Suppressive effects of oral administration of heat-killed Lactobacillus acidophilus on T helper-17 immune responses in a bovine β-lactoglobulin-sensitized mice model.
We investigated how Lactobacillus acidophilus might affect allergy responses using a mouse model allergic to bovine β-lactoglobulin. The mice received varying doses of heat-killed L. acidophilus over several weeks prior to allergen exposure.
Our findings revealed that this treatment significantly reduced allergic reactions, including less inflammation and lower levels of IgE. We observed shifts in immune markers indicating improved balance in immune responses.
However, while there were beneficial effects observed, the overall significance of these findings needs further research.
Read More
9
Bifidobacterium bifidum improves CMPA
Bifidobacterium bifidum TMC3115 ameliorates milk protein allergy in by affecting gut microbiota: A randomized double-blind control trial.
We explored how Bifidobacterium bifidum TMC3115 could help infants with cow's milk protein allergy (CMPA). In our controlled trial with 256 infants, half received B. bifidum while the other half received a placebo.
Over six months, we observed significant reductions in allergic scores and improvements in anti-inflammatory responses among those taking B. bifidum. We also found changes in gut microbiota, increasing beneficial bacteria and decreasing potentially harmful ones.
Though promising, these interventions indicate that managing CMPA may benefit from focusing on gut health.
Read More
7
Lactobacillus salivarius lowers allergy symptoms
Effect of probiotics on allergic rhinitis in Df, Dp or dust-sensitive children: a randomized double blind controlled trial.
We explored the impact of Lactobacillus salivarius on allergic rhinitis symptoms in children through a double-blind, randomized controlled trial. Over 12 weeks, children either received the probiotic or a placebo.
Results showed a decrease in rhinitis symptoms and medication usage in those treated with the probiotic. However, there were no significant changes in immunological or blood cell measures when comparing the two groups.
Overall, Lactobacillus salivarius may be beneficial for reducing symptoms of allergic rhinitis in children.
Read More
Most Useful Reviews
9
Minimises allergies
212 people found this helpful
Very good probiotics! This product contains four essential bacteria types at a good concentration. I noticed improved skin and reduced allergies in my child after giving him one capsule. It has helped immensely with his digestion issues from birth. I highly recommend it for anyone looking to boost immunity and minimise allergies!
Read More
9
Helps with allergies
103 people found this helpful
Super! These capsules have been the best I've tried. I struggled with constipation and allergies for years, but after five days of taking these, my eczema improved and my nasal congestion cleared. I began giving them to my child as well, and his chair improved. I highly recommend this product for immune support and allergy relief.
Read More
9
Improves skin allergies
42 people found this helpful
My intestines have been problematic, causing allergies and bloating. After taking these probiotics, my skin improved dramatically in a couple of days. I wish I had started with these earlier, and I'm grateful to have found a product that suits me.
We examined if a specific blend of probiotics could alleviate symptoms of Allergic Rhinitis (AR). This randomized controlled trial compared a probiotic group to a placebo over eight weeks, tracking changes in allergy symptoms and gut health.
We found that those taking probiotics noted significant improvements in quality of life scores at all evaluated time points. Additionally, the probiotics seemed to alter gut bacteria favorably, reducing inflammation associated with allergies.
However, more research is necessary to fully understand these benefits and their long-term effects.
Read More
9
Symbiotic supplements reduce allergy symptoms
First evaluation of a symbiotic food supplement in an allergen exposure chamber in birch pollen allergic patients.
We investigated the effects of a symbiotic food supplement on individuals suffering from birch pollen allergy. Utilizing an allergen exposure chamber, we monitored patients’ responses before and after four months of daily intake.
Findings showed significant improvements in symptoms, overall well-being, and good safety. The combination of probiotics and prebiotics was effective in relieving allergy symptoms, highlighting its potential as a useful complementary approach in managing allergic rhinitis.
