Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 33 Researches
7.7
USERS' SCORE
Good
Based on 13 Reviews
8
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Total Carbohydrate
<1 g
<1%‡
Vitamin C (as Ascorbic Acid & Sodium Ascorbate)
60 mg
67%
Vitamin B-6 (as Pyridoxine HCl)
5 mg
294%
Zinc (as Zinc Aspartate)
15 mg
136%
Top Medical Research Studies
9
In our recent study, we set out to explore the effectiveness of a 5% sodium L-ascorbyl-2-phosphate lotion, a stable form of vitamin C, for treating acne. We conducted a double-blind, controlled trial with 50 participants over 12 weeks, where half used the vitamin C lotion and the other half received a placebo.
Our findings revealed significant improvements in acne symptoms for those using the vitamin C lotion compared to the placebo group. We measured outcomes through various assessments, including a global evaluation by investigators and self-reported assessments by the subjects, along with lesion counts.
The results showed that the vitamin C lotion was not only effective but also well-tolerated, with side effects similar to those seen with the placebo. This adds a promising tool to the options available for acne treatment, suggesting that vitamin C might play a valuable role in skincare regimens aimed at combating acne.
Overall, our study supports the idea that vitamin C, in the form of sodium L-ascorbyl-2-phosphate, can help reduce acne, making it a noteworthy addition to acne treatment strategies.
Our findings revealed significant improvements in acne symptoms for those using the vitamin C lotion compared to the placebo group. We measured outcomes through various assessments, including a global evaluation by investigators and self-reported assessments by the subjects, along with lesion counts.
The results showed that the vitamin C lotion was not only effective but also well-tolerated, with side effects similar to those seen with the placebo. This adds a promising tool to the options available for acne treatment, suggesting that vitamin C might play a valuable role in skincare regimens aimed at combating acne.
Overall, our study supports the idea that vitamin C, in the form of sodium L-ascorbyl-2-phosphate, can help reduce acne, making it a noteworthy addition to acne treatment strategies.
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8
We explored how zinc affects acne through a systematic review and meta-analysis that looked at two main questions. First, we wanted to know if there are differences in zinc levels between people with acne and those without. Second, we examined how effective zinc treatments are for managing acne.
Our findings showed that individuals with acne had noticeably lower serum zinc levels compared to those in the control group. Furthermore, when we looked at treatments, those who received zinc showed a significant reduction in their inflammatory papule count—a common symptom of acne. Importantly, we noted that side effects from zinc supplementation were similar to those seen in other treatments, suggesting that zinc is safe to use.
Overall, acne patients appear to benefit from improved zinc levels, especially when zinc is used either on its own or alongside other acne treatments. This gives hope for those looking for effective ways to tackle acne issues!
Our findings showed that individuals with acne had noticeably lower serum zinc levels compared to those in the control group. Furthermore, when we looked at treatments, those who received zinc showed a significant reduction in their inflammatory papule count—a common symptom of acne. Importantly, we noted that side effects from zinc supplementation were similar to those seen in other treatments, suggesting that zinc is safe to use.
Overall, acne patients appear to benefit from improved zinc levels, especially when zinc is used either on its own or alongside other acne treatments. This gives hope for those looking for effective ways to tackle acne issues!
Read More
9
We aimed to explore how effective zinc sulphate is in treating mild to moderate acne compared to the well-known antibiotic lymecycline. In our study, we involved 100 participants who were randomly assigned to receive either zinc sulphate or lymecycline.
To measure the effectiveness of the treatments, we used the Global Acne Grading System and a special questionnaire focused on acne's impact on quality of life. After four and twelve weeks of treatment, we found that both treatments significantly reduced acne severity.
However, the results showed something interesting. The patients who took zinc sulphate reported greater improvements in their quality of life than those on lymecycline. This indicates that zinc not only helps with acne but may also lead to a better overall experience during treatment.
