' 
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7
USERS' SCORE
Good
Based on 12 Reviews
8.7
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol)
20 mcg(800 IU)
100%
Calcium (as Calcium Carbonate)
600 mg
46%
Magnesium (as Magnesium Oxide)
50 mg
12%
Zinc (as Zinc Oxide)
7.5 mg
68%
Copper (as Copper Oxide)
1 mg
111%
Manganese (as Manganese Sulfate)
1.8 mg
78%
Boron (as Sodium Borate)
250 mcg
**
Top Medical Research Studies
9
Calcium complex enhances bone health
A calcium-loaded complex based on Antarctic krill protein and supplemented with pectin promotes calcium absorption and bone health.
Study shows complex enhances calcium
Our research explored the effects of a new calcium-loaded complex, made from Antarctic krill protein and enriched with pectin, on calcium absorption and bone health in mice with calcium deficiency. We created a model that simulated calcium deficiency, which is a significant concern as it can contribute to osteoporosis.
We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.
Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health.
We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.
Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health.
Read More
8
Calcium's role in osteoporosis explored
Is there a disparity in osteoporosis referral and treatment among people with affective disorders? A ten-year data linkage study.
Moderate relevance due to focus
We sought to understand whether individuals with affective disorders (AD) receive different levels of osteoporosis treatment compared to those without these mental health conditions. To do this, we analyzed a large group of people over a ten-year period, looking at how often patients with AD received calcium prescriptions and referrals for osteoporosis screening.
Our findings show that people with AD were more likely to receive calcium treatments, including calcium alone and calcium combined with vitamin D, compared to healthy controls. Specifically, the study highlighted that individuals with AD had a 64% higher chance of receiving a calcium prescription and a 125% higher likelihood of being referred for screening within two years of their diagnosis.
Despite these increased rates of screening and treatment, there remains a question about whether such efforts are effectively reducing the risk of osteoporosis and fractures in this vulnerable group. Factors such as age, sex, ethnic background, and use of analgesics also played significant roles in the treatment pathways for these patients, indicating that while there are advancements in management, the overall effectiveness still requires further investigation.
Our findings show that people with AD were more likely to receive calcium treatments, including calcium alone and calcium combined with vitamin D, compared to healthy controls. Specifically, the study highlighted that individuals with AD had a 64% higher chance of receiving a calcium prescription and a 125% higher likelihood of being referred for screening within two years of their diagnosis.
Despite these increased rates of screening and treatment, there remains a question about whether such efforts are effectively reducing the risk of osteoporosis and fractures in this vulnerable group. Factors such as age, sex, ethnic background, and use of analgesics also played significant roles in the treatment pathways for these patients, indicating that while there are advancements in management, the overall effectiveness still requires further investigation.
Read More
9
Combination therapy for osteoporosis
Effect of salmon calcitonin combined with calcium antagonist on blood calcium and phosphorus ion concentration in osteoporosis rats.
Relevant combination treatment exploration.
We explored how salmon calcitonin (sCT) works in tandem with calcium antagonists—specifically verapamil, nifedipine, and diltiazem—to influence blood calcium and phosphorus levels in female rats with osteoporosis post-ovarian removal.
The study involved a systematic approach where we administered these combinations to different groups of osteoporotic rats and measured their blood levels. Our findings revealed that combining sCT with nifedipine had a particularly strong effect in lowering both calcium and phosphorus in the blood, outperforming the use of sCT alone.
Our analysis indicated that while sCT with nifedipine was most effective, the combinations with verapamil and diltiazem also showed beneficial effects, albeit to a lesser extent. These insights provide valuable information on how combination therapies might be targeted for treating postmenopausal osteoporosis, potentially paving the way for more effective treatment options in human patients.
The study involved a systematic approach where we administered these combinations to different groups of osteoporotic rats and measured their blood levels. Our findings revealed that combining sCT with nifedipine had a particularly strong effect in lowering both calcium and phosphorus in the blood, outperforming the use of sCT alone.
Our analysis indicated that while sCT with nifedipine was most effective, the combinations with verapamil and diltiazem also showed beneficial effects, albeit to a lesser extent. These insights provide valuable information on how combination therapies might be targeted for treating postmenopausal osteoporosis, potentially paving the way for more effective treatment options in human patients.
Read More
Most Useful Reviews
9.5
Bone mass enhancement
Good way to translate calcium into bone mass! 21st Century Calcium 600 Plus D Plus Minerals is part of my comprehensive programme to maintain and increase my bone mass. For many years, my bone scans indicated I had osteopenia, a precursor to osteoporosis. I researched how calcium enters the bones and discovered that large doses of powdered marble or oyster shell don’t necessarily increase bone mass. That process requires minerals to help absorb calcium properly. I take 600mg at bedtime, which also aids my sleep. Most doctors advise a maximum of 1200mg daily. Dietary calcium is best, supplemented by exercise, though I don't do as much as I should. By the way, I am pleased to say my osteopenia diagnosis has vanished! My bone scan reveals a 4% increase in bone mass, and my doctor is astonished. Last year, I saw an additional 1% increase.
