' 
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 4 Reviews
8.5
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Niacin
500 mg
3,125%
Top Medical Research Studies
8
Niacinamide enhances acne treatment
Nicotinic acid/niacinamide and the skin.
Directly relevant to acne treatment
We examined how niacinamide, a form of vitamin B3, impacts acne and similar skin issues. This included looking at its potential to soothe inflammatory conditions like acne and rosacea.
Our findings suggest that niacinamide has several benefits for the skin. It helps strengthen the epidermal barrier, which means it can reduce water loss and keep the skin hydrated. Additionally, niacinamide encourages the production of proteins like keratin and supports the synthesis of important fats known as ceramides.
Not only does niacinamide contribute to healthy skin, but it also works to improve surface texture and diminish the appearance of fine lines as we age. Importantly for acne sufferers, niacinamide shows promise in providing anti-inflammatory effects, making it a potential game-changer for those battling breakouts.
By incorporating niacinamide into skincare routines, individuals may see improvements in acne and overall skin health. Given its wide-ranging benefits, it's worth considering for anyone dealing with skin that is prone to issues.
Our findings suggest that niacinamide has several benefits for the skin. It helps strengthen the epidermal barrier, which means it can reduce water loss and keep the skin hydrated. Additionally, niacinamide encourages the production of proteins like keratin and supports the synthesis of important fats known as ceramides.
Not only does niacinamide contribute to healthy skin, but it also works to improve surface texture and diminish the appearance of fine lines as we age. Importantly for acne sufferers, niacinamide shows promise in providing anti-inflammatory effects, making it a potential game-changer for those battling breakouts.
By incorporating niacinamide into skincare routines, individuals may see improvements in acne and overall skin health. Given its wide-ranging benefits, it's worth considering for anyone dealing with skin that is prone to issues.
Read More
7
Nicotinic acid may control acne
Nicotinic acid suppresses sebaceous lipogenesis of human sebocytes via activating hydroxycarboxylic acid receptor 2 (HCA ).
Relevant to acne treatment options
We investigated how nicotinic acid, also known as niacin, influences sebocytes—cells responsible for producing sebum—in the context of acne treatment. Our research focused on understanding whether niacin could effectively modulate sebaceous lipogenesis, especially in conditions where excess sebum production occurs, as seen in acne.
In our studies using immortalized human sebocyte lines, we found that when used at safe concentrations, niacin did not disrupt normal sebum production. However, it did manage to reduce excessive sebum production triggered by certain lipogenic agents, making it a potential candidate for acne management. Furthermore, we noted that niacin increased calcium signaling within the cells and showed an anti-proliferative effect, suggesting it could help regulate sebocyte activity.
Interestingly, while niacin did not inhibit inflammation caused by lipopolysaccharides, its ability to normalize excessive sebum production is noteworthy. Our findings reveal that sebocytes express hydroxycarboxylic acid receptor 2 (HCA), which seems essential for niacin's action. Silencing this receptor inhibited niacin's effects, indicating a specific pathway through which niacin could exert its influence on sebum production.
Overall, our data suggest that niacin and other HCA activators might serve as promising treatments for controlling acne by suppressing excess sebum formation, potentially offering a safer option for individuals concerned about traditional treatments that can lead to dryness.
In our studies using immortalized human sebocyte lines, we found that when used at safe concentrations, niacin did not disrupt normal sebum production. However, it did manage to reduce excessive sebum production triggered by certain lipogenic agents, making it a potential candidate for acne management. Furthermore, we noted that niacin increased calcium signaling within the cells and showed an anti-proliferative effect, suggesting it could help regulate sebocyte activity.
Interestingly, while niacin did not inhibit inflammation caused by lipopolysaccharides, its ability to normalize excessive sebum production is noteworthy. Our findings reveal that sebocytes express hydroxycarboxylic acid receptor 2 (HCA), which seems essential for niacin's action. Silencing this receptor inhibited niacin's effects, indicating a specific pathway through which niacin could exert its influence on sebum production.
Overall, our data suggest that niacin and other HCA activators might serve as promising treatments for controlling acne by suppressing excess sebum formation, potentially offering a safer option for individuals concerned about traditional treatments that can lead to dryness.
Read More
Most Useful Reviews
10
Significantly clearer
I adore this niacinamide! I experience severe bacne from workouts, and after my dermatologist recommended it, my back cleared significantly in three weeks. My face is also much clearer; I previously had painful cystic acne, but none has emerged with this treatment. I subscribed after forgetting to order it once, leading to a recurrence of my acne. As someone with fair skin, I appreciate any help I can get to prevent skin cancer. Highly recommend!
Read More
9.5
Major improvement
My dermatologist suggested these to help with my acne, and I have seen a significant improvement. There are fewer red areas and less pimples on my face since starting this treatment. Would recommend it.
Read More
6.8
Flares reduced
I am taking these as per my dermatologist's request. I've noticed that my acne isn’t flaring up like it used to, which is encouraging. While I'm not certain if it’s working fully, the price and recommendation are convincing.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
- All Researches
8
Niacinamide enhances acne treatment
Nicotinic acid/niacinamide and the skin.
