We investigated the impact of dispersible zinc tablets on postoperative sore throat (POST) experienced by patients after endotracheal intubation. In our study, 88 patients were divided into two groups. One group received a 40 mg zinc tablet, while the other received a placebo 30 minutes before their surgery.
Our findings revealed that the zinc group reported significantly fewer instances of POST at the 4-hour mark compared to the placebo group. Specifically, only 6.8% of patients in the zinc group experienced POST, while a higher 31.8% in the placebo group did. Furthermore, none of the patients taking zinc reported severe sore throat, a stark contrast to three patients in the placebo group who did.
Additionally, we noted lower severity ratings for sore throat in the zinc group at various time intervals post-surgery. The results emphasize that taking zinc tablets before surgery can effectively mitigate the incidence and discomfort of sore throat following intubation, presenting a simple solution for a common postoperative issue.
Read More
9
Zinc reduces postoperative sore throat
The Effect of Zinc Lozenge on Postoperative Sore Throat: A Prospective Randomized, Double-Blinded, Placebo-Controlled Study.
We explored the potential benefits of zinc lozenges for easing postoperative sore throat (POST), a common discomfort following endotracheal intubation. By conducting a randomized, double-blinded trial with 79 patients undergoing low- to moderate-risk surgeries, we divided participants into two groups: one received zinc lozenges, while the other was given a placebo.
Our findings revealed promising results. At the crucial four-hour mark post-surgery, only 7% of patients who took zinc experienced POST, compared to 29% in the placebo group. Interestingly, the difference was even more pronounced right after surgery, where the zinc group reported a 0% incidence of POST versus 24% for the control group.
Moreover, the severity of sore throat symptoms was notably less intense among those in the zinc group. Those with mild and moderate sore throat pains reported significantly lower severity scores. These results suggest that a single dose of 40 mg of zinc lozenges taken just 30 minutes before surgery can greatly aid in reducing both the occurrence and discomfort of POST in the early hours after surgery.
Read More
9.5
Zinc reduces postoperative sore throat
A randomised, double-blind, comparative study of preoperative magnesium sulphate versus zinc sulphate gargle for prevention of postoperative sore throat following endotracheal intubation.
We conducted a study to understand how well zinc can help prevent postoperative sore throat (POST) after endotracheal intubation. We compared the effects of gargling with zinc sulphate versus magnesium sulphate in a controlled trial involving 132 patients. Those in the zinc group received a solution with 40 mg of elemental zinc, while the magnesium group used 20 mg/kg of magnesium sulphate, with a control group receiving only dextrose.
Our findings showed that the group using zinc sulphate experienced notably lower rates of sore throat compared to those using magnesium sulphate. Specifically, the incidence of mild POST was significantly lower in the zinc group, especially during the first four hours after surgery. Overall, zinc gargle proved to be more effective in reducing sore throat compared to magnesium sulphate, demonstrating its potential benefits in postoperative care.
These results highlight the importance of zinc as a simple yet effective intervention to reduce discomfort for patients following surgery. By using zinc gargle preoperatively, we can potentially improve patient outcomes related to postoperative sore throat.
Read More
Most Useful Reviews
10
Effective for prevention
258 people found this helpful
Wonderful! It truly works! I have enough of this drug for a long time and don't use it often. As soon as I notice the onset of a sore throat, after taking a few tablets a day, it disappears. The taste is pleasant. It’s worth having in stock for when immunity weakens. I recommend it!
Read More
10
Quick relief achieved
8 people found this helpful
I tested this drug when my throat hurt in early November, coinciding with my order's arrival. According to the instructions, when symptoms begin, dissolve up to 6 capsules a day. I took only 4, and by the next day, I was pleased to find the sore throat gone. I recommend taking it for 6 days. The tablets aren’t chewable, but are for dissolving.
Read More
7.5
Long-lasting effects
3 people found this helpful
I like this product. It lasts long, and when I notice the first signs of sore throat, taking several pills a day helps alleviate the issue. Its pleasant taste makes it a handy item to keep for boosting my immune system.
A randomised, double-blind, comparative study of preoperative magnesium sulphate versus zinc sulphate gargle for prevention of postoperative sore throat following endotracheal intubation.