Read More
9.5
Improves bone health
Calcium is excellent for bones and aids in increasing height during adolescence. It alleviates dental pain and helps repair fractures quickly, making it beneficial for osteoporosis. Starting at 25, particularly after pregnancy and lactation, is advisable. Women need calcium, and this type includes vitamin D for better absorption. However, be cautious of iron supplements and avoid liver on the day of consumption. Stay safe! 💜💜💜
Read More
9.5
Enhances bone density
The 600+D3 Plus Minerals supplement is specially formulated to support bone health. It contains essential vitamins and minerals crucial for strong bones. Users have reported significant improvements in bone density and strength after regular use, particularly for those at risk of osteoporosis or other bone-related issues.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7
- All Researches
9
Calcium complex enhances bone health
A calcium-loaded complex based on Antarctic krill protein and supplemented with pectin promotes calcium absorption and bone health.
Study shows complex enhances calcium
Our research explored the effects of a new calcium-loaded complex, made from Antarctic krill protein and enriched with pectin, on calcium absorption and bone health in mice with calcium deficiency. We created a model that simulated calcium deficiency, which is a significant concern as it can contribute to osteoporosis.
We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.
Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health.
We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.
Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health.
Read More
9
Combination therapy for osteoporosis
Effect of salmon calcitonin combined with calcium antagonist on blood calcium and phosphorus ion concentration in osteoporosis rats.
Relevant combination treatment exploration.
We explored how salmon calcitonin (sCT) works in tandem with calcium antagonists—specifically verapamil, nifedipine, and diltiazem—to influence blood calcium and phosphorus levels in female rats with osteoporosis post-ovarian removal.
The study involved a systematic approach where we administered these combinations to different groups of osteoporotic rats and measured their blood levels. Our findings revealed that combining sCT with nifedipine had a particularly strong effect in lowering both calcium and phosphorus in the blood, outperforming the use of sCT alone.
Our analysis indicated that while sCT with nifedipine was most effective, the combinations with verapamil and diltiazem also showed beneficial effects, albeit to a lesser extent. These insights provide valuable information on how combination therapies might be targeted for treating postmenopausal osteoporosis, potentially paving the way for more effective treatment options in human patients.
The study involved a systematic approach where we administered these combinations to different groups of osteoporotic rats and measured their blood levels. Our findings revealed that combining sCT with nifedipine had a particularly strong effect in lowering both calcium and phosphorus in the blood, outperforming the use of sCT alone.
Our analysis indicated that while sCT with nifedipine was most effective, the combinations with verapamil and diltiazem also showed beneficial effects, albeit to a lesser extent. These insights provide valuable information on how combination therapies might be targeted for treating postmenopausal osteoporosis, potentially paving the way for more effective treatment options in human patients.
Read More
8
Calcium's role in osteoporosis explored
Is there a disparity in osteoporosis referral and treatment among people with affective disorders? A ten-year data linkage study.
Moderate relevance due to focus
We sought to understand whether individuals with affective disorders (AD) receive different levels of osteoporosis treatment compared to those without these mental health conditions. To do this, we analyzed a large group of people over a ten-year period, looking at how often patients with AD received calcium prescriptions and referrals for osteoporosis screening.
Our findings show that people with AD were more likely to receive calcium treatments, including calcium alone and calcium combined with vitamin D, compared to healthy controls. Specifically, the study highlighted that individuals with AD had a 64% higher chance of receiving a calcium prescription and a 125% higher likelihood of being referred for screening within two years of their diagnosis.
Despite these increased rates of screening and treatment, there remains a question about whether such efforts are effectively reducing the risk of osteoporosis and fractures in this vulnerable group. Factors such as age, sex, ethnic background, and use of analgesics also played significant roles in the treatment pathways for these patients, indicating that while there are advancements in management, the overall effectiveness still requires further investigation.
Our findings show that people with AD were more likely to receive calcium treatments, including calcium alone and calcium combined with vitamin D, compared to healthy controls. Specifically, the study highlighted that individuals with AD had a 64% higher chance of receiving a calcium prescription and a 125% higher likelihood of being referred for screening within two years of their diagnosis.
Despite these increased rates of screening and treatment, there remains a question about whether such efforts are effectively reducing the risk of osteoporosis and fractures in this vulnerable group. Factors such as age, sex, ethnic background, and use of analgesics also played significant roles in the treatment pathways for these patients, indicating that while there are advancements in management, the overall effectiveness still requires further investigation.
Read More
7
Calcium's complex effect on mineralization
miR-125b differentially impacts mineralization in dexamethasone and calcium-treated human mesenchymal stem cells.
Calcium impacts analyzed alongside dexamethasone
We explored how calcium treatment influences bone mineralization, particularly in the context of osteoporosis. Our study involved human mesenchymal stem cells (hMSCs) that were cultured in two different environments: one with calcium and another with dexamethasone, a medication often used to treat inflammation and other conditions.
