Products best matching Depression

Turmeric Curcumin

8
Nanocurcumin shows antidepressant potential
We explored how nanocurcumin, a form of curcumin extracted from turmeric, influences depressive-like behaviors in rats subjected to chronic stress. Our research included 30 adult male rats, which were split into six groups to examine the effects of three different doses of nanocurcumin alongside a control group and a fluoxetine treatment group.

Before subjecting these rats to an unexpected chronic mild stress scenario, we measured their initial responses to a sweetened water consumption test to assess their baseline mood. Over the following days, we conducted thorough behavioral assessments using various tests designed to evaluate depressive symptoms, such as the open field test and the forced swimming test.

Ultimately, our findings revealed that nanocurcumin significantly improved moods in stressed rats by enhancing serotonin and brain-derived neurotrophic factor (BDNF) levels in their blood. This suggests that nanocurcumin may serve as an effective and promising alternative treatment option for major depressive disorder.
9.5
Fights depression effectively
Most Useful Review
Curcumin demonstrates powerful antioxidant properties that enhance heart health and may aid in preventing cancer. It also helps combat depression by blocking inflammatory signals. It has proven effective compared to some anti-inflammatory drugs in certain studies.

Vitamin B Complex

9
Vitamin B may alleviate depression symptoms
Our investigation looked into how Vitamin B affects behavior and neurotransmitter levels in rats undergoing stress-induced depression.

We set up three groups: a control group, a stressed group, and a stressed group receiving Vitamin B.

The results showed that Vitamin B improved neurotransmitter levels and reduced anxiety and depression-like behaviors in the rats. This suggests that Vitamin B could be beneficial in improving symptoms of depression driven by stress.
9.5
Mood improvement
Most Useful Review
The whole B-complex is contained in one capsule. I have noticed real results: Despite dreary, rainy weather, I feel cheerful. This year, the usual autumn depression has not affected me. I respond calmly to work stress, viewing it as part of life. My skin is managing well through the autumn-winter transition, free from dryness and tightness. My joints are also not causing issues.

Zinc

We investigated the potential benefits of a novel zinc complex, specifically Zn(ALC)Cl(HO), for its effectiveness in treating depression. This innovative compound combines zinc with acetyl-l-carnitine, which is known for its role in energy metabolism and protecting brain cells.

Our findings revealed that this zinc complex displays a remarkable 54% improvement in antidepressant activity compared to standard acetyl-l-carnitine. We also observed its ability to reduce pain in tests involving chronic conditions, showing promise in enhancing overall mental and physical health.

Additionally, this compound demonstrated capability to cross the blood-brain barrier, protecting against cell damage from excessive glutamate. We think these results indicate that Zn(ALC)Cl(HO) could be a significant step forward in managing not just depression but also neurodegenerative challenges.
9.5
Improved mood
Most Useful Review
Very effective and easily digestible vitamins. After a month, it became easier to wake up, and the feelings of drowsiness and apathy vanished. My enthusiasm for living and working returned. I recommend this for those often experiencing depression and post-depression recovery.

5 Htp

8
FeO nanoparticles enhance serotonin levels
We explored the potential of FeO nanoparticles to improve serotonin synthesis in the brain, which is crucial for managing depression. These nanoparticles, enhanced with chitosan for better delivery, mimic the activity of the enzyme tryptophan hydroxylase.

In our research, we observed that the FeO@CS treatment reinstated levels of serotonin and 5-hydroxytryptophan in a mouse model of depression. This led to significant improvements in behaviors typical of depressive conditions.

The innovative approach of using nanozymes to reactivate serotonin pathways shows promise in the quest for effective depression treatments.
9.5
Seasonal blues alleviated
Most Useful Review
It effectively helps combat the seasonal blues, relieves depression, and calms shattered nerves.

L Glutathione

7
Hair serum effectively reduces hair loss
We aimed to evaluate how a hair serum featuring natural ingredients, including Silybum marianum, affects women suffering from chronic telogen effluvium (CTE). In a 16-week study with 64 participants, half used the serum while the other half received a control treatment.

We discovered that the serum significantly reduced hair loss and improved overall hair quality. Participants also reported feeling less depressed and embarrassed about their hair loss, suggesting that this treatment positively impacts quality of life for those affected by CTE.
9.5
Essential support
Most Useful Review
Glutathione, a combination of cysteine, glycine, and glutamine, is effective when taken on an empty stomach, especially after covid or during episodes of spring blues and depression. It really supported me, and by the third day, I felt an extraordinary surge of energy throughout my body!

Phosphatidylserine

8
Luteolin modifies brain lipid metabolism
We investigated how luteolin (LUT), a natural flavonoid, may help alleviate late-onset depression (LOD) in older adults. Using advanced metabolomics techniques, we identified significant changes in glycerophospholipid metabolism in the brains of LOD rats treated with LUT. Notably, LUT improved anxiety and depression-like behaviors while enhancing cognitive functions.

The study found that key lipids like phosphatidylserine were significantly affected by LUT, indicating its role in managing depression. Overall, LUT appears to positively influence brain metabolism, offering a potential avenue for treating depression in the elderly.
8.8
Alleviates seasonal depression
Most Useful Review
No soy from Jerow! The phosphatidylserine is sourced from sunflower, which is a significant advantage. It's beneficial for the nervous system, aids in seasonal depression, lowers cortisol levels and enhances cognitive functions like thinking and memory. Overall, all the supplements from Jerow that I ordered here are effective!