Read More
9
Acidophilus reduces allergy symptoms
Suppressive effects of oral administration of heat-killed Lactobacillus acidophilus on T helper-17 immune responses in a bovine β-lactoglobulin-sensitized mice model.
We investigated how Lactobacillus acidophilus might affect allergy responses using a mouse model allergic to bovine β-lactoglobulin. The mice received varying doses of heat-killed L. acidophilus over several weeks prior to allergen exposure.
Our findings revealed that this treatment significantly reduced allergic reactions, including less inflammation and lower levels of IgE. We observed shifts in immune markers indicating improved balance in immune responses.
However, while there were beneficial effects observed, the overall significance of these findings needs further research.
Read More
9
Lactobacillus KBL409 reduces atopic dermatitis
Lactobacillus acidophilus KBL409 Ameliorates Atopic Dermatitis in a Mouse Model.
We explored the effects of Lactobacillus acidophilus KBL409 on atopic dermatitis (AD) using a house dust mite-induced mouse model. The treatment notably lowered dermatitis symptoms and reduced immune cell infiltration in the skin. Additionally, it decreased levels of specific immune markers and increased anti-inflammatory responses.
L. acidophilus KBL409 also positively influenced gut microbiota and certain metabolites. The findings suggest that this probiotic may offer a promising approach to managing AD through immune system modulation and gut health improvement.
Read More
9
Lactobacillus Acidophilus shows promise
The Effect of Lactobacillus actobacillus Peptidoglycan on Bovine β-Lactoglobulin-Sensitized Mice via TLR2/NF-κB Pathway.
We investigated the effects of Lactobacillus acidophilus on allergies, particularly its peptidoglycan derived from dairy. In a mouse model of β-lactoglobulin allergy, we discovered that this peptidoglycan helped lower IgE production and promoted a healthier immune response. It also appeared to influence specific immune signaling pathways that help manage allergic reactions.
However, while the results showed promise, they were conducted in a controlled lab setting and further studies are needed to understand how these effects translate to humans.
Very good probiotics! This product contains four essential bacteria types at a good concentration. I noticed improved skin and reduced allergies in my child after giving him one capsule. It has helped immensely with his digestion issues from birth. I highly recommend it for anyone looking to boost immunity and minimise allergies!
Read More
9
Helps with allergies
103 people found this helpful
Super! These capsules have been the best I've tried. I struggled with constipation and allergies for years, but after five days of taking these, my eczema improved and my nasal congestion cleared. I began giving them to my child as well, and his chair improved. I highly recommend this product for immune support and allergy relief.
Read More
9
Improves skin allergies
42 people found this helpful
My intestines have been problematic, causing allergies and bloating. After taking these probiotics, my skin improved dramatically in a couple of days. I wish I had started with these earlier, and I'm grateful to have found a product that suits me.
Read More
9
No side effects
7 people found this helpful
These prebiotics are effective without causing side effects. My family takes them regularly, particularly during changes of season or after antibiotics. The results are impressive: improved digestion, reduced allergies, less bloating, and overall better health. I'll continue purchasing this product!
Read More
9
Restored microflora
4 people found this helpful
Excellent composition with a good effect on recovery. I highly recommend these probiotics for the family. After courses of antibiotics, my child's intestinal microflora suffered, leading to allergies like rashes and disrupted stools. I've made yogurt with these probiotics, which turned out thick and beneficial. We have taken them for a week now, and my child shows no signs of diarrhoea or allergies, even after eating sweets.
Allergies are the body's immune system responses to substances known as allergens, which can be harmless in most individuals. When a person with allergies encounters these allergens, their immune system mistakenly identifies them as a threat and launches a response. This can lead to symptoms ranging from mild, such as sneezing, itching, and rashes, to severe reactions known as anaphylaxis, which can be life-threatening. Common allergens include pollen, pet dander, certain foods like nuts and shellfish, insect stings, and medications.