Interestingly, while both treatments increased mineralization of hMSCs, we noted that levels of a specific microRNA, miR-125b, decreased with exposure to either calcium or dexamethasone. When we introduced a miR-125b mimic in the dexamethasone-treated cells, mineralization increased; however, it did the opposite in the calcium-treated cells. This suggests that calcium's effect can vary significantly depending on the context in which it is applied.
We also identified key targets of miR-125b that play roles in bone development, highlighting the complexity behind how calcium treatments might work in conjunction with other factors like dexamethasone. Overall, our findings contribute to a deeper understanding of bone metabolism and suggest that while calcium is important, its effectiveness might not be straightforward and may require further exploration.
Interestingly, while both treatments increased mineralization of hMSCs, we noted that levels of a specific microRNA, miR-125b, decreased with exposure to either calcium or dexamethasone. When we introduced a miR-125b mimic in the dexamethasone-treated cells, mineralization increased; however, it did the opposite in the calcium-treated cells. This suggests that calcium's effect can vary significantly depending on the context in which it is applied.
We also identified key targets of miR-125b that play roles in bone development, highlighting the complexity behind how calcium treatments might work in conjunction with other factors like dexamethasone. Overall, our findings contribute to a deeper understanding of bone metabolism and suggest that while calcium is important, its effectiveness might not be straightforward and may require further exploration.
Read More
5
Calcium's risks for kidney stones
Association between calcium and vitamin D supplementation and increased risk of kidney stone formation in patients with osteoporosis in Southwest China: a cross-sectional study.
Addresses key osteoporosis concerns
We explored the effects of calcium and vitamin D supplementation on osteoporosis, particularly focusing on the risk of kidney stones. In our study, 204 older adults in southwest China took daily doses of calcium and vitamin D for at least a year. We used various statistical analyses to understand the relationship between these supplements and kidney stone formation.
Our findings reveal that there is a potential link between the use of calcium supplements for osteoporosis and an increased risk of developing kidney stones. It seems that a history of kidney stones can elevate the likelihood of experiencing them again while undergoing such supplementation, likely due to higher urinary calcium levels.
While calcium is essential for bone health, our results suggest that patients need to be cautious. This research highlights the importance of monitoring kidney health while receiving calcium and vitamin D treatment to prevent complications like kidney stones.
Our findings reveal that there is a potential link between the use of calcium supplements for osteoporosis and an increased risk of developing kidney stones. It seems that a history of kidney stones can elevate the likelihood of experiencing them again while undergoing such supplementation, likely due to higher urinary calcium levels.
While calcium is essential for bone health, our results suggest that patients need to be cautious. This research highlights the importance of monitoring kidney health while receiving calcium and vitamin D treatment to prevent complications like kidney stones.
Read More
User Reviews
USERS' SCORE
Good
Based on 12 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Bone mass enhancement
Good way to translate calcium into bone mass! 21st Century Calcium 600 Plus D Plus Minerals is part of my comprehensive programme to maintain and increase my bone mass. For many years, my bone scans indicated I had osteopenia, a precursor to osteoporosis. I researched how calcium enters the bones and discovered that large doses of powdered marble or oyster shell don’t necessarily increase bone mass. That process requires minerals to help absorb calcium properly. I take 600mg at bedtime, which also aids my sleep. Most doctors advise a maximum of 1200mg daily. Dietary calcium is best, supplemented by exercise, though I don't do as much as I should. By the way, I am pleased to say my osteopenia diagnosis has vanished! My bone scan reveals a 4% increase in bone mass, and my doctor is astonished. Last year, I saw an additional 1% increase.
Read More
9.5
Improves bone health
Calcium is excellent for bones and aids in increasing height during adolescence. It alleviates dental pain and helps repair fractures quickly, making it beneficial for osteoporosis. Starting at 25, particularly after pregnancy and lactation, is advisable. Women need calcium, and this type includes vitamin D for better absorption. However, be cautious of iron supplements and avoid liver on the day of consumption. Stay safe! 💜💜💜
Read More
9.5
Enhances bone density
The 600+D3 Plus Minerals supplement is specially formulated to support bone health. It contains essential vitamins and minerals crucial for strong bones. Users have reported significant improvements in bone density and strength after regular use, particularly for those at risk of osteoporosis or other bone-related issues.
Read More
8.3
Effective for elders
It is a cost-effective and chewable option that significantly improves osteoporosis. The elders in our family appreciate its positive effects.
8.8
Supports bone strength
On my rheumatologist's recommendation for my mother, who has joint issues and osteoporosis from menopause, we take this with vitamin C. She finds the capsules easy to swallow despite their size, and after a month, her calcium levels rose to optimum. This has been beneficial for her bone and joint health; she also reports stronger nails and less sensitivity in her teeth. I’m pleased with the results.
Read More
