. Our investigation looked into how Vitamin B affects behavior and neurotransmitter levels in rats undergoing stress-induced depression.
We set up three groups: a control group, a stressed group, and a stressed group receiving Vitamin B.
The results showed that Vitamin B improved neurotransmitter levels and reduced anxiety and depression-like behaviors in the rats. This suggests that Vitamin B could be beneficial in improving symptoms of depression driven by stress. Mood improvement Most Useful Review 447 people found this helpful The whole B-complex is contained in one capsule. I have noticed real results: Despite dreary, rainy weather, I feel cheerful. This year, the usual autumn depression has not affected me. I respond calmly to work stress, viewing it as part of life. My skin is managing well through the autumn-winter transition, free from dryness and tightness. My joints are also not causing issues. |
 Jarrow Formulas, B-Right, 100 Veggie Capsules | | |
Vitamin B may alleviate depression symptoms[Effects of Vitamin B on Behaviors, Brain Monoamine Neurotransmitters, and Brain-Derived Neurotrophic Factor in Depressive Rats]. Our investigation looked into how Vitamin B affects behavior and neurotransmitter levels in rats undergoing stress-induced depression.
We set up three groups: a control group, a stressed group, and a stressed group receiving Vitamin B.
The results showed that Vitamin B improved neurotransmitter levels and reduced anxiety and depression-like behaviors in the rats. This suggests that Vitamin B could be beneficial in improving symptoms of depression driven by stress. Helps with depression Most Useful Review 3 people found this helpful Seems to be working! Last week I noticed I was feeling unusually down for no apparent reason. I hadn’t felt this way for the past month or two, ever since I started taking B-Right along with several other vitamins and herbs. Upon realising that I had misplaced B-Right and missed taking it for a few days, I resumed taking it and haven’t felt that depression for almost a week now. |
 Solgar, B-Complex "100", 250 Vegetable Capsules | | |
Vitamin B may alleviate depression symptoms[Effects of Vitamin B on Behaviors, Brain Monoamine Neurotransmitters, and Brain-Derived Neurotrophic Factor in Depressive Rats]. Our investigation looked into how Vitamin B affects behavior and neurotransmitter levels in rats undergoing stress-induced depression.
We set up three groups: a control group, a stressed group, and a stressed group receiving Vitamin B.
The results showed that Vitamin B improved neurotransmitter levels and reduced anxiety and depression-like behaviors in the rats. This suggests that Vitamin B could be beneficial in improving symptoms of depression driven by stress. Improved mood significantly Most Useful Review 4 people found this helpful These vitamins are excellent! I suggested them to my husband when he was feeling depressed and dissatisfied. After taking one capsule daily, his mood and energy improved noticeably within days! |
 Doctor's Best, Fully Active B Complex with Quatrefolic®, 30 Veggie Caps | | |
Vitamin B may alleviate depression symptoms[Effects of Vitamin B on Behaviors, Brain Monoamine Neurotransmitters, and Brain-Derived Neurotrophic Factor in Depressive Rats]. Our investigation looked into how Vitamin B affects behavior and neurotransmitter levels in rats undergoing stress-induced depression.
We set up three groups: a control group, a stressed group, and a stressed group receiving Vitamin B.
The results showed that Vitamin B improved neurotransmitter levels and reduced anxiety and depression-like behaviors in the rats. This suggests that Vitamin B could be beneficial in improving symptoms of depression driven by stress. Improved mood Most Useful Review 5 people found this helpful I looked up "AWESOME" in the dictionary and found this. It's essential for anyone suffering from lethargy, depression, or illness, particularly if they struggle to absorb B vitamins. |
 Solgar, B-Complex "50", 100 Vegetable Capsules | | |
Vitamin B may alleviate depression symptoms[Effects of Vitamin B on Behaviors, Brain Monoamine Neurotransmitters, and Brain-Derived Neurotrophic Factor in Depressive Rats]. Our investigation looked into how Vitamin B affects behavior and neurotransmitter levels in rats undergoing stress-induced depression.
We set up three groups: a control group, a stressed group, and a stressed group receiving Vitamin B.
The results showed that Vitamin B improved neurotransmitter levels and reduced anxiety and depression-like behaviors in the rats. This suggests that Vitamin B could be beneficial in improving symptoms of depression driven by stress. Reduced insomnia Most Useful Review 31 people found this helpful This is the best B vitamin complex. It saved me from insomnia and mild depression, providing energy, focus, and improved mood. The can is large enough for two courses, making it economical. However, it's unfortunate that they are no longer available for order to Russia. |
 Garden of Life, Vitamin Code, RAW B-Complex, 120 Vegan Capsules | | |
Vitamin B may alleviate depression symptoms[Effects of Vitamin B on Behaviors, Brain Monoamine Neurotransmitters, and Brain-Derived Neurotrophic Factor in Depressive Rats]. Our investigation looked into how Vitamin B affects behavior and neurotransmitter levels in rats undergoing stress-induced depression.
We set up three groups: a control group, a stressed group, and a stressed group receiving Vitamin B.
The results showed that Vitamin B improved neurotransmitter levels and reduced anxiety and depression-like behaviors in the rats. This suggests that Vitamin B could be beneficial in improving symptoms of depression driven by stress. Increased vitality Most Useful Review 24 people found this helpful I've been taking this B vitamin complex for two months. Even with a prophylactic dose of one capsule, I've noticed an increase in vitality, endurance against stress, and improved mood. These vitamins are highly effective for me, and I will continue to purchase them. |
 Life Extension, BioActive Complete B-Complex, 60 Vegetarian Capsules | | |
Vitamin B may alleviate depression symptoms[Effects of Vitamin B on Behaviors, Brain Monoamine Neurotransmitters, and Brain-Derived Neurotrophic Factor in Depressive Rats]. Our investigation looked into how Vitamin B affects behavior and neurotransmitter levels in rats undergoing stress-induced depression.
We set up three groups: a control group, a stressed group, and a stressed group receiving Vitamin B.
The results showed that Vitamin B improved neurotransmitter levels and reduced anxiety and depression-like behaviors in the rats. This suggests that Vitamin B could be beneficial in improving symptoms of depression driven by stress. Significant health improvement Most Useful Review 90 people found this helpful After a month of using this vitamin, I noticed a considerable improvement in my overall health. It specifically aided me in overcoming depression, which I had struggled with for a long time. If you seek a supplement that benefits not just your physical health but your overall well-being, I highly recommend this one. |
 Jarrow Formulas, Vegan Methyl B-12 & Methyl Folate, Extra Strength, Lemon, 100 Chewable Tablets | | |
Vitamin B12 shows no benefit for depressionAssessment of Vitamin B12 Efficacy on Cognitive Memory Function and Depressive Symptoms: A Systematic Review and Meta-Analysis. We assessed the effect of vitamin B12 supplementation on depressive symptoms by reviewing several randomized controlled trials (RCTs). Our analysis focused on participants who may experience mild cognitive impairment, an area where low vitamin B12 levels could potentially raise the risk of depression.
After a thorough examination of studies, we found that the included trials did not support a significant benefit of vitamin B12 for alleviating depressive symptoms. In our evaluation of three studies focusing specifically on depression, the average difference in symptoms was negligible, indicating no real effect.
This outcome reflects that while vitamin B12 is essential for various bodily functions, its role in improving mood and reducing depression symptoms may not be as effective as some might hope. Further exploration is still warranted to better understand the contexts in which vitamin B12 could be beneficial. Cognitive function enhanced Most Useful Review 2 people found this helpful This product combines active forms of vitamins to support DNA synthesis, neurotransmitter function, and amino acid metabolism. It is beneficial for brain activity, red blood cell formation, and cognitive functions. Additionally, it helps to alleviate depression and normalise hormones. |
 Jarrow Formulas, Curcumin 95, Turmeric Extract, 500 mg, 120 Veggie Capsules | | |
Curcumin reduces depression severityCurcumin Reduces Depression in Obese Patients with Type 2 Diabetes: A Randomized Controlled Trial. We conducted a study to explore the effects of curcumin, a natural supplement found in turmeric, on depression among obese patients with type 2 diabetes. Using a randomized, double-blind, placebo-controlled approach, we engaged 227 participants to assess how curcumin might help alleviate symptoms of depression.
Over the course of 12 months, we monitored changes in depression severity using a standard questionnaire, the Patient Health Questionnaire-9. Additionally, we evaluated various biomarkers such as serotonin levels, inflammatory markers, and antioxidant activity to better understand curcumin's potential benefits.
Our findings were quite promising. By the end of the study, those taking curcumin reported significantly lower depression severity. We also observed that curcumin increased serotonin levels while reducing markers associated with inflammation. Improvements in antioxidant activity were noted in the curcumin group too.
Overall, these results suggest that curcumin could be a beneficial addition to the treatment plan for individuals dealing with depression, particularly for those who are also managing obesity and type 2 diabetes. This research not only highlights the antidepressant effects of curcumin but also emphasizes the importance of holistic approaches in healthcare. Fights depression effectively Most Useful Review Curcumin demonstrates powerful antioxidant properties that enhance heart health and may aid in preventing cancer. It also helps combat depression by blocking inflammatory signals. It has proven effective compared to some anti-inflammatory drugs in certain studies. |
 Nature's Way, Vitamin B-6, 50 mg, 100 Capsules | | |
Vitamin B6 effectively battles depressionVitamin B6 Antidepressant Effects Are Comparable to Common Antidepressant Drugs in Bacillus-Calmette-Guerin Induced Depression Model in Mice. We explored the potential of vitamin B6 in treating depression, particularly how it compares to commonly used antidepressants. In our experiment, male mice were given a single dose of Bacillus-Calmette-Guerin (BCG) to induce depressive-like behaviors. Following this, we administered vitamin B6 alongside popular antidepressants such as fluoxetine, imipramine, and venlafaxine, to see how effectively each treatment mitigated symptoms over 14 days.
Our findings highlighted that vitamin B6 was effective in alleviating depression in the mice, just like the other antidepressant medications. The animals displayed significant improvements in both despair and anhedonia—key indicators of depression. Specifically, we noticed a decrease in immobility time during a forced swim test, indicating reduced despair. Plus, the latency to feed and food consumption improved significantly, showing that vitamin B6 helped counteract the depressive behaviors caused by BCG.
Overall, our research suggests that vitamin B6 can be a powerful ally in preventing depression, similar in effectiveness to some existing antidepressant drugs. We believe this opens the door for further clinical research on vitamin B6 as a potential treatment, especially for those at high risk for depression. Effective for depression Most Useful Review 6 people found this helpful I started taking it due to low ASt and ALt levels, which indicate a lack of B6 and high homocysteine. It helps in improving glucose metabolism and lowers blood sugar levels. B6 acts as a diuretic, reducing fluid retention and blood pressure. It is effective for depression and anxiety, especially alongside magnesium. When taken with Q10, it also aids concentration, while B6 and its transdermal forms can help with acne and skin conditions. |
 NOW Foods, P-5-P, 50 mg, 90 Veg Capsules | | |
Vitamin B6 effectively battles depressionVitamin B6 Antidepressant Effects Are Comparable to Common Antidepressant Drugs in Bacillus-Calmette-Guerin Induced Depression Model in Mice. We explored the potential of vitamin B6 in treating depression, particularly how it compares to commonly used antidepressants. In our experiment, male mice were given a single dose of Bacillus-Calmette-Guerin (BCG) to induce depressive-like behaviors. Following this, we administered vitamin B6 alongside popular antidepressants such as fluoxetine, imipramine, and venlafaxine, to see how effectively each treatment mitigated symptoms over 14 days.
Our findings highlighted that vitamin B6 was effective in alleviating depression in the mice, just like the other antidepressant medications. The animals displayed significant improvements in both despair and anhedonia—key indicators of depression. Specifically, we noticed a decrease in immobility time during a forced swim test, indicating reduced despair. Plus, the latency to feed and food consumption improved significantly, showing that vitamin B6 helped counteract the depressive behaviors caused by BCG.
Overall, our research suggests that vitamin B6 can be a powerful ally in preventing depression, similar in effectiveness to some existing antidepressant drugs. We believe this opens the door for further clinical research on vitamin B6 as a potential treatment, especially for those at high risk for depression. Cognition and mood improvement Most Useful Review 1 people found this helpful This product comes in an active form, and I take it with methyl folate and methyl cobalamin to improve my cognitive function and alleviate symptoms of depression. The results have been exceptional. |
 Solgar, Vitamin B6, 25 mg, 100 Tablets | | |
Vitamin B6 effectively battles depressionVitamin B6 Antidepressant Effects Are Comparable to Common Antidepressant Drugs in Bacillus-Calmette-Guerin Induced Depression Model in Mice. We explored the potential of vitamin B6 in treating depression, particularly how it compares to commonly used antidepressants. In our experiment, male mice were given a single dose of Bacillus-Calmette-Guerin (BCG) to induce depressive-like behaviors. Following this, we administered vitamin B6 alongside popular antidepressants such as fluoxetine, imipramine, and venlafaxine, to see how effectively each treatment mitigated symptoms over 14 days.
Our findings highlighted that vitamin B6 was effective in alleviating depression in the mice, just like the other antidepressant medications. The animals displayed significant improvements in both despair and anhedonia—key indicators of depression. Specifically, we noticed a decrease in immobility time during a forced swim test, indicating reduced despair. Plus, the latency to feed and food consumption improved significantly, showing that vitamin B6 helped counteract the depressive behaviors caused by BCG.
Overall, our research suggests that vitamin B6 can be a powerful ally in preventing depression, similar in effectiveness to some existing antidepressant drugs. We believe this opens the door for further clinical research on vitamin B6 as a potential treatment, especially for those at high risk for depression. Less depression noted Most Useful Review 1 people found this helpful I heard that vitamin B6 is helpful for PMS, so I commenced taking it about a week to ten days before my period. I no longer experience headaches, and my depression has also decreased. I will continue this supplement from before my period until it ends. |
 Natrol, 5-HTP, Time Release, 100 mg, 45 Tablets | | |
5-HTP shows limited effectivenessEffects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis. We explored the impact of 5-hydroxytryptophan (5-HTP) as a treatment for depression through a systematic review and meta-analysis.
Our analysis included 13 studies, revealing a depression remission rate of 65%. While this sounds promising, the research shows considerable variability in factors like treatment duration and types of depression tackled.
Additionally, the overall quality of the studies was weak, with many lacking proper control groups. To truly understand 5-HTP's effectiveness, more rigorous, placebo-controlled trials are essential. Lifesaver for depression Most Useful Review 10 people found this helpful This product is the best thing I've done to fight my depression. One pill each morning works wonders all day long. After suffering for nearly fifteen years with depression, this affordable product has provided real results. |
 NOW Foods, 5-HTP, 100 mg, 120 Veg Capsules | | |
5-HTP shows limited effectivenessEffects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis. We explored the impact of 5-hydroxytryptophan (5-HTP) as a treatment for depression through a systematic review and meta-analysis.
Our analysis included 13 studies, revealing a depression remission rate of 65%. While this sounds promising, the research shows considerable variability in factors like treatment duration and types of depression tackled.
Additionally, the overall quality of the studies was weak, with many lacking proper control groups. To truly understand 5-HTP's effectiveness, more rigorous, placebo-controlled trials are essential. Seasonal blues alleviated Most Useful Review 197 people found this helpful It effectively helps combat the seasonal blues, relieves depression, and calms shattered nerves. |
 NOW Foods, Selenium, 100 mcg, 100 Tablets | | |
Selenium's potential in depression treatmentAntidepressant-Like Effect of a Selenoindolizine in Mice: In Vivo and In Silico Evidence for the Involvement of the Serotonergic 5-HT Receptors. This study explored how a selenium-containing compound, SeI, impacts depression-like behavior in mice. During behavioral tests, this compound reduced immobility, signaling an antidepressant-like effect without affecting movement.
Notably, blocking specific serotonin receptors changed the results, indicating the serotonergic system's involvement. With a low potential for side effects, SeI shows promise for developing new treatments for major depressive disorder (MDD).
However, it's important to note this research was conducted in mice, so effects in humans remain unconfirmed. Significant improvement Most Useful Review 96 people found this helpful This product has been a life changer for me. I felt a great deal of fatigue and depression. Now, I've never been in better shape in my life and have lost 14 pounds. I've been eating healthier and exercising more than ever before, and this vitamin has helped me return to my healthiest self without any supplements. |
 NOW Foods, Selenium, 200 mcg, 180 Veg Capsules | | |
Selenium's potential in depression treatmentAntidepressant-Like Effect of a Selenoindolizine in Mice: In Vivo and In Silico Evidence for the Involvement of the Serotonergic 5-HT Receptors. This study explored how a selenium-containing compound, SeI, impacts depression-like behavior in mice. During behavioral tests, this compound reduced immobility, signaling an antidepressant-like effect without affecting movement.
Notably, blocking specific serotonin receptors changed the results, indicating the serotonergic system's involvement. With a low potential for side effects, SeI shows promise for developing new treatments for major depressive disorder (MDD).
However, it's important to note this research was conducted in mice, so effects in humans remain unconfirmed. Depression alleviated Most Useful Review 6 people found this helpful This selenium from IHerb is remarkable. As someone with a goitre, I take it alongside iodine. Since I started, my depression has vanished, and I feel fantastic. It assists with iodine absorption, and I've noticed fewer colds. I take 200 mcg daily for myself and 100 mcg for my daughter each morning with breakfast. Overall, I feel a boost in my health. |
 Life Extension, Super Selenium Complex & Vitamin E, 200 mcg, 100 Vegetarian Capsules | | |
Selenium's potential in depression treatmentAntidepressant-Like Effect of a Selenoindolizine in Mice: In Vivo and In Silico Evidence for the Involvement of the Serotonergic 5-HT Receptors. This study explored how a selenium-containing compound, SeI, impacts depression-like behavior in mice. During behavioral tests, this compound reduced immobility, signaling an antidepressant-like effect without affecting movement.
