Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 12 Researches
8
USERS' SCORE
Good
Based on 3 Reviews
8.4
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Thiamin (as Thiamin Mononitrate, Vitamin B-1)
100 mg
8,333%
Riboflavin (Vitamin B-2)
100 mg
7,692%
Niacin (as Niacinamide)
100 mg
625%
Vitamin B-6 (as Pyridoxine HCl)
100 mg
5,882%
Folate
667 mcg DFE(400 mcg Folic Acid
167%
Vitamin B-12 (as Cyanocobalamin)
100 mcg
4,167%
Biotin
100 mcg
333%
Pantothenic Acid (as d-Calcium Pantothenate)
100 mg
2,000%
Calcium (as Calcium Carbonate & Dicalcium Phosphate)
124 mg
10%
Top Medical Research Studies
9
Our investigation looked into how Vitamin B affects behavior and neurotransmitter levels in rats undergoing stress-induced depression.
We set up three groups: a control group, a stressed group, and a stressed group receiving Vitamin B.
The results showed that Vitamin B improved neurotransmitter levels and reduced anxiety and depression-like behaviors in the rats. This suggests that Vitamin B could be beneficial in improving symptoms of depression driven by stress.
We set up three groups: a control group, a stressed group, and a stressed group receiving Vitamin B.
The results showed that Vitamin B improved neurotransmitter levels and reduced anxiety and depression-like behaviors in the rats. This suggests that Vitamin B could be beneficial in improving symptoms of depression driven by stress.
Read More
8
This study examined how dietary vitamin B6 and plasma levels of pyridoxal 5’-phosphate relate to depression in US adults. We analyzed data from nearly 25,000 people over five years, revealing that those with the highest vitamin B6 intake and plasma levels experienced a lower risk of depression.
Although these results are promising and suggest the benefits of a vitamin B6-rich diet, we also noted that further randomized controlled trials are needed to better understand the effects of vitamin B6 supplementation on mood.
Although these results are promising and suggest the benefits of a vitamin B6-rich diet, we also noted that further randomized controlled trials are needed to better understand the effects of vitamin B6 supplementation on mood.
Read More
8
Niacin shows promise for depression
We investigated how niacin (vitamin B3) impacts depression, particularly through a mouse model using lipopolysaccharide to induce depressive behaviors.
The study revealed that niacin significantly reduced signs of despair in mice, leading to more mobility in forced swimming tests.
It not only boosted important brain chemicals but also activated protective pathways that lessen neuroinflammation associated with depression.
Overall, the findings suggest that niacin could be a promising option for managing depression by addressing key neuroprotective mechanisms.
The study revealed that niacin significantly reduced signs of despair in mice, leading to more mobility in forced swimming tests.
It not only boosted important brain chemicals but also activated protective pathways that lessen neuroinflammation associated with depression.
Overall, the findings suggest that niacin could be a promising option for managing depression by addressing key neuroprotective mechanisms.
Read More
Most Useful Reviews
7.5
Alleviated symptoms
31 people found this helpful
I use it to relieve depression. I was feeling quite unwell when I discovered the impact of B vitamins online, prompting me to start taking them. As they are water-soluble, I noticed their effect relatively quickly. I believe the symptom has improved. If this is beneficial for you, I hope you appreciate it. Thank you.
Read More
9
Depression relief
18 people found this helpful
Super antidepressant! It mitigates severe mood swings and effectively combats depression. It warms the body internally, aiding in fat conversion to energy, while also restoring sleep. However, I experienced a significant allergy towards the end of my fourth can, causing facial swelling.
Read More
7.5
Enhanced confidence
6 people found this helpful
These vitamins have a good composition and dosage at a reasonable price. They improve bowel function and skin condition, support emotional health, and assist in managing stress and depression. After starting this supplement, I felt more self-confident and less anxious. They aid mental stability and recovery; I found them significantly beneficial!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 12 Researches
8
- All Researches
9.5
We explored a remarkable case of a 58-year-old cancer patient who exhibited depressive symptoms potentially linked to thiamine deficiency (TD). Initially suspected of having major depressive disorder, her condition transformed dramatically after receiving intravenous thiamine.
