Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
USERS' SCORE
Moderately Good
Based on 8 Reviews
7.9
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin C (as Ascorbic Acid)
1,000 mg
1,111%
Top Medical Research Studies
9
In our recent study, we set out to explore the effectiveness of a 5% sodium L-ascorbyl-2-phosphate lotion, a stable form of vitamin C, for treating acne. We conducted a double-blind, controlled trial with 50 participants over 12 weeks, where half used the vitamin C lotion and the other half received a placebo.
Our findings revealed significant improvements in acne symptoms for those using the vitamin C lotion compared to the placebo group. We measured outcomes through various assessments, including a global evaluation by investigators and self-reported assessments by the subjects, along with lesion counts.
The results showed that the vitamin C lotion was not only effective but also well-tolerated, with side effects similar to those seen with the placebo. This adds a promising tool to the options available for acne treatment, suggesting that vitamin C might play a valuable role in skincare regimens aimed at combating acne.
Overall, our study supports the idea that vitamin C, in the form of sodium L-ascorbyl-2-phosphate, can help reduce acne, making it a noteworthy addition to acne treatment strategies.
Our findings revealed significant improvements in acne symptoms for those using the vitamin C lotion compared to the placebo group. We measured outcomes through various assessments, including a global evaluation by investigators and self-reported assessments by the subjects, along with lesion counts.
The results showed that the vitamin C lotion was not only effective but also well-tolerated, with side effects similar to those seen with the placebo. This adds a promising tool to the options available for acne treatment, suggesting that vitamin C might play a valuable role in skincare regimens aimed at combating acne.
Overall, our study supports the idea that vitamin C, in the form of sodium L-ascorbyl-2-phosphate, can help reduce acne, making it a noteworthy addition to acne treatment strategies.
Read More
9
We explored the potential of sodium ascorbyl phosphate (SAP), a stable form of vitamin C, in preventing and treating acne vulgaris. The study included a time-kill analysis showing that a 1% SAP formulation reduced the harmful bacteria Propionibacterium acnes by a significant log reduction of 5 after 8 hours. This demonstrates the strong antimicrobial properties of SAP against acne-causing bacteria.
Additionally, we observed an in vivo study with 20 participants, where the SAP formulation effectively prevented up to 40% of UVA-induced sebum oxidation, suggesting it can help reduce inflammation associated with acne. In another open-label study involving 60 volunteers over 12 weeks, a 5% SAP lotion was rated as excellent or good in effectiveness by 76.9% of the participants, outperforming a commonly prescribed acne treatment.
Overall, our findings indicate that sodium ascorbyl phosphate could serve as an effective, non-antibiotic option for both the prevention and treatment of acne, making it an attractive addition to cosmetic products due to its lack of side effects.
Additionally, we observed an in vivo study with 20 participants, where the SAP formulation effectively prevented up to 40% of UVA-induced sebum oxidation, suggesting it can help reduce inflammation associated with acne. In another open-label study involving 60 volunteers over 12 weeks, a 5% SAP lotion was rated as excellent or good in effectiveness by 76.9% of the participants, outperforming a commonly prescribed acne treatment.
Overall, our findings indicate that sodium ascorbyl phosphate could serve as an effective, non-antibiotic option for both the prevention and treatment of acne, making it an attractive addition to cosmetic products due to its lack of side effects.
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8
We aimed to explore how magnesium ascorbyl phosphate (MAP), a stable form of vitamin C, influences acne by evaluating its impact on inflammatory responses in skin cells known as sebocytes. The study employed a robust methodology, where we treated cultured sebocytes with different solutions: MAP, lipopolysaccharide (LPS), and a combination of both.
Following treatment, we measured the expression of inflammatory markers, cytokines, and proteins involved in skin inflammation and the healing process. Our findings revealed that MAP effectively reduced the heightened inflammatory responses caused by LPS, suggesting it has a calming effect on acne-related inflammation.
Additionally, we observed a notable decrease in lipid peroxidation, a contributor to skin damage, after treatment with MAP. This means that vitamin C may not only help reduce inflammation but could also protect skin cells from oxidative stress, promoting healthier skin overall.
In summary, our study strengthens the idea that using MAP can be a beneficial addition to acne treatments, potentially leading to improved skin conditions.
Following treatment, we measured the expression of inflammatory markers, cytokines, and proteins involved in skin inflammation and the healing process. Our findings revealed that MAP effectively reduced the heightened inflammatory responses caused by LPS, suggesting it has a calming effect on acne-related inflammation.
Additionally, we observed a notable decrease in lipid peroxidation, a contributor to skin damage, after treatment with MAP. This means that vitamin C may not only help reduce inflammation but could also protect skin cells from oxidative stress, promoting healthier skin overall.
