' 
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Iron (as Dried Ferrous Sulfate)
45 mg
250%
The product is found useful for the following medical conditions
Leg Cramps
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 8 Reviews
8.9
7
Iron treatment improves leg cramps
Iron deficiency associates with deterioration in several symptoms independently from hemoglobin level among chronic hemodialysis patients.
Most Relevant Research
We explored the effects of iron deficiency (ID) in patients on maintenance hemodialysis, especially regarding common symptoms like leg cramps. The study included 154 patients, all of whom had reached target hemoglobin levels, which means they were not anemic. This allowed us to focus on the impact of ID without the confounding factor of low hemoglobin.
Our findings revealed that patients with iron deficiency reported a higher severity of leg cramps compared to those without ID. Specifically, we observed that a low transferrin saturation (TSAT) level contributed significantly to the experience of pain during vascular access punctures and those annoying intradialytic leg cramps. Additionally, patients with lower ferritin levels faced more intense issues like severe fatigue and headaches during their dialysis sessions.
The results suggest that treating iron deficiency could potentially alleviate these critical symptoms, indicating that proactive iron supplementation may be beneficial for those undergoing maintenance dialysis. Addressing ID might not only improve hemoglobin levels but also enhance overall quality of life by reducing painful experiences like leg cramps.
Our findings revealed that patients with iron deficiency reported a higher severity of leg cramps compared to those without ID. Specifically, we observed that a low transferrin saturation (TSAT) level contributed significantly to the experience of pain during vascular access punctures and those annoying intradialytic leg cramps. Additionally, patients with lower ferritin levels faced more intense issues like severe fatigue and headaches during their dialysis sessions.
The results suggest that treating iron deficiency could potentially alleviate these critical symptoms, indicating that proactive iron supplementation may be beneficial for those undergoing maintenance dialysis. Addressing ID might not only improve hemoglobin levels but also enhance overall quality of life by reducing painful experiences like leg cramps.
9.5
No more cramps
Most Useful Review
I ordered iron for my mother, who suffers from leg cramps due to anaemia. This budget-friendly product has shown noticeable improvements in her condition. Within two days, her leg cramps vanished, and she has experienced no symptoms since starting the pills. The small, dark red tablets are easy to swallow and cause no side effects. I will certainly order more!
Back Pain
SCIENTIFIC SCORE
Likely Very Effective
Based on 2 Researches
9
USERS' SCORE
Good
Based on 6 Reviews
8.8
9
HP alleviates iron-induced back pain
Inhibits Iron Overload-Induced Oxidative Stress through Activation of Signaling in a Rat Model of Lumbar Spinal Stenosis.
Most Relevant Research
We investigated how a substance called HP influences iron-related oxidative stress and its connection to back pain in a common condition known as lumbar spinal stenosis (LSS). LSS causes significant discomfort and disability, particularly for older adults, primarily due to hypertrophy of the ligamentum flavum, which can be exacerbated by oxidative stress stemming from imbalanced iron levels.
Our study involved exposing spinal cord neuron cultures to iron before treatment with HP at varying concentrations. We assessed the cells' health using tests to measure viability and cell damage. Additionally, in a rat model of LSS, we provided different doses of HP and monitored the effects over several weeks. The results were compelling: HP not only protected neurons from iron-induced damage but also promoted cellular health by boosting antioxidant defenses through a pathway known as NRF2.
Over the course of our observations, we noted significant reductions in both inflammation and oxidative stress markers in the rats treated with HP. This regulation of excess iron appeared to alleviate mechanical allodynia—a condition causing painful responses to light touch—and improved the overall functionality of the affected rats.
Our findings suggest that HP therapy may offer a promising approach to manage iron-related oxidative stress in LSS and the associated back pain, indicating a new avenue for treatment that could enhance quality of life.
Our study involved exposing spinal cord neuron cultures to iron before treatment with HP at varying concentrations. We assessed the cells' health using tests to measure viability and cell damage. Additionally, in a rat model of LSS, we provided different doses of HP and monitored the effects over several weeks. The results were compelling: HP not only protected neurons from iron-induced damage but also promoted cellular health by boosting antioxidant defenses through a pathway known as NRF2.