Within an hour of treatment, her distressing symptoms—palpitations, dyspnea, and suicidal thoughts—significantly improved. This observation underscores the importance of considering TD as a reversible cause when patients present with depression-like symptoms, especially in serious cases involving cancer.
Within an hour of treatment, her distressing symptoms—palpitations, dyspnea, and suicidal thoughts—significantly improved. This observation underscores the importance of considering TD as a reversible cause when patients present with depression-like symptoms, especially in serious cases involving cancer.
Read More
9
Our investigation looked into how Vitamin B affects behavior and neurotransmitter levels in rats undergoing stress-induced depression.
We set up three groups: a control group, a stressed group, and a stressed group receiving Vitamin B.
The results showed that Vitamin B improved neurotransmitter levels and reduced anxiety and depression-like behaviors in the rats. This suggests that Vitamin B could be beneficial in improving symptoms of depression driven by stress.
We set up three groups: a control group, a stressed group, and a stressed group receiving Vitamin B.
The results showed that Vitamin B improved neurotransmitter levels and reduced anxiety and depression-like behaviors in the rats. This suggests that Vitamin B could be beneficial in improving symptoms of depression driven by stress.
Read More
8
We explored the effects of a newly developed zinc-acetyl-l-carnitine complex on depression and neuroprotection. This innovative compound showed a remarkable 54% increase in antidepressant activity compared to standard acetyl-l-carnitine.
Additionally, it demonstrated the ability to alleviate pain and protect nerve cells against damage. While the results are promising, further studies are needed to fully understand its long-term effectiveness and safety for depression and related conditions.
Additionally, it demonstrated the ability to alleviate pain and protect nerve cells against damage. While the results are promising, further studies are needed to fully understand its long-term effectiveness and safety for depression and related conditions.
Read More
8
We explored whether combining antidepressants with low-dose methylfolate could improve outcomes for patients with depressive disorder. In this open-label trial, 44 participants received standard antidepressant treatment along with 800 µg of methylfolate daily for four weeks.
We used questionnaires to gauge depression levels throughout the study. The results suggested that this combination therapy might enhance treatment effectiveness compared to antidepressant monotherapy. Overall, it signals a promising avenue for those battling depression, pointing toward an approachable and potentially beneficial treatment strategy.
We used questionnaires to gauge depression levels throughout the study. The results suggested that this combination therapy might enhance treatment effectiveness compared to antidepressant monotherapy. Overall, it signals a promising avenue for those battling depression, pointing toward an approachable and potentially beneficial treatment strategy.
Read More
8
This study examined how dietary vitamin B6 and plasma levels of pyridoxal 5’-phosphate relate to depression in US adults. We analyzed data from nearly 25,000 people over five years, revealing that those with the highest vitamin B6 intake and plasma levels experienced a lower risk of depression.
Although these results are promising and suggest the benefits of a vitamin B6-rich diet, we also noted that further randomized controlled trials are needed to better understand the effects of vitamin B6 supplementation on mood.
Although these results are promising and suggest the benefits of a vitamin B6-rich diet, we also noted that further randomized controlled trials are needed to better understand the effects of vitamin B6 supplementation on mood.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Alleviated symptoms
31 people found this helpful
I use it to relieve depression. I was feeling quite unwell when I discovered the impact of B vitamins online, prompting me to start taking them. As they are water-soluble, I noticed their effect relatively quickly. I believe the symptom has improved. If this is beneficial for you, I hope you appreciate it. Thank you.
Read More
9
Depression relief
18 people found this helpful
Super antidepressant! It mitigates severe mood swings and effectively combats depression. It warms the body internally, aiding in fat conversion to energy, while also restoring sleep. However, I experienced a significant allergy towards the end of my fourth can, causing facial swelling.
Read More
7.5
Enhanced confidence
6 people found this helpful
These vitamins have a good composition and dosage at a reasonable price. They improve bowel function and skin condition, support emotional health, and assist in managing stress and depression. After starting this supplement, I felt more self-confident and less anxious. They aid mental stability and recovery; I found them significantly beneficial!
Read More
Frequently Asked Questions
7.5
Alleviated symptoms
31 people found this helpful
I use it to relieve depression. I was feeling quite unwell when I discovered the impact of B vitamins online, prompting me to start taking them. As they are water-soluble, I noticed their effect relatively quickly. I believe the symptom has improved. If this is beneficial for you, I hope you appreciate it. Thank you.