Our findings suggest that zinc sulphate could be a compelling alternative to lymecycline, providing similar clinical benefits without the risk of antibiotic resistance associated with long-term antibiotic use.
To measure the effectiveness of the treatments, we used the Global Acne Grading System and a special questionnaire focused on acne's impact on quality of life. After four and twelve weeks of treatment, we found that both treatments significantly reduced acne severity.
However, the results showed something interesting. The patients who took zinc sulphate reported greater improvements in their quality of life than those on lymecycline. This indicates that zinc not only helps with acne but may also lead to a better overall experience during treatment.
Our findings suggest that zinc sulphate could be a compelling alternative to lymecycline, providing similar clinical benefits without the risk of antibiotic resistance associated with long-term antibiotic use.
Read More
Most Useful Reviews
7.5
Skin restoration
9 people found this helpful
Wonderful supplement! This is precisely what I was seeking. Zinc is known as a beauty mineral: it restores the skin after acne, reduces sebum production, and has a complex effect on the skin, nails, and hair. Alcohol and caffeine contribute to increased excretion of this mineral. It was helpful - I like it!
Read More
9
Teenage acne solution
3 people found this helpful
Working! Helped to overcome acne in my teenage daughter!
Read More
9
Skin condition improvement
1 people found this helpful
Zinc is vital for our body. It helps improve skin condition, is effective against acne and pimples, strengthens bones, and contributes to immunity. A deficiency can impact the reproductive system. Thanks for the recommendation!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 33 Researches
7.7
- All Researches
9.5
We investigated the effectiveness of a novel microneedle patch designed for acne treatment, which incorporates zinc-based nanoparticles. This patch combines sodium hyaluronate with zinc porphyrin-based metal-organic frameworks and zinc oxide. By using ultrasound to release activated oxygen, we observed a remarkable antibacterial efficiency, achieving a 99.73% reduction in acne-causing bacteria within just 15 minutes.
Zinc plays a crucial role in this innovative approach. Not only does it help eliminate harmful bacteria, but it also appears to enhance skin health. The presence of zinc ions promotes the up-regulation of genes associated with DNA replication, which supports the growth of fibroblasts. This is a vital process for skin repair and rejuvenation, showing that zinc can potentially contribute to both the treatment and recovery of acne-affected skin.
Overall, our findings suggest that this microneedle patch, which utilizes zinc and ultrasound-responsive technology, represents a promising strategy for effectively managing acne without relying on traditional antibiotics.
Zinc plays a crucial role in this innovative approach. Not only does it help eliminate harmful bacteria, but it also appears to enhance skin health. The presence of zinc ions promotes the up-regulation of genes associated with DNA replication, which supports the growth of fibroblasts. This is a vital process for skin repair and rejuvenation, showing that zinc can potentially contribute to both the treatment and recovery of acne-affected skin.
Overall, our findings suggest that this microneedle patch, which utilizes zinc and ultrasound-responsive technology, represents a promising strategy for effectively managing acne without relying on traditional antibiotics.
Read More
9
We investigated how zinc treatment affects acne, particularly focusing on its potential benefits for those suffering from acne rosacea. The study observed that zinc sulfate solution at a concentration of 5% played a notable role in reducing the severity of acne rosacea symptoms.
Findings indicated that around 40% to 60% of patients experienced a moderate to good response after using zinc. This suggests that zinc could be helpful for individuals looking for alternatives or supplements in their acne treatment regimen.
However, it's important to acknowledge that while zinc showed positive results, the isolated effect of zinc alone cannot be fully determined. It might have worked in conjunction with other treatment factors, which complicates our understanding of its effectiveness.
Therefore, we emphasize the need for further studies to clarify exactly how zinc contributes to acne treatment outcomes and to evaluate its role alongside other therapies.
Findings indicated that around 40% to 60% of patients experienced a moderate to good response after using zinc. This suggests that zinc could be helpful for individuals looking for alternatives or supplements in their acne treatment regimen.