In summary, our study strengthens the idea that using MAP can be a beneficial addition to acne treatments, potentially leading to improved skin conditions.
Read More
Most Useful Reviews
9.5
Acne improved significantly
At first, I took one tablet daily but felt no effect. Since it's water-soluble vitamin C, I tried taking three times a day, and my acne vanished, leaving my skin beautiful. Given the current hype around high vitamin C intake, I think it's worth trying again at this price.
Read More
9.5
Significant acne improvement
Effective for adolescent acne. My junior high school daughter’s red acne improved significantly overnight. The taste is sour, but the skin-beautifying effects of vitamin C are genuinely felt.
Read More
7.5
Calming acne sensation
It's okay. The taste didn't match in the end. I've been taking this with silica and MSM. With numerous acne, I feel like it's starting to calm down.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
- All Researches
9
Vitamin C shows moderate efficacy
We explored the effectiveness of using vitamin C in treating persistent post-acne erythema, which often leaves visible redness after acne has cleared. In this study, participants received microneedling combined with either a 10% vitamin C solution or a tranexamic acid solution. The goal was to see which treatment worked better for reducing redness and improving overall skin appearance.
Four treatment sessions were spaced two weeks apart, followed by assessments two weeks after the final session. We measured improvements using clinical evaluations, 3D imaging technology to analyze blood flow in the skin, and patient feedback.
Our findings indicated that both treatments led to significant improvements in reducing skin redness. However, the tranexamic acid solution yielded even better results compared to vitamin C. Patients reported satisfaction on both sides, but they favored the effects of tranexamic acid more. Notably, any side effects were minimal and temporary.
This study suggests that while vitamin C can be helpful, using microneedling with tranexamic acid may deliver superior results for those struggling with post-acne redness.
Four treatment sessions were spaced two weeks apart, followed by assessments two weeks after the final session. We measured improvements using clinical evaluations, 3D imaging technology to analyze blood flow in the skin, and patient feedback.
Our findings indicated that both treatments led to significant improvements in reducing skin redness. However, the tranexamic acid solution yielded even better results compared to vitamin C. Patients reported satisfaction on both sides, but they favored the effects of tranexamic acid more. Notably, any side effects were minimal and temporary.
This study suggests that while vitamin C can be helpful, using microneedling with tranexamic acid may deliver superior results for those struggling with post-acne redness.
Read More
9
We aimed to understand how a novel formulation combining vitamin C and quercetin can help treat acne. Our study focused on creating small liposomal structures called aspasomes that enhance the delivery of quercetin, a potent antioxidant, onto the skin.
Throughout our research, we thoroughly characterized these aspasomes for their size, stability, and how well they could penetrate the skin. One exciting finding was that these specialized nanovesicles not only preserved the antioxidant benefits of quercetin, but also demonstrated a stronger antibacterial effect against acne-causing bacteria compared to quercetin alone.
In an exploratory clinical trial involving 20 participants with acne, we observed considerable improvements. The results revealed a 77.9% reduction in inflammatory lesions and significant decreases in both non-inflammatory lesions and total acne lesions. These findings suggest that our vitamin C-based formula holds promise in managing acne and could potentially be used for other skin conditions in the future.
Throughout our research, we thoroughly characterized these aspasomes for their size, stability, and how well they could penetrate the skin. One exciting finding was that these specialized nanovesicles not only preserved the antioxidant benefits of quercetin, but also demonstrated a stronger antibacterial effect against acne-causing bacteria compared to quercetin alone.
In an exploratory clinical trial involving 20 participants with acne, we observed considerable improvements. The results revealed a 77.9% reduction in inflammatory lesions and significant decreases in both non-inflammatory lesions and total acne lesions. These findings suggest that our vitamin C-based formula holds promise in managing acne and could potentially be used for other skin conditions in the future.
Read More
9
We conducted a study to explore the effectiveness of two forms of vitamin C—ascorbyl palmitate (AP) and sodium ascorbyl phosphate (SAP)—in managing sebum production on the skin. Through a single-blinded, placebo-controlled trial involving 11 healthy female volunteers, we compared the effects of a multiple emulsion containing these compounds with a control that lacked them.
Over 90 days, participants applied the vitamin C formulation to one cheek and the control to the other. We measured sebum levels using a non-invasive device called a Sebumeter at different time intervals. Our results demonstrated that the combination of AP and SAP achieved notable antioxidant activity and effectively reduced facial oiliness compared to the control.
Ultimately, we found that incorporating vitamin C into skincare routines can be a promising solution for controlling excess facial sebum, which is often linked to oily skin and acne. However, while the study highlights the role of these antioxidants in sebum regulation, it does not provide a definitive conclusion on their isolated effects solely for acne treatment.
