Overview

SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.4
USERS' SCORE
Good
Based on 3 Reviews
8.4
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol)
13 mcg (500 IU)
63%
Calcium (as Calcium Citrate)
630 mg
48%

Top Medical Research Studies

9
Vitamin D3 reduces thyroid autoimmunity
We explored the potential effects of vitamin D3, or cholecalciferol, on individuals diagnosed with Hashimoto's thyroiditis, a common form of hypothyroidism characterized by autoimmune responses that damage thyroid cells. Our study was a carefully structured clinical trial conducted over one year, which included 100 patients suffering from both Hashimoto's thyroiditis and vitamin D deficiency.

Divided into two groups, one received vitamin D3 supplements while the other was given a placebo. After eight weeks, we measured the levels of anti-thyroid peroxidase antibodies, which indicate autoimmune activity against the thyroid.

Our findings revealed a significant reduction in these antibody levels among patients who received vitamin D3, showcasing a 30.5% decrease compared to just a 16.5% decrease in the placebo group. This suggests that vitamin D3 supplementation may play a beneficial role in managing the autoimmune activity associated with hypothyroidism.

Overall, our research shows that addressing vitamin D deficiency might be an effective strategy to help manage Hashimoto's thyroiditis, which could encourage discussion about incorporating vitamin D as part of treatment plans for patients. Further research will be necessary to confirm these findings and explore the long-term benefits of vitamin D supplementation.
Read More
8
Vitamin D3 improves thyroid function
We evaluated the effects of vitamin D3 supplementation on hypothyroidism, specifically in patients with Hashimoto's thyroiditis (HT). Our analysis involved 12 randomized controlled trials, comparing the outcomes of individuals receiving vitamin D3 against those given a placebo or no treatment at all.

Through this thorough examination, we found that vitamin D3 did promote significant improvements in thyroid function and immune response. Specifically, we observed a reduction in two key antibodies: anti-thyroid peroxidase (TPO-Ab) and thyroglobulin antibody (TG-Ab). These reductions suggest a positive effect on the autoimmune process involved in Hashimoto's thyroiditis.

Additionally, we noted improvements in thyroid hormone levels, including free thyroxine (FT4) and free triiodothyronine (FT3), while thyroid-stimulating hormone (TSH) levels showed a decrease. These findings indicate that vitamin D3 supplementation may benefit thyroid health and help manage hypothyroidism more effectively.

For those considering vitamin D3 as a treatment option, particularly those who have been on vitamin D for longer than 12 weeks, the results suggest a more pronounced effect on improving antibody levels and thyroid function. Thus, there appears to be a compelling case for vitamin D3 as a supportive treatment in managing Hashimoto's thyroiditis and related hypothyroidism.
Read More
We evaluated the potential impact of vitamin D3 treatment on patients suffering from Hashimoto's thyroiditis, particularly looking at its effect on the development of hypothyroidism. Our investigation included 75 individuals diagnosed with this autoimmune disorder and a control group of 43 healthy participants. The results showed that patients with Hashimoto's thyroiditis had notably lower vitamin D levels compared to those without the condition.

To address vitamin D deficiency, we administered a weekly dose of 50,000 units of vitamin D3 to those who were lacking it for eight weeks. After this treatment, we observed significant improvements. Thyroid autoantibodies, which indicate inflammation and damage in the thyroid, decreased in those who were treated. Additionally, we found that levels of HDL cholesterol improved, suggesting potential benefits for cardiovascular health.