Notably, blocking specific serotonin receptors changed the results, indicating the serotonergic system's involvement. With a low potential for side effects, SeI shows promise for developing new treatments for major depressive disorder (MDD).
However, it's important to note this research was conducted in mice, so effects in humans remain unconfirmed. Reduced anxiety Most Useful Review After a month of taking selenium, I’ve found that my anxiety, depression, and insomnia have subsided. I feel much lighter and more at ease. |
 NOW Foods, Milk Thistle Extract, Double Strength, 300 mg, 200 Veg Capsules | | |
Silibinin reduces depression in miceSilibinin ameliorates depression/anxiety-like behaviors of Parkinson's disease mouse model and is associated with attenuated STING-IRF3-IFN-β pathway activation and neuroinflammation. We investigated the impact of silibinin, a natural compound from Silybum marianum, on depression and anxiety in mice with Parkinson's disease. Through various behavioral tests, we found that silibinin significantly reduced depressive and anxious behaviors caused by MPTP, a chemical used to induce these symptoms.
Additionally, silibinin helped repair neuronal damage in the hippocampus and restored levels of important mood-regulating neurotransmitters. It also reduced markers of neuroinflammation linked to depression, suggesting silibinin may hold promise as a treatment for these conditions in Parkinson's. Improved well-being Most Useful Review 1 people found this helpful I really like this company, as the quality is good. My liver feels better with this product after a month. However, if I stop using it, I experience issues again. Milk Thistle has effects beyond liver health; it aids in tissue repair and even depression. I will continue taking this supplement. |
 NOW Foods, L-Theanine, 100 mg, 90 Veg Capsules | | |
L-theanine shows potential antidepressant effectsL-theanine ameliorate depressive-like behavior in a chronic unpredictable mild stress rat model via modulating the monoamine levels in limbic-cortical-striatal-pallidal-thalamic-circuit related brain regions. We examined how L-theanine, a compound found in green tea, influences depressive behaviors in a rat model. Using specific behavioral tests, such as the open-field and forced swim tests, we observed that L-theanine improved depressive-like behaviors.
Our findings indicated that it boosted levels of key neurotransmitters—serotonin, norepinephrine, and dopamine—in certain brain regions. This suggests that L-theanine could have potential antidepressant effects, possibly by interacting with these neurotransmitters in brain areas associated with mood regulation. Gentle stabilisation Most Useful Review 2 people found this helpful L-Theanine has significantly helped my nervous system without dulling my senses like other stress medications. It gently restores balance, improving sleep, work performance, and helping me overcome depression—all without dependency issues. I wholeheartedly recommend it. |
 Doctor's Best, L-Theanine, 150 mg, 90 Veggie Caps | | |
L-theanine shows potential antidepressant effectsL-theanine ameliorate depressive-like behavior in a chronic unpredictable mild stress rat model via modulating the monoamine levels in limbic-cortical-striatal-pallidal-thalamic-circuit related brain regions. We examined how L-theanine, a compound found in green tea, influences depressive behaviors in a rat model. Using specific behavioral tests, such as the open-field and forced swim tests, we observed that L-theanine improved depressive-like behaviors.
Our findings indicated that it boosted levels of key neurotransmitters—serotonin, norepinephrine, and dopamine—in certain brain regions. This suggests that L-theanine could have potential antidepressant effects, possibly by interacting with these neurotransmitters in brain areas associated with mood regulation. Stress reduced Most Useful Review 11 people found this helpful Simply having this in my bag makes me feel better. I find it brings a sense of peace without the chemical dullness typical of other stress or depression medications. The 150mg dosage per capsule seems just right—providing a subtle calming effect and alleviating feelings of paranoia. |
 NOW Foods, Double Strength L-Theanine, 200 mg, 120 Veg Capsules | | |
L-theanine shows potential antidepressant effectsL-theanine ameliorate depressive-like behavior in a chronic unpredictable mild stress rat model via modulating the monoamine levels in limbic-cortical-striatal-pallidal-thalamic-circuit related brain regions. We examined how L-theanine, a compound found in green tea, influences depressive behaviors in a rat model. Using specific behavioral tests, such as the open-field and forced swim tests, we observed that L-theanine improved depressive-like behaviors.
Our findings indicated that it boosted levels of key neurotransmitters—serotonin, norepinephrine, and dopamine—in certain brain regions. This suggests that L-theanine could have potential antidepressant effects, possibly by interacting with these neurotransmitters in brain areas associated with mood regulation. Alleviated anxiety Most Useful Review 57 people found this helpful I developed anxiety and depression, leading to unclear thoughts and emotional eating. This supplement transformed my well-being. I now feel like my old self, with reduced anxiety and improved focus, enabling me to manage stress calmly. It has significantly improved my sleep and overall mood. |
 NOW Foods, Iron, 18 mg, 120 Veg Capsules | | |
Nrf2's role in iron and depressionNrf2 regulates iron-dependent hippocampal synapses and functional connectivity damage in depression. We explored how iron levels impact depression and hippocampal health. By studying mice under chronic mild stress and using an iron chelator, we observed that excessive iron leads to synaptic damage in the brain. This harmful effect was linked to the downregulation of crucial proteins involved in brain health.
Interestingly, when we activated a protein called Nrf2, we saw improvements in iron balance and a reduction in depression symptoms. Our findings suggest that focusing on Nrf2 and managing iron levels could be key in developing better treatments for depression. Depression relief Most Useful Review 1 people found this helpful This product helped with my evening depression. I often felt unwell in the evenings, potentially due to iron deficiency, which led me to purchase it. After starting, my evening depression subsided and I began waking up feeling better. Now I can move through the day without fluctuations. I’d like to increase the dosage gradually, possibly trying 36mg in the future. |
 Solgar, Gentle Iron®, 25 mg, 90 Vegetable Capsules | | |
Nrf2's role in iron and depressionNrf2 regulates iron-dependent hippocampal synapses and functional connectivity damage in depression. We explored how iron levels impact depression and hippocampal health. By studying mice under chronic mild stress and using an iron chelator, we observed that excessive iron leads to synaptic damage in the brain. This harmful effect was linked to the downregulation of crucial proteins involved in brain health.
Interestingly, when we activated a protein called Nrf2, we saw improvements in iron balance and a reduction in depression symptoms. Our findings suggest that focusing on Nrf2 and managing iron levels could be key in developing better treatments for depression. Improved mood Most Useful Review 27 people found this helpful Iron bisglycinate is the best form for absorption. After months of use due to low ferritin levels, I haven't yet retested my blood but did notice an initial excitement followed by stability in mood. My menstrual blood loss has decreased. A reasonable psychiatrist will check ferritin levels in those with depression, as low ferritin can be a contributing factor. |
 Doctor's Best, NAC Detox Regulators with Seleno Excell®, 60 Veggie Caps | | |
Selenium's potential in depression treatmentAntidepressant-Like Effect of a Selenoindolizine in Mice: In Vivo and In Silico Evidence for the Involvement of the Serotonergic 5-HT Receptors. This study explored how a selenium-containing compound, SeI, impacts depression-like behavior in mice. During behavioral tests, this compound reduced immobility, signaling an antidepressant-like effect without affecting movement.
Notably, blocking specific serotonin receptors changed the results, indicating the serotonergic system's involvement. With a low potential for side effects, SeI shows promise for developing new treatments for major depressive disorder (MDD).
However, it's important to note this research was conducted in mice, so effects in humans remain unconfirmed. Super remedy confirmed Most Useful Review NAC is a super remedy for depression! |
 Life Extension, N-Acetyl-L-Cysteine, 600 mg, 60 Capsules | | |
Life-changing experience Most Useful Review For me, NAC has been life-changing! It effectively alleviates ruminations that lead to depression and OCD. A low dose of 600 mg each morning works wonders. Essential supplement Most Useful Review NAC is a supplement everyone should consider; it works as an antioxidant and effectively addresses depression. |
 Life Extension, Magnesium Caps, 500 mg, 100 Vegetarian Capsules | | |
Magnesium intake reduces depression riskDietary Magnesium Intake in Relation to Depression in Adults: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis of Epidemiologic Studies. We conducted a systematic review and meta-analysis exploring how dietary magnesium (Mg) intake connects with depression among adults. By reviewing data from over 63,000 individuals, we found that those with the highest magnesium intake had a 34% lower chance of experiencing depression compared to those with the lowest intake.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk. Improved well-being Most Useful Review 312 people found this helpful I had been experiencing constant sleepiness, headaches, irritability, and depression before starting magnesium. Using Magnesium Caps has helped me assimilate essential vitamins and minerals, thin my blood, and synthesise the hormone of joy. It effectively alleviated insomnia and my migraines, apathy and depression have vanished. I now feel refreshed after six hours of sleep and my mental clarity has improved significantly. I highly recommend it, especially when taken before bedtime! |
 Solgar, Magnesium with Vitamin B6, 250 Tablets | | |
Magnesium intake reduces depression riskDietary Magnesium Intake in Relation to Depression in Adults: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis of Epidemiologic Studies. We conducted a systematic review and meta-analysis exploring how dietary magnesium (Mg) intake connects with depression among adults. By reviewing data from over 63,000 individuals, we found that those with the highest magnesium intake had a 34% lower chance of experiencing depression compared to those with the lowest intake.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk. Support for well-being Most Useful Review 1 people found this helpful After taking magnesium B6 for two months as my doctor prescribed, I decided to leave a review. This product is a solid alternative to pharmacy magnesium B6—better in terms of price and quantity. Magnesium is vital for the body's proper functioning, aiding blood vessel strength, normalising blood pressure, and improving muscle relaxation, which helped me overcome depression. |
 Nature Made, Magnesium, 250 mg, 100 Tablets | | |
Magnesium intake reduces depression riskDietary Magnesium Intake in Relation to Depression in Adults: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis of Epidemiologic Studies. We conducted a systematic review and meta-analysis exploring how dietary magnesium (Mg) intake connects with depression among adults. By reviewing data from over 63,000 individuals, we found that those with the highest magnesium intake had a 34% lower chance of experiencing depression compared to those with the lowest intake.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk. Calms teenage depression Most Useful Review 1 people found this helpful We take magnesium as a family to combat aggression and depression. My eldest son, who is under stress at work, has become calmer. My 14-year-old daughter overcame adolescent depression with it, and my youngest, diagnosed with ADHD, shows reduced aggression. I'm very pleased with the results. |
 Doctor's Best, High Absorption Magnesium Powder, 7.1 oz (200 g) | | |
Magnesium intake reduces depression riskDietary Magnesium Intake in Relation to Depression in Adults: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis of Epidemiologic Studies. We conducted a systematic review and meta-analysis exploring how dietary magnesium (Mg) intake connects with depression among adults. By reviewing data from over 63,000 individuals, we found that those with the highest magnesium intake had a 34% lower chance of experiencing depression compared to those with the lowest intake.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk. Daily recommendation Most Useful Review 1 people found this helpful This magnesium type is excellent as it doesn't upset my stomach. I take two capsules at night and enjoy peaceful sleep, alongside relief from cramps. If you're dealing with depression and sadness, this product truly helps and should be part of your daily routine. Magnesium deficiency can have grave consequences, so I advocate for its use. |
 NATURELO, Magnesium Glycinate Chelate Complex, 120 Vegetarian Capsules | | |
Magnesium intake reduces depression riskDietary Magnesium Intake in Relation to Depression in Adults: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis of Epidemiologic Studies. We conducted a systematic review and meta-analysis exploring how dietary magnesium (Mg) intake connects with depression among adults. By reviewing data from over 63,000 individuals, we found that those with the highest magnesium intake had a 34% lower chance of experiencing depression compared to those with the lowest intake.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk. Essential for well-being Most Useful Review 3 people found this helpful Magnesium is vital for human health, with 60% found in bones. Chelated forms, such as Magnesium Glycinate, are absorbed faster and are gentle on digestion. It is prescribed for headaches, seizures, anxiety, and depression. I take 2 capsules at night and recommend this quality product. |
 Source Naturals, Magnesium Malate, 3,750 mg, 360 Tablets (1,250 mg per Tablet) | | |
Magnesium intake reduces depression riskDietary Magnesium Intake in Relation to Depression in Adults: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis of Epidemiologic Studies. We conducted a systematic review and meta-analysis exploring how dietary magnesium (Mg) intake connects with depression among adults. By reviewing data from over 63,000 individuals, we found that those with the highest magnesium intake had a 34% lower chance of experiencing depression compared to those with the lowest intake.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk. Helps with depression Most Useful Review 1 people found this helpful Great for depression. It truly assists with my depression. I'm utterly in love with its excellent qualities. |
 NOW Foods, Magnesium Malate, 1,000 mg, 180 Tablets | | |
Magnesium intake reduces depression riskDietary Magnesium Intake in Relation to Depression in Adults: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis of Epidemiologic Studies. We conducted a systematic review and meta-analysis exploring how dietary magnesium (Mg) intake connects with depression among adults. By reviewing data from over 63,000 individuals, we found that those with the highest magnesium intake had a 34% lower chance of experiencing depression compared to those with the lowest intake.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk. Helps depression Most Useful Review 1 people found this helpful I really like this product. It helps my depression, provides energy, and supports my muscles during training. |
 NOW Foods, Magnesium Citrate, 400 mg, 120 Veg Capsules (133 mg per Capsule) | | |
Magnesium intake reduces depression riskDietary Magnesium Intake in Relation to Depression in Adults: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis of Epidemiologic Studies. We conducted a systematic review and meta-analysis exploring how dietary magnesium (Mg) intake connects with depression among adults. By reviewing data from over 63,000 individuals, we found that those with the highest magnesium intake had a 34% lower chance of experiencing depression compared to those with the lowest intake.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk. Anger relief Most Useful Review Since starting magnesium citrate, my anger and depression have diminished, and my sleep has returned to normal. I've experienced no side effects after three months of use. |
 Life Extension, Neuro-Mag, Magnesium L-Threonate, 144 mg, 90 Vegetarian Capsules (48 mg per Capsule) | | |
Magnesium intake reduces depression riskDietary Magnesium Intake in Relation to Depression in Adults: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis of Epidemiologic Studies. We conducted a systematic review and meta-analysis exploring how dietary magnesium (Mg) intake connects with depression among adults. By reviewing data from over 63,000 individuals, we found that those with the highest magnesium intake had a 34% lower chance of experiencing depression compared to those with the lowest intake.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk. Calming effect Most Useful Review 7 people found this helpful Excellent magnesium! I fell asleep peacefully on the first day. As a disabled person recovering from a serious craniocerebral injury, I faced stress, depression, and insomnia. Now, I feel calm and content; my sleep has improved, and my mood has returned. I'm grateful for this product! |
 NOW Foods, Magnesium Caps, 400 mg, 180 Veg Capsules | | |
Magnesium intake reduces depression riskDietary Magnesium Intake in Relation to Depression in Adults: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis of Epidemiologic Studies. We conducted a systematic review and meta-analysis exploring how dietary magnesium (Mg) intake connects with depression among adults. By reviewing data from over 63,000 individuals, we found that those with the highest magnesium intake had a 34% lower chance of experiencing depression compared to those with the lowest intake.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk. Reduced anxiety Most Useful Review 16 people found this helpful Every woman should consider magnesium, as deficiency can lead to heart issues and affect mental health, causing anxiety and depression. After taking one capsule daily, my leg cramps vanished, I became calmer, and my insomnia improved significantly. I find it a bargain for six months' supply. |
 Doctor's Best, High Absorption Magnesium, 200 mg, 120 Tablets, (100 mg per Tablet) | | |
Magnesium intake reduces depression riskDietary Magnesium Intake in Relation to Depression in Adults: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis of Epidemiologic Studies. We conducted a systematic review and meta-analysis exploring how dietary magnesium (Mg) intake connects with depression among adults. By reviewing data from over 63,000 individuals, we found that those with the highest magnesium intake had a 34% lower chance of experiencing depression compared to those with the lowest intake.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk. Effective depression relief Most Useful Review 69 people found this helpful I take it to relieve symptoms of depression. I'm surprised by the clear effects; I had a terrible experience in psychiatry and prefer controlling my mental state with magnesium now. It’s critical not to exceed 300mg daily since I’ve read that long-term use of ineffective psychotropic medications can shorten life expectancy. I feel empowered with magnesium and find it more effective than psychosomatic treatments. |
 Jarrow Formulas, Vegan MagMind, Brain Health, 144 mg, 90 Veggie Capsules (48 mg per Capsule) | | |
Magnesium intake reduces depression riskDietary Magnesium Intake in Relation to Depression in Adults: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis of Epidemiologic Studies. We conducted a systematic review and meta-analysis exploring how dietary magnesium (Mg) intake connects with depression among adults. By reviewing data from over 63,000 individuals, we found that those with the highest magnesium intake had a 34% lower chance of experiencing depression compared to those with the lowest intake.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk. Miracle solution Most Useful Review 5 people found this helpful As a mother of three, I pushed myself to the brink of depression. Looking for a solution, I opted for this product based on positive reviews. After just two weeks, I felt revitalised. I can now manage my emotions better and have newfound energy, making it worthwhile despite the cost. I highly recommend it! |
 Carlson, Wild Norwegian, Elite Omega-3 Gems®, Natural Lemon, 120 Soft Gels | | |
Omega-3 fatty acids show promiseThe Efficacy of Omega-3 Fatty Acids as the Monotherapy for Depression: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. We conducted a study to see if omega-3 fatty acids could help people with major depressive disorder as a standalone treatment. Over 12 weeks, 60 participants took either omega-3 supplements or a placebo.
Results showed that those taking omega-3 had lower depression scores at various points throughout the study. While there were hints of improved outcomes in terms of remission and response rates, these weren't statistically significant.