Over 90 days, participants applied the vitamin C formulation to one cheek and the control to the other. We measured sebum levels using a non-invasive device called a Sebumeter at different time intervals. Our results demonstrated that the combination of AP and SAP achieved notable antioxidant activity and effectively reduced facial oiliness compared to the control.
Ultimately, we found that incorporating vitamin C into skincare routines can be a promising solution for controlling excess facial sebum, which is often linked to oily skin and acne. However, while the study highlights the role of these antioxidants in sebum regulation, it does not provide a definitive conclusion on their isolated effects solely for acne treatment.
Read More
9
We explored the effectiveness of a vitamin C derivative, zinc ascorbate, for treating acne. This study focused on its in vitro antimicrobial activity against Propionibacterium acnes, the bacteria often responsible for acne breakouts.
The researchers tested zinc ascorbate alone and in combination with popular antibiotics like clindamycin, widely used in Japan for acne treatment. They examined how these combinations worked against various strains of P. acnes, including those resistant to clindamycin.
Findings indicated that zinc ascorbate can effectively inhibit the growth of P. acnes, even in clindamycin-resistant strains. Notably, when combined with clindamycin, zinc ascorbate demonstrated an additive effect, enhancing its overall antimicrobial effectiveness.
Overall, this research suggests that incorporating zinc ascorbate could be a promising strategy for acne treatment, especially in conjunction with traditional antibiotics.
The researchers tested zinc ascorbate alone and in combination with popular antibiotics like clindamycin, widely used in Japan for acne treatment. They examined how these combinations worked against various strains of P. acnes, including those resistant to clindamycin.
Findings indicated that zinc ascorbate can effectively inhibit the growth of P. acnes, even in clindamycin-resistant strains. Notably, when combined with clindamycin, zinc ascorbate demonstrated an additive effect, enhancing its overall antimicrobial effectiveness.
Overall, this research suggests that incorporating zinc ascorbate could be a promising strategy for acne treatment, especially in conjunction with traditional antibiotics.
Read More
9
In our recent study, we set out to explore the effectiveness of a 5% sodium L-ascorbyl-2-phosphate lotion, a stable form of vitamin C, for treating acne. We conducted a double-blind, controlled trial with 50 participants over 12 weeks, where half used the vitamin C lotion and the other half received a placebo.
Our findings revealed significant improvements in acne symptoms for those using the vitamin C lotion compared to the placebo group. We measured outcomes through various assessments, including a global evaluation by investigators and self-reported assessments by the subjects, along with lesion counts.
The results showed that the vitamin C lotion was not only effective but also well-tolerated, with side effects similar to those seen with the placebo. This adds a promising tool to the options available for acne treatment, suggesting that vitamin C might play a valuable role in skincare regimens aimed at combating acne.
Overall, our study supports the idea that vitamin C, in the form of sodium L-ascorbyl-2-phosphate, can help reduce acne, making it a noteworthy addition to acne treatment strategies.
Our findings revealed significant improvements in acne symptoms for those using the vitamin C lotion compared to the placebo group. We measured outcomes through various assessments, including a global evaluation by investigators and self-reported assessments by the subjects, along with lesion counts.
The results showed that the vitamin C lotion was not only effective but also well-tolerated, with side effects similar to those seen with the placebo. This adds a promising tool to the options available for acne treatment, suggesting that vitamin C might play a valuable role in skincare regimens aimed at combating acne.
Overall, our study supports the idea that vitamin C, in the form of sodium L-ascorbyl-2-phosphate, can help reduce acne, making it a noteworthy addition to acne treatment strategies.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 8 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Acne improved significantly
At first, I took one tablet daily but felt no effect. Since it's water-soluble vitamin C, I tried taking three times a day, and my acne vanished, leaving my skin beautiful. Given the current hype around high vitamin C intake, I think it's worth trying again at this price.
Read More
9.5
Significant acne improvement
Effective for adolescent acne. My junior high school daughter’s red acne improved significantly overnight. The taste is sour, but the skin-beautifying effects of vitamin C are genuinely felt.
Read More
7.5
Calming acne sensation
It's okay. The taste didn't match in the end. I've been taking this with silica and MSM. With numerous acne, I feel like it's starting to calm down.
Read More
9.5
Skin improved noticeably
I will continue taking this! I take one pill daily; it’s easy to swallow and doesn’t get stuck. It’s my first sustained release experience, but I love how my skin feels and looks smooth by morning. My acne scars have started to fade, and I’m hopeful they will disappear with a few more months' use!