B6 Pyridoxine

8
Vitamin B6 linked to depression
We explored the connections between dietary vitamin B6 intake and depression risk in adults, using data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2005 and 2010. Our study analyzed information from nearly 25,000 individuals aged 20 and over to see how the levels of a specific form of vitamin B6, known as pyridoxal 5'-phosphate (PLP), relate to depression.

Our findings reveal that adults who consumed higher amounts of vitamin B6 or had elevated plasma PLP levels were less likely to experience symptoms of depression. Specifically, those in the top quartile for vitamin B6 intake had a significantly lower risk of depression compared to those in the lowest quartile. Similarly, higher PLP levels were associated with a reduced risk.

We noticed a clear trend: as both dietary intake of vitamin B6 and plasma PLP levels increased, the risk of depression decreased. However, it's important to note that while we found these associations, we cannot claim causation based on this study alone. This suggests that a balanced diet rich in vitamin B6 might be beneficial for mental health.

To fully understand the role of vitamin B6 in treating depression, we believe future randomized controlled trials should explore the potential effects of vitamin B6 supplementation.
9.5
Cognition and mood improvement
Most Useful Review
This product comes in an active form, and I take it with methyl folate and methyl cobalamin to improve my cognitive function and alleviate symptoms of depression. The results have been exceptional.

Iron

7
Exploration of Nutrient Effects
We studied how nutrient supplements, particularly iron, and physical exercise influence depression among older adults in China. Our analysis included 8,427 participants, and we used established tools to measure depression and collect information about their supplement and exercise habits.

Interestingly, we found that 26.2% of the older adults reported suffering from depression. Among the various nutrients studied, we discovered that receiving nutrient supplements, like calcium and multivitamins, was linked to lower depression scores and reduced risk of depression. However, the effects of iron alone could not be isolated due to the combination with other nutrients in the supplements.

Our analysis revealed that physical exercise played a role in mediating the relationship between certain nutrients and depression. This means that for some participants, staying active could enhance the positive effects of nutrient supplementation on their mood. Nevertheless, it is essential to note that there wasn't enough evidence to conclusively state that iron specifically improves depression despite being part of the nutrient mix explored.
8.8
Improved mood
Most Useful Review
I've been using this vitamin for a few months and my overall well-being has noticeably improved. My mood has enhanced, making it an excellent supplement for those who struggle with depression, as it offers varied health benefits, providing good value for money.

L Theanine

We investigated the effects of l-theanine added to sertraline in treating major depressive disorder (MDD). In a six-week, double-blind trial, participants took either l-theanine or a placebo alongside their medication. Results showed that those receiving l-theanine experienced a greater reduction in depression symptoms and higher remission rates compared to the placebo group. Though the study had a small sample size, the findings suggest l-theanine may be a promising adjunct therapy for improving treatment outcomes in MDD. More extensive research is needed for confirmation.
10
Alleviated anxiety
Most Useful Review
I developed anxiety and depression, leading to unclear thoughts and emotional eating. This supplement transformed my well-being. I now feel like my old self, with reduced anxiety and improved focus, enabling me to manage stress calmly. It has significantly improved my sleep and overall mood.

Selenium

8
PHDI linked to reduced depression
We studied the connection between adherence to the Planetary Health Diet Index (PHDI) and depression using data from the National Health and Nutrition Examination Survey. Our analysis revealed a strong negative correlation between higher PHDI scores and the likelihood of experiencing depression.

Specifically, individuals in the highest quartile of PHDI showed significantly reduced depression risks. Vitamins and nutrients like Vitamin C, Fiber, and Selenium played notable roles in this relationship. Essentially, the data suggests that a diet aligned with sustainable practices may help protect mental health.
9.5
Significant improvement
Most Useful Review
This product has been a life changer for me. I felt a great deal of fatigue and depression. Now, I've never been in better shape in my life and have lost 14 pounds. I've been eating healthier and exercising more than ever before, and this vitamin has helped me return to my healthiest self without any supplements.

Magnesium

7
Magnesium complex shows antidepressant promise
We explored the antidepressant effects of a new imipramine-magnesium (IMI-Mg) complex in male mice. Using established behavioral tests like the forced swim and tail suspension tests, we found that this complex notably reduced immobility time, indicating potential antidepressant-like activity.

Importantly, the results were comparable to administering imipramine and magnesium individually. This promising finding suggests the IMI-Mg complex could pave the way for enhanced treatment approaches, improving safety and patient adherence in depression therapies.
9.5
Improved well-being
Most Useful Review
I had been experiencing constant sleepiness, headaches, irritability, and depression before starting magnesium. Using Magnesium Caps has helped me assimilate essential vitamins and minerals, thin my blood, and synthesise the hormone of joy. It effectively alleviated insomnia and my migraines, apathy and depression have vanished. I now feel refreshed after six hours of sleep and my mental clarity has improved significantly. I highly recommend it, especially when taken before bedtime!

N Acetyl Cysteine Nac

8
PHDI linked to reduced depression
We studied the connection between adherence to the Planetary Health Diet Index (PHDI) and depression using data from the National Health and Nutrition Examination Survey. Our analysis revealed a strong negative correlation between higher PHDI scores and the likelihood of experiencing depression.

Specifically, individuals in the highest quartile of PHDI showed significantly reduced depression risks. Vitamins and nutrients like Vitamin C, Fiber, and Selenium played notable roles in this relationship. Essentially, the data suggests that a diet aligned with sustainable practices may help protect mental health.
10
Life-changing experience
Most Useful Review
For me, NAC has been life-changing! It effectively alleviates ruminations that lead to depression and OCD. A low dose of 600 mg each morning works wonders.