Overall, omega-3 fatty acids could be a promising alternative, but further research is necessary to confirm their effectiveness. Mood improvement Most Useful Review 211 people found this helpful I have tried numerous omega brands and this one is by far my favourite. If you take 2 capsules daily, it lasts two months, which is quite economical. I experience a light citrus burp instead of fishy, which is a plus. It has improved my hair and nails and helped my post-Covid depression significantly. The packaging is excellent and the capsules, though large and straw-yellow, are easy to swallow. Drinking omega is advisable for everyone, as it truly enhances health and mood. |
 Nordic Naturals, Omega-3, Great Lemon, 690 mg, 120 Soft Gels (345 mg per Soft Gel) | | |
Omega-3 fatty acids show promiseThe Efficacy of Omega-3 Fatty Acids as the Monotherapy for Depression: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. We conducted a study to see if omega-3 fatty acids could help people with major depressive disorder as a standalone treatment. Over 12 weeks, 60 participants took either omega-3 supplements or a placebo.
Results showed that those taking omega-3 had lower depression scores at various points throughout the study. While there were hints of improved outcomes in terms of remission and response rates, these weren't statistically significant.
Overall, omega-3 fatty acids could be a promising alternative, but further research is necessary to confirm their effectiveness. Improved mood Most Useful Review 96 people found this helpful This product is my favourite so far. With two cans and following the instructions to take 2 capsules daily, it lasts for exactly two months, making it quite affordable. I experienced a slight burp, but it was citrus rather than the fishy taste common with many others, which is definitely a plus. After taking it, I noticed that my quality of life improved, with my hair and nails getting better. Following covid, I had a slight depression and a depressed state, but this omega resolved those issues effectively. The capsules are large, straw-yellow, and easy to swallow. |
 Jarrow Formulas, Fish Oil, EPA-DHA Balance®, 120 Softgels | | |
Omega-3 fatty acids show promiseThe Efficacy of Omega-3 Fatty Acids as the Monotherapy for Depression: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. We conducted a study to see if omega-3 fatty acids could help people with major depressive disorder as a standalone treatment. Over 12 weeks, 60 participants took either omega-3 supplements or a placebo.
Results showed that those taking omega-3 had lower depression scores at various points throughout the study. While there were hints of improved outcomes in terms of remission and response rates, these weren't statistically significant.
Overall, omega-3 fatty acids could be a promising alternative, but further research is necessary to confirm their effectiveness. Antidepressant effect Most Useful Review 8 people found this helpful This product is fantastic for trying Omega-3 without taking multiple capsules. I've noticed a significant antidepressant effect, particularly in boosted dopamine levels, leading to reduced mental and physical fatigue. After just 5 capsules, I've cut back on other supplements for depression. I believe I had a long-standing Omega-3 deficiency. |
 Deva, Vegan Omega-3 DHA, 200 mg, 90 Softgels | | |
Omega-3 fatty acids show promiseThe Efficacy of Omega-3 Fatty Acids as the Monotherapy for Depression: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. We conducted a study to see if omega-3 fatty acids could help people with major depressive disorder as a standalone treatment. Over 12 weeks, 60 participants took either omega-3 supplements or a placebo.
Results showed that those taking omega-3 had lower depression scores at various points throughout the study. While there were hints of improved outcomes in terms of remission and response rates, these weren't statistically significant.
Overall, omega-3 fatty acids could be a promising alternative, but further research is necessary to confirm their effectiveness. Alleviates depression Most Useful Review 2 people found this helpful I began taking this vegan DHA during my pregnancy, and I’ve continued as it significantly alleviates my depression. I've tried other brands, but none have worked as effectively as Deva. |
 Natrol, Omega-3 Fish Oil, Lemon, 1,000 mg, 150 Softgels | | |
Omega-3 fatty acids show promiseThe Efficacy of Omega-3 Fatty Acids as the Monotherapy for Depression: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. We conducted a study to see if omega-3 fatty acids could help people with major depressive disorder as a standalone treatment. Over 12 weeks, 60 participants took either omega-3 supplements or a placebo.
Results showed that those taking omega-3 had lower depression scores at various points throughout the study. While there were hints of improved outcomes in terms of remission and response rates, these weren't statistically significant.
Overall, omega-3 fatty acids could be a promising alternative, but further research is necessary to confirm their effectiveness. Depression relief Most Useful Review 9 people found this helpful This brand of fish oil has helped lift my permanent depression. There's no unpleasant fish taste or odour, and it works well compared to other Omega-3 brands I've tried. |
 Doctor's Best, Purified & Clear Omega 3 Fish Oil, 2,000 mg, 120 Marine Softgels (1,000 mg per Softgel) | | |
Omega-3 fatty acids show promiseThe Efficacy of Omega-3 Fatty Acids as the Monotherapy for Depression: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. We conducted a study to see if omega-3 fatty acids could help people with major depressive disorder as a standalone treatment. Over 12 weeks, 60 participants took either omega-3 supplements or a placebo.
Results showed that those taking omega-3 had lower depression scores at various points throughout the study. While there were hints of improved outcomes in terms of remission and response rates, these weren't statistically significant.
Overall, omega-3 fatty acids could be a promising alternative, but further research is necessary to confirm their effectiveness. Combats anxiety Most Useful Review Omega-3 fatty acids play a crucial role in cardiovascular health by lowering cholesterol and preventing inflammation. They enhance brain function by improving memory and concentration while combating depression and anxiety. Additionally, Omega-3s contribute to healthy skin by moisturising and reducing inflammation, such as acne and eczema. Regular consumption also helps strengthen joints, minimising pain from inflammation. |
 NOW Foods, Ultra Omega 3-D, 600 EPA / 300 DHA, 90 Fish Softgels | | |
Omega-3 fatty acids show promiseThe Efficacy of Omega-3 Fatty Acids as the Monotherapy for Depression: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. We conducted a study to see if omega-3 fatty acids could help people with major depressive disorder as a standalone treatment. Over 12 weeks, 60 participants took either omega-3 supplements or a placebo.
Results showed that those taking omega-3 had lower depression scores at various points throughout the study. While there were hints of improved outcomes in terms of remission and response rates, these weren't statistically significant.
Overall, omega-3 fatty acids could be a promising alternative, but further research is necessary to confirm their effectiveness. Relief from symptoms Most Useful Review Following my doctor's advice, I used ultra Omega, which yielded excellent results. My son suffers from depression, and this product has significantly alleviated his symptoms. I appreciate the manufacturer's efforts. |
 NOW Foods, Omega-3 Fish Oil, 1,000 mg, 180 EPA - 120 DHA, 100 Softgels | | |
Omega-3 fatty acids show promiseThe Efficacy of Omega-3 Fatty Acids as the Monotherapy for Depression: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. We conducted a study to see if omega-3 fatty acids could help people with major depressive disorder as a standalone treatment. Over 12 weeks, 60 participants took either omega-3 supplements or a placebo.
Results showed that those taking omega-3 had lower depression scores at various points throughout the study. While there were hints of improved outcomes in terms of remission and response rates, these weren't statistically significant.
Overall, omega-3 fatty acids could be a promising alternative, but further research is necessary to confirm their effectiveness. Improved skin condition Most Useful Review 7 people found this helpful Omega-3 fatty acids are essential and must be obtained from food or supplements, as the body cannot produce them. They help manage depression and improve skin health. Many individuals with conditions like eczema find their skin improves with Omega-3 intake. I noticed better sleep and increased energy levels after taking Omega from NOW FOODS. It offers a great price-to-quality ratio with 200 capsules lasting for three months. |
 Solgar, Omega 3, EPA & DHA, Triple Strength, 950 mg, 100 Softgels | | |
Omega-3 fatty acids show promiseThe Efficacy of Omega-3 Fatty Acids as the Monotherapy for Depression: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. We conducted a study to see if omega-3 fatty acids could help people with major depressive disorder as a standalone treatment. Over 12 weeks, 60 participants took either omega-3 supplements or a placebo.
Results showed that those taking omega-3 had lower depression scores at various points throughout the study. While there were hints of improved outcomes in terms of remission and response rates, these weren't statistically significant.
Overall, omega-3 fatty acids could be a promising alternative, but further research is necessary to confirm their effectiveness. Effective mood regulation Most Useful Review 12 people found this helpful The supplement has genuinely helped with my mood swings and depression. Taking two softgels daily works wonders, but when I stop, the mood fluctuations return. |
 Jarrow Formulas, PS100, Phosphatidylserine, 100 mg, 120 Softgels | | |
Antidepressive effects observed in studyPhosphatidylserine: an antidepressive or a cognitive enhancer? We investigated whether phosphatidylserine (BC-PS) could effectively treat depression and enhance cognitive function. In our study, rats took BC-PS in various doses and were compared to a control group. We observed that BC-PS significantly reduced how long the rats remained immobile in a stress test, suggesting an antidepressive effect.
However, when it came to improving memory in different maze tasks, BC-PS showed no significant benefits compared to the control group. This indicates that while BC-PS may help with depression, it doesn't appear to boost cognitive abilities. Alleviates seasonal depression Most Useful Review 61 people found this helpful No soy from Jerow! The phosphatidylserine is sourced from sunflower, which is a significant advantage. It's beneficial for the nervous system, aids in seasonal depression, lowers cortisol levels and enhances cognitive functions like thinking and memory. Overall, all the supplements from Jerow that I ordered here are effective! |
 21st Century, Acidophilus Probiotic Blend, 150 Capsules | | |
Probiotics reduce anxiety in rats[Antioxidant and anxiolytic effect of and under conditions of normobaric hypoxia with hypercapnia]. We investigated whether administering Lactobacillus acidophilus could alleviate anxiety and oxidative stress in rats, particularly during challenging conditions like hypoxia.
In our study, rats were divided into groups and given probiotics over 30 days. Those treated with Lactobacillus showed less oxidative damage and anxiety than the untreated hypoxia group.
Overall, we found that Lactobacillus acidophilus contributes to reducing anxiety levels, potentially offering an interesting avenue for mental health treatment. Overall health benefits Most Useful Review 7 people found this helpful Truly incredible! A beautiful probiotic product with high quality and useful ingredients. The 150-capsule package is perfect. It offers numerous advantages for overall health, containing beneficial bacteria to protect the digestive system. It supports digestion and is effective for constipation and diarrhoea. Additionally, it promotes heart health by lowering blood pressure and reducing harmful cholesterol. It's particularly beneficial for those taking medication, relieving anxiety and depression, while also enhancing skin health and aiding in weight loss. Taken once daily on an empty stomach in the morning—thank you! |
 Garden of Life, Dr. Formulated Probiotics, Mood+, 60 Vegetarian Capsules | | |
DHA shows potential for depressionThe Efficacy of Omega-3 Fatty Acids as the Monotherapy for Depression: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. We conducted a study to find out whether docosahexaenoic acid (DHA), a type of omega-3 fatty acid, could effectively help those dealing with major depressive disorder (MDD). Over the course of 12 weeks, 60 participants were involved in a double-blind, placebo-controlled trial. They were divided into two groups: one received 3.2 grams of DHA daily, while the other group was given an equivalent amount of soybean oil as a placebo.
Throughout the study, we measured depression levels using the Hamilton Rating Scale for Depression (HRSD). Our results were intriguing—those taking the DHA showed significant improvements in their depression scores compared to the placebo group by weeks 4, 6, 8, and 12. While we noted that 26.7% of participants receiving DHA achieved remission by week 12, this was not statistically significant in comparison to the placebo group.
Overall, our findings support the idea that DHA may serve as a promising alternative treatment for individuals suffering from MDD. Although the results are encouraging, we recognize the need for further research to confirm these benefits conclusively. Effective for depression Most Useful Review 23 people found this helpful I am satisfied with these probiotics, which support emotional well-being. They contain strains that help calm feelings, relieve stress, and promote relaxation. I previously took a different brand last winter but found similar strains. This product particularly enhanced my mood, which was crucial given my seasonal depression. I noticed substantial improvement in my feelings, likely due to the probiotic strains used, rather than just an ingredient like Ash, which I consumed separately. Unlike my previous product, this one doesn't compromise mood support. It even contains acacia fibre, beneficial for gut health, and I plan to repurchase. |
 Rainbow Light, Prenatal One™ Daily Multivitamin, High Potency, 150 Vegan Tablets | | |
No depression Most Useful Review These are my favourite vitamins! I began taking them while planning for pregnancy and continued to do so. My child is now 1.8 years old. They didn’t entirely prevent me from experiencing toxicosis, but I felt more energetic overall. After my cesarean, I recovered quickly without suffering from depression. No depression Most Useful Review After giving birth, I started taking these vitamins and felt fantastic. My skin is clear, my hair is thick, and I’m in a great mood. I didn’t experience any postpartum depression or fatigue, showing a marked improvement in my wellbeing. |
 Garden of Life, Vitamin Code, RAW Prenatal, 90 Vegetarian Capsules | | |
Depression treatment success Most Useful Review 6 people found this helpful I was overwhelmed by severe postpartum depression that persisted for months. Despite my therapist's efforts, my situation remained dire until I tried these vitamins. After just three days of taking them, my mental state dramatically improved. The vitamins seemed to provide me with the sustenance I desperately needed during this busy period of breastfeeding. I highly recommend these vitamins, especially for nursing mothers experiencing similar struggles. Managed depression effectively Most Useful Review I searched for vitamins suitable for me during my pregnancy, concerned about their composition. I found these non-synthetic vitamins free from harmful additives. The results were remarkable; I felt energetic, cheerful with no mood swings or depression throughout my pregnancy. All my blood tests were excellent, and I maintained both my physical health and the child's wellbeing. I highly recommend these vitamins! |
 Garden of Life, Organics, Ashwagandha, 60 Vegan Tablets | | |
Enhances mental health Most Useful Review Quality is good for treating depression and balancing cortisone levels. The ingredients positively impact mental health, though somewhat expensive. The fragrance is delightful. Better sleep Most Useful Review It helps with depression and stress. After eating, I can sleep better and feel calmer. |
 Nordic Naturals, Prenatal DHA, 90 Soft Gels | | |
Vitamin D3 improves depressive symptomsEffects of vitamin D supplementation on depression and some selected pro-inflammatory biomarkers: a double-blind randomized clinical trial. We conducted a double-blind randomized clinical trial to explore the effects of vitamin D3 supplementation on depression. Our study involved 56 adults with mild to moderate depression, who were assigned to either a vitamin D group or a placebo group. Over the course of eight weeks, the vitamin D group received a high dose of 50,000 IU cholecalciferol every two weeks, while the control group received a placebo.
After the treatment period, we observed that the participants who received the vitamin D3 experienced a significant reduction in depression severity, as measured by the Beck Depression Inventory-II. Interestingly, this improvement in mood occurred independently of any changes in inflammatory biomarkers like IL-1β, IL-6, and hs-CRP, which we also assessed during the study.
This indicates that while vitamin D supplementation may positively impact depressive symptoms, its effects are not directly linked to the inflammatory markers we evaluated. Our findings suggest that vitamin D3 could be a helpful addition to depression treatment strategies, particularly in individuals with low vitamin D levels. Depression prevention Most Useful Review 46 people found this helpful Excellent prenatal vitamins! Omega-3 plays a crucial role in pregnancy, helping to reduce the risk of late toxicity and depression. Nordic Naturals is entirely safe, with independent testing confirming high safety standards. Their production process eliminates heavy metals and dioxins, ensuring quality. The capsules have a pleasant taste and don't cause belching, which is common with many fish oils. |
 Minami Nutrition, Supercritical Prenatal, Omega-3 Fish Oil, Lemon, 60 Softgels | | |
DHA shows potential for depressionThe Efficacy of Omega-3 Fatty Acids as the Monotherapy for Depression: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. We conducted a study to find out whether docosahexaenoic acid (DHA), a type of omega-3 fatty acid, could effectively help those dealing with major depressive disorder (MDD). Over the course of 12 weeks, 60 participants were involved in a double-blind, placebo-controlled trial. They were divided into two groups: one received 3.2 grams of DHA daily, while the other group was given an equivalent amount of soybean oil as a placebo.
Throughout the study, we measured depression levels using the Hamilton Rating Scale for Depression (HRSD). Our results were intriguing—those taking the DHA showed significant improvements in their depression scores compared to the placebo group by weeks 4, 6, 8, and 12. While we noted that 26.7% of participants receiving DHA achieved remission by week 12, this was not statistically significant in comparison to the placebo group.
Overall, our findings support the idea that DHA may serve as a promising alternative treatment for individuals suffering from MDD. Although the results are encouraging, we recognize the need for further research to confirm these benefits conclusively. Reduced depression Most Useful Review 1 people found this helpful I’ve been taking this for three months and feel it helps with my depression. |
 Nordic Naturals, Postnatal Omega-3, Lemon, 1,120 mg, 60 Soft Gels (560 mg per Soft Gel) | | |
Vitamin D3 improves depressive symptomsEffects of vitamin D supplementation on depression and some selected pro-inflammatory biomarkers: a double-blind randomized clinical trial. We conducted a double-blind randomized clinical trial to explore the effects of vitamin D3 supplementation on depression. Our study involved 56 adults with mild to moderate depression, who were assigned to either a vitamin D group or a placebo group. Over the course of eight weeks, the vitamin D group received a high dose of 50,000 IU cholecalciferol every two weeks, while the control group received a placebo.
After the treatment period, we observed that the participants who received the vitamin D3 experienced a significant reduction in depression severity, as measured by the Beck Depression Inventory-II. Interestingly, this improvement in mood occurred independently of any changes in inflammatory biomarkers like IL-1β, IL-6, and hs-CRP, which we also assessed during the study.
This indicates that while vitamin D supplementation may positively impact depressive symptoms, its effects are not directly linked to the inflammatory markers we evaluated. Our findings suggest that vitamin D3 could be a helpful addition to depression treatment strategies, particularly in individuals with low vitamin D levels. Mood improvement Most Useful Review 16 people found this helpful I have been taking it for twenty days now. My hair has improved, and my nervousness and lack of focus have eased. Symptoms of depression, anxiety, distraction, forgetfulness, and stammering have diminished by almost 80%. I hope this helps you. |
 NOW Foods, Folic Acid, 800 mcg, 250 Tablets | | |
Vitamin B12 shows no benefit for depressionAssessment of Vitamin B12 Efficacy on Cognitive Memory Function and Depressive Symptoms: A Systematic Review and Meta-Analysis. We assessed the effect of vitamin B12 supplementation on depressive symptoms by reviewing several randomized controlled trials (RCTs). Our analysis focused on participants who may experience mild cognitive impairment, an area where low vitamin B12 levels could potentially raise the risk of depression.