Managing allergies often involves avoiding known allergens and using medications such as antihistamines or corticosteroids to alleviate symptoms. In some cases, doctors might recommend allergy shots or immunotherapy to help patients build tolerance over time. If you suspect you have allergies, consulting with a healthcare professional for proper diagnosis and treatment options is crucial. Understanding your triggers and how to live with allergies can significantly improve your quality of life.
Acidophilus, scientifically known as Lactobacillus acidophilus, is a type of beneficial bacteria that is commonly found in the human gut, as well as in fermented foods like yogurt and dietary supplements. This probiotic strain plays a crucial role in maintaining gut health by aiding digestion, enhancing nutrient absorption, and supporting the immune system. It is particularly known for its ability to break down lactose, making it easier for lactose-intolerant individuals to digest dairy products.
In addition to its digestive benefits, acidophilus has been studied for its potential to prevent or alleviate certain gastrointestinal issues, such as diarrhea and irritable bowel syndrome (IBS). Some research also suggests that it may support vaginal health by helping to maintain a balanced microbiome in women. When selecting a probiotic supplement that contains acidophilus, it is essential to look for products that contain live and active cultures, ensuring that you receive the full benefits of this beneficial bacteria. Always consult with a healthcare professional before beginning any new supplement regimen.
While Acidophilus, a strain of probiotic bacteria commonly found in yogurt and other fermented foods, is renowned for its digestive health benefits, its role in alleviating allergies is still being researched. Some studies suggest that probiotics, including Acidophilus, may help modulate the immune system and could potentially reduce the severity of allergic reactions by promoting a healthier gut microbiome. The theory is that a balanced gut flora may influence immune responses, leading to improved tolerance to allergens.
However, evidence remains inconclusive, and while some individuals report feeling better after incorporating probiotics into their diet, more rigorous clinical trials are necessary to establish a direct link between Acidophilus and allergy relief. If you’re considering Acidophilus or other probiotics to manage allergies, consulting with a healthcare provider is a good starting point. They can offer personalized advice and help you navigate any potential interactions with existing treatments or medications.
Based on user reviews, the timeline for seeing results from this supplement for allergies varies but often falls within a week to three months. Many users report noticeable improvements in their allergy symptoms in as little as five days. One reviewer mentioned significant relief from eczema and nasal congestion after this short period of use (Read Review). Other users indicate that they began experiencing better outcomes within one to two weeks, such as reduced sneezing episodes and improved digestion, which can indirectly alleviate allergy issues (Read Review).
On the longer end of the spectrum, some customers note that maximum benefits may take up to three months of consistent use, particularly in cases where allergies were exacerbated by previous use of antibiotics (Read Review). This comprehensive feedback suggests that while some may experience quick relief, others might need to maintain a longer course of supplementation for optimal results.
Numerous studies suggest that probiotics, particularly strains like Lactobacillus acidophilus and Bifidobacterium bifidum, may hold promise for alleviating allergy symptoms. For instance, a randomized controlled trial observed that individuals suffering from allergic rhinitis reported significant symptom improvements while using a specific blend of probiotics compared to a placebo [1]. Another study found that a synbiotic supplement combining probiotics and prebiotics effectively relieved symptoms of birch pollen allergies, further indicating these supplements' potential as complementary treatments for allergic rhinitis [2].
Moreover, probiotic strains like Lactobacillus acidophilus have been shown to modify immune responses related to allergies, reducing symptoms in both animal models and human studies. For example, one study noted that L. acidophilus decreased allergic reactions by altering gut microbiota and impacting inflammatory pathways [3]. While the current research provides a promising outlook on probiotics' roles in managing allergies, further investigation is essential to clarify their efficacy and optimal formulations [6].
Based on user reviews, many individuals have reported a notable improvement in allergy symptoms after using these probiotics. Parents in particular have mentioned enhancements in their children's conditions, such as reduced eczema and diminished nasal congestion within just a few days of starting the regimen (Read Review). Other users have reported significant relief from symptoms linked to allergies, including less sneezing and improved skin health, which some attributed to restored gut health. For instance, one user observed a considerable reduction in bloating and allergy responses, such as a runny nose, after incorporating the probiotics into their routine (Read Review).
