Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.4
USERS' SCORE
Good
Based on 2 Reviews
8.6
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol)
13 mcg (500 IU)
63%
Calcium (as Calcium Citrate)
630 mg
48%
Top Medical Research Studies
2
We conducted a thorough investigation into how vitamin D3 supplementation affects diarrhea in young children. The study involved 3,046 infants aged 1 to 11 months living in high-risk areas of Kabul, Afghanistan. They were randomly assigned to receive either six doses of vitamin D3 or a placebo over 18 months.
Our analysis measured instances of diarrhea, defined as having three or more loose stools in a single day. We focused on comparing the time to the first diarrhea episode and the risk of recurring episodes between both groups.
However, the results were quite clear: vitamin D3 supplementation did not lead to any significant reduction in the time before the first episode of diarrhea or in the likelihood of having recurrent diarrhea. The differences observed between the vitamin D3 group and the placebo group were not meaningful.
Despite our expectations, this study suggests that vitamin D3 supplementation doesn't provide the preventive benefits we were hoping for when it comes to diarrhea in this population. We recommend against using similar supplementation under comparable circumstances without further research.
Additional studies in other settings might help in understanding if vitamin D3 could play a beneficial role in preventing diarrhea elsewhere.
Our analysis measured instances of diarrhea, defined as having three or more loose stools in a single day. We focused on comparing the time to the first diarrhea episode and the risk of recurring episodes between both groups.
However, the results were quite clear: vitamin D3 supplementation did not lead to any significant reduction in the time before the first episode of diarrhea or in the likelihood of having recurrent diarrhea. The differences observed between the vitamin D3 group and the placebo group were not meaningful.
Despite our expectations, this study suggests that vitamin D3 supplementation doesn't provide the preventive benefits we were hoping for when it comes to diarrhea in this population. We recommend against using similar supplementation under comparable circumstances without further research.
Additional studies in other settings might help in understanding if vitamin D3 could play a beneficial role in preventing diarrhea elsewhere.
Read More
9
We examined how the vitamin D analog TX527 affects diarrhea in a model of inflammatory bowel disease (IBD) induced by dextran sodium sulfate (DSS). In our study, we observed that TX527 significantly improved disease symptoms by reducing both bleeding and diarrhea.
Notably, this analog also enhanced colon length, indicating a positive effect on the health of the intestines. Histological analysis revealed that TX527 helped protect mucosal integrity and reduced immune cell infiltration, which are key factors in IBD.
Furthermore, we found that TX527 led to a decrease in levels of several inflammatory cytokines like IL-1, IL-6, IFN-γ, and TNF-α in the colonic tissue. This suggests that the treatment not only alleviates the symptoms but also targets the underlying inflammation associated with diarrhea in IBD.
In conclusion, our findings highlight the potential of TX527 as a therapeutic option for managing diarrhea in inflammatory bowel disease.
Notably, this analog also enhanced colon length, indicating a positive effect on the health of the intestines. Histological analysis revealed that TX527 helped protect mucosal integrity and reduced immune cell infiltration, which are key factors in IBD.
Furthermore, we found that TX527 led to a decrease in levels of several inflammatory cytokines like IL-1, IL-6, IFN-γ, and TNF-α in the colonic tissue. This suggests that the treatment not only alleviates the symptoms but also targets the underlying inflammation associated with diarrhea in IBD.
In conclusion, our findings highlight the potential of TX527 as a therapeutic option for managing diarrhea in inflammatory bowel disease.
Read More
7
We investigated whether vitamin D3, specifically in the form of synthetic 25-OH-cholecalciferol, could help reduce diarrhea during an acute campylobacter infection. Using a controlled study involving IL-10 mice, we treated one group with vitamin D3 four days before they were infected with the bacteria, while another group received a placebo.
Our findings revealed that while vitamin D3 did not significantly lower the levels of gastrointestinal pathogens, it did lead to fewer instances of diarrhea among the treated mice compared to those receiving the placebo. Additionally, we observed that the vitamin D3 treatment seemed to help protect the mice's intestinal health; it reduced the inflammation and improved cell regeneration in the colonic area.