Our findings point toward vitamin D deficiency being common among those with Hashimoto's thyroiditis. By addressing this deficiency, we may slow down the progression toward hypothyroidism and reduce cardiovascular risks associated with the condition. Therefore, monitoring and supplementing vitamin D could play a crucial role in managing the health of these patients effectively.
Read More

Most Useful Reviews

9
Reduced muscle cramps
Calcium citrate has become an essential part of my routine and began working in just ten days. I take 6 tablets daily, along with alfacalcidol to enhance calcium absorption. The quality is excellent for a reasonable price. Following surgery for hypothyroidism and hypoparathyroidism, I noticed improved nerve conduction, and muscle twitching and cramps have ceased. This formulation has been suitable for me.
Read More
7.5
Hair growth improvement
2 people found this helpful
I received my doctor’s approval to take calcium for a couple of months. I am pleased with the noticeable growth of new hair and a reduction in hair loss. My nails began to improve in just a few weeks. My analysis results are within normal limits. Calcium is particularly necessary for those with hypothyroidism.
Read More
7.5
No side effects
My endocrinologist advised me to take calcium due to my hypothyroidism, alongside an artificial hormone. I find the calcium beneficial and experienced no side effects from its use.
Read More

Medical Researches

SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.4
  • All Researches
9
Vitamin D3 reduces thyroid autoimmunity
We explored the potential effects of vitamin D3, or cholecalciferol, on individuals diagnosed with Hashimoto's thyroiditis, a common form of hypothyroidism characterized by autoimmune responses that damage thyroid cells. Our study was a carefully structured clinical trial conducted over one year, which included 100 patients suffering from both Hashimoto's thyroiditis and vitamin D deficiency.

Divided into two groups, one received vitamin D3 supplements while the other was given a placebo. After eight weeks, we measured the levels of anti-thyroid peroxidase antibodies, which indicate autoimmune activity against the thyroid.

Our findings revealed a significant reduction in these antibody levels among patients who received vitamin D3, showcasing a 30.5% decrease compared to just a 16.5% decrease in the placebo group. This suggests that vitamin D3 supplementation may play a beneficial role in managing the autoimmune activity associated with hypothyroidism.

Overall, our research shows that addressing vitamin D deficiency might be an effective strategy to help manage Hashimoto's thyroiditis, which could encourage discussion about incorporating vitamin D as part of treatment plans for patients. Further research will be necessary to confirm these findings and explore the long-term benefits of vitamin D supplementation.
Read More
9
Vitamin D3 and iodine benefits
We investigated the potential benefits of vitamin D3 in treating hypothyroidism caused by high iodide intake in a study involving pregnant rats. The study involved adjusting iodide intake and supplementing with 1,25-dihydroxy-vitamin D (the active form of vitamin D) to see if these interventions could positively impact thyroid function and related complications.

The newborn rats were exposed to high levels of iodide initially, leading to thyroid dysfunction. After some weeks, we provided either iodide adjustment, vitamin D3 supplementation, or both to assess their effects.

Surprisingly, while vitamin D3 was combined with iodide adjustment, the study did not isolate the effect of vitamin D3 alone. However, we observed that both interventions increased levels of beneficial fatty acids, which are linked to improved thyroid function and lessened cholesterol issues in these rats.

These results suggest that implementing a proper iodide intake and vitamin D3 supplementation can improve thyroid health but do not clearly define vitamin D3's individual impact without additional research isolating its effects.
Read More
8
Vitamin D3 improves thyroid function
We evaluated the effects of vitamin D3 supplementation on hypothyroidism, specifically in patients with Hashimoto's thyroiditis (HT). Our analysis involved 12 randomized controlled trials, comparing the outcomes of individuals receiving vitamin D3 against those given a placebo or no treatment at all.

Through this thorough examination, we found that vitamin D3 did promote significant improvements in thyroid function and immune response. Specifically, we observed a reduction in two key antibodies: anti-thyroid peroxidase (TPO-Ab) and thyroglobulin antibody (TG-Ab). These reductions suggest a positive effect on the autoimmune process involved in Hashimoto's thyroiditis.

Additionally, we noted improvements in thyroid hormone levels, including free thyroxine (FT4) and free triiodothyronine (FT3), while thyroid-stimulating hormone (TSH) levels showed a decrease. These findings indicate that vitamin D3 supplementation may benefit thyroid health and help manage hypothyroidism more effectively.