After a thorough examination of studies, we found that the included trials did not support a significant benefit of vitamin B12 for alleviating depressive symptoms. In our evaluation of three studies focusing specifically on depression, the average difference in symptoms was negligible, indicating no real effect.
This outcome reflects that while vitamin B12 is essential for various bodily functions, its role in improving mood and reducing depression symptoms may not be as effective as some might hope. Further exploration is still warranted to better understand the contexts in which vitamin B12 could be beneficial. Less severe illness Most Useful Review 88 people found this helpful After using this vitamin for over a year, I've noticed a significant improvement in my quality of life. Not only do I feel healthier and get sick less often, but it has noticeably improved my mood. Given my family history of depression, I am very grateful for this change. |
 Life Extension, Optimized Folate, 1,700 mcg DFE, 100 Vegetarian Tablets | | |
Folic acid aids depression treatmentFolate as adjunct therapy to SSRI/SNRI for major depressive disorder: Systematic review & meta-analysis. We examined the effects of folic acid as an add-on treatment for major depression alongside traditional medications like SSRIs and SNRIs. After reviewing six randomized control trials, we found that patients receiving folic acid showed better progress.
Specifically, their depression scores improved significantly, with higher response and remission rates as well. This suggests that adding folic acid might enhance the benefits of standard depression therapies, giving hope to those looking for more effective treatment options. Significant improvement Most Useful Review 23 people found this helpful The depression killer! I have experienced depression all my life. Methyl folate has significantly aided me in overcoming depression and mood swings. Its potency surpasses most other products, which is sufficient to do the job. Additionally, I take choline for better nerve transmission and exercise daily, yielding numerous benefits that I can't list fully here. My doctor was astonished by my progress. I hope this assists you in your journey. |
 21st Century, Folic Acid, 400 mcg, 250 Easy to Swallow Tablets | | |
Folic acid aids depression treatmentFolate as adjunct therapy to SSRI/SNRI for major depressive disorder: Systematic review & meta-analysis. We examined the effects of folic acid as an add-on treatment for major depression alongside traditional medications like SSRIs and SNRIs. After reviewing six randomized control trials, we found that patients receiving folic acid showed better progress.
Specifically, their depression scores improved significantly, with higher response and remission rates as well. This suggests that adding folic acid might enhance the benefits of standard depression therapies, giving hope to those looking for more effective treatment options. Better well-being Most Useful Review 100 people found this helpful I take folic acid to combat my depression. My well-being and mood have steadily improved. I appreciate the results, especially as I had previously lost hope that anything would help me. |
 Jarrow Formulas, Vegan Methyl Folate, Extra Strength, 400 mcg, 60 Veggie Capsules | | |
Folic acid aids depression treatmentFolate as adjunct therapy to SSRI/SNRI for major depressive disorder: Systematic review & meta-analysis. We examined the effects of folic acid as an add-on treatment for major depression alongside traditional medications like SSRIs and SNRIs. After reviewing six randomized control trials, we found that patients receiving folic acid showed better progress.
Specifically, their depression scores improved significantly, with higher response and remission rates as well. This suggests that adding folic acid might enhance the benefits of standard depression therapies, giving hope to those looking for more effective treatment options. Potential depression aid Most Useful Review 86 people found this helpful Methylfolate, or (6S)-5-MTHF, is the most effective form of folate, easily absorbed and critical for human health. It helps control homocysteine levels, supports cell growth, and reduces risks of developmental defects in infants. Methylfolate also positively influences cognitive functions, making it valuable for depression treatment. Studies show it can lower homocysteine levels, which, when elevated, is linked to cardiovascular diseases. It's crucial to choose methylfolate over standard folic acid, which is poorly absorbed and can hinder essential nutrient absorption from food. |
 Solaray, Timed Release Vitamin C with Rose Hips & Acerola, 1,000 mg, 250 Tablets | | |
Vitamin C intake linked to depressionAssociation of dietary vitamin C intake with depression in adults: A cross-sectional study of NHANES from 2005 to 2020. This study aimed to understand how dietary vitamin C affects depression in adults. By analyzing data from the National Health and Nutrition Examination Survey spanning from 2005 to 2020, we focused on the relationship between vitamin C intake and depression levels among 38,157 participants.
Our findings revealed that individuals who consumed higher amounts of vitamin C had lower odds of experiencing depression. Specifically, those in the higher intake quartiles showed significantly reduced odds compared to those with the lowest intake. Interestingly, we discovered an L-shaped curve representing the relationship between vitamin C and depression, suggesting that while increased intake was beneficial up to a certain point (around 93.61 mg), higher consumption did not yield additional benefits.
While our results are promising, it's crucial to note that this was a cross-sectional study, meaning we cannot definitively claim that vitamin C intake causes changes in depression. Additionally, other factors might have influenced these associations, which we couldn't fully control for.
Overall, this research provides intriguing evidence of the potential role that dietary vitamin C might play in alleviating depressive symptoms, especially for those consuming lower amounts. Excellent vitamin escape Most Useful Review I've been taking vitamin C for three years, prompted by Dr. Tokumi Fujikawa's recommendations. Previously, I often caught colds and had a sore throat, but now I haven’t been ill for two years. This excellent vitamin has aided in alleviating my depression and functional dyspepsia, particularly relevant given my age. I comfortably take two tablets each morning and evening. Though swallowing them was tricky at first, it became easier, and now I consider it essential for immunity, especially during these times. |
 NOW Foods, C-1000, 250 Tablets | | |
Vitamin C intake linked to depressionAssociation of dietary vitamin C intake with depression in adults: A cross-sectional study of NHANES from 2005 to 2020. This study aimed to understand how dietary vitamin C affects depression in adults. By analyzing data from the National Health and Nutrition Examination Survey spanning from 2005 to 2020, we focused on the relationship between vitamin C intake and depression levels among 38,157 participants.
Our findings revealed that individuals who consumed higher amounts of vitamin C had lower odds of experiencing depression. Specifically, those in the higher intake quartiles showed significantly reduced odds compared to those with the lowest intake. Interestingly, we discovered an L-shaped curve representing the relationship between vitamin C and depression, suggesting that while increased intake was beneficial up to a certain point (around 93.61 mg), higher consumption did not yield additional benefits.
While our results are promising, it's crucial to note that this was a cross-sectional study, meaning we cannot definitively claim that vitamin C intake causes changes in depression. Additionally, other factors might have influenced these associations, which we couldn't fully control for.
Overall, this research provides intriguing evidence of the potential role that dietary vitamin C might play in alleviating depressive symptoms, especially for those consuming lower amounts. Improved mood stability Most Useful Review I love that it's natural and it doesn't taste bad at all! A little citrusy, but that's understandable. Although the pills are larger, they are manageable. I take it as an addition to help with my depression, and it has made a significant difference! I feel much happier, and my moods have become far more stable. I will definitely continue to purchase this! :) |
 Life Extension, Vitamins D and K with Sea-Iodine, 60 Capsules | | |
Vitamin D3 improves depressive symptomsEffects of vitamin D supplementation on depression and some selected pro-inflammatory biomarkers: a double-blind randomized clinical trial. We conducted a double-blind randomized clinical trial to explore the effects of vitamin D3 supplementation on depression. Our study involved 56 adults with mild to moderate depression, who were assigned to either a vitamin D group or a placebo group. Over the course of eight weeks, the vitamin D group received a high dose of 50,000 IU cholecalciferol every two weeks, while the control group received a placebo.
After the treatment period, we observed that the participants who received the vitamin D3 experienced a significant reduction in depression severity, as measured by the Beck Depression Inventory-II. Interestingly, this improvement in mood occurred independently of any changes in inflammatory biomarkers like IL-1β, IL-6, and hs-CRP, which we also assessed during the study.
This indicates that while vitamin D supplementation may positively impact depressive symptoms, its effects are not directly linked to the inflammatory markers we evaluated. Our findings suggest that vitamin D3 could be a helpful addition to depression treatment strategies, particularly in individuals with low vitamin D levels. Depression relief Most Useful Review I ordered this for my mother, and she became more energetic in the mornings; her depression has subsided. |
 NOW Foods, E-400 with Mixed Tocopherols, 268 mg (400 IU), 250 Softgels | | |
Effective for PMS Most Useful Review 1 people found this helpful Since last year, I've been struggling with severe depression alongside PMS and PMDD. I've been practising megavitamin therapy, taking five tablets each morning. The tocopherol seems beneficial, and while the tablets are large, they're easy to swallow. I believe this therapy is effective in addressing my depression. Cured my depression Most Useful Review Since I began megavitamin therapy, my depression has lifted, and I feel less fatigued, with improved skin. It's challenging to obtain sufficient vitamin E from food, which is why this supplement is crucial. Everything about this product, from its content to its quality, is excellent. I wholeheartedly recommend it. |
 NOW Foods, E-400, 268 mg (400 IU), 250 Softgels | | |
Effective for depression Most Useful Review 11 people found this helpful They have a distinct lemon colour and shape, roughly 1 cm in length. The smaller grains are easy to swallow without risk of choking. Since I've been taking this with magnesium, I've noticed minimal effects from Mother of Life, but it has been beneficial for my depression and frustration. I feel generally more comfortable each day without the ups and downs. Reduced menstrual cramps Most Useful Review 8 people found this helpful Practising the Fujikawa method is crucial. Initially, I noticed effects using one tablet daily, but increasing to two tablets eradicated my severe menstrual cramps without needing painkillers. My depression has also lessened. Sharing this with family and friends yielded similar results. The soft capsules are easy to swallow, so I highly recommend them! |
 NOW Foods, MK-7 Vitamin K-2 , 100 mcg, 120 Veg Capsules | | |
Elevated mood Most Useful Review Excellent quality. I purchased this product a long time ago, as it is essential to supplement with vitamin D3 and vitamin K2 every winter. It is well-known that MK7 is the best choice, and the ingredients in this brand signify quality, which is why I always opt for it. The benefits are remarkable; my mood improves significantly when using vitamin D3 and K2, leaving no room for depression during the season. Helps depression Most Useful Review I take this product with NOW D3 and have been doing so for quite some time. It has significantly helped me with my depression when taking both together. |
 NOW Foods, Vitamin A, 10,000 IU, 100 Softgels | | |
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 Solgar, Choline/Inositol, 100 Vegetable Capsules | | |
Myo-inositol: Depression treatment potentialCyclitols: From Basic Understanding to Their Association with Neurodegeneration. We explored the potential of inositol, particularly Myo-inositol (MI), as a treatment option for depression, especially in individuals dealing with neurodegenerative disorders. The literature suggests that MI and its derivatives are vital in various cellular functions, including signal transmission and osmoregulation.
While our focus was primarily on neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's, the interesting twist is how inositol may also help alleviate depressive symptoms. Research indicates that dietary supplementation with MI can have promising effects on mental health, suggesting a connection between inositol levels and mood enhancement.
However, despite the encouraging findings, much remains to be discovered. The relationship between inositol treatment and its effectiveness in treating depression is still being closely examined. Overall, it appears that while inositol shows potential, more comprehensive studies are needed to fully understand its benefits and mechanisms related specifically to depression. Reduced anxiety significantly Most Useful Review 29 people found this helpful Wonderful! Verified helps! I took 2 capsules a day once. After just 2 weeks, I noted a significant reduction in anxiety and panic attacks. After 1 month of taking it, my depression and the resulting apathy diminished considerably. The medication works gently without sudden fluctuations. I combined it with ginkgo biloba, which enhanced my clarity of thought. Additionally, the choline in this product aids liver recovery. I trust Solgar, and this product has not let me down. |
 NOW Foods, Choline & Inositol, 100 Veg Capsules | | |
Myo-inositol: Depression treatment potentialCyclitols: From Basic Understanding to Their Association with Neurodegeneration. We explored the potential of inositol, particularly Myo-inositol (MI), as a treatment option for depression, especially in individuals dealing with neurodegenerative disorders. The literature suggests that MI and its derivatives are vital in various cellular functions, including signal transmission and osmoregulation.
While our focus was primarily on neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's, the interesting twist is how inositol may also help alleviate depressive symptoms. Research indicates that dietary supplementation with MI can have promising effects on mental health, suggesting a connection between inositol levels and mood enhancement.
However, despite the encouraging findings, much remains to be discovered. The relationship between inositol treatment and its effectiveness in treating depression is still being closely examined. Overall, it appears that while inositol shows potential, more comprehensive studies are needed to fully understand its benefits and mechanisms related specifically to depression. Relieved anxiety Most Useful Review Taking choline seems to have alleviated my depression. I no longer feel anxious without it. |
 NOW Foods, Inositol Capsules, 500 mg, 100 Veg Capsules | | |
Myo-inositol: Depression treatment potentialCyclitols: From Basic Understanding to Their Association with Neurodegeneration. We explored the potential of inositol, particularly Myo-inositol (MI), as a treatment option for depression, especially in individuals dealing with neurodegenerative disorders. The literature suggests that MI and its derivatives are vital in various cellular functions, including signal transmission and osmoregulation.
While our focus was primarily on neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's, the interesting twist is how inositol may also help alleviate depressive symptoms. Research indicates that dietary supplementation with MI can have promising effects on mental health, suggesting a connection between inositol levels and mood enhancement.