We conducted a study to understand how well zinc can help prevent postoperative sore throat (POST) after endotracheal intubation. We compared the effects of gargling with zinc sulphate versus magnesium sulphate in a controlled trial involving 132 patients. Those in the zinc group received a solution with 40 mg of elemental zinc, while the magnesium group used 20 mg/kg of magnesium sulphate, with a control group receiving only dextrose.
Our findings showed that the group using zinc sulphate experienced notably lower rates of sore throat compared to those using magnesium sulphate. Specifically, the incidence of mild POST was significantly lower in the zinc group, especially during the first four hours after surgery. Overall, zinc gargle proved to be more effective in reducing sore throat compared to magnesium sulphate, demonstrating its potential benefits in postoperative care.
These results highlight the importance of zinc as a simple yet effective intervention to reduce discomfort for patients following surgery. By using zinc gargle preoperatively, we can potentially improve patient outcomes related to postoperative sore throat.
Read More
9.5
Zinc reduces postoperative sore throat
Preoperative oral zinc tablet decreases incidence of postoperative sore throat.
We investigated the impact of dispersible zinc tablets on postoperative sore throat (POST) experienced by patients after endotracheal intubation. In our study, 88 patients were divided into two groups. One group received a 40 mg zinc tablet, while the other received a placebo 30 minutes before their surgery.
Our findings revealed that the zinc group reported significantly fewer instances of POST at the 4-hour mark compared to the placebo group. Specifically, only 6.8% of patients in the zinc group experienced POST, while a higher 31.8% in the placebo group did. Furthermore, none of the patients taking zinc reported severe sore throat, a stark contrast to three patients in the placebo group who did.
Additionally, we noted lower severity ratings for sore throat in the zinc group at various time intervals post-surgery. The results emphasize that taking zinc tablets before surgery can effectively mitigate the incidence and discomfort of sore throat following intubation, presenting a simple solution for a common postoperative issue.
Read More
9
Zinc reduces postoperative sore throat
The Effect of Zinc Lozenge on Postoperative Sore Throat: A Prospective Randomized, Double-Blinded, Placebo-Controlled Study.
We explored the potential benefits of zinc lozenges for easing postoperative sore throat (POST), a common discomfort following endotracheal intubation. By conducting a randomized, double-blinded trial with 79 patients undergoing low- to moderate-risk surgeries, we divided participants into two groups: one received zinc lozenges, while the other was given a placebo.
Our findings revealed promising results. At the crucial four-hour mark post-surgery, only 7% of patients who took zinc experienced POST, compared to 29% in the placebo group. Interestingly, the difference was even more pronounced right after surgery, where the zinc group reported a 0% incidence of POST versus 24% for the control group.
Moreover, the severity of sore throat symptoms was notably less intense among those in the zinc group. Those with mild and moderate sore throat pains reported significantly lower severity scores. These results suggest that a single dose of 40 mg of zinc lozenges taken just 30 minutes before surgery can greatly aid in reducing both the occurrence and discomfort of POST in the early hours after surgery.
Read More
8
Zinc's role in sore throat treatment
The Effectiveness of a Dietary Supplement with Honey, Propolis, Extract, and Zinc in Children Affected by Acute Tonsillopharyngitis: An Open, Randomized, and Controlled Trial.
We evaluated a promising dietary supplement that combines honey, propolis, and zinc to see how effective it could be for children suffering from acute tonsillopharyngitis, a type of sore throat. In this open-label, randomized, and controlled study, we compared the supplement along with standard care against standard care alone over six days.
The results revealed that incorporating the supplement with standard care led to notable improvements in certain symptoms associated with sore throat, such as throat pain and swallowing difficulties by day four and six. Although zinc was part of the blend, it was challenging to pinpoint its independent effect, given that it was studied alongside honey and propolis.
Interestingly, only one child in the standard care group needed additional medications like ibuprofen, highlighting that the supplement may reduce the need for further treatment. Importantly, we did not report any adverse events, making this combination a potential safe addition to treatment.
Overall, while the study presents encouraging results regarding the adjunctive use of the supplement in treating sore throat, it remains unclear how much zinc alone contributes to its effectiveness.
Read More
8
Zinc's variable effectiveness for sore throat
Zinc deficits, mucositis, and mucosal macrophage perturbation: is there a relationship?
We examined recent findings regarding zinc's impact on sore throat, particularly in post-operative settings. Some studies have reported that specific zinc formulations, like polaprezinc, can effectively reduce symptoms associated with sore throat after procedures like endotracheal intubation.
