5/4/2025
Last update
5/4/2025
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 36 Researches
7.8
USERS' SCORE
Moderately Good
Based on 51 Reviews
7.7
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol)
13 mcg (500 IU)
63%
Calcium (as Calcium Citrate)
630 mg
48%
Top Medical Research Studies
9
We examined a collection of randomized controlled trials to determine the impact of calcium plus vitamin D supplementation on fracture prevention.
The results revealed a promising 15% reduction in total fractures and a remarkable 30% drop in hip fractures among those taking these supplements.
This convincing evidence supports the recommendation of calcium and vitamin D for reducing fracture risk, especially in older adults, whether living at home or in care facilities.
The results revealed a promising 15% reduction in total fractures and a remarkable 30% drop in hip fractures among those taking these supplements.
This convincing evidence supports the recommendation of calcium and vitamin D for reducing fracture risk, especially in older adults, whether living at home or in care facilities.
Read More
9
We explored how the combination of calcium, vitamin D, and zinc impacts osteoporosis in ovariectomized rats. Using a well-structured study design, we divided 49 rats into various groups to compare results against a control.
Our findings suggest that this combined supplement helps enhance calcium absorption and reduces bone deterioration by lowering specific osteoporosis-related factors. This could point toward a potential alternative treatment for postmenopausal osteoporosis, though further research in humans is necessary.
Our findings suggest that this combined supplement helps enhance calcium absorption and reduces bone deterioration by lowering specific osteoporosis-related factors. This could point toward a potential alternative treatment for postmenopausal osteoporosis, though further research in humans is necessary.
Read More
9
Vitamin D derivatives enhance bone health
We looked into the potential effects of vitamin D3, particularly its derivatives, on osteoporosis. Recent research highlights how modifications to the A-ring of 1α,25-dihydroxyvitamin D can enhance its binding to the vitamin D receptor. This change not only boosts the vitamin's effectiveness but also helps it resist breakdown in the body, making it stay active for longer periods.
One standout example is a derivative known as AH-1, which demonstrated significant benefits for bone health in an osteoporosis model using ovariectomized rats. When given at a low dosage, AH-1 outperformed natural vitamin D, suggesting a promising path for improving osteoporosis treatment.
We also noted that while traditional vitamin D has its benefits, these newly developed analogs could lead to treatments that target osteoporosis more effectively, providing options without the side effects commonly associated with vitamin D therapy. This research emphasizes the importance of vitamin D derivatives as we seek better solutions for managing bone health.
One standout example is a derivative known as AH-1, which demonstrated significant benefits for bone health in an osteoporosis model using ovariectomized rats. When given at a low dosage, AH-1 outperformed natural vitamin D, suggesting a promising path for improving osteoporosis treatment.
We also noted that while traditional vitamin D has its benefits, these newly developed analogs could lead to treatments that target osteoporosis more effectively, providing options without the side effects commonly associated with vitamin D therapy. This research emphasizes the importance of vitamin D derivatives as we seek better solutions for managing bone health.
Read More
Most Useful Reviews
10
Essential for women
34 people found this helpful
Calcium citrate with vitamin D3 is a true find. It absorbs completely and is vital for women to prevent osteoporosis while improving hair, nails, and teeth health.
Read More
9
Highly recommended calcium
5 people found this helpful
I buy this calcium for my mother with osteoporosis. Unlike the previous calcium-D3 she took, which contained non-effective calcium carbonate, this one is very effective thanks to its citrate form. It’s recognised for better absorption, and I recommend it to anyone needing calcium.
Read More
9
Convenient supplementation
3 people found this helpful
My mother broke her ribs due to osteoporosis, so I bought this calcium supplement. The added vitamin D3 promotes calcium absorption, and it’s been helpful. She’s already on her second purchase, showing its effectiveness in her daily regime.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 36 Researches
7.8
- All Researches
9.5
We looked into the effects of vitamin D3 on osteoporosis management, particularly in relation to glucocorticoid-induced complications. In a recent case involving an 85-year-old patient with IgG4-related disease, vitamin D3 was used alongside prednisone and azathioprine. The goal was to prevent bone density loss often seen with steroid treatments.