Directly relevant to acne treatment
We examined how niacinamide, a form of vitamin B3, impacts acne and similar skin issues. This included looking at its potential to soothe inflammatory conditions like acne and rosacea.
Our findings suggest that niacinamide has several benefits for the skin. It helps strengthen the epidermal barrier, which means it can reduce water loss and keep the skin hydrated. Additionally, niacinamide encourages the production of proteins like keratin and supports the synthesis of important fats known as ceramides.
Not only does niacinamide contribute to healthy skin, but it also works to improve surface texture and diminish the appearance of fine lines as we age. Importantly for acne sufferers, niacinamide shows promise in providing anti-inflammatory effects, making it a potential game-changer for those battling breakouts.
By incorporating niacinamide into skincare routines, individuals may see improvements in acne and overall skin health. Given its wide-ranging benefits, it's worth considering for anyone dealing with skin that is prone to issues.
Our findings suggest that niacinamide has several benefits for the skin. It helps strengthen the epidermal barrier, which means it can reduce water loss and keep the skin hydrated. Additionally, niacinamide encourages the production of proteins like keratin and supports the synthesis of important fats known as ceramides.
Not only does niacinamide contribute to healthy skin, but it also works to improve surface texture and diminish the appearance of fine lines as we age. Importantly for acne sufferers, niacinamide shows promise in providing anti-inflammatory effects, making it a potential game-changer for those battling breakouts.
By incorporating niacinamide into skincare routines, individuals may see improvements in acne and overall skin health. Given its wide-ranging benefits, it's worth considering for anyone dealing with skin that is prone to issues.
Read More
7
Nicotinic acid may control acne
Nicotinic acid suppresses sebaceous lipogenesis of human sebocytes via activating hydroxycarboxylic acid receptor 2 (HCA ).
Relevant to acne treatment options
We investigated how nicotinic acid, also known as niacin, influences sebocytes—cells responsible for producing sebum—in the context of acne treatment. Our research focused on understanding whether niacin could effectively modulate sebaceous lipogenesis, especially in conditions where excess sebum production occurs, as seen in acne.
In our studies using immortalized human sebocyte lines, we found that when used at safe concentrations, niacin did not disrupt normal sebum production. However, it did manage to reduce excessive sebum production triggered by certain lipogenic agents, making it a potential candidate for acne management. Furthermore, we noted that niacin increased calcium signaling within the cells and showed an anti-proliferative effect, suggesting it could help regulate sebocyte activity.
Interestingly, while niacin did not inhibit inflammation caused by lipopolysaccharides, its ability to normalize excessive sebum production is noteworthy. Our findings reveal that sebocytes express hydroxycarboxylic acid receptor 2 (HCA), which seems essential for niacin's action. Silencing this receptor inhibited niacin's effects, indicating a specific pathway through which niacin could exert its influence on sebum production.
Overall, our data suggest that niacin and other HCA activators might serve as promising treatments for controlling acne by suppressing excess sebum formation, potentially offering a safer option for individuals concerned about traditional treatments that can lead to dryness.
In our studies using immortalized human sebocyte lines, we found that when used at safe concentrations, niacin did not disrupt normal sebum production. However, it did manage to reduce excessive sebum production triggered by certain lipogenic agents, making it a potential candidate for acne management. Furthermore, we noted that niacin increased calcium signaling within the cells and showed an anti-proliferative effect, suggesting it could help regulate sebocyte activity.
Interestingly, while niacin did not inhibit inflammation caused by lipopolysaccharides, its ability to normalize excessive sebum production is noteworthy. Our findings reveal that sebocytes express hydroxycarboxylic acid receptor 2 (HCA), which seems essential for niacin's action. Silencing this receptor inhibited niacin's effects, indicating a specific pathway through which niacin could exert its influence on sebum production.
Overall, our data suggest that niacin and other HCA activators might serve as promising treatments for controlling acne by suppressing excess sebum formation, potentially offering a safer option for individuals concerned about traditional treatments that can lead to dryness.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
10
Significantly clearer
I adore this niacinamide! I experience severe bacne from workouts, and after my dermatologist recommended it, my back cleared significantly in three weeks. My face is also much clearer; I previously had painful cystic acne, but none has emerged with this treatment. I subscribed after forgetting to order it once, leading to a recurrence of my acne. As someone with fair skin, I appreciate any help I can get to prevent skin cancer. Highly recommend!
Read More
9.5
Major improvement
My dermatologist suggested these to help with my acne, and I have seen a significant improvement. There are fewer red areas and less pimples on my face since starting this treatment. Would recommend it.
6.8
Flares reduced
I am taking these as per my dermatologist's request. I've noticed that my acne isn’t flaring up like it used to, which is encouraging. While I'm not certain if it’s working fully, the price and recommendation are convincing.
7.5
Effective treatment
I love this product for my acne, as my dermatologist recommended. It has been effective. However, this bottle was sent in an envelope and arrived with the top crushed, but luckily the seal was intact.