While many users saw positive changes relatively quickly, some noted that the full benefits became apparent only after consistent use for several months. For instance, individuals recovering from the effects of antibiotics appreciated the gradual improvement in their gut and overall health, leading to a decrease in allergy symptoms over time (Read Review). However, it is essential to remember that individual results can vary, and what works well for one person might not yield the same effects for another.
Users have reported positive experiences when combining this supplement with other dietary interventions to manage allergies. For instance, some parents have shared that they integrated these probiotics into their children's diets along with homemade yogurt, which not only enhanced gut health but also alleviated allergy symptoms such as rashes and nasal congestion (Read Review, Read Review). Several users mentioned taking probiotics alongside other vitamins, noting improvements in immune response and overall health, particularly during allergy seasons (Read Review).
Moreover, individuals recovering from antibiotic treatment have found combining probiotics with their regular diet effective in restoring gut health, which has resulted in the reduction of allergy symptoms. This notion is echoed in reviews where users indicate a substantial decrease in bloating and clearer nasal passages over time (Read Review). Overall, user feedback supports that the synergistic effect of probiotics with other healthful practices can lead to notable improvements in managing allergies.
Users have reported varying doses of Acidophilus for treating allergies, with many finding success at a rate of one capsule per day. For example, one reviewer noted improvements in their child's allergies after administering a single capsule, which also helped with digestion issues (Read Review). Another user indicated that similar effects were observed within five days of daily use, leading to clearer skin and reduced nasal congestion, suggesting that consistent dosage may contribute to effective results (Read Review). Additionally, one reviewer mentioned using the probiotic to improve their young child’s gut health, mixing it into their formula once daily with satisfactory outcomes (Read Review).
Many testimonials highlight the importance of using Acidophilus regularly, particularly after courses of antibiotics, which can disrupt gut flora and exacerbate allergy symptoms. One user shared their experience of taking the probiotic over a three-month period and noticed significant improvements, particularly in preventing allergies (Read Review). Overall, users consistently express that a daily dose of one capsule has proven beneficial for optimizing gut health and alleviating allergy symptoms.
9
Helps with allergies
103 people found this helpful
Super! These capsules have been the best I've tried. I struggled with constipation and allergies for years, but after five days of taking these, my eczema improved and my nasal congestion cleared. I began giving them to my child as well, and his chair improved. I highly recommend this product for immune support and allergy relief.
7.5
Unknown allergy relief
1 people found this helpful
I suffered from an allergy of unknown cause for over a year. After starting these probiotics, my bowel movements improved, which reduced my sneezing episodes. It's better for my health than antihistamines.
9
Allergy rash vanished
1 people found this helpful
After antibiotics, my child developed numerous allergies. We were advised to try probiotics to restore his intestines. After three months, we've made yoghurt and have successfully managed to lessen the allergies.
7.5
Nose allergies improved
4 people found this helpful
After long use, my nose allergies have greatly improved. I no longer sneeze or have a runny nose in the mornings, contributing to overall better health.
9
Restored microflora
4 people found this helpful
Excellent composition with a good effect on recovery. I highly recommend these probiotics for the family. After courses of antibiotics, my child's intestinal microflora suffered, leading to allergies like rashes and disrupted stools. I've made yogurt with these probiotics, which turned out thick and beneficial. We have taken them for a week now, and my child shows no signs of diarrhoea or allergies, even after eating sweets.
7.5
Effective for allergies
942 people found this helpful
Excellent composition and great probiotics! After two courses of antibiotics, my child developed various allergies, and we were limited in what he could eat. A doctor suggested a course of probiotics to restore gut health. I chose these stabilised capsules, which don't require special storage. We've used them for almost three months, and now I can make tasty yogurts with prebiotics, which have improved my child's condition significantly!