Importantly, zinc sulfate showed mixed results, with one review suggesting it did not significantly decrease the occurrence or intensity of oral mucositis in cancer patients. However, there are indications that certain zinc preparations may still hold promise in specific contexts, such as managing sore throat post-surgery.
Overall, while zinc's benefits in sore throat treatment appear to vary, ongoing research explores the best applications and formulations of zinc to potentially ease discomfort. As such, individuals seeking relief should keep an eye on emerging studies that could clarify zinc's role in throat health.
Wonderful! It truly works! I have enough of this drug for a long time and don't use it often. As soon as I notice the onset of a sore throat, after taking a few tablets a day, it disappears. The taste is pleasant. It’s worth having in stock for when immunity weakens. I recommend it!
Read More
10
Quick relief achieved
8 people found this helpful
I tested this drug when my throat hurt in early November, coinciding with my order's arrival. According to the instructions, when symptoms begin, dissolve up to 6 capsules a day. I took only 4, and by the next day, I was pleased to find the sore throat gone. I recommend taking it for 6 days. The tablets aren’t chewable, but are for dissolving.
Read More
7.5
Long-lasting effects
3 people found this helpful
I like this product. It lasts long, and when I notice the first signs of sore throat, taking several pills a day helps alleviate the issue. Its pleasant taste makes it a handy item to keep for boosting my immune system.
Read More
9
Effective for colds
2 people found this helpful
This product tackles my sore throat effectively. The taste is pleasant, making it easy to take.
Read More
10
Pleasant and effective
1 people found this helpful
These tablets are tasty and easy to chew, with a good dosage that allows multiple intakes during the day. My sore throat subsided after a few uses.
A sore throat, also known as pharyngitis, is a common condition characterized by pain, scratchiness, or irritation of the throat. It can occur as a result of various factors, including viral infections like the common cold or flu, bacterial infections such as strep throat, allergies, dry air, or even irritants like smoke and pollution. Symptoms often manifest as a sensation of discomfort during swallowing and may be accompanied by swelling, redness, or the presence of white patches on the tonsils or throat lining.
Most sore throats are mild and resolve on their own within a week or so, often treated with home remedies such as warm salt water gargles, lozenges, and hydration. However, if the sore throat is severe, persistent, or associated with other concerning symptoms such as high fever, difficulty swallowing, or difficulty breathing, it's essential to consult a healthcare professional, as this may indicate a more serious condition that requires medical intervention. Proper diagnosis and treatment are crucial, especially if a bacterial infection is suspected, as it may necessitate antibiotics for effective treatment.
Zinc is a versatile metal known for its various applications in industry and health. It is a bluish-white metallic element represented by the symbol Zn and atomic number 30 on the periodic table. Zinc is primarily used for galvanizing steel to prevent rusting, in the manufacturing of alloys, and as a component in batteries. Additionally, zinc plays a crucial role in biological processes, making it an essential trace element in the human diet. It is involved in immune function, protein synthesis, wound healing, and DNA synthesis, highlighting its importance in maintaining overall health and well-being.
Zinc has been studied for its potential effects on the immune system, and some evidence suggests it may help alleviate sore throat symptoms. Particularly, zinc lozenges or syrups may shorten the duration of a sore throat when taken at the onset of symptoms. The reasoning behind this is that zinc can inhibit the replication of the virus responsible for the cold and boost immune response, thus potentially providing some relief.
However, it’s important to use zinc cautiously, as high doses can lead to side effects such as nausea or a bad taste in the mouth. Most health experts recommend opting for zinc in moderate doses, ideally through lozenges, which can also provide some soothing effects. While zinc might not be a cure-all, it can be a helpful part of a broader treatment plan that includes rest, hydration, and over-the-counter pain relievers. If your sore throat persists or is accompanied by other severe symptoms, consulting with a healthcare professional is advisable.
Based on user reviews, many customers report experiencing relief from sore throat symptoms relatively quickly after starting this supplement. For instance, several users mentioned that their sore throat subsided within a day or two of taking the tablets. One user shared that they noticed their discomfort was gone by the next day after following the recommended dosage of four capsules (Read Review). Another review indicated that symptoms alleviated after a couple of days of usage (Read Review).