However, it's important to acknowledge that while zinc showed positive results, the isolated effect of zinc alone cannot be fully determined. It might have worked in conjunction with other treatment factors, which complicates our understanding of its effectiveness.
Therefore, we emphasize the need for further studies to clarify exactly how zinc contributes to acne treatment outcomes and to evaluate its role alongside other therapies.
Read More
9
We assessed the potential of zinc oxide nanoparticles in combating acne. Using biogenically synthesized zinc oxide, we mixed it with a polymer to create a topical nanogel aimed at treating acne. Through rigorous testing against acne-causing bacteria, we observed that these biogenic nanoparticles showed a promising antibacterial effect, particularly against Gram-positive bacteria.
Notably, the particle size of our biogenic zinc oxide nanoparticles measured around 20 nm, indicating a high degree of purity. When pitted against chemogenic counterparts, the biogenic version proved to be more effective. This suggests that zinc oxide, especially when produced biogenically, could be a valuable addition to skincare products targeting acne.
Moreover, the study highlights the environment-friendly aspect of using biogenic zinc oxide in skincare formulations, making it a preferable choice for those concerned about sustainability. Our findings suggest that these hybrid nanogels could serve as an effective solution against skin infections associated with acne, adding to their appeal in modern skincare.
Notably, the particle size of our biogenic zinc oxide nanoparticles measured around 20 nm, indicating a high degree of purity. When pitted against chemogenic counterparts, the biogenic version proved to be more effective. This suggests that zinc oxide, especially when produced biogenically, could be a valuable addition to skincare products targeting acne.
Moreover, the study highlights the environment-friendly aspect of using biogenic zinc oxide in skincare formulations, making it a preferable choice for those concerned about sustainability. Our findings suggest that these hybrid nanogels could serve as an effective solution against skin infections associated with acne, adding to their appeal in modern skincare.
Read More
We wanted to find out how effective a cleansing gel containing salicylic acid, zinc gluconate, and lipohydroxy acids is for treating truncal acne. Conducted over 84 days, our study included 51 individuals with mild to moderate acne, and we tracked various skin conditions like the number of acne lesions and the overall skin barrier health.
After regular use of the gel, we observed a significant reduction in total acne lesions—over half were improved by the end of the study. While non-inflammatory lesions saw a drop of 64% and inflammatory lesions were reduced by nearly 30%, the key point is that zinc gluconate was part of a trio of ingredients, making it challenging to pinpoint its specific contribution.
When we considered skin barrier function, a notable improvement was also measured—21.26% better at Day 84. Patients reported no significant side effects or intolerances, suggesting that the ingredients within the gel, including zinc, were well tolerated.
Overall, the evidence hints at zinc's potential benefits as part of a combination treatment against acne. But since it was used together with other active ingredients, we can't solely credit zinc for the results observed.
After regular use of the gel, we observed a significant reduction in total acne lesions—over half were improved by the end of the study. While non-inflammatory lesions saw a drop of 64% and inflammatory lesions were reduced by nearly 30%, the key point is that zinc gluconate was part of a trio of ingredients, making it challenging to pinpoint its specific contribution.
When we considered skin barrier function, a notable improvement was also measured—21.26% better at Day 84. Patients reported no significant side effects or intolerances, suggesting that the ingredients within the gel, including zinc, were well tolerated.
Overall, the evidence hints at zinc's potential benefits as part of a combination treatment against acne. But since it was used together with other active ingredients, we can't solely credit zinc for the results observed.
Read More
9
We aimed to explore how effective zinc sulphate is in treating mild to moderate acne compared to the well-known antibiotic lymecycline. In our study, we involved 100 participants who were randomly assigned to receive either zinc sulphate or lymecycline.
To measure the effectiveness of the treatments, we used the Global Acne Grading System and a special questionnaire focused on acne's impact on quality of life. After four and twelve weeks of treatment, we found that both treatments significantly reduced acne severity.