Our focus on this case revealed that vitamin D3 played an essential role in supporting the patient’s bone health. This addition helped mitigate some side effects of long-term steroid use, specifically protecting against osteoporosis, while the patient experienced significant improvements in their orbital symptoms.
Over the course of treatment, the patient showed remarkable recovery in just 24 hours, along with a complete resolution of issues related to their eye condition over the following year. While direct data on vitamin D3's standalone effectiveness isn't highlighted, its use in this context underscores a possible beneficial role in osteoporosis prevention when combined with corticosteroids.
Our focus on this case revealed that vitamin D3 played an essential role in supporting the patient’s bone health. This addition helped mitigate some side effects of long-term steroid use, specifically protecting against osteoporosis, while the patient experienced significant improvements in their orbital symptoms.
Over the course of treatment, the patient showed remarkable recovery in just 24 hours, along with a complete resolution of issues related to their eye condition over the following year. While direct data on vitamin D3's standalone effectiveness isn't highlighted, its use in this context underscores a possible beneficial role in osteoporosis prevention when combined with corticosteroids.
Read More
9
We explored how the combination of calcium, vitamin D, and zinc impacts osteoporosis in ovariectomized rats. Using a well-structured study design, we divided 49 rats into various groups to compare results against a control.
Our findings suggest that this combined supplement helps enhance calcium absorption and reduces bone deterioration by lowering specific osteoporosis-related factors. This could point toward a potential alternative treatment for postmenopausal osteoporosis, though further research in humans is necessary.
Our findings suggest that this combined supplement helps enhance calcium absorption and reduces bone deterioration by lowering specific osteoporosis-related factors. This could point toward a potential alternative treatment for postmenopausal osteoporosis, though further research in humans is necessary.
Read More
9
We examined the effects of teriparatide combined with calcium and vitamin D versus standard calcium and vitamin D treatment on bone health in premenopausal women with pregnancy- and lactation-associated osteoporosis.
In our study, 19 women received teriparatide, while 8 only received calcium and vitamin D over 24 months. Results showed that those treated with teriparatide experienced significantly greater increases in bone mineral density at the lumbar spine after 12 and 24 months, indicating better bone health outcomes.
Overall, we found that teriparatide treatment substantially benefits women facing this rare condition.
In our study, 19 women received teriparatide, while 8 only received calcium and vitamin D over 24 months. Results showed that those treated with teriparatide experienced significantly greater increases in bone mineral density at the lumbar spine after 12 and 24 months, indicating better bone health outcomes.
Overall, we found that teriparatide treatment substantially benefits women facing this rare condition.
Read More
9
We focused on the potential of nanoscale calcium salt formulations combined with vitamin D and natural minerals to treat osteoporosis. In our study, these innovative formulations showed promising results by enhancing bone density and reducing bone resorption in osteoporotic rats.
The tablets increased osteoblast activity and decreased osteoclast activity without causing toxicity. This dual action positions these calcium salt nanocomposites as a novel approach in osteoporosis management, offering a safer alternative to traditional treatments.
The tablets increased osteoblast activity and decreased osteoclast activity without causing toxicity. This dual action positions these calcium salt nanocomposites as a novel approach in osteoporosis management, offering a safer alternative to traditional treatments.
Read More
9
We explored how adding vitamin D and calcium to denosumab therapy impacts bone health in patients with primary osteoporosis over four years.
The study involved two groups: one receiving just denosumab and another receiving denosumab with vitamin D and calcium.
Both groups saw improvements in bone health, but the combination group showed significant gains in hip bone density at 12 months and lumbar bone density from 24 to 48 months.
This suggests that ongoing vitamin D and calcium supplementation is beneficial alongside denosumab treatment.
The study involved two groups: one receiving just denosumab and another receiving denosumab with vitamin D and calcium.
Both groups saw improvements in bone health, but the combination group showed significant gains in hip bone density at 12 months and lumbar bone density from 24 to 48 months.
This suggests that ongoing vitamin D and calcium supplementation is beneficial alongside denosumab treatment.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 51 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
10
Essential for women
34 people found this helpful
Calcium citrate with vitamin D3 is a true find. It absorbs completely and is vital for women to prevent osteoporosis while improving hair, nails, and teeth health.
