' 
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7
USERS' SCORE
Good
Based on 12 Reviews
8.6
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Calcium (as Calcium Carbonate)
600 mg
46%
Top Medical Research Studies
9
Calcium complex enhances bone health
A calcium-loaded complex based on Antarctic krill protein and supplemented with pectin promotes calcium absorption and bone health.
Study shows complex enhances calcium
Our research explored the effects of a new calcium-loaded complex, made from Antarctic krill protein and enriched with pectin, on calcium absorption and bone health in mice with calcium deficiency. We created a model that simulated calcium deficiency, which is a significant concern as it can contribute to osteoporosis.
We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.
Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health.
We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.
Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health.
Read More
8
Calcium's role in osteoporosis explored
Is there a disparity in osteoporosis referral and treatment among people with affective disorders? A ten-year data linkage study.
Moderate relevance due to focus
We sought to understand whether individuals with affective disorders (AD) receive different levels of osteoporosis treatment compared to those without these mental health conditions. To do this, we analyzed a large group of people over a ten-year period, looking at how often patients with AD received calcium prescriptions and referrals for osteoporosis screening.
Our findings show that people with AD were more likely to receive calcium treatments, including calcium alone and calcium combined with vitamin D, compared to healthy controls. Specifically, the study highlighted that individuals with AD had a 64% higher chance of receiving a calcium prescription and a 125% higher likelihood of being referred for screening within two years of their diagnosis.
Despite these increased rates of screening and treatment, there remains a question about whether such efforts are effectively reducing the risk of osteoporosis and fractures in this vulnerable group. Factors such as age, sex, ethnic background, and use of analgesics also played significant roles in the treatment pathways for these patients, indicating that while there are advancements in management, the overall effectiveness still requires further investigation.
Our findings show that people with AD were more likely to receive calcium treatments, including calcium alone and calcium combined with vitamin D, compared to healthy controls. Specifically, the study highlighted that individuals with AD had a 64% higher chance of receiving a calcium prescription and a 125% higher likelihood of being referred for screening within two years of their diagnosis.
Despite these increased rates of screening and treatment, there remains a question about whether such efforts are effectively reducing the risk of osteoporosis and fractures in this vulnerable group. Factors such as age, sex, ethnic background, and use of analgesics also played significant roles in the treatment pathways for these patients, indicating that while there are advancements in management, the overall effectiveness still requires further investigation.
Read More
9
Combination therapy for osteoporosis
Effect of salmon calcitonin combined with calcium antagonist on blood calcium and phosphorus ion concentration in osteoporosis rats.
Relevant combination treatment exploration.
We explored how salmon calcitonin (sCT) works in tandem with calcium antagonists—specifically verapamil, nifedipine, and diltiazem—to influence blood calcium and phosphorus levels in female rats with osteoporosis post-ovarian removal.
The study involved a systematic approach where we administered these combinations to different groups of osteoporotic rats and measured their blood levels. Our findings revealed that combining sCT with nifedipine had a particularly strong effect in lowering both calcium and phosphorus in the blood, outperforming the use of sCT alone.
Our analysis indicated that while sCT with nifedipine was most effective, the combinations with verapamil and diltiazem also showed beneficial effects, albeit to a lesser extent. These insights provide valuable information on how combination therapies might be targeted for treating postmenopausal osteoporosis, potentially paving the way for more effective treatment options in human patients.
The study involved a systematic approach where we administered these combinations to different groups of osteoporotic rats and measured their blood levels. Our findings revealed that combining sCT with nifedipine had a particularly strong effect in lowering both calcium and phosphorus in the blood, outperforming the use of sCT alone.
Our analysis indicated that while sCT with nifedipine was most effective, the combinations with verapamil and diltiazem also showed beneficial effects, albeit to a lesser extent. These insights provide valuable information on how combination therapies might be targeted for treating postmenopausal osteoporosis, potentially paving the way for more effective treatment options in human patients.
Read More
Most Useful Reviews
9.5
Value for osteoporosis
21st Century Calcium Supplement 600 offers excellent value. As a sufferer of osteoporosis, taking calcium daily is essential, and buying a 400-tablet bottle at an affordable price is fantastic. It’s not in a gel cap, which suits me as a vegetarian.
