Last update
3/25/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.4
USERS' SCORE
Moderately Good
Based on 20 Reviews
7.8
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
L-Theanine
200 mg
*
Inositol
100 mg
*
Top Medical Research Studies
8
L-theanine shows potential antidepressant effects
We examined how L-theanine, a compound found in green tea, influences depressive behaviors in a rat model. Using specific behavioral tests, such as the open-field and forced swim tests, we observed that L-theanine improved depressive-like behaviors.
Our findings indicated that it boosted levels of key neurotransmitters—serotonin, norepinephrine, and dopamine—in certain brain regions. This suggests that L-theanine could have potential antidepressant effects, possibly by interacting with these neurotransmitters in brain areas associated with mood regulation.
Our findings indicated that it boosted levels of key neurotransmitters—serotonin, norepinephrine, and dopamine—in certain brain regions. This suggests that L-theanine could have potential antidepressant effects, possibly by interacting with these neurotransmitters in brain areas associated with mood regulation.
Read More
8
We explored the effects of l-theanine, a natural amino acid found in green tea, on patients diagnosed with major depressive disorder (MDD) in an 8-week open-label study. We involved 20 participants who took 250 mg of l-theanine daily in addition to their regular medication.
Our findings indicated a significant reduction in depression and anxiety symptoms, as well as improved sleep quality and cognitive functions. However, it's important to note that because this study wasn't placebo-controlled, further research is needed to confirm these promising effects.
Our findings indicated a significant reduction in depression and anxiety symptoms, as well as improved sleep quality and cognitive functions. However, it's important to note that because this study wasn't placebo-controlled, further research is needed to confirm these promising effects.
Read More
8
We investigated the effects of l-theanine added to sertraline in treating major depressive disorder (MDD). In a six-week, double-blind trial, participants took either l-theanine or a placebo alongside their medication. Results showed that those receiving l-theanine experienced a greater reduction in depression symptoms and higher remission rates compared to the placebo group. Though the study had a small sample size, the findings suggest l-theanine may be a promising adjunct therapy for improving treatment outcomes in MDD. More extensive research is needed for confirmation.
Read More
Most Useful Reviews
9
Fostered calmness
14 people found this helpful
During a challenging period of betrayal, this supplement provided much-needed support. After taking it, I felt noticeable calmness, bordering on euphoria, without the side effects of sleepiness. I felt like I was in a meditative state.
Read More
9
Quick mood lift
3 people found this helpful
This product effectively alleviates depression, working within minutes. I initially took four capsules a day but now only use one daily. It elevates my mood and provides energy, and I’ve trusted it for over four years.
Read More
7.5
Consistent calmness
2 people found this helpful
After three weeks of L-Theanine, I noticed a marked improvement in my mood disorder. I no longer experience emotional swings or daily anxiety, helping me feel more relaxed and capable.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.4
- All Researches
8
We investigated the effects of l-theanine added to sertraline in treating major depressive disorder (MDD). In a six-week, double-blind trial, participants took either l-theanine or a placebo alongside their medication. Results showed that those receiving l-theanine experienced a greater reduction in depression symptoms and higher remission rates compared to the placebo group. Though the study had a small sample size, the findings suggest l-theanine may be a promising adjunct therapy for improving treatment outcomes in MDD. More extensive research is needed for confirmation.
Read More
8
L-theanine shows potential antidepressant effects
We examined how L-theanine, a compound found in green tea, influences depressive behaviors in a rat model. Using specific behavioral tests, such as the open-field and forced swim tests, we observed that L-theanine improved depressive-like behaviors.
Our findings indicated that it boosted levels of key neurotransmitters—serotonin, norepinephrine, and dopamine—in certain brain regions. This suggests that L-theanine could have potential antidepressant effects, possibly by interacting with these neurotransmitters in brain areas associated with mood regulation.
Our findings indicated that it boosted levels of key neurotransmitters—serotonin, norepinephrine, and dopamine—in certain brain regions. This suggests that L-theanine could have potential antidepressant effects, possibly by interacting with these neurotransmitters in brain areas associated with mood regulation.
Read More
8
We explored the effects of l-theanine, a natural amino acid found in green tea, on patients diagnosed with major depressive disorder (MDD) in an 8-week open-label study. We involved 20 participants who took 250 mg of l-theanine daily in addition to their regular medication.
Our findings indicated a significant reduction in depression and anxiety symptoms, as well as improved sleep quality and cognitive functions. However, it's important to note that because this study wasn't placebo-controlled, further research is needed to confirm these promising effects.