However, despite the encouraging findings, much remains to be discovered. The relationship between inositol treatment and its effectiveness in treating depression is still being closely examined. Overall, it appears that while inositol shows potential, more comprehensive studies are needed to fully understand its benefits and mechanisms related specifically to depression. Reduced panic Most Useful Review 93 people found this helpful I have struggled with depression and panic disorder, relying on prescribed medication. After starting Inositol, I was pleasantly surprised by its calming effects; I found myself able to go without my usual medications for the first time in ages. I remain cautious, yet hopeful for further progress. |
 Solgar, Methylcobalamin (Vitamin B12), 1,000 mcg, 60 Nuggets | | |
Vitamin B affects depression riskLow vitamin B but not folate is associated with incident depressive symptoms in community-dwelling older adults: a 4-year longitudinal study. We explored the connection between vitamin B levels and depression in older adults over four years. Our study followed nearly 3,850 participants and found that those with low blood levels of vitamin B were significantly more likely to report depressive symptoms. Specifically, individuals with low vitamin B had a 51% higher chance of developing depression compared to those with adequate levels.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults. Depression alleviated Most Useful Review 23 people found this helpful A beautiful product! To be brief, my depression has passed, and I have experienced less hair loss. |
 NOW Foods, B-12, 5,000 mcg, 60 Lozenges | | |
Vitamin B affects depression riskLow vitamin B but not folate is associated with incident depressive symptoms in community-dwelling older adults: a 4-year longitudinal study. We explored the connection between vitamin B levels and depression in older adults over four years. Our study followed nearly 3,850 participants and found that those with low blood levels of vitamin B were significantly more likely to report depressive symptoms. Specifically, individuals with low vitamin B had a 51% higher chance of developing depression compared to those with adequate levels.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults. Saved from depression Most Useful Review 3 people found this helpful The best product I have ever taken; it has saved me from depression and despondency. Nowadays, I feel spirited, and my nails are healthy and strong as they have never been. I would never want to be without this product. |
 Deva, Vegan B12 with Folic Acid & B6, Fast-Dissolve, 90 Tablets | | |
Vitamin B affects depression riskLow vitamin B but not folate is associated with incident depressive symptoms in community-dwelling older adults: a 4-year longitudinal study. We explored the connection between vitamin B levels and depression in older adults over four years. Our study followed nearly 3,850 participants and found that those with low blood levels of vitamin B were significantly more likely to report depressive symptoms. Specifically, individuals with low vitamin B had a 51% higher chance of developing depression compared to those with adequate levels.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults. Improves memory Most Useful Review 4 people found this helpful Vitamin B12 offers numerous benefits, including improvements in anaemia, fatigue, and depression. It is particularly vital for older adults, such as my mother, as it aids memory function; however, one should always consult a doctor when taking it. |
 Garden of Life, Vitamin Code, RAW B-12, 30 Vegan Capsules | | |
Vitamin B affects depression riskLow vitamin B but not folate is associated with incident depressive symptoms in community-dwelling older adults: a 4-year longitudinal study. We explored the connection between vitamin B levels and depression in older adults over four years. Our study followed nearly 3,850 participants and found that those with low blood levels of vitamin B were significantly more likely to report depressive symptoms. Specifically, individuals with low vitamin B had a 51% higher chance of developing depression compared to those with adequate levels.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults. Improved mood Most Useful Review 14 people found this helpful Amazing B12! This supplement has made a massive difference to my energy levels and mood swings. After taking it alongside a B-complex for just three days, I felt fantastic. I've struggled with severe depression for years, but these two supplements truly work for me. I take them with a fruit smoothie in the morning, and I can’t recommend them enough; simply awesome! |
 NOW Foods, B-12, 1,000 mcg, 100 Lozenges | | |
Vitamin B affects depression riskLow vitamin B but not folate is associated with incident depressive symptoms in community-dwelling older adults: a 4-year longitudinal study. We explored the connection between vitamin B levels and depression in older adults over four years. Our study followed nearly 3,850 participants and found that those with low blood levels of vitamin B were significantly more likely to report depressive symptoms. Specifically, individuals with low vitamin B had a 51% higher chance of developing depression compared to those with adequate levels.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults. Supports memory Most Useful Review 1 people found this helpful Vitamin B12 is crucial for cell division and nerve maintenance. A deficiency can lead to numerous cognitive disorders and heightened depression. It's essential for maintaining overall mental health and energy levels. |
 Solgar, Liquid B-12, Sublingual, 2,000 mcg, 2 fl oz (59 ml) | | |
Vitamin B affects depression riskLow vitamin B but not folate is associated with incident depressive symptoms in community-dwelling older adults: a 4-year longitudinal study. We explored the connection between vitamin B levels and depression in older adults over four years. Our study followed nearly 3,850 participants and found that those with low blood levels of vitamin B were significantly more likely to report depressive symptoms. Specifically, individuals with low vitamin B had a 51% higher chance of developing depression compared to those with adequate levels.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults. Energy boost for depression Most Useful Review Solgar's liquid vitamin B12 is outstanding; it energises quickly, is beneficial for the nervous system, and helps with depression. I wholeheartedly recommend it! |
 Jarrow Formulas, Methyl B-12, Extra Strength, Lemon, 1,000 mcg, 100 Chewable Tablets | | |
Vitamin B affects depression riskLow vitamin B but not folate is associated with incident depressive symptoms in community-dwelling older adults: a 4-year longitudinal study. We explored the connection between vitamin B levels and depression in older adults over four years. Our study followed nearly 3,850 participants and found that those with low blood levels of vitamin B were significantly more likely to report depressive symptoms. Specifically, individuals with low vitamin B had a 51% higher chance of developing depression compared to those with adequate levels.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults. Supports emotional stability Most Useful Review 69 people found this helpful Methylcobalamin has shown effects for me! As a nerve vitamin, it assists in nerve repair and regeneration. I discovered it helps with my moods, particularly with depression. I believe it can benefit empaths and those sensitive to their surroundings when paired with vitamin C. |
 Natrol, Vitamin B-12, Fast Dissolve, Maximum Strength, Strawberry, 5,000 mcg, 100 Tablets | | |
Vitamin B affects depression riskLow vitamin B but not folate is associated with incident depressive symptoms in community-dwelling older adults: a 4-year longitudinal study. We explored the connection between vitamin B levels and depression in older adults over four years. Our study followed nearly 3,850 participants and found that those with low blood levels of vitamin B were significantly more likely to report depressive symptoms. Specifically, individuals with low vitamin B had a 51% higher chance of developing depression compared to those with adequate levels.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults. Decreased fatigue Most Useful Review I felt quite fatigued and depressed until I started taking this supplement; now, I feel much better. I’ve read that EA is beneficial but ensure to buy only from I Herb, not other retailers. |
 21st Century, B-12, Cherry, 2,500 mcg, 110 Sublingual Tablets | | |
Vitamin B affects depression riskLow vitamin B but not folate is associated with incident depressive symptoms in community-dwelling older adults: a 4-year longitudinal study. We explored the connection between vitamin B levels and depression in older adults over four years. Our study followed nearly 3,850 participants and found that those with low blood levels of vitamin B were significantly more likely to report depressive symptoms. Specifically, individuals with low vitamin B had a 51% higher chance of developing depression compared to those with adequate levels.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults. Resolved depression Most Useful Review 1 people found this helpful Excellent! B12 is a fantastic product that I take alongside folic acid and I'm now fine with depression. I would 100% recommend it. The quality and price are great. It has a pleasant raspberry flavour and aroma. The small pills are easy to swallow. Many thanks to the iHerb team. |
 NOW Foods, Methyl B-12, 1,000 mcg, 100 Lozenges | | |
Vitamin B affects depression riskLow vitamin B but not folate is associated with incident depressive symptoms in community-dwelling older adults: a 4-year longitudinal study. We explored the connection between vitamin B levels and depression in older adults over four years. Our study followed nearly 3,850 participants and found that those with low blood levels of vitamin B were significantly more likely to report depressive symptoms. Specifically, individuals with low vitamin B had a 51% higher chance of developing depression compared to those with adequate levels.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults. Strengthens memory Most Useful Review 10 people found this helpful Forgetting information or people can indicate vitamin B12 deficiency. Adequate amounts support memory and are especially recommended for students. Research indicates that a deficiency raises the risk of developing Alzheimer's, highlighting its importance for brain health and focus. B12 may also benefit those prone to depression and mood disorders. |
 Doctor's Best, Fully Active B12, 1,500 mcg, 180 Veggie Caps | | |
Vitamin B affects depression riskLow vitamin B but not folate is associated with incident depressive symptoms in community-dwelling older adults: a 4-year longitudinal study. We explored the connection between vitamin B levels and depression in older adults over four years. Our study followed nearly 3,850 participants and found that those with low blood levels of vitamin B were significantly more likely to report depressive symptoms. Specifically, individuals with low vitamin B had a 51% higher chance of developing depression compared to those with adequate levels.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults. Reduced depressive symptoms Most Useful Review 4 people found this helpful After a month, my symptoms of vitamin B12 deficiency, including depression, significantly decreased. I experienced no allergies or complications. It is safe for me and reasonably priced. |
 Garden of Life, MyKind Organics, B-12 Organic Spray, Raspberry, 2 fl oz (58 ml) | | |
Vitamin B affects depression riskLow vitamin B but not folate is associated with incident depressive symptoms in community-dwelling older adults: a 4-year longitudinal study. We explored the connection between vitamin B levels and depression in older adults over four years. Our study followed nearly 3,850 participants and found that those with low blood levels of vitamin B were significantly more likely to report depressive symptoms. Specifically, individuals with low vitamin B had a 51% higher chance of developing depression compared to those with adequate levels.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults. Postpartum support noted Most Useful Review The cast form is suitable for both children and adults, and it helped me avoid postpartum depression. Take strictly as your doctor advises! |
 Sports Research, Omega-3 Fish Oil, Triple Strength , 30 Softgels | | |
Eicosapentaenoic acid may reduce depressionThe Efficacy of Omega-3 Fatty Acids as the Monotherapy for Depression: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. We conducted a study to explore the effectiveness of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, in treating major depressive disorder (MDD). Over the course of 12 weeks, 60 participants suffering from MDD were divided into two groups: one received 3.2 grams of EPA daily, while the other group was given a placebo, which was soybean oil.
Throughout the study, we assessed the severity of depression using the Hamilton Rating Scale for Depression (HRSD). What we found was promising. The group taking EPA experienced significantly lower HRSD scores at various checkpoints—specifically at weeks 4, 6, 8, and 12—indicating a reduction in depressive symptoms. Although the rates of remission and response were higher in the EPA group compared to the placebo group, these findings did not achieve statistical significance.
Overall, while EPA shows potential as a treatment for depression, further research is needed to solidify its role. Our findings suggest that it may be an alternative option for MDD patients seeking additional treatment pathways. Supports depression relief Most Useful Review 4 people found this helpful Distinguished Reduces the risk of depression and anxiety, enhancing brain function significantly for concentration and memory. Omega 3 also promotes healthy skin and hair. These pills help reduce appetite during main meals, aiding weight loss likely through regulating serotonin, the hormone that controls appetite. This control can significantly reduce depression symptoms. Quality ingredients and excellent taste. |
 Doctor's Best, High Absorption CoQ10 with BioPerine®, 100 mg, 120 Veggie Caps | | |
Q10 alleviates post-stroke depressionChronic treatment with coenzyme Q10 mitigates the behavioral dysfunction of global cerebral ischemia/reperfusion injury in rats. We explored the effects of Coenzyme Q10 (Q10) on depression and cognitive deficits following global cerebral ischemia/reperfusion (I/R) injury in rats. In this study, we induced brain injury by blocking blood flow to both carotid arteries for 20 minutes. The rats then received Q10 at a dose of 200 mg/kg for six weeks.
The results illustrated that the I/R injury led to increased anxiety and depressive behaviors in the animals, alongside a noticeable decline in cognitive performance. Moreover, we found that the levels of brain-derived neurotrophic factor (BDNF) and the activity of superoxide dismutase (SOD) were reduced after the stroke.
Upon treating with Q10, we observed significant improvements. The treatment not only decreased brain swelling but also lessened anxiety and depressive-like symptoms. Cognitive impairments improved as well, with increased BDNF levels and SOD activity in the brain tissues of the animals receiving Q10.
Ultimately, this study points to the potential benefits of Q10 supplementation in mitigating symptoms of depression and cognitive issues after a stroke. Supports depression relief Most Useful Review 9 people found this helpful Coenzyme Q10 is vital for energy production and has notably improved my well-being. After noticing its benefits, including reduced fatigue and enhanced mood, I’ve encouraged others to try it. My mother, who leads an unhealthy lifestyle, experienced a significant uplift in her energy levels and mood after taking it. It's an essential support for heart health and an effective remedy for depression. |
 Solgar, Vitamin D3 (Cholecalciferol), 125 mcg (5,000 IU), 240 Vegetable Capsules | | |
Vitamin D3 improves depressive symptomsEffects of vitamin D supplementation on depression and some selected pro-inflammatory biomarkers: a double-blind randomized clinical trial. We conducted a double-blind randomized clinical trial to explore the effects of vitamin D3 supplementation on depression. Our study involved 56 adults with mild to moderate depression, who were assigned to either a vitamin D group or a placebo group. Over the course of eight weeks, the vitamin D group received a high dose of 50,000 IU cholecalciferol every two weeks, while the control group received a placebo.
After the treatment period, we observed that the participants who received the vitamin D3 experienced a significant reduction in depression severity, as measured by the Beck Depression Inventory-II. Interestingly, this improvement in mood occurred independently of any changes in inflammatory biomarkers like IL-1β, IL-6, and hs-CRP, which we also assessed during the study.
This indicates that while vitamin D supplementation may positively impact depressive symptoms, its effects are not directly linked to the inflammatory markers we evaluated. Our findings suggest that vitamin D3 could be a helpful addition to depression treatment strategies, particularly in individuals with low vitamin D levels. Boosted energy Most Useful Review 1 people found this helpful The best vitamin D3! It strengthens the immune system, combats depression, and improves sleep, making one feel lively and energetic. After just a few days, I experienced an energy boost and found it easier to wake up. Since balancing my D3 levels with this product, I haven't caught a single cold. Truly an excellent result! |
 Life Extension, Vitamin D3, 125 mcg (5,000 IU), 60 Softgels | | |
Vitamin D3 improves depressive symptomsEffects of vitamin D supplementation on depression and some selected pro-inflammatory biomarkers: a double-blind randomized clinical trial. We conducted a double-blind randomized clinical trial to explore the effects of vitamin D3 supplementation on depression. Our study involved 56 adults with mild to moderate depression, who were assigned to either a vitamin D group or a placebo group. Over the course of eight weeks, the vitamin D group received a high dose of 50,000 IU cholecalciferol every two weeks, while the control group received a placebo.
After the treatment period, we observed that the participants who received the vitamin D3 experienced a significant reduction in depression severity, as measured by the Beck Depression Inventory-II. Interestingly, this improvement in mood occurred independently of any changes in inflammatory biomarkers like IL-1β, IL-6, and hs-CRP, which we also assessed during the study.
This indicates that while vitamin D supplementation may positively impact depressive symptoms, its effects are not directly linked to the inflammatory markers we evaluated. Our findings suggest that vitamin D3 could be a helpful addition to depression treatment strategies, particularly in individuals with low vitamin D levels. Magical remedy for energy Most Useful Review For me, this vitamin is a magical remedy. It combats depression and gives me the strength and energy to live fully, possibly addressing my vitamin D deficiency. |
 NOW Foods, Vitamin D-3, Max Potency, 50,000 IU, 50 Softgels | | |
Vitamin D3 improves depressive symptomsEffects of vitamin D supplementation on depression and some selected pro-inflammatory biomarkers: a double-blind randomized clinical trial. We conducted a double-blind randomized clinical trial to explore the effects of vitamin D3 supplementation on depression. Our study involved 56 adults with mild to moderate depression, who were assigned to either a vitamin D group or a placebo group. Over the course of eight weeks, the vitamin D group received a high dose of 50,000 IU cholecalciferol every two weeks, while the control group received a placebo.
After the treatment period, we observed that the participants who received the vitamin D3 experienced a significant reduction in depression severity, as measured by the Beck Depression Inventory-II. Interestingly, this improvement in mood occurred independently of any changes in inflammatory biomarkers like IL-1β, IL-6, and hs-CRP, which we also assessed during the study.
This indicates that while vitamin D supplementation may positively impact depressive symptoms, its effects are not directly linked to the inflammatory markers we evaluated. Our findings suggest that vitamin D3 could be a helpful addition to depression treatment strategies, particularly in individuals with low vitamin D levels. Enhanced immunity Most Useful Review 10 people found this helpful The most important vitamin for the body is vitamin D3, especially for those with immune issues, joint pain, and depression. As someone with rheumatoid arthritis, I find it crucial. It boosts immunity and alleviates psychological distress. It’s more effective than cortisone. Take it with a fatty meal and alongside vitamin K2 for better absorption. The capsules are tasteless, well-packaged, and a good value. I hope this helps you! Always be grateful for your condition. |
 NOW Foods, Vitamin D-3, 400 IU, 180 Softgels | | |
Vitamin D3 improves depressive symptomsEffects of vitamin D supplementation on depression and some selected pro-inflammatory biomarkers: a double-blind randomized clinical trial. We conducted a double-blind randomized clinical trial to explore the effects of vitamin D3 supplementation on depression. Our study involved 56 adults with mild to moderate depression, who were assigned to either a vitamin D group or a placebo group. Over the course of eight weeks, the vitamin D group received a high dose of 50,000 IU cholecalciferol every two weeks, while the control group received a placebo.
After the treatment period, we observed that the participants who received the vitamin D3 experienced a significant reduction in depression severity, as measured by the Beck Depression Inventory-II. Interestingly, this improvement in mood occurred independently of any changes in inflammatory biomarkers like IL-1β, IL-6, and hs-CRP, which we also assessed during the study.
This indicates that while vitamin D supplementation may positively impact depressive symptoms, its effects are not directly linked to the inflammatory markers we evaluated. Our findings suggest that vitamin D3 could be a helpful addition to depression treatment strategies, particularly in individuals with low vitamin D levels. Avoided seasonal depression Most Useful Review 2 people found this helpful I find Cospa very effective, especially during times when sun exposure is limited. I take it daily to prevent vitamin D deficiency and have successfully avoided seasonal depression. There are claims that vitamin D may also help combat COVID-19, which motivates me to take it regularly. The small capsule size is a minor drawback, but the ingredient quality is excellent. |
 NOW Foods, Chewable Vitamin D-3, Natural Fruit Flavor, 1,000 IU, 180 Chewables | | |
Vitamin D3 improves depressive symptomsEffects of vitamin D supplementation on depression and some selected pro-inflammatory biomarkers: a double-blind randomized clinical trial. We conducted a double-blind randomized clinical trial to explore the effects of vitamin D3 supplementation on depression. Our study involved 56 adults with mild to moderate depression, who were assigned to either a vitamin D group or a placebo group. Over the course of eight weeks, the vitamin D group received a high dose of 50,000 IU cholecalciferol every two weeks, while the control group received a placebo.
After the treatment period, we observed that the participants who received the vitamin D3 experienced a significant reduction in depression severity, as measured by the Beck Depression Inventory-II. Interestingly, this improvement in mood occurred independently of any changes in inflammatory biomarkers like IL-1β, IL-6, and hs-CRP, which we also assessed during the study.
This indicates that while vitamin D supplementation may positively impact depressive symptoms, its effects are not directly linked to the inflammatory markers we evaluated. Our findings suggest that vitamin D3 could be a helpful addition to depression treatment strategies, particularly in individuals with low vitamin D levels. Reduces depression Most Useful Review 2 people found this helpful The most useful purchase. If you live in Ukraine or Russia, this supplement is essential from October to April. It replenishes the deficiency of vitamin D, alleviates depression, and even improves skin appearance. I definitely recommend it. |
 Nature's Bounty, D3, 50 mcg (2,000 IU), 350 Rapid Release Softgels | | |
Vitamin D supports depression managementEffects of cholecalciferol supplementation on depressive symptoms, C-peptide, serotonin, and neurotrophin-3 in type 2 diabetes mellitus: A double-blind, randomized, placebo-controlled trial. Putranto R, Setiati S, Nasrun MW, Witjaksono F, Immanuel S, et al. Effects of cholecalciferol supplementation on depressive symptoms, C-peptide, serotonin, and neurotrophin-3 in type 2 diabetes mellitus: A double-blind, randomized, placebo-controlled trial. Narra J. 2024;4:e1342. doi:10.52225/narra.v4i3.1342 We conducted a double-blind, randomized, placebo-controlled trial to explore how cholecalciferol, a form of vitamin D, influences depressive symptoms in individuals suffering from type 2 diabetes mellitus (T2DM). This clinical study lasted for 12 weeks and involved participants who were either given a daily dose of 4000 IU of cholecalciferol or a placebo.
Throughout the study, we measured various factors, including the participants’ depression levels using the Beck Depression Inventory-II, as well as important biological markers like C-peptide, serotonin, and neurotrophin-3.
Our findings showed a significant reduction in depression scores among those taking cholecalciferol compared to the placebo group. Additionally, we observed a notable increase in C-peptide levels, which may indicate some metabolic benefits, although no significant changes were found in serotonin and neurotrophin-3 levels.