Read More
9.5
Prevents osteoporosis
Century's strong calcium aids in the prevention of osteoporosis!
Read More
8.3
Bone health support
Suitable for fragility. My mother has osteoporosis, and the doctor suggested she take 600 milligrams. This is the best calcium formula I've had, although the pill is quite large, which may pose a swallowing challenge. It is, however, an important nutritional supplement for osteoporosis and bone issues.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7
- All Researches
9
Calcium complex enhances bone health
A calcium-loaded complex based on Antarctic krill protein and supplemented with pectin promotes calcium absorption and bone health.
Study shows complex enhances calcium
Our research explored the effects of a new calcium-loaded complex, made from Antarctic krill protein and enriched with pectin, on calcium absorption and bone health in mice with calcium deficiency. We created a model that simulated calcium deficiency, which is a significant concern as it can contribute to osteoporosis.
We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.
Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health.
We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.
Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health.
Read More
9
Combination therapy for osteoporosis
Effect of salmon calcitonin combined with calcium antagonist on blood calcium and phosphorus ion concentration in osteoporosis rats.
Relevant combination treatment exploration.
We explored how salmon calcitonin (sCT) works in tandem with calcium antagonists—specifically verapamil, nifedipine, and diltiazem—to influence blood calcium and phosphorus levels in female rats with osteoporosis post-ovarian removal.
The study involved a systematic approach where we administered these combinations to different groups of osteoporotic rats and measured their blood levels. Our findings revealed that combining sCT with nifedipine had a particularly strong effect in lowering both calcium and phosphorus in the blood, outperforming the use of sCT alone.
Our analysis indicated that while sCT with nifedipine was most effective, the combinations with verapamil and diltiazem also showed beneficial effects, albeit to a lesser extent. These insights provide valuable information on how combination therapies might be targeted for treating postmenopausal osteoporosis, potentially paving the way for more effective treatment options in human patients.
The study involved a systematic approach where we administered these combinations to different groups of osteoporotic rats and measured their blood levels. Our findings revealed that combining sCT with nifedipine had a particularly strong effect in lowering both calcium and phosphorus in the blood, outperforming the use of sCT alone.
Our analysis indicated that while sCT with nifedipine was most effective, the combinations with verapamil and diltiazem also showed beneficial effects, albeit to a lesser extent. These insights provide valuable information on how combination therapies might be targeted for treating postmenopausal osteoporosis, potentially paving the way for more effective treatment options in human patients.
Read More
8
Calcium's role in osteoporosis explored
Is there a disparity in osteoporosis referral and treatment among people with affective disorders? A ten-year data linkage study.
Moderate relevance due to focus
We sought to understand whether individuals with affective disorders (AD) receive different levels of osteoporosis treatment compared to those without these mental health conditions. To do this, we analyzed a large group of people over a ten-year period, looking at how often patients with AD received calcium prescriptions and referrals for osteoporosis screening.
Our findings show that people with AD were more likely to receive calcium treatments, including calcium alone and calcium combined with vitamin D, compared to healthy controls. Specifically, the study highlighted that individuals with AD had a 64% higher chance of receiving a calcium prescription and a 125% higher likelihood of being referred for screening within two years of their diagnosis.
Despite these increased rates of screening and treatment, there remains a question about whether such efforts are effectively reducing the risk of osteoporosis and fractures in this vulnerable group. Factors such as age, sex, ethnic background, and use of analgesics also played significant roles in the treatment pathways for these patients, indicating that while there are advancements in management, the overall effectiveness still requires further investigation.
Our findings show that people with AD were more likely to receive calcium treatments, including calcium alone and calcium combined with vitamin D, compared to healthy controls. Specifically, the study highlighted that individuals with AD had a 64% higher chance of receiving a calcium prescription and a 125% higher likelihood of being referred for screening within two years of their diagnosis.
Despite these increased rates of screening and treatment, there remains a question about whether such efforts are effectively reducing the risk of osteoporosis and fractures in this vulnerable group. Factors such as age, sex, ethnic background, and use of analgesics also played significant roles in the treatment pathways for these patients, indicating that while there are advancements in management, the overall effectiveness still requires further investigation.
Read More
7
Calcium's complex effect on mineralization
miR-125b differentially impacts mineralization in dexamethasone and calcium-treated human mesenchymal stem cells.