Coenzyme Q10 Coq10

9
Q10 enhances mood in Alzheimer’s
We explored the potential of coenzyme Q10 (Q10) in tackling mental and memory issues often faced by patients with Alzheimer's disease (AD). The study took a closer look at whether low-intensity pulsed ultrasound (LIPUS) could help in delivering a specially prepared 30 nm form of Q10 across the blood-brain barrier more effectively.

Through this research, we administered 30 nm Q10 to both wild-type mice and genetically modified APP/PS1 mice that model familial AD. We examined the effects of Q10 alone and in combination with LIPUS at two different intensities (50 and 100 mW/cm). What we discovered was intriguing: combining the higher intensity of LIPUS with 30 nm Q10 not only improved mood and reduced anxiety and depressive behaviors but also led to an increase in essential brain chemicals like serotonin and dopamine, while lowering harmful substances like formaldehyde.

However, it's important to note that even with these promising results, LIPUS alone did not completely eliminate symptoms of anxiety, depression, or memory deficits. While the combination therapy showed effectiveness in enhancing Q10 delivery and boosting some mood-related markers, further research is needed to refine these treatments for better overall outcomes in Alzheimer’s.
9
Supports depression relief
Most Useful Review
Coenzyme Q10 is vital for energy production and has notably improved my well-being. After noticing its benefits, including reduced fatigue and enhanced mood, I’ve encouraged others to try it. My mother, who leads an unhealthy lifestyle, experienced a significant uplift in her energy levels and mood after taking it. It's an essential support for heart health and an effective remedy for depression.

Vitamin D

8
Fortified yogurt benefits depression treatment
We conducted a double-blind randomized controlled trial to explore how a specially fortified yogurt affects depression and sleep quality in women with polycystic ovary syndrome (PCOS). This study involved two groups of participants: one group consumed yogurt enriched with probiotics, vitamin E, and vitamin D, while the other group received a placebo.

After eight weeks of monitoring, we observed a significant improvement in depression levels among those who enjoyed the fortified yogurt compared to the placebo group. This suggests that the combined intake of probiotics, along with vitamins, may help alleviate depressive symptoms in women suffering from PCOS. However, when it comes to sleep quality, the results didn’t show any noticeable improvement, indicating that while certain nutritional interventions can positively affect mood, they may not necessarily enhance sleep.

Overall, our findings point to the potential benefits of nutritional approaches in managing depression, particularly for individuals who may prefer alternatives to traditional antidepressant medications. However, we should remain cautious, as further research is needed to fully understand the individual effects of each component, especially vitamin D, on mental health.
9.5
Boosted immunity
Most Useful Review
Good afternoon! These Vitamin D3 capsules are fantastic for boosting immunity in a digestible liquid form. Living in Siberia, we suffer from vitamin D deficiency. We've noticed a positive effect during the ARVI season, as we fell ill less frequently and more mildly. The whole family takes it, and I’ve been on this dosage for over a year. It helps alleviate depression due to the lack of sun, increases vitality, and without it in the morning, I don't feel like myself.

Vitamins

9.5
Cholecalciferol eases depression symptoms
We conducted a thorough exploration of how vitamin D3, or cholecalciferol, affects depressive symptoms in patients with type 2 diabetes mellitus (T2DM). This double-blind, randomized, placebo-controlled trial involved 70 participants who experienced both T2DM and depression. For 12 weeks, one group received a daily dose of 4000 IU of cholecalciferol, while the other group received a placebo.

By assessing depression levels using the Beck Depression Inventory-II before and after the study, we observed notable results. Not only did the cholecalciferol group report a significant reduction in depression scores, but we found a marked increase in C-peptide levels as well, which may be linked to improvements in mood.

However, we did not find significant changes in serotonin and neurotrophin-3 levels between the two groups, leaving us with some unanswered questions about these mechanisms. Overall, our findings suggest that supplementing with cholecalciferol could potentially relieve mild to moderate depressive symptoms for people managing T2DM, especially through enhanced C-peptide levels.
9.5
Effective for depression
Most Useful Review
They have a distinct lemon colour and shape, roughly 1 cm in length. The smaller grains are easy to swallow without risk of choking. Since I've been taking this with magnesium, I've noticed minimal effects from Mother of Life, but it has been beneficial for my depression and frustration. I feel generally more comfortable each day without the ups and downs.

Probiotics

8
Probiotic yogurt alleviates depression
We explored the effects of fortified yogurt on women with polycystic ovary syndrome (PCOS) over an 8-week period. In this randomized, double-blind study, one group enjoyed yogurt enriched with probiotics, vitamin E, and vitamin D, while the other had a standard yogurt placebo.

Participants in the yogurt group showed significant improvement in depression levels compared to the placebo group, though no gains were noted in sleep quality. This suggests that incorporating probiotics in dietary interventions may help manage depression in PCOS patients, serving as an alternative for those hesitant to use traditional antidepressants. However, we recognize the need for further research to solidify these findings.
8.8
Effective for depression
Most Useful Review
I am satisfied with these probiotics, which support emotional well-being. They contain strains that help calm feelings, relieve stress, and promote relaxation. I previously took a different brand last winter but found similar strains. This product particularly enhanced my mood, which was crucial given my seasonal depression. I noticed substantial improvement in my feelings, likely due to the probiotic strains used, rather than just an ingredient like Ash, which I consumed separately. Unlike my previous product, this one doesn't compromise mood support. It even contains acacia fibre, beneficial for gut health, and I plan to repurchase.