7.5
Enhanced confidence
6 people found this helpful
These vitamins have a good composition and dosage at a reasonable price. They improve bowel function and skin condition, support emotional health, and assist in managing stress and depression. After starting this supplement, I felt more self-confident and less anxious. They aid mental stability and recovery; I found them significantly beneficial!
9
Depression relief
18 people found this helpful
Super antidepressant! It mitigates severe mood swings and effectively combats depression. It warms the body internally, aiding in fat conversion to energy, while also restoring sleep. However, I experienced a significant allergy towards the end of my fourth can, causing facial swelling.
9
Our investigation looked into how Vitamin B affects behavior and neurotransmitter levels in rats undergoing stress-induced depression.
We set up three groups: a control group, a stressed group, and a stressed group receiving Vitamin B.
The results showed that Vitamin B improved neurotransmitter levels and reduced anxiety and depression-like behaviors in the rats. This suggests that Vitamin B could be beneficial in improving symptoms of depression driven by stress.
We set up three groups: a control group, a stressed group, and a stressed group receiving Vitamin B.
The results showed that Vitamin B improved neurotransmitter levels and reduced anxiety and depression-like behaviors in the rats. This suggests that Vitamin B could be beneficial in improving symptoms of depression driven by stress.
8
We explored the effects of a newly developed zinc-acetyl-l-carnitine complex on depression and neuroprotection. This innovative compound showed a remarkable 54% increase in antidepressant activity compared to standard acetyl-l-carnitine.
Additionally, it demonstrated the ability to alleviate pain and protect nerve cells against damage. While the results are promising, further studies are needed to fully understand its long-term effectiveness and safety for depression and related conditions.
Additionally, it demonstrated the ability to alleviate pain and protect nerve cells against damage. While the results are promising, further studies are needed to fully understand its long-term effectiveness and safety for depression and related conditions.
8
This study examined how dietary vitamin B6 and plasma levels of pyridoxal 5’-phosphate relate to depression in US adults. We analyzed data from nearly 25,000 people over five years, revealing that those with the highest vitamin B6 intake and plasma levels experienced a lower risk of depression.
Although these results are promising and suggest the benefits of a vitamin B6-rich diet, we also noted that further randomized controlled trials are needed to better understand the effects of vitamin B6 supplementation on mood.
Although these results are promising and suggest the benefits of a vitamin B6-rich diet, we also noted that further randomized controlled trials are needed to better understand the effects of vitamin B6 supplementation on mood.
7
We explored the effects of vitamin B12 on stress resilience and depression by using advanced techniques in a mouse model of chronic stress. Our findings linked vitamin B12 supplementation to increased Ttr expression, a protein associated with mood disorders.
Notably, vitamin B12 seemed to influence DNA changes that affect behaviors tied to stress and depression. However, this study primarily focused on the mechanisms rather than directly measuring improvements in human depression, highlighting the need for more research into exploring dietary solutions for mood-related concerns.
Notably, vitamin B12 seemed to influence DNA changes that affect behaviors tied to stress and depression. However, this study primarily focused on the mechanisms rather than directly measuring improvements in human depression, highlighting the need for more research into exploring dietary solutions for mood-related concerns.
8
We explored whether combining antidepressants with low-dose methylfolate could improve outcomes for patients with depressive disorder. In this open-label trial, 44 participants received standard antidepressant treatment along with 800 µg of methylfolate daily for four weeks.
We used questionnaires to gauge depression levels throughout the study. The results suggested that this combination therapy might enhance treatment effectiveness compared to antidepressant monotherapy. Overall, it signals a promising avenue for those battling depression, pointing toward an approachable and potentially beneficial treatment strategy.
We used questionnaires to gauge depression levels throughout the study. The results suggested that this combination therapy might enhance treatment effectiveness compared to antidepressant monotherapy. Overall, it signals a promising avenue for those battling depression, pointing toward an approachable and potentially beneficial treatment strategy.
8
Niacin shows promise for depression
We investigated how niacin (vitamin B3) impacts depression, particularly through a mouse model using lipopolysaccharide to induce depressive behaviors.
The study revealed that niacin significantly reduced signs of despair in mice, leading to more mobility in forced swimming tests.