Read More
7.5
More stable skin condition
After taking it, I feel my skin condition is more stable and less prone to acne.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Sharara MA, Fawaz GA, El Samahy MH. Efficacy of tranexamic acid solution versus vitamin C solution after micro-needling in treatment of persistent post acne erythema: a split face clinical and 3DAntera camera comparative study. Arch Dermatol Res. 2024;317:150. doi:10.1007/s00403-024-03582-0
- Golonka I, Łukasiewicz IW, Sebastiańczyk A, Greber KE, Sawicki W, et al. The Influence of the Amphiphilic Properties of Peptides on the Phosphatidylinositol Monolayer in the Presence of Ascorbic Acid. Int J Mol Sci. 2024;25. doi:10.3390/ijms252312484
- Hu JK, Quinonez RL, Antasiuk V, Waibel J. Treatment of Acne Vulgaris-Associated Post-Inflammatory Dyschromia With Combination of Non-Ablative Laser Therapy and Topical Antioxidants. J Drugs Dermatol. 2024;23:769. doi:10.36849/JDD.8309
- Abbas MAM, Elgamal EEAE, Zaky MS, Elsaie ML. Microneedling with topical vitamin C versus microneedling with topical insulin in the treatment of atrophic post-acne scars: A split-face study. Dermatol Ther. 2022;35:e15376. doi:10.1111/dth.15376
- Sawutdeechaikul P, Kanokrungsee S, Sahaspot T, Thadvibun K, Banlunara W, et al. Detachable dissolvable microneedles: intra-epidermal and intradermal diffusion, effect on skin surface, and application in hyperpigmentation treatment. Sci Rep. 2021;11:24114. doi:10.1038/s41598-021-03503-5
- Amer SS, Nasr M, Abdel-Aziz RTA, Moftah NH, El Shaer A, et al. Cosm-nutraceutical nanovesicles for acne treatment: Physicochemical characterization and exploratory clinical experimentation. Int J Pharm. 2020;577:119092. doi:10.1016/j.ijpharm.2020.119092
- Vasanth S, Dubey A, G S R, Lewis SA, Ghate VM, et al. Development and Investigation of Vitamin C-Enriched Adapalene-Loaded Transfersome Gel: a Collegial Approach for the Treatment of Acne Vulgaris. AAPS PharmSciTech. 2020;21:61. doi:10.1208/s12249-019-1518-5
- Khan H, Akhtar N, Ali A. Assessment of Combined Ascorbyl Palmitate (AP) and Sodium Ascorbyl Phosphate (SAP) on Facial Skin Sebum Control in Female Healthy Volunteers. Drug Res (Stuttg). 2017;67:52. doi:10.1055/s-0042-118171
- Jain A, Garg NK, Jain A, Kesharwani P, Jain AK, et al. A synergistic approach of adapalene-loaded nanostructured lipid carriers, and vitamin C co-administration for treating acne. Drug Dev Ind Pharm. 2016;42:897. doi:10.3109/03639045.2015.1104343
- Lee WJ, Kim SL, Choe YS, Jang YH, Lee SJ, et al. Magnesium Ascorbyl Phosphate Regulates the Expression of Inflammatory Biomarkers in Cultured Sebocytes. Ann Dermatol. 2015;27:376. doi:10.5021/ad.2015.27.4.376
- Ikeno H, Apel M, Zouboulis C, Luger TA, Böhm M. L-Ascorbyl-2-phosphate attenuates NF-κB signaling in SZ95 sebocytes without affecting IL-6 and IL-8 secretion. Arch Dermatol Res. 2015;307:595. doi:10.1007/s00403-015-1565-z
- Chawla S. Split Face Comparative Study of Microneedling with PRP Versus Microneedling with Vitamin C in Treating Atrophic Post Acne Scars. J Cutan Aesthet Surg. 2014;7:209. doi:10.4103/0974-2077.150742
- Iinuma K, Noguchi N, Nakaminami H, Sasatsu M, Nishijima S, et al. Susceptibility of Propionibacterium acnes isolated from patients with acne vulgaris to zinc ascorbate and antibiotics. Clin Cosmet Investig Dermatol. 2011;4:161. doi:10.2147/CCID.S23840
- Woolery-Lloyd H, Baumann L, Ikeno H. Sodium L-ascorbyl-2-phosphate 5% lotion for the treatment of acne vulgaris: a randomized, double-blind, controlled trial. J Cosmet Dermatol. 2010;9:22. doi:10.1111/j.1473-2165.2010.00480.x
- Burgess C. Topical vitamins. J Drugs Dermatol. 2008;7:s2.
- Klock J, Ikeno H, Ohmori K, Nishikawa T, Vollhardt J, et al. Sodium ascorbyl phosphate shows in vitro and in vivo efficacy in the prevention and treatment of acne vulgaris. Int J Cosmet Sci. 2005;27:171. doi:10.1111/j.1467-2494.2005.00263.x