Interestingly, vitamin D3 also contributed to a lower immune response in the infected mice. There were fewer immune cells and lower levels of inflammatory mediators when compared to the placebo group. Perhaps most importantly, the application of vitamin D3 resulted in a reduced risk of the bacteria spreading from the inflamed intestines to other parts of the body, such as the kidneys and spleen, and helped maintain a healthier intestinal barrier.
In summary, our study suggests that taking synthetic vitamin D3 can have beneficial effects during acute campylobacteriosis, particularly in managing diarrhea and preserving gut health.
Our findings revealed that while vitamin D3 did not significantly lower the levels of gastrointestinal pathogens, it did lead to fewer instances of diarrhea among the treated mice compared to those receiving the placebo. Additionally, we observed that the vitamin D3 treatment seemed to help protect the mice's intestinal health; it reduced the inflammation and improved cell regeneration in the colonic area.
Interestingly, vitamin D3 also contributed to a lower immune response in the infected mice. There were fewer immune cells and lower levels of inflammatory mediators when compared to the placebo group. Perhaps most importantly, the application of vitamin D3 resulted in a reduced risk of the bacteria spreading from the inflamed intestines to other parts of the body, such as the kidneys and spleen, and helped maintain a healthier intestinal barrier.
In summary, our study suggests that taking synthetic vitamin D3 can have beneficial effects during acute campylobacteriosis, particularly in managing diarrhea and preserving gut health.
Read More
Most Useful Reviews
9.5
No discomfort noted
This calcium has been taken for some time without any discomfort or diarrhoea. It is calcium citrate, which is easy to absorb. Taking 2 tablets a day provides 630mg of calcium. Additionally, it contains D3 to assist with calcium absorption. The price is reasonable. It is my preferred choice for calcium supplements. Recommended! (However, the particles are somewhat large, so those with swallowing difficulties should choose carefully.)
Read More
8.8
Diarrhea prevented
This magnesium-free formula works well as relatives and friends often avoid the sun, yet many vitamin D3 complex calcium tablets contain added magnesium. When she consumed those complex calcium tablets, she experienced mild diarrhoea. Switching to this calcium tablet containing only calcium and vitamin D3, without magnesium, resulted in no diarrhoea. Additionally, a bottle of these calcium citrate tablets, which contains 400 tablets, is also very affordable.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.4
- All Researches
9
We conducted a study to see how supplementing weaned pigs with 25-hydroxyvitamin D (25(OH)D) could help ease diarrhea linked to porcine epidemic diarrhea virus (PEDV) infection. Forty-two pigs were divided into six groups and fed different amounts of vitamin D3 for 26 days. On day 22, we introduced the virus to all but one control group, which only received saline.
Our findings were quite striking. We noted that pig weight gain significantly dropped due to the PEDV infection, which also led to severe diarrhea. This infection negatively impacted the pigs' gut health by reducing villous height and increasing crypt depth—a clear indicator of intestinal distress. However, in the group supplemented with the highest level of vitamin D3 (155.5 μg), we observed considerable improvements. Their intestinal damage was significantly less than that of the control group exposed to PEDV.
Furthermore, the vitamin D3 supplementation helped lower the presence of inflammatory markers in the pigs’ systems, suggesting that this vitamin plays a role in modulating the immune response. Overall, our results indicate that adding 25(OH)D to pig diets can be beneficial in reducing diarrhea and supporting gut health in the face of PEDV infection.
Our findings were quite striking. We noted that pig weight gain significantly dropped due to the PEDV infection, which also led to severe diarrhea. This infection negatively impacted the pigs' gut health by reducing villous height and increasing crypt depth—a clear indicator of intestinal distress. However, in the group supplemented with the highest level of vitamin D3 (155.5 μg), we observed considerable improvements. Their intestinal damage was significantly less than that of the control group exposed to PEDV.
Furthermore, the vitamin D3 supplementation helped lower the presence of inflammatory markers in the pigs’ systems, suggesting that this vitamin plays a role in modulating the immune response. Overall, our results indicate that adding 25(OH)D to pig diets can be beneficial in reducing diarrhea and supporting gut health in the face of PEDV infection.