It not only boosted important brain chemicals but also activated protective pathways that lessen neuroinflammation associated with depression.
Overall, the findings suggest that niacin could be a promising option for managing depression by addressing key neuroprotective mechanisms.
The study revealed that niacin significantly reduced signs of despair in mice, leading to more mobility in forced swimming tests.
It not only boosted important brain chemicals but also activated protective pathways that lessen neuroinflammation associated with depression.
Overall, the findings suggest that niacin could be a promising option for managing depression by addressing key neuroprotective mechanisms.
References
- Chen J, Liu J, Zhang P, Zhang S. [Effects of Vitamin B on Behaviors, Brain Monoamine Neurotransmitters, and Brain-Derived Neurotrophic Factor in Depressive Rats]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2025;56:206. doi:10.12182/20250160608
- Caro-Ramírez JY, Bazán LO, Piro OE, Echeverría GA, Jori K, et al. Exploring Zn(II)-Acetyl l-carnitine complex for simultaneous management of depression, chronic pain, and neuroprotection. J Inorg Biochem. 2025;267:112857. doi:10.1016/j.jinorgbio.2025.112857
- Siddique A, Khokhar MM, Waheed A, Naeem U, Aziz SA. Effect of combination therapy of methylfolate with antidepressants in patients with depressive disorder. BMC Pharmacol Toxicol. 2025;26:14. doi:10.1186/s40360-025-00846-x
- Lu J, Mao H, Tan Y, Luo G. Associations of Dietary Intake of Vitamin B6 and Plasma Pyridoxal 5'-Phosphate Level With Depression in US Adults: Findings From NHANES 2005-2010. Brain Behav. 2024;14:e70128. doi:10.1002/brb3.70128
- Samad N, Hameed A, Manzoor N, Shoukat S, Irfan A, et al. Antioxidant and neuro-modulatory effects of niacin prevent D-galactose-induced behavioral deficits and memory impairment. Exp Gerontol. 2024;198:112624. doi:10.1016/j.exger.2024.112624
- Stein G, Aly JS, Manzolillo A, Lange L, Riege K, et al. Transthyretin Orchestrates Vitamin B12-Induced Stress Resilience. Biol Psychiatry. 2025;97:54. doi:10.1016/j.biopsych.2024.07.009
- Pahlavani H, Masoudi M, Khoshroo N, Kakhki S, Mahdi Rezavanimehr M, et al. Vitamin B reversed anxiety and depression induced by adolescent nicotine withdrawal through alteration the inflammatory, oxidative and serotoninergic profiles in male rats. Biochem Pharmacol. 2023;217:115832. doi:10.1016/j.bcp.2023.115832
- Abdel Rasheed NO, Shiha NA, Mohamed SS, Ibrahim WW. SIRT1/PARP-1/NLRP3 cascade as a potential target for niacin neuroprotective effect in lipopolysaccharide-induced depressive-like behavior in mice. Int Immunopharmacol. 2023;123:110720. doi:10.1016/j.intimp.2023.110720
- Ishida M, Sato S, Sato I, Yoshioka A, Uchida N, et al. What can cause cancer patients to attempt suicide? Thiamine deficiency mimicking the symptoms of major depressive disorder. Palliat Support Care. 2024;22:205. doi:10.1017/S1478951523001128
- Lagzi N, Bateni A, Goli R, Talebiazar N. The effect of multivitamins on anxiety and depression in patients undergoing methadone maintenance treatment: A double-blind randomized controlled trial. Int J Psychiatry Med. 2023;58:576. doi:10.1177/00912174231179320
- Tuo LJ, Song XY, Zhu YY, He HN, Song YP, et al. Gestational folic acid supplement prevents vitamin D deficiency-induced depression-like behavior by reversing cortical DNA hypomethylation in adult offspring. J Steroid Biochem Mol Biol. 2023;231:106313. doi:10.1016/j.jsbmb.2023.106313
- Pan LA, Segreti AM, Wrobleski J, Shaw A, Hyland K, et al. Metabolomic disorders: confirmed presence of potentially treatable abnormalities in patients with treatment refractory depression and suicidal behavior. Psychol Med. 2023;53:6046. doi:10.1017/S0033291722003233