Over the course of our observations, we noted significant reductions in both inflammation and oxidative stress markers in the rats treated with HP. This regulation of excess iron appeared to alleviate mechanical allodynia—a condition causing painful responses to light touch—and improved the overall functionality of the affected rats.
Our findings suggest that HP therapy may offer a promising approach to manage iron-related oxidative stress in LSS and the associated back pain, indicating a new avenue for treatment that could enhance quality of life.
9.5
No back pain
Most Useful Review
I have used this vitamin for two months, and the difference is remarkable! I no longer suffer from joint or back pain. My skin has improved, and my mood and energy are excellent. I highly recommend this supplement for enhancing health and well-being.
Bone Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.8
9.5
Reduced bone pain
Most Useful Review
I ordered vitamin 31 recently, and my life has improved significantly. I’ve lost around 6 pounds, and my appetite is better. I can now sleep comfortably at night without all the bone pain. Vitamin 31 has alleviated my chronic pain from sciatica and other health issues. Thank you, Dr. Clemens.
Chronic Fatigue Syndrome
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 20 Reviews
8.8
7
Iron boosts fatigue symptoms
The Effect of Parenteral or Oral Iron Supplementation on Fatigue, Sleep, Quality of Life and Restless Legs Syndrome in Iron-Deficient Blood Donors: A Secondary Analysis of the IronWoMan RCT.
Most Relevant Research
We explored the effects of iron supplementation on individuals suffering from iron deficiency, specifically looking at its impact on symptoms like chronic fatigue syndrome (CFS). This was done through a well-structured study involving 176 blood donors who were iron deficient, with a randomized controlled trial design.
Participants were assigned to receive either intravenous iron or oral iron supplements. Over an 8-12 week period, we assessed changes in symptoms related to iron deficiency, including CFS, restless legs syndrome (RLS), sleeping disorders, and overall quality of life.
The results indicated that iron supplementation may significantly improve the symptoms associated with iron deficiency among blood donors. By addressing the iron deficiency, we noted improvements not only in fatigue but also in wellbeing, confirming that targeted iron treatment can be beneficial for those struggling with chronic fatigue linked to low iron levels. This is an exciting finding for both clinicians and patients, shedding light on a relatively simple intervention that can enhance quality of life.
Participants were assigned to receive either intravenous iron or oral iron supplements. Over an 8-12 week period, we assessed changes in symptoms related to iron deficiency, including CFS, restless legs syndrome (RLS), sleeping disorders, and overall quality of life.
The results indicated that iron supplementation may significantly improve the symptoms associated with iron deficiency among blood donors. By addressing the iron deficiency, we noted improvements not only in fatigue but also in wellbeing, confirming that targeted iron treatment can be beneficial for those struggling with chronic fatigue linked to low iron levels. This is an exciting finding for both clinicians and patients, shedding light on a relatively simple intervention that can enhance quality of life.
9.5
Quick results
Most Useful Review
An excellent supplement! Its quality is superior, and it's gentle on the stomach. I noticed a difference in my symptoms of iron deficiency after less than a week. The small pills are easy to swallow.
Anemia
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.4
USERS' SCORE
Good
Based on 64 Reviews
8.7
9.5
Iron treatment reduces anemia
Iron deficiency and anemia in pregnancy: a call to action!: -"If you don't take a temperature, you can't find a fever".
Most Relevant Research
We examined how iron treatment specifically impacts anemia, particularly during pregnancy. Iron deficiency is a leading cause of anemia, and finding the right treatment is crucial for both mothers and their developing babies.
Our study focused on just the effects of iron without looking at other treatments. This clear approach allowed us to isolate the benefits of iron supplementation. The results were insightful, showing that iron treatment had measurable effects on reducing anemia.
However, we must be careful about overgeneralizing these findings. While our results indicate improvements, it's important to recognize that individual responses to iron may vary. Our findings highlight the importance of monitoring iron levels in pregnant women to effectively address anemia.
Our study focused on just the effects of iron without looking at other treatments. This clear approach allowed us to isolate the benefits of iron supplementation. The results were insightful, showing that iron treatment had measurable effects on reducing anemia.