However, the results showed something interesting. The patients who took zinc sulphate reported greater improvements in their quality of life than those on lymecycline. This indicates that zinc not only helps with acne but may also lead to a better overall experience during treatment.
Our findings suggest that zinc sulphate could be a compelling alternative to lymecycline, providing similar clinical benefits without the risk of antibiotic resistance associated with long-term antibiotic use.
To measure the effectiveness of the treatments, we used the Global Acne Grading System and a special questionnaire focused on acne's impact on quality of life. After four and twelve weeks of treatment, we found that both treatments significantly reduced acne severity.
However, the results showed something interesting. The patients who took zinc sulphate reported greater improvements in their quality of life than those on lymecycline. This indicates that zinc not only helps with acne but may also lead to a better overall experience during treatment.
Our findings suggest that zinc sulphate could be a compelling alternative to lymecycline, providing similar clinical benefits without the risk of antibiotic resistance associated with long-term antibiotic use.
Read More
User Reviews
USERS' SCORE
Good
Based on 13 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Skin restoration
9 people found this helpful
Wonderful supplement! This is precisely what I was seeking. Zinc is known as a beauty mineral: it restores the skin after acne, reduces sebum production, and has a complex effect on the skin, nails, and hair. Alcohol and caffeine contribute to increased excretion of this mineral. It was helpful - I like it!
Read More
9
Teenage acne solution
3 people found this helpful
Working! Helped to overcome acne in my teenage daughter!
Read More
9
Skin condition improvement
1 people found this helpful
Zinc is vital for our body. It helps improve skin condition, is effective against acne and pimples, strengthens bones, and contributes to immunity. A deficiency can impact the reproductive system. Thanks for the recommendation!
Read More
9
Acne reduction
Zinc is part of numerous enzyme systems regulating metabolic processes. It helps get rid of acne, especially in adults. By increasing zinc levels, I’ve improved my health and noticed positive effects on my skin, proving beneficial for men of all ages.
Read More
9
Clearer skin
I bought this for my son on a beautician's advice to fight acne. His face has become much clearer, and he takes zinc in courses.
Read More
Frequently Asked Questions
7.5
Effective for acne
Useful for my acne problem; I've been using it for about two weeks without side effects. It works well for acne-prone skin.
9
Clearer skin
I bought this for my son on a beautician's advice to fight acne. His face has become much clearer, and he takes zinc in courses.
7.5
Improved hair and skin
Excellent zinc! I ordered it for my hair and skin. My acne became less noticeable, and my hair became stronger. It performs its function well. Delicious too!
9
Teenage acne solution
3 people found this helpful
Working! Helped to overcome acne in my teenage daughter!
7.5
Hormonal acne relief
1 people found this helpful
Very good product. It's effective for my hormonal acne, especially when used with vitamin E and vitamin C with rosehip. I've ordered another bottle.
7.5
Skin improvement seen
Good quality for the skin; I use this with other supplements as recommended by my doctor for acne-prone adult skin. It's assisting me—though not as dramatically as I hoped, it is improving my skin.
8
We explored how zinc treatment may help with inflammatory skin conditions like acne vulgaris, rosacea, and hidradenitis suppurativa. These conditions can appear quite similar, which makes diagnosing them a bit tricky. By examining gene expression data across these three disorders, we noticed that certain zinc-binding proteins were consistently elevated in all cases.
Our hypothesis centers around these proteins possibly sequestering zinc, which could promote inflammation due to local zinc deficiency. To investigate this further, we identified high-dose dietary zinc as a potential therapeutic option. This was tested and validated in an acne mouse model, showing promising results for its effectiveness in reducing the inflammation associated with acne.
Although the study specifically highlighted the isolated effect of zinc, it strongly suggests that incorporating high doses of dietary zinc might offer a new avenue for treatment. This could be an encouraging option for those struggling with acne, pointing to a novel approach grounded in scientific findings.