Calcium impacts analyzed alongside dexamethasone
We explored how calcium treatment influences bone mineralization, particularly in the context of osteoporosis. Our study involved human mesenchymal stem cells (hMSCs) that were cultured in two different environments: one with calcium and another with dexamethasone, a medication often used to treat inflammation and other conditions.
Interestingly, while both treatments increased mineralization of hMSCs, we noted that levels of a specific microRNA, miR-125b, decreased with exposure to either calcium or dexamethasone. When we introduced a miR-125b mimic in the dexamethasone-treated cells, mineralization increased; however, it did the opposite in the calcium-treated cells. This suggests that calcium's effect can vary significantly depending on the context in which it is applied.
We also identified key targets of miR-125b that play roles in bone development, highlighting the complexity behind how calcium treatments might work in conjunction with other factors like dexamethasone. Overall, our findings contribute to a deeper understanding of bone metabolism and suggest that while calcium is important, its effectiveness might not be straightforward and may require further exploration.
Interestingly, while both treatments increased mineralization of hMSCs, we noted that levels of a specific microRNA, miR-125b, decreased with exposure to either calcium or dexamethasone. When we introduced a miR-125b mimic in the dexamethasone-treated cells, mineralization increased; however, it did the opposite in the calcium-treated cells. This suggests that calcium's effect can vary significantly depending on the context in which it is applied.
We also identified key targets of miR-125b that play roles in bone development, highlighting the complexity behind how calcium treatments might work in conjunction with other factors like dexamethasone. Overall, our findings contribute to a deeper understanding of bone metabolism and suggest that while calcium is important, its effectiveness might not be straightforward and may require further exploration.
Read More
5
Calcium's risks for kidney stones
Association between calcium and vitamin D supplementation and increased risk of kidney stone formation in patients with osteoporosis in Southwest China: a cross-sectional study.
Addresses key osteoporosis concerns
We explored the effects of calcium and vitamin D supplementation on osteoporosis, particularly focusing on the risk of kidney stones. In our study, 204 older adults in southwest China took daily doses of calcium and vitamin D for at least a year. We used various statistical analyses to understand the relationship between these supplements and kidney stone formation.
Our findings reveal that there is a potential link between the use of calcium supplements for osteoporosis and an increased risk of developing kidney stones. It seems that a history of kidney stones can elevate the likelihood of experiencing them again while undergoing such supplementation, likely due to higher urinary calcium levels.
While calcium is essential for bone health, our results suggest that patients need to be cautious. This research highlights the importance of monitoring kidney health while receiving calcium and vitamin D treatment to prevent complications like kidney stones.
Our findings reveal that there is a potential link between the use of calcium supplements for osteoporosis and an increased risk of developing kidney stones. It seems that a history of kidney stones can elevate the likelihood of experiencing them again while undergoing such supplementation, likely due to higher urinary calcium levels.
While calcium is essential for bone health, our results suggest that patients need to be cautious. This research highlights the importance of monitoring kidney health while receiving calcium and vitamin D treatment to prevent complications like kidney stones.
Read More
User Reviews
USERS' SCORE
Good
Based on 12 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Value for osteoporosis
21st Century Calcium Supplement 600 offers excellent value. As a sufferer of osteoporosis, taking calcium daily is essential, and buying a 400-tablet bottle at an affordable price is fantastic. It’s not in a gel cap, which suits me as a vegetarian.
9.5
Prevents osteoporosis
Century's strong calcium aids in the prevention of osteoporosis!
8.3
Bone health support
Suitable for fragility. My mother has osteoporosis, and the doctor suggested she take 600 milligrams. This is the best calcium formula I've had, although the pill is quite large, which may pose a swallowing challenge. It is, however, an important nutritional supplement for osteoporosis and bone issues.
Read More
8.8
Addresses osteoporosis
Excellent! As we age, it's crucial to replenish calcium to combat osteoporosis. I love this supplement.
6.3
Slight improvement noted
I purchased this on my doctor’s advice to supplement my calcium intake due to signs of osteoporosis from my bone density test. The pill is large, so I cut it in half for easier consumption. After three months, my follow-up osteoporosis test showed a slight improvement.