Read More
9
We examined how the vitamin D analog TX527 affects diarrhea in a model of inflammatory bowel disease (IBD) induced by dextran sodium sulfate (DSS). In our study, we observed that TX527 significantly improved disease symptoms by reducing both bleeding and diarrhea.
Notably, this analog also enhanced colon length, indicating a positive effect on the health of the intestines. Histological analysis revealed that TX527 helped protect mucosal integrity and reduced immune cell infiltration, which are key factors in IBD.
Furthermore, we found that TX527 led to a decrease in levels of several inflammatory cytokines like IL-1, IL-6, IFN-γ, and TNF-α in the colonic tissue. This suggests that the treatment not only alleviates the symptoms but also targets the underlying inflammation associated with diarrhea in IBD.
In conclusion, our findings highlight the potential of TX527 as a therapeutic option for managing diarrhea in inflammatory bowel disease.
Notably, this analog also enhanced colon length, indicating a positive effect on the health of the intestines. Histological analysis revealed that TX527 helped protect mucosal integrity and reduced immune cell infiltration, which are key factors in IBD.
Furthermore, we found that TX527 led to a decrease in levels of several inflammatory cytokines like IL-1, IL-6, IFN-γ, and TNF-α in the colonic tissue. This suggests that the treatment not only alleviates the symptoms but also targets the underlying inflammation associated with diarrhea in IBD.
In conclusion, our findings highlight the potential of TX527 as a therapeutic option for managing diarrhea in inflammatory bowel disease.
Read More
8
We evaluated the effects of vitamin D3, specifically 1,25-dihydroxyvitamin D3, on the reproductive performance of sows and the health of their piglets, focusing on incidences of diarrhea. In our study, we assessed two experiments involving 320 sows divided into different dietary treatments, including control groups without vitamin D3 or capsaicin (CAP).
The results indicated that sows supplemented with vitamin D3 showed a reduction in diarrhea cases among their piglets compared to those in the control group. In fact, the use of these dietary additives, including CAP, seemed to enhance the overall health of the piglets, which we found particularly important for litter growth.
While it is worth noting that vitamin D3 was combined with capsaicin in the treatment groups, making it challenging to delineate the effects of vitamin D3 alone, our findings directly suggest that including vitamin D3 in sow diets positively contributes to piglet health by lowering the incidence of diarrhea.
The results indicated that sows supplemented with vitamin D3 showed a reduction in diarrhea cases among their piglets compared to those in the control group. In fact, the use of these dietary additives, including CAP, seemed to enhance the overall health of the piglets, which we found particularly important for litter growth.
While it is worth noting that vitamin D3 was combined with capsaicin in the treatment groups, making it challenging to delineate the effects of vitamin D3 alone, our findings directly suggest that including vitamin D3 in sow diets positively contributes to piglet health by lowering the incidence of diarrhea.
Read More
8
We explored how Vitamin D, alongside carbamazepine, affects the body’s defense against Clostridioides difficile infection (CDI), a leading cause of severe diarrhea in hospitals. The study examined how Clostridial toxin B (TcdB) impacts macrophage function, which plays a crucial role in our immune response. In particular, researchers looked at whether TcdB reduces the acidity of lysosomes within macrophages, leading to increased inflammation and tissue damage.
Our findings shed light on how restoring lysosomal function with Vitamin D and carbamazepine could help combat this inflammation and damage. We noticed that both treatments were able to mitigate TcdB-induced dysfunction in mice, thereby reducing inflammation and histological harm.
However, it is important to note that while the study provides evidence for the protective role of Vitamin D and carbamazepine in the context of CDI, it does not isolate the effects of Vitamin D alone on diarrhea. This makes it difficult to determine whether Vitamin D3 by itself has a direct impact on reducing diarrhea. Overall, we observed promising results regarding immunity enhancement, but the specific effects on diarrhea require further investigation.