Our hypothesis centers around these proteins possibly sequestering zinc, which could promote inflammation due to local zinc deficiency. To investigate this further, we identified high-dose dietary zinc as a potential therapeutic option. This was tested and validated in an acne mouse model, showing promising results for its effectiveness in reducing the inflammation associated with acne.
Although the study specifically highlighted the isolated effect of zinc, it strongly suggests that incorporating high doses of dietary zinc might offer a new avenue for treatment. This could be an encouraging option for those struggling with acne, pointing to a novel approach grounded in scientific findings.
9
We investigated how zinc treatment affects acne, particularly focusing on its potential benefits for those suffering from acne rosacea. The study observed that zinc sulfate solution at a concentration of 5% played a notable role in reducing the severity of acne rosacea symptoms.
Findings indicated that around 40% to 60% of patients experienced a moderate to good response after using zinc. This suggests that zinc could be helpful for individuals looking for alternatives or supplements in their acne treatment regimen.
However, it's important to acknowledge that while zinc showed positive results, the isolated effect of zinc alone cannot be fully determined. It might have worked in conjunction with other treatment factors, which complicates our understanding of its effectiveness.
Therefore, we emphasize the need for further studies to clarify exactly how zinc contributes to acne treatment outcomes and to evaluate its role alongside other therapies.
Findings indicated that around 40% to 60% of patients experienced a moderate to good response after using zinc. This suggests that zinc could be helpful for individuals looking for alternatives or supplements in their acne treatment regimen.
However, it's important to acknowledge that while zinc showed positive results, the isolated effect of zinc alone cannot be fully determined. It might have worked in conjunction with other treatment factors, which complicates our understanding of its effectiveness.
Therefore, we emphasize the need for further studies to clarify exactly how zinc contributes to acne treatment outcomes and to evaluate its role alongside other therapies.
7
We delved into the effectiveness of oral zinc treatment for acne through a systematic review of randomized clinical trials. The study drew from numerous databases to pinpoint research that examined how zinc—and other nutraceuticals—could potentially alleviate acne symptoms.
Among the 42 studies reviewed, several demonstrated a possible benefit from various vitamins and botanicals, including zinc. Specifically, while zinc therapy was included, it was noted that gastrointestinal side effects were associated with it, which might deter some users. Overall, zinc's effectiveness in reducing acne lesions was not conclusively separated from other treatments, as the results showed mixed findings across different studies.
Therefore, while zinc may play a role in improving acne symptoms, it's essential for users to be aware of the potential adverse effects and the treatment's variability in individual responses. More extensive and well-structured trials are likely needed to clarify zinc's precise impact in treating acne.
Among the 42 studies reviewed, several demonstrated a possible benefit from various vitamins and botanicals, including zinc. Specifically, while zinc therapy was included, it was noted that gastrointestinal side effects were associated with it, which might deter some users. Overall, zinc's effectiveness in reducing acne lesions was not conclusively separated from other treatments, as the results showed mixed findings across different studies.
Therefore, while zinc may play a role in improving acne symptoms, it's essential for users to be aware of the potential adverse effects and the treatment's variability in individual responses. More extensive and well-structured trials are likely needed to clarify zinc's precise impact in treating acne.
8
Zinc levels increased during treatment
We observed the effects of isotretinoin on patients with acne vulgaris, particularly focusing on how zinc interacts with this treatment. During the study, plasma samples were collected from 35 participants before and after three months of isotretinoin therapy.
Interestingly, we found that zinc levels increased significantly after treatment, especially in male patients. This increase suggests that zinc may play a supportive role in managing acne alongside isotretinoin. However, it's important to note that the study did not isolate zinc's effects as a treatment on its own, which leaves some questions about its direct effectiveness for acne alone.