7.5
Immunity maintenance
1 people found this helpful
I take this for myself and my teenage son to maintain immunity alongside vitamins. It’s also effective for allergies.
9
No side effects
7 people found this helpful
These prebiotics are effective without causing side effects. My family takes them regularly, particularly during changes of season or after antibiotics. The results are impressive: improved digestion, reduced allergies, less bloating, and overall better health. I'll continue purchasing this product!
9
Minimises allergies
212 people found this helpful
Very good probiotics! This product contains four essential bacteria types at a good concentration. I noticed improved skin and reduced allergies in my child after giving him one capsule. It has helped immensely with his digestion issues from birth. I highly recommend it for anyone looking to boost immunity and minimise allergies!
9
Resolved allergy
Excellent! My child, aged 1 year and 3 months, has surprisingly overcome her allergy. I mixed it into her infant formula once daily and we were pleased with the results.
7.5
Improves allergies
17 people found this helpful
After using this probiotic for three months, my family has noticed significant improvements in our health, including the restoration needed post-antibiotics. We enjoy making wholesome yogurts, and this product has been invaluable for addressing intestinal microbiota issues, particularly in preventing allergies.
9
Probiotics improve allergic rhinitis symptoms
Clinical Efficacy of Probiotics for Allergic Rhinitis: Results of an Exploratory Randomized Controlled Trial.
We examined if a specific blend of probiotics could alleviate symptoms of Allergic Rhinitis (AR). This randomized controlled trial compared a probiotic group to a placebo over eight weeks, tracking changes in allergy symptoms and gut health.
We found that those taking probiotics noted significant improvements in quality of life scores at all evaluated time points. Additionally, the probiotics seemed to alter gut bacteria favorably, reducing inflammation associated with allergies.
However, more research is necessary to fully understand these benefits and their long-term effects.
9
Symbiotic supplements reduce allergy symptoms
First evaluation of a symbiotic food supplement in an allergen exposure chamber in birch pollen allergic patients.
We investigated the effects of a symbiotic food supplement on individuals suffering from birch pollen allergy. Utilizing an allergen exposure chamber, we monitored patients’ responses before and after four months of daily intake.
Findings showed significant improvements in symptoms, overall well-being, and good safety. The combination of probiotics and prebiotics was effective in relieving allergy symptoms, highlighting its potential as a useful complementary approach in managing allergic rhinitis.
7
Probiotic shows potential allergy benefits
Modulation effect of Lactobacillus acidophilus KLDS 1.0738 on gut microbiota and TLR4 expression in β-lactoglobulin-induced allergic mice model.
We used a study involving β-lactoglobulin-sensitized mice to explore how Lactobacillus acidophilus KLDS 1.0738 influences allergies.
Our findings revealed that this probiotic might help reduce allergic reactions by altering gut bacteria and regulating Toll-like receptor signaling.
Specifically, we saw improved diversity in gut microbiota and decreased expression of certain inflammatory markers, which suggests a potential protective effect against allergies.
However, while results are promising, more research is needed to determine the full impact on human allergies.
8
Acidophilus shows potential in allergies
Effect of Lactobacillus acidophilus KLDS 1.0738 on miRNA expression in in vitro and in vivo models of β-lactoglobulin allergy.
We investigated how Lactobacillus acidophilus might help with β-lactoglobulin allergies by looking at its impact on specific immune responses. Using an allergic mouse model and cultured immune cells, we found that acidophilus treatment reduced hypersensitivity reactions and altered the expression of certain miRNAs linked to allergy development.
While the results showed promising suppression of allergy symptoms and relevant immune markers, we did not observe universal benefits for all tested aspects. Overall, it seems that acidophilus could play a role in managing allergy responses, especially related to certain miRNAs.