Additionally, some users highlighted that they often began taking the supplement at the first sign of a sore throat, leading to prompt relief. It seems that the sooner one starts taking the supplement upon noticing symptoms, the more effective it may be. This is supported by reviews indicating consistent satisfaction with early intervention measures (Read Review; Read Review). Overall, if you're looking for quick results, beginning treatment as soon as you sense a sore throat could lead to faster relief.
Recent studies indicate that supplements containing zinc, especially when combined with other ingredients like honey and propolis, show promise as a treatment for sore throat, particularly in children with acute tonsillopharyngitis. In one randomized controlled trial, children receiving a honey, propolis, and zinc supplement experienced significant improvements in throat pain and swallowing difficulties compared to those receiving standard care alone, reducing the need for additional medications such as ibuprofen [1]. However, it remains challenging to pinpoint the exact contribution of zinc alone within these formulations, as multiple active ingredients are at play [2].
Furthermore, zinc has demonstrated efficacy in reducing postoperative sore throat (POST) when used as a gargle or lozenge prior to and following intubation procedures. Studies showed a marked reduction in the incidence of sore throat among patients using zinc compared to those given placebo treatments [4], [7]. Despite mixed results regarding its standalone effectiveness in non-surgical sore throat scenarios, zinc’s potential benefits in specific contexts warrant further investigation to clarify its role in sore throat management.
Many users have reported significant improvements in their sore throat symptoms after using this supplement. A common sentiment is that taking the product at the earliest signs of discomfort leads to quicker relief. For example, one user mentioned that their sore throat disappeared by the following day after taking the recommended dosage (Read Review), while another noted that noticeable improvement occurred within just a few uses (Read Review). Users often emphasize the importance of early intervention, which appears to contribute to the effectiveness of the tablets (Read Review; Read Review).
Moreover, several reviews highlight the pleasant taste as an added bonus, making it easier to adhere to the recommended use. The formulation, which combines zinc with vitamins, is viewed positively by many, as it not only helps alleviate sore throat symptoms but potentially offers immune support as well (Read Review; Read Review). As always, individual results may vary, and while the product has garnered positive feedback, effectiveness can differ from person to person.
Users report a generally positive experience when combining this supplement with other supplements to manage sore throat symptoms. Many have noted improved efficacy when combining this supplement with Vitamin B6 or C, stating it provides added immune support. For instance, one reviewer highlighted the synergistic benefits of zinc with vitamin C during cold seasons, expressing appreciation for its role in alleviating sore throat and runny nose symptoms, resulting in a quicker recovery (Read Review).
Additionally, many users mention taking this supplement at the first sign of symptoms, sometimes in conjunction with other remedies, leading to faster relief. A common trend among the reviews is the emphasis on early intervention with this zinc-based supplement, often yielding positive outcomes while potentially enhancing the effects of other supplements involved. A review specifically stated that the inclusion of B6 improved their overall wellbeing and effectiveness in soothing sore throat symptoms (Read Review). Overall, users are inclined to recommend this supplement as a versatile tool in their sore throat and cold management arsenal.
Based on user reviews, the right dose of Zinc for treating sore throat appears to vary, with users reporting success with different amounts. One user mentioned following the instructions to dissolve up to 6 capsules per day when symptoms begin, but personally opted for only 4 capsules, leading to a recovery by the next day Read Review. Another user expressed satisfaction with several doses throughout the day to alleviate their sore throat Read Review. Similarly, other reviewers commented on the effectiveness of multiple intakes, suggesting that taking anywhere from a few to several doses daily could be beneficial for rapid relief Read Review.
Additionally, some users noted that they started with the dosage at the first signs of a sore throat, recommending that it alleviates symptoms quickly Read Review. It's clear from these experiences that while some recommend adhering closely to the product's directions, there is flexibility in dosage that users feel comfortable with depending on their symptom severity. Overall, it seems that users find Zinc to be an effective remedy when taken proactively, making it a staple in their medicine cabinet during the cold season Read Review.
10
Quick relief achieved
8 people found this helpful
I tested this drug when my throat hurt in early November, coinciding with my order's arrival. According to the instructions, when symptoms begin, dissolve up to 6 capsules a day. I took only 4, and by the next day, I was pleased to find the sore throat gone. I recommend taking it for 6 days. The tablets aren’t chewable, but are for dissolving.