Additionally, we noted changes in other trace elements like phosphorus, magnesium, and potassium. These changes could indicate potential impacts on kidney function, which highlights the need for careful monitoring during isotretinoin treatment. Regardless of the promising rise in zinc levels, the overall effectiveness of zinc as a standalone treatment for acne remains unclear.
Interestingly, we found that zinc levels increased significantly after treatment, especially in male patients. This increase suggests that zinc may play a supportive role in managing acne alongside isotretinoin. However, it's important to note that the study did not isolate zinc's effects as a treatment on its own, which leaves some questions about its direct effectiveness for acne alone.
Additionally, we noted changes in other trace elements like phosphorus, magnesium, and potassium. These changes could indicate potential impacts on kidney function, which highlights the need for careful monitoring during isotretinoin treatment. Regardless of the promising rise in zinc levels, the overall effectiveness of zinc as a standalone treatment for acne remains unclear.
7
Zinc's effects on acne treatment
We explored the potential benefits of zinc in treating acne based on a review of available literature. This review examined various studies focusing on the use of zinc for acne vulgaris, along with its effectiveness for other skin conditions like leishmaniasis and hidradenitis suppurativa.
Through our search in MEDLINE, we found that zinc seems to have both antioxidant and immunomodulatory properties, which may contribute to its effectiveness in treating inflammatory conditions, including acne. While the evidence is promising, especially for those with zinc deficiency, it’s important to note that there’s still a need for further research to clarify how effective zinc can be when used on its own, without other treatments.
Patients experiencing acne might benefit from additional strategies, including zinc supplementation. However, the exact role of zinc as a standalone therapy still requires more investigation through large controlled trials.
Through our search in MEDLINE, we found that zinc seems to have both antioxidant and immunomodulatory properties, which may contribute to its effectiveness in treating inflammatory conditions, including acne. While the evidence is promising, especially for those with zinc deficiency, it’s important to note that there’s still a need for further research to clarify how effective zinc can be when used on its own, without other treatments.
Patients experiencing acne might benefit from additional strategies, including zinc supplementation. However, the exact role of zinc as a standalone therapy still requires more investigation through large controlled trials.
References
- Li L, Hajam I, McGee JS, Tang Z, Zhang Y, et al. Comparative transcriptome analysis of acne vulgaris, rosacea, and hidradenitis suppurativa supports high-dose dietary zinc as a therapeutic agent. Exp Dermatol. 2024;33:e15145. doi:10.1111/exd.15145
- Algarin YA, Pulumati A, Jaalouk D, Tan J, Nouri K. The role of vitamins and nutrients in rosacea. Arch Dermatol Res. 2024;316:142. doi:10.1007/s00403-024-02895-4
- Akman TC, Yazici M, Atila A, Mertoglu C. Analysis of Isotretinoin-Induced Alterations in the Levels of Plasma Trace Elements: Investigation of the Relationship Between Magnesium, Phosphorus, Potassium, Zinc, and Treatment-Related Side Effects. Biol Trace Elem Res. 2024;202:4858. doi:10.1007/s12011-023-04053-9
- Li L, Hajam I, McGee JS, Tang Z, Zhang Y, et al. Comparative Transcriptome Analysis of Acne vulgaris, Rosacea, and Hidradenitis Suppurativa Supports High Dose Dietary Zinc as a Therapeutic Agent. medRxiv. 2023. doi:10.1101/2023.11.28.23299152
- Shields A, Ly S, Wafae B, Chang YF, Manjaly P, et al. Safety and Effectiveness of Oral Nutraceuticals for Treating Acne: A Systematic Review. JAMA Dermatol. 2023;159:1373. doi:10.1001/jamadermatol.2023.3949
- Tan YY, Wong LS, Nyam KL, Wittayanarakul K, Zawawi NA, et al. Development and Evaluation of Topical Zinc Oxide Nanogels Formulation Using and Its Effect on Acne Vulgaris. Molecules. 2023;28. doi:10.3390/molecules28196749
- Xiang Y, Lu J, Mao C, Zhu Y, Wang C, et al. Ultrasound-triggered interfacial engineering-based microneedle for bacterial infection acne treatment. Sci Adv. 2023;9:eadf0854. doi:10.1126/sciadv.adf0854
- Towersey L, Correia P, Fajgenbaum Feiges M, Euzébio Gonçalves Junior J, Sant'Anna B, et al. Assessment of the Benefit of a Deep Cleansing Gel Containing Salicylic Acid 2%, Zinc Gluconate 0.2% and Lipohydroxy Acids 0.05% in Patients with Mild to Moderate Truncal Acne: Results from an Exploratory Study. Clin Cosmet Investig Dermatol. 2023;16:119. doi:10.2147/CCID.S394123
- Salah E. Oral Zinc as a Novel Adjuvant and Sparing Therapy for Systemic Isotretinoin in Acne Vulgaris: A Preliminary Comparative Study. J Clin Aesthet Dermatol. 2022;15:58.