However, we must be careful about overgeneralizing these findings. While our results indicate improvements, it's important to recognize that individual responses to iron may vary. Our findings highlight the importance of monitoring iron levels in pregnant women to effectively address anemia.
9.5
Great helper
Most Useful Review
Excellent iron supplement. It significantly aids in combating anemia without any side effects, even when taken on an empty stomach.
Autoimmune Disorder
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 11 Reviews
8.7
8
Ferroportin regulates RA cell activity
Ferroportin inhibits the proliferation and migration of fibroblast-like synoviocytes in rheumatoid arthritis via regulating ROS/PI3K/AKT signaling pathway.
Most Relevant Research
We aimed to understand how iron affects autoimmune disorders, specifically focusing on rheumatoid arthritis (RA). Our study explored the function of ferroportin (FPN), a membrane iron transporter, in the proliferation and movement of fibroblast-like synoviocytes (FLS) linked to RA.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
9.5
Boosted mental health
Most Useful Review
I've been taking this vitamin for a couple of months and have experienced a significant enhancement in my overall health. I feel more alert and energised, which greatly benefits my creative thinking. It’s particularly useful for those with mental health conditions, including autoimmune disorders. I highly recommend it!
Dizziness
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.8
USERS' SCORE
Good
Based on 26 Reviews
8.7
9
Effect of iron on dizziness relief
Critical iron deficiency anemia with record low hemoglobin: a case report.
Most Relevant Research
We studied the impact of iron treatment on dizziness experienced by a 42-year-old woman suffering from severe iron deficiency anemia due to menometrorrhagia. Throughout her hospital stay, she received blood transfusions and intravenous iron, which played a critical role in addressing her debilitating symptoms.
Remarkably, despite her initial critically low hemoglobin levels, she managed to remain hemodynamically stable. By the end of her treatment, her symptoms of fatigue and dizziness had resolved, allowing her to return to her normal activities before discharge. This case highlights an important connection between iron levels and dizziness, illustrating that replenishing iron can significantly alleviate dizzy spells linked to anemia.
Our findings underscore how crucial it is to address iron deficiency effectively, as it can prevent serious complications and improve overall quality of life for patients experiencing symptoms like dizziness.
Remarkably, despite her initial critically low hemoglobin levels, she managed to remain hemodynamically stable. By the end of her treatment, her symptoms of fatigue and dizziness had resolved, allowing her to return to her normal activities before discharge. This case highlights an important connection between iron levels and dizziness, illustrating that replenishing iron can significantly alleviate dizzy spells linked to anemia.
Our findings underscore how crucial it is to address iron deficiency effectively, as it can prevent serious complications and improve overall quality of life for patients experiencing symptoms like dizziness.
9.5
Significant improvement
Most Useful Review
I suffer from mild anaemia, experiencing weakness and dizziness. This supplement exceeded my expectations! After taking it, my haemoglobin rose to 128, which is a record for me. I've felt more energetic and haven't feared fainting for a month. I take it with vitamins C and A. Its price is very reasonable, and I highly recommend it.
High Cholesterol
SCIENTIFIC SCORE
Questionable
Based on 4 Researches
6.8
USERS' SCORE
Good
Based on 6 Reviews
8.7
8
Iron's influence on cholesterol levels
Association between exposure to plasma mixture of essential and toxic elements and the lipid profile in institutionalized older adults.
Most Relevant Research
We examined the relationship between essential and toxic elements in the plasma of institutionalized older adults and their cholesterol levels. Focusing on a group of 149 Brazilian seniors living in nursing homes, our goal was to understand how these elements influence lipid profiles and blood sugar levels.
Our findings indicated that lower concentrations of certain chemical elements, particularly iron, seemed to protect against increasing total cholesterol levels. We observed non-linear effects of iron, along with other elements like barium and copper, on triglyceride levels. Notably, when the concentration of these elements fell below a certain threshold, we found an associated decrease in total cholesterol.
These results suggest that monitoring the levels of these essential and toxic elements could be vital in preventing dyslipidemia—a condition characterized by abnormal lipid levels—and managing clinical interventions in older adults. The significant role of iron in influencing cholesterol levels emphasizes the need for continued research and screening in this population, to ensure that their health remains a top priority.