Read More
9
Highly recommended calcium
5 people found this helpful
I buy this calcium for my mother with osteoporosis. Unlike the previous calcium-D3 she took, which contained non-effective calcium carbonate, this one is very effective thanks to its citrate form. It’s recognised for better absorption, and I recommend it to anyone needing calcium.
Read More
9
Convenient supplementation
3 people found this helpful
My mother broke her ribs due to osteoporosis, so I bought this calcium supplement. The added vitamin D3 promotes calcium absorption, and it’s been helpful. She’s already on her second purchase, showing its effectiveness in her daily regime.
Read More
9
Energy and vitality boost
3 people found this helpful
This supplement improved my nails, hair, immunity and mood, giving me a surge of energy. I recommend it for treating osteoporosis as it strengthens bones and supports overall health with calcium and vitamin D3.
Read More
0
Ineffective composition
3 people found this helpful
I bought this calcium for my mother with osteoporosis. Although marketed as better absorbed, the additives are concerning. After six months of use, there were no improvements in her tests, leading me to advise against it.
Read More
Frequently Asked Questions
7.5
Joint improvements
7 people found this helpful
After surgery, I realised I needed calcium due to issues linked to osteoporosis. Calcium citrate is easy to take and has no side effects. After a week, I noticed my knees stopped crunching, and my nails became healthier.
8.5
Improved test results
8 people found this helpful
I bought calcium citrate for a young girl with osteoporosis. After a couple of months, her test results surprised her doctors. I highly recommend this supplement.
0
Ineffective composition
3 people found this helpful
I bought this calcium for my mother with osteoporosis. Although marketed as better absorbed, the additives are concerning. After six months of use, there were no improvements in her tests, leading me to advise against it.
9
Condition improvement
2 people found this helpful
I bought this for my mother with osteoporosis, and her condition has improved significantly. The doctor was surprised by the results! This supplement has proven effective for her.
7.5
Thicker nails
2 people found this helpful
I found this vitamin effective after just two weeks; my nails have stopped crumbling and have become thicker and shinier. I also purchased it for my parents to help prevent osteoporosis.
8
Pain relief achieved
1 people found this helpful
My mother has osteoporosis, and her doctor prescribed calcium with vitamin D3. This calcium is convenient as it includes D3. One tablet a day suffices. We take it alongside Glucosamine and Chondroitin. The result is effective, as the leg pain has stopped bothering her, and the price is quite reasonable.
9
Energy and vitality boost
3 people found this helpful
This supplement improved my nails, hair, immunity and mood, giving me a surge of energy. I recommend it for treating osteoporosis as it strengthens bones and supports overall health with calcium and vitamin D3.
9
We examined a collection of randomized controlled trials to determine the impact of calcium plus vitamin D supplementation on fracture prevention.
The results revealed a promising 15% reduction in total fractures and a remarkable 30% drop in hip fractures among those taking these supplements.
This convincing evidence supports the recommendation of calcium and vitamin D for reducing fracture risk, especially in older adults, whether living at home or in care facilities.
The results revealed a promising 15% reduction in total fractures and a remarkable 30% drop in hip fractures among those taking these supplements.
This convincing evidence supports the recommendation of calcium and vitamin D for reducing fracture risk, especially in older adults, whether living at home or in care facilities.
9
We explored how adding vitamin D and calcium to denosumab therapy impacts bone health in patients with primary osteoporosis over four years.
The study involved two groups: one receiving just denosumab and another receiving denosumab with vitamin D and calcium.
Both groups saw improvements in bone health, but the combination group showed significant gains in hip bone density at 12 months and lumbar bone density from 24 to 48 months.
This suggests that ongoing vitamin D and calcium supplementation is beneficial alongside denosumab treatment.
The study involved two groups: one receiving just denosumab and another receiving denosumab with vitamin D and calcium.
Both groups saw improvements in bone health, but the combination group showed significant gains in hip bone density at 12 months and lumbar bone density from 24 to 48 months.