- Naji HH, Al-Azawi RSA, Ibrahim NJ, Kzar HH. Investigation of the Role of Zn/Cu Index and its Correlation with Physiological Activity of SOD 1 and GRx in Males with Acne Vulgaris. Arch Razi Inst. 2022;77:623. doi:10.22092/ARI.2021.356857.1928
- Searle T, Ali FR, Al-Niaimi F. Zinc in dermatology. J Dermatolog Treat. 2022;33:2455. doi:10.1080/09546634.2022.2062282
- Poizeau F, Plantier F, Bell H, Moyal-Barracco M. Vulvar Fordyce adenitis: A cohort of 45 women. Ann Dermatol Venereol. 2021;148:221. doi:10.1016/j.annder.2021.04.001
- Tolino E, Skroza N, Mambrin A, Proietti I, Bernardini N, et al. An Open-label Study Comparing Oral Zinc to Lymecycline in the Treatment of Acne Vulgaris. J Clin Aesthet Dermatol. 2021;14:56.
- Maillard A, Pastor D, Merat R. Anti-PD-1-Induced Hidradenitis Suppurativa. Dermatopathology (Basel). 2021;8:37. doi:10.3390/dermatopathology8010007
- Abendrot M, Płuciennik E, Felczak A, Zawadzka K, Piątczak E, et al. Zinc(II) Complexes of Amino Acids as New Active Ingredients for Anti-Acne Dermatological Preparations. Int J Mol Sci. 2021;22. doi:10.3390/ijms22041641
- Yee BE, Richards P, Sui JY, Marsch AF. Serum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta-analysis. Dermatol Ther. 2020;33:e14252. doi:10.1111/dth.14252
- Sharara MA, Fawaz GA, El Samahy MH. Efficacy of tranexamic acid solution versus vitamin C solution after micro-needling in treatment of persistent post acne erythema: a split face clinical and 3DAntera camera comparative study. Arch Dermatol Res. 2024;317:150. doi:10.1007/s00403-024-03582-0
- Golonka I, Łukasiewicz IW, Sebastiańczyk A, Greber KE, Sawicki W, et al. The Influence of the Amphiphilic Properties of Peptides on the Phosphatidylinositol Monolayer in the Presence of Ascorbic Acid. Int J Mol Sci. 2024;25. doi:10.3390/ijms252312484
- Hu JK, Quinonez RL, Antasiuk V, Waibel J. Treatment of Acne Vulgaris-Associated Post-Inflammatory Dyschromia With Combination of Non-Ablative Laser Therapy and Topical Antioxidants. J Drugs Dermatol. 2024;23:769. doi:10.36849/JDD.8309
- Abbas MAM, Elgamal EEAE, Zaky MS, Elsaie ML. Microneedling with topical vitamin C versus microneedling with topical insulin in the treatment of atrophic post-acne scars: A split-face study. Dermatol Ther. 2022;35:e15376. doi:10.1111/dth.15376
- Sawutdeechaikul P, Kanokrungsee S, Sahaspot T, Thadvibun K, Banlunara W, et al. Detachable dissolvable microneedles: intra-epidermal and intradermal diffusion, effect on skin surface, and application in hyperpigmentation treatment. Sci Rep. 2021;11:24114. doi:10.1038/s41598-021-03503-5