7.5
Quick sore throat relief
These are excellent for a sore throat. I find my throat feels better within a couple of days of using the zinc tablets. They taste pretty good too, which is an added bonus!
9
Quick help
It truly helps a lot! A fantastic new remedy that quickly alleviates sore throat!
10
100% effective
Zinc with cherry flavour is both tasty and healthy. I keep it on my desk; with the slightest sore throat, it helps me immensely.
10
Pleasant and effective
1 people found this helpful
These tablets are tasty and easy to chew, with a good dosage that allows multiple intakes during the day. My sore throat subsided after a few uses.
10
Effective for prevention
258 people found this helpful
Wonderful! It truly works! I have enough of this drug for a long time and don't use it often. As soon as I notice the onset of a sore throat, after taking a few tablets a day, it disappears. The taste is pleasant. It’s worth having in stock for when immunity weakens. I recommend it!
7.5
Immune support for sore throat
An excellent combination of zinc with Vitamin B6 that works well for sore throats and strengthens the immune system.
9
Improves condition
I really liked this zinc! I used it during and after Covid; it enhances my general wellbeing and is effective for sore throat. I dissolve the pill, and the relief is immediate. Initially, there was an unpleasant metallic taste, but that didn't persist. I highly recommend it!
9
Effective during illness
I really appreciate this brand. Zinc with vitamin C is essential during an epidemic for immune support. When I felt a sore throat and runny nose, these vitamins helped significantly. The cold subsided quickly, and I felt the need for them regularly.
7.5
Long-lasting effects
3 people found this helpful
I like this product. It lasts long, and when I notice the first signs of sore throat, taking several pills a day helps alleviate the issue. Its pleasant taste makes it a handy item to keep for boosting my immune system.
9
Pain relief confirmed
This good complex helps prevent illness and alleviates pain and sore throat.
8
Zinc's role in sore throat treatment
The Effectiveness of a Dietary Supplement with Honey, Propolis, Extract, and Zinc in Children Affected by Acute Tonsillopharyngitis: An Open, Randomized, and Controlled Trial.
We evaluated a promising dietary supplement that combines honey, propolis, and zinc to see how effective it could be for children suffering from acute tonsillopharyngitis, a type of sore throat. In this open-label, randomized, and controlled study, we compared the supplement along with standard care against standard care alone over six days.
The results revealed that incorporating the supplement with standard care led to notable improvements in certain symptoms associated with sore throat, such as throat pain and swallowing difficulties by day four and six. Although zinc was part of the blend, it was challenging to pinpoint its independent effect, given that it was studied alongside honey and propolis.
Interestingly, only one child in the standard care group needed additional medications like ibuprofen, highlighting that the supplement may reduce the need for further treatment. Importantly, we did not report any adverse events, making this combination a potential safe addition to treatment.
Overall, while the study presents encouraging results regarding the adjunctive use of the supplement in treating sore throat, it remains unclear how much zinc alone contributes to its effectiveness.
7
Zinc's role in sore throat relief
The Effects of a Dietary Supplement (PediaFlù) Plus Standard of Care in Children With Acute Tonsillopharyngitis/Rhinopharyngitis: Protocol for a Randomized Controlled Trial.
We targeted the effectiveness of a dietary supplement that includes zinc, among other ingredients, in treating acute tonsillopharyngitis and rhinopharyngitis in children. This trial was carefully designed to compare the supplement combined with standard care against standard care alone.
Our focus was on children aged 3 to 10 years suffering from sore throat symptoms. We employed a randomized, controlled setup, ensuring a solid methodological foundation for our findings. The primary goals included assessing severity of throat pain and the necessity for additional rescue medications.
The results highlighted the supplement's potential as an add-on treatment. While it shows promise in alleviating symptoms, we must note that we cannot isolate zinc's effects from other components like Pelargonium sidoides and propolis.
Ultimately, these insights could guide future treatments where antibiotics are avoided, especially when there's no streptococcal infection involved.
9.5
Zinc reduces postoperative sore throat
A randomised, double-blind, comparative study of preoperative magnesium sulphate versus zinc sulphate gargle for prevention of postoperative sore throat following endotracheal intubation.
We conducted a study to understand how well zinc can help prevent postoperative sore throat (POST) after endotracheal intubation. We compared the effects of gargling with zinc sulphate versus magnesium sulphate in a controlled trial involving 132 patients. Those in the zinc group received a solution with 40 mg of elemental zinc, while the magnesium group used 20 mg/kg of magnesium sulphate, with a control group receiving only dextrose.