For those considering vitamin D3 as a treatment option, particularly those who have been on vitamin D for longer than 12 weeks, the results suggest a more pronounced effect on improving antibody levels and thyroid function. Thus, there appears to be a compelling case for vitamin D3 as a supportive treatment in managing Hashimoto's thyroiditis and related hypothyroidism.
Read More
We evaluated the potential impact of vitamin D3 treatment on patients suffering from Hashimoto's thyroiditis, particularly looking at its effect on the development of hypothyroidism. Our investigation included 75 individuals diagnosed with this autoimmune disorder and a control group of 43 healthy participants. The results showed that patients with Hashimoto's thyroiditis had notably lower vitamin D levels compared to those without the condition.

To address vitamin D deficiency, we administered a weekly dose of 50,000 units of vitamin D3 to those who were lacking it for eight weeks. After this treatment, we observed significant improvements. Thyroid autoantibodies, which indicate inflammation and damage in the thyroid, decreased in those who were treated. Additionally, we found that levels of HDL cholesterol improved, suggesting potential benefits for cardiovascular health.

Our findings point toward vitamin D deficiency being common among those with Hashimoto's thyroiditis. By addressing this deficiency, we may slow down the progression toward hypothyroidism and reduce cardiovascular risks associated with the condition. Therefore, monitoring and supplementing vitamin D could play a crucial role in managing the health of these patients effectively.
Read More
We set out to understand the relationship between vitamin D3 levels and hypothyroid Hashimoto's thyroiditis (HT), a common autoimmune condition. During our investigation, we enrolled 86 participants, dividing them into two groups: 41 patients suffering from hypothyroid HT and 45 healthy individuals with normal thyroid function.

Our findings revealed an interesting trend. We observed that lower serum levels of 25-hydroxyvitamin D (25OHD) were significantly associated with HT. Specifically, for every increase of 5 ng/ml in 25OHD, the odds of developing HT decreased by approximately 19%. This pattern persisted even after we factored in variables such as age, gender, and body mass index (BMI).

Overall, higher levels of vitamin D3 appear to correlate with a reduced risk of HT. This suggests that maintaining adequate vitamin D3 levels could play a beneficial role in preventing or managing this autoimmune condition. However, while our study shows a clear association, it does not isolate the effects of vitamin D3 from other factors that may also influence thyroid health.
Read More

User Reviews

USERS' SCORE
Good
Based on 3 Reviews
8.4
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Reduced muscle cramps
Calcium citrate has become an essential part of my routine and began working in just ten days. I take 6 tablets daily, along with alfacalcidol to enhance calcium absorption. The quality is excellent for a reasonable price. Following surgery for hypothyroidism and hypoparathyroidism, I noticed improved nerve conduction, and muscle twitching and cramps have ceased. This formulation has been suitable for me.
Read More
7.5
Hair growth improvement
2 people found this helpful
I received my doctor’s approval to take calcium for a couple of months. I am pleased with the noticeable growth of new hair and a reduction in hair loss. My nails began to improve in just a few weeks. My analysis results are within normal limits. Calcium is particularly necessary for those with hypothyroidism.
Read More
7.5
No side effects
My endocrinologist advised me to take calcium due to my hypothyroidism, alongside an artificial hormone. I find the calcium beneficial and experienced no side effects from its use.
Read More