- Amer SS, Nasr M, Abdel-Aziz RTA, Moftah NH, El Shaer A, et al. Cosm-nutraceutical nanovesicles for acne treatment: Physicochemical characterization and exploratory clinical experimentation. Int J Pharm. 2020;577:119092. doi:10.1016/j.ijpharm.2020.119092
- Vasanth S, Dubey A, G S R, Lewis SA, Ghate VM, et al. Development and Investigation of Vitamin C-Enriched Adapalene-Loaded Transfersome Gel: a Collegial Approach for the Treatment of Acne Vulgaris. AAPS PharmSciTech. 2020;21:61. doi:10.1208/s12249-019-1518-5
- Khan H, Akhtar N, Ali A. Assessment of Combined Ascorbyl Palmitate (AP) and Sodium Ascorbyl Phosphate (SAP) on Facial Skin Sebum Control in Female Healthy Volunteers. Drug Res (Stuttg). 2017;67:52. doi:10.1055/s-0042-118171
- Jain A, Garg NK, Jain A, Kesharwani P, Jain AK, et al. A synergistic approach of adapalene-loaded nanostructured lipid carriers, and vitamin C co-administration for treating acne. Drug Dev Ind Pharm. 2016;42:897. doi:10.3109/03639045.2015.1104343
- Lee WJ, Kim SL, Choe YS, Jang YH, Lee SJ, et al. Magnesium Ascorbyl Phosphate Regulates the Expression of Inflammatory Biomarkers in Cultured Sebocytes. Ann Dermatol. 2015;27:376. doi:10.5021/ad.2015.27.4.376
- Ikeno H, Apel M, Zouboulis C, Luger TA, Böhm M. L-Ascorbyl-2-phosphate attenuates NF-κB signaling in SZ95 sebocytes without affecting IL-6 and IL-8 secretion. Arch Dermatol Res. 2015;307:595. doi:10.1007/s00403-015-1565-z
- Chawla S. Split Face Comparative Study of Microneedling with PRP Versus Microneedling with Vitamin C in Treating Atrophic Post Acne Scars. J Cutan Aesthet Surg. 2014;7:209. doi:10.4103/0974-2077.150742
- Iinuma K, Noguchi N, Nakaminami H, Sasatsu M, Nishijima S, et al. Susceptibility of Propionibacterium acnes isolated from patients with acne vulgaris to zinc ascorbate and antibiotics. Clin Cosmet Investig Dermatol. 2011;4:161. doi:10.2147/CCID.S23840
- Woolery-Lloyd H, Baumann L, Ikeno H. Sodium L-ascorbyl-2-phosphate 5% lotion for the treatment of acne vulgaris: a randomized, double-blind, controlled trial. J Cosmet Dermatol. 2010;9:22. doi:10.1111/j.1473-2165.2010.00480.x
- Burgess C. Topical vitamins. J Drugs Dermatol. 2008;7:s2.
- Klock J, Ikeno H, Ohmori K, Nishikawa T, Vollhardt J, et al. Sodium ascorbyl phosphate shows in vitro and in vivo efficacy in the prevention and treatment of acne vulgaris. Int J Cosmet Sci. 2005;27:171. doi:10.1111/j.1467-2494.2005.00263.x
- Fujishiro M, Yahagi S, Takemi S, Nakahara M, Sakai T, et al. Pyridoxine stimulates filaggrin production in human epidermal keratinocytes. Mol Biol Rep. 2021;48:5513. doi:10.1007/s11033-021-06563-y