This suggests that ongoing vitamin D and calcium supplementation is beneficial alongside denosumab treatment.
8
We investigated a two-year treatment of risedronate combined with calcium and vitamin D in osteoporosis patients who also had esophageal varices and cirrhosis. By splitting the participants into two groups, we found that those treated with risedronate showed a significant increase in lumbar spine bone mineral density. Importantly, there were no gastrointestinal bleeding incidents, suggesting safety for this vulnerable population. While some risks for esophagitis increased, the benefits in bone health were notable for the risedronate group compared to the control group.
2
We aimed to find out if calcium and vitamin D supplementation can improve bone mineral density (BMD) in healthy premenopausal women. After reviewing seven randomized controlled trials with nearly 1,000 participants, we found no significant improvements in total hip or lumbar spine BMD compared to placebo.
Our evidence indicates that neither calcium nor vitamin D—alone or combined—showed benefits for increasing bone strength or preventing fractures in this group. This suggests that there is little support for recommending these supplements to enhance bone health in healthy premenopausal women.
Our evidence indicates that neither calcium nor vitamin D—alone or combined—showed benefits for increasing bone strength or preventing fractures in this group. This suggests that there is little support for recommending these supplements to enhance bone health in healthy premenopausal women.
9
We explored how the combination of calcium, vitamin D, and zinc impacts osteoporosis in ovariectomized rats. Using a well-structured study design, we divided 49 rats into various groups to compare results against a control.
Our findings suggest that this combined supplement helps enhance calcium absorption and reduces bone deterioration by lowering specific osteoporosis-related factors. This could point toward a potential alternative treatment for postmenopausal osteoporosis, though further research in humans is necessary.
Our findings suggest that this combined supplement helps enhance calcium absorption and reduces bone deterioration by lowering specific osteoporosis-related factors. This could point toward a potential alternative treatment for postmenopausal osteoporosis, though further research in humans is necessary.
References
- Liu S, Li J, Zhang M. Determination of immune factor levels in serum and local hematoma samples of osteoporotic fracture patients and clinical study of the effect of active vitamin D3 treatment on immune factor levels. J Orthop Surg Res. 2023;18:291. 10.1186/s13018-023-03777-7
- Wang S, Luo Z, Luo H, Li Z, Yuan Z, et al. Effects of a calcium/vitamin D/Zinc combination on anti-osteoporosis in ovariectomized rats. J Trace Elem Med Biol. 2023;77:127138. 10.1016/j.jtemb.2023.127138
- Méndez-Sánchez L, Clark P, Winzenberg TM, Tugwell P, Correa-Burrows P, et al. Calcium and vitamin D for increasing bone mineral density in premenopausal women. Cochrane Database Syst Rev. 2023;1:CD012664. 10.1002/14651858.CD012664.pub2
- Santos LAA, Lima TB, de Carvalho Nunes HR, Qi X, Romeiro FG. Two-year risedronate treatment for osteoporosis in patients with esophageal varices: a non-randomized clinical trial. Hepatol Int. 2022;16:1458. 10.1007/s12072-022-10366-z
- Lampropoulou-Adamidou K, Trovas G, Triantafyllopoulos IK, Yavropoulou MP, Anastasilakis AD, et al. Teriparatide Treatment in Patients with Pregnancy- and Lactation-Associated Osteoporosis. Calcif Tissue Int. 2021;109:554. 10.1007/s00223-021-00871-y