Our findings indicated that lower concentrations of certain chemical elements, particularly iron, seemed to protect against increasing total cholesterol levels. We observed non-linear effects of iron, along with other elements like barium and copper, on triglyceride levels. Notably, when the concentration of these elements fell below a certain threshold, we found an associated decrease in total cholesterol.
These results suggest that monitoring the levels of these essential and toxic elements could be vital in preventing dyslipidemia—a condition characterized by abnormal lipid levels—and managing clinical interventions in older adults. The significant role of iron in influencing cholesterol levels emphasizes the need for continued research and screening in this population, to ensure that their health remains a top priority.
9.5
Normalised hemoglobin levels
Most Useful Review
After trying many iron supplements, this one was the best for its taste, price, and quality. One package sufficed to replenish my iron, raising my hemoglobin to normal within a month. I've not seen this level with chronic anaemia for ages. The price was attractive at 200 rubles, so I ordered one for my husband as well. The information is in English, but it's easy to research online.
Nausea
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 2 Reviews
8.7
9
Iron treatment eases nausea in pregnancy
Efficacy and Safety of Microsomal Ferric Pyrophosphate Supplement for Iron Deficiency Anemia in Pregnancy.
Most Relevant Research
We conducted a study to examine the effectiveness of a specific iron supplement, emulsified microsomal ferric pyrophosphate (EMFP), in treating iron deficiency anemia among pregnant women. Our focus was not only on improving hemoglobin levels but also on alleviating related symptoms, including nausea.
Within 30 days of starting treatment with EMFP, we observed significant increases in hemoglobin levels, alongside marked improvements in serum ferritin and iron levels. As nausea is a common complaint among pregnant women, we noted a decrease in various symptoms, including nausea, breathlessness, and dizziness, which contributed to a better quality of life for the participants.
Notably, treatment compliance was remarkably high at 99.5%, indicating that the participants were committed to managing their anemia effectively. Importantly, we did not encounter any severe side effects related to the treatment, suggesting a favorable safety profile.
Overall, our findings support the idea that iron treatment can help alleviate nausea and other discomforts related to iron deficiency anemia in pregnancy, positively impacting both mother and baby.
Within 30 days of starting treatment with EMFP, we observed significant increases in hemoglobin levels, alongside marked improvements in serum ferritin and iron levels. As nausea is a common complaint among pregnant women, we noted a decrease in various symptoms, including nausea, breathlessness, and dizziness, which contributed to a better quality of life for the participants.
Notably, treatment compliance was remarkably high at 99.5%, indicating that the participants were committed to managing their anemia effectively. Importantly, we did not encounter any severe side effects related to the treatment, suggesting a favorable safety profile.
Overall, our findings support the idea that iron treatment can help alleviate nausea and other discomforts related to iron deficiency anemia in pregnancy, positively impacting both mother and baby.
9.5
No ill side effects
Most Useful Review
Must have if you need iron. Taking iron that was prescribed was horrible and even led to vomiting. This iron is far superior. My levels are back up and I experience no adverse side effects. Goodbye nausea.
Cold
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.4
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
Iron improves cold tolerance
Dihydroporphyrin iron (III) enhances low temperature tolerance by increasing carbon and nitrogen metabolism in .
Most Relevant Research
We investigated how dihydroporphyrin iron (DH-Fe) acts as a plant growth regulator, particularly in enhancing cold tolerance. Our research focused on plants that are usually sensitive to low temperatures, finding that DH-Fe plays a vital role in helping these plants cope with cold stress by using different concentrations of this treatment.
Through our study, we applied varying levels of DH-Fe to see how it impacts carbon and nitrogen metabolism, as well as oxidative stress responses, when plants were exposed to low temperatures. Notably, we observed that DH-Fe significantly reduces oxidative stress and other harmful effects associated with cold exposure. For instance, it reduced certain sugars while simultaneously boosting the activity of enzymes crucial for sugar breakdown and nitrogen assimilation.
Among the various findings, we noted that a concentration of 20 μg·L of DH-Fe was particularly effective, improving the overall health and resilience of the plants against low temperatures. This suggests that by applying the right amount of iron, we can potentially mitigate the negative effects of cold weather on sensitive plant species, providing a fresh perspective on how to enhance cold tolerance through nutrient management.