Frequently Asked Questions

9
Reduced muscle cramps
Calcium citrate has become an essential part of my routine and began working in just ten days. I take 6 tablets daily, along with alfacalcidol to enhance calcium absorption. The quality is excellent for a reasonable price. Following surgery for hypothyroidism and hypoparathyroidism, I noticed improved nerve conduction, and muscle twitching and cramps have ceased. This formulation has been suitable for me.
7.5
Hair growth improvement
2 people found this helpful
I received my doctor’s approval to take calcium for a couple of months. I am pleased with the noticeable growth of new hair and a reduction in hair loss. My nails began to improve in just a few weeks. My analysis results are within normal limits. Calcium is particularly necessary for those with hypothyroidism.
7.5
No side effects
My endocrinologist advised me to take calcium due to my hypothyroidism, alongside an artificial hormone. I find the calcium beneficial and experienced no side effects from its use.
8
Vitamin D3 improves thyroid function
We evaluated the effects of vitamin D3 supplementation on hypothyroidism, specifically in patients with Hashimoto's thyroiditis (HT). Our analysis involved 12 randomized controlled trials, comparing the outcomes of individuals receiving vitamin D3 against those given a placebo or no treatment at all.

Through this thorough examination, we found that vitamin D3 did promote significant improvements in thyroid function and immune response. Specifically, we observed a reduction in two key antibodies: anti-thyroid peroxidase (TPO-Ab) and thyroglobulin antibody (TG-Ab). These reductions suggest a positive effect on the autoimmune process involved in Hashimoto's thyroiditis.

Additionally, we noted improvements in thyroid hormone levels, including free thyroxine (FT4) and free triiodothyronine (FT3), while thyroid-stimulating hormone (TSH) levels showed a decrease. These findings indicate that vitamin D3 supplementation may benefit thyroid health and help manage hypothyroidism more effectively.

For those considering vitamin D3 as a treatment option, particularly those who have been on vitamin D for longer than 12 weeks, the results suggest a more pronounced effect on improving antibody levels and thyroid function. Thus, there appears to be a compelling case for vitamin D3 as a supportive treatment in managing Hashimoto's thyroiditis and related hypothyroidism.
We explored the relationship between vitamin D supplementation and hypothyroidism through the D-Health Trial, a well-structured study involving over 21,000 Australian participants aged 60 and older. This trial randomly assigned participants to receive either a monthly dose of 60,000 international units of vitamin D or a placebo, allowing us to effectively assess any potential benefits of vitamin D on thyroid function.

Our analysis revealed that, during an average follow-up of 4.1 years, 293 participants developed hypothyroidism. Interestingly, the rates were similar between the groups, with 1.5% of those taking vitamin D and 1.7% of those on placebo developing the condition. Overall, vitamin D supplementation did not significantly lower the risk of hypothyroidism, as shown by the hazard ratio of 0.89.

However, we did notice a slight difference when analyzing the data by gender. While there was some evidence suggesting a potential benefit for females (with a hazard ratio of 0.78), no such effect was observed in males. Given the findings, it seems that vitamin D supplementation does not provide a clear protective effect against hypothyroidism overall, although the intriguing trend observed in females deserves further research to better understand its implications.
We explored the relationship between vitamin D levels, vitamin D receptor polymorphisms, and hypothyroidism in a group of Egyptian patients. This involved comparing 35 hypothyroid patients to 35 healthy individuals to understand if vitamin D plays a significant role in managing hypothyroidism.

The findings highlighted that patients with hypothyroidism had notably lower vitamin D levels compared to the healthy control group. We observed an inverse relationship between vitamin D levels and markers such as TSH, HOMA-IR, and thyroid autoantibodies (anti-TG and anti-TPO). However, when it came to vitamin D receptor polymorphisms (specifically Fok1 and Apa1), the study revealed no significant connection with TSH or vitamin D levels in either group.

While the study confirmed an association between low vitamin D and features of hypothyroidism, such as increased thyroid gland volume, nodularity, and vascularity, it did not establish that vitamin D treatment directly improves hypothyroidism symptoms. Therefore, we conclude that although vitamin D deficiency may be linked to thyroid dysfunction, the specific therapeutic effects of vitamin D3 on hypothyroidism remain unproven.
We set out to understand the relationship between vitamin D3 levels and hypothyroid Hashimoto's thyroiditis (HT), a common autoimmune condition. During our investigation, we enrolled 86 participants, dividing them into two groups: 41 patients suffering from hypothyroid HT and 45 healthy individuals with normal thyroid function.