Calcium

7
Calcium's role in depression explored
We aimed to investigate the connection between calcium levels and depression, specifically comparing unipolar and bipolar disorders. In the course of our pilot study, we enrolled 36 patients admitted to the University of Insubria Psychiatric Unit, who completed various psychological assessments to gauge their mental health.

Our findings revealed a noteworthy association between calcium levels and bipolar depression. We observed significant correlations not only between calcium and depressive symptoms, but also with inflammation markers like CRP (C-reactive protein). This indicates a possible relationship where lower calcium levels may relate to more severe symptoms in individuals with bipolar disorder.

While these associations are intriguing, it's important to note that we did not isolate the effects of calcium treatment itself on depressive symptoms. Therefore, while our results push the conversation forward regarding the role of calcium in mental health, they do not establish that calcium treatment is definitively beneficial for those struggling with depression.

Further research is essential to deepen our understanding of how inflammatory markers like calcium may contribute to different forms of depression. Our study highlights a pathway for future exploration into targeted therapeutic strategies that could help in treating these complex mood disorders more effectively.
9.5
Greater well-being achieved
Most Useful Review
Wonderful! This is like a dream. All signs of depression and fatigue are gone. I take it at night every day, and I feel fantastic.

B12

8
Vitamin B shows potential in depression
We looked into how Vitamin B could change behaviors and brain chemistry in rats experiencing depression-like symptoms. Rats were split into groups to compare a control group, one exposed to chronic mild stress, and a group receiving Vitamin B injections.

Results showed that Vitamin B helped boost levels of key neurotransmitters associated with mood, reducing anxiety and depressive behaviors. It also positively impacted brain cell health by activating important signaling pathways.

Overall, Vitamin B appears promising in helping to combat depression-related issues in this rat model.
10
Depression alleviated
Most Useful Review
A beautiful product! To be brief, my depression has passed, and I have experienced less hair loss.

Folic Acid

We investigated how effective combining low-dose methylfolate with standard antidepressants is for treating depressive disorder.

In an open-label trial involving 44 patients, one group received traditional antidepressants while the other received the same medications along with methylfolate for four weeks.

We found that this combination therapy could be a safe and effective approach, potentially improving patient outcomes.
8.8
Better well-being
Most Useful Review
I take folic acid to combat my depression. My well-being and mood have steadily improved. I appreciate the results, especially as I had previously lost hope that anything would help me.

Omega 3 Fish Oil

7
Omega-3 shows potential for depression
We set out to understand how omega-3 fish oil and other anti-inflammatory treatments affect depression in older adults. This comprehensive review analyzed 31 randomized controlled trials to see if these interventions could reduce depressive symptoms. The findings showed that older adults had a moderate decrease in depression scores, particularly benefiting from omega-3 treatments. While this suggests a positive impact, it's important to note the studies had some variability in results. This calls for more focused research to pinpoint the best treatments for depression in this age group.
9.5
Mood improvement
Most Useful Review
I have tried numerous omega brands and this one is by far my favourite. If you take 2 capsules daily, it lasts two months, which is quite economical. I experience a light citrus burp instead of fishy, which is a plus. It has improved my hair and nails and helped my post-Covid depression significantly. The packaging is excellent and the capsules, though large and straw-yellow, are easy to swallow. Drinking omega is advisable for everyone, as it truly enhances health and mood.

Pre Post Natal Formulas

9.5
Cholecalciferol eases depression symptoms
We conducted a thorough exploration of how vitamin D3, or cholecalciferol, affects depressive symptoms in patients with type 2 diabetes mellitus (T2DM). This double-blind, randomized, placebo-controlled trial involved 70 participants who experienced both T2DM and depression. For 12 weeks, one group received a daily dose of 4000 IU of cholecalciferol, while the other group received a placebo.

By assessing depression levels using the Beck Depression Inventory-II before and after the study, we observed notable results. Not only did the cholecalciferol group report a significant reduction in depression scores, but we found a marked increase in C-peptide levels as well, which may be linked to improvements in mood.

However, we did not find significant changes in serotonin and neurotrophin-3 levels between the two groups, leaving us with some unanswered questions about these mechanisms. Overall, our findings suggest that supplementing with cholecalciferol could potentially relieve mild to moderate depressive symptoms for people managing T2DM, especially through enhanced C-peptide levels.
9.5
Depression prevention
Most Useful Review
Excellent prenatal vitamins! Omega-3 plays a crucial role in pregnancy, helping to reduce the risk of late toxicity and depression. Nordic Naturals is entirely safe, with independent testing confirming high safety standards. Their production process eliminates heavy metals and dioxins, ensuring quality. The capsules have a pleasant taste and don't cause belching, which is common with many fish oils.

Inositol

8
Inositol's role in depression unclear
We explored the role of inositol in alleviating depression among children and adolescents. This systematic review gathered data from nine studies involving 561 participants, focusing on the effectiveness of omega-3 fatty acids alongside inositol in combating depressive symptoms.

Our analysis found that while inositol is often included with omega-3 in combination therapies, its isolated effect on depression could not be clearly established. The results indicated that when omega-3 is combined with inositol, it showed promising efficacy, acting as a potential support for traditional therapies.