- Dashnyam K, Bayaraa O, Mandakhbayar N, Park JH, Lee JH, et al. Nanoscale Calcium Salt-Based Formulations As Potential Therapeutics for Osteoporosis. ACS Biomater Sci Eng. 2020;6:4604. 10.1021/acsbiomaterials.0c00219
- Li S, Xi C, Li L, Long Z, Zhang N, et al. Comparisons of different vitamin D supplementation for prevention of osteoporotic fractures: a Bayesian network meta-analysis and meta-regression of randomised controlled trials. Int J Food Sci Nutr. 2021;72:518. 10.1080/09637486.2020.1830264
- Suzuki T, Nakamura Y, Kato H. Vitamin D and Calcium Addition during Denosumab Therapy over a Period of Four Years Significantly Improves Lumbar Bone Mineral Density in Japanese Osteoporosis Patients. Nutrients. 2018;10. 10.3390/nu10030272
- García-Gomáriz C, Blasco JM, Macián-Romero C, Guillem-Hernández E, Igual-Camacho C. Effect of 2 years of endurance and high-impact training on preventing osteoporosis in postmenopausal women: randomized clinical trial. Menopause. 2018;25:301. 10.1097/GME.0000000000001005
- Nakamura Y, Suzuki T, Yoshida T, Yamazaki H, Kato H. Vitamin D and Calcium Are Required during Denosumab Treatment in Osteoporosis with Rheumatoid Arthritis. Nutrients. 2017;9. 10.3390/nu9050428
- Brech GC, Ciolac EG, Peterson MD, Greve JM. Serum 25-hydroxyvitamin D levels are associated with functional capacity but not with postural balance in osteoporotic postmenopausal women. Clinics (Sao Paulo). 2017;72:11. 10.6061/clinics/2017(01)03
- Florenzano P, Mezzano V, Le-Bert M, González G. [Bone involvement in systemic mastocytosis: Report of two cases]. Rev Med Chil. 2016;144:401. 10.4067/S0034-98872016000300018
- Safer U, Safer VB, Demir SO, Yanikoglu I. Effects of Bisphosphonates and Calcium plus Vitamin-D Supplements on Cognitive Function in Postmenopausal Osteoporosis§. Endocr Metab Immune Disord Drug Targets. 2016;16:56.
- Weaver CM, Alexander DD, Boushey CJ, Dawson-Hughes B, Lappe JM, et al. Calcium plus vitamin D supplementation and risk of fractures: an updated meta-analysis from the National Osteoporosis Foundation. Osteoporos Int. 2016;27:367. 10.1007/s00198-015-3386-5
- Chen Y, Wan JX, Jiang DW, Fu BB, Cui J, et al. Efficacy of calcitriol in treating glucocorticoidinduced osteoporosis in patients with nephrotic syndrome: an open-label, randomized controlled study. Clin Nephrol. 2015;84:262. 10.5414/CN108473
- Overton ET, Chan ES, Brown TT, Tebas P, McComsey GA, et al. Vitamin D and Calcium Attenuate Bone Loss With Antiretroviral Therapy Initiation: A Randomized Trial. Ann Intern Med. 2015;162:815. 10.7326/M14-1409
- Mendoza-Vargas LÁ, Sevilla-Fuentes S, Bautista-Becerril B, Berthaúd-González B, Falfán-Valencia R, et al. IgG4-RD-Associated Mikulicz Syndrome Without Classic Systemic Involvement-A Case Report. J Clin Med. 2025;14. 10.3390/jcm14030958
- Yang C, Chen L, Guo X, Sun H, Miao D. The Vitamin D-Sirt1/PGC1α Axis Regulates Bone Metabolism and Counteracts Osteoporosis. J Orthop Translat. 2025;50:211. 10.1016/j.jot.2024.10.011
- Paul T, Garg B, Kapoor N, Patil V, Kachnerkar N, et al. A Prospective, Active-controlled, Randomized, Double-blind, Multicenter, Phase III Study to Compare the Safety and Efficacy of Biosimilar Denosumab vs Reference Denosumab in the Treatment of Postmenopausal Osteoporosis. J Assoc Physicians India. 2025;73:e8. 10.59556/japi.73.0772
- Sawant D, Kamble N. Overcoming Recurrent Isolated Sleep Paralysis: A Case Report of Integrative Management With Yoga, Meditation, and Vitamin D3 Supplementation. Cureus. 2024;16:e76626. 10.7759/cureus.76626
- Kittaka A. Synthetic Studies on Vitamin D Derivatives with Diverse but Selective Biological Activities. Chem Pharm Bull (Tokyo). 2025;73:1. 10.1248/cpb.c24-00598