Ultimately, while cholecalciferol appears to alleviate mild to moderate depressive symptoms in T2DM patients through improved C-peptide levels, its impact on serotonin and neurotrophin-3 remains unclear. This highlights vitamin D as a potentially helpful option for managing depression alongside diabetes. Mood improvement noted Most Useful Review Currently, many doctors regard vitamin D3 as akin to hormones, as its deficiency can lead to severe consequences, including stress and persistent depression. It aids calcium, phosphorus, and magnesium absorption, crucial for bone health. Additionally, it enhances metabolic processes, uplifts mood, alleviates anxiety and neuropsychiatric disorders, and helps with insomnia. Due to limited sunlight throughout the year, my family and I take this vitamin, promoting a tranquil atmosphere at home. |
 Jarrow Formulas, Vitamin D3, 125 mcg (5,000 IU), 100 Softgels | | |
Vitamin D supports depression managementEffects of cholecalciferol supplementation on depressive symptoms, C-peptide, serotonin, and neurotrophin-3 in type 2 diabetes mellitus: A double-blind, randomized, placebo-controlled trial. Putranto R, Setiati S, Nasrun MW, Witjaksono F, Immanuel S, et al. Effects of cholecalciferol supplementation on depressive symptoms, C-peptide, serotonin, and neurotrophin-3 in type 2 diabetes mellitus: A double-blind, randomized, placebo-controlled trial. Narra J. 2024;4:e1342. doi:10.52225/narra.v4i3.1342 We conducted a double-blind, randomized, placebo-controlled trial to explore how cholecalciferol, a form of vitamin D, influences depressive symptoms in individuals suffering from type 2 diabetes mellitus (T2DM). This clinical study lasted for 12 weeks and involved participants who were either given a daily dose of 4000 IU of cholecalciferol or a placebo.
Throughout the study, we measured various factors, including the participants’ depression levels using the Beck Depression Inventory-II, as well as important biological markers like C-peptide, serotonin, and neurotrophin-3.
Our findings showed a significant reduction in depression scores among those taking cholecalciferol compared to the placebo group. Additionally, we observed a notable increase in C-peptide levels, which may indicate some metabolic benefits, although no significant changes were found in serotonin and neurotrophin-3 levels.
Ultimately, while cholecalciferol appears to alleviate mild to moderate depressive symptoms in T2DM patients through improved C-peptide levels, its impact on serotonin and neurotrophin-3 remains unclear. This highlights vitamin D as a potentially helpful option for managing depression alongside diabetes. Energy boost Most Useful Review 1 people found this helpful This supplement invigorates and significantly improves my mood! I experience heightened energy, a stable mood, and no autumn depression. It's more effective than D3 tablets for me! |
 Solgar, Vitamin D 3 (Cholecalciferol), 25 mcg (1,000 IU), 100 Softgels | | |
Vitamin D3 improves depressive symptomsEffects of vitamin D supplementation on depression and some selected pro-inflammatory biomarkers: a double-blind randomized clinical trial. We conducted a double-blind randomized clinical trial to explore the effects of vitamin D3 supplementation on depression. Our study involved 56 adults with mild to moderate depression, who were assigned to either a vitamin D group or a placebo group. Over the course of eight weeks, the vitamin D group received a high dose of 50,000 IU cholecalciferol every two weeks, while the control group received a placebo.
After the treatment period, we observed that the participants who received the vitamin D3 experienced a significant reduction in depression severity, as measured by the Beck Depression Inventory-II. Interestingly, this improvement in mood occurred independently of any changes in inflammatory biomarkers like IL-1β, IL-6, and hs-CRP, which we also assessed during the study.
This indicates that while vitamin D supplementation may positively impact depressive symptoms, its effects are not directly linked to the inflammatory markers we evaluated. Our findings suggest that vitamin D3 could be a helpful addition to depression treatment strategies, particularly in individuals with low vitamin D levels. Emotional support Most Useful Review 4 people found this helpful I believe it assisted our family during a challenging period. We took one capsule twice daily from December to mid-March. We initially felt drained and emotionally exhausted due to a significant family crisis. After starting the Solgar D3 and Omega California, I was surprised by the boost in my energy and mood by February, allowing me to return to work. |
 Superior Source, D3, Extra Strength, 125 mcg (5,000 IU), 100 MicroLingual® Instant Dissolve Tablets | | |
Vitamin D supports depression managementEffects of cholecalciferol supplementation on depressive symptoms, C-peptide, serotonin, and neurotrophin-3 in type 2 diabetes mellitus: A double-blind, randomized, placebo-controlled trial. Putranto R, Setiati S, Nasrun MW, Witjaksono F, Immanuel S, et al. Effects of cholecalciferol supplementation on depressive symptoms, C-peptide, serotonin, and neurotrophin-3 in type 2 diabetes mellitus: A double-blind, randomized, placebo-controlled trial. Narra J. 2024;4:e1342. doi:10.52225/narra.v4i3.1342 We conducted a double-blind, randomized, placebo-controlled trial to explore how cholecalciferol, a form of vitamin D, influences depressive symptoms in individuals suffering from type 2 diabetes mellitus (T2DM). This clinical study lasted for 12 weeks and involved participants who were either given a daily dose of 4000 IU of cholecalciferol or a placebo.
Throughout the study, we measured various factors, including the participants’ depression levels using the Beck Depression Inventory-II, as well as important biological markers like C-peptide, serotonin, and neurotrophin-3.
Our findings showed a significant reduction in depression scores among those taking cholecalciferol compared to the placebo group. Additionally, we observed a notable increase in C-peptide levels, which may indicate some metabolic benefits, although no significant changes were found in serotonin and neurotrophin-3 levels.
Ultimately, while cholecalciferol appears to alleviate mild to moderate depressive symptoms in T2DM patients through improved C-peptide levels, its impact on serotonin and neurotrophin-3 remains unclear. This highlights vitamin D as a potentially helpful option for managing depression alongside diabetes. Improves mood Most Useful Review Excellent! The small tablets dissolve well and the dosage is perfect for my children! Vitamin D3 has numerous health benefits; it strengthens bones, enhances immunity, and improves mood. It serves as a natural antidepressant by reducing the risk of depression and aiding sleep. We take it as a family, with different types for adults and children! |
 NOW Foods, Vitamin D-3, High Potency, 5,000 IU, 120 Softgels | | |
Vitamin D3 improves depressive symptomsEffects of vitamin D supplementation on depression and some selected pro-inflammatory biomarkers: a double-blind randomized clinical trial. We conducted a double-blind randomized clinical trial to explore the effects of vitamin D3 supplementation on depression. Our study involved 56 adults with mild to moderate depression, who were assigned to either a vitamin D group or a placebo group. Over the course of eight weeks, the vitamin D group received a high dose of 50,000 IU cholecalciferol every two weeks, while the control group received a placebo.
After the treatment period, we observed that the participants who received the vitamin D3 experienced a significant reduction in depression severity, as measured by the Beck Depression Inventory-II. Interestingly, this improvement in mood occurred independently of any changes in inflammatory biomarkers like IL-1β, IL-6, and hs-CRP, which we also assessed during the study.
This indicates that while vitamin D supplementation may positively impact depressive symptoms, its effects are not directly linked to the inflammatory markers we evaluated. Our findings suggest that vitamin D3 could be a helpful addition to depression treatment strategies, particularly in individuals with low vitamin D levels. Supports depression treatment Most Useful Review 120 people found this helpful Vitamin D regulates calcium and phosphorus absorption and enhances immunity, keeping skin youthful and reducing anxiety. With most people deficient, sunlight is insufficient, so supplementation is essential. NOW Vitamin D3 maintains optimal levels in the body. Always consult your doctor before use. |
 NOW Foods, Vegetarian Dry Vitamin D, 1,000 IU, 120 Veg Capsules | | |
Vitamin D supports depression managementEffects of cholecalciferol supplementation on depressive symptoms, C-peptide, serotonin, and neurotrophin-3 in type 2 diabetes mellitus: A double-blind, randomized, placebo-controlled trial. Putranto R, Setiati S, Nasrun MW, Witjaksono F, Immanuel S, et al. Effects of cholecalciferol supplementation on depressive symptoms, C-peptide, serotonin, and neurotrophin-3 in type 2 diabetes mellitus: A double-blind, randomized, placebo-controlled trial. Narra J. 2024;4:e1342. doi:10.52225/narra.v4i3.1342 We conducted a double-blind, randomized, placebo-controlled trial to explore how cholecalciferol, a form of vitamin D, influences depressive symptoms in individuals suffering from type 2 diabetes mellitus (T2DM). This clinical study lasted for 12 weeks and involved participants who were either given a daily dose of 4000 IU of cholecalciferol or a placebo.
Throughout the study, we measured various factors, including the participants’ depression levels using the Beck Depression Inventory-II, as well as important biological markers like C-peptide, serotonin, and neurotrophin-3.
Our findings showed a significant reduction in depression scores among those taking cholecalciferol compared to the placebo group. Additionally, we observed a notable increase in C-peptide levels, which may indicate some metabolic benefits, although no significant changes were found in serotonin and neurotrophin-3 levels.
Ultimately, while cholecalciferol appears to alleviate mild to moderate depressive symptoms in T2DM patients through improved C-peptide levels, its impact on serotonin and neurotrophin-3 remains unclear. This highlights vitamin D as a potentially helpful option for managing depression alongside diabetes. Essential winter item Most Useful Review In a country with minimal sunlight, vitamin D is crucial for me in winter. Since starting it in November, I haven't faced any physical or mental issues, suggesting it's effective. |
 Nature's Bounty, Calcium Magnesium Zinc with Vitamin D3, 100 Coated Caplets | | |
Vitamin D supports depression managementEffects of cholecalciferol supplementation on depressive symptoms, C-peptide, serotonin, and neurotrophin-3 in type 2 diabetes mellitus: A double-blind, randomized, placebo-controlled trial. Putranto R, Setiati S, Nasrun MW, Witjaksono F, Immanuel S, et al. Effects of cholecalciferol supplementation on depressive symptoms, C-peptide, serotonin, and neurotrophin-3 in type 2 diabetes mellitus: A double-blind, randomized, placebo-controlled trial. Narra J. 2024;4:e1342. doi:10.52225/narra.v4i3.1342 We conducted a double-blind, randomized, placebo-controlled trial to explore how cholecalciferol, a form of vitamin D, influences depressive symptoms in individuals suffering from type 2 diabetes mellitus (T2DM). This clinical study lasted for 12 weeks and involved participants who were either given a daily dose of 4000 IU of cholecalciferol or a placebo.
Throughout the study, we measured various factors, including the participants’ depression levels using the Beck Depression Inventory-II, as well as important biological markers like C-peptide, serotonin, and neurotrophin-3.
Our findings showed a significant reduction in depression scores among those taking cholecalciferol compared to the placebo group. Additionally, we observed a notable increase in C-peptide levels, which may indicate some metabolic benefits, although no significant changes were found in serotonin and neurotrophin-3 levels.
Ultimately, while cholecalciferol appears to alleviate mild to moderate depressive symptoms in T2DM patients through improved C-peptide levels, its impact on serotonin and neurotrophin-3 remains unclear. This highlights vitamin D as a potentially helpful option for managing depression alongside diabetes. Greater well-being achieved Most Useful Review Wonderful! This is like a dream. All signs of depression and fatigue are gone. I take it at night every day, and I feel fantastic. |
 Solgar, Calcium Magnesium with Vitamin D3, 300 Tablets | | |
Vitamin D3 improves depressive symptomsEffects of vitamin D supplementation on depression and some selected pro-inflammatory biomarkers: a double-blind randomized clinical trial. We conducted a double-blind randomized clinical trial to explore the effects of vitamin D3 supplementation on depression. Our study involved 56 adults with mild to moderate depression, who were assigned to either a vitamin D group or a placebo group. Over the course of eight weeks, the vitamin D group received a high dose of 50,000 IU cholecalciferol every two weeks, while the control group received a placebo.
After the treatment period, we observed that the participants who received the vitamin D3 experienced a significant reduction in depression severity, as measured by the Beck Depression Inventory-II. Interestingly, this improvement in mood occurred independently of any changes in inflammatory biomarkers like IL-1β, IL-6, and hs-CRP, which we also assessed during the study.
This indicates that while vitamin D supplementation may positively impact depressive symptoms, its effects are not directly linked to the inflammatory markers we evaluated. Our findings suggest that vitamin D3 could be a helpful addition to depression treatment strategies, particularly in individuals with low vitamin D levels. Great help Most Useful Review 3 people found this helpful Please take magnesium; it has significantly alleviated my depression. |
 NOW Foods, Calcium & Magnesium, 250 Tablets | | |
Magnesium intake reduces depression riskDietary Magnesium Intake in Relation to Depression in Adults: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis of Epidemiologic Studies. We conducted a systematic review and meta-analysis exploring how dietary magnesium (Mg) intake connects with depression among adults. By reviewing data from over 63,000 individuals, we found that those with the highest magnesium intake had a 34% lower chance of experiencing depression compared to those with the lowest intake.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk. Calmness achieved Most Useful Review 12 people found this helpful Calm improved! I began to feel much calmer, with no signs of depression. My husband is surprised by my reduced yelling. I highly recommend it. |
 NOW Foods, Double Strength DHA-500 Fish Oil, 180 Softgels | | |
DHA shows potential for depressionThe Efficacy of Omega-3 Fatty Acids as the Monotherapy for Depression: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. We conducted a study to find out whether docosahexaenoic acid (DHA), a type of omega-3 fatty acid, could effectively help those dealing with major depressive disorder (MDD). Over the course of 12 weeks, 60 participants were involved in a double-blind, placebo-controlled trial. They were divided into two groups: one received 3.2 grams of DHA daily, while the other group was given an equivalent amount of soybean oil as a placebo.
Throughout the study, we measured depression levels using the Hamilton Rating Scale for Depression (HRSD). Our results were intriguing—those taking the DHA showed significant improvements in their depression scores compared to the placebo group by weeks 4, 6, 8, and 12. While we noted that 26.7% of participants receiving DHA achieved remission by week 12, this was not statistically significant in comparison to the placebo group.
Overall, our findings support the idea that DHA may serve as a promising alternative treatment for individuals suffering from MDD. Although the results are encouraging, we recognize the need for further research to confirm these benefits conclusively. Improved memory function Most Useful Review 2 people found this helpful Breaking old habits can be challenging, especially when it comes to diet. My upbringing led to a lack of Omega-3, which resulted in poor memory and cognitive function. After incorporating DHA into my routine, my memory improved significantly, and I felt more alert. It also positively influenced my skin and hair. I intend to continue supplementing with DHA, especially due to its link to combating depression. |
 NOW Foods, Flush-Free Niacin, 250 mg, 180 Veg Capsules | | |
Myo-inositol: Depression treatment potentialCyclitols: From Basic Understanding to Their Association with Neurodegeneration. We explored the potential of inositol, particularly Myo-inositol (MI), as a treatment option for depression, especially in individuals dealing with neurodegenerative disorders. The literature suggests that MI and its derivatives are vital in various cellular functions, including signal transmission and osmoregulation.
While our focus was primarily on neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's, the interesting twist is how inositol may also help alleviate depressive symptoms. Research indicates that dietary supplementation with MI can have promising effects on mental health, suggesting a connection between inositol levels and mood enhancement.
However, despite the encouraging findings, much remains to be discovered. The relationship between inositol treatment and its effectiveness in treating depression is still being closely examined. Overall, it appears that while inositol shows potential, more comprehensive studies are needed to fully understand its benefits and mechanisms related specifically to depression. Improved sleep quality Most Useful Review 6 people found this helpful It's working! I'm taking one after dinner. I previously had terrible flushing with niacin, which is why I opted for this one. I'm sleeping better than before, and I'm less depressed. I've been on medication for over 20 years due to recurrent depression, yet I'm told I'm fine. Since megavitamin therapy is a lengthy process and encompasses various supplements aside from niacin, I plan to stick with this for the time being. |
 NOW Foods, B-100, 100 Veg Capsules | | |
Calming effects Most Useful Review 1 people found this helpful Amid issues at work and my son's first-grade challenges, I found myself on the verge of a nervous breakdown during the relentless pandemic. This drug saved me; I became much calmer, and trivial matters no longer felt overwhelming. I recommend it for maintaining and treating the nervous system. Increased energy Most Useful Review Recently, I suffered from muscle weakness, apathy, and depression, which seemed to arise from a significant deficiency of B vitamins. After my doctor recommended this complex, it really helped. The high dosages provided my body with energy and strength; it truly works, and I can highly recommend it! |
 Natrol, Biotin, 10,000 mcg, 200 Tablets | | |
Enhanced mood Most Useful Review 90 people found this helpful I've taken this vitamin for several months now, and it has been excellent. I take it daily to maintain my health, and I've seen improvements not only in my immunity but also in my mood, which is fantastic given my battle with depression. Mood improvement Most Useful Review 105 people found this helpful Excellent! My health has improved significantly; I feel energised and no longer suffer from mood swings or depression. This supplement is easy to take, and I recommend it to anyone seeking a natural way to enhance their health. |
 Solgar, Folate, 1,333 mcg, 100 Tablets (1,333 mcg DFE per Tablet) | | |
Folate's role in depression treatmentFolate supplementation as a beneficial add-on treatment in relieving depressive symptoms: A meta-analysis of meta-analyses. We conducted an umbrella meta-analysis to explore how folate affects depression. By sifting through various studies up to October 2023 from multiple databases like PubMed and Scopus, we wanted to find a clear answer regarding folate supplementation's role in alleviating depressive symptoms.
Our analysis included 11 relevant studies, out of which 8 underwent a quantitative review. The findings were promising: folate supplementation showed a significant reduction in depressive symptoms, with results suggesting an effect size that indicates moderate improvement. Specifically, the standardized mean difference was -0.42, and the weighted mean difference was -3.20, demonstrating a notable benefit with very little variability between studies.
Additionally, we found that those with low folate levels had a 35% higher chance of experiencing depression compared to their counterparts with adequate levels. This suggests a strong link between folate insufficiency and depressive symptoms.
Overall, our findings support the idea that folate supplementation could be an effective adjunct treatment when combined with standard depression therapies, providing individuals with another tool to manage their mental health. Improves mood significantly Most Useful Review 25 people found this helpful Totally satisfied. A neurologist recommended this product alongside Methyl B. I noticed a significant improvement in my overall wellbeing, particularly in sleep quality and my bouts of depression and anxiety, which I no longer experience. |
 Life Extension, BioActive, Folate & Vitamin B12, 90 Vegetarian Capsules | | |
Vitamin B12 shows no benefit for depressionAssessment of Vitamin B12 Efficacy on Cognitive Memory Function and Depressive Symptoms: A Systematic Review and Meta-Analysis. We assessed the effect of vitamin B12 supplementation on depressive symptoms by reviewing several randomized controlled trials (RCTs). Our analysis focused on participants who may experience mild cognitive impairment, an area where low vitamin B12 levels could potentially raise the risk of depression.