However, we noted that there was no significant improvement in depression symptoms compared to placebo treatments when evaluating these interventions individually. Ultimately, omega-3 paired with psychoeducational psychotherapy emerged as the most effective approach, but the impact of inositol on its own remains inconclusive.

These findings suggest a need for future studies to assess inositol individually, helping us better understand its potential in managing depression.
9.5
Reduced panic
Most Useful Review
I have struggled with depression and panic disorder, relying on prescribed medication. After starting Inositol, I was pleasantly surprised by its calming effects; I found myself able to go without my usual medications for the first time in ages. I remain cautious, yet hopeful for further progress.

Dha

5
Investigating DHA’s depression treatment
We explored the effectiveness of omega-3 polyunsaturated fatty acids (PUFAs), particularly docosahexaenoic acid (DHA), in treating depression through a meta-analysis of randomized controlled trials. Our investigation included extensive data from 36 studies, offering a comprehensive look at how these fatty acids might influence mental health.

While we found some significant evidence suggesting that omega-3 PUFAs, in general, could be beneficial for people suffering from depression, the specific impact of DHA alone was not isolated. It turned out that there's no stronger effect from omega-3 PUFAs compared to a placebo in terms of response rates, remission, or adverse events. Interestingly, we noted that patients from Asia who experienced mild to moderate depression and took DHA over a period of eight weeks might fare the best if their daily dosage ranged from 1000 to 1500 mg, maintaining a specific ratio of eicosapentaenoic acid (EPA) to DHA.

Overall, we observed that while omega-3s may provide some benefits in treating depression, they do not show superior results compared to a placebo group. This highlights the importance of understanding not just the broader category of omega-3s, but the nuanced roles of individual components like DHA.
9.5
Improved memory function
Most Useful Review
Breaking old habits can be challenging, especially when it comes to diet. My upbringing led to a lack of Omega-3, which resulted in poor memory and cognitive function. After incorporating DHA into my routine, my memory improved significantly, and I felt more alert. It also positively influenced my skin and hair. I intend to continue supplementing with DHA, especially due to its link to combating depression.

Ashwagandha

5
Investigating DHA’s depression treatment
We explored the effectiveness of omega-3 polyunsaturated fatty acids (PUFAs), particularly docosahexaenoic acid (DHA), in treating depression through a meta-analysis of randomized controlled trials. Our investigation included extensive data from 36 studies, offering a comprehensive look at how these fatty acids might influence mental health.

While we found some significant evidence suggesting that omega-3 PUFAs, in general, could be beneficial for people suffering from depression, the specific impact of DHA alone was not isolated. It turned out that there's no stronger effect from omega-3 PUFAs compared to a placebo in terms of response rates, remission, or adverse events. Interestingly, we noted that patients from Asia who experienced mild to moderate depression and took DHA over a period of eight weeks might fare the best if their daily dosage ranged from 1000 to 1500 mg, maintaining a specific ratio of eicosapentaenoic acid (EPA) to DHA.

Overall, we observed that while omega-3s may provide some benefits in treating depression, they do not show superior results compared to a placebo group. This highlights the importance of understanding not just the broader category of omega-3s, but the nuanced roles of individual components like DHA.
9.5
Increased energy
Most Useful Review
I was amazed by my personal results. After a week of taking one caplet daily, my energy level noticeably increased, and my long-standing low-grade depression vanished. Research showed it balanced my hormones, and my daughter also experienced emotional stability. I'm 56 and lead a very healthy lifestyle.

B3 Niacin

8
Inositol's role in depression unclear
We explored the role of inositol in alleviating depression among children and adolescents. This systematic review gathered data from nine studies involving 561 participants, focusing on the effectiveness of omega-3 fatty acids alongside inositol in combating depressive symptoms.

Our analysis found that while inositol is often included with omega-3 in combination therapies, its isolated effect on depression could not be clearly established. The results indicated that when omega-3 is combined with inositol, it showed promising efficacy, acting as a potential support for traditional therapies.

However, we noted that there was no significant improvement in depression symptoms compared to placebo treatments when evaluating these interventions individually. Ultimately, omega-3 paired with psychoeducational psychotherapy emerged as the most effective approach, but the impact of inositol on its own remains inconclusive.

These findings suggest a need for future studies to assess inositol individually, helping us better understand its potential in managing depression.
8.8
Effective treatment
Most Useful Review
It's great for managing depression, and being flush-free makes it even more comfortable to take.

Vitamin B

7
Depression linked to low folate
We explored how different levels of depressive symptoms could influence folate levels in the body, focusing on findings from the NHANES database collected between 2017 and 2020. Our analysis involved nearly 5,000 participants and examined their serum and erythrocyte folate levels in relation to the severity of their depressive symptoms.

Through linear regression models and logistic regression validation, we observed a clear connection between depression and reduced folate levels. Individuals with moderate depression were found to have significantly lower serum folate levels, while those with major depression showed decreased erythrocyte folate levels.

This highlights an important aspect of managing depression; we need to pay attention to the nutritional intake of those affected. As these patients often struggle with dietary habits, providing folic acid supplements could be valuable, particularly for those experiencing moderate to severe depression. This approach may contribute positively to their overall mental health care.
8.8
Fights depression effectively
Most Useful Review
EXCELLENT RESULT! If you consume little fresh greens and spinach, this supplement is essential. The folic acid here is vital for women’s health, supporting all organs, revitalising the cardiovascular system, and aiding in youthfulness. Vitamin B12, combined with folic acid, is effective against depression, fatigue, and irritability. These vitamins are interconnected, so it's best to take them together. I highly recommend this product! Thank you very much for your recommendation!