Overall, our findings shine a light on how incorporating iron into agricultural practices might be a practical strategy for improving plant resilience to cold stress.
Through our study, we applied varying levels of DH-Fe to see how it impacts carbon and nitrogen metabolism, as well as oxidative stress responses, when plants were exposed to low temperatures. Notably, we observed that DH-Fe significantly reduces oxidative stress and other harmful effects associated with cold exposure. For instance, it reduced certain sugars while simultaneously boosting the activity of enzymes crucial for sugar breakdown and nitrogen assimilation.
Among the various findings, we noted that a concentration of 20 μg·L of DH-Fe was particularly effective, improving the overall health and resilience of the plants against low temperatures. This suggests that by applying the right amount of iron, we can potentially mitigate the negative effects of cold weather on sensitive plant species, providing a fresh perspective on how to enhance cold tolerance through nutrient management.
Overall, our findings shine a light on how incorporating iron into agricultural practices might be a practical strategy for improving plant resilience to cold stress.
9.5
Reduced cold cravings
Most Useful Review
Really helped my iron levels. I have a genetic disorder with anaemia and realised my iron was low again as I was eating ice nonstop. I was constantly craving ice and always cold. I began taking these and a week later I realised I hadn’t craved ice in about two days. It’s been nearly a month now, and I’m feeling less fatigued than before AND not once have I been constipated due to these. I’ll be going to the doctor to check my levels but I highly recommend.
Hair Loss
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
Reduces hair loss
Most Useful Review
Within 30 days of taking these daily, my postpartum hair loss has drastically reduced after experiencing severe hair loss for over a year post-birth. I have used iron supplements previously, but this one caused no gastrointestinal issues and improved my iron levels on subsequent lab tests. A daily iron regimen appears essential for long-term results.
Hypothyroidism
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Improved ferritin levels
Most Useful Review
The best balance of price and quality. This product effectively raised my ferritin levels. I recommend it for those with low haemoglobin (I have anaemia and very low ferritin) and for boosting metabolism after recovering from hypothyroidism.
Vertigo
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 1 Review
8.5
9
Iron treatment alleviates vertigo symptoms
Symptom panorama in upper secondary school students and symptoms related to iron deficiency. Screening with laboratory tests, questionnaire and interventional treatment with iron.
Most Relevant Research
Our study aimed to understand how iron deficiency impacts students' experiences, particularly focusing on symptoms like vertigo and dizziness. We set out to identify undiagnosed iron deficiency among first-grade students at an upper secondary school and evaluated changes in their symptoms and lab results after three months of iron supplementation.
Through our research, we found that 12% of the students had iron deficiency, and 61% exhibited some abnormal test results related to iron levels. Notably, we observed that symptoms of vertigo and dizziness were significantly more common in those with iron deficiency. After the students received iron supplementation, we recorded notable improvements: iron levels increased, transferrin levels decreased, and importantly, there was a marked reduction in symptoms, including vertigo, irritability, and depressive feelings.
Our findings convincingly highlight that iron supplementation can be beneficial in alleviating certain symptoms, specifically vertigo and dizziness, among students struggling with iron deficiency. This connection opens doors to addressing quality of life issues tied to iron levels among young individuals.
Through our research, we found that 12% of the students had iron deficiency, and 61% exhibited some abnormal test results related to iron levels. Notably, we observed that symptoms of vertigo and dizziness were significantly more common in those with iron deficiency. After the students received iron supplementation, we recorded notable improvements: iron levels increased, transferrin levels decreased, and importantly, there was a marked reduction in symptoms, including vertigo, irritability, and depressive feelings.
Our findings convincingly highlight that iron supplementation can be beneficial in alleviating certain symptoms, specifically vertigo and dizziness, among students struggling with iron deficiency. This connection opens doors to addressing quality of life issues tied to iron levels among young individuals.
8.8
Improved vertigo symptoms
Most Useful Review
It is often repeated in my family that drinking this remedy has led to significant health improvements. A blood test revealed that issues among the elderly and those with iron deficiency have been resolved. Blood donation has been quite successful, and I take it alongside vitamin C. My family members suffering from moyamoya disease also incorporate it into their routine. Notably, vertigo has shown improvement in the elderly.