- Elmalah SG, Mohsen ROM, Hassan R. Selenium nano particles versus nano vitamin D3 in modulating anastrozole-induced osteoporosis on the mandibular alveolar bone of albino rats. J Stomatol Oral Maxillofac Surg. 2024. 10.1016/j.jormas.2024.102181
- Chang CH, Yang SJ, Young TH, Yao WC. Effect of co-loaded vitamin D3 on intravenous injectable raloxifene delivery system. Colloids Surf B Biointerfaces. 2025;246:114379. 10.1016/j.colsurfb.2024.114379
- Kluijver LG, Wagenmakers MAEM, Wilson JHP, Langendonk JG. The impact of minimal sunlight exposure on bone health: insights from a cohort study in erythropoietic protoporphyria. J Clin Endocrinol Metab. 2024. 10.1210/clinem/dgae729
- Chen Y, Qiu H, Xuan L, Jin Y, Chen R, et al. Acupuncture in Treating Osteopenia: A Multicenter, Randomized, Controlled Clinical Trial. Complement Med Res. 2024;31:516. 10.1159/000541440
- Moon RJ, D' Angelo S, Curtis EM, Ward KA, Crozier SR, et al. Pregnancy vitamin D supplementation and offspring bone mineral density in childhood follow-up of a randomized controlled trial. Am J Clin Nutr. 2024;120:1134. 10.1016/j.ajcnut.2024.09.014
- Pinto-Bonilla R, Baeza-Noci J, Blanco CC, Gumbau GJV, Fernández RJ, et al. Real-world effectiveness and safety of combined calcium 600 mg and cholecalciferol 2000 IU for treating vitamin d deficiency: Results from a nationwide study with focus in osteoporosis. Bone Rep. 2024;22:101796. 10.1016/j.bonr.2024.101796
- Xu D, Liu J, Zhang D, Zhang X, Huang C, et al. [Effects of thunder-fire moxibustion on balance function and musculoskeletal metabolism in female patients of primary osteoporosis with low muscle mass]. Zhongguo Zhen Jiu. 2024;44:859. 10.13703/j.0255-2930.20231229-0002
- Shin S, Hong N, Rhee Y. A randomized controlled trial of the effect of raloxifene plus cholecalciferol versus cholecalciferol alone on bone mineral density in postmenopausal women with osteopenia. JBMR Plus. 2024;8:ziae073. 10.1093/jbmrpl/ziae073
- Wu T, Lin Z, Wang C, Liu X. Correlation between vitamin D levels and blood pressure in elderly hypertensive patients with osteoporosis. Front Med (Lausanne). 2024;11:1396254. 10.3389/fmed.2024.1396254
- Wang JC, Chung SM, Wu PT, Tu YK, Lai PC, et al. Optimizing bone health in people living with HIV: insights from a network meta-analysis of randomized controlled trials. EClinicalMedicine. 2025;81:103103. 10.1016/j.eclinm.2025.103103
- Chen L, Lin S, He X, Ye J, Huang Y, et al. A calcium-loaded complex based on Antarctic krill protein and supplemented with pectin promotes calcium absorption and bone health. Int J Biol Macromol. 2025. 10.1016/j.ijbiomac.2025.141634
- Ma R, Romano E, Ashworth M, Vancampfort D, Solmi M, et al. Is there a disparity in osteoporosis referral and treatment among people with affective disorders? A ten-year data linkage study. Gen Hosp Psychiatry. 2025;94:56. 10.1016/j.genhosppsych.2025.02.009
- Chen J, Wang J, Jia W, Zhang Y, Li H, et al. Effect of salmon calcitonin combined with calcium antagonist on blood calcium and phosphorus ion concentration in osteoporosis rats. Eur J Med Res. 2025;30:115. 10.1186/s40001-025-02384-y
- Shi L, Bao Y, Deng X, Xu X, Hu J. Association between calcium and vitamin D supplementation and increased risk of kidney stone formation in patients with osteoporosis in Southwest China: a cross-sectional study. BMJ Open. 2025;15:e092901. 10.1136/bmjopen-2024-092901
- Joris V, Balmayor ER, van Griensven M. miR-125b differentially impacts mineralization in dexamethasone and calcium-treated human mesenchymal stem cells. Mol Ther Nucleic Acids. 2025;36:102446. 10.1016/j.omtn.2024.102446