After a thorough examination of studies, we found that the included trials did not support a significant benefit of vitamin B12 for alleviating depressive symptoms. In our evaluation of three studies focusing specifically on depression, the average difference in symptoms was negligible, indicating no real effect.
This outcome reflects that while vitamin B12 is essential for various bodily functions, its role in improving mood and reducing depression symptoms may not be as effective as some might hope. Further exploration is still warranted to better understand the contexts in which vitamin B12 could be beneficial. Fights depression effectively Most Useful Review 50 people found this helpful EXCELLENT RESULT! If you consume little fresh greens and spinach, this supplement is essential. The folic acid here is vital for women’s health, supporting all organs, revitalising the cardiovascular system, and aiding in youthfulness. Vitamin B12, combined with folic acid, is effective against depression, fatigue, and irritability. These vitamins are interconnected, so it's best to take them together. I highly recommend this product! Thank you very much for your recommendation! |
 NOW Foods, B-1, 100 mg, 100 Tablets | | |
Anxiety management Most Useful Review 7 people found this helpful This vitamin is fantastic for alleviating depression! I use it alongside other supplements to help with anxiety and panic. Depression improvement Most Useful Review 6 people found this helpful This vitamin is excellent for fighting depression. I've been giving half a tablet to my son with Autism for years and it’s one of the key vitamins that has alleviated his depressive symptoms. |
 Jarrow Formulas, Pantothenic Acid B5, 500 mg, 100 Veggie Caps | | |
Calcium's role in depression exploredAssessment of the Correlation Between Unipolar and Bipolar Depression, Calcium Levels, Thyroid Function, and Inflammatory Markers: A Pilot Cross-Sectional Study. We aimed to investigate the connection between calcium levels and depression, specifically comparing unipolar and bipolar disorders. In the course of our pilot study, we enrolled 36 patients admitted to the University of Insubria Psychiatric Unit, who completed various psychological assessments to gauge their mental health.
Our findings revealed a noteworthy association between calcium levels and bipolar depression. We observed significant correlations not only between calcium and depressive symptoms, but also with inflammation markers like CRP (C-reactive protein). This indicates a possible relationship where lower calcium levels may relate to more severe symptoms in individuals with bipolar disorder.
While these associations are intriguing, it's important to note that we did not isolate the effects of calcium treatment itself on depressive symptoms. Therefore, while our results push the conversation forward regarding the role of calcium in mental health, they do not establish that calcium treatment is definitively beneficial for those struggling with depression.
Further research is essential to deepen our understanding of how inflammatory markers like calcium may contribute to different forms of depression. Our study highlights a pathway for future exploration into targeted therapeutic strategies that could help in treating these complex mood disorders more effectively. Relieves irritability Most Useful Review 24 people found this helpful I sought help for depression and burnout and learned I had a significant vitamin B5 deficiency. Pantothenic acid supports many body functions, including energy and hormone production. Its absence can lead to fatigue, irritability, and depression. Trusting my doctor's recommendation, I chose Jarrow Formulas for its quality. Taking one capsule daily has made a huge difference. I feel more energetic and hopeful since starting it. |
 Himalaya, Organic Ashwagandha, 60 Caplets | | |
DHA shows potential for depressionThe Efficacy of Omega-3 Fatty Acids as the Monotherapy for Depression: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. We conducted a study to find out whether docosahexaenoic acid (DHA), a type of omega-3 fatty acid, could effectively help those dealing with major depressive disorder (MDD). Over the course of 12 weeks, 60 participants were involved in a double-blind, placebo-controlled trial. They were divided into two groups: one received 3.2 grams of DHA daily, while the other group was given an equivalent amount of soybean oil as a placebo.
Throughout the study, we measured depression levels using the Hamilton Rating Scale for Depression (HRSD). Our results were intriguing—those taking the DHA showed significant improvements in their depression scores compared to the placebo group by weeks 4, 6, 8, and 12. While we noted that 26.7% of participants receiving DHA achieved remission by week 12, this was not statistically significant in comparison to the placebo group.
Overall, our findings support the idea that DHA may serve as a promising alternative treatment for individuals suffering from MDD. Although the results are encouraging, we recognize the need for further research to confirm these benefits conclusively. Increased energy Most Useful Review 21 people found this helpful I was amazed by my personal results. After a week of taking one caplet daily, my energy level noticeably increased, and my long-standing low-grade depression vanished. Research showed it balanced my hormones, and my daughter also experienced emotional stability. I'm 56 and lead a very healthy lifestyle. |
 NOW Foods, Niacin, Flush-Free, Double Strength, 500 mg, 180 Veg Capsules | | |
Myo-inositol: Depression treatment potentialCyclitols: From Basic Understanding to Their Association with Neurodegeneration. We explored the potential of inositol, particularly Myo-inositol (MI), as a treatment option for depression, especially in individuals dealing with neurodegenerative disorders. The literature suggests that MI and its derivatives are vital in various cellular functions, including signal transmission and osmoregulation.
While our focus was primarily on neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's, the interesting twist is how inositol may also help alleviate depressive symptoms. Research indicates that dietary supplementation with MI can have promising effects on mental health, suggesting a connection between inositol levels and mood enhancement.
However, despite the encouraging findings, much remains to be discovered. The relationship between inositol treatment and its effectiveness in treating depression is still being closely examined. Overall, it appears that while inositol shows potential, more comprehensive studies are needed to fully understand its benefits and mechanisms related specifically to depression. Effective treatment Most Useful Review 3 people found this helpful It's great for managing depression, and being flush-free makes it even more comfortable to take. |
 Gaia Herbs, Adrenal Health®, Daily Support, 60 Vegan Liquid Phyto-Caps | | |
Improved mood and calmness Most Useful Review 136 people found this helpful Believe me, this is a miracle! I had long-term postpartum depression for five years, raising three children without help. These capsules have truly made a significant difference! I took two in the morning after breakfast and another in the afternoon. There are absolutely no withdrawal symptoms! I feel revitalised and healthy! Stress no longer bothers me, and I'm calm, balanced, and collected. I've stopped shouting at the children and now dance and laugh with them. My husband and I aren't arguing anymore! Give it a try; you might love it too! Eliminated brain fog Most Useful Review 3 people found this helpful I used this five years ago to relieve stress, and it worked. Recently, I've struggled with sleep due to stress, making mornings tough. After taking Adrenal Health again, I found that I woke up refreshed, and the symptoms of morning brain fog had disappeared. My mild depression has also lifted. I plan to order again soon; the packaging and delivery were excellent. |
 NOW Foods, Super Omega 3-6-9, 1,200 mg, 90 Softgels | | |
Improved wellbeing Most Useful Review 150 people found this helpful Excellent! My overall health has improved, I now have more stamina and feel much more energised. I no longer experience mood swings or depression. This supplement is easy to take, and I recommend it to anyone seeking a natural way to enhance their health. Fights depression Most Useful Review 3 people found this helpful Omega-3 is essential for fighting anxiety and depression and reducing heart issues. Frankly, it’s a product that I cannot do without. |
 Solgar, Omega 3-6-9, 1,300 mg, 120 Softgels | | |
Boosts health significantly Most Useful Review 12 people found this helpful Excellent Omega from a reliable manufacturer. I regularly take omega acids, believing they are essential for the body, influencing almost all organs and systems. Due to natural foods, we do not receive sufficient amounts. This complex includes Omega from both animal and vegetable sources. Although the manufacturer recommends three capsules a day, I take two. My health and mood have improved significantly; I no longer experience the winter depression that used to trouble me. Moreover, I find comfort in knowing this supplement aids my cardiovascular health. Enhances overall functioning Most Useful Review Omega-3-6-9 is crucial for proper body function. Thanks to fish oil, it increases blood vessel elasticity, reduces the risk of heart attacks, and supports joint health. It also improves the central nervous system and brain functions, slows the aging process, and enhances mood, alleviating depression, irritability, and fatigue. |
 New Chapter, Perfect Postnatal Multivitamin, 192 Vegetarian Tablets | | |
No more depression Most Useful Review 1 people found this helpful Upon leaving the hospital, I started taking these vitamins. Thanks to them, I haven't experienced any depression or excessive fatigue from lack of sleep. They are somewhat expensive, but worth it. Psychological improvement Most Useful Review After giving birth, I advise every woman to take these vitamins immediately. I ordered them late, so they arrived a week after childbirth. You can't imagine the difference in my psychological state; I had depression but noticed an improvement after starting the vitamins. They're also beneficial for breastfeeding, ensuring both mother and baby receive essential vitamins. |
 NOW Foods, ADAM, Superior Men's Multi, 90 Softgels | | |
Combats spring depression Most Useful Review 4 people found this helpful It effectively combats spring depression. I purchased it for a 60-year-old man with diabetes. After just a week of use, there was already a noticeable improvement; he found it easy to get up in the mornings and didn't feel the urge to sleep by 6 p.m. I was very pleased with the results. Stabilises mood Most Useful Review Multivit has a stabilising effect on insomnia, depression, autonomic disorders, and other conditions, such as during menopause or old age. The quality ingredients are natural, relieving excess stress, stimulating brain function, improving concentration, increasing performance, and normalising sleep and mood. The capsules are of medium size. GABA, a neurotransmitter of the central nervous system, enhances sleep quality, with the greatest amount of growth hormone being released at night. This component lessens the effects of stress factors, allowing for deeper and more effective sleep. The dosage is ideal. |
 Solgar, Skin, Nails & Hair, Advanced MSM Formula, 60 Tablets | | |
Improved mental health Most Useful Review Excellent quality, an ingredient that supports the health of both hair and mind. It has numerous benefits contributing to the wellness of hair and nails. I have used it for several years, and it effectively preserves strong, healthy hair while aiding in my battle against depression. Strengthened hair Most Useful Review With the onset of autumn, I frequently encounter the issue of dry skin and, regrettably, frazzled hair. This time, I also endured significant stress and depression, which certainly did not improve my gloomy state. I noticed an alarming amount of hair on my comb, enough to almost craft a wig. I purchased this complex from Solgar, which includes vitamin D and omega 3, and addressed my concerns. I felt the effects almost instantly; my hair seems stronger. I shall continue to monitor the condition of both my hair and skin. |
 21st Century, Extra Strength, Quick Dissolve Melatonin, Cherry, 10 mg, 360 Tablets | | |
Eliminated bad moods Most Useful Review 91 people found this helpful This is the best vitamin I’ve ever tried. It has helped me overcome my bad moods and manage my depression. I will never switch to any other vitamin again. Effective for sleep Most Useful Review My son, who has Asperger’s and depression, has been taking a 5mg dose of Melatonin for years. We recently tried a stronger dosage I found on Iherb. He takes it just after dinner, and it ensures he sleeps through the night, which makes him very happy. |
 Natrol, Melatonin Gummies, Strawberry, 10 mg, 90 Gummies (5 mg per Gummy) | | |
Sleep quality improved Most Useful Review I've suffered from insomnia, anxiety, and depression for over 14 years, having never enjoyed a good night's sleep until I tried these gummies. Their quality is amazing and completely natural! Initially, I thought I would need the 10mg dosage due to using over-the-counter sleep aids, but I've found that I only need to take one gummy. Now, I enjoy the best sleep without waking up groggy, and my sleep rating on my Fitbit is at 90%. I love that the ingredients are all natural, and the price is fantastic. I will be a forever user of these gummies, which have been a lifesaver for both myself and my daughter. Helps with sleep Most Useful Review My partner and I have been taking these for over a year now, and we absolutely love them. Both of us suffer from mental health issues that hinder our ability to sleep, including anxiety, depression, and ADHD. These gummies are the only product that helps us get to sleep. This is truly an amazing product, and I am a repeat buyer. |
 Natrol, Melatonin, 5 mg, 60 Tablets | | |
Menopause relief Most Useful Review 2 people found this helpful Melatonin saved me from insomnia caused by menopause. Despite being terrified of potential side effects, I tried it and found it effective. One hour before sleep, I feel drowsy and able to fall asleep easily after struggling for ages. Initially, I used it every two days, but after a month, I could sleep without it. It feels like a memory inside my body. Trauma recovery Most Useful Review Following a severe trauma, I struggled with sleep and depression. These melatonin tablets help me relax and fall asleep within half an hour. I highly recommend this product as it has been invaluable in restoring my ability to sleep. |
 Mason Natural, Vitamin B-1, 250 mg, 100 Tablets | | |
Quick effect observed Most Useful Review 18 people found this helpful Great remedy for a poor mood. An excellent solution for various psychological issues, including depression, nightmares, irritability, and nervousness. It acts swiftly, usually within 15-20 minutes. I often take it alongside a complex of vitamins and minerals. I highly recommend it as a beneficial and safe treatment for depression and psychological concerns. No psychiatrist or psychologist will advise you because you won't need to see them anymore. Helpful for neuroses Most Useful Review Thank you very much for vitamin B1; it tremendously helps with neuroses and depression. |
 Solgar, Vitamin B1, 500 mg, 100 Tablets | | |
Effective for anxiety Most Useful Review 3 people found this helpful Thiamine — or vitamin B1 — is surprisingly effective for anxiety and depression. Often called the “anti-stress” vitamin, low blood thiamine levels are linked with generalized anxiety disorder. I take one tablet daily with no adverse side effects. Quick relief Most Useful Review 15 people found this helpful Great dosage, very large. I took it to overcome spring depression and weakness. It helped very quickly. However, it is not advisable to consume such doses consistently. It's beneficial for recovery post-illness, especially for the elderly. |
 Solgar, Vitamin B1, 100 mg, 100 Vegetable Capsules | | |
Fatigue relief Most Useful Review 7 people found this helpful Excellent! Over the past six months, I struggled with constant fatigue; getting out of bed felt impossible! I suffered from headaches and relentless depression. On my doctor’s advice, I began taking B vitamins, specifically B1 and B6, along with magnesium and D3. I chose the Solgar brand because I trust its quality. Stress management Most Useful Review B1 is an essential vitamin that comes in quality packaging for convenience. It significantly impacts nervous system function and helps manage stress and depression. Niacin is key for good nerve function and mental health. This vitamin also helps regulate minerals in the body, supporting health and improving wellbeing. Its use benefits both physical and mental health, aiding coping with stress and ensuring normal nervous system function. |
 Doctor's Best, Alpha-Lipoic Acid 600, 600 mg, 180 Veggie Caps | | |
Spring depression improved Most Useful Review 6 people found this helpful Indispensable product! Spring depression was not an issue for me any longer, thanks to this. Depression alleviated Most Useful Review This product significantly improves my depression when I take it. |
 NOW Foods, Double Strength Taurine, 1,000 mg, 250 Veg Capsules | | |
Better sleep Most Useful Review I'm very pleased, improving my nervous system condition. I’ve taken this for over a month and my sleep quality has improved significantly, my mood is better, and fatigue has decreased. I strongly recommend it to anyone experiencing depression during these tough times. The service and delivery were also excellent. Boosts energy Most Useful Review Taurine has greatly improved heart function and energy levels while combating depression. This form of taurine is excellent for overall wellbeing. |
 Solgar, L-Lysine, Free Form, 500 mg, 250 Vegetable Capsules | | |
Mood improvement Most Useful Review 1 people found this helpful Lysine is an essential amino acid that must be obtained from food or supplements. It aids athletes in muscle recovery, supports skin and hair health, and helps those prone to depression. It also assists the elderly in preventing osteoporosis and those suffering from herpes in mitigating symptoms. Cold sore assistance Most Useful Review Lysine improves calcium absorption, restoring the body's normal state. It effectively relieves anxiety syndrome and alleviates depression harmlessly. Additionally, it is helpful for cold sores. |
 ChildLife Essentials, Essentials, Echinacea, Natural Orange, 1 fl oz (30 ml) | | |
Essential for children Most Useful Review Echinacea is a vital addition to any medicine cabinet, especially for children. Its natural ingredients and sweet orange flavour appeal to kids while effectively strengthening their immune systems. This gentle stimulant is essential during cold seasons and helps them recover more swiftly from illnesses, including cases of depression. Immunity booster Most Useful Review 4 people found this helpful Echinacea is a potent natural immunity booster and is effective in treating and preventing respiratory diseases and depression. It aids in alleviating fatigue and supports the body during recovery periods, while also being beneficial in complex therapies for various ailments, including skin pathologies. Echinacea is especially useful for children to strengthen their immune systems, particularly those attending school. |
 NOW Foods, Acetyl-L-Carnitine, 500 mg, 200 Veg Capsules | | |
Mind clarity boost Most Useful Review 24 people found this helpful Great product! I take it thrice daily, and it sharpens my mind, improves memory, and I opted for this natural solution rather than becoming reliant on pills for depression. It truly works! Menopause relief Most Useful Review 12 people found this helpful After about two weeks of taking Acetyl L-Carnitine, my depression, anxiety, and irritability linked to menopause disappeared, allowing me to spend my days calmly as if clouds had cleared. |
 NOW Foods, Sunflower Lecithin, 1,200 mg, 200 Softgels | | |
Quick relief from depression Most Useful Review 116 people found this helpful It removes depression and nervousness in no time. Improvements noticed quickly Most Useful Review 101 people found this helpful After using this supplement for a few months, I observed immediate changes in my mental health. It has truly assisted me in overcoming a lingering depression I have experienced for quite some time. |
 Doctor's Best, Glucosamine Chondroitin MSM with OptiMSM®, 240 Capsules | | |
