Last update
5/4/2026
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 2 Reviews
8.3
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Niacin
500 mg
3,125%
Top Medical Research Studies
8
We evaluated the impact of niacin on anxiety and memory loss by examining its effects in male rats exposed to D-galactose, a chemical known to induce behavioral deficits. In our study, we divided the animals into six groups, with some receiving niacin at different doses (25 mg/kg and 50 mg/kg) and others being treated with D-galactose.
Over a two-week period, we observed how niacin influenced their behavior in various tests designed to measure anxiety and depression. After administering niacin, we found that it significantly reduced the anxiety and depressive symptoms that had developed due to D-galactose. This was particularly encouraging as niacin also appeared to support memory function in the rats, showing promise for addressing cognitive decline.
Biochemically, niacin treatment helped restore levels of antioxidant enzymes and neurotransmitters affected by D-galactose, demonstrating its potential to combat oxidative stress and inflammation. Our findings suggest that niacin can act as both an antioxidant and a neuromodulator, offering a valuable approach for treating anxiety and associated cognitive impairments in aging.
Over a two-week period, we observed how niacin influenced their behavior in various tests designed to measure anxiety and depression. After administering niacin, we found that it significantly reduced the anxiety and depressive symptoms that had developed due to D-galactose. This was particularly encouraging as niacin also appeared to support memory function in the rats, showing promise for addressing cognitive decline.
Biochemically, niacin treatment helped restore levels of antioxidant enzymes and neurotransmitters affected by D-galactose, demonstrating its potential to combat oxidative stress and inflammation. Our findings suggest that niacin can act as both an antioxidant and a neuromodulator, offering a valuable approach for treating anxiety and associated cognitive impairments in aging.
Read More
Most Useful Reviews
7.5
Enhances antidepressants
59 people found this helpful
Taking this alongside Zoloft significantly improves the effectiveness of my antidepressant. Over time, it has positively impacted my anxiety, mood, and skin. While I am allergic to regular niacin, this version has been amazing for me!
Read More
6
Support in recovery
25 people found this helpful
This product has been beneficial since I started using it in June 2018. I originally sought it out due to anxiety and efforts to discontinue lorazepam. While it helps, do not expect drastic changes. Other supplements like taurine, l-theanine, and magnesium are also helpful. This niacinamide is "prolonged release", avoiding strange effects on my anxiety, making it effective overall despite concerns about calcium carbonate.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
- All Researches
8
We evaluated the impact of niacin on anxiety and memory loss by examining its effects in male rats exposed to D-galactose, a chemical known to induce behavioral deficits. In our study, we divided the animals into six groups, with some receiving niacin at different doses (25 mg/kg and 50 mg/kg) and others being treated with D-galactose.
Over a two-week period, we observed how niacin influenced their behavior in various tests designed to measure anxiety and depression. After administering niacin, we found that it significantly reduced the anxiety and depressive symptoms that had developed due to D-galactose. This was particularly encouraging as niacin also appeared to support memory function in the rats, showing promise for addressing cognitive decline.
Biochemically, niacin treatment helped restore levels of antioxidant enzymes and neurotransmitters affected by D-galactose, demonstrating its potential to combat oxidative stress and inflammation. Our findings suggest that niacin can act as both an antioxidant and a neuromodulator, offering a valuable approach for treating anxiety and associated cognitive impairments in aging.
Over a two-week period, we observed how niacin influenced their behavior in various tests designed to measure anxiety and depression. After administering niacin, we found that it significantly reduced the anxiety and depressive symptoms that had developed due to D-galactose. This was particularly encouraging as niacin also appeared to support memory function in the rats, showing promise for addressing cognitive decline.
Biochemically, niacin treatment helped restore levels of antioxidant enzymes and neurotransmitters affected by D-galactose, demonstrating its potential to combat oxidative stress and inflammation. Our findings suggest that niacin can act as both an antioxidant and a neuromodulator, offering a valuable approach for treating anxiety and associated cognitive impairments in aging.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Enhances antidepressants
59 people found this helpful
Taking this alongside Zoloft significantly improves the effectiveness of my antidepressant. Over time, it has positively impacted my anxiety, mood, and skin. While I am allergic to regular niacin, this version has been amazing for me!
Read More
6
Support in recovery
25 people found this helpful
This product has been beneficial since I started using it in June 2018. I originally sought it out due to anxiety and efforts to discontinue lorazepam. While it helps, do not expect drastic changes. Other supplements like taurine, l-theanine, and magnesium are also helpful. This niacinamide is "prolonged release", avoiding strange effects on my anxiety, making it effective overall despite concerns about calcium carbonate.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Samad N, Hameed A, Manzoor N, Shoukat S, Irfan A, et al. Antioxidant and neuro-modulatory effects of niacin prevent D-galactose-induced behavioral deficits and memory impairment. Exp Gerontol. 2024;198:112624. 10.1016/j.exger.2024.112624