Our findings shed light on how restoring lysosomal function with Vitamin D and carbamazepine could help combat this inflammation and damage. We noticed that both treatments were able to mitigate TcdB-induced dysfunction in mice, thereby reducing inflammation and histological harm.
However, it is important to note that while the study provides evidence for the protective role of Vitamin D and carbamazepine in the context of CDI, it does not isolate the effects of Vitamin D alone on diarrhea. This makes it difficult to determine whether Vitamin D3 by itself has a direct impact on reducing diarrhea. Overall, we observed promising results regarding immunity enhancement, but the specific effects on diarrhea require further investigation.
Read More
8
Vitamin D3 aids viral infection response
We investigated how vitamin D3, specifically 1,25-dihydroxyvitamin D, interacts with porcine epidemic diarrhea virus (PEDV), which is known to cause severe gastrointestinal issues in pigs, including diarrhea. Our focus was to see if vitamin D3 could help in reducing PEDV replication, thereby mitigating its effects on the animals' health.
Through our research, we found that vitamin D3 supplementation diminished PEDV-induced cell damage and apoptosis in pig intestinal epithelial cells. Notably, we observed significant reductions in PEDV gene and protein levels in these cells after treatment with vitamin D3. These findings indicate a potential antiviral effect that warrants further investigation in the context of diarrhea management.
The study also revealed that vitamin D3 appears to help cells move past a phase that the virus exploits to replicate. This movement out of the G0/G1 phase was supported by the treatment of vitamin D3, marking an intriguing potential pathway for enhancing healing from PEDV-related conditions.
While we focused on viral context rather than general diarrhea treatments, the findings suggest that vitamin D3 might play a supportive role against viral infections that cause gastrointestinal distress, such as PEDV. Though more work is needed to see these effects in broader contexts, our study lays an important foundation for further exploration into vitamin D's benefits in viral infections.
Through our research, we found that vitamin D3 supplementation diminished PEDV-induced cell damage and apoptosis in pig intestinal epithelial cells. Notably, we observed significant reductions in PEDV gene and protein levels in these cells after treatment with vitamin D3. These findings indicate a potential antiviral effect that warrants further investigation in the context of diarrhea management.
The study also revealed that vitamin D3 appears to help cells move past a phase that the virus exploits to replicate. This movement out of the G0/G1 phase was supported by the treatment of vitamin D3, marking an intriguing potential pathway for enhancing healing from PEDV-related conditions.
While we focused on viral context rather than general diarrhea treatments, the findings suggest that vitamin D3 might play a supportive role against viral infections that cause gastrointestinal distress, such as PEDV. Though more work is needed to see these effects in broader contexts, our study lays an important foundation for further exploration into vitamin D's benefits in viral infections.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
No discomfort noted
This calcium has been taken for some time without any discomfort or diarrhoea. It is calcium citrate, which is easy to absorb. Taking 2 tablets a day provides 630mg of calcium. Additionally, it contains D3 to assist with calcium absorption. The price is reasonable. It is my preferred choice for calcium supplements. Recommended! (However, the particles are somewhat large, so those with swallowing difficulties should choose carefully.)