References
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Bergmann KC, Krause L, Hiller J, Becker S, Kugler S, et al. First evaluation of a symbiotic food supplement in an allergen exposure chamber in birch pollen allergic patients. World Allergy Organ J. 2021;14:100494. 10.1016/j.waojou.2020.100494
Ni WW, Zhang QM, Zhang X, Li Y, Yu SS, et al. Modulation effect of Lactobacillus acidophilus KLDS 1.0738 on gut microbiota and TLR4 expression in β-lactoglobulin-induced allergic mice model. Allergol Immunopathol (Madr). 2020;48:149. 10.1016/j.aller.2019.06.002
Wang JJ, Zhang QM, Ni WW, Zhang X, Li Y, et al. Modulatory effect of Lactobacillus acidophilus KLDS 1.0738 on intestinal short-chain fatty acids metabolism and GPR41/43 expression in β-lactoglobulin-sensitized mice. Microbiol Immunol. 2019;63:303. 10.1111/1348-0421.12723
Nakata J, Hirota T, Umemura H, Nakagawa T, Kando N, et al. Additive effect of L-92 on children with atopic dermatitis concomitant with food allergy. Asia Pac Allergy. 2019;9:e18. 10.5415/apallergy.2019.9.e18
Wang JJ, Li SH, Li AL, Zhang QM, Ni WW, et al. Effect of Lactobacillus acidophilus KLDS 1.0738 on miRNA expression in in vitro and in vivo models of β-lactoglobulin allergy. Biosci Biotechnol Biochem. 2018;82:1955. 10.1080/09168451.2018.1495551
Toomer OT, Ferguson M, Pereira M, Do A, Bigley E, et al. Maternal and postnatal dietary probiotic supplementation enhances splenic regulatory T helper cell population and reduces ovalbumin allergen-induced hypersensitivity responses in mice. Immunobiology. 2014;219:367. 10.1016/j.imbio.2014.01.003
Li AL, Meng XC, Duan CC, Huo GC, Zheng QL, et al. Suppressive effects of oral administration of heat-killed Lactobacillus acidophilus on T helper-17 immune responses in a bovine β-lactoglobulin-sensitized mice model. Biol Pharm Bull. 2013;36:202.
Shah MM, Miyamoto Y, Yamada Y, Yamashita H, Tanaka H, et al. Orally supplemented Lactobacillus acidophilus strain L-92 inhibits passive and active cutaneous anaphylaxis as well as 2,4-dinitroflurobenzene and mite fecal antigen induced atopic dermatitis-like skin lesions in mice. Microbiol Immunol. 2010;54:523. 10.1111/j.1348-0421.2010.00251.x
Penders J, Thijs C, Mommers M, Stobberingh EE, Dompeling E, et al. Intestinal lactobacilli and the DC-SIGN gene for their recognition by dendritic cells play a role in the aetiology of allergic manifestations. Microbiology (Reading). 2010;156:3298. 10.1099/mic.0.042069-0
Kim WK, Jang YJ, Park S, Min SG, Kwon H, et al. Lactobacillus acidophilus KBL409 Ameliorates Atopic Dermatitis in a Mouse Model. J Microbiol. 2024;62:91. 10.1007/s12275-024-00104-5
Husein-ElAhmed H, Steinhoff M. Effects of probiotic supplementation in adult with atopic dermatitis: a systematic review with meta-analysis. Clin Exp Dermatol. 2023;49:46. 10.1093/ced/llad318
Li A, Yang J, Zhang C, Chi H, Zhang C, et al. Lactobacillus acidophilus KLDS 1.0738 inhibits TLR4/NF-κB inflammatory pathway in β-lactoglobulin-induced macrophages via modulating miR-146a. J Food Biochem. 2021;45:e13662. 10.1111/jfbc.13662
Tan-Lim CSC, Esteban-Ipac NAR, Mantaring JBV, Chan Shih Yen E, Recto MST, et al. Comparative effectiveness of probiotic strains for the treatment of pediatric atopic dermatitis: A systematic review and network meta-analysis. Pediatr Allergy Immunol. 2021;32:124. 10.1111/pai.13305
Li AL, Sun YQ, Du P, Meng XC, Guo L, et al. The Effect of Lactobacillus actobacillus Peptidoglycan on Bovine β-Lactoglobulin-Sensitized Mice via TLR2/NF-κB Pathway. Iran J Allergy Asthma Immunol. 2017;16:147.