Sports Fish Oil Omegas

4
EPA shows potential in depression
We examined the effectiveness of eicosapentaenoic acid (EPA), a type of omega-3 polyunsaturated fatty acid, in treating depression. After analyzing 36 well-structured studies, we found some positive outcomes and also observed notable variability in the results. The overall findings suggested that EPA could offer benefits for depression, yielding a small but statistically significant improvement in symptoms.

It's particularly interesting to note that for Asian patients experiencing mild to moderate depression, the best results seemed to emerge with a daily dosage of 1000 to 1500 mg of omega-3s over eight weeks. This intake should ideally have a specific balance of EPA to another omega-3, docosahexaenoic acid (DHA), set at between 1:1 and 2:1 ratios. However, despite these encouraging indications, our analysis also revealed that EPA isn’t better than a placebo for achieving response or remission rates or for adverse events.

Overall, while omega-3 PUFAs like EPA may hold promise for managing depressive symptoms, we must approach the findings with caution. Further research is warranted to deepen our understanding of how to harness the potential benefits of these fatty acids in treating depression.
8.8
Supports depression relief
Most Useful Review
Distinguished Reduces the risk of depression and anxiety, enhancing brain function significantly for concentration and memory. Omega 3 also promotes healthy skin and hair. These pills help reduce appetite during main meals, aiding weight loss likely through regulating serotonin, the hormone that controls appetite. This control can significantly reduce depression symptoms. Quality ingredients and excellent taste.

Vitamin Bs

8
Inositol's role in depression unclear
We explored the role of inositol in alleviating depression among children and adolescents. This systematic review gathered data from nine studies involving 561 participants, focusing on the effectiveness of omega-3 fatty acids alongside inositol in combating depressive symptoms.

Our analysis found that while inositol is often included with omega-3 in combination therapies, its isolated effect on depression could not be clearly established. The results indicated that when omega-3 is combined with inositol, it showed promising efficacy, acting as a potential support for traditional therapies.

However, we noted that there was no significant improvement in depression symptoms compared to placebo treatments when evaluating these interventions individually. Ultimately, omega-3 paired with psychoeducational psychotherapy emerged as the most effective approach, but the impact of inositol on its own remains inconclusive.

These findings suggest a need for future studies to assess inositol individually, helping us better understand its potential in managing depression.
9.5
Enhanced mood
Most Useful Review
I've taken this vitamin for several months now, and it has been excellent. I take it daily to maintain my health, and I've seen improvements not only in my immunity but also in my mood, which is fantastic given my battle with depression.

Calcium Magnesium

9.5
Cholecalciferol eases depression symptoms
We conducted a thorough exploration of how vitamin D3, or cholecalciferol, affects depressive symptoms in patients with type 2 diabetes mellitus (T2DM). This double-blind, randomized, placebo-controlled trial involved 70 participants who experienced both T2DM and depression. For 12 weeks, one group received a daily dose of 4000 IU of cholecalciferol, while the other group received a placebo.

By assessing depression levels using the Beck Depression Inventory-II before and after the study, we observed notable results. Not only did the cholecalciferol group report a significant reduction in depression scores, but we found a marked increase in C-peptide levels as well, which may be linked to improvements in mood.

However, we did not find significant changes in serotonin and neurotrophin-3 levels between the two groups, leaving us with some unanswered questions about these mechanisms. Overall, our findings suggest that supplementing with cholecalciferol could potentially relieve mild to moderate depressive symptoms for people managing T2DM, especially through enhanced C-peptide levels.
9.5
Calmness achieved
Most Useful Review
Calm improved! I began to feel much calmer, with no signs of depression. My husband is surprised by my reduced yelling. I highly recommend it.

Multivitamins

9.5
Improved wellbeing
Most Useful Review
Excellent! My overall health has improved, I now have more stamina and feel much more energised. I no longer experience mood swings or depression. This supplement is easy to take, and I recommend it to anyone seeking a natural way to enhance their health.
10
Improved mood and calmness
Most Useful Review
Believe me, this is a miracle! I had long-term postpartum depression for five years, raising three children without help. These capsules have truly made a significant difference! I took two in the morning after breakfast and another in the afternoon. There are absolutely no withdrawal symptoms! I feel revitalised and healthy! Stress no longer bothers me, and I'm calm, balanced, and collected. I've stopped shouting at the children and now dance and laugh with them. My husband and I aren't arguing anymore! Give it a try; you might love it too!

St Johns Wort

10
No more anxiety
Most Useful Review
No More Depression or Anxiety attacks! My family has a strong history of depression, and I began to notice signs in myself around age 35. My doctor prescribed various medications, but they didn’t work well and caused severe anxiety attacks. After reading about St. John’s Wort's success in Europe, I decided to try it. I stopped all prescriptions and have been using St. John’s Wort for 15 years now. I am free from depression and anxiety attacks, feeling quite mellow instead. I take 2 in the morning and 1 at noon. I’m very pleased with the quality and price of the Now Foods brand.
8.8
Calmer and brighter
Most Useful Review
I did not expect such an effective result. I feel calmer, and my sleep has improved significantly. The depression has largely disappeared. After two weeks, I forgot to take it regularly, as I had developed interests and energy I had lacked before. Now, I only take it occasionally when my nerves act up.