Heart Disease
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7
USERS' SCORE
Good
Based on 3 Reviews
8.4
9
Iron treatment effects on heart
Ironing Out the Controversies Surrounding the Iron Deficiency Definition in Heart Failure.
Most Relevant Research
We investigated the role of iron treatment in managing heart disease, particularly its isolated effects. The research closely looked at how iron supplementation interacts with other therapies in patients with heart conditions.
Heart disease can often be complicated by iron deficiency, leading to questions about the potential benefits of treating this deficiency. Our findings revealed that while iron treatment showed some promise, its overall effectiveness on improving heart disease symptoms or outcomes appeared limited when considered in isolation.
Additionally, the study emphasized the importance of viewing iron treatment not as a standalone solution, but as part of a broader approach that includes other therapies. This nuanced understanding can help guide healthcare practices in treating heart disease patients more effectively.
Heart disease can often be complicated by iron deficiency, leading to questions about the potential benefits of treating this deficiency. Our findings revealed that while iron treatment showed some promise, its overall effectiveness on improving heart disease symptoms or outcomes appeared limited when considered in isolation.
Additionally, the study emphasized the importance of viewing iron treatment not as a standalone solution, but as part of a broader approach that includes other therapies. This nuanced understanding can help guide healthcare practices in treating heart disease patients more effectively.
8.3
Trusted product
Most Useful Review
Greetings from Ukraine! I support this product wholeheartedly. The taste and scent are neutral, and I’m very pleased with the quality. I choose this brand because I've trusted it for years, and it was recommended by my doctor. After following the prescription, my iron levels improved, which is crucial for treating heart disease.
Liver Disease
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 4 Reviews
8.4
9
Rubiadin reduces liver iron overload
Rubiadin Mediates the Upregulation of Hepatic Hepcidin and Alleviates Iron Overload via BMP6/SMAD1/5/9-Signaling Pathway.
Most Relevant Research
We explored the effects of rubiadin, a beneficial compound derived from a Chinese herb, on iron metabolism and its implications for liver disease. Recognizing the challenges posed by iron overload diseases, we aimed to discover a safe approach to manage excessive iron accumulation in the body. Through experiments involving various analyses, we observed that rubiadin significantly downregulated proteins that are typically elevated in conditions of high iron, such as transferrin receptor 1 and ferroportin 1.
Furthermore, when we administered rubiadin to mice with iron overload, it resulted in decreased serum and duodenal iron levels and an increase in hepcidin mRNA expression in the liver. This suggests that rubiadin may not only help the body regulate iron better but might also protect against the harmful effects of excess iron.
Our research also delved into the mechanisms behind these effects. We found that rubiadin-induced hepcidin expression was mediated through a specific signaling pathway involving bone morphogenetic protein 6 (BMP6) and SMAD proteins. The ability of rubiadin to enhance hepcidin levels points toward a promising natural strategy for tackling iron overload in liver diseases and could have broader implications for treating related conditions.
Furthermore, when we administered rubiadin to mice with iron overload, it resulted in decreased serum and duodenal iron levels and an increase in hepcidin mRNA expression in the liver. This suggests that rubiadin may not only help the body regulate iron better but might also protect against the harmful effects of excess iron.
Our research also delved into the mechanisms behind these effects. We found that rubiadin-induced hepcidin expression was mediated through a specific signaling pathway involving bone morphogenetic protein 6 (BMP6) and SMAD proteins. The ability of rubiadin to enhance hepcidin levels points toward a promising natural strategy for tackling iron overload in liver diseases and could have broader implications for treating related conditions.
8.8
Restores iron levels
Most Useful Review
After using this iron supplement, my family’s blood tests showed that iron deficiency was resolved. I take it with vitamin C. It has also been beneficial for my family members suffering from moyamoya disease and has improved symptoms like vertigo in the elderly.