Renewed strength Most Useful Review 1 people found this helpful The quality is excellent. There was a time when I felt dreadful, with pain in my spine and joints, high blood pressure, and persistent insomnia. My legs felt as though they were weighed down with ten-kilogram weights, and I often awoke at night due to muscle cramps. This led to a constant state of exhaustion and the question of my purpose in life. Depression began to set in. After starting on glucosamine, I noticed a surge of energy after two weeks and began to make plans once again, signalling that life was returning to normal. Relief from symptoms Most Useful Review Excellent! Omega 3 is a crucial component of brain nerve cells and possesses anti-inflammatory properties. Research indicates that conditions such as depression, anxiety, and degenerative disorders are linked to brain inflammation. Omega 3 may alleviate these symptoms effectively. |
 Nature's Bounty, Evening Primrose Oil, 1,000 mg, 60 Rapid Release Softgels | | |
Improved wellbeing Most Useful Review 1 people found this helpful Good quality and composition, effectively helps with PMS, depression, and irritability while supporting female metabolism. After taking it, both my skin and overall wellbeing improved. The capsules are large but easy to swallow, with a neutral taste. Reduced symptoms Most Useful Review According to recent research, EPO can alleviate some symptoms of premenstrual syndrome, such as depression, irritability, and abdominal discomfort. Scientists suggest that these symptoms in some women are linked to high sensitivity to prolactin. GLA, upon ingestion, converts to prostaglandin E1, which mitigates the body's response to prolactin, thus relieving PMS symptoms. I found it beneficial; my long-term migraines and irritations subsided, and my libido increased. I only take it once a day in the evening. A good product. |
 Jarrow Formulas, Vegan Saccharomyces Boulardii + MOS, 5 Billion CFU, 180 Veggie Capsules | | |
Improved mood Most Useful Review 7 people found this helpful Great non-GMO, vegan product that I use to combat mould toxicity. I got this product on a recommendation for mould exposure. I particularly like that it's non-GMO and vegan. So far, I've noticed improvement in my depression, which is a symptom of mould exposure. My stomach also feels better. It’s early days, as I’ve only been taking it for a few weeks, but I believe it’s working for me. Helps depression Most Useful Review 1 people found this helpful Cool product. It helps with depression. |
 NOW Foods, Potassium Plus Iodine, 180 Tablets | | |
Mood improvement Most Useful Review 9 people found this helpful After regularly taking iodine, I felt revitalised. No more drowsiness and my mood swung positively, even my memory improved. I neglected vitamins post-childbirth, leading to dental and hair issues, alongside postpartum depression. Now, I consistently take my vitamins and, since they lack iodine, I make sure to supplement with Potassium + iodine. Result: excellent condition and improved mood. Depression ceased Most Useful Review I have grade 2 diffuse goitre and started taking this on a doctor's recommendation, combined with selenium. It significantly improved my mood and eliminated drowsiness and depression. After 6 months, my ultrasound scan showed improvement. |
 Jarrow Formulas, Evening Primrose, 1,300 mg, 60 Softgels | | |
Reduced PMS symptoms Most Useful Review 2 people found this helpful I’m feeling good! It’s been three weeks since I started taking it, and I’ve noticed a clear reduction in my premenstrual PMS symptoms, including depression and irritability. This improvement may also be due to other supplements I’ve begun using, but my atopic dermatitis inflammation has calmed, my skin appears healthier, and I’ve seen many other benefits. I will definitely purchase this again! Enhanced mood stability Most Useful Review 2 people found this helpful Primrose stabilises insomnia, depression, autonomic disorders, and other conditions like menopause or old age, featuring high-quality natural ingredients. It alleviates excess stress, stimulates brain function, improves concentration, and normalises sleep and mood. The medium-sized capsules contain GABA, a neurotransmitter that enhances sleep quality, especially when growth hormone is predominantly released at night, limiting stress effects for deeper, more effective rest. The dosage is optimal. |
 NOW Foods, Mega D-3 & MK-7, 5,000 IU / 180 mcg, 60 Capsules | | |
Relieved depression symptoms Most Useful Review 12 people found this helpful This vitamin really helped my mother out of a severe depression as she was deficient in vitamin D. I ordered three packs at a discount and plan to order more. It's fantastic that it includes vitamin K, making it safe for older individuals to take. The dosage is great, and she felt better quickly. Improved depression significantly Most Useful Review 5 people found this helpful This supplement has a high dosage of vitamin D and includes vitamin K, which can be lacking due to its antagonistic effect. I initially took it for panic disorder and to combat winter depression. It has significantly improved my hay fever symptoms, and I hope my spring allergies will ease too. My winter depression has also lessened thanks to this. |
 NOW Foods, Super Primrose, 1,300 mg, 120 Softgels | | |
Natural remedy Most Useful Review 2 people found this helpful Miracle oil! These capsules are a natural solution for many 'female' issues. They help normalise hormones and alleviate premenstrual syndrome, including abdominal pain and depression. They also enhance skin elasticity and support the immune system. I recommend these capsules to all women! Hormonal balance Most Useful Review 2 people found this helpful A wonderful natural remedy for various 'female' concerns! Evening primrose oil helps stabilise hormones and alleviates PMS symptoms like abdominal pain and depression. It also enhances skin elasticity and supports the immune response. I highly recommend these capsules! |
 NOW Foods, Vitamin K-2, 100 mcg, 100 Veg Capsules | | |
Mood transformation Most Useful Review 1 people found this helpful The best K2 I take with D3; my mood improved, and my apathy and depression vanished! I drink it as my dentist recommended, while also adding calcium, phosphorus, and magnesium, which reduced my back pain. I've frequently visited the dentist due to ongoing caries, which my new doctor attributes to vitamin deficiencies. This excellent site offers fantastic vitamins! Improved mood Most Useful Review 15 people found this helpful Excellent! These vegetarian capsules are great. The quantity is substantial and reasonably priced for a second brand. I appreciate that the capsules are vegetarian, eliminating concern about gelatin. They have a slightly off-putting smell, but after a month of use, I noticed improvements. Vitamin D aids in absorption, which helped alleviate my depression and enhance my mood. Praise be to God. If you find my comment helpful, please remember to like it. |
 NOW Foods, Ubiquinol, 100 mg, 120 Softgels | | |
Supports heart health Most Useful Review 16 people found this helpful Excellent antioxidant, improves heart and nervous system function. Ubiquinol, an enhanced form of coenzyme Q10, supports the cardiovascular system, acts as an antioxidant, and boosts the immune system. It's beneficial for the nervous system, heart, and brain, and helps prevent depression while increasing resistance to stress. The capsules are small. I sincerely recommend it. Mood improvement Most Useful Review 2 people found this helpful This drug is my salvation as it prevents depression and improves my mood. Mitochondria, which suffer from stress, benefit greatly from it. The capsules are small and have a neutral taste. |
 Gaia Herbs, Rhodiola Rosea, 120 mg, 60 Vegan Liquid Phyto-Caps | | |
Felt relief quickly Most Useful Review 33 people found this helpful Works wonders for depression and anxiety. Having endured depression and anxiety throughout much of my adult life, I began taking Gaia Rhodiola Rosea alongside Theanine. Now, I feel virtually free from both conditions! It took a week or two to experience full alleviation of symptoms after experimenting with the dosage. I take one Rhodiola Rosea capsule in the morning and another in the afternoon on an empty stomach, plus 100 mg of L-theanine. While these supplements made a significant difference, I also engage in activities like yoga, exercise, laughter, and spiritual pursuits to enhance my happiness. Motivated and energetic Most Useful Review 14 people found this helpful A game changer for me. Within days of starting Rhodiola Rosea, my outlook and mood significantly improved. I felt uplifted and energised, leading me to be more motivated and proactive in addressing personal issues. I now rise earlier and engage in life more fully. This allowed me to stop taking Zoloft, which I had used for years, and I feel lighter and more flexible. I now take Rhodiola every other day, and it continues to work effectively for me. It's an affordable herb with remarkable healing properties, and I even recommended it to a friend facing severe depression. |
 NOW Foods, L-Carnitine, 1,000 mg, 50 Tablets | | |
Improves clarity Most Useful Review 4 people found this helpful I find great value in this higher dose. It has significantly enhanced my mental clarity and helped manage my depression and brain fog. Supports mood health Most Useful Review This supplement has positively impacted my mood and reduced the risk of depression, proving beneficial for those with mood disorders. |
 Jarrow Formulas, Lactoferrin, Freeze Dried, 250 mg, 60 Capsules | | |
Boosted immunity noted Most Useful Review 1 people found this helpful It increases immunity and aids iron absorption. I take it alongside iron supplementation, and my ferritin levels have already risen. My health has improved notably: my depression has lessened, sleeps better now, and my brain feels active again! Additionally, I've noticed an enhancement in my immunity! Improved sleep quality Most Useful Review 38 people found this helpful This supplement appears to help with overall well-being. Taking one to three tablets before bed seems to have improved various aspects of my health, including sleep, rhinitis, acne, bowel movement, and depression, all without side effects. I believe it offers the best balance of benefits and risks. |
 NOW Foods, Certified Organic Spirulina, Double Strength, 1,000 mg, 120 Tablets | | |
Alleviated spring depression Most Useful Review 1 people found this helpful I was pleasantly surprised by the effectiveness! After taking spirulina with Vitamin D, I felt lighter, my skin improved, and I experienced a superb mood, without the dreadful spring depression caused by vitamin deficiency. While others were sluggish at work, I felt cheerful. I will continue taking spirulina regularly! Disappeared depression Most Useful Review An amazing product! I initially bought it for my father, who has type 2 diabetes. By the third day, I noticed improvements with his strength and mood, almost as if depression vanished. After a week, he no longer needed blood pressure medication, and his sugar levels normalised. I regretted trying another brand, as it couldn’t compare to this product’s effects. |
 NOW Foods, Essential Oils, Peppermint, 4 fl oz (118 ml) | | |
Relaxes depression Most Useful Review 1 people found this helpful Excellent! The scent of refreshing drowsiness relieves my depression and makes me noticeably relaxed. Soothes depression Most Useful Review 1 people found this helpful Very good! This peppermint essential oil with lemon essential oil has a fresh aroma and feels wonderful to use, alleviating my depression and improving my mood. Natural ingredients are always preferable to medicines, catering better to the needs of both body and mind for users of any age. |
 NOW Foods, St. John's Wort, 300 mg, 100 Veg Capsules | | |
No more anxiety Most Useful Review 83 people found this helpful No More Depression or Anxiety attacks! My family has a strong history of depression, and I began to notice signs in myself around age 35. My doctor prescribed various medications, but they didn’t work well and caused severe anxiety attacks. After reading about St. John’s Wort's success in Europe, I decided to try it. I stopped all prescriptions and have been using St. John’s Wort for 15 years now. I am free from depression and anxiety attacks, feeling quite mellow instead. I take 2 in the morning and 1 at noon. I’m very pleased with the quality and price of the Now Foods brand. Calmer and brighter Most Useful Review 71 people found this helpful I did not expect such an effective result. I feel calmer, and my sleep has improved significantly. The depression has largely disappeared. After two weeks, I forgot to take it regularly, as I had developed interests and energy I had lacked before. Now, I only take it occasionally when my nerves act up. |
 Nature's Bounty, St. John's Wort, 300 mg, 100 Capsules | | |
Supports recovery Most Useful Review This made a significant difference to my ADD husband. He felt much calmer and more controlled, and I noticed an improvement in his irrational behaviour and depression. It supported his recovery from drug dependence and is a great alternative to prescription antidepressants. Mood balance achieved Most Useful Review 7 people found this helpful Works for me! I suffered from mild depression symptoms. I started taking this and after about 5 to 6 weeks, I could feel the effects beginning to take hold. It is subtle, but I notice the difference as my mood is now balanced, and I haven't felt depressed for a long time. I am currently on my fourth bottle, taking 3 pills a day. |
 NOW Foods, Potassium Citrate, 99 mg, 180 Veg Capsules | | |
Muscle pain relief Most Useful Review I found relief from muscle pain, fatigue, and depression after trying potassium. It helps maintain heart health, reduces the risk of stroke, and supports bones and muscles, amongst other benefits. Postpartum relief Most Useful Review 44 people found this helpful I recommend all mothers to use this after giving birth. The girls of Chavani often struggle with postpartum depression, and this helps restore their short-term memory, which can be lost due to depression. I advise combining copper, sodium, 10,000 IU vitamin D by Solgar, a vitamin B complex, magnesium, and Omega-rich supplements to alleviate anxiety and depression. |
 Kyolic, Aged Garlic Extract™, Cardiovascular Health, Original Formula 100, 600 mg, 300 Capsules (300 mg Per Capsule) | | |
Boosted serotonin production Most Useful Review 54 people found this helpful Garlic extract possesses anti-inflammatory and bactericidal properties. The supplement bolsters the immune system and helps to normalise metabolism. Positive effects include improved blood oxygen saturation and detoxification of harmful substances. Moreover, it safeguards the liver from chemicals and medications, boosts antibody production to combat viruses, restores intestinal microflora, and enhances men's potency. It also combats fungi, aids insulin production in diabetes, clears respiratory sputum, prevents heart and vascular diseases, regulates lipid balance, and aids weight management. Notably, it promotes serotonin production, enabling one to better cope with depression. I found it beneficial. Effective stress relief Most Useful Review Garlic effectively reduces stress and anxiety while aiding in coping with depression. It promotes serotonin production as well. I was recommended garlic extract for detox, and one jar was sufficient for three courses! I'm a loyal customer of this brand, which offers a variety tailored to one's needs. |
 Life Extension, DHEA, 25 mg, 100 Capsules | | |
Reduces depression Most Useful Review 1 people found this helpful Needed for those who lack adrenal hormone to maintain hormonal balance. There is a noticeable effect, as it reduces depression and also improves hair quality. I highly recommend it! Improves concentration Most Useful Review It has helped me cope with depression and has greatly improved my concentration. I struggled with numerous intrusive thoughts, but now my condition has significantly improved. |
 Citrucel, Methylcellulose Fiber Therapy for Irregularity, 180 Fiber Caplets | | |
Calming effects Most Useful Review 257 people found this helpful I bought this for a girl who was experiencing a mild autumn depression. After a few days of use, she found that she was coping better with stress and felt much calmer overall. Her muscles relaxed, and her immune system seemed to be recovering. Importantly, she did not experience any side effects. Mood improvement Most Useful Review 211 people found this helpful I have tried numerous omega brands and this one is by far my favourite. If you take 2 capsules daily, it lasts two months, which is quite economical. I experience a light citrus burp instead of fishy, which is a plus. It has improved my hair and nails and helped my post-Covid depression significantly. The packaging is excellent and the capsules, though large and straw-yellow, are easy to swallow. Drinking omega is advisable for everyone, as it truly enhances health and mood. |
 NOW Foods, Ginkgo Biloba, Double Strength, 120 mg, 200 Veg Capsules | | |
Relieved panic attacks Most Useful Review 9 people found this helpful I ordered this six months ago and take one capsule each morning. As someone who suffers from depression, I noticed my state stabilised, and panic attacks diminished after about a month and a half. I'm very satisfied and will order again. Thank you! Reduced depressive symptoms Most Useful Review 1 people found this helpful Ginkgo Biloba is a powerful antioxidant that enhances memory, concentration, and stabilises cardiovascular health. It improves blood circulation, reduces the risk of blood clots and heart issues, and helps alleviate symptoms of depression. |
 Doctor's Best, Extra Strength Ginkgo, 120 mg, 360 Veggie Caps | | |
Panic reduction Most Useful Review 117 people found this helpful Alongside "Gotu Kola," I've seen remarkable effects! My weight issues and memory lapses have resolved. My brother, who had severe anxiety and depression, experienced a remarkable recovery over two months, resulting in a stable state for six months after stopping medication. These supplements are truly miraculous! Supports mental health Most Useful Review 26 people found this helpful Vitamin For The Brain: Aging processes are irreversible, and in large cities, under conditions of unfavourable ecology, chronic stress, and fatigue, the first age-related symptoms appear at a young age. Ginkgo extract helps stimulate blood vessel expansion, reduce pressure and strokes, lower cholesterol levels, and improve brain health, aiding in symptoms of depression and enhancing overall cognitive function. |
 NOW Foods, Resveratrol, 200 mg, 120 Veg Capsules | | |
Improves brain activity Most Useful Review 8 people found this helpful I purchased this for my sister following her illness. Since using it, she has felt a surge of energy and cheerfulness. Resveratrol slows cellular aging, protects against depression, enhances cerebral blood flow, and improves memory. Helps brain injury Most Useful Review I appreciate that this brand crosses the blood-brain barrier. Resveratrol benefits my brain injury, anxiety, depression, and energy levels significantly. |
 NOW Foods, L-Carnosine, 500 mg, 100 Veg Capsules | | |
Depression relief Most Useful Review 4 people found this helpful It works for depression! My depression has significantly reduced since I started taking it. The synergistic effect of combining it with supplements like B vitamins, vitamin C, vitamin E, and niacin has proven beneficial. Mental enhancement Most Useful Review 3 people found this helpful I find L-Carnosine to be an excellent dietary supplement and a powerful antioxidant, especially for those over 40. It lowers blood sugar, blood pressure, and enhances cardiovascular health. Furthermore, it boosts brain function and helps those experiencing chronic fatigue and depression. The product’s quality, packaging, and prompt delivery are commendable. |
 Solgar, Evening Primrose Oil, 1,300 mg, 60 Softgels | | |
Eliminated PMS symptoms Most Useful Review The add-on worked exceptionally well. My wife used it for two months, alleviating her PMS symptoms: depression, irritability, and abdominal pain. The quality is excellent, with a neutral taste and glass jar packaging. Although the tablets are large, they are easy to swallow. I highly recommend it! Reduced PMS symptoms Most Useful Review I struggled with severe PMS symptoms but wished to avoid hormonal contraceptives. After taking two pills a day, I transitioned from suffering two weeks of debilitating cramps to only a couple of days with manageable discomfort. Additionally, irritability, depression, anxiety, and lower back pain linked to my period were significantly alleviated. Highly recommend! |