Read More
8.8
Diarrhea prevented
This magnesium-free formula works well as relatives and friends often avoid the sun, yet many vitamin D3 complex calcium tablets contain added magnesium. When she consumed those complex calcium tablets, she experienced mild diarrhoea. Switching to this calcium tablet containing only calcium and vitamin D3, without magnesium, resulted in no diarrhoea. Additionally, a bottle of these calcium citrate tablets, which contains 400 tablets, is also very affordable.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Dario JGN, de Oliveira ER, de Souza RP, Theodorovicz S, Bernini GC, et al. Capsaicin and 1,25-Dihydroxyvitamin D Glycoside: Effects on the Reproductive Performance of Hyper-Prolific Sows. Animals (Basel). 2023;13. doi:10.3390/ani13172794
- Yang J, Chen D, Tian G, Mao X, He J, et al. 1,25-Dihydroxyvitamin D Negatively Regulates the Inflammatory Response to Porcine Epidemic Diarrhea Virus Infection by Inhibiting NF-κB and JAK/STAT Signaling Pathway in IPEC-J2 Porcine Epithelial Cells. Int J Mol Sci. 2022;23. doi:10.3390/ijms231810603
- Chan H, Li Q, Wang X, Liu WY, Hu W, et al. Vitamin D and carbamazepine protect against infection in mice by restoring macrophage lysosome acidification. Autophagy. 2022;18:2050. doi:10.1080/15548627.2021.2016004
- Yang J, Tian G, Chen D, Mao X, He J, et al. 1,25-Dihydroxyvitamin D inhibits porcine epidemic diarrhea virus replication by regulating cell cycle resumption in IPEC-J2 porcine epithelial cells. Microb Pathog. 2021;158:105017. doi:10.1016/j.micpath.2021.105017
- Khalighi Sikaroudi M, Mokhtare M, Shidfar F, Janani L, Faghihi Kashani A, et al. Effects of vitamin D3 supplementation on clinical symptoms, quality of life, serum serotonin (5-hydroxytryptamine), 5-hydroxy-indole acetic acid, and ratio of 5-HIAA/5-HT in patients with diarrhea-predominant irritable bowel syndrome: A randomized clinical trial. EXCLI J. 2020;19:652. doi:10.17179/excli2020-2247
- Khalighi Sikaroudi M, Mokhtare M, Janani L, Faghihi Kashani AH, Masoodi M, et al. Vitamin D3 Supplementation in Diarrhea-Predominant Irritable Bowel Syndrome Patients: The Effects on Symptoms Improvement, Serum Corticotropin-Releasing Hormone, and Interleukin-6 - A Randomized Clinical Trial. Complement Med Res. 2020;27:302. doi:10.1159/000506149
- Mousavi S, Lobo de Sá FD, Schulzke JD, Bücker R, Bereswill S, et al. Vitamin D in Acute Campylobacteriosis-Results From an Intervention Study Applying a Clinical Induced Enterocolitis Model. Front Immunol. 2019;10:2094. doi:10.3389/fimmu.2019.02094
- Yang J, Tian G, Chen D, Zheng P, Yu J, et al. Dietary 25-Hydroxyvitamin D Supplementation Alleviates Porcine Epidemic Diarrhea Virus Infection by Improving Intestinal Structure and Immune Response in Weaned Pigs. Animals (Basel). 2019;9. doi:10.3390/ani9090627
- Bucak IH, Ozturk AB, Almis H, Cevik MÖ, Tekin M, et al. Is there a relationship between low vitamin D and rotaviral diarrhea?. Pediatr Int. 2016;58:270. doi:10.1111/ped.12809
- Zhang H, Wu H, Liu L, Li H, Shih DQ, et al. 1,25-dihydroxyvitamin D3 regulates the development of chronic colitis by modulating both T helper (Th)1 and Th17 activation. APMIS. 2015;123:490. doi:10.1111/apm.12378
- van der Wilden GM, Fagenholz PJ, Velmahos GC, Quraishi SA, Schipper IB, et al. Vitamin D status and severity of Clostridium difficile infections: a prospective cohort study in hospitalized adults. JPEN J Parenter Enteral Nutr. 2015;39:465. doi:10.1177/0148607113519129
- Aluisio AR, Maroof Z, Chandramohan D, Bruce J, Mughal MZ, et al. Vitamin D₃supplementation and childhood diarrhea: a randomized controlled trial. Pediatrics. 2013;132:e832. doi:10.1542/peds.2012-3986
- Verlinden L, Leyssens C, Beullens I, Marcelis S, Mathieu C, et al. The vitamin D analog TX527 ameliorates disease symptoms in a chemically induced model of inflammatory bowel disease. J Steroid Biochem Mol Biol. 2013;136:107. doi:10.1016/j.jsbmb.2012.09.017
- Duangjai A, Rawangkan A, Yosboonruang A, Ontawong A, Saokaew S, et al. Antispasmodic Activity of Light-Roasted Coffee Extract and Its Potential Use in Gastrointestinal Motility Disorders. Foods. 2024;13. doi:10.3390/foods13152307