Rø ADB, Simpson MR, Rø TB, Storrø O, Johnsen R, et al. Reduced Th22 cell proportion and prevention of atopic dermatitis in infants following maternal probiotic supplementation. Clin Exp Allergy. 2017;47:1014. 10.1111/cea.12930
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Yamamoto K, Yokoyama K, Matsukawa T, Kato S, Kato S, et al. Efficacy of prolonged ingestion of Lactobacillus acidophilus L-92 in adult patients with atopic dermatitis. J Dairy Sci. 2016;99:5039. 10.3168/jds.2015-10605
Shandilya UK, Sharma A, Kapila R, Kansal VK. Probiotic Dahi containing Lactobacillus acidophilus and Bifidobacterium bifidum modulates immunoglobulin levels and cytokines expression in whey proteins sensitised mice. J Sci Food Agric. 2016;96:3180. 10.1002/jsfa.7497
Simpson MR, Dotterud CK, Storrø O, Johnsen R, Øien T. Perinatal probiotic supplementation in the prevention of allergy related disease: 6 year follow up of a randomised controlled trial. BMC Dermatol. 2015;15:13. 10.1186/s12895-015-0030-1
Lin TJ, Huang CC, Lee MC, Lee YP, Huang WC, et al. Effects of ssp. SA-03 Supplementation on Reversing Phthalate-Induced Asthma in Mice. Nutrients. 2024;16. 10.3390/nu16081160
Yang S, Peng Z, Hardie WJ, Huang T, Tang H, et al. Screening of probiotic Lactobacillus to reduce peanut allergy and with potential anti-allergic activity. J Sci Food Agric. 2024;104:2006. 10.1002/jsfa.13089
Uwaezuoke SN, Ayuk AC, Eze JN, Odimegwu CL, Ndiokwelu CO, et al. Postnatal probiotic supplementation can prevent and optimize treatment of childhood asthma and atopic disorders: A systematic review of randomized controlled trials. Front Pediatr. 2022;10:956141. 10.3389/fped.2022.956141
Holowacz S, Blondeau C, Guinobert I, Guilbot A, Hidalgo S, et al. Lactobacillus salivarius LA307 and Lactobacillus rhamnosus LA305 attenuate skin inflammation in mice. Benef Microbes. 2018;9:299. 10.3920/BM2017.0084
Nettis E, Di Leo E, Pastore A, Distaso M, Zaza I, et al. Probiotics and refractory chronic spontaneous urticaria. Eur Ann Allergy Clin Immunol. 2016;48:182.
Neau E, Delannoy J, Marion C, Cottart CH, Labellie C, et al. Three Novel Candidate Probiotic Strains with Prophylactic Properties in a Murine Model of Cow's Milk Allergy. Appl Environ Microbiol. 2016;82:1722. 10.1128/AEM.03440-15
Yun X, Shang Y, Li M. Effect of Lactobacillus salivarius on Th1/Th2 cytokines and the number of spleen CD4⁺ CD25⁺ Foxp3⁺ Treg in asthma Balb/c mouse. Int J Clin Exp Pathol. 2015;8:7661.