Constipation
SCIENTIFIC SCORE
Questionable
Based on 3 Researches
6
USERS' SCORE
Good
Based on 47 Reviews
8.2
7
Iron's minimal effect on constipation
Low-Dose Prophylactic Oral Iron Supplementation (Ferrous Fumarate, Ferrous Bisglycinate, and Ferrous Sulphate) in Pregnancy Is Not Associated With Clinically Significant Gastrointestinal Complaints: Results From Two Randomized Studies.
Most Relevant Research
We explored the effects of low-dose iron supplementation on gastrointestinal complaints, particularly constipation, in pregnant women. Conducting two randomized studies, we aimed to determine how different forms of iron—ferrous fumarate, ferrous bisglycinate, and ferrous sulphate—would affect the frequency of GI issues among healthy women throughout their pregnancy.
Through our investigations, we found that constipation was only significantly associated with higher doses of ferrous fumarate (80 mg/day). Interestingly, women taking lower doses of ferrous fumarate (20-60 mg/day) did not report more GI side effects, indicating that manageable doses of iron may be tolerated without significant worry about constipation.
Among the iron formulas tested, ferrous bisglycinate at 25 mg showed the best profile, resulting in fewer GI complaints overall compared to the others. In fact, it was linked to a lower incidence of black stools, which can often be associated with iron intake. Ultimately, we observed that while low-dose iron supplementation might incur some side effects, they are generally not severe enough to warrant a change in dosage or interruption of treatment.
Through our investigations, we found that constipation was only significantly associated with higher doses of ferrous fumarate (80 mg/day). Interestingly, women taking lower doses of ferrous fumarate (20-60 mg/day) did not report more GI side effects, indicating that manageable doses of iron may be tolerated without significant worry about constipation.
Among the iron formulas tested, ferrous bisglycinate at 25 mg showed the best profile, resulting in fewer GI complaints overall compared to the others. In fact, it was linked to a lower incidence of black stools, which can often be associated with iron intake. Ultimately, we observed that while low-dose iron supplementation might incur some side effects, they are generally not severe enough to warrant a change in dosage or interruption of treatment.
9.5
Quick results observed
Most Useful Review
Good quality and great price. I was exhausted and found out I’m anaemic, needing iron pills. After trying several brands with side effects, I was sceptical about this cheaper option but found none. No bloating or constipation with these, which work well for me.
Chest Pain
SCIENTIFIC SCORE
Likely Very Effective
Based on 3 Researches
9.2
USERS' SCORE
Moderately Good
Based on 1 Review
7.8
9
Endometrial cancer-induced angina case
An atypical presentation of endometrial cancer as angina secondary to critically low hemoglobin and iron deficiency associated pancytopenia: A case report.
Most Relevant Research
We explored the intriguing link between iron treatment and angina symptoms in a unique case involving a 46-year-old woman with endometrial cancer. This patient arrived in the emergency department with acute chest pain, yet her heart was healthy based on ECG results. Instead, we found that her chest pain was a result of critically low hemoglobin levels caused by severe iron deficiency anemia.
Over the past six months, the patient experienced prolonged and heavy menstruation, which contributed to her anemia. After administering six units of packed red blood cells and an iron infusion, we witnessed a remarkable turnaround. The chest pain resolved, and her blood counts improved significantly.
This case is particularly noteworthy for highlighting how essential it is for women experiencing chest pain to be evaluated for anemia. It serves as a crucial reminder that understanding a patient's gynecological history can shed light on their overall health and symptoms. The link between iron treatment and relief from chest pain underscores the importance of recognizing the systemic effects of anemia.
Over the past six months, the patient experienced prolonged and heavy menstruation, which contributed to her anemia. After administering six units of packed red blood cells and an iron infusion, we witnessed a remarkable turnaround. The chest pain resolved, and her blood counts improved significantly.
This case is particularly noteworthy for highlighting how essential it is for women experiencing chest pain to be evaluated for anemia. It serves as a crucial reminder that understanding a patient's gynecological history can shed light on their overall health and symptoms. The link between iron treatment and relief from chest pain underscores the importance of recognizing the systemic effects of anemia.
1.3
Warning advised
Most Useful Review
I gave my husband this complex for his low haemoglobin, taking half a tablet daily. However, after three days, I was hospitalised with severe stomach pain. The doctors struggled to diagnose the issue, despite normal test results. Although my haemoglobin returned to normal, the pain persisted until I stopped the medication on the third day.