Our findings showed that the group using zinc sulphate experienced notably lower rates of sore throat compared to those using magnesium sulphate. Specifically, the incidence of mild POST was significantly lower in the zinc group, especially during the first four hours after surgery. Overall, zinc gargle proved to be more effective in reducing sore throat compared to magnesium sulphate, demonstrating its potential benefits in postoperative care.
These results highlight the importance of zinc as a simple yet effective intervention to reduce discomfort for patients following surgery. By using zinc gargle preoperatively, we can potentially improve patient outcomes related to postoperative sore throat.
9
Zinc reduces postoperative sore throat
The Effect of Zinc Lozenge on Postoperative Sore Throat: A Prospective Randomized, Double-Blinded, Placebo-Controlled Study.
We explored the potential benefits of zinc lozenges for easing postoperative sore throat (POST), a common discomfort following endotracheal intubation. By conducting a randomized, double-blinded trial with 79 patients undergoing low- to moderate-risk surgeries, we divided participants into two groups: one received zinc lozenges, while the other was given a placebo.
Our findings revealed promising results. At the crucial four-hour mark post-surgery, only 7% of patients who took zinc experienced POST, compared to 29% in the placebo group. Interestingly, the difference was even more pronounced right after surgery, where the zinc group reported a 0% incidence of POST versus 24% for the control group.
Moreover, the severity of sore throat symptoms was notably less intense among those in the zinc group. Those with mild and moderate sore throat pains reported significantly lower severity scores. These results suggest that a single dose of 40 mg of zinc lozenges taken just 30 minutes before surgery can greatly aid in reducing both the occurrence and discomfort of POST in the early hours after surgery.
References
Cardinale F, Barattini DF, Martinucci V, Bordea MM, Barattini L, et al. The Effectiveness of a Dietary Supplement with Honey, Propolis, Extract, and Zinc in Children Affected by Acute Tonsillopharyngitis: An Open, Randomized, and Controlled Trial. Pharmaceuticals (Basel). 2024;17. doi:10.3390/ph17060804
Cardinale F, Barattini DF, Sbrocca F, Centi A, Giuntini G, et al. The Effects of a Dietary Supplement (PediaFlù) Plus Standard of Care in Children With Acute Tonsillopharyngitis/Rhinopharyngitis: Protocol for a Randomized Controlled Trial. JMIR Res Protoc. 2024;13:e53703. doi:10.2196/53703
Bhanwra A, Palta S, Saroa R, Saxena P, Bhanwra S, et al. Role of preoperative zinc, magnesium and budesonide gargles in Postoperative Sore Throat (POST) - a randomised control trial. BMC Anesthesiol. 2024;24:164. doi:10.1186/s12871-024-02534-5
Mondal AK, Maiti AK, Chattopadhyay S, Bhar D. A randomised, double-blind, comparative study of preoperative magnesium sulphate versus zinc sulphate gargle for prevention of postoperative sore throat following endotracheal intubation. Indian J Anaesth. 2023;67:S261. doi:10.4103/ija.ija_975_22
Sarkar T, Mandal T. Preoperative oral zinc tablet decreases incidence of postoperative sore throat. Indian J Anaesth. 2020;64:409. doi:10.4103/ija.IJA_959_19
Thomsen M, Vitetta L. Zinc deficits, mucositis, and mucosal macrophage perturbation: is there a relationship?. Curr Opin Clin Nutr Metab Care. 2019;22:365. doi:10.1097/MCO.0000000000000588
Farhang B, Grondin L. The Effect of Zinc Lozenge on Postoperative Sore Throat: A Prospective Randomized, Double-Blinded, Placebo-Controlled Study. Anesth Analg. 2018;126:78. doi:10.1213/ANE.0000000000002494
Sun GB, Sun N, Tang HH, Zhu QB, Wen W, et al. Zinc sulfate therapy of vocal process granuloma. Eur Arch Otorhinolaryngol. 2012;269:2087. doi:10.1007/s00405-012-1971-1
Prasad AS, Fitzgerald JT, Bao B, Beck FW, Chandrasekar PH. Duration of symptoms and plasma cytokine levels in patients with the common cold treated with zinc acetate. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 2000;133:245.