Drago L, De Vecchi E, Gabrieli A, De Grandi R, Toscano M. Immunomodulatory Effects of Lactobacillus salivarius LS01 and Bifidobacterium breve BR03, Alone and in Combination, on Peripheral Blood Mononuclear Cells of Allergic Asthmatics. Allergy Asthma Immunol Res. 2015;7:409. 10.4168/aair.2015.7.4.409
Drago L, De Vecchi E, Toscano M, Vassena C, Altomare G, et al. Treatment of atopic dermatitis eczema with a high concentration of Lactobacillus salivarius LS01 associated with an innovative gelling complex: a pilot study on adults. J Clin Gastroenterol. 2014;48 Suppl 1:S47. 10.1097/MCG.0000000000000249
Niccoli AA, Artesi AL, Candio F, Ceccarelli S, Cozzali R, et al. Preliminary results on clinical effects of probiotic Lactobacillus salivarius LS01 in children affected by atopic dermatitis. J Clin Gastroenterol. 2014;48 Suppl 1:S34. 10.1097/MCG.0000000000000233
Allen SJ, Jordan S, Storey M, Thornton CA, Gravenor MB, et al. Probiotics in the prevention of eczema: a randomised controlled trial. Arch Dis Child. 2014;99:1014. 10.1136/archdischild-2013-305799
Drago L, Toscano M, De Vecchi E, Piconi S, Iemoli E. Changing of fecal flora and clinical effect of L. salivarius LS01 in adults with atopic dermatitis. J Clin Gastroenterol. 2012;46 Suppl:S56. 10.1097/MCG.0b013e318265ef38
Iemoli E, Trabattoni D, Parisotto S, Borgonovo L, Toscano M, et al. Probiotics reduce gut microbial translocation and improve adult atopic dermatitis. J Clin Gastroenterol. 2012;46 Suppl:S33. 10.1097/MCG.0b013e31826a8468
Lin TY, Chen CJ, Chen LK, Wen SH, Jan RH. Effect of probiotics on allergic rhinitis in Df, Dp or dust-sensitive children: a randomized double blind controlled trial. Indian Pediatr. 2013;50:209.
Anania C, Matys V, Marra S, De Canditiis D, Olivero F, et al. Effect of Supplementation with a Specific Probiotic ( PRL2010) in Pregnancy for the Prevention of Atopic Dermatitis in Children: Preliminary Results of a Randomized Trial. Nutrients. 2025;17. 10.3390/nu17040673
Chan OM, Xu W, Cheng NS, Leung ASY, Ching JYL, et al. A novel infant microbiome formula (SIM03) improved eczema severity and quality of life in preschool children. Sci Rep. 2024;14:3168. 10.1038/s41598-024-53848-w
Jing W, Liu Q, Wang W. Bifidobacterium bifidum TMC3115 ameliorates milk protein allergy in by affecting gut microbiota: A randomized double-blind control trial. J Food Biochem. 2020;44:e13489. 10.1111/jfbc.13489
Cheng R, Guo J, Pu F, Wan C, Shi L, et al. Loading ceftriaxone, vancomycin, and Bifidobacteria bifidum TMC3115 to neonatal mice could differently and consequently affect intestinal microbiota and immunity in adulthood. Sci Rep. 2019;9:3254. 10.1038/s41598-018-35737-1
Suzuki S, Campos-Alberto E, Morita Y, Yamaguchi M, Toshimitsu T, et al. Low Interleukin 10 Production at Birth Is a Risk Factor for Atopic Dermatitis in Neonates with Bifidobacterium Colonization. Int Arch Allergy Immunol. 2018;177:342. 10.1159/000492130
Cheng RY, Yao JR, Wan Q, Guo JW, Pu FF, et al. Oral administration of Bifidobacterium bifidum TMC3115 to neonatal mice may alleviate IgE-mediated allergic risk in adulthood. Benef Microbes. 2018;9:815. 10.3920/BM2018.0005
Dennis-Wall JC, Culpepper T, Nieves C, Rowe CC, Burns AM, et al. Probiotics ( KS-13, G9-1, and MM-2) improve rhinoconjunctivitis-specific quality of life in individuals with seasonal allergies: a double-blind, placebo-controlled, randomized trial. Am J Clin Nutr. 2017;105:758. 10.3945/ajcn.116.140012
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