Melatonin

10
Eliminated bad moods
Most Useful Review
This is the best vitamin I’ve ever tried. It has helped me overcome my bad moods and manage my depression. I will never switch to any other vitamin again.
9.5
Menopause relief
Most Useful Review
Melatonin saved me from insomnia caused by menopause. Despite being terrified of potential side effects, I tried it and found it effective. One hour before sleep, I feel drowsy and able to fall asleep easily after struggling for ages. Initially, I used it every two days, but after a month, I could sleep without it. It feels like a memory inside my body.

Fiber

8.8
Calming effects
Most Useful Review
I bought this for a girl who was experiencing a mild autumn depression. After a few days of use, she found that she was coping better with stress and felt much calmer overall. Her muscles relaxed, and her immune system seemed to be recovering. Importantly, she did not experience any side effects.
9.5
Mood improvement
Most Useful Review
I have tried numerous omega brands and this one is by far my favourite. If you take 2 capsules daily, it lasts two months, which is quite economical. I experience a light citrus burp instead of fishy, which is a plus. It has improved my hair and nails and helped my post-Covid depression significantly. The packaging is excellent and the capsules, though large and straw-yellow, are easy to swallow. Drinking omega is advisable for everyone, as it truly enhances health and mood.

Acetyl L Carnitine

9.5
Mind clarity boost
Most Useful Review
Great product! I take it thrice daily, and it sharpens my mind, improves memory, and I opted for this natural solution rather than becoming reliant on pills for depression. It truly works!
9.5
Menopause relief
Most Useful Review
After about two weeks of taking Acetyl L-Carnitine, my depression, anxiety, and irritability linked to menopause disappeared, allowing me to spend my days calmly as if clouds had cleared.

L Carnosine

9.5
Depression relief
Most Useful Review
It works for depression! My depression has significantly reduced since I started taking it. The synergistic effect of combining it with supplements like B vitamins, vitamin C, vitamin E, and niacin has proven beneficial.
8.8
Mental enhancement
Most Useful Review
I find L-Carnosine to be an excellent dietary supplement and a powerful antioxidant, especially for those over 40. It lowers blood sugar, blood pressure, and enhances cardiovascular health. Furthermore, it boosts brain function and helps those experiencing chronic fatigue and depression. The product’s quality, packaging, and prompt delivery are commendable.

Ginkgo Biloba

9.5
Panic reduction
Most Useful Review
Alongside "Gotu Kola," I've seen remarkable effects! My weight issues and memory lapses have resolved. My brother, who had severe anxiety and depression, experienced a remarkable recovery over two months, resulting in a stable state for six months after stopping medication. These supplements are truly miraculous!
9.5
Supports mental health
Most Useful Review
Vitamin For The Brain: Aging processes are irreversible, and in large cities, under conditions of unfavourable ecology, chronic stress, and fatigue, the first age-related symptoms appear at a young age. Ginkgo extract helps stimulate blood vessel expansion, reduce pressure and strokes, lower cholesterol levels, and improve brain health, aiding in symptoms of depression and enhancing overall cognitive function.

Spirulina

9.5
Alleviated spring depression
Most Useful Review
I was pleasantly surprised by the effectiveness! After taking spirulina with Vitamin D, I felt lighter, my skin improved, and I experienced a superb mood, without the dreadful spring depression caused by vitamin deficiency. While others were sluggish at work, I felt cheerful. I will continue taking spirulina regularly!
9.5
Disappeared depression
Most Useful Review
An amazing product! I initially bought it for my father, who has type 2 diabetes. By the third day, I noticed improvements with his strength and mood, almost as if depression vanished. After a week, he no longer needed blood pressure medication, and his sugar levels normalised. I regretted trying another brand, as it couldn’t compare to this product’s effects.

Ubiquinol Coq10

8.8
Supports heart health
Most Useful Review
Excellent antioxidant, improves heart and nervous system function. Ubiquinol, an enhanced form of coenzyme Q10, supports the cardiovascular system, acts as an antioxidant, and boosts the immune system. It's beneficial for the nervous system, heart, and brain, and helps prevent depression while increasing resistance to stress. The capsules are small. I sincerely recommend it.
9.5
Mood improvement
Most Useful Review
This drug is my salvation as it prevents depression and improves my mood. Mitochondria, which suffer from stress, benefit greatly from it. The capsules are small and have a neutral taste.

L Lysine

8.8
Mood improvement
Most Useful Review
Lysine is an essential amino acid that must be obtained from food or supplements. It aids athletes in muscle recovery, supports skin and hair health, and helps those prone to depression. It also assists the elderly in preventing osteoporosis and those suffering from herpes in mitigating symptoms.
9.5
Cold sore assistance
Most Useful Review
Lysine improves calcium absorption, restoring the body's normal state. It effectively relieves anxiety syndrome and alleviates depression harmlessly. Additionally, it is helpful for cold sores.

Potassium

9.5
Muscle pain relief
Most Useful Review
I found relief from muscle pain, fatigue, and depression after trying potassium. It helps maintain heart health, reduces the risk of stroke, and supports bones and muscles, amongst other benefits.
8.8
Postpartum relief
Most Useful Review
I recommend all mothers to use this after giving birth. The girls of Chavani often struggle with postpartum depression, and this helps restore their short-term memory, which can be lost due to depression. I advise combining copper, sodium, 10,000 IU vitamin D by Solgar, a vitamin B complex, magnesium, and Omega-rich supplements to alleviate anxiety and depression.