Our findings revealed an interesting trend. We observed that lower serum levels of 25-hydroxyvitamin D (25OHD) were significantly associated with HT. Specifically, for every increase of 5 ng/ml in 25OHD, the odds of developing HT decreased by approximately 19%. This pattern persisted even after we factored in variables such as age, gender, and body mass index (BMI).

Overall, higher levels of vitamin D3 appear to correlate with a reduced risk of HT. This suggests that maintaining adequate vitamin D3 levels could play a beneficial role in preventing or managing this autoimmune condition. However, while our study shows a clear association, it does not isolate the effects of vitamin D3 from other factors that may also influence thyroid health.

References

  1. Tang J, Shan S, Li F, Yun P. Effects of vitamin D supplementation on autoantibodies and thyroid function in patients with Hashimoto's thyroiditis: A systematic review and meta-analysis. Medicine (Baltimore). 2023;102:e36759. 10.1097/MD.0000000000036759
  2. Waterhouse M, Pham H, Rahman ST, Baxter C, Duarte Romero B, et al. The Effect of Vitamin D Supplementation on Hypothyroidism in the Randomized Controlled D-Health Trial. Thyroid. 2023;33:1302. 10.1089/thy.2023.0317
  3. Bhakat B, Pal J, Das S, Charaborty SK, SircarMedical NR. A Prospective Study to Evaluate the Possible Role of Cholecalciferol Supplementation on Autoimmunity in Hashimoto's Thyroiditis. J Assoc Physicians India. 2023;71:1.
  4. Liu Q, Zhang Y, Zhao H, Yao X. Increased Epoxyeicosatrienoic Acids and Hydroxyeicosatetraenoic Acids After Treatment of Iodide Intake Adjustment and 1,25-Dihydroxy-Vitamin D Supplementation in High Iodide Intake-Induced Hypothyroid Offspring Rats. Front Physiol. 2021;12:669652. 10.3389/fphys.2021.669652
  5. ElRawi HA, Ghanem NS, ElSayed NM, Ali HM, Rashed LA, et al. Study of Vitamin D Level and Vitamin D Receptor Polymorphism in Hypothyroid Egyptian Patients. J Thyroid Res. 2019;2019:3583250. 10.1155/2019/3583250
  6. Ucan B, Sahin M, Sayki Arslan M, Colak Bozkurt N, Kizilgul M, et al. Vitamin D Treatment in Patients with Hashimoto's Thyroiditis may Decrease the Development of Hypothyroidism. Int J Vitam Nutr Res. 2016;86:9. 10.1024/0300-9831/a000269
  7. Anaraki PV, Aminorroaya A, Amini M, Feizi A, Iraj B, et al. Effects of Vitamin D deficiency treatment on metabolic markers in Hashimoto thyroiditis patients. J Res Med Sci. 2017;22:5. 10.4103/1735-1995.199090
  8. Mansournia N, Mansournia MA, Saeedi S, Dehghan J. The association between serum 25OHD levels and hypothyroid Hashimoto's thyroiditis. J Endocrinol Invest. 2014;37:473. 10.1007/s40618-014-0064-y
  9. Kemmochi S, Fujimoto H, Woo GH, Hirose M, Nishikawa A, et al. Preventive effects of calcitriol on the development of capsular invasive carcinomas in a rat two-stage thyroid carcinogenesis model. J Vet Med Sci. 2011;73:655.
  10. Borzuei S, Amjad SV, Badiei M, Farmany A, Cheraghi Z. Investigating salivary concentration of calcium ion in hypothyroidism. Health Sci Rep. 2023;6:e1669. 10.1002/hsr2.1669
  11. Salhi S, Oueslati I, Ayari S, Kamoun E, Yazidi M, et al. A case of reversible hypoparathyroidism in a patient with Riedel's thyroiditis treated with glucocorticoids. Clin Case Rep. 2023;11:e7085. 10.1002/ccr3.7085
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