Our findings indicated a significant reduction in depression and anxiety symptoms, as well as improved sleep quality and cognitive functions. However, it's important to note that because this study wasn't placebo-controlled, further research is needed to confirm these promising effects.
Read More
8
Inositol's role in depression unclear
We explored the role of inositol in alleviating depression among children and adolescents. This systematic review gathered data from nine studies involving 561 participants, focusing on the effectiveness of omega-3 fatty acids alongside inositol in combating depressive symptoms.
Our analysis found that while inositol is often included with omega-3 in combination therapies, its isolated effect on depression could not be clearly established. The results indicated that when omega-3 is combined with inositol, it showed promising efficacy, acting as a potential support for traditional therapies.
However, we noted that there was no significant improvement in depression symptoms compared to placebo treatments when evaluating these interventions individually. Ultimately, omega-3 paired with psychoeducational psychotherapy emerged as the most effective approach, but the impact of inositol on its own remains inconclusive.
These findings suggest a need for future studies to assess inositol individually, helping us better understand its potential in managing depression.
Our analysis found that while inositol is often included with omega-3 in combination therapies, its isolated effect on depression could not be clearly established. The results indicated that when omega-3 is combined with inositol, it showed promising efficacy, acting as a potential support for traditional therapies.
However, we noted that there was no significant improvement in depression symptoms compared to placebo treatments when evaluating these interventions individually. Ultimately, omega-3 paired with psychoeducational psychotherapy emerged as the most effective approach, but the impact of inositol on its own remains inconclusive.
These findings suggest a need for future studies to assess inositol individually, helping us better understand its potential in managing depression.
Read More
8
We conducted a detailed analysis of the effects of myo-inositol, alongside cocoa polyphenols and soy isoflavones, on managing symptoms of depression in menopausal women with metabolic syndrome.
In this study, 200 participants were observed over a six-month period while taking a daily supplement. At the beginning, many reported moderate depression symptoms. After six months, we noted a significant reduction, with only 56% of women reporting similar symptoms compared to 87% at the start.
This improvement in mood is quite promising and suggests that myo-inositol can play a key role in alleviating depressive symptoms during menopause. While the study focused on a specific group of women, the results indicate a potential for using natural compounds to ease their struggles.
In this study, 200 participants were observed over a six-month period while taking a daily supplement. At the beginning, many reported moderate depression symptoms. After six months, we noted a significant reduction, with only 56% of women reporting similar symptoms compared to 87% at the start.
This improvement in mood is quite promising and suggests that myo-inositol can play a key role in alleviating depressive symptoms during menopause. While the study focused on a specific group of women, the results indicate a potential for using natural compounds to ease their struggles.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 20 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Fostered calmness
14 people found this helpful
During a challenging period of betrayal, this supplement provided much-needed support. After taking it, I felt noticeable calmness, bordering on euphoria, without the side effects of sleepiness. I felt like I was in a meditative state.
Read More
9
Quick mood lift
3 people found this helpful
This product effectively alleviates depression, working within minutes. I initially took four capsules a day but now only use one daily. It elevates my mood and provides energy, and I’ve trusted it for over four years.
Read More
7.5
Consistent calmness
2 people found this helpful
After three weeks of L-Theanine, I noticed a marked improvement in my mood disorder. I no longer experience emotional swings or daily anxiety, helping me feel more relaxed and capable.
Read More
9
Enhances sleep quality
1 people found this helpful
After trying GABA and L-Theanine, I noticed a significant improvement in my sleep quality and reduced stress. This combination alleviated my depression and has left me feeling refreshed each day.
Read More
9
Life saver
1 people found this helpful
I've been using this for five years, and it has been crucial in managing my depression and anxiety. Whenever I feel down, I rely on it. It truly is a life saver!
Read More
Frequently Asked Questions
9
Quick mood lift
3 people found this helpful
This product effectively alleviates depression, working within minutes. I initially took four capsules a day but now only use one daily. It elevates my mood and provides energy, and I’ve trusted it for over four years.
7.5
Consistent calmness
2 people found this helpful
After three weeks of L-Theanine, I noticed a marked improvement in my mood disorder. I no longer experience emotional swings or daily anxiety, helping me feel more relaxed and capable.
7.5
Improved emotional state
264 people found this helpful
I have suffered from emotional discomfort and depression for a long time, worsened by the pandemic. After a month of taking these capsules, I feel calmer at work, my family relationships have improved, and I no longer feel apathetic. If this resonates with you, consider ordering these pills; it might be time for a change.
9
Fostered calmness
14 people found this helpful
During a challenging period of betrayal, this supplement provided much-needed support. After taking it, I felt noticeable calmness, bordering on euphoria, without the side effects of sleepiness. I felt like I was in a meditative state.