Lactoferrin

9.5
Boosted immunity noted
Most Useful Review
It increases immunity and aids iron absorption. I take it alongside iron supplementation, and my ferritin levels have already risen. My health has improved notably: my depression has lessened, sleeps better now, and my brain feels active again! Additionally, I've noticed an enhancement in my immunity!
8.8
Improved sleep quality
Most Useful Review
This supplement appears to help with overall well-being. Taking one to three tablets before bed seems to have improved various aspects of my health, including sleep, rhinitis, acne, bowel movement, and depression, all without side effects. I believe it offers the best balance of benefits and risks.

Childrens Herbs

9.5
Essential for children
Most Useful Review
Echinacea is a vital addition to any medicine cabinet, especially for children. Its natural ingredients and sweet orange flavour appeal to kids while effectively strengthening their immune systems. This gentle stimulant is essential during cold seasons and helps them recover more swiftly from illnesses, including cases of depression.
9
Immunity booster
Most Useful Review
Echinacea is a potent natural immunity booster and is effective in treating and preventing respiratory diseases and depression. It aids in alleviating fatigue and supports the body during recovery periods, while also being beneficial in complex therapies for various ailments, including skin pathologies. Echinacea is especially useful for children to strengthen their immune systems, particularly those attending school.

Alpha Lipoic Acid

9.5
Spring depression improved
Most Useful Review
Indispensable product! Spring depression was not an issue for me any longer, thanks to this.
9.5
Depression alleviated
Most Useful Review
This product significantly improves my depression when I take it.

Dhea

8.8
Reduces depression
Most Useful Review
Needed for those who lack adrenal hormone to maintain hormonal balance. There is a noticeable effect, as it reduces depression and also improves hair quality. I highly recommend it!
9.5
Improves concentration
Most Useful Review
It has helped me cope with depression and has greatly improved my concentration. I struggled with numerous intrusive thoughts, but now my condition has significantly improved.

B1

8.8
Fatigue relief
Most Useful Review
Excellent! Over the past six months, I struggled with constant fatigue; getting out of bed felt impossible! I suffered from headaches and relentless depression. On my doctor’s advice, I began taking B vitamins, specifically B1 and B6, along with magnesium and D3. I chose the Solgar brand because I trust its quality.
9.5
Effective for anxiety
Most Useful Review
Thiamine — or vitamin B1 — is surprisingly effective for anxiety and depression. Often called the “anti-stress” vitamin, low blood thiamine levels are linked with generalized anxiety disorder. I take one tablet daily with no adverse side effects.

Garlic

8.8
Boosted serotonin production
Most Useful Review
Garlic extract possesses anti-inflammatory and bactericidal properties. The supplement bolsters the immune system and helps to normalise metabolism. Positive effects include improved blood oxygen saturation and detoxification of harmful substances. Moreover, it safeguards the liver from chemicals and medications, boosts antibody production to combat viruses, restores intestinal microflora, and enhances men's potency. It also combats fungi, aids insulin production in diabetes, clears respiratory sputum, prevents heart and vascular diseases, regulates lipid balance, and aids weight management. Notably, it promotes serotonin production, enabling one to better cope with depression. I found it beneficial.
9.5
Effective stress relief
Most Useful Review
Garlic effectively reduces stress and anxiety while aiding in coping with depression. It promotes serotonin production as well. I was recommended garlic extract for detox, and one jar was sufficient for three courses! I'm a loyal customer of this brand, which offers a variety tailored to one's needs.

Peppermint Oil

9.5
Relaxes depression
Most Useful Review
Excellent! The scent of refreshing drowsiness relieves my depression and makes me noticeably relaxed.
8.8
Soothes depression
Most Useful Review
Very good! This peppermint essential oil with lemon essential oil has a fresh aroma and feels wonderful to use, alleviating my depression and improving my mood. Natural ingredients are always preferable to medicines, catering better to the needs of both body and mind for users of any age.

Resveratrol

7.5
Improves brain activity
Most Useful Review
I purchased this for my sister following her illness. Since using it, she has felt a surge of energy and cheerfulness. Resveratrol slows cellular aging, protects against depression, enhances cerebral blood flow, and improves memory.
9.5
Helps brain injury
Most Useful Review
I appreciate that this brand crosses the blood-brain barrier. Resveratrol benefits my brain injury, anxiety, depression, and energy levels significantly.

Alpha Gpc

9
Improved mood
Most Useful Review
As usual, it’s great. I’ve been taking it for a while and can see the effects; it surprisingly helped lift me out of depression.
8.8
Eases symptoms
Most Useful Review
The bioavailable form of choline constitutes an essential part of brain cell and nerve tissue membranes, penetrating the blood-brain barrier. It reduces symptoms of depression and anxiety, while inhibiting dementia development and improving muscle strength.

Evening Primrose Oil

9.5
Eliminated PMS symptoms
Most Useful Review
The add-on worked exceptionally well. My wife used it for two months, alleviating her PMS symptoms: depression, irritability, and abdominal pain. The quality is excellent, with a neutral taste and glass jar packaging. Although the tablets are large, they are easy to swallow. I highly recommend it!
8.8
Reduced PMS symptoms
Most Useful Review
I struggled with severe PMS symptoms but wished to avoid hormonal contraceptives. After taking two pills a day, I transitioned from suffering two weeks of debilitating cramps to only a couple of days with manageable discomfort. Additionally, irritability, depression, anxiety, and lower back pain linked to my period were significantly alleviated. Highly recommend!