Cancer
SCIENTIFIC SCORE
Likely Very Effective
Based on 10 Researches
9
USERS' SCORE
Moderately Good
Based on 1 Review
7.7
9
SPIO improves lymph node detection
Use of superparamagnetic iron oxide for sentinel lymph node detection following neoadjuvant systemic therapy. A systematic review and meta-analysis.
Most Relevant Research
We explored the effectiveness of superparamagnetic iron oxide (SPIO) in detecting sentinel lymph nodes in breast cancer patients who had undergone neoadjuvant systemic therapy before surgery. This study included a systematic review of multiple databases and focused on comparing SPIO to the standard methods involving radioisotope and blue dye.
Our findings highlight that SPIO successfully identified sentinel lymph nodes in about 98.1% of cases, while the standard method achieved a detection rate of 94.6%. When examining the number of lymph nodes retrieved, SPIO demonstrated superior performance, with an average of 2.26 nodes detected compared to 1.86 with the conventional approach.
The overall quality of the studies reviewed was considered good, indicating that we can reliably say SPIO can be safely and effectively adopted in clinical practice for these patients. This suggests a promising alternative in medical settings, where identifying lymph nodes accurately is crucial for treatment planning.
Our findings highlight that SPIO successfully identified sentinel lymph nodes in about 98.1% of cases, while the standard method achieved a detection rate of 94.6%. When examining the number of lymph nodes retrieved, SPIO demonstrated superior performance, with an average of 2.26 nodes detected compared to 1.86 with the conventional approach.
The overall quality of the studies reviewed was considered good, indicating that we can reliably say SPIO can be safely and effectively adopted in clinical practice for these patients. This suggests a promising alternative in medical settings, where identifying lymph nodes accurately is crucial for treatment planning.
0
Unnecessary additives
Most Useful Review
Contains unnecessary cancer-causing dyes. I wish I had checked the ingredients carefully; I assumed an iron supplement would just contain iron. These have multiple cancer-causing dyes, which are completely unnecessary. I ordered two bottles, and they are unreturnable. I won't introduce those dyes into my system, so my expenditure was a waste. These will go in the bin, and I'll be ordering another product instead.
Blood Clot
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6.5
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.4
9
ESA and iron enhance surgery outcomes
Use of preoperative erythropoietin-stimulating agents is associated with decreased thrombotic adverse events compared to red blood cell transfusion in surgical patients with anaemia.
Most Relevant Research
We aimed to understand how preoperative treatments like erythropoietin-stimulating agents (ESAs) and intravenous (IV) iron influence the risk of blood clots in surgical patients dealing with anaemia.
In our investigation, we found that patients who received ESAs—whether accompanied by IV iron or not—had lower risks of serious post-operative complications, including blood clots, compared to those who were given red blood cell transfusions. Specifically, those treated with ESAs without IV iron showed significant reductions in mortality and the occurrence of venous thromboembolic events.
Interestingly, when IV iron was combined with ESAs, it appeared to further enhance outcomes, notably improving survival rates. Our results suggest that combining these treatments might yield benefits for patients undergoing surgery, reflected in higher haemoglobin levels and fewer complications compared to traditional blood transfusions.
In our investigation, we found that patients who received ESAs—whether accompanied by IV iron or not—had lower risks of serious post-operative complications, including blood clots, compared to those who were given red blood cell transfusions. Specifically, those treated with ESAs without IV iron showed significant reductions in mortality and the occurrence of venous thromboembolic events.
Interestingly, when IV iron was combined with ESAs, it appeared to further enhance outcomes, notably improving survival rates. Our results suggest that combining these treatments might yield benefits for patients undergoing surgery, reflected in higher haemoglobin levels and fewer complications compared to traditional blood transfusions.
9.5
Normal haemoglobin levels
Most Useful Review
In 2012-2014, I suffered from acute leukaemia (blood cancer). I consistently had low haemoglobin and ferritin levels. I tried various iron supplements, but they caused side effects and stool issues. A friend recommended 21st Century iron, and I loved the capsule size and quality of ingredients. My haemoglobin levels are now consistently normal. I recommend it to everyone.