9
Enhances sleep quality
1 people found this helpful
After trying GABA and L-Theanine, I noticed a significant improvement in my sleep quality and reduced stress. This combination alleviated my depression and has left me feeling refreshed each day.
7.5
Alleviates irritability
1 people found this helpful
With the combination of this product and GABA, I've noticed better sleep and a reduction in waking during the night. It has helped me feel calmer, reducing my irritability and depression.
8
We investigated the effects of l-theanine added to sertraline in treating major depressive disorder (MDD). In a six-week, double-blind trial, participants took either l-theanine or a placebo alongside their medication. Results showed that those receiving l-theanine experienced a greater reduction in depression symptoms and higher remission rates compared to the placebo group. Though the study had a small sample size, the findings suggest l-theanine may be a promising adjunct therapy for improving treatment outcomes in MDD. More extensive research is needed for confirmation.
7
This study focused on how L-theanine, administered over four weeks, affects stress-related symptoms and cognitive functions in healthy adults.
We found that participants who took 200 mg of L-theanine daily reported decreased depression, anxiety, and improved sleep quality compared to those on a placebo. Measures like verbal fluency and executive function showed significant improvements as well.
Our results suggest that L-theanine could be a helpful option for those facing stress and cognitive challenges, promoting better mental well-being.
We found that participants who took 200 mg of L-theanine daily reported decreased depression, anxiety, and improved sleep quality compared to those on a placebo. Measures like verbal fluency and executive function showed significant improvements as well.
Our results suggest that L-theanine could be a helpful option for those facing stress and cognitive challenges, promoting better mental well-being.
8
We explored the effects of l-theanine, a natural amino acid found in green tea, on patients diagnosed with major depressive disorder (MDD) in an 8-week open-label study. We involved 20 participants who took 250 mg of l-theanine daily in addition to their regular medication.
Our findings indicated a significant reduction in depression and anxiety symptoms, as well as improved sleep quality and cognitive functions. However, it's important to note that because this study wasn't placebo-controlled, further research is needed to confirm these promising effects.
Our findings indicated a significant reduction in depression and anxiety symptoms, as well as improved sleep quality and cognitive functions. However, it's important to note that because this study wasn't placebo-controlled, further research is needed to confirm these promising effects.
References
- Shamabadi A, Kafi F, Arab Bafrani M, Asadigandomani H, A Basti F, et al. l-theanine adjunct to sertraline for major depressive disorder: A randomized, double-blind, placebo-controlled clinical trial. J Affect Disord. 2023;333:38. 10.1016/j.jad.2023.04.029
- Hidese S, Ogawa S, Ota M, Ishida I, Yasukawa Z, et al. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients. 2019;11. 10.3390/nu11102362
- Shen M, Yang Y, Wu Y, Zhang B, Wu H, et al. L-theanine ameliorate depressive-like behavior in a chronic unpredictable mild stress rat model via modulating the monoamine levels in limbic-cortical-striatal-pallidal-thalamic-circuit related brain regions. Phytother Res. 2019;33:412. 10.1002/ptr.6237
- Hidese S, Ota M, Wakabayashi C, Noda T, Ozawa H, et al. Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study. Acta Neuropsychiatr. 2017;29:72. 10.1017/neu.2016.33
- Lam C, Han L, McIntyre RS, Teopiz KM, Cao B. Comparative Efficacy of Omega-3 Fatty Acid with Other Interventions for Depression in Children and Adolescents: A Systematic Review and Network Meta-Analysis. J Child Adolesc Psychopharmacol. 2024;34:282. 10.1089/cap.2024.0017
- Mainini G, Ercolano S, De Simone R, Iavarone I, Lizza R, et al. Dietary Supplementation of Myo-Inositol, Cocoa Polyphenols, and Soy Isoflavones Improves Vasomotor Symptoms and Metabolic Profile in Menopausal Women with Metabolic Syndrome: A Retrospective Clinical Study. Medicina (Kaunas). 2024;60. 10.3390/medicina60040598
- El-Heis S, Barton SJ, Chang HF, Nield H, Cox V, et al. Maternal mood, anxiety and mental health functioning after combined myo-inositol, probiotics, micronutrient supplementation from preconception: Findings from the NiPPeR RCT. Psychiatry Res. 2024;334:115813. 10.1016/j.psychres.2024.115813
- Derkaczew M, Martyniuk P, Osowski A, Wojtkiewicz J. Cyclitols: From Basic Understanding to Their Association with Neurodegeneration. Nutrients. 2023;15. 10.3390/nu15092029
Data